locus-tag	class	description
WSWS_00001	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WSWS_00002	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WSWS_00003	COG1113	amino acid transport
WSWS_00006	COG1194	a g-specific adenine glycosylase
WSWS_00007	COG0357	Ribosomal RNA small subunit methyltransferase G
WSWS_00008	COG1192	Involved in chromosome partitioning
WSWS_00009	COG1475	DNA binding
WSWS_00010	COG4481	Protein conserved in bacteria
WSWS_00011	COG0012	GTP binding
WSWS_00013	COG0745	RESPONSE REGULATOR receiver
WSWS_00015	COG1686	Belongs to the peptidase S11 family
WSWS_00028	COG3091	SprT-like family
WSWS_00029	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
WSWS_00029	COG2755	lipolytic protein G-D-S-L family
WSWS_00030	COG0488	(ABC) transporter
WSWS_00032	COG3153	acetyltransferase
WSWS_00036	COG1418	mRNA catabolic process
WSWS_00037	COG2814	Major facilitator Superfamily
WSWS_00038	COG2188	Transcriptional regulator
WSWS_00039	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
WSWS_00040	COG0351	phosphomethylpyrimidine kinase
WSWS_00043	COG0708	Exodeoxyribonuclease III
WSWS_00044	COG1121	(ABC) transporter
WSWS_00045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WSWS_00047	COG0531	amino acid
WSWS_00049	COG1181	Belongs to the D-alanine--D-alanine ligase family
WSWS_00050	COG1435	thymidine kinase activity
WSWS_00052	COG2890	protein-(glutamine-N5) methyltransferase activity
WSWS_00053	COG0009	L-threonylcarbamoyladenylate synthase
WSWS_00054	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WSWS_00055	COG1511	domain protein
WSWS_00056	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WSWS_00057	COG2233	PERMEase
WSWS_00058	COG0356	it plays a direct role in the translocation of protons across the membrane
WSWS_00059	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WSWS_00060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WSWS_00062	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WSWS_00063	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WSWS_00064	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WSWS_00065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WSWS_00066	COG1428	Deoxynucleoside kinase
WSWS_00067	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WSWS_00071	COG0542	response to heat
WSWS_00072	COG0085	RNA polymerase activity
WSWS_00073	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WSWS_00077	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WSWS_00078	COG0242	peptide deformylase activity
WSWS_00080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WSWS_00082	COG0671	phosphoesterase, PA-phosphatase related
WSWS_00083	COG0495	leucyl-tRNA aminoacylation
WSWS_00085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WSWS_00086	COG3870	Protein conserved in bacteria
WSWS_00087	COG0470	DNA polymerase III
WSWS_00090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WSWS_00091	COG1214	PFAM Peptidase M22, glycoprotease
WSWS_00094	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WSWS_00096	COG0051	transcription antitermination factor activity, RNA binding
WSWS_00097	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WSWS_00099	COG0089	rRNA binding
WSWS_00100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WSWS_00101	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WSWS_00102	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WSWS_00103	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WSWS_00104	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WSWS_00105	COG0255	Belongs to the universal ribosomal protein uL29 family
WSWS_00107	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WSWS_00108	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WSWS_00109	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WSWS_00110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WSWS_00111	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WSWS_00112	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WSWS_00113	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WSWS_00114	COG1841	ribosomal large subunit assembly
WSWS_00115	COG0200	Binds to the 23S rRNA
WSWS_00118	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WSWS_00120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WSWS_00121	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WSWS_00122	COG0202	RNA polymerase activity
WSWS_00123	COG0203	ribosomal protein L17
WSWS_00127	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WSWS_00130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WSWS_00133	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
WSWS_00134	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WSWS_00135	COG0215	cysteine-tRNA ligase activity
WSWS_00136	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
WSWS_00137	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WSWS_00139	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WSWS_00141	COG0250	Participates in transcription elongation, termination and antitermination
WSWS_00142	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WSWS_00143	COG0081	regulation of translation
WSWS_00144	COG1956	GAF domain-containing protein
WSWS_00146	COG4989	oxidoreductase activity
WSWS_00148	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WSWS_00149	COG0222	ribosome binding
WSWS_00150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WSWS_00151	COG2723	6-phospho-beta-galactosidase activity
WSWS_00152	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WSWS_00153	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WSWS_00154	COG1447	Phosphotransferase system cellobiose-specific component IIA
WSWS_00155	COG2723	6-phospho-beta-galactosidase activity
WSWS_00158	COG2337	Toxic component of a toxin-antitoxin (TA) module
WSWS_00159	COG0477	Major facilitator Superfamily
WSWS_00160	COG1827	regulation of RNA biosynthetic process
WSWS_00161	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WSWS_00162	COG3973	AAA domain
WSWS_00163	COG0180	Tryptophanyl-tRNA synthetase
WSWS_00165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WSWS_00166	COG4166	transmembrane transport
