locus_tag old_locus_tag gene Name start end strand product note type ID NCBI WSWS_00001 WSWS_00001 aroA aroA 90 1292 + 3-phosphoshikimate 1-carboxyvinyltransferase Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate%3B Belongs to the EPSP synthase family%3B KEGG: bco:Bcell_1883 3-phosphoshikimate 1-carboxyvinyltransferase gene gene0 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00001 WSWS_00002 WSWS_00002 aroK aroK 1296 1907 + Shikimate kinase Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate%3B Belongs to the shikimate kinase family%3B KEGG: kvu:EIO_1081 shikimate kinase gene gene1 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00002 WSWS_00003 WSWS_00003 WSWS_00003 2198 3577 + Proline-specific permease Required for high-affinity proline transport. Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2. A. 3. 10) family gene gene2 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00003 WSWS_00004 WSWS_00004 rpiA rpiA 3622 4317 - Ribose-5-phosphate isomerase Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate%3B Belongs to the ribose 5-phosphate isomerase family%3B KEGG: yal:AT01_1728 ribose 5-phosphate isomerase A gene gene3 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00004 WSWS_00005 WSWS_00005 WSWS_00005 4466 4774 + hypothetical protein gene gene4 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00005 WSWS_00006 WSWS_00006 mutY mutY 4767 5882 + A/G-specific adenine glycosylase Adenine glycosylase active on G-A and C-A mispairs%3B Belongs to the Nth/MutY family%3B KEGG: lcn:C270_07045 A/G-specific adenine glycosylase%3B Hydrolyzing N-glycosyl compounds gene gene5 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00006 WSWS_00007 WSWS_00007 gidB gidB 6036 6755 + 16S rRNA (guanine(527)-N(7))-methyltransferase Specifically methylates the N7 position of a guanine in 16S rRNA%3B Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family%3B KEGG: wce:WS08_1196 16S rRNA (guanine527-N7)-methyltransferase gene gene6 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00007 WSWS_00008 WSWS_00008 WSWS_00008 6801 7571 + Chromosome partitioning protein ParA Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Belongs to the ParA family gene gene7 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00008 WSWS_00009 WSWS_00009 WSWS_00009 7558 8457 + Stage 0 sporulation protein J Required for the initiation of sporulation and for normal chromosome segregation. Antagonizes sporulation inhibition by Soj. It probably interacts with a specific DNA site and other proteins involved in partitioning and cell division%2C and antagonizes Soj in response to cell cycle events related to chromosome partitioning%3B Belongs to the ParB family gene gene8 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00009 WSWS_00010 WSWS_00010 WSWS_00010 8466 8660 + uncharacterized protein gene gene9 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00010 WSWS_00011 WSWS_00011 WSWS_00011 8676 9779 + Ribosome-binding ATPase YchF ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily%3B Contains 1 OBG-type G (guanine nucleotide-binding) domain gene gene10 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00011 WSWS_00012 WSWS_00012 WSWS_00012 9836 10630 + hypothetical protein gene gene11 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00012 WSWS_00013 WSWS_00013 evgS evgS 10643 11338 + Histidine kinase Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB%2C it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain%3B KEGG: ebi:EbC_18050 two-component system%2C NarL family%2C sensor histidine kinase EvgS gene gene12 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00013 WSWS_00014 WSWS_00014 WSWS_00014 11354 12478 + Sensor histidine kinase YcbM Member of the two-component regulatory system YcbM/YcbL. Probably activates YcbL by phosphorylation%3B Contains 1 histidine kinase domain%3B KEGG: dsy:DSY1785 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene13 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00014 WSWS_00015 WSWS_00015 dacC dacC 12471 13721 + Serine-type D-Ala-D-Ala carboxypeptidase Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. Belongs to the peptidase S11 family%3B KEGG: bif:N288_00085 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5/6) gene gene14 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00015 WSWS_00016 WSWS_00016 WSWS_00016 13833 14351 - hypothetical protein gene gene15 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00016 WSWS_00017 WSWS_00017 WSWS_00017 14453 14872 + hypothetical protein gene gene16 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00017 WSWS_00018 WSWS_00018 WSWS_00018 14967 16196 + hypothetical protein gene gene17 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00018 WSWS_00019 WSWS_00019 WSWS_00019 16296 16370 - tRNA-Gln tRNA gene18 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00019 WSWS_00020 WSWS_00020 WSWS_00020 16381 16463 - tRNA-Tyr tRNA gene19 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00020 WSWS_00021 WSWS_00021 WSWS_00021 16592 16663 - tRNA-Gln tRNA gene20 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00021 WSWS_00022 WSWS_00022 WSWS_00022 16674 16756 - tRNA-Tyr tRNA gene21 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00022 WSWS_00023 WSWS_00023 WSWS_00023 16820 17632 - hypothetical protein gene gene22 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00023 WSWS_00024 WSWS_00024 WSWS_00024 17806 19254 + Di-/tripeptide transporter Proton-dependent uptake of di- or tri-peptides. Belongs to the PTR2/POT transporter (TC 2. A. 17) family gene gene23 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00024 WSWS_00025 WSWS_00025 WSWS_00025 19307 19378 + tRNA-Gln tRNA gene24 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00025 WSWS_00026 WSWS_00026 WSWS_00026 19490 20203 + hypothetical protein gene gene25 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00026 WSWS_00027 WSWS_00027 WSWS_00027 20356 21213 + hypothetical protein gene gene26 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00027 WSWS_00028 WSWS_00028 WSWS_00028 21210 21680 + Protein SprT-like Belongs to the SprT family%3B Contains 1 SprT-like domain gene gene27 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00028 WSWS_00029 WSWS_00029 WSWS_00029 21835 23721 + Putative O-acetyltransferase Belongs to the acyltransferase 3 family%3B KEGG: bra:BRADO5159 null%3B Transferring groups other than amino-acyl groups gene gene28 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00029 WSWS_00030 WSWS_00030 znuC znuC 23819 25450 + Putative ribose/galactose/methyl galactoside import ATP-binding protein Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose%2C galactose and/or methyl galactoside import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Carbohydrate importer 2 (CUT2) (TC 3. A. 1. 2) family%3B Contains 2 ABC transporter domains%3B KEGG: yin:CH53_3805 zinc transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene29 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00030 WSWS_00031 WSWS_00031 WSWS_00031 25573 26913 + putative multidrug resistance protein YpnP Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene30 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00031 WSWS_00032 WSWS_00032 WSWS_00032 27069 28139 + hypothetical protein gene gene31 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00032 WSWS_00033 WSWS_00033 WSWS_00033 28140 28280 + hypothetical protein gene gene32 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00033 WSWS_00034 WSWS_00034 ybaK ybaK 28374 28880 + Putative Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase EbsC Affects the expression of the receptor%2C named binding substance%2C that mediates mating aggregate formation. Could be a regulatory protein that suppresses the function or expression of ebsA and/or ebsMB. Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily%3B KEGG: wko:WKK_03245 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase%3B Carboxylic ester hydrolases gene gene33 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00034 WSWS_00035 WSWS_00035 WSWS_00035 28873 29580 + hypothetical protein gene gene34 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00035 WSWS_00036 WSWS_00036 WSWS_00036 29598 30275 + uncharacterized protein Contains 1 HD domain gene gene35 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00036 WSWS_00037 WSWS_00037 WSWS_00037 30292 31680 + putative MFS-type transporter YhcA Belongs to the major facilitator superfamily. EmrB family gene gene36 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00037 WSWS_00038 WSWS_00038 WSWS_00038 31780 32511 + HTH-type transcriptional regulator GmuR Transcriptional repressor of the gmuBACDREFG operon which is involved in the uptake and degradation of glucomannan%3B Contains 1 HTH gntR-type DNA-binding domain gene gene37 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00038 WSWS_00039 WSWS_00039 WSWS_00039 32691 35144 + Phosphoketolase Belongs to the XFP family%3B KEGG: pgm:PGRAT_01230 xylulose-5-phosphate/fructose-6-phosphate phosphoketolase gene gene38 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00039 WSWS_00040 WSWS_00040 thiD thiD 35316 36125 + Hydroxymethylpyrimidine kinase Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP%2C and of HMP to HMP-P. Shows no activity with pyridoxal%2C pyridoxamine or pyridoxine. Belongs to the ThiD family%3B KEGG: lpr:LBP_cg0091 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase gene gene39 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00040 WSWS_00041 WSWS_00041 WSWS_00041 36291 37013 + hypothetical protein gene gene40 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00041 WSWS_00042 WSWS_00042 gntK gntK 37057 37758 + Gluconokinase KEGG: wko:WKK_05810 gluconokinase gene gene41 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00042 WSWS_00043 WSWS_00043 xthA xthA 38135 38953 + Exodeoxyribonuclease III In addition to 3'- to 5'-exonuclease and 3'-phosphatase activities%2C ExoA was shown to make single-strand breaks at apurinic sites in DNA%3B Belongs to the DNA repair enzymes AP/ExoA family%3B KEGG: spy:SPy_0412 exodeoxyribonuclease III gene gene42 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00043 WSWS_00044 WSWS_00044 WSWS_00044 39122 39868 + Energy-dependent translational throttle protein EttA A translation factor that gates the progression of the 70S ribosomal inititation complex (IC%2C containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation (By similarity)%3B Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily%3B Contains 2 ABC transporter domains gene gene43 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00044 WSWS_00045 WSWS_00045 WSWS_00045 39861 41642 + Manganese transport system membrane protein MntC This protein is probably a component of a manganese permease%2C a binding protein-dependent%2C ATP-driven transport system%3B Belongs to the ABC-3 integral membrane protein family gene gene44 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00045 WSWS_00046 WSWS_00046 WSWS_00046 41753 41824 - tRNA-Glu tRNA gene45 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00046 WSWS_00047 WSWS_00047 WSWS_00047 42078 43913 + putative amino acid permease YdaO Belongs to the amino acid-polyamine-organocation (APC) superfamily gene gene46 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00047 WSWS_00048 WSWS_00048 WSWS_00048 44064 45050 + hypothetical protein gene gene47 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00048 WSWS_00049 WSWS_00049 WSWS_00049 45180 46328 + D-alanine--D-alanine ligase Cell wall formation%3B Belongs to the D-alanine--D-alanine ligase family%3B Contains 1 ATP-grasp domain%3B KEGG: mop:Mesop_3337 D-alanine-D-alanine ligase gene gene48 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00049 WSWS_00050 WSWS_00050 WSWS_00050 46434 47039 + Thymidine kinase Belongs to the thymidine kinase family%3B KEGG: bcl:ABC3877 thymidine kinase gene gene49 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00050 WSWS_00051 WSWS_00051 WSWS_00051 47064 48143 + Peptide chain release factor Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA%3B Belongs to the prokaryotic/mitochondrial release factor family gene gene50 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00051 WSWS_00052 WSWS_00052 hemK hemK 48153 49007 + Peptide chain release factor N(5)-glutamine methyltransferase Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif%3B Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily%3B KEGG: wko:WKK_02920 release factor glutamine methyltransferase gene gene51 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00052 WSWS_00053 WSWS_00053 tsaC tsaC 49035 50060 + L-threonylcarbamoyladenylate synthase Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine%2C HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate%2C with the release of diphosphate%3B Belongs to the SUA5 family. TsaC subfamily%3B Contains 1 YrdC-like domain%3B KEGG: lmu:LBLM1_08650 L-threonylcarbamoyladenylate synthase gene gene52 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00053 WSWS_00054 WSWS_00054 glyA glyA 50219 51466 + Glycine hydroxymethyltransferase Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines%2C thymidylate%2C methionine%2C and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids%2C producing glycine and aldehydes%2C via a retro-aldol mechanism%3B Belongs to the SHMT family%3B KEGG: lbr:LVIS_1287 glycine hydroxymethyltransferase gene gene53 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00054 WSWS_00055 WSWS_00055 WSWS_00055 51715 54807 + Bacteriophage SPP1 adsorption protein YueB Bacteriophage SPP1 receptor. Essential for the irreversible adsorption of the bacteriophage gene gene54 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00055 WSWS_00056 WSWS_00056 uprT uprT 54931 55560 + Uracil phosphoribosyltransferase Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate%3B Belongs to the UPRTase family%3B KEGG: wko:WKK_02905 uracil phosphoribosyltransferase gene gene55 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00056 WSWS_00057 WSWS_00057 WSWS_00057 55835 57118 + Uracil permease Transport of uracil in the cell. Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2. A. 40) subfamily gene gene56 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00057 WSWS_00058 WSWS_00058 WSWS_00058 57371 58087 + ATP synthase subunit Key component of the proton channe%3B it plays a direct role in the translocation of protons across the membrane%3B Belongs to the ATPase A chain family gene gene57 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00058 WSWS_00059 WSWS_00059 WSWS_00059 58171 58395 + ATP synthase subunit F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B Key component of the F(0) channe%3B it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits%3B Belongs to the ATPase C chain family gene gene58 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00059 WSWS_00060 WSWS_00060 WSWS_00060 58434 58955 + ATP synthase subunit F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B Component of the F(0) channel%2C it forms part of the peripheral stalk%2C linking F(1) to F(0)%3B Belongs to the ATPase B chain family gene gene59 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00060 WSWS_00061 WSWS_00061 WSWS_00061 58955 59500 + ATP synthase subunit delta F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction%3B Belongs to the ATPase delta chain family gene gene60 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00061 WSWS_00062 WSWS_00062 atpA atpA 59573 61087 + H(+)-transporting two-sector ATPase Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit%3B Belongs to the ATPase alpha/beta chains family%3B KEGG: hhm:BN341_p0008 F-type H+-transporting ATPase subunit alpha gene gene61 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00062 WSWS_00063 WSWS_00063 WSWS_00063 61104 61982 + ATP synthase gamma chain Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex%3B Belongs to the ATPase gamma chain family gene gene62 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00063 WSWS_00064 WSWS_00064 atpD atpD 62027 63427 + H(+)-transporting two-sector ATPase Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits%3B Belongs to the ATPase alpha/beta chains family%3B KEGG: lpl:lp_2364 F-type H+-transporting ATPase subunit beta gene gene63 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00064 WSWS_00065 WSWS_00065 WSWS_00065 63440 63874 + ATP synthase epsilon chain Produces ATP from ADP in the presence of a proton gradient across the membrane%3B Belongs to the ATPase epsilon chain family gene gene64 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00065 WSWS_00066 WSWS_00066 WSWS_00066 64019 64672 + Deoxyadenosine kinase Specific kinase that phosphorylates deoxyadenosine but not any other deoxyribonucleoside%2C as part of the deoxyribonucleotide salvage pathway. Belongs to the DCK/DGK family%3B KEGG: ljo:LJ1824 deoxyadenosine kinase gene gene65 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00066 WSWS_00067 WSWS_00067 sarS sarS 64685 65968 + Serine--tRNA ligase Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine%2C to form the misacylated tRNA L-seryl-tRNA(Sec)%2C which will be further converted into selenocysteinyl-tRNA(Sec)%3B Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily%3B KEGG: dak:DaAHT2_1969 seryl-tRNA synthetase gene gene66 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00067 WSWS_00068 WSWS_00068 WSWS_00068 66139 66221 + tRNA-Leu tRNA gene67 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00068 WSWS_00069 WSWS_00069 WSWS_00069 66250 66322 + tRNA-Thr tRNA gene68 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00069 WSWS_00070 WSWS_00070 WSWS_00070 66361 66434 + tRNA-Arg tRNA gene69 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00070 WSWS_00071 WSWS_00071 WSWS_00071 66644 69136 + putative ATP-dependent Clp protease ATP-binding subunit Belongs to the ClpA/ClpB family. ClpC subfamily%3B Contains 1 UVR domain gene gene70 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00071 WSWS_00072 WSWS_00072 rpoB rpoB 69437 73021 + DNA-directed RNA polymerase DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase beta chain family%3B KEGG: wce:WS08_1123 DNA-directed RNA polymerase subunit beta gene gene71 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00072 WSWS_00073 WSWS_00073 rpoC rpoC 73172 76861 + DNA-directed RNA polymerase DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase beta' chain family%3B KEGG: bci:BCI_0503 DNA-directed RNA polymerase subunit beta' gene gene72 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00073 WSWS_00074 WSWS_00074 WSWS_00074 77149 78204 + hypothetical protein gene gene73 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00074 WSWS_00075 WSWS_00075 WSWS_00075 78302 79153 + hypothetical protein gene gene74 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00075 WSWS_00076 WSWS_00076 WSWS_00076 79247 80194 - Transcriptional regulator LytR Attenuator role for operon expression%3B Belongs to the LytR/CpsA/Psr regulatory protein family gene gene75 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00076 WSWS_00077 WSWS_00077 metK metK 80538 81728 + Methionine adenosyltransferase Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps%2C AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme%3B Belongs to the AdoMet synthase family%3B KEGG: baco:OXB_0001 S-adenosylmethionine synthetase gene gene76 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00077 WSWS_00078 WSWS_00078 WSWS_00078 81743 82150 + Peptide deformylase Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)%3B Belongs to the polypeptide deformylase family%3B KEGG: pbd:PBOR_10450 peptide deformylase gene gene77 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00078 WSWS_00079 WSWS_00079 pepN pepN 82339 84879 + Membrane alanyl aminopeptidase Aminopeptidase with