WSWS_00167	COG2610	gluconate transmembrane transporter activity
WSWS_00168	COG1454	alcohol dehydrogenase
WSWS_00168	COG1012	belongs to the aldehyde dehydrogenase family
WSWS_00169	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WSWS_00171	COG1187	pseudouridine synthase activity
WSWS_00172	COG1733	regulation of RNA biosynthetic process
WSWS_00176	COG0861	Integral membrane protein TerC family
WSWS_00177	COG1252	NADH dehydrogenase
WSWS_00179	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WSWS_00180	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
WSWS_00181	COG1074	ATP-dependent DNA helicase activity
WSWS_00182	COG1064	alcohol dehydrogenase
WSWS_00183	COG2814	Major facilitator Superfamily
WSWS_00184	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WSWS_00186	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WSWS_00187	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WSWS_00188	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WSWS_00189	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WSWS_00191	COG0360	Binds together with S18 to 16S ribosomal RNA
WSWS_00192	COG0629	single-stranded DNA binding
WSWS_00193	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WSWS_00194	COG0346	lactoylglutathione lyase activity
WSWS_00197	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WSWS_00198	COG1122	ATPase activity
WSWS_00199	COG1122	ATPase activity
WSWS_00201	COG0101	tRNA pseudouridine synthase activity
WSWS_00202	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WSWS_00209	COG1196	nuclear chromosome segregation
WSWS_00209	COG1674	ftsk spoiiie
WSWS_00219	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
WSWS_00221	COG1088	dTDP-glucose 4,6-dehydratase activity
WSWS_00224	COG0561	phosphatase activity
WSWS_00227	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WSWS_00228	COG0248	Ppx GppA phosphatase
WSWS_00235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WSWS_00236	COG1957	nucleoside hydrolase
WSWS_00240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WSWS_00242	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WSWS_00242	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WSWS_00243	COG1268	BioY protein
WSWS_00244	COG0194	GDP metabolic process
WSWS_00248	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WSWS_00249	COG0765	amino acid transport
WSWS_00250	COG0765	amino acid transport
WSWS_00251	COG4166	transmembrane transport
WSWS_00252	COG0601	transmembrane transport
WSWS_00253	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WSWS_00254	COG0444	Belongs to the ABC transporter superfamily
WSWS_00255	COG4608	Belongs to the ABC transporter superfamily
WSWS_00256	COG0475	glutathione-regulated potassium exporter activity
WSWS_00259	COG0359	binds to the 23S rRNA
WSWS_00260	COG2176	DNA-directed DNA polymerase activity
WSWS_00266	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
WSWS_00270	COG2183	response to ionizing radiation
WSWS_00273	COG3842	ATPase activity
WSWS_00275	COG1177	transmembrane transport
WSWS_00276	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WSWS_00277	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WSWS_00278	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WSWS_00279	COG0459	protein refolding
WSWS_00280	COG1278	Cold shock
WSWS_00281	COG0628	permease
WSWS_00283	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WSWS_00284	COG1126	abc transporter atp-binding protein
WSWS_00285	COG3764	Sortase (surface protein transpeptidase)
WSWS_00287	COG0280	phosphate acetyltransferase
WSWS_00288	COG0305	Participates in initiation and elongation during chromosome replication
WSWS_00289	COG2814	Major facilitator Superfamily
WSWS_00294	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WSWS_00296	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WSWS_00298	COG0277	FAD linked oxidase domain protein
WSWS_00299	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WSWS_00300	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
WSWS_00301	COG3973	AAA domain
WSWS_00302	COG1072	(Pantothenic acid kinase))
WSWS_00303	COG0741	lytic transglycosylase activity
WSWS_00305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WSWS_00307	COG0589	response to stress
WSWS_00310	COG1272	protein, Hemolysin III
WSWS_00311	COG4862	establishment of competence for transformation
WSWS_00313	COG4120	Belongs to the binding-protein-dependent transport system permease family
WSWS_00314	COG1122	ATPase activity
WSWS_00318	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WSWS_00319	COG4472	Bacterial protein of unknown function (DUF965)
WSWS_00321	COG2246	polysaccharide biosynthetic process
WSWS_00322	COG3906	Belongs to the UPF0473 family
WSWS_00323	COG3906	Belongs to the UPF0473 family
WSWS_00324	COG1597	lipid kinase activity
WSWS_00326	COG2252	PERMEase
WSWS_00330	COG0561	phosphatase activity
WSWS_00331	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WSWS_00332	COG4589	Belongs to the CDS family
WSWS_00333	COG0750	zinc metalloprotease
WSWS_00335	COG2244	polysaccharide biosynthetic process
WSWS_00337	COG0442	prolyl-tRNA aminoacylation
WSWS_00338	COG0571	ribonuclease III activity
WSWS_00339	COG1196	nuclear chromosome segregation
WSWS_00340	COG0552	protein localization to endoplasmic reticulum
WSWS_00342	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WSWS_00344	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WSWS_00346	COG4684	Psort location CytoplasmicMembrane, score
WSWS_00347	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
WSWS_00348	COG0351	phosphomethylpyrimidine kinase
WSWS_00349	COG0352	thiamine-phosphate diphosphorylase activity
WSWS_00351	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WSWS_00352	COG0716	FMN binding
WSWS_00353	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WSWS_00355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WSWS_00356	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WSWS_00357	COG1846	Transcriptional regulator
WSWS_00359	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WSWS_00361	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WSWS_00362	COG1028	Short-chain dehydrogenase reductase Sdr
WSWS_00363	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WSWS_00366	COG0439	Biotin carboxylase
WSWS_00367	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WSWS_00368	COG0825	malonyl-CoA metabolic process
WSWS_00377	COG4485	Bacterial membrane protein, YfhO
WSWS_00379	COG3715	PTS system
WSWS_00380	COG3716	PTS system mannose fructose sorbose family IID component
WSWS_00382	COG2137	regulation of response to DNA damage stimulus
WSWS_00385	COG1132	(ABC) transporter
WSWS_00386	COG1132	(ABC) transporter
WSWS_00389	COG0006	proline dipeptidase activity
WSWS_00390	COG1609	Transcriptional regulator
WSWS_00391	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WSWS_00392	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WSWS_00393	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WSWS_00394	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WSWS_00395	COG0047	phosphoribosylformylglycinamidine synthase activity
WSWS_00396	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WSWS_00398	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WSWS_00399	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WSWS_00400	COG0138	bifunctional purine biosynthesis protein purh
WSWS_00402	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WSWS_00403	COG4166	transmembrane transport
WSWS_00404	COG1228	amidohydrolase
WSWS_00406	COG2807	transmembrane transport
WSWS_00408	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WSWS_00412	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WSWS_00416	COG1381	Involved in DNA repair and RecF pathway recombination
WSWS_00417	COG0752	glycyl-tRNA synthetase alpha subunit
WSWS_00418	COG0751	glycine-tRNA ligase activity
WSWS_00421	COG0632	four-way junction helicase activity
WSWS_00422	COG2255	four-way junction helicase activity
WSWS_00423	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WSWS_00425	COG1862	Preprotein translocase
WSWS_00427	COG1307	EDD domain protein, DegV family
WSWS_00428	COG0446	pyridine nucleotide-disulphide oxidoreductase
WSWS_00431	COG0789	Transcriptional regulator
WSWS_00441	COG1940	carbohydrate kinase activity
WSWS_00442	COG0765	amino acid transport
WSWS_00443	COG1126	abc transporter atp-binding protein
WSWS_00445	COG0083	homoserine kinase activity
WSWS_00447	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WSWS_00450	COG1388	LysM domain
WSWS_00450	COG1705	Flagellar rod assembly protein muramidase FlgJ
WSWS_00454	COG0564	pseudouridine synthase activity
WSWS_00458	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WSWS_00464	COG0833	amino acid
WSWS_00466	COG2723	6-phospho-beta-galactosidase activity
WSWS_00467	COG3711	transcriptional antiterminator
WSWS_00469	COG2264	protein methyltransferase activity
WSWS_00470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WSWS_00472	COG2001	Belongs to the MraZ family
WSWS_00473	COG0275	rRNA processing
WSWS_00476	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WSWS_00477	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WSWS_00478	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WSWS_00481	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WSWS_00482	COG1799	cell septum assembly
WSWS_00485	COG3599	regulation of cell shape
WSWS_00486	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WSWS_00491	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WSWS_00492	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WSWS_00493	COG0513	Belongs to the DEAD box helicase family
WSWS_00494	COG0024	Methionine aminopeptidase
WSWS_00497	COG1164	Oligoendopeptidase f
WSWS_00498	COG0779	Required for maturation of 30S ribosomal subunits
WSWS_00499	COG0195	Participates in both transcription termination and antitermination
WSWS_00500	COG2740	Nucleic-acid-binding protein implicated in transcription termination
WSWS_00502	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WSWS_00503	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WSWS_00504	COG2996	Protein conserved in bacteria
WSWS_00507	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WSWS_00508	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WSWS_00509	COG1187	pseudouridine synthase activity
WSWS_00510	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
WSWS_00512	COG0514	ATP-dependent DNA helicase (RecQ)
WSWS_00514	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WSWS_00515	COG0539	negative regulation of cytoplasmic translation
WSWS_00516	COG1160	GTP binding
WSWS_00517	COG0776	regulation of translation
WSWS_00520	COG0242	peptide deformylase activity
WSWS_00522	COG0483	inositol monophosphate 1-phosphatase activity
WSWS_00524	COG0772	Belongs to the SEDS family
WSWS_00525	COG4471	UPF0298 protein
WSWS_00526	COG0742	ribosomal rna small subunit methyltransferase
WSWS_00527	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WSWS_00528	COG3480	Lon protease (S16) C-terminal proteolytic domain
WSWS_00533	COG1193	negative regulation of DNA recombination
WSWS_00536	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WSWS_00537	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WSWS_00541	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WSWS_00543	COG0018	arginyl-trna synthetase
WSWS_00544	COG2188	Transcriptional regulator
WSWS_00545	COG2190	(PTS) system
WSWS_00545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WSWS_00545	COG1263	PTS System
WSWS_00546	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WSWS_00546	COG2190	(PTS) system
WSWS_00546	COG1263	PTS System
WSWS_00547	COG0366	Alpha amylase catalytic
WSWS_00550	COG2169	Transcriptional regulator
WSWS_00550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WSWS_00552	COG1230	cation diffusion facilitator family transporter
WSWS_00553	COG2814	Major facilitator Superfamily
WSWS_00559	COG4619	ABC transporter
WSWS_00560	COG0390	transport system, permease component
WSWS_00563	COG0463	Glycosyl transferase, family 2
WSWS_00564	COG1215	transferase activity, transferring glycosyl groups
WSWS_00565	COG1134	teichoic acid transport
WSWS_00565	COG1388	LysM domain
WSWS_00566	COG1682	transport, permease protein
WSWS_00569	COG0351	phosphomethylpyrimidine kinase
WSWS_00571	COG2814	Major facilitator Superfamily