broad substrate specificity to several peptides. It has more affinity for oligopeptides than for dipeptides. It plays an essential role in the metabolism%2C it may be involved in nitrogen supply or protein turnover. Belongs to the peptidase M1 family%3B KEGG: stc:str1007 aminopeptidase N gene gene78 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00079 WSWS_00080 WSWS_00080 rumA rumA 84996 86387 + 23S rRNA (uracil(1939)-C(5))-methyltransferase Catalyzes the formation of 5-methyl-uridine at positions 747 (m5U747) and 1939 (m5U1939) in 23S rRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family%3B Contains 1 TRAM domain%3B KEGG: gyc:GYMC61_1225 23S rRNA (uracil1939-C5)-methyltransferase gene gene79 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00080 WSWS_00081 WSWS_00081 WSWS_00081 86445 86960 - hypothetical protein gene gene80 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00081 WSWS_00082 WSWS_00082 bcrC bcrC 86944 87615 - Undecaprenyl-diphosphate phosphatase KEGG: paea:R70723_13825 undecaprenyl-diphosphatase gene gene81 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00082 WSWS_00083 WSWS_00083 larS larS 87742 90207 + Leucine--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: dvu:DVU1196 leucyl-tRNA synthetase gene gene82 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00083 WSWS_00084 WSWS_00084 WSWS_00084 90270 90824 - hypothetical protein gene gene83 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00084 WSWS_00085 WSWS_00085 WSWS_00085 90966 91625 + dTMP kinase Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis%3B Belongs to the thymidylate kinase family%3B KEGG: lsl:LSL_1224 dTMP kinase gene gene84 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00085 WSWS_00086 WSWS_00086 WSWS_00086 91622 91951 + uncharacterized protein gene gene85 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00086 WSWS_00087 WSWS_00087 holB holB 91981 92991 + DNA-directed DNA polymerase KEGG: lho:LOOC260_117280 DNA polymerase III subunit delta' gene gene86 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00087 WSWS_00088 WSWS_00088 rsmI rsmI 92993 93871 + 16S rRNA (cytidine(1402)-2'-O)-methyltransferase Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA%3B Belongs to the methyltransferase superfamily. RsmI family%3B KEGG: bbe:BBR47_00830 16S rRNA (cytidine1402-2'-O)-methyltransferase gene gene87 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00088 WSWS_00089 WSWS_00089 WSWS_00089 93871 94608 + Dodecanoyl-[acyl-carrier-protein] hydrolase KEGG: thl:TEH_09530 medium-chain acyl-(acyl-carrier-protein) hydrolase gene gene88 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00089 WSWS_00090 WSWS_00090 galE galE 94664 95659 + UDP-glucose 4-epimerase Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity)%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: sbg:SBG_1909 UDP-glucose 4-epimerase gene gene89 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00090 WSWS_00091 WSWS_00091 WSWS_00091 95846 96577 + tRNA threonylcarbamoyladenosine biosynthesis protein TsaB Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37%2C together with TsaD and Tsa%3B this reaction does not require ATP in vitro. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway%2C possibly in regulating the core enzymatic function of TsaD%3B Belongs to the KAE1 / TsaD family. TsaB subfamily gene gene90 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00091 WSWS_00092 WSWS_00092 rimI rimI 96549 97142 + Ribosomal-protein-alanine N-acetyltransferase This enzyme acetylates the N-terminal alanine of ribosomal protein S18%3B Belongs to the acetyltransferase family. RimI subfamily%3B Contains 1 N-acetyltransferase domain%3B KEGG: wko:WKK_02820 ribosomal-protein-alanine N-acetyltransferase%3B overlaps another CDS with the same product name gene gene91 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00092 WSWS_00093 WSWS_00093 WSWS_00093 97123 97572 + Ribosomal-protein-alanine N-acetyltransferase KEGG: css:Cst_c26470 ribosomal-protein-alanine N-acetyltransferase%3B overlaps another CDS with the same product name gene gene92 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00093 WSWS_00094 WSWS_00094 kae1 kae1 97572 98618 + N(6)-L-threonylcarbamoyladenine synthase Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37%2C together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction%3B Belongs to the KAE1 / TsaD family%3B KEGG: lgy:T479_21305 N6-L-threonylcarbamoyladenine synthase gene gene93 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00094 WSWS_00095 WSWS_00095 WSWS_00095 98665 99657 - Heptaprenyl diphosphate synthase Probably involved in biosynthesis of the precursor for C25 (sesterterpanyl chain) moiety of C25-C25 diether (2%2C3-di-O- sesterterpanyl-sn-glycero) membrane lipid. Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield all-trans geranylfarnesyl diphosphate (GFPP). Geranylgeranyl diphosphate (GGPP) is the preferred substrate%2C however methylallyl diphosphate (DMAPP)%2C farnesyl diphosphate (FPP) and geranyl diphosphate (GPP) can also be used as allylic substrate%3B Belongs to the FPP/GGPP synthase family%3B KEGG: axl:AXY_00680 heptaprenyl diphosphate synthase gene gene94 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00095 WSWS_00096 WSWS_00096 WSWS_00096 100051 100359 + 30S ribosomal protein S10 Involved in the binding of tRNA to the ribosomes%3B Belongs to the ribosomal protein S10P family gene gene95 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00096 WSWS_00097 WSWS_00097 WSWS_00097 100457 101083 + 50S ribosomal protein L3 One of the primary rRNA binding proteins%2C it binds directly near the 3'-end of the 23S rRNA%2C where it nucleates assembly of the 50S subunit%3B Belongs to the ribosomal protein L3P family gene gene96 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00097 WSWS_00098 WSWS_00098 WSWS_00098 101108 101731 + 50S ribosomal protein L4 One of the primary rRNA binding proteins%2C this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome%3B Forms part of the polypeptide exit tunnel%3B Belongs to the ribosomal protein L4P family gene gene97 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00098 WSWS_00099 WSWS_00099 WSWS_00099 101731 102018 + 50S ribosomal protein L23 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome%3B Belongs to the ribosomal protein L23P family gene gene98 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00099 WSWS_00100 WSWS_00100 WSWS_00100 102035 102868 + 50S ribosomal protein L2 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome%2C for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activit%3B this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome%3B Belongs to the ribosomal protein L2P family gene gene99 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00100 WSWS_00101 WSWS_00101 WSWS_00101 102923 103204 + 30S ribosomal protein S19%2C chloroplastic Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA%3B Belongs to the ribosomal protein S19P family gene gene100 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00101 WSWS_00102 WSWS_00102 WSWS_00102 103222 103569 + 50S ribosomal protein L22 This protein binds specifically to 23S rRN%3B its binding is stimulated by other ribosomal proteins%2C e. g. L4%2C L17%2C and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)%3B The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit%2C while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome%3B Belongs to the ribosomal protein L22P family gene gene101 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00102 WSWS_00103 WSWS_00103 WSWS_00103 103583 104248 + 30S ribosomal protein S3 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome%2C positioning it for translation%3B Belongs to the ribosomal protein S3P family%3B Contains 1 KH type-2 domain gene gene102 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00103 WSWS_00104 WSWS_00104 WSWS_00104 104250 104669 + 50S ribosomal protein L16%2C plastid Belongs to the ribosomal protein L16P family gene gene103 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00104 WSWS_00105 WSWS_00105 WSWS_00105 104669 104875 + 50S ribosomal protein L29 Belongs to the ribosomal protein L29P family gene gene104 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00105 WSWS_00106 WSWS_00106 WSWS_00106 104896 105162 + 30S ribosomal protein S17 One of the primary rRNA binding proteins%2C it binds specifically to the 5'-end of 16S ribosomal RNA%3B Belongs to the ribosomal protein S17P family gene gene105 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00106 WSWS_00107 WSWS_00107 WSWS_00107 105208 105576 + 50S ribosomal protein L14 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome%3B Belongs to the ribosomal protein L14P family gene gene106 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00107 WSWS_00108 WSWS_00108 WSWS_00108 105609 105914 + 50S ribosomal protein L24 One of two assembly initiator proteins%2C it binds directly to the 5'-end of the 23S rRNA%2C where it nucleates assembly of the 50S subunit%3B One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit%3B Belongs to the ribosomal protein L24P family gene gene107 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00108 WSWS_00109 WSWS_00109 WSWS_00109 105944 106486 + 50S ribosomal protein L5 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit%2C where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b)%2C connecting the 2 subunit%3B this bridge is implicated in subunit movement. Contacts the P site tRN%3B the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs%3B Belongs to the ribosomal protein L5P family gene gene108 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00109 WSWS_00110 WSWS_00110 WSWS_00110 106537 106935 + 30S ribosomal protein S8 One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit%3B Belongs to the ribosomal protein S8P family gene gene109 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00110 WSWS_00111 WSWS_00111 WSWS_00111 106966 107502 + 50S ribosomal protein L6%2C cyanelle Binds 23S rRNA%3B Belongs to the ribosomal protein L6P family gene gene110 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00111 WSWS_00112 WSWS_00112 WSWS_00112 107703 108059 + 50S ribosomal protein L18 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit%2C where it forms part of the central protuberance%3B Belongs to the ribosomal protein L18P family gene gene111 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00112 WSWS_00113 WSWS_00113 WSWS_00113 108080 108583 + 30S ribosomal protein With S4 and S12 plays an important role in translational accuracy%3B Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body%3B Belongs to the ribosomal protein S5P family%3B Contains 1 S5 DRBM domain gene gene112 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00113 WSWS_00114 WSWS_00114 WSWS_00114 108596 108781 + 50S ribosomal protein L30 Belongs to the ribosomal protein L30P family gene gene113 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00114 WSWS_00115 WSWS_00115 WSWS_00115 108814 109248 + 50S ribosomal protein L15 Binds to the 23S rRNA%3B Belongs to the ribosomal protein L15P family gene gene114 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00115 WSWS_00116 WSWS_00116 WSWS_00116 109248 110555 + Protein translocase subunit SecY The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7%2C and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently%3B Belongs to the SecY/SEC61-alpha family gene gene115 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00116 WSWS_00117 WSWS_00117 WSWS_00117 110552 111121 + Adenylate kinase Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism%3B Belongs to the adenylate kinase family%3B KEGG: rsk:RSKD131_0035 adenylate kinase gene gene116 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00117 WSWS_00118 WSWS_00118 WSWS_00118 111213 111428 + Translation initiation factor IF-1 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection%2C yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1%2C IF-2 and IF-3 are released leaving the mature 70S translation initation complex%3B Belongs to the IF-1 family%3B Contains 1 S1-like domain gene gene117 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00118 WSWS_00119 WSWS_00119 WSWS_00119 111466 111582 + 50S ribosomal protein L36%2C chloroplastic Belongs to the ribosomal protein L36P family gene gene118 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00119 WSWS_00120 WSWS_00120 WSWS_00120 111656 112021 + Cyanelle 30S ribosomal protein S13 Located at the top of the head of the 30S subunit%2C it contacts several helices of the 16S rRNA%3B Belongs to the ribosomal protein S13P family gene gene119 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00120 WSWS_00121 WSWS_00121 WSWS_00121 112056 112442 + 30S ribosomal protein S11 Located on the platform of the 30S subunit%2C it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome%3B Belongs to the ribosomal protein S11P family gene gene120 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00121 WSWS_00122 WSWS_00122 rpoA rpoA 112498 113442 + DNA-directed RNA polymerase DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase alpha chain family%3B KEGG: lla:L0136 DNA-directed RNA polymerase subunit alpha gene gene121 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00122 WSWS_00123 WSWS_00123 WSWS_00123 113517 113903 + 50S ribosomal protein L17 Belongs to the ribosomal protein L17P family gene gene122 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00123 WSWS_00124 WSWS_00124 WSWS_00124 114444 115124 - Vacuolar iron transporter like protein Probable vacuolar iron transporter that may be involved in the regulation of iron distribution throughout the plant%3B Belongs to the CCC1 family gene gene123 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00124 WSWS_00125 WSWS_00125 WSWS_00125 115126 115800 - Nodulin-21 May play an important role in symbiotic nitrogen fixation. Belongs to the CCC1 family gene gene124 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00125 WSWS_00126 WSWS_00126 doxD doxD 116378 116902 + Thiosulfate dehydrogenase (quinone) KEGG: wce:WS08_0662 thiosulfate dehydrogenase (quinone) large subunit gene gene125 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00126 WSWS_00127 WSWS_00127 WSWS_00127 117053 118339 + Putative UV-damage repair protein UvrX Belongs to the DNA polymerase type-Y family%3B Contains 1 umuC domain gene gene126 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00127 WSWS_00128 WSWS_00128 WSWS_00128 118332 118724 + hypothetical protein gene gene127 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00128 WSWS_00129 WSWS_00129 WSWS_00129 118780 119475 - D-methionine transport system permease protein MetI Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl- methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene128 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00129 WSWS_00130 WSWS_00130 WSWS_00130 119475 120545 - Macrolide export ATP-binding/permease protein MacB Non-canonical ABC transporter that contains transmembrane domains (TMD)%2C which form a pore in the inner membrane%2C and an ATP-binding domain (NBD)%2C which is responsible for energy generation. Confers resistance against macrolides%3B Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3. A. 1. 122) family%3B Contains 1 ABC transporter domain gene gene129 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00130 WSWS_00131 WSWS_00131 WSWS_00131 120737 121567 - D-methionine-binding lipoprotein MetQ This protein is a component of a D-methionine permease%2C a binding protein-dependent%2C ATP-driven transport system%3B Belongs to the NlpA lipoprotein family gene gene130 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00131 WSWS_00132 WSWS_00132 WSWS_00132 122025 122696 - hypothetical protein gene gene131 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00132 WSWS_00133 WSWS_00133 pncB pncB 122875 124362 + Nicotinate phosphoribosyltransferase Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN)%3B Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP%3B Belongs to the NAPRTase family%3B KEGG: pste:PSTEL_16945 nicotinate phosphoribosyltransferase gene gene132 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00133 WSWS_00134 WSWS_00134 nadE nadE 124380 125204 + NAD(+) synthase Belongs to the NAD synthetase family%3B KEGG: bco:Bcell_2157 NAD+ synthase gene gene133 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00134 WSWS_00135 WSWS_00135 carS carS 125393 126802 + Cysteine--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: eco:b0526 cysteinyl-tRNA synthetase gene gene134 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00135 WSWS_00136 WSWS_00136 WSWS_00136 126938 127366 + Mini-ribonuclease Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc%3B Rnc processes 30S rRNA into smaller rRNA precursors. Cleaves more efficiently on assembled 50S ribosomal subunits. Cleavage is strongly stimulated by ribosomal protein L3 (RplC%3B 20-30%25 DMSO can replace RplC%2C suggesting RplC may alter rRNA conformation%3B Belongs to the MrnC RNase family%3B KEGG: lsl:LSL_1246 ribonuclease III family protein%3B Endoribonucleases producing 5'-phosphomonoesters gene gene135 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00136 WSWS_00137 WSWS_00137 rlmB rlmB 127347 128198 + 23S rRNA (guanosine(2251)-2'-O)-methyltransferase Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family%3B KEGG: tap:GZ22_17700 23S rRNA (guanosine2251-2'-O)-methyltransferase gene gene136 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00137 WSWS_00138 WSWS_00138 WSWS_00138 128301 128831 + hypothetical protein gene gene137 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00138 WSWS_00139 WSWS_00139 WSWS_00139 128947 129096 + 50S ribosomal protein L33 Belongs to the ribosomal protein L33P family gene gene138 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00139 WSWS_00140 WSWS_00140 WSWS_00140 129113 129283 + hypothetical protein gene gene139 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00140 WSWS_00141 WSWS_00141 WSWS_00141 129381 129947 + Transcription termination/antitermination protein NusG Participates in transcription elongation%2C termination and antitermination%3B Belongs to the NusG family%3B Contains 1 KOW domain gene gene140 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00141 WSWS_00142 WSWS_00142 WSWS_00142 130124 130549 + 50S ribosomal protein L11 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors%3B Belongs to the ribosomal protein L11P family gene gene141 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00142 WSWS_00143 WSWS_00143 WSWS_00143 130682 131374 + 50S ribosomal protein L1 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome%2C and is involved in E site tRNA release%3B Protein L1 is also a translational repressor protein%2C it controls the translation of the L11 operon by binding to its mRNA%3B Belongs to the ribosomal protein L1P family gene gene142 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00143 WSWS_00144 WSWS_00144 WSWS_00144 131875 132432 + Protein YtsP Belongs to the free Met sulfoxide reductase family gene gene143 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00144 WSWS_00145 WSWS_00145 pdhD pdhD 132517 133866 + Dihydrolipoyl dehydrogenase Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: asg:FB03_01315 dihydrolipoamide dehydrogenase gene gene144 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00145 WSWS_00146 WSWS_00146 WSWS_00146 133940 134893 + putative oxidoreductase YcsN Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily%3B KEGG: lsl:LSL_0712 null%3B With NAD(+) or NADP(+) as acceptor gene gene145 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00146 WSWS_00147 WSWS_00147 WSWS_00147 135033 135293 + hypothetical protein gene gene146 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00147 WSWS_00148 WSWS_00148 WSWS_00148 135495 136001 + 50S ribosomal protein L10 Forms part of the ribosomal stalk%2C playing a central role in the interaction of the ribosome with GTP-bound translation factors%3B Belongs to the ribosomal protein L10P family gene gene147 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00148 WSWS_00149 WSWS_00149 WSWS_00149 136092 136457 + 50S ribosomal protein L7/L12 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation%3B Belongs to the ribosomal protein L7/L12P family gene gene148 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00149 WSWS_00150 WSWS_00150 msrA msrA 136638 137453 + Peptide-methionine (S)-S-oxide reductase Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)%3B Belongs to the MsrA Met sulfoxide reductase family%3B KEGG: lcb:LCABL_14210 peptide-methionine (S)-S-oxide reductase gene gene149 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00150 WSWS_00151 WSWS_00151 bglA bglA 137602 139083 + 6-phospho-beta-glucosidase Catalyzes the hydrolysis of aryl-phospho-beta-D- glucosides such as 4-methylumbelliferyl-phospho-beta-D- glucopyranoside (MUG-P)%2C phosphoarbutin and phosphosalicin. Plays a major role in the utilization of arbutin or salicin as the sole carbon source. BglA and BglH are the major proteins contributing to hydrolysis of MUG-P by extracts of late-exponential-phase or stationary-phase B. subtilis cells%3B Belongs to the glycosyl hydrolase 1 family%3B KEGG: ljf:FI9785_265 6-phospho-beta-glucosidase gene gene150 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00151 WSWS_00152 WSWS_00152 WSWS_00152 139310 140623 + Cellobiose permease IIC component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in cellobiose transport. Contains 1 PTS EIIC type-3 domain gene gene151 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00152 WSWS_00153 WSWS_00153 celA celA 140733 141050 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in lichenan transport. Contains 1 PTS EIIB type-3 domain%3B KEGG: ssp:SSP0240 PTS system%2C cellobiose-specific IIB component gene gene152 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00153 WSWS_00154 WSWS_00154 celC celC 141165 141563 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N%2CN'-diacetylchitobiose transport (By similarity)%3B Contains 1 PTS EIIA type-3 domain%3B KEGG: lsa:LSA1533 PTS system%2C cellobiose-specific IIA component gene gene153 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00154 WSWS_00155 WSWS_00155 WSWS_00155 141560 143074 + 6-phospho-beta-glucosidase LPH splits lactose in the small intestine. Belongs to the glycosyl hydrolase 1 family%3B KEGG: pce:PECL_141 6-phospho-beta-glucosidase gene gene154 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00155 WSWS_00156 WSWS_00156 ribB ribB 143164 143805 - 3%2C4-dihydroxy-2-butanone-4-phosphate synthase Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3%2C4-dihydroxy-2-butanone 4-phosphate%3B Catalyzes the conversion of GTP to 2%2C5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP)%2C formate and pyrophosphate%3B In the N-terminal sectio%3B belongs to the DHBP synthase family%3B In the C-terminal sectio%3B belongs to the GTP cyclohydrolase II family%3B KEGG: ttt:THITE_2109828 3%2C4-dihydroxy 2-butanone 4-phosphate synthase gene gene155 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00156 WSWS_00157 WSWS_00157 acpS acpS 144100 145596 + Holo-[acyl-carrier-protein] synthase Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein%3B Belongs to the P-Pant transferase superfamily. AcpS family%3B KEGG: lpl:lp_0522 holo-(acyl-carrier protein) synthase gene gene156 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00157 WSWS_00158 WSWS_00158 mazF mazF 145642 146004 + Endoribonuclease EndoA Toxic component of a type II toxin-antitoxin (TA) module. Specific for 5'-UACAU-3' sequences%2C cleaving after the first U (PubMed:21763692). Yields cleavage products with 3' phosphate and 5' hydroxyl groups (PubMed:15882409). Cannot digest substrate with a UUdUACAUAA cleavage site (PubMed:24120662). Overexpression is toxic for cell growth (shown in E. coli)%2C probably by inhibiting protein synthesis through the cleavage of single-stranded RNA. The toxicity is reversed by the antitoxin EndoAI. Toxin activity cannot be inhibited by MazE from E. coli. The EndoA-EndoAI complex does not seem to bind its own promoter (PubMed:24120662)%3B Belongs to the PemK/MazF family%3B KEGG: ppe:PEPE_1557 mRNA interferase MazF%3B Acting on ester bonds gene gene157 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00158 WSWS_00159 WSWS_00159 WSWS_00159 146081 147268 - Synaptic vesicle 2-related protein Belongs to the major facilitator superfamily gene gene158 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00159 WSWS_00160 WSWS_00160 WSWS_00160 147355 147867 - Transcription repressor NadR In the presence of nicotinic acid represses transcription of the nadBCA and nifS-nadR operons. Also binds to DNA upstream of the niaP gene%2C probably regulating it as well. May bind nicotinic acid gene gene159 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00160 WSWS_00161 WSWS_00161 WSWS_00161 148023 149399 + Glutathione-disulfide reductase Lipoamide dehydrogenase is an essential component of the pyruvate dehydrogenase (PDH) and 2-oxoglutarate dehydrogenase (ODH) complexes. Catalyzes the reoxidation of dihydrolipoyl groups which are covalently attached to the lipoate acyltransferase components (E2) of the complexes. Also catalyzes a reversible NADH:NAD(+) transhydrogenation%2C and is able to transfer electrons from NADH to various redox-active compounds and quinones. May be involved in quinone redox cycling in C. glutamicum%3B Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: rhd:R2APBS1_1848 glutathione reductase (NADPH) gene gene160 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00161 WSWS_00162 WSWS_00162 uvrD uvrD 149509 151821 + DNA helicase Catalyzes the unwinding of duplex DNA in the 3' to 5' directio%3B this reaction is dependent on the hydrolysis of ATP%3B Belongs to the helicase family. UvrD subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B KEGG: bay:RBAM_030620 DNA helicase II / ATP-dependent DNA helicase PcrA gene gene161 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00162 WSWS_00163 WSWS_00163 warS warS 151910 152911 + Tryptophan--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: sty:STY4863 tryptophanyl-tRNA synthetase gene gene162 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00163 WSWS_00164 WSWS_00164 WSWS_00164 152915 153847 + Exopolyphosphatase KEGG: lme:LEUM_0334 exopolyphosphatase / guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase gene gene163 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00164 WSWS_00165 WSWS_00165 ldhA ldhA 153993 154991 + D-lactate dehydrogenase Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B KEGG: tpl:TPCCA_0037 D-lactate dehydrogenase gene gene164 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00165 WSWS_00166 WSWS_00166 WSWS_00166 155182 156807 + Glutathione-binding protein GsiB Part of the ABC transporter complex GsiABCD involved in glutathione import%3B Belongs to the bacterial solute-binding protein 5 family gene gene165 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00166 WSWS_00167 WSWS_00167 WSWS_00167 157153 158514 + Gnt-II system L-idonate transporter Transports L-idonate%2C D-gluconate and 5-keto-D- gluconate%2C from the periplasm across the inner membrane%3B Belongs to the GntP permease family gene gene166 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00167 WSWS_00168 WSWS_00168 adhE adhE 158858 161569 + Acetaldehyde dehydrogenase (acetylating) KEGG: lci:LCK_00119 acetaldehyde dehydrogenase / alcohol dehydrogenase gene gene167 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00168 WSWS_00169 WSWS_00169 WSWS_00169 161715 162485 + putative tRNA/rRNA methyltransferase YsgA Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family gene gene168 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00169 WSWS_00170 WSWS_00170 WSWS_00170 162520 162990 + hypothetical protein gene gene169 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00170 WSWS_00171 WSWS_00171 rluE rluE 163129 163665 + 23S rRNA pseudouridine(2457) synthase Responsible for synthesis of pseudouridine from uracil- 2457 in 23S ribosomal RNA%3B Belongs to the pseudouridine synthase RsuA family%3B KEGG: hdu:HD0337 23S rRNA pseudouridine2457 synthase gene gene170 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00171 WSWS_00172 WSWS_00172 WSWS_00172 163909 164253 + putative HTH-type transcriptional regulator Contains 1 HTH hxlR-type DNA-binding domain gene gene171 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00172 WSWS_00173 WSWS_00173 WSWS_00173 164374 165153 + hypothetical protein gene gene172 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00173 WSWS_00174 WSWS_00174 WSWS_00174 165247 166086 + hypothetical protein gene gene173 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00174 WSWS_00175 WSWS_00175 WSWS_00175 166278 166403 - hypothetical protein gene gene174 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00175 WSWS_00176 WSWS_00176 WSWS_00176 166553 167272 - putative membrane protein YceF Belongs to the TerC family gene gene175 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00176 WSWS_00177 WSWS_00177 WSWS_00177 167551 169194 + NADH dehydrogenase Alternative NADH-ubiquinone oxidoreductase which catalyzes the oxidation of mitochondrial NADH does not translocate protons across the inner mitochondrial membrane%3B Belongs to the NADH dehydrogenase family%3B KEGG: ssv:SSU98_1768 NADH dehydrogenase gene gene176 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00177 WSWS_00178 WSWS_00178 WSWS_00178 169536 170489 + putative membrane protein Belongs to the TerC family gene gene177 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00178 WSWS_00179 WSWS_00179 dapE dapE 170626 172053 + Succinyl-diaminopimelate desuccinylase Belongs to the peptidase M20A family%3B KEGG: afl:Aflv_0432 succinyl-diaminopimelate desuccinylase gene gene178 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00179 WSWS_00180 WSWS_00180 addB addB 172184 175732 + ATP-dependent helicase/deoxyribonuclease subunit B The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent%2C dual-direction single-stranded exonuclease. This subunit has 5' -> 3' nuclease activity%3B Belongs to the helicase family. AddB/RexB type 2 subfamily%3B KEGG: wko:WKK_02555 ATP-dependent helicase/nuclease subunit B%3B Acting on ester bonds gene gene179 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00180 WSWS_00181 WSWS_00181 addA addA 175732 179550 + ATP-dependent helicase/nuclease subunit The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent%2C dual-direction single-stranded exonuclease%3B this subunit has the helicase and 3' -> 5' nuclease activities%3B Belongs to the helicase family. AddA subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B Contains 1 uvrD-like helicase C-terminal domain%3B KEGG: ctet:BN906_00747 ATP-dependent helicase/nuclease subunit A%3B Acting on ester bonds gene gene180 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00181 WSWS_00182 WSWS_00182 adhP adhP 179711 180763 + Alcohol dehydrogenase Belongs to the zinc-containing alcohol dehydrogenase family%3B KEGG: ooe:OEOE_0527 alcohol dehydrogenase%2C propanol-preferring gene gene181 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00182 WSWS_00183 WSWS_00183 WSWS_00183 180788 182011 - putative MFS-type transporter YttB Belongs to the major facilitator superfamily gene gene182 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00183 WSWS_00184 WSWS_00184 glpK glpK 182156 183694 + Glycerol kinase Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate%3B Belongs to the FGGY kinase family%3B KEGG: shd:SUTH_02804 glycerol kinase gene gene183 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00184 WSWS_00185 WSWS_00185 g6pD g6pD 183816 185276 + Glucose-6-phosphate dehydrogenase (NADP(+)) Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. Can utilize either NADP(+) or NAD(+)%3B Belongs to the glucose-6-phosphate dehydrogenase family%3B KEGG: lci:LCK_00052 glucose-6-phosphate 1-dehydrogenase gene gene184 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00185 WSWS_00186 WSWS_00186 WSWS_00186 185536 186384 + Pur operon repressor Controls the transcription of the pur operon for purine biosynthetic genes%2C binds to the control region of the operon. DNA binding is inhibited by 5-phosphoribosyl 1-pyrophosphate. Belongs to the purine/pyrimidine phosphoribosyltransferase family gene gene185 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00186 WSWS_00187 WSWS_00187 glmU glmU 186406 187794 + UDP-N-acetylglucosamine diphosphorylase Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P)%2C which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate)%2C a reaction catalyzed by the N-terminal domain%3B In the N-terminal sectio%3B belongs to the N- acetylglucosamine-1-phosphate uridyltransferase family%3B In the C-terminal sectio%3B belongs to the transferase hexapeptide repeat family%3B KEGG: ljo:LJ0208 bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase gene gene186 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00187 WSWS_00188 WSWS_00188 prpS prpS 188010 188993 + Ribose-phosphate diphosphokinase Involved in the biosynthesis of ribose 1%2C5-bisphosphate. Catalyzes the transfer of pyrophosphoryl group from ATP to ribose- 5-phosphate to yield phosphoribosyl diphosphate (PRPP) and AMP%3B Belongs to the ribose-phosphate pyrophosphokinase family%3B KEGG: wko:WKK_02525 ribose-phosphate pyrophosphokinase gene gene187 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00188 WSWS_00189 WSWS_00189 WSWS_00189 189356 190069 + Glycerol uptake facilitator protein Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity)%3B Belongs to the MIP/aquaporin (TC 1. A. 8) family gene gene188 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00189 WSWS_00190 WSWS_00190 WSWS_00190 190148 190357 + hypothetical protein gene gene189 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00190 WSWS_00191 WSWS_00191 WSWS_00191 190532 190828 + 30S ribosomal protein S6 Binds together with S18 to 16S ribosomal RNA%3B Belongs to the ribosomal protein S6P family gene gene190 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00191 WSWS_00192 WSWS_00192 WSWS_00192 190886 191440 + Single-stranded DNA-binding protein Plays an important role in DNA replication%2C recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism%3B Contains 1 SSB domain gene gene191 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00192 WSWS_00193 WSWS_00193 WSWS_00193 191490 191732 + 30S ribosomal protein S18 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA%2C where it helps stabilize the platform of the 30S subunit%3B Belongs to the ribosomal protein S18P family gene gene192 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00193 WSWS_00194 WSWS_00194 WSWS_00194 191829 192830 - Putative ring-cleaving dioxygenase MhqE Putative ring-cleavage dioxygenase that may contribute to the degradation of aromatic compounds%3B Belongs to the extradiol ring-cleavage dioxygenase family gene gene193 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00194 WSWS_00195 WSWS_00195 WSWS_00195 192903 193217 - hypothetical protein gene gene194 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00195 WSWS_00196 WSWS_00196 WSWS_00196 193304 194299 + hypothetical protein gene gene195 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00196 WSWS_00197 WSWS_00197 WSWS_00197 194361 194963 - hypothetical protein gene gene196 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00197 WSWS_00198 WSWS_00198 WSWS_00198 195079 195921 + Energy-coupling factor transporter ATP-binding protein EcfA1 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates%3B Belongs to the ABC transporter superfamily. Energy- coupling factor EcfA family%3B Contains 1 ABC transporter domain gene gene197 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00198 WSWS_00199 WSWS_00199 WSWS_00199 195897 196760 + Energy-coupling factor transporter ATP-binding protein EcfA2 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates%3B Belongs to the ABC transporter superfamily. Energy- coupling factor EcfA family%3B Contains 1 ABC transporter domain gene gene198 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00199 WSWS_00200 WSWS_00200 WSWS_00200 196753 197553 + Energy-coupling factor transporter transmembrane protein EcfT Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates%3B Belongs to the energy-coupling factor EcfT family gene gene199 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00200 WSWS_00201 WSWS_00201 truA truA 197662 198411 + tRNA pseudouridine(38-40) synthase Formation of pseudouridine at positions 38%2C 39 and 40 in the anticodon stem and loop of transfer RNAs%3B Belongs to the tRNA pseudouridine synthase TruA family%3B KEGG: mno:Mnod_4747 tRNA pseudouridine38-40 synthase gene gene200 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00201 WSWS_00202 WSWS_00202 mot1 mot1 198424 201327 + Putative DNA helicase INO80 DNA helicase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair%3B Belongs to the SNF2/RAD54 helicase family%3B Contains 1 DBINO domain%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: cne:CNE04710 TATA-binding protein-associated factor%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene201 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00202 WSWS_00203 WSWS_00203 WSWS_00203 201480 201923 + 50S ribosomal protein L13 This protein is one of the early assembly proteins of the 50S ribosomal subunit%2C although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly%3B Belongs to the ribosomal protein L13P family gene gene202 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00203 WSWS_00204 WSWS_00204 WSWS_00204 201952 202344 + 30S ribosomal protein S9 Belongs to the ribosomal protein S9P family gene gene203 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00204 WSWS_00205 WSWS_00205 WSWS_00205 202471 203538 - hypothetical protein gene gene204 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00205 WSWS_00206 WSWS_00206 WSWS_00206 203640 203831 - hypothetical protein gene gene205 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00206 WSWS_00207 WSWS_00207 WSWS_00207 203828 205030 - hypothetical protein gene gene206 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00207 WSWS_00208 WSWS_00208 WSWS_00208 205271 205738 - hypothetical protein gene gene207 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00208 WSWS_00209 WSWS_00209 WSWS_00209 205741 206832 - hypothetical protein gene gene208 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00209 WSWS_00210 WSWS_00210 WSWS_00210 206832 207185 - hypothetical protein gene gene209 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00210 WSWS_00211 WSWS_00211 WSWS_00211 207368 208519 + hypothetical protein gene gene210 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00211 WSWS_00212 WSWS_00212 WSWS_00212 208866 213575 + hypothetical protein gene gene211 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00212 WSWS_00213 WSWS_00213 WSWS_00213 213637 214077 + hypothetical protein gene gene212 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00213 WSWS_00214 WSWS_00214 WSWS_00214 214064 214828 + hypothetical protein gene gene213 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00214 WSWS_00215 WSWS_00215 WSWS_00215 215340 216314 + hypothetical protein gene gene214 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00215 WSWS_00216 WSWS_00216 WSWS_00216 216748 217233 + hypothetical protein gene gene215 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00216 WSWS_00217 WSWS_00217 galA galA 217384 219600 + Alpha-galactosidase Alpha-galactosidase associated with the raffinose