WSWS_00574	COG4474	Belongs to the UPF0398 family
WSWS_00575	COG3599	regulation of cell shape
WSWS_00576	COG0670	Belongs to the BI1 family
WSWS_00577	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WSWS_00577	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WSWS_00578	COG1234	tRNA 3'-trailer cleavage
WSWS_00579	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WSWS_00579	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
WSWS_00581	COG0124	histidyl-tRNA synthetase
WSWS_00582	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WSWS_00583	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WSWS_00585	COG0588	phosphoglycerate mutase activity
WSWS_00587	COG0105	UTP biosynthetic process
WSWS_00589	COG1979	alcohol dehydrogenase
WSWS_00590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WSWS_00591	COG4166	transmembrane transport
WSWS_00592	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WSWS_00594	COG1304	FMN binding
WSWS_00598	COG1199	ATP-dependent helicase activity
WSWS_00598	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WSWS_00600	COG0017	Asparaginyl-tRNA synthetase
WSWS_00603	COG0617	tRNA 3'-terminal CCA addition
WSWS_00604	COG0488	(ABC) transporter
WSWS_00607	COG0587	DNA-directed DNA polymerase activity
WSWS_00609	COG2936	dipeptidyl-peptidase activity
WSWS_00611	COG0745	RESPONSE REGULATOR receiver
WSWS_00612	COG5002	protein histidine kinase activity
WSWS_00613	COG0572	uridine kinase
WSWS_00614	COG1363	Peptidase, m42
WSWS_00615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WSWS_00619	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WSWS_00620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WSWS_00621	COG0237	dephospho-CoA kinase activity
WSWS_00623	COG1484	DNA-dependent DNA replication
WSWS_00626	COG0745	RESPONSE REGULATOR receiver
WSWS_00627	COG5002	protein histidine kinase activity
WSWS_00628	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WSWS_00632	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WSWS_00633	COG1610	YqeY-like protein
WSWS_00634	COG1702	phosphate starvation-inducible protein PhoH
WSWS_00635	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WSWS_00636	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WSWS_00637	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WSWS_00638	COG0196	riboflavin kinase activity
WSWS_00644	COG1307	EDD domain protein, DegV family
WSWS_00645	COG1307	EDD domain protein, DegV family
WSWS_00646	COG2755	lipolytic protein G-D-S-L family
WSWS_00648	COG4479	Belongs to the UPF0346 family
WSWS_00663	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WSWS_00664	COG0758	DNA mediated transformation
WSWS_00665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WSWS_00666	COG4974	Belongs to the 'phage' integrase family
WSWS_00669	COG0187	DNA topoisomerase II activity
WSWS_00670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WSWS_00671	COG0481	GTPase activity
WSWS_00672	COG0116	Belongs to the methyltransferase superfamily
WSWS_00674	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WSWS_00676	COG1279	arginine transmembrane transporter activity
WSWS_00678	COG0556	nucleotide-excision repair
WSWS_00680	COG0537	adenosine 5'-monophosphoramidase activity
WSWS_00681	COG1131	(ABC) transporter
WSWS_00683	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WSWS_00686	COG0438	transferase activity, transferring glycosyl groups
WSWS_00688	COG2223	nitrite transmembrane transporter activity
WSWS_00689	COG0095	Lipoate-protein ligase
WSWS_00696	COG0346	lactoylglutathione lyase activity
WSWS_00698	COG1316	TRANSCRIPTIONal
WSWS_00701	COG1028	Short-chain dehydrogenase reductase Sdr
WSWS_00709	COG1136	(ABC) transporter
WSWS_00710	COG0577	efflux transmembrane transporter activity
WSWS_00711	COG2197	response regulator
WSWS_00712	COG4585	Histidine kinase
WSWS_00713	COG2409	Drug exporters of the RND superfamily
WSWS_00714	COG0789	Transcriptional regulator
WSWS_00717	COG0656	L-ascorbic acid biosynthetic process
WSWS_00722	COG0431	NADPH-dependent FMN reductase
WSWS_00724	COG4221	oxidoreductase activity
WSWS_00726	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WSWS_00727	COG0789	Transcriptional regulator
WSWS_00730	COG1942	4-Oxalocrotonate Tautomerase
WSWS_00731	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WSWS_00731	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WSWS_00731	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WSWS_00732	COG1105	Belongs to the carbohydrate kinase PfkB family
WSWS_00733	COG1349	DNA-binding transcription factor activity
WSWS_00736	COG1131	(ABC) transporter
WSWS_00738	COG0318	PFAM AMP-dependent synthetase and ligase
WSWS_00739	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WSWS_00741	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WSWS_00742	COG0318	PFAM AMP-dependent synthetase and ligase
WSWS_00743	COG0494	nUDIX hydrolase
WSWS_00745	COG1490	D-aminoacyl-tRNA deacylase activity
WSWS_00746	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WSWS_00747	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WSWS_00748	COG0358	DNA primase activity
WSWS_00750	COG2070	2-Nitropropane dioxygenase
WSWS_00752	COG0583	DNA-binding transcription factor activity
WSWS_00753	COG2274	protein secretion by the type I secretion system
WSWS_00754	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WSWS_00755	COG2723	6-phospho-beta-galactosidase activity
WSWS_00756	COG2188	Transcriptional regulator
WSWS_00759	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
WSWS_00760	COG1733	regulation of RNA biosynthetic process
WSWS_00764	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WSWS_00765	COG0481	GTPase activity
WSWS_00766	COG0481	GTPase activity
WSWS_00769	COG2211	Major facilitator Superfamily
WSWS_00773	COG2966	Psort location CytoplasmicMembrane, score
WSWS_00774	COG1473	amidohydrolase
WSWS_00775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WSWS_00779	COG1609	Transcriptional regulator
WSWS_00780	COG0531	amino acid
WSWS_00784	COG4175	Glycine betaine
WSWS_00784	COG3448	diguanylate cyclase activity
WSWS_00786	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WSWS_00787	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WSWS_00789	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
WSWS_00793	COG4946	Tricorn protease homolog
WSWS_00793	COG1506	peptidase
WSWS_00793	COG0823	Involved in the tonB-independent uptake of proteins
WSWS_00794	COG0268	Binds directly to 16S ribosomal RNA
WSWS_00795	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WSWS_00796	COG1466	dna polymerase III delta subunit
WSWS_00798	COG1555	photosystem II stabilization
WSWS_00798	COG1596	polysaccharide export
WSWS_00804	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
WSWS_00805	COG3266	domain, Protein
WSWS_00805	COG5632	N-Acetylmuramoyl-L-alanine amidase
WSWS_00805	COG4193	domain, Protein
WSWS_00806	COG3942	CHAP domain
WSWS_00806	COG1705	Flagellar rod assembly protein muramidase FlgJ
WSWS_00809	COG2814	Major facilitator Superfamily
WSWS_00810	COG0477	Major facilitator Superfamily
WSWS_00811	COG3883	PFAM NLP P60 protein
WSWS_00811	COG0791	NLP P60 protein
WSWS_00812	COG3048	D-serine ammonia-lyase activity
WSWS_00813	COG1739	Uncharacterized protein family UPF0029
WSWS_00820	COG4224	UPF0291 protein
WSWS_00821	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WSWS_00824	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WSWS_00825	COG2384	SAM-dependent methyltransferase
WSWS_00826	COG1597	lipid kinase activity
WSWS_00828	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WSWS_00829	COG0601	transmembrane transport
WSWS_00830	COG4608	Belongs to the ABC transporter superfamily
WSWS_00831	COG0444	Belongs to the ABC transporter superfamily
WSWS_00832	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WSWS_00835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WSWS_00836	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WSWS_00839	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WSWS_00841	COG0052	Belongs to the universal ribosomal protein uS2 family
WSWS_00842	COG2827	Endonuclease containing a URI domain
WSWS_00843	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WSWS_00844	COG0204	Acyl-transferase
WSWS_00845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WSWS_00846	COG0322	excinuclease ABC activity
WSWS_00848	COG1126	abc transporter atp-binding protein
WSWS_00851	COG1674	ftsk spoiiie
WSWS_00853	COG0628	permease
WSWS_00854	COG2706	6-phosphogluconolactonase activity
WSWS_00856	COG0436	Aminotransferase
WSWS_00857	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WSWS_00858	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WSWS_00859	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WSWS_00860	COG1473	amidohydrolase
WSWS_00861	COG2171	N-acyltransferase activity
WSWS_00863	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WSWS_00864	COG0527	aspartate kinase activity
WSWS_00867	COG0393	Putative heavy-metal-binding
WSWS_00873	COG0561	phosphatase activity
WSWS_00875	COG1428	Deoxynucleoside kinase
WSWS_00877	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WSWS_00878	COG1942	4-Oxalocrotonate Tautomerase
WSWS_00879	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WSWS_00880	COG0335	large ribosomal subunit rRNA binding
WSWS_00882	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WSWS_00883	COG1546	Belongs to the CinA family
WSWS_00883	COG1058	Belongs to the CinA family
WSWS_00886	COG2814	Major facilitator Superfamily
WSWS_00887	COG0564	pseudouridine synthase activity
WSWS_00888	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WSWS_00889	COG2357	RelA SpoT domain protein
WSWS_00890	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
WSWS_00891	COG0562	UDP-galactopyranose mutase
WSWS_00892	COG1216	Glycosyl transferase, family 2
WSWS_00893	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WSWS_00894	COG0154	amidase activity
WSWS_00895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WSWS_00896	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WSWS_00896	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
WSWS_00897	COG0561	phosphatase activity
WSWS_00899	COG0667	Aldo Keto reductase
WSWS_00900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WSWS_00901	COG0167	dihydroorotate dehydrogenase activity
WSWS_00903	COG1122	ATPase activity
WSWS_00907	COG0706	membrane insertase activity
WSWS_00909	COG1335	isochorismatase
WSWS_00910	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
WSWS_00912	COG0400	carboxylic ester hydrolase activity
WSWS_00913	COG0346	lactoylglutathione lyase activity
WSWS_00917	COG2261	transglycosylase associated protein
WSWS_00919	COG5001	Diguanylate cyclase
WSWS_00920	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WSWS_00927	COG3953	SLT domain
WSWS_00927	COG5280	Phage tail tape measure protein TP901
WSWS_00941	COG1573	uracil-dna glycosylase
WSWS_00944	COG0110	maltose O-acetyltransferase activity
WSWS_00951	COG3723	Recombinational DNA repair protein, rece pathway
WSWS_00962	COG1396	sequence-specific DNA binding
WSWS_00972	COG5001	Diguanylate cyclase
WSWS_00974	COG2514	catechol 2,3-dioxygenase activity
WSWS_00979	COG2199	diguanylate cyclase activity
WSWS_00980	COG5002	protein histidine kinase activity
WSWS_00982	COG1017	nitric oxide dioxygenase activity
WSWS_00982	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WSWS_00984	COG1131	(ABC) transporter
WSWS_00986	COG0741	lytic transglycosylase activity
WSWS_00987	COG0741	lytic transglycosylase activity
WSWS_00989	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WSWS_00991	COG1668	transmembrane transport
WSWS_00992	COG4152	abc transporter atp-binding protein
WSWS_00993	COG0525	valine-tRNA ligase activity
WSWS_00994	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WSWS_00998	COG1607	acyl-coa hydrolase
WSWS_01000	COG0330	HflC and HflK could
WSWS_01005	COG2261	transglycosylase associated protein
WSWS_01006	COG0228	four-way junction DNA binding
WSWS_01007	COG0584	glycerophosphoryl diester phosphodiesterase
WSWS_01008	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WSWS_01009	COG0531	amino acid
WSWS_01010	COG1792	Involved in formation and maintenance of cell shape
WSWS_01011	COG1077	Cell shape determining protein MreB Mrl
WSWS_01012	COG2003	Belongs to the UPF0758 family
WSWS_01015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WSWS_01017	COG0494	nUDIX hydrolase
WSWS_01018	COG1278	Cold shock
WSWS_01021	COG1744	ABC transporter substrate-binding protein PnrA-like
WSWS_01022	COG1132	(ABC) transporter
WSWS_01023	COG1132	(ABC) transporter
WSWS_01024	COG1846	Transcriptional regulator
WSWS_01025	COG4720	Psort location CytoplasmicMembrane, score
WSWS_01026	COG0564	pseudouridine synthase activity
WSWS_01027	COG0604	alcohol dehydrogenase
WSWS_01028	COG0436	Aminotransferase
WSWS_01030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WSWS_01034	COG1121	(ABC) transporter
WSWS_01036	COG1846	Transcriptional regulator
WSWS_01039	COG1940	carbohydrate kinase activity
WSWS_01040	COG2190	(PTS) system
WSWS_01040	COG2211	Major facilitator Superfamily
WSWS_01042	COG1464	Belongs to the NlpA lipoprotein family
WSWS_01048	COG0656	L-ascorbic acid biosynthetic process
WSWS_01051	COG2160	L-arabinose isomerase activity
WSWS_01054	COG1609	Transcriptional regulator
WSWS_01055	COG1940	carbohydrate kinase activity
WSWS_01056	COG1621	beta-fructofuranosidase activity
WSWS_01058	COG1609	Transcriptional regulator
WSWS_01060	COG0697	spore germination
WSWS_01062	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WSWS_01063	COG0004	ammonium transporteR
WSWS_01064	COG0860	N-Acetylmuramoyl-L-alanine amidase
WSWS_01066	COG0306	phosphate transporter
WSWS_01067	COG0028	Belongs to the TPP enzyme family
WSWS_01069	COG1914	H( )-stimulated, divalent metal cation uptake system
WSWS_01070	COG3477	response to acidic pH
WSWS_01074	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WSWS_01075	COG0719	Fe-S assembly protein
WSWS_01077	COG0602	queuosine metabolic process
WSWS_01079	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WSWS_01081	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
WSWS_01082	COG3425	synthase
WSWS_01083	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WSWS_01086	COG0626	cystathionine gamma-synthase activity
WSWS_01089	COG0443	Heat shock 70 kDa protein
WSWS_01090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WSWS_01091	COG1420	regulation of RNA biosynthetic process
WSWS_01095	COG1309	transcriptional regulator
WSWS_01097	COG0419	ATPase involved in DNA repair
WSWS_01100	COG1970	mechanosensitive ion channel activity
WSWS_01101	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WSWS_01102	COG1426	Protein conserved in bacteria
WSWS_01103	COG0612	Peptidase, M16
WSWS_01104	COG0612	Peptidase, M16
WSWS_01105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WSWS_01106	COG1368	sulfuric ester hydrolase activity
WSWS_01109	COG0438	transferase activity, transferring glycosyl groups
WSWS_01110	COG0438	transferase activity, transferring glycosyl groups
WSWS_01111	COG0363	glucosamine-6-phosphate deaminase activity
WSWS_01112	COG1070	Carbohydrate kinase
WSWS_01113	COG3481	metal-dependent phosphohydrolase, HD sub domain
WSWS_01114	COG1322	Protein conserved in bacteria
WSWS_01115	COG3679	Belongs to the UPF0342 family
WSWS_01116	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WSWS_01117	COG1438	arginine binding
WSWS_01119	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WSWS_01120	COG3853	Toxic anion resistance protein (TelA)
WSWS_01124	COG1113	amino acid transport
WSWS_01126	COG0254	rRNA binding
WSWS_01128	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WSWS_01129	COG0284	orotidine-5'-phosphate decarboxylase activity
WSWS_01130	COG0167	dihydroorotate dehydrogenase activity
WSWS_01131	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WSWS_01132	COG0505	Belongs to the CarA family
WSWS_01134	COG0540	Belongs to the ATCase OTCase family
WSWS_01136	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WSWS_01137	COG4856	YbbR-like protein
WSWS_01140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WSWS_01143	COG0802	atpase or kinase
WSWS_01144	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WSWS_01145	COG0416	fatty acid biosynthetic process
WSWS_01146	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WSWS_01147	COG1461	Dihydroxyacetone kinase
WSWS_01149	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WSWS_01151	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WSWS_01152	COG1162	GTPase activity
WSWS_01153	COG0515	serine threonine protein kinase
WSWS_01153	COG2815	serine threonine protein kinase
WSWS_01154	COG0631	protein serine/threonine phosphatase activity
WSWS_01155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WSWS_01155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WSWS_01156	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WSWS_01157	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WSWS_01158	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WSWS_01164	COG4537	Required for transformation and DNA binding
WSWS_01166	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WSWS_01167	COG2252	PERMEase
WSWS_01168	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WSWS_01170	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WSWS_01171	COG4988	ABC transporter
WSWS_01172	COG1294	oxidase, subunit
WSWS_01173	COG1271	oxidase subunit
WSWS_01195	COG1098	S1 RNA binding domain
WSWS_01197	COG0586	Pfam SNARE associated Golgi protein
WSWS_01199	COG1758	RNA polymerase activity
WSWS_01200	COG0194	GDP metabolic process
WSWS_01202	COG0497	DNA recombination
WSWS_01203	COG1438	arginine binding
WSWS_01204	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
WSWS_01205	COG0142	geranyltranstransferase activity
WSWS_01207	COG1570	exodeoxyribonuclease VII activity
WSWS_01208	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WSWS_01210	COG1122	ATPase activity
WSWS_01211	COG4720	Psort location CytoplasmicMembrane, score
WSWS_01214	COG0488	(ABC) transporter
WSWS_01215	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
WSWS_01216	COG0513	Belongs to the DEAD box helicase family
WSWS_01217	COG0673	inositol 2-dehydrogenase activity
WSWS_01219	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WSWS_01221	COG1323	Belongs to the UPF0348 family
WSWS_01222	COG2226	methyltransferase
WSWS_01223	COG0799	negative regulation of ribosome biogenesis
WSWS_01224	COG1713	HD superfamily hydrolase involved in NAD metabolism
WSWS_01225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WSWS_01227	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WSWS_01230	COG0126	phosphoglycerate kinase activity
WSWS_01232	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WSWS_01240	COG0149	triose-phosphate isomerase activity
WSWS_01241	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WSWS_01242	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WSWS_01244	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WSWS_01245	COG0492	ferredoxin-NADP+ reductase activity
WSWS_01246	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WSWS_01247	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WSWS_01248	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
WSWS_01249	COG1950	PFAM Membrane protein of
WSWS_01250	COG0589	response to stress
WSWS_01252	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WSWS_01253	COG0049	tRNA binding
WSWS_01254	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WSWS_01256	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WSWS_01257	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WSWS_01258	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WSWS_01260	COG1302	Protein conserved in bacteria
WSWS_01261	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WSWS_01262	COG0166	Belongs to the GPI family
WSWS_01263	COG2017	converts alpha-aldose to the beta-anomer
WSWS_01264	COG4975	Glucose uptake
WSWS_01265	COG5002	protein histidine kinase activity
WSWS_01265	COG3850	Histidine kinase
WSWS_01266	COG0745	RESPONSE REGULATOR receiver
WSWS_01267	COG0765	amino acid transport
WSWS_01268	COG0402	S-adenosylhomocysteine deaminase activity
WSWS_01271	COG2217	Heavy metal translocating P-type atpase
WSWS_01274	COG2217	Heavy metal translocating P-type atpase
WSWS_01276	COG0604	alcohol dehydrogenase
WSWS_01280	COG0557	exoribonuclease II activity
WSWS_01282	COG0647	UMP catabolic process
WSWS_01284	COG0737	Belongs to the 5'-nucleotidase family
WSWS_01287	COG0006	proline dipeptidase activity
WSWS_01289	COG0596	Alpha beta hydrolase
WSWS_01290	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WSWS_01291	COG1169	isochorismate synthase
WSWS_01295	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WSWS_01305	COG0789	Transcriptional regulator
WSWS_01306	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WSWS_01310	COG1940	carbohydrate kinase activity
WSWS_01313	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WSWS_01315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WSWS_01317	COG0704	Plays a role in the regulation of phosphate uptake
WSWS_01318	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WSWS_01320	COG0581	inorganic phosphate transmembrane transporter activity
WSWS_01321	COG0573	inorganic phosphate transmembrane transporter activity
WSWS_01322	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WSWS_01325	COG0577	efflux transmembrane transporter activity
WSWS_01325	COG1136	(ABC) transporter
WSWS_01328	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WSWS_01329	COG0772	Belongs to the SEDS family
WSWS_01331	COG1077	Cell shape determining protein MreB Mrl
WSWS_01332	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WSWS_01333	COG1136	(ABC) transporter
WSWS_01334	COG0577	efflux transmembrane transporter activity
WSWS_01338	COG0588	phosphoglycerate mutase activity
WSWS_01339	COG0492	ferredoxin-NADP+ reductase activity
WSWS_01340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WSWS_01341	COG0072	phenylalanine-tRNA ligase activity
WSWS_01341	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WSWS_01342	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WSWS_01343	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WSWS_01344	COG4956	integral membrane protein (PIN domain superfamily)
WSWS_01346	COG0756	dUTP diphosphatase activity
WSWS_01349	COG3942	CHAP domain
WSWS_01349	COG1388	LysM domain
WSWS_01350	COG0542	response to heat
WSWS_01356	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WSWS_01357	COG0740	serine-type endopeptidase activity
WSWS_01358	COG1481	regulation of sporulation
WSWS_01360	COG1660	Displays ATPase and GTPase activities
WSWS_01361	COG3507	Belongs to the glycosyl hydrolase 43 family
WSWS_01364	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WSWS_01365	COG0653	protein targeting
WSWS_01366	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WSWS_01367	COG3442	glutamine amidotransferase
WSWS_01368	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WSWS_01369	COG1482	cell wall glycoprotein biosynthetic process
WSWS_01374	COG1132	(ABC) transporter
WSWS_01375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WSWS_01378	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WSWS_01380	COG0561	phosphatase activity
WSWS_01381	COG1078	dGTPase activity
WSWS_01383	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WSWS_01384	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
WSWS_01387	COG5002	protein histidine kinase activity
WSWS_01388	COG0745	RESPONSE REGULATOR receiver
WSWS_01390	COG3590	peptidase
WSWS_01396	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WSWS_01397	COG3104	oligopeptide transport
WSWS_01399	COG2813	Specifically methylates the guanine in position
WSWS_01404	COG0500	methyltransferase
WSWS_01406	COG1121	(ABC) transporter
WSWS_01411	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WSWS_01412	COG0336	Belongs to the RNA methyltransferase TrmD family
WSWS_01414	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WSWS_01417	COG1959	2 iron, 2 sulfur cluster binding
WSWS_01418	COG0702	epimerase
WSWS_01431	COG0438	transferase activity, transferring glycosyl groups
WSWS_01432	COG0438	transferase activity, transferring glycosyl groups
WSWS_01433	COG2084	Dehydrogenase
WSWS_01434	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WSWS_01435	COG2233	PERMEase
WSWS_01436	COG1744	ABC transporter substrate-binding protein PnrA-like
WSWS_01437	COG2252	PERMEase
WSWS_01438	COG0504	CTP synthase activity
WSWS_01439	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WSWS_01441	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WSWS_01442	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
WSWS_01443	COG1737	Transcriptional regulator
WSWS_01446	COG0626	cystathionine gamma-synthase activity
WSWS_01447	COG1464	Belongs to the NlpA lipoprotein family
WSWS_01448	COG1854	S-ribosylhomocysteine lyase activity
WSWS_01449	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WSWS_01451	COG1473	amidohydrolase
WSWS_01452	COG3118	belongs to the thioredoxin family
WSWS_01461	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WSWS_01462	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WSWS_01463	COG3527	Alpha-acetolactate decarboxylase
WSWS_01464	COG0028	Belongs to the TPP enzyme family
WSWS_01469	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
WSWS_01470	COG2244	polysaccharide biosynthetic process
WSWS_01471	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WSWS_01472	COG0193	aminoacyl-tRNA hydrolase activity
WSWS_01476	COG2115	Belongs to the xylose isomerase family
WSWS_01477	COG0640	Transcriptional regulator
WSWS_01482	COG2211	Major facilitator Superfamily
WSWS_01485	COG1968	undecaprenyl-diphosphatase activity
WSWS_01490	COG0395	ABC-type sugar transport system, permease component
WSWS_01492	COG3842	ATPase activity
WSWS_01493	COG0737	Belongs to the 5'-nucleotidase family
WSWS_01494	COG1316	TRANSCRIPTIONal
WSWS_01495	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WSWS_01496	COG2131	deaminase
WSWS_01498	COG1253	flavin adenine dinucleotide binding
WSWS_01499	COG1253	flavin adenine dinucleotide binding
WSWS_01500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WSWS_01502	COG0084	hydrolase, TatD family'
WSWS_01503	COG2855	membrane
WSWS_01504	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WSWS_01507	COG1113	amino acid transport
WSWS_01508	COG1181	Belongs to the D-alanine--D-alanine ligase family
WSWS_01508	COG2918	glutathione biosynthetic process
WSWS_01512	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
WSWS_01513	COG1609	Transcriptional regulator
WSWS_01514	COG2211	Major facilitator Superfamily
WSWS_01514	COG2190	(PTS) system
WSWS_01515	COG3250	beta-galactosidase activity
WSWS_01516	COG0436	Aminotransferase
WSWS_01518	COG3475	LICD family
WSWS_01519	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WSWS_01521	COG0110	maltose O-acetyltransferase activity
WSWS_01523	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
WSWS_01523	COG0463	Glycosyl transferase, family 2
WSWS_01527	COG1682	transport, permease protein
WSWS_01528	COG1134	teichoic acid transport
WSWS_01531	COG0463	Glycosyl transferase, family 2
WSWS_01531	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
WSWS_01532	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
WSWS_01532	COG0463	Glycosyl transferase, family 2
WSWS_01533	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WSWS_01543	COG1368	sulfuric ester hydrolase activity
WSWS_01547	COG0187	DNA topoisomerase II activity
WSWS_01548	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WSWS_01549	COG2501	S4 domain
WSWS_01550	COG0586	Pfam SNARE associated Golgi protein
WSWS_01552	COG0592	DNA-directed DNA polymerase activity
WSWS_01553	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WSWS_01554	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WSWS_01555	COG0594	ribonuclease P activity
WSWS_01556	COG0706	membrane insertase activity
WSWS_01562	COG2801	Transposase and inactivated derivatives
WSWS_01570	COG1254	Belongs to the acylphosphatase family
WSWS_01571	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WSWS_01572	COG0765	amino acid transport
WSWS_01573	COG1126	abc transporter atp-binding protein
WSWS_01574	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WSWS_01574	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WSWS_01575	COG0681	Belongs to the peptidase S26 family
WSWS_01576	COG0569	domain protein
WSWS_01577	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WSWS_01578	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WSWS_01579	COG0561	phosphatase activity
WSWS_01581	COG0436	Aminotransferase
WSWS_01582	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WSWS_01586	COG0328	RNA-DNA hybrid ribonuclease activity
WSWS_01587	COG1846	Transcriptional regulator
WSWS_01593	COG1511	domain protein
WSWS_01595	COG0277	FAD linked oxidase domain protein
WSWS_01596	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
WSWS_01598	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WSWS_01599	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
WSWS_01601	COG0519	Catalyzes the synthesis of GMP from XMP
WSWS_01601	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WSWS_01602	COG2211	Major facilitator Superfamily
WSWS_01603	COG3940	Belongs to the glycosyl hydrolase 43 family
WSWS_01606	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WSWS_01607	COG4166	transmembrane transport
WSWS_01608	COG0656	L-ascorbic acid biosynthetic process
WSWS_01609	COG1309	transcriptional regulator
WSWS_01611	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WSWS_01612	COG0531	amino acid
WSWS_01615	COG0628	permease
WSWS_01616	COG2309	aminopeptidase activity
WSWS_01618	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WSWS_01619	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WSWS_01621	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WSWS_01622	COG0531	amino acid
WSWS_01623	COG0252	asparaginase activity
WSWS_01624	COG4443	Transcriptional Coactivator p15 (PC4)
WSWS_01625	COG2226	methyltransferase
WSWS_01626	COG2050	protein possibly involved in aromatic compounds catabolism
WSWS_01627	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WSWS_01629	COG0745	RESPONSE REGULATOR receiver
WSWS_01630	COG5002	protein histidine kinase activity
WSWS_01631	COG1881	PFAM PEBP family protein
WSWS_01633	COG0514	ATP-dependent DNA helicase (RecQ)
WSWS_01634	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WSWS_01635	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
WSWS_01636	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WSWS_01637	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system