operon. Belongs to the glycosyl hydrolase 36 family%3B KEGG: sri:SELR_24320 alpha-galactosidase gene gene216 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00217 WSWS_00218 WSWS_00218 WSWS_00218 219665 220843 + hypothetical protein gene gene217 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00218 WSWS_00219 WSWS_00219 rfbA rfbA 221025 221897 + Glucose-1-phosphate thymidylyltransferase Catalyzes the formation of dTDP-glucose%2C from dTTP and glucose 1-phosphate in the novobiocin biosynthesis pathway%2C an aminocoumarin family antibiotic that targets bacterial DNA gyrases. Belongs to the glucose-1-phosphate thymidylyltransferase family%3B KEGG: eco:b3789 glucose-1-phosphate thymidylyltransferase gene gene218 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00219 WSWS_00220 WSWS_00220 rfbC rfbC 221903 222496 + dTDP-4-dehydrorhamnose 3%2C5-epimerase Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose%2C forming dTDP-6-deoxy-L-lyxo-4- hexulose%3B Belongs to the dTDP-4-dehydrorhamnose 3%2C5-epimerase family%3B KEGG: spy:SPy_0935 dTDP-4-dehydrorhamnose 3%2C5-epimerase gene gene219 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00220 WSWS_00221 WSWS_00221 rfbB rfbB 222511 223548 + dTDP-glucose 4%2C6-dehydratase Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation%2C dehydration and reduction%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily%3B KEGG: lla:L199221 dTDP-glucose 4%2C6-dehydratase gene gene220 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00221 WSWS_00222 WSWS_00222 rfbD rfbD 223588 224433 + dTDP-4-dehydrorhamnose reductase Belongs to the dTDP-4-dehydrorhamnose reductase family%3B KEGG: tol:TOL_2539 dTDP-4-dehydrorhamnose reductase gene gene221 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00222 WSWS_00223 WSWS_00223 WSWS_00223 224592 225641 + hypothetical protein gene gene222 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00223 WSWS_00224 WSWS_00224 WSWS_00224 226108 226935 + Pyridoxal phosphate phosphatase YigL Catalyzes the dephosphorylation of pyridoxal-phosphate (PLP) and sugar phosphate%3B Belongs to the HAD-like hydrolase superfamily. Cof family gene gene223 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00224 WSWS_00225 WSWS_00225 WSWS_00225 227097 227645 + hypothetical protein gene gene224 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00225 WSWS_00226 WSWS_00226 WSWS_00226 227786 229276 + Exopolyphosphatase KEGG: lrl:LC705_02610 exopolyphosphatase / guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase gene gene225 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00226 WSWS_00227 WSWS_00227 WSWS_00227 229276 231381 + Polyphosphate kinase Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)%3B Belongs to the polyphosphate kinase family%3B KEGG: mah:MEALZ_2833 polyphosphate kinase gene gene226 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00227 WSWS_00228 WSWS_00228 WSWS_00228 231401 232378 + Exopolyphosphatase Belongs to the GppA/Ppx family%3B KEGG: lme:LEUM_0244 exopolyphosphatase / guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase gene gene227 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00228 WSWS_00229 WSWS_00229 WSWS_00229 232468 232854 - hypothetical protein gene gene228 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00229 WSWS_00230 WSWS_00230 WSWS_00230 233327 234903 + 16S ribosomal RNA rRNA gene229 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00230 WSWS_00231 WSWS_00231 WSWS_00231 234984 235056 + tRNA-Ala tRNA gene230 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00231 WSWS_00232 WSWS_00232 WSWS_00232 235270 238186 + 23S ribosomal RNA rRNA gene231 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00232 WSWS_00233 WSWS_00233 WSWS_00233 238280 238396 + 5S ribosomal RNA rRNA gene232 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00233 WSWS_00234 WSWS_00234 yihV yihV 238575 239501 + Sulfofructose kinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: enc:ECL_05102 sulfofructose kinase gene gene233 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00234 WSWS_00235 WSWS_00235 WSWS_00235 239658 240929 + Pyrimidine nucleoside transport protein Belongs to the concentrative nucleoside transporter (CNT) (TC 2. A. 41) family gene gene234 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00235 WSWS_00236 WSWS_00236 iunH iunH 241031 241987 + Purine nucleosidase Hydrolyzes cytidine or uridine to ribose and cytosine or uracil%2C respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides%3B Belongs to the IUNH family. RihB subfamily%3B KEGG: psi:S70_07620 purine nucleosidase gene gene235 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00236 WSWS_00237 WSWS_00237 rihC rihC 242063 242977 + Pyrimidine-specific ribonucleoside hydrolase RihA Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil%2C respectively%3B Belongs to the IUNH family. RihA subfamily%3B KEGG: eco:b0030 non-specific riboncleoside hydrolase%3B Glycosylases gene gene236 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00237 WSWS_00238 WSWS_00238 WSWS_00238 243056 243403 - hypothetical protein gene gene237 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00238 WSWS_00239 WSWS_00239 WSWS_00239 243519 243950 + hypothetical protein gene gene238 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00239 WSWS_00240 WSWS_00240 WSWS_00240 244066 246918 + UvrABC system protein The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB%2C the UvrA molecules dissociate%3B Belongs to the ABC transporter superfamily. UvrA family%3B Contains 2 ABC transporter domains gene gene239 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00240 WSWS_00241 WSWS_00241 WSWS_00241 247014 247136 + hypothetical protein gene gene240 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00241 WSWS_00242 WSWS_00242 birA birA 247390 248139 + Biotin--[acetyl-CoA-carboxylase] ligase KEGG: bfi:CIY_33270 BirA family transcriptional regulator%2C biotin operon repressor / biotin-(acetyl-CoA-carboxylase) ligase gene gene241 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00242 WSWS_00243 WSWS_00243 WSWS_00243 248136 248663 + Biotin transporter BioY2 Probably a biotin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane%2C not extracytoplasmic soluble proteins. Belongs to the BioY family gene gene242 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00243 WSWS_00244 WSWS_00244 WSWS_00244 248821 249378 + Guanylate kinase Essential for recycling GMP and indirectly%2C cGMP%3B Belongs to the guanylate kinase family%3B Contains 1 guanylate kinase-like domain%3B KEGG: lsn:LSA_03170 guanylate kinase gene gene243 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00244 WSWS_00245 WSWS_00245 WSWS_00245 249406 249816 + Chitinase KEGG: lbr:LVIS_1777 chitinase gene gene244 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00245 WSWS_00246 WSWS_00246 WSWS_00246 249816 250613 + hypothetical protein gene gene245 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00246 WSWS_00247 WSWS_00247 WSWS_00247 250928 251662 + Polar-amino-acid-transporting ATPase Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain%3B KEGG: sty:STY1436 polar amino acid transport system ATP-binding protein gene gene246 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00247 WSWS_00248 WSWS_00248 WSWS_00248 251711 252547 + ABC transporter glutamine-binding protein GlnH Part of the ABC transporter complex GlnHMPQ involved in glutamine transport%3B Belongs to the bacterial solute-binding protein 3 family gene gene247 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00248 WSWS_00249 WSWS_00249 WSWS_00249 252547 253191 + putative glutamine ABC transporter permease protein GlnM Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family%3B Contains 1 ABC transmembrane type-1 domain gene gene248 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00249 WSWS_00250 WSWS_00250 WSWS_00250 253193 253849 + putative glutamine ABC transporter permease protein GlnM Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family%3B Contains 1 ABC transmembrane type-1 domain gene gene249 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00250 WSWS_00251 WSWS_00251 WSWS_00251 254167 255807 + Glutathione-binding protein GsiB Part of the ABC transporter complex GsiABCD involved in glutathione import%3B Belongs to the bacterial solute-binding protein 5 family gene gene250 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00251 WSWS_00252 WSWS_00252 WSWS_00252 256292 257209 + Dipeptide transport system permease protein DppB Part of the binding-protein-dependent transport system for dipeptide%3B probably responsible for the translocation of the substrate across the membrane. Is expressed to facilitate adaptation to nutrient deficiency conditions. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene251 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00252 WSWS_00253 WSWS_00253 WSWS_00253 257226 258245 + Dipeptide transport system permease protein DppC Part of the binding-protein-dependent transport system for dipeptide%3B probably responsible for the translocation of the substrate across the membrane. Is expressed to facilitate adaptation to nutrient deficiency conditions%2C which also induce sporulation. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene252 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00253 WSWS_00254 WSWS_00254 WSWS_00254 258267 259370 + Oligopeptide transport ATP-binding protein AmiF Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene253 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00254 WSWS_00255 WSWS_00255 WSWS_00255 259370 260317 + Oligopeptide transport ATP-binding protein OppF Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene254 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00255 WSWS_00256 WSWS_00256 WSWS_00256 260610 261563 + Ammonium/H(+) antiporter subunit AmhT Ammonium/proton antiporter that mediates the efflux of ammonium ions. Can also transport potassium or rubidium%2C but not sodium or lithium%3B Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2. A. 37) family gene gene255 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00256 WSWS_00257 WSWS_00257 WSWS_00257 261645 262259 + hypothetical protein gene gene256 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00257 WSWS_00258 WSWS_00258 WSWS_00258 262447 264462 + uncharacterized protein Contains 1 GGDEF domain gene gene257 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00258 WSWS_00259 WSWS_00259 WSWS_00259 264496 264948 + 50S ribosomal protein L9 Binds to the 23S rRNA%3B Belongs to the ribosomal protein L9P family gene gene258 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00259 WSWS_00260 WSWS_00260 polC polC 265121 269548 + DNA-directed DNA polymerase Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity%3B Belongs to the DNA polymerase type-C family. PolC subfamily%3B Contains 1 exonuclease domain%3B KEGG: wko:WKK_04840 DNA polymerase III subunit alpha%2C Gram-positive type gene gene259 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00260 WSWS_00261 WSWS_00261 WSWS_00261 270060 271636 + 16S ribosomal RNA rRNA gene260 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00261 WSWS_00262 WSWS_00262 WSWS_00262 271717 271789 + tRNA-Ala tRNA gene261 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00262 WSWS_00263 WSWS_00263 WSWS_00263 272003 274919 + 23S ribosomal RNA rRNA gene262 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00263 WSWS_00264 WSWS_00264 WSWS_00264 275013 275129 + 5S ribosomal RNA rRNA gene263 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00264 WSWS_00265 WSWS_00265 WSWS_00265 275244 275675 - hypothetical protein gene gene264 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00265 WSWS_00266 WSWS_00266 WSWS_00266 275779 277038 + ComF operon protein Involved in transformation (competence for DNA uptake). Required for DNA uptake but not for binding. May provide the driving force for transport of DNA through an aqueous channel. Belongs to the helicase family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain gene gene265 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00266 WSWS_00267 WSWS_00267 WSWS_00267 277043 277714 + hypothetical protein gene gene266 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00267 WSWS_00268 WSWS_00268 WSWS_00268 277893 278450 + Ribosome-associated factor Belongs to the ribosomal protein S30Ae family gene gene267 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00268 WSWS_00269 WSWS_00269 WSWS_00269 278559 279002 + hypothetical protein gene gene268 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00269 WSWS_00270 WSWS_00270 WSWS_00270 279006 281201 + uncharacterized protein Contains 1 S1 motif domain gene gene269 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00270 WSWS_00271 WSWS_00271 WSWS_00271 281408 281947 + hypothetical protein gene gene270 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00271 WSWS_00272 WSWS_00272 WSWS_00272 281995 282291 + hypothetical protein gene gene271 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00272 WSWS_00273 WSWS_00273 WSWS_00273 282450 283553 + Spermidine/putrescine import ATP-binding protein PotA Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene272 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00273 WSWS_00274 WSWS_00274 WSWS_00274 283540 284352 + Spermidine/putrescine transport system permease protein PotB like protein Required for the activity of the bacterial transport system of putrescine and spermidine%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene273 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00274 WSWS_00275 WSWS_00275 WSWS_00275 284354 285178 + Spermidine/putrescine transport system permease protein Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene274 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00275 WSWS_00276 WSWS_00276 WSWS_00276 285175 286266 + Spermidine-binding periplasmic protein SpuE Spermidine-binding protein probably required for its uptake into cells. Binds spermidine with high affinity (KD%3D14. 3 nM). Does not bind putrescine%2C cadaverine or spermine. Spermidine binding induces large inter-domain conformational changes. Implicated in induction of type 3 secretion systems (T3SS)%2C which play a role in virulence%3B Belongs to the bacterial solute-binding protein PotD/PotF family gene gene275 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00276 WSWS_00277 WSWS_00277 ppiA ppiA 286397 287239 + Peptidylprolyl isomerase PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family%3B Contains 1 PPIase cyclophilin-type domain%3B KEGG: wko:WKK_05155 peptidyl-prolyl cis-trans isomerase A (cyclophilin A) gene gene276 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00277 WSWS_00278 WSWS_00278 WSWS_00278 287381 287659 + 10 kDa chaperonin Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter%3B Belongs to the GroES chaperonin family gene gene277 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00278 WSWS_00279 WSWS_00279 WSWS_00279 287707 289326 + 60 kDa chaperonin Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions%3B Belongs to the chaperonin (HSP60) family gene gene278 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00279 WSWS_00280 WSWS_00280 WSWS_00280 289647 289847 + Cold shock protein Contains 1 CSD (cold-shock) domain gene gene279 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00280 WSWS_00281 WSWS_00281 WSWS_00281 290065 291099 + UPF0118 membrane protein YdbI Belongs to the UPF0118 (PerM) family gene gene280 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00281 WSWS_00282 WSWS_00282 WSWS_00282 291251 292627 + Nicotinamide riboside transporter High-affinity pH-dependent nicotinamide riboside transporter which also transports thiamine with low affinity. Involved in 5-fluorocytosine sensitivity%3B Belongs to the purine-cytosine permease (2. A. 39) family gene gene281 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00282 WSWS_00283 WSWS_00283 WSWS_00283 292779 294239 + Lysine/arginine/ornithine-binding periplasmic protein Part of an ABC transporter involved in lysine%2C arginine and ornithine transport. Stimulates ATPase activity of HisP (By similarity)%3B Belongs to the bacterial solute-binding protein 3 family gene gene282 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00283 WSWS_00284 WSWS_00284 WSWS_00284 294239 294976 + putative ATP-dependent transporter ycf16 Belongs to the ABC transporter superfamily. Ycf16 family%3B Contains 1 ABC transporter domain gene gene283 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00284 WSWS_00285 WSWS_00285 srtA srtA 295081 296046 - Sortase A KEGG: lme:LEUM_0714 sortase A gene gene284 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00285 WSWS_00286 WSWS_00286 WSWS_00286 296056 296592 - hypothetical protein gene gene285 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00286 WSWS_00287 WSWS_00287 WSWS_00287 296830 297810 + Phosphate acetyltransferase Belongs to the phosphate acetyltransferase and butyryltransferase family%3B KEGG: pmic:NW74_00275 phosphate acetyltransferase gene gene286 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00287 WSWS_00288 WSWS_00288 dnaB dnaB 297995 299407 + DNA helicase Participates in initiation and elongation during chromosome replicatio%3B it exhibits DNA-dependent ATPase activity%3B Belongs to the helicase family. DnaB subfamily%3B Contains 1 DOD-type homing endonuclease domain%3B Contains 1 SF4 helicase domain%3B KEGG: lme:LEUM_1965 replicative DNA helicase gene gene287 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00288 WSWS_00289 WSWS_00289 WSWS_00289 299521 300711 + putative MFS-type transporter YttB Belongs to the major facilitator superfamily gene gene288 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00289 WSWS_00290 WSWS_00290 WSWS_00290 300730 301266 + hypothetical protein gene gene289 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00290 WSWS_00291 WSWS_00291 WSWS_00291 301343 302476 + hypothetical protein gene gene290 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00291 WSWS_00292 WSWS_00292 WSWS_00292 302466 303635 + hypothetical protein gene gene291 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00292 WSWS_00293 WSWS_00293 WSWS_00293 303632 303931 + hypothetical protein gene gene292 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00293 WSWS_00294 WSWS_00294 ispE ispE 304015 304872 + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol%3B Belongs to the GHMP kinase family. IspE subfamily%3B KEGG: wko:WKK_04765 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase gene gene293 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00294 WSWS_00295 WSWS_00295 WSWS_00295 304957 305973 + UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase Involved in the synthesis of the bacterial cell wall. Catalyzes the addition of alanine into the interchain peptide bridge of peptidoglycan precursor using aminoacyl-tRNA(Ala) as amino acid donor. This alanine is added to the epsilon-amino group of the L-lysine of the peptidoglycan UDP-N-acetyl-alpha-D- muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine%2C in a ribosome-independent mechanism (PubMed:11083873%2C PubMed:4248527%2C PubMed:12679335%2C PubMed:15901708%2C PubMed:23744707). Specific for UDP-N-acetyl-muramoyl-pentapeptide. Has no activity toward UDP-N- acetyl-muramoyl-tetrapeptide or UDP-N-acetyl-muramoyl-tripeptide (PubMed:15901708). Also acts on L-seryl-tRNA(Ser) (PubMed:4248527)%3B Belongs to the FemABX family gene gene294 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00295 WSWS_00296 WSWS_00296 nagA nagA 306099 307268 + N-acetylglucosamine-6-phosphate deacetylase Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N- acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate%3B Belongs to the NagA family%3B KEGG: wce:WS08_0111 N-acetylglucosamine-6-phosphate deacetylase gene gene295 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00296 WSWS_00297 WSWS_00297 WSWS_00297 307278 307979 + HTH-type transcriptional regulator FrlR May regulate the transcription of the frlABCD operon%3B Contains 1 HTH gntR-type DNA-binding domain gene gene296 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00297 WSWS_00298 WSWS_00298 WSWS_00298 308192 309883 + D-lactate dehydrogenase First component of the membrane-bound D-lactate oxidase%2C which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids. Contains 1 FAD-binding PCMH-type domain%3B KEGG: hso:HS_0784 D-lactate dehydrogenase gene gene297 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00298 WSWS_00299 WSWS_00299 WSWS_00299 310115 310726 + 30S ribosomal protein S4 One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit%3B With S5 and S12 plays an important role in translational accuracy%3B Belongs to the ribosomal protein S4P family%3B Contains 1 S4 RNA-binding domain gene gene298 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00299 WSWS_00300 WSWS_00300 WSWS_00300 311021 312730 + Septation ring formation regulator EzrA Negative regulator of FtsZ ring formatio%3B modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization%3B Belongs to the EzrA family gene gene299 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00300 WSWS_00301 WSWS_00301 WSWS_00301 312880 315165 + DNA helicase Catalyzes the unwinding of duplex DNA in the 3' to 5' directio%3B this reaction is dependent on the hydrolysis of ATP%3B Belongs to the helicase family. UvrD subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B KEGG: wko:WKK_01815 DNA helicase II / ATP-dependent DNA helicase PcrA gene gene300 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00301 WSWS_00302 WSWS_00302 coaA coaA 315307 316254 + Pantothenate kinase Belongs to the prokaryotic pantothenate kinase family%3B KEGG: wko:WKK_01810 type I pantothenate kinase gene gene301 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00302 WSWS_00303 WSWS_00303 WSWS_00303 316620 317381 + Mucin-21 gene gene302 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00303 WSWS_00304 WSWS_00304 WSWS_00304 317489 317944 + hypothetical protein gene gene303 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00304 WSWS_00305 WSWS_00305 WSWS_00305 317958 319244 + putative AAA domain-containing protein YrvN Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily gene gene304 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00305 WSWS_00306 WSWS_00306 WSWS_00306 319581 319859 + hypothetical protein gene gene305 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00306 WSWS_00307 WSWS_00307 WSWS_00307 320044 320490 + Putative universal stress protein Belongs to the universal stress protein A family gene gene306 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00307 WSWS_00308 WSWS_00308 WSWS_00308 320668 321447 + hypothetical protein gene gene307 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00308 WSWS_00309 WSWS_00309 WSWS_00309 321602 322390 - hypothetical protein gene gene308 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00309 WSWS_00310 WSWS_00310 WSWS_00310 322470 323120 - UPF0073 inner membrane protein YqfA Belongs to the UPF0073 (Hly-III) family gene gene309 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00310 WSWS_00311 WSWS_00311 WSWS_00311 323305 324048 + Adapter protein MecA Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis%3B Belongs to the MecA family gene gene310 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00311 WSWS_00312 WSWS_00312 WSWS_00312 324182 325183 + uncharacterized protein gene gene311 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00312 WSWS_00313 WSWS_00313 WSWS_00313 325185 326087 + uncharacterized protein gene gene312 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00313 WSWS_00314 WSWS_00314 WSWS_00314 326080 326850 + Spermidine/putrescine import ATP-binding protein PotA Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene313 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00314 WSWS_00315 WSWS_00315 WSWS_00315 327006 327977 + putative HTH-type transcriptional regulator Contains 1 HTH lacI-type DNA-binding domain gene gene314 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00315 WSWS_00316 WSWS_00316 rbsK rbsK 328175 329101 + Ribokinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: vsp:VS_II0944 ribokinase gene gene315 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00316 WSWS_00317 WSWS_00317 WSWS_00317 329101 329790 + Ribose-5-phosphate isomerase Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate%3B Belongs to the ribose 5-phosphate isomerase family%3B KEGG: lcn:C270_05125 ribose 5-phosphate isomerase A gene gene316 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00317 WSWS_00318 WSWS_00318 aarS aarS 330080 332725 + Alanine--tRNA ligase Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: cyq:Q91_0861 alanyl-tRNA synthetase gene gene317 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00318 WSWS_00319 WSWS_00319 ruvX ruvX 332848 333099 + UPF0297 protein Belongs to the UPF0297 family%3B KEGG: snu:SPNA45_01835 putative holliday junction resolvase%3B Acting on ester bonds gene gene318 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00319 WSWS_00320 WSWS_00320 WSWS_00320 333096 333557 + Putative pre-16S rRNA nuclease Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA%3B Belongs to the YqgF nuclease family%3B KEGG: dao:Desac_2916 putative holliday junction resolvase%3B Acting on ester bonds gene gene319 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00320 WSWS_00321 WSWS_00321 WSWS_00321 333665 334075 + Cell wall teichoic acid glycosylation protein Involved in the decoration of cell wall teichoic acid with galactose and glucose%3B Belongs to the GtrA family gene gene320 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00321 WSWS_00322 WSWS_00322 WSWS_00322 334185 334463 + UPF0473 protein Belongs to the UPF0473 family gene gene321 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00322 WSWS_00323 WSWS_00323 WSWS_00323 334472 334759 + UPF0473 protein Belongs to the UPF0473 family gene gene322 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00323 WSWS_00324 WSWS_00324 dagK dagK 334865 335803 + Diacylglycerol kinase (ATP) Catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid. Is a key enzyme involved in the production of lipoteichoic acid by reintroducing DAG formed from the breakdown of membrane phospholipids into the phosphatidylglycerol biosynthetic pathway (By similarity)%3B Belongs to the diacylglycerol/lipid kinase family%3B Contains 1 DAGKc domain%3B KEGG: bsus:Q433_03805 diacylglycerol kinase (ATP) gene gene323 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00324 WSWS_00325 WSWS_00325 WSWS_00325 335931 336422 + hypothetical protein gene gene324 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00325 WSWS_00326 WSWS_00326 WSWS_00326 336470 337777 - Putative permease Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2. A. 1. 40) subfamily gene gene325 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00326 WSWS_00327 WSWS_00327 purA purA 338052 339350 + Adenylosuccinate synthase Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP%3B Belongs to the adenylosuccinate synthetase family%3B KEGG: bba:Bd1460 adenylosuccinate synthase gene gene326 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00327 WSWS_00328 WSWS_00328 hprT hprT 339370 339906 + Hypoxanthine phosphoribosyltransferase Belongs to the purine/pyrimidine phosphoribosyltransferase family%3B KEGG: wce:WS08_0117 hypoxanthine phosphoribosyltransferase gene gene327 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00328 WSWS_00329 WSWS_00329 WSWS_00329 339955 340728 - hypothetical protein gene gene328 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00329 WSWS_00330 WSWS_00330 WSWS_00330 340867 341694 + 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YbjI Catalyzes the dephosphorylation of 5-amino-6-(5-phospho- D-ribitylamino)uracil%2C and thus could be involved in the riboflavin biosynthesis pathway (PubMed:24123841). Is also able to dephosphorylate flavin mononucleotide (FMN)%2C erythrose 4-phosphate and other phosphoric acid esters (PubMed:15808744%2C PubMed:16990279%2C PubMed:24123841)%3B Belongs to the HAD-like hydrolase superfamily. Cof family gene gene329 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00330 WSWS_00331 WSWS_00331 uppS uppS 341765 342550 + Ditrans%2Cpolycis-undecaprenyl-diphosphate synthase ((2E%2C6E)-farnesyl-diphosphate specific) Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids%3B Belongs to the UPP synthase family%3B KEGG: dai:Desaci_3555 undecaprenyl diphosphate synthase gene gene330 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00331 WSWS_00332 WSWS_00332 cds1 cds1 342585 343385 + Phosphatidate cytidylyltransferase Belongs to the CDS family%3B KEGG: lmo:lmo1316 phosphatidate cytidylyltransferase gene gene331 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00332 WSWS_00333 WSWS_00333 rseP rseP 343560 344819 + Putative zinc metalloprotease Belongs to the peptidase M50B family%3B Contains 1 PDZ (DHR) domain%3B KEGG: mcl:MCCL_0847 regulator of sigma E protease%3B Metalloendopeptidases gene gene332 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00333 WSWS_00334 WSWS_00334 WSWS_00334 344889 344961 + tRNA-Arg tRNA gene333 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00334 WSWS_00335 WSWS_00335 WSWS_00335 344994 347057 + putative cell division protein YtgP May play a role in cell division%2C although it is not essential for growth%3B Belongs to the polysaccharide synthase family gene gene334 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00335 WSWS_00336 WSWS_00336 WSWS_00336 347141 347665 + hypothetical protein gene gene335 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00336 WSWS_00337 WSWS_00337 parS parS 347745 349457 + Proline--tRNA ligase Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine%2C to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS%3B Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily%3B KEGG: bck:BCO26_1170 prolyl-tRNA synthetase gene gene336 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00337 WSWS_00338 WSWS_00338 rnt1 rnt1 349624 350319 + Ribonuclease III Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs%2C and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism%3B Contains 1 DRBM (double-stranded RNA-binding) domain%3B Contains 1 RNase III domain%3B KEGG: wko:WKK_00600 ribonuclease III gene gene337 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00338 WSWS_00339 WSWS_00339 WSWS_00339 350337 353885 + Chromosome partition protein Smc Required for chromosome condensation and partitioning%3B Belongs to the SMC family gene gene338 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00339 WSWS_00340 WSWS_00340 WSWS_00340 353899 355083 + Signal recognition particle receptor FtsY Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)%3B Belongs to the GTP-binding SRP family. FtsY subfamily gene gene339 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00340 WSWS_00341 WSWS_00341 WSWS_00341 355085 355426 + UPF0122 protein Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein%3B Belongs to the UPF0122 family gene gene340 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00341 WSWS_00342 WSWS_00342 WSWS_00342 355439 356923 + Signal recognition particle protein Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane%2C the hydrolysis of GTP by both Ffh and FtsY%2C and the dissociation of the SRP-FtsY complex into the individual components (Probable)%3B Belongs to the GTP-binding SRP family. SRP54 subfamily gene gene341 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00342 WSWS_00343 WSWS_00343 WSWS_00343 357000 357734 - Putative NrdI-like protein Belongs to the NrdI family gene gene342 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00343 WSWS_00344 WSWS_00344 nrdA nrdA 358102 360273 + Ribonucleoside-diphosphate reductase Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)%3B Belongs to the ribonucleoside diphosphate reductase large chain family%3B KEGG: wko:WKK_01170 ribonucleoside-diphosphate reductase alpha chain gene gene343 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00344 WSWS_00345 WSWS_00345 nrdB nrdB 360398 361363 + Ribonucleoside-diphosphate reductase Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)%3B Belongs to the ribonucleoside diphosphate reductase small chain family%3B KEGG: str:Sterm_2764 ribonucleoside-diphosphate reductase beta chain gene gene344 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00345 WSWS_00346 WSWS_00346 WSWS_00346 361563 362174 + Pantothenate transporter PanT Probable pantothenate-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane%2C not extracytoplasmic soluble proteins and transport it into cells. Upon coexpression with its energy-coupling factor (ECF) ABC- transporter complex EcfA1A2T in E. coli allows pantothenate uptak%3B uptake requires both PanT and EcfA1A2T gene gene345 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00346 WSWS_00347 WSWS_00347 thiM thiM 362462 363241 + Hydroxyethylthiazole kinase Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)%3B Belongs to the Thz kinase family%3B KEGG: mfo:Metfor_0959 hydroxyethylthiazole kinase gene gene346 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00347 WSWS_00348 WSWS_00348 WSWS_00348 363238 364035 + Hydroxymethylpyrimidine kinase Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP%2C and of HMP to HMP-P%3B Belongs to the ThiD family%3B KEGG: van:VAA_00499 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase gene gene347 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00348 WSWS_00349 WSWS_00349 thiE thiE 364037 364699 + Thiamine phosphate synthase Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)%3B Belongs to the thiamine-phosphate synthase family%3B KEGG: wko:WKK_02275 thiamine-phosphate pyrophosphorylase gene gene348 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00349 WSWS_00350 WSWS_00350 tenA tenA 364683 365282 + Aminopyrimidine aminohydrolase KEGG: wce:WS08_0578 thiaminase (transcriptional activator TenA) gene gene349 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00350 WSWS_00351 WSWS_00351 WSWS_00351 365425 367389 + DNA mismatch repair protein MutL This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker'%2C a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex%3B Belongs to the DNA mismatch repair MutL/HexB family gene gene350 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00351 WSWS_00352 WSWS_00352 WSWS_00352 367449 367907 + hypothetical protein gene gene351 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00352 WSWS_00353 WSWS_00353 tarS tarS 368320 370263 + Threonine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: shv:AAT16_08270 threonyl-tRNA synthetase gene gene352 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00353 WSWS_00354 WSWS_00354 WSWS_00354 370648 372228 + hypothetical protein gene gene353 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00354 WSWS_00355 WSWS_00355 purB purB 372316 373656 + Adenylosuccinate lyase Influences the affinity of glutamyl--tRNA ligase for its substrates and increases its thermostability. Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily%3B KEGG: plv:ERIC2_c08220 adenylosuccinate lyase gene gene354 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00355 WSWS_00356 WSWS_00356 fabZ fabZ 373910 374350 + 3-hydroxyacyl-[acyl-carrier-protein] dehydratase Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs%3B Belongs to the thioester dehydratase family. FabZ subfamily%3B KEGG: lme:LEUM_0307 3-hydroxyacyl-(acyl-carrier-protein) dehydratase gene gene355 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00356 WSWS_00357 WSWS_00357 WSWS_00357 374358 374837 + hypothetical protein gene gene356 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00357 WSWS_00358 WSWS_00358 fabH fabH 374874 375842 + Beta-ketoacyl-[acyl-carrier-protein] synthase III Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids%3B Belongs to the FabH family%3B KEGG: cbn:CbC4_0045 3-oxoacyl-(acyl-carrier-protein) synthase III gene gene357 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00358 WSWS_00359 WSWS_00359 WSWS_00359 375907 376146 + Acyl carrier protein Carrier of the growing fatty acid chain in fatty acid biosynthesis%3B Contains 1 acyl carrier domain gene gene358 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00359 WSWS_00360 WSWS_00360 fabK fabK 376200 377162 + Enoyl-[acyl-carrier-protein] reductase (NADH) Catalyzes the oxidation of alkyl nitronates to produce the corresponding carbonyl compounds and nitrites%3B Belongs to the nitronate monooxygenase family%3B KEGG: lci:LCK_00303 enoyl-(acyl-carrier protein) reductase II gene gene359 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00360 WSWS_00361 WSWS_00361 fabD fabD 377172 378101 + [Acyl-carrier-protein] S-malonyltransferase Belongs to the FabD family%3B KEGG: lsa:LSA0815 (acyl-carrier-protein) S-malonyltransferase gene gene360 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00361 WSWS_00362 WSWS_00362 idnO idnO 378103 378828 + Gluconate 5-dehydrogenase Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3- beta%2C17-beta-diol (in vitro) (By similarity)%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: vap:Vapar_3338 gluconate 5-dehydrogenase gene gene361 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00362 WSWS_00363 WSWS_00363 fabF fabF 378995 380230 + Beta-ketoacyl-[acyl-carrier-protein] synthase II Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP%3B Belongs to the beta-ketoacyl-ACP synthases family%3B KEGG: cps:CPS_2299 3-oxoacyl-(acyl-carrier-protein) synthase II gene gene362 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00363 WSWS_00364 WSWS_00364 WSWS_00364 380230 380697 + Biotin carboxyl carrier protein of acetyl-CoA carboxylase This protein is a component of the acetyl coenzyme A carboxylase comple%3B first%2C biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA%3B Contains 1 biotinyl-binding domain gene gene363 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00364 WSWS_00365 WSWS_00365 WSWS_00365 380790 381275 + 3-hydroxyacyl-[acyl-carrier-protein] dehydratase Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs%3B Belongs to the thioester dehydratase family. FabZ subfamily%3B KEGG: cbu:CBU_0614 3-hydroxyacyl-(acyl-carrier-protein) dehydratase gene gene364 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00365 WSWS_00366 WSWS_00366 accC accC 381276 382679 + Acetyl-CoA carboxylase Contains 1 ATP-grasp domain%3B Contains 1 biotin carboxylation domain%3B KEGG: wgl:WIGMOR_0138 acetyl-CoA carboxylase%2C biotin carboxylase subunit%3B overlaps another CDS with the same product name gene gene365 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00366 WSWS_00367 WSWS_00367 accD accD 382663 383505 + Acetyl-CoA carboxylase Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA%3B Belongs to the AccD/PCCB family%3B KEGG: lme:LEUM_0318 acetyl-CoA carboxylase carboxyl transferase subunit beta%3B overlaps another CDS with the same product name gene gene366 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00367 WSWS_00368 WSWS_00368 accA accA 383505 384287 + Acetyl-CoA carboxylase Component of the acetyl coenzyme A carboxylase (ACC) complex. First%2C biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA%3B Belongs to the AccA family%3B KEGG: lme:LEUM_0319 acetyl-CoA carboxylase carboxyl transferase subunit alpha%3B overlaps another CDS with the same product name gene gene367 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00368 WSWS_00369 WSWS_00369 WSWS_00369 384666 386242 + 16S ribosomal RNA rRNA gene368 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00369 WSWS_00370 WSWS_00370 WSWS_00370 386323 386395 + tRNA-Ala tRNA gene369 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00370 WSWS_00371 WSWS_00371 WSWS_00371 386609 389525 + 23S ribosomal RNA rRNA gene370 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00371 WSWS_00372 WSWS_00372 WSWS_00372 389619 389735 + 5S ribosomal RNA rRNA gene371 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00372 WSWS_00373 WSWS_00373 WSWS_00373 389742 389814 + tRNA-Val tRNA gene372 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00373 WSWS_00374 WSWS_00374 WSWS_00374 389836 389919 + tRNA-Leu tRNA gene373 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00374 WSWS_00375 WSWS_00375 WSWS_00375 389971 390044 + tRNA-Pro tRNA gene374 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00375 WSWS_00376 WSWS_00376 WSWS_00376 390165 390473 + hypothetical protein gene gene375 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00376 WSWS_00377 WSWS_00377 WSWS_00377 390579 393335 - hypothetical protein gene gene376 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00377 WSWS_00378 WSWS_00378 manX manX 393830 394792 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannose transport (By similarity)%3B Contains 1 PTS EIIA type-4 domain%3B Contains 1 PTS EIIB type-4 domain%3B KEGG: wko:WKK_01835 PTS system%2C mannose-specific IIA component gene gene377 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00378 WSWS_00379 WSWS_00379 WSWS_00379 394853 395662 + Fructose permease IIC component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in fructose transport. Contains 1 PTS EIIC type-4 domain gene gene378 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00379 WSWS_00380 WSWS_00380 WSWS_00380 395679 396593 + N-acetylgalactosamine permease IID component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport. Contains 1 PTS EIID domain gene gene379 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00380 WSWS_00381 WSWS_00381 WSWS_00381 396668 397054 + hypothetical protein gene gene380 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00381 WSWS_00382 WSWS_00382 WSWS_00382 397138 397935 + Regulatory protein RecX Modulates RecA activity%3B Belongs to the RecX family gene gene381 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00382 WSWS_00383 WSWS_00383 WSWS_00383 398050 398601 + UPF0374 protein Belongs to the UPF0374 family gene gene382 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00383 WSWS_00384 WSWS_00384 WSWS_00384 398754 399620 + hypothetical protein gene gene383 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00384 WSWS_00385 WSWS_00385 WSWS_00385 399913 401673 + Multidrug resistance-like ATP-binding protein Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3. A. 1. 117) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene384 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00385 WSWS_00386 WSWS_00386 WSWS_00386 401666 403456 + putative multidrug resistance ABC transporter ATP-binding/permease protein YheH Involved in the transport of four structurally unrelated drugs%2C including doxorubicin and mitoxantrone. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene385 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00386 WSWS_00387 WSWS_00387 WSWS_00387 403671 404888 + Monocarboxylate transporter Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity)%3B Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2. A. 1. 13) family gene gene386 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00387 WSWS_00388 WSWS_00388 pepF pepF 404942 406744 - Group B oligopeptidase PepB Also hydrolyzes the synthetic collagen-like substrate N-(3-[2- furyl]acryloyl)-Leu-Gly-Pro-Ala (FALGPA). Belongs to the peptidase M3B family%3B KEGG: lme:LEUM_0442 oligoendopeptidase F%3B Metalloendopeptidases gene gene387 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00388 WSWS_00389 WSWS_00389 pepQ pepQ 406891 407991 - Xaa-Pro dipeptidase Belongs to the peptidase M24B family%3B KEGG: gtn:GTNG_2676 Xaa-Pro dipeptidase gene gene388 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00389 WSWS_00390 WSWS_00390 WSWS_00390 408273 409274 + Catabolite control protein Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA)%2C which ensures optimal energy usage under diverse conditions%3B Contains 1 HTH lacI-type DNA-binding domain gene gene389 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00390 WSWS_00391 WSWS_00391 purE purE 409659 410147 + 5-(carboxyamino)imidazole ribonucleotide mutase Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)%3B Belongs to the AIR carboxylase family. Class I subfamily%3B KEGG: amc:MADE_1002880 5-(carboxyamino)imidazole ribonucleotide mutase gene gene390 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00391 WSWS_00392 WSWS_00392 purK purK 410140 411270 + 5-(carboxyamino)imidazole ribonucleotide synthase Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)%3B Belongs to the PurK/PurT family%3B Contains 1 ATP-grasp domain%3B KEGG: jeo:JMA_11180 5-(carboxyamino)imidazole ribonucleotide synthase gene gene391 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00392 WSWS_00393 WSWS_00393 purC purC 411257 411985 + Phosphoribosylaminoimidazolesuccinocarboxamide synthase Belongs to the SAICAR synthetase family%3B KEGG: prw:PsycPRwf_2126 phosphoribosylaminoimidazole-succinocarboxamide synthase gene gene392 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00393 WSWS_00394 WSWS_00394 purL purL 411995 412246 + Phosphoribosylformylglycinamidine synthase Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL%3B Belongs to the PurS family%3B KEGG: lbh:Lbuc_0369 phosphoribosylformylglycinamidine synthase gene gene393 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00394 WSWS_00395 WSWS_00395 WSWS_00395 412248 412931 + Phosphoribosylformylglycinamidine synthase Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: wce:WS08_0682 phosphoribosylformylglycinamidine synthase gene gene394 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00395 WSWS_00396 WSWS_00396 WSWS_00396 412939 415173 + Phosphoribosylformylglycinamidine synthase Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL%3B Belongs to the FGAMS family%3B KEGG: pjd:Pjdr2_0866 phosphoribosylformylglycinamidine synthase gene gene395 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00396 WSWS_00397 WSWS_00397 purF purF 415155 416687 + Amidophosphoribosyltransferase Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine%3B In the C-terminal sectio%3B belongs to the purine/pyrimidine phosphoribosyltransferase family%3B Contains 1 glutamine amidotransferase type-2 domain%3B KEGG: sme:SMc00554 amidophosphoribosyltransferase gene gene396 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00397 WSWS_00398 WSWS_00398 purM purM 416687 417718 + Phosphoribosylformylglycinamidine cyclo-ligase Belongs to the AIR synthase family%3B KEGG: wce:WS08_0679 phosphoribosylformylglycinamidine cyclo-ligase gene gene397 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00398 WSWS_00399 WSWS_00399 purN purN 417709 418293 + Phosphoribosylglycinamide formyltransferase Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR)%2C producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate%3B Belongs to the GART family%3B KEGG: axl:AXY_04350 phosphoribosylglycinamide formyltransferase 1 gene gene398 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00399 WSWS_00400 WSWS_00400 purH purH 418293 419822 + Phosphoribosylaminoimidazolecarboxamide formyltransferase Belongs to the PurH family%3B KEGG: eco:b4006 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase gene gene399 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00400 WSWS_00401 WSWS_00401 purD purD 419970 421238 + Phosphoribosylamine--glycine ligase Belongs to the GARS family%3B Contains 1 ATP-grasp domain%3B KEGG: bto:WQG_11090 phosphoribosylamine--glycine ligase gene gene400 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00401 WSWS_00402 WSWS_00402 WSWS_00402 421269 422933 + Formate--tetrahydrofolate ligase Belongs to the formate--tetrahydrofolate ligase family%3B KEGG: hdu:HD1282 formate--tetrahydrofolate ligase gene gene401 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00402 WSWS_00403 WSWS_00403 WSWS_00403 423469 425082 + Oligopeptide-binding protein OppA This protein is a component of the oligopeptide permease%2C a binding protein-dependent transport system%2C It binds peptides up to five amino acids long with high affinity. Also required for sporulation and competence. Belongs to the bacterial solute-binding protein 5 family gene gene402 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00403 WSWS_00404 WSWS_00404 WSWS_00404 425100 426263 + Tryptophan 2-monooxygenase To S. coelicolor SCO1861%3B KEGG: sesp:BN6_37070 tryptophan 2-monooxygenase gene gene403 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00404 WSWS_00405 WSWS_00405 murN murN 426404 427654 + Aminoacyltransferase FemB Catalyzes the formation of the pentaglycine interpeptide bridge%2C which is characteristic of the S. aureus peptidoglycan. Adds glycines 4 and 5 of the pentaglycine bridge%2C using glycyl- tRNA(Gly) as donor. Involved in resistance to methicillin%3B Belongs to the FemABX family%3B KEGG: lge:C269_07870 alanine adding enzyme%3B Aminoacyltransferases gene gene404 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00405 WSWS_00406 WSWS_00406 WSWS_00406 428061 429248 + 2-nitroimidazole transporter Involved in efflux of 2-nitroimidazole%3B Belongs to the major facilitator superfamily. Cyanate porter (TC 2. A. 1. 17) family gene gene405 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00406 WSWS_00407 WSWS_00407 truB truB 429422 430336 + tRNA pseudouridine(55) synthase Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs%3B Belongs to the pseudouridine synthase TruB family. Type 1 subfamily%3B KEGG: cja:CJA_0438 tRNA pseudouridine55 synthase gene gene406 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00407 WSWS_00408 WSWS_00408 ackA ackA 430560 431747 + Acetate kinase Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction%3B Belongs to the acetokinase family%3B KEGG: blr:BRLA_c006350 acetate kinase gene gene407 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00408 WSWS_00409 WSWS_00409 WSWS_00409 431909 432886 + putative HTH-type transcriptional regulator EndR Putative repressor of the endoglucanase operon. Contains 1 HTH lacI-type DNA-binding domain gene gene408 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00409 WSWS_00410 WSWS_00410 kdgK kdgK 433142 433876 + 2-dehydro-3-deoxygluconokinase KEGG: pse:NH8B_4087 2-dehydro-3-deoxygluconokinase gene gene409 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00410 WSWS_00411 WSWS_00411 WSWS_00411 433876 435171 + hypothetical protein gene gene410 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00411 WSWS_00412 WSWS_00412 WSWS_00412 435180 436139 + 2-dehydro-3-deoxygluconokinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: lla:L0021 2-dehydro-3-deoxygluconokinase gene gene411 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00412 WSWS_00413 WSWS_00413 serA serA 436139 437080 + Phosphoglycerate dehydrogenase Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily%3B KEGG: lbh:Lbuc_0633 D-3-phosphoglycerate dehydrogenase gene gene412 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00413 WSWS_00414 WSWS_00414 folC folC 437189 438487 + Dihydrofolate synthase Can complement an H. volcanii mutant strain that is thymidine auxotroph because it lacks the two dihydrofolate reductase genes encoded by hdrA and hdrB%3B In the N-terminal sectio%3B belongs to the folylpolyglutamate synthase family%3B In the C-terminal sectio%3B belongs to the DHPS family%3B Contains 1 pterin-binding domain%3B KEGG: bay:RBAM_025130 dihydrofolate synthase / folylpolyglutamate synthase gene gene413 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00414 WSWS_00415 WSWS_00415 WSWS_00415 438602 439042 + Protein PsiE like protein Belongs to the PsiE family gene gene414 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00415 WSWS_00416 WSWS_00416 WSWS_00416 439154 439939 + DNA repair protein RecO Involved in DNA repair and RecF pathway recombination%3B Belongs to the RecO family gene gene415 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00416 WSWS_00417 WSWS_00417 glyQ glyQ 440245 441171 + Glycine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: ljo:LJ1320 glycyl-tRNA synthetase alpha chain gene gene416 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00417 WSWS_00418 WSWS_00418 glyS glyS 441173 443251 + Glycine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: lpn:lpg1839 glycyl-tRNA synthetase beta chain gene gene417 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00418 WSWS_00419 WSWS_00419 WSWS_00419 443462 443947 + UPF0699 transmembrane protein YdbS Belongs to the UPF0699 family gene gene418 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00419 WSWS_00420 WSWS_00420 WSWS_00420 443937 445460 + UPF0699 transmembrane protein YdbT Belongs to the UPF0699 family gene gene419 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00420 WSWS_00421 WSWS_00421 ruvA ruvA 445598 446191 + DNA helicase RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates%2C in the presence of DNA%2C the weak ATPase activity of RuvB%3B Belongs to the RuvA family%3B KEGG: bck:BCO26_1840 holliday junction DNA helicase RuvA gene gene420 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00421 WSWS_00422 WSWS_00422 ruvB ruvB 446278 447285 + DNA helicase RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing%3B Belongs to the RuvB family%3B KEGG: emi:Emin_0505 holliday junction DNA helicase RuvB gene gene421 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00422 WSWS_00423 WSWS_00423 queA queA 447294 448340 + S-adenosylmethionine:tRNA ribosyltransferase-isomerase Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)%3B Belongs to the QueA family%3B KEGG: lrh:LGG_00754 S-adenosylmethionine:tRNA ribosyltransferase-isomerase gene gene422 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00423 WSWS_00424 WSWS_00424 WSWS_00424 448359 449573 + tRNA-guanine(34) transglycosylase Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp%2C -Asn%2C -His and -Tyr). After this exchange%2C a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine%2C resulting in the hypermodified nucleoside queuosine (Q) (7-(((4%2C5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)%3B Belongs to the queuine tRNA-ribosyltransferase family%3B KEGG: wko:WKK_00795 queuine tRNA-ribosyltransferase gene gene423 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00424 WSWS_00425 WSWS_00425 WSWS_00425 449658 449996 + UPF0092 membrane protein Belongs to the UPF0092 family gene gene424 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00425 WSWS_00426 WSWS_00426 WSWS_00426 450163 450591 + dUTP diphosphatase KEGG: lki:LKI_04310 dUTP pyrophosphatase gene gene425 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00426 WSWS_00427 WSWS_00427 WSWS_00427 450846 451718 + DegV domain-containing protein May bind long-chain fatty acids%2C such as palmitate%2C and may play a role in lipid transport or fatty acid metabolism%3B Contains 1 DegV domain gene gene426 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00427 WSWS_00428 WSWS_00428 nox1 nox1 451813 453138 + NADH oxidase (H(2)O(2)-forming) Catalyzes the four-electron reduction of molecular oxygen to water. Active on beta-NADH%2C but not on alpha-NADH%2C beta- NADPH or alpha-NADPH. Under aerobic conditions%2C oxygen acts as the electron acceptor. Under anaerobic conditions%2C DCIP and MB can replace oxygen as the electron acceptor%3B Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: mmg:MTBMA_c17440 NADH oxidase (H2O2-forming) gene gene427 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00428 WSWS_00429 WSWS_00429 WSWS_00429 453323 453544 + hypothetical protein gene gene428 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00429 WSWS_00430 WSWS_00430 WSWS_00430 453544 453774 + hypothetical protein gene gene429 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00430 WSWS_00431 WSWS_00431 WSWS_00431 453923 454345 + putative HTH-type transcriptional regulator YyaN Contains 1 HTH merR-type DNA-binding domain gene gene430 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00431 WSWS_00432 WSWS_00432 WSWS_00432 454348 455055 + putative oxidoreductase Belongs to the short-chain dehydrogenases/reductases (SDR) family gene gene431 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00432 WSWS_00433 WSWS_00433 WSWS_00433 455066 455443 + hypothetical protein gene gene432 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00433 WSWS_00434 WSWS_00434 WSWS_00434 455605 455733 + hypothetical protein gene gene433 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00434 WSWS_00435 WSWS_00435 WSWS_00435 455755 456426 + hypothetical protein gene gene434 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00435 WSWS_00436 WSWS_00436 WSWS_00436 456491 456799 + hypothetical protein gene gene435 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00436 WSWS_00437 WSWS_00437 WSWS_00437 456923 457621 + hypothetical protein gene gene436 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00437 WSWS_00438 WSWS_00438 WSWS_00438 457805 458299 + hypothetical protein gene gene437 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00438 WSWS_00439 WSWS_00439 WSWS_00439 458534 459310 + Site-specific DNA-methyltransferase (adenine-specific) This methylase recognizes the double-stranded sequence GATC%2C causes specific methylation on A-2 on both strands%2C and protects the DNA from cleavage by the DpnII endonuclease. Belongs to the N(4)/N(6)-methyltransferase family%3B KEGG: lmm:MI1_09386 DNA adenine methylase gene gene438 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00439 WSWS_00440 WSWS_00440 WSWS_00440 459315 460628 + hypothetical protein gene gene439 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00440 WSWS_00441 WSWS_00441 WSWS_00441 460887 461783 + Glucokinase Involved in the pathway of N-acetyl-D-galactosamine degradation. Catalyzes the phosphorylation of N-acetyl-D- galactosamine (GalNAc) to yield D-galactosamine 6-phosphate (GalN- 6-P). It can also phosphorylate N-acetylglucosamine (GlcNAc)%3B Belongs to the ROK (NagC/XylR) family%3B KEGG: aym:YM304_19170 glucokinase gene gene440 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00441 WSWS_00442 WSWS_00442 WSWS_00442 462233 462877 + Arginine ABC transporter permease protein Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene441 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00442 WSWS_00443 WSWS_00443 WSWS_00443 462890 463540 + Methionine import ATP-binding protein MetN Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Methionine importer (TC 3. A. 1. 24) family%3B Contains 1 ABC transporter domain gene gene442 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00443 WSWS_00444 WSWS_00444 WSWS_00444 463545 464375 + L-cystine-binding protein FliY Part of the ABC transporter complex FliY-YecC-YecS involved in L-cystine transport. Binds cystine%3B Belongs to the bacterial solute-binding protein 3 family gene gene443 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00444 WSWS_00445 WSWS_00445 WSWS_00445 464527 465333 + Homoserine kinase Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate%3B Belongs to the GHMP kinase family. Homoserine kinase subfamily%3B KEGG: bcy:Bcer98_1498 homoserine kinase gene gene444 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00445 WSWS_00446 WSWS_00446 WSWS_00446 465379 465750 + Putative fluoride ion transporter CrcB Important for reducing fluoride concentration in the cell%2C thus reducing its toxicity%3B Belongs to the CrcB (TC 9. B. 71) family%3B overlaps another CDS with the same product name gene gene445 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00446 WSWS_00447 WSWS_00447 WSWS_00447 465747 466112 + Putative fluoride ion transporter CrcB Important for reducing fluoride concentration in the cell%2C thus reducing its toxicity%3B Belongs to the CrcB (TC 9. B. 71) family%3B overlaps another CDS with the same product name gene gene446 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00447 WSWS_00448 WSWS_00448 WSWS_00448 466196 466906 + Ribose-5-phosphate isomerase Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate%3B Belongs to the ribose 5-phosphate isomerase family%3B KEGG: lin:lin0974 ribose 5-phosphate isomerase A gene gene447 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00448 WSWS_00449 WSWS_00449 tpiA tpiA 466903 467592 + Triose-phosphate isomerase Belongs to the triosephosphate isomerase family%3B KEGG: lgs:LEGAS_0460 triosephosphate isomerase (TIM) gene gene448 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00449 WSWS_00450 WSWS_00450 WSWS_00450 467951 468700 + Autolysin Hydrolyzes the cell wall of E. faecalis and M. lysodeikticus. May play an important role in cell wall growth and cell separation. Belongs to the glycosyl hydrolase 73 family%3B Contains 6 LysM repeats gene gene449 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00450 WSWS_00451 WSWS_00451 WSWS_00451 468836 469837 + hypothetical protein gene gene450 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00451 WSWS_00452 WSWS_00452 rnhA rnhA 469827 470219 - Ribonuclease H KEGG: lgs:LEGAS_0779 ribonuclease HI gene gene451 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00452 WSWS_00453 WSWS_00453 WSWS_00453 470290 470670 + hypothetical protein gene gene452 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00453 WSWS_00454 WSWS_00454 rluD rluD 470667 471578 + 23S rRNA pseudouridine(1911/1915/1917) synthase Belongs to the pseudouridine synthase RluA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: lrh:LGG_01463 23S rRNA pseudouridine1911/1915/1917 synthase gene gene453 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00454 WSWS_00455 WSWS_00455 pyrR pyrR 471861 472379 + Uracil phosphoribosyltransferase Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator%2C leading to a reduced expression of downstream genes%3B Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily%3B KEGG: spy:SPy_0830 pyrimidine operon attenuation protein / uracil phosphoribosyltransferase gene gene454 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00455 WSWS_00456 WSWS_00456 carA carA 472471 473550 + Carbamoyl-phosphate synthase (glutamine-hydrolyzing) Belongs to the CarA family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: sep:SE0878 carbamoyl-phosphate synthase small subunit gene gene455 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00456 WSWS_00457 WSWS_00457 carB carB 473552 476023 + Carbamoyl-phosphate synthase (glutamine-hydrolyzing) Belongs to the CarB family%3B Contains 2 ATP-grasp domains%3B KEGG: wce:WS08_0866 carbamoyl-phosphate synthase large subunit gene gene456 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00457 WSWS_00458 WSWS_00458 prsA prsA 476146 477081 + Peptidylprolyl isomerase This protein is essential for production of active forms of the serine proteinase located in or secreted from the cell envelope%3B Belongs to the PrsA family%3B Contains 1 PpiC domain%3B KEGG: llc:LACR_C43 foldase protein PrsA gene gene457 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00458 WSWS_00459 WSWS_00459 xynB xynB 477361 478278 + Xylan 1%2C4-beta-xylosidase Activates expression of the rhaBAD and rhaT operons%3B Contains 2 HTH araC/xylS-type DNA-binding domains%3B KEGG: paea:R70723_24165 xylan 1%2C4-beta-xylosidase gene gene458 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00459 WSWS_00460 WSWS_00460 bglX bglX 478326 480410 + Beta-glucosidase Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity)%3B Belongs to the glycosyl hydrolase 3 family%3B Contains 1 PA14 domain%3B KEGG: ttm:Tthe_2487 beta-glucosidase gene gene459 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00460 WSWS_00461 WSWS_00461 WSWS_00461 480403 481584 + hypothetical protein gene gene460 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00461 WSWS_00462 WSWS_00462 WSWS_00462 481718 482161 - hypothetical protein gene gene461 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00462 WSWS_00463 WSWS_00463 WSWS_00463 482295 482483 + hypothetical protein gene gene462 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00463 WSWS_00464 WSWS_00464 WSWS_00464 482540 484006 + putative amino-acid permease Belongs to the amino acid-polyamine-organocation (APC) superfamily gene gene463 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00464 WSWS_00465 WSWS_00465 WSWS_00465 484318 485736 + Pyruvate kinase Belongs to the pyruvate kinase family%3B KEGG: eco:b1854 pyruvate kinase gene gene464 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00465 WSWS_00466 WSWS_00466 WSWS_00466 486218 487675 + 6-phospho-beta-glucosidase Belongs to the glycosyl hydrolase 1 family%3B KEGG: pta:HPL003_10665 6-phospho-beta-glucosidase gene gene465 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00466 WSWS_00467 WSWS_00467 WSWS_00467 487850 488692 + Cryptic beta-glucoside bgl operon antiterminator Mediates the positive regulation of the beta-glucoside (bgl) operon by functioning as a transcriptional antiterminator. This is an RNA-binding protein that recognizes a specific sequence located just upstream of two termination sites within the operon. Belongs to the transcriptional antiterminator BglG family%3B Contains 2 PRD domains gene gene466 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00467 WSWS_00468 WSWS_00468 bglF bglF 488797 490647 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in beta-glucoside transport (By similarity)%3B Contains 1 PTS EIIA type-1 domain%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: kmi:VW41_06310 PTS system%2C beta-glucosides-specific IIA component gene gene467 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00468 WSWS_00469 WSWS_00469 prmA prmA 490886 491842 + Ribosomal protein L11 methyltransferase Methylates ribosomal protein L11%3B Belongs to the methyltransferase superfamily. PrmA family%3B KEGG: lfe:LAF_0808 ribosomal protein L11 methyltransferase%3B Methyltransferases gene gene468 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00469 WSWS_00470 WSWS_00470 rsmE rsmE 491842 492591 + 16S rRNA (uracil(1498)-N(3))-methyltransferase Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)%3B Belongs to the RNA methyltransferase RsmE family%3B KEGG: wce:WS08_0294 16S rRNA (uracil1498-N3)-methyltransferase gene gene469 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00470 WSWS_00471 WSWS_00471 WSWS_00471 492594 492977 + hypothetical protein gene gene470 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00471 WSWS_00472 WSWS_00472 WSWS_00472 493367 493798 + Transcriptional regulator MraZ Belongs to the MraZ family%3B Contains 2 SpoVT-AbrB domains gene gene471 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00472 WSWS_00473 WSWS_00473 mraW mraW 493821 494765 + 16S rRNA (cytosine(1402)-N(4))-methyltransferase Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA%3B Belongs to the methyltransferase superfamily. RsmH family%3B KEGG: lfe:LAF_0569 16S rRNA (cytosine1402-N4)-methyltransferase gene gene472 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00473 WSWS_00474 WSWS_00474 WSWS_00474 494791 495162 + hypothetical protein gene gene473 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00474 WSWS_00475 WSWS_00475 WSWS_00475 495257 497404 + Penicillin-binding protein 2B Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. PBP-2B is required for vegetative cell division and sporulation septation. Beta-lactamase inactivates the PBPs by acylating an essential serine residue in the active site of these proteins%2C thereby interrupting normal cell wall synthesis. Belongs to the transpeptidase family%3B Contains 2 PASTA domains gene gene474 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00475 WSWS_00476 WSWS_00476 mraY mraY 497442 498443 + Phospho-N-acetylmuramoyl-pentapeptide-transferase First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan%3B Belongs to the glycosyltransferase 4 family. MraY subfamily%3B KEGG: wko:WKK_01240 phospho-N-acetylmuramoyl-pentapeptide-transferase gene gene475 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00476 WSWS_00477 WSWS_00477 murD murD 498496 499851 + UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)%3B Belongs to the MurCDEF family%3B KEGG: wko:WKK_01235 UDP-N-acetylmuramoylalanine--D-glutamate ligase gene gene476 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00477 WSWS_00478 WSWS_00478 murG murG 499854 500957 + Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)%3B Belongs to the glycosyltransferase 28 family. MurG subfamily%3B KEGG: wko:WKK_01230 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase gene gene477 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00478 WSWS_00479 WSWS_00479 WSWS_00479 500979 501887 + Cell division protein DivIB Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex%3B Belongs to the FtsQ/DivIB family. DivIB subfamily%3B Contains 1 POTRA domain gene gene478 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00479 WSWS_00480 WSWS_00480 WSWS_00480 502134 503486 + Cell division protein FtsA Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring%3B Belongs to the FtsA/MreB family gene gene479 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00480 WSWS_00481 WSWS_00481 WSWS_00481 503605 504825 + Cell division protein FtsZ like protein 1%2C chloroplastic Exhibits GTPase activity. Component of the plastid division machinery that forms a contractile ring at the division site. Required for plastid division in a dose-dependent manner. Involved in blue light-induced chloroplast movements. May regulate thylakoid development%3B Belongs to the FtsZ family gene gene480 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00481 WSWS_00482 WSWS_00482 WSWS_00482 504838 505305 + Cell division protein SepF Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation%2C perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA%3B Belongs to the SepF family gene gene481 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00482 WSWS_00483 WSWS_00483 WSWS_00483 505320 505592 + putative membrane protein YlmG Belongs to the YggT family gene gene482 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00483 WSWS_00484 WSWS_00484 WSWS_00484 505594 506379 + Putative RNA-binding protein YlmH Contains 1 S4 RNA-binding domain gene gene483 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00484 WSWS_00485 WSWS_00485 WSWS_00485 506395 507042 + Septum site-determining protein DivIVA May act as a pilot protein%2C directing MinCD to the polar septation sites or by inhibiting MinCD at the midcell site of division. Required for polar localization of the chromosome during sporulation%3B Belongs to the DivIVA family gene gene484 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00485 WSWS_00486 WSWS_00486 iarS iarS 507299 510097 + Isoleucine--tRNA ligase Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine%2C to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)%3B Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily%3B KEGG: lla:L0350 isoleucyl-tRNA synthetase gene gene485 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00486 WSWS_00487 WSWS_00487 WSWS_00487 510420 511358 + hypothetical protein gene gene486 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00487 WSWS_00488 WSWS_00488 WSWS_00488 511507 512274 + Multidrug resistance-like ATP-binding protein Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3. A. 1. 117) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene487 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00488 WSWS_00489 WSWS_00489 WSWS_00489 512281 513063 + Phosphite transport system permease protein PtxC Probably forms part of a binding-protein-dependent phosphite transporter. Probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family%3B Contains 1 ABC transmembrane type-1 domain gene gene488 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00489 WSWS_00490 WSWS_00490 WSWS_00490 513063 513857 + Phosphate-import permease protein PhnE Part of the ABC transporter complex PhnCDE involved in phosphate import. Responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family%3B Contains 2 ABC transmembrane type-1 domains gene gene489 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00490 WSWS_00491 WSWS_00491 dpo4 dpo4 513952 515067 + DNA-directed DNA polymerase Poorly processive%2C error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks%2C which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis (By similarity)%3B Belongs to the DNA polymerase type-Y family%3B Contains 1 umuC domain%3B KEGG: wce:WS08_0399 DNA polymerase IV gene gene490 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00491 WSWS_00492 WSWS_00492 WSWS_00492 515155 516102 + putative bifunctional oligoribonuclease and PAP phosphatase NrnA Probable bifunctional enzyme which has pAp-phosphatase and may have oligoribonuclease activities. Converts 3'(2')- phosphoadenosine 5'-phosphate (PAP) to AMP. Complementation studies suggest it also has RNA oligoribonuclease activity%2C although this has not been shown in vitro using 5- or 20-mers. Involved in superoxide stress response and sulfur assimilation%3B Belongs to the NrnA oligoribonuclease family gene gene491 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00492 WSWS_00493 WSWS_00493 deaD deaD 516102 517460 + RNA helicase Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. Unwinds dsRNA in both 5'- and 3'-directions and shows RNA-dependent ATPase activity (By similarity). Probably has a somewhat redundant function with CshA%2C as cshA can partially complement the growth effects of a cshB deletion%3B Belongs to the DEAD box helicase family. CshB subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: baci:B1NLA3E_13040 ATP-dependent RNA helicase DeaD gene gene492 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00493 WSWS_00494 WSWS_00494 WSWS_00494 517551 518336 + Methionyl aminopeptidase Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-%2C Cys%2C Gly%2C Pro%2C Ser%2C Thr%2C or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed%3B Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily%3B KEGG: bmq:BMQ_0308 methionyl aminopeptidase gene gene493 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00494 WSWS_00495 WSWS_00495 aroD aroD 518462 519181 + 3-dehydroquinate dehydratase Involved in the third step of the chorismate pathway%2C which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate%3B Belongs to the type-I 3-dehydroquinase family%3B KEGG: wce:WS08_0826 3-dehydroquinate dehydratase I gene gene494 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00495 WSWS_00496 WSWS_00496 WSWS_00496 519231 520289 + Putative competence protein CoiA Required for optimal transformation gene gene495 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00496 WSWS_00497 WSWS_00497 WSWS_00497 520350 522161 + Oligoendopeptidase F like protein Belongs to the peptidase M3B family%3B KEGG: hor:Hore_08170 oligoendopeptidase F%3B Metalloendopeptidases gene gene496 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00497 WSWS_00498 WSWS_00498 WSWS_00498 522337 523023 + Ribosome maturation factor RimP Required for maturation of 30S ribosomal subunits%3B Belongs to the RimP family gene gene497 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00498 WSWS_00499 WSWS_00499 WSWS_00499 523036 524205 + Transcription termination/antitermination protein NusA Participates in both transcription termination and antitermination%3B Belongs to the NusA family%3B Contains 1 KH domain%3B Contains 1 S1 motif domain gene gene498 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00499 WSWS_00500 WSWS_00500 WSWS_00500 524233 524532 + uncharacterized protein gene gene499 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00500 WSWS_00501 WSWS_00501 WSWS_00501 524522 524827 + putative ribosomal protein YlxQ RNA-binding protein that recognizes the K-turn motif present in ribosomal RNA%2C but also in box C/D and box C'/D' sRNAs%3B Belongs to the ribosomal protein L7Ae family gene gene500 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00501 WSWS_00502 WSWS_00502 WSWS_00502 524838 527096 + Translation initiation factor IF-2 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene501 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00502 WSWS_00503 WSWS_00503 WSWS_00503 527155 527517 + Ribosome-binding factor Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA%3B Belongs to the RbfA family gene gene502 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00503 WSWS_00504 WSWS_00504 WSWS_00504 527754 528626 + Conserved virulence factor Belongs to the CvfB family gene gene503 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00504 WSWS_00505 WSWS_00505 WSWS_00505 528626 529537 + Tyrosine recombinase XerD Site-specific tyrosine recombinase%2C which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids%3B Belongs to the 'phage' integrase family. XerD subfamily gene gene504 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00505 WSWS_00506 WSWS_00506 WSWS_00506 529551 529916 + hypothetical protein gene gene505 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00506 WSWS_00507 WSWS_00507 WSWS_00507 529909 530709 + Segregation and condensation protein Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves%3B Belongs to the ScpA family%3B overlaps another CDS with the same product name gene gene506 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00507 WSWS_00508 WSWS_00508 WSWS_00508 530687 531322 + Segregation and condensation protein Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves%3B Belongs to the ScpB family%3B overlaps another CDS with the same product name gene gene507 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00508 WSWS_00509 WSWS_00509 rluB rluB 531323 532069 + 23S rRNA pseudouridine(2605) synthase Belongs to the pseudouridine synthase RsuA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: pat:Patl_2824 23S rRNA pseudouridine2605 synthase gene gene508 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00509 WSWS_00510 WSWS_00510 WSWS_00510 532464 533036 + Riboflavin transporter RibU Probable riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane%2C not extracytoplasmic soluble proteins and transport it into cells (By similarity)%3B Belongs to the prokaryotic riboflavin transporter (P- RFT) (TC 2. A. 87) family gene gene509 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00510 WSWS_00511 WSWS_00511 WSWS_00511 533109 534155 + hypothetical protein gene gene510 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00511 WSWS_00512 WSWS_00512 recQ recQ 534158 535603 + DNA helicase DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity)%3B Belongs to the helicase family. RecQ subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: bbw:BDW_03395 ATP-dependent DNA helicase RecQ gene gene511 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00512 WSWS_00513 WSWS_00513 WSWS_00513 535740 536327 + Lysozyme Mediates binding to human platelets%2C possibly through a receptor-ligand interaction%3B Belongs to the SraP family%3B KEGG: ooe:OEOE_1199 lysozyme gene gene512 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00513 WSWS_00514 WSWS_00514 WSWS_00514 536432 537106 + UMP/CMP kinase Belongs to the cytidylate kinase family. Type 1 subfamily%3B KEGG: pln:Plano_1799 cytidylate kinase gene gene513 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00514 WSWS_00515 WSWS_00515 WSWS_00515 537241 538509 + 30S Ribosomal protein S1 Binds mRN%3B thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)%3B Belongs to the ribosomal protein S1P family%3B Contains 4 S1 motif domains gene gene514 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00515 WSWS_00516 WSWS_00516 WSWS_00516 538703 540013 + GTPase Der GTPase that plays an essential role in the late steps of ribosome biogenesis%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngA (Der) GTPase family%3B Contains 2 EngA-type G (guanine nucleotide-binding) domains%3B Contains 1 KH-like domain gene gene515 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00516 WSWS_00517 WSWS_00517 WSWS_00517 540284 540556 + Integration host factor subunit alpha This protein is one of the two subunits of integration host factor%2C a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control%3B Belongs to the bacterial histone-like protein family gene gene516 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00517 WSWS_00518 WSWS_00518 WSWS_00518 540719 541309 + hypothetical protein gene gene517 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00518 WSWS_00519 WSWS_00519 WSWS_00519 541311 541805 + hypothetical protein gene gene518 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00519 WSWS_00520 WSWS_00520 WSWS_00520 541874 542467 + Peptide deformylase Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions%3B Belongs to the polypeptide deformylase family%3B KEGG: baco:OXB_1901 peptide deformylase gene gene519 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00520 WSWS_00521 WSWS_00521 WSWS_00521 542406 542756 + UPF0223 protein Belongs to the UPF0223 family gene gene520 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00521 WSWS_00522 WSWS_00522 impA impA 542759 543538 + Inositol-phosphate phosphatase Belongs to the inositol monophosphatase family%3B KEGG: lbh:Lbuc_0741 myo-inositol-1(or 4)-monophosphatase gene gene521 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00522 WSWS_00523 WSWS_00523 WSWS_00523 543637 545475 + Elongation factor Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step%2C the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites%2C respectively. Catalyzes the coordinated movement of the two tRNA molecules%2C the mRNA and conformational changes in the ribosome%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene522 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00523 WSWS_00524 WSWS_00524 WSWS_00524 545603 546892 + Putative lipid II flippase FtsW Essential cell division protein. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane (By similarity)%3B Belongs to the SEDS family. FtsW subfamily gene gene523 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00524 WSWS_00525 WSWS_00525 WSWS_00525 546892 547206 + UPF0298 protein Belongs to the UPF0298 family gene gene524 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00525 WSWS_00526 WSWS_00526 rsmD rsmD 547216 547773 + 16S rRNA (guanine(966)-N(2))-methyltransferase Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle%3B Belongs to the methyltransferase superfamily. RsmD family%3B KEGG: hhs:HHS_01250 16S rRNA (guanine966-N2)-methyltransferase gene gene525 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00526 WSWS_00527 WSWS_00527 coaD coaD 547773 548258 + Pantetheine-phosphate adenylyltransferase Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine%2C yielding dephospho-CoA (dPCoA) and pyrophosphate%3B Belongs to the bacterial CoaD family%3B KEGG: vch:VC0222 pantetheine-phosphate adenylyltransferase gene gene526 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00527 WSWS_00528 WSWS_00528 WSWS_00528 548265 549332 + uncharacterized protein Contains 1 PDZ (DHR) domain gene gene527 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00528 WSWS_00529 WSWS_00529 WSWS_00529 549611 550216 + Putative 5'(3')-deoxyribonucleotidase Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides%3B Belongs to the 5'(3')-deoxyribonucleotidase family gene gene528 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00529 WSWS_00530 WSWS_00530 fbaA fbaA 550218 551102 + Fructose-bisphosphate aldolase Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1%2C6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis%3B Belongs to the class II fructose-bisphosphate aldolase family%3B KEGG: kfl:Kfla_5876 fructose-bisphosphate aldolase%2C class II gene gene529 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00530 WSWS_00531 WSWS_00531 WSWS_00531 551251 551478 + hypothetical protein gene gene530 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00531 WSWS_00532 WSWS_00532 WSWS_00532 551475 552011 + putative transmembrane protein YshB gene gene531 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00532 WSWS_00533 WSWS_00533 WSWS_00533 552030 554411 + Endonuclease MutS2 Belongs to the DNA mismatch repair MutS family. MutS2 subfamily%3B Contains 1 Smr domain gene gene532 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00533 WSWS_00534 WSWS_00534 WSWS_00534 554555 554983 + hypothetical protein gene gene533 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00534 WSWS_00535 WSWS_00535 WSWS_00535 555124 555753 + Phosphoglycolate phosphatase Belongs to the HAD-like hydrolase superfamily. PpaX family%3B KEGG: mear:Mpt1_c06470 phosphoglycolate phosphatase gene gene534 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00535 WSWS_00536 WSWS_00536 murI murI 555812 556660 + Glutamate racemase Provides the (R)-glutamate required for cell wall biosynthesis%3B Belongs to the aspartate/glutamate racemases family%3B KEGG: wko:WKK_05960 glutamate racemase gene gene535 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00536 WSWS_00537 WSWS_00537 rdgB rdgB 556662 557261 + XTP/dITP diphosphatase Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool%2C thus preventing their incorporation into DNA and avoiding chromosomal lesions%3B Belongs to the HAM1 NTPase family%3B KEGG: cls:CXIVA_01010 XTP/dITP diphosphohydrolase gene gene536 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00537 WSWS_00538 WSWS_00538 WSWS_00538 557264 557782 + Putative metallophosphoesterase YsnB Belongs to the metallophosphoesterase superfamily. YfcE family gene gene537 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00538 WSWS_00539 WSWS_00539 WSWS_00539 557952 559247 + Dihydrofolate synthase Conversion of folates to polyglutamate derivatives. It prefers 5%2C10-methylenetetrahydrofolate%2C rather than 10- formyltetrahydrofolate as folate substrate. Belongs to the folylpolyglutamate synthase family%3B KEGG: lbh:Lbuc_1095 dihydrofolate synthase / folylpolyglutamate synthase gene gene538 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00539 WSWS_00540 WSWS_00540 WSWS_00540 559247 559873 + XTP/dITP diphosphatase KEGG: pce:PECL_1084 XTP/dITP diphosphohydrolase gene gene539 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00540 WSWS_00541 WSWS_00541 murE murE 559916 561445 + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopimelate ligase Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan%3B Belongs to the MurCDEF family. MurE subfamily%3B KEGG: bde:BDP_1521 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopimelate ligase gene gene540 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00541 WSWS_00542 WSWS_00542 WSWS_00542 561542 561886 + hypothetical protein gene gene541 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00542 WSWS_00543 WSWS_00543 rarS rarS 561888 563582 + Arginine--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: lpl:lp_1391 arginyl-tRNA synthetase gene gene542 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00543 WSWS_00544 WSWS_00544 WSWS_00544 563842 564543 + Trehalose operon transcriptional repressor Repressor for the trehalose operon (treP and treA). Binds trehalose-6-phosphate%2C which probably acts as an inducer. Contains 1 HTH gntR-type DNA-binding domain gene gene543 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00544 WSWS_00545 WSWS_00545 scrA scrA 564558 565040 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport (By similarity)%3B Contains 1 PTS EIIA type-1 domain%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: lpk:LACPI_1481 PTS system%2C sucrose-specific IIA component gene gene544 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00545 WSWS_00546 WSWS_00546 WSWS_00546 565053 566558 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in trehalose transport. Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: lsa:LSA1200 PTS system%2C beta-glucosides-specific IIB component gene gene545 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00546 WSWS_00547 WSWS_00547 treC treC 566579 568195 + Alpha%2Calpha-phosphotrehalase Belongs to the glycosyl hydrolase 13 family%3B KEGG: emu:EMQU_0426 trehalose-6-phosphate hydrolase gene gene546 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00547 WSWS_00548 WSWS_00548 WSWS_00548 568456 568842 + UPF0478 protein Belongs to the UPF0478 family gene gene547 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00548 WSWS_00549 WSWS_00549 WSWS_00549 568891 569499 + hypothetical protein gene gene548 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00549 WSWS_00550 WSWS_00550 mgmT mgmT 569653 570150 + Methylated-DNA--[protein]-cysteine S-methyltransferase Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs O6- methylguanine and 04-methylthymine residues in alkylated DNA by a direct and irreversible transfer of the methyl group from the base to one of its own cysteine residues (Cys-321). Also specifically repairs the Sp diastereomer of DNA methylphosphotriester lesions by the same mechanism%2C although the methyl transfer occurs onto a different cysteine residue (Cys-38). Can not demethylate the other diastereomer%2C Rp-methylphosphotriester%3B The methylation of Ada by methylphosphotriesters in DNA leads to its activation as a transcriptional regulator that activates the transcription of its own gene%2C ada%2C and other alkylation resistance genes%2C alkA%2C alkB and aidB%3B In the C-terminal sectio%3B belongs to the MGMT family%3B Contains 1 HTH araC/xylS-type DNA-binding domain%3B KEGG: lsa:LSA1843 methylated-DNA-(protein)-cysteine S-methyltransferase gene gene549 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00550 WSWS_00551 WSWS_00551 WSWS_00551 570213 570791 + hypothetical protein gene gene550 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00551 WSWS_00552 WSWS_00552 WSWS_00552 571008 571928 + Cation efflux system protein CzcD Necessary for activation of the czc determinant. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2. A. 4) family. SLC30A subfamily gene gene551 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00552 WSWS_00553 WSWS_00553 WSWS_00553 572153 573700 + putative MFS-type transporter YcnB Belongs to the major facilitator superfamily. EmrB family gene gene552 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00553 WSWS_00554 WSWS_00554 WSWS_00554 573700 574452 + hypothetical protein gene gene553 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00554 WSWS_00555 WSWS_00555 WSWS_00555 574649 575038 + Putative DNA-binding protein YwzG gene gene554 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00555 WSWS_00556 WSWS_00556 WSWS_00556 575035 576432 + hypothetical protein gene gene555 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00556 WSWS_00557 WSWS_00557 WSWS_00557 576454 576642 + putative membrane protein YvlC gene gene556 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00557 WSWS_00558 WSWS_00558 WSWS_00558 576847 577941 + hypothetical protein gene gene557 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00558 WSWS_00559 WSWS_00559 WSWS_00559 578099 578749 + Zinc import ATP-binding protein ZnuC Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Zinc importer (TC 3. A. 1. 15. 5) family%3B Contains 1 ABC transporter domain%3B KEGG: sod:Sant_1689 zinc transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene558 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00559 WSWS_00560 WSWS_00560 WSWS_00560 578742 579515 + putative iron export permease protein FetB Part of the ABC transporter complex FetAB%2C which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for the translocation of the substrate across the membrane%3B Belongs to the UPF0014 family gene gene559 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00560 WSWS_00561 WSWS_00561 WSWS_00561 579674 581383 + hypothetical protein gene gene560 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00561 WSWS_00562 WSWS_00562 tagF tagF 581431 583170 - CDP-glycerol glycerophosphotransferase KEGG: lcn:C270_02980 CDP-glycerol glycerophosphotransferase gene gene561 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00562 WSWS_00563 WSWS_00563 dpm1 dpm1 583358 584287 + Dolichyl-phosphate beta-D-mannosyltransferase Belongs to the glycosyltransferase 2 family. GtrB subfamily%3B KEGG: ppn:Palpr_0625 dolichol-phosphate mannosyltransferase gene gene562 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00563 WSWS_00564 WSWS_00564 WSWS_00564 584358 585281 + Rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1%2C3/1%2C4-galactofuranosyltransferase KEGG: cgl:NCgl0195 rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1%2C3/1%2C4-galactofuranosyltransferase gene gene563 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00564 WSWS_00565 WSWS_00565 tagH tagH 585418 586506 + Teichoic-acid-transporting ATPase Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Teichoic acids exporter (TC 3. A. 1. 104. 1) family%3B Contains 1 ABC transporter domain%3B KEGG: lcn:C270_02945 teichoic acid transport system ATP-binding protein gene gene564 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00565 WSWS_00566 WSWS_00566 WSWS_00566 586518 587336 + Teichoic acid translocation permease protein TagG Part of the ABC transporter complex TagGH (TC 3. A. 1. 34. 1) involved in exporting the two types of intracellularly synthesized teichoic acids. Probably responsible for the translocation of the substrate across the membrane. Belongs to the ABC-2 integral membrane protein family%3B Contains 1 ABC transmembrane type-2 domain gene gene565 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00566 WSWS_00567 WSWS_00567 WSWS_00567 587424 588890 + hypothetical protein gene gene566 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00567 WSWS_00568 WSWS_00568 WSWS_00568 588887 589258 + hypothetical protein gene gene567 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00568 WSWS_00569 WSWS_00569 pdxK pdxK 589422 590216 + Pyridoxal kinase Phosphorylates B6 vitamer%3B functions in a salvage pathway. Uses pyridoxal%2C pyridoxine%2C and pyridoxamine as substrates (By similarity)%3B Belongs to the ThiD family%3B KEGG: seq:SZO_02460 pyridoxine kinase gene gene568 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00569 WSWS_00570 WSWS_00570 WSWS_00570 590233 590754 + Thiamine precursor transporter HmpT Probably a thiamine precursor-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane%2C not extracytoplasmic soluble proteins gene gene569 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00570 WSWS_00571 WSWS_00571 WSWS_00571 590991 592340 + putative MFS-type transporter Belongs to the major facilitator superfamily gene gene570 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00571 WSWS_00572 WSWS_00572 mrcA mrcA 592473 594962 - Penicillin-binding protein 1A Cell wall formation. In the N-terminal sectio%3B belongs to the glycosyltransferase 51 family%3B In the C-terminal sectio%3B belongs to the transpeptidase family%3B KEGG: efa:EF1148 penicillin-binding protein 1A%3B Hexosyltransferases gene gene571 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00572 WSWS_00573 WSWS_00573 WSWS_00573 594995 595597 - Holliday junction resolvase RecU Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands%3B Belongs to the RecU family gene gene572 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00573 WSWS_00574 WSWS_00574 WSWS_00574 595721 596281 + UPF0398 protein Belongs to the UPF0398 family gene gene573 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00574 WSWS_00575 WSWS_00575 WSWS_00575 596446 596808 + Cell cycle protein GpsB Divisome component that associates with the complex late in its assembly%2C after the Z-ring is formed%2C and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA%2C is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation%3B Belongs to the GpsB family gene gene574 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00575 WSWS_00576 WSWS_00576 WSWS_00576 597377 598096 + putative membrane protein Belongs to the BI1 family gene gene575 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00576 WSWS_00577 WSWS_00577 dpo1 dpo1 598222 600930 + DNA-directed DNA polymerase In addition to polymerase activity%2C this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity%3B Belongs to the DNA polymerase type-A family%3B Contains 1 3'-5' exonuclease domain%3B Contains 1 5'-3' exonuclease domain%3B KEGG: wce:WS08_0499 DNA polymerase I gene gene576 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00577 WSWS_00578 WSWS_00578 WSWS_00578 601119 602108 + Ribonuclease Z Zinc phosphodiesterase%2C which has both exoribonuclease and endoribonuclease activities%3B Belongs to the RNase Z family. RNase BN subfamily%3B KEGG: eta:ETA_33250 ribonuclease Z gene gene577 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00578 WSWS_00579 WSWS_00579 recJ recJ 602136 604436 + Single-stranded-DNA-specific exonuclease RecJ Putative single-stranded-DNA-specific exonuclease (By similarity). RecA thread formation during DNA double-strand break repair requires RecJ or AadAB%3B Belongs to the RecJ family%3B Contains 1 OB DNA-binding domain%3B KEGG: sub:SUB1129 single-stranded-DNA-specific exonuclease%3B Acting on ester bonds gene gene578 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00579 WSWS_00580 WSWS_00580 aprT aprT 604454 604981 + Adenine phosphoribosyltransferase Catalyzes a salvage reaction resulting in the formation of AMP%2C that is energically less costly than de novo synthesis%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family%3B KEGG: afl:Aflv_0725 adenine phosphoribosyltransferase gene gene579 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00580 WSWS_00581 WSWS_00581 harS harS 605284 606597 + Histidine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: lci:LCK_00667 histidyl-tRNA synthetase gene gene580 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00581 WSWS_00582 WSWS_00582 darS darS 606597 608399 + Aspartate--tRNA ligase Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn)%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: lla:L0346 aspartyl-tRNA synthetase gene gene581 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00582 WSWS_00583 WSWS_00583 WSWS_00583 608536 609417 + UPF0750 membrane protein YitT Belongs to the UPF0750 family gene gene582 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00583 WSWS_00584 WSWS_00584 WSWS_00584 609558 610055 + Nucleoside deoxyribosyltransferase KEGG: lme:LEUM_0444 nucleoside deoxyribosyltransferase gene gene583 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00584 WSWS_00585 WSWS_00585 gpmB gpmB 610411 611070 + Phosphoglycerate mutase (2%2C3-diphosphoglycerate-independent) Belongs to the phosphoglycerate mutase family. GpmB subfamily%3B KEGG: eco:b4395 probable phosphoglycerate mutase gene gene584 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00585 WSWS_00586 WSWS_00586 WSWS_00586 611122 611754 - Carbonate dehydratase Reversible hydration of carbon dioxide%3B Belongs to the alpha-class carbonic anhydrase family%3B KEGG: ooe:OEOE_0238 carbonic anhydrase gene gene585 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00586 WSWS_00587 WSWS_00587 WSWS_00587 611914 612339 + Nucleoside-diphosphate kinase Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism%2C using a phosphorylated active-site intermediate%3B Belongs to the NDK family%3B KEGG: dde:Dde_1439 nucleoside-diphosphate kinase gene gene586 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00587 WSWS_00588 WSWS_00588 WSWS_00588 612397 613113 - putative transcriptional regulatory protein Belongs to the TACO1 family. YeeN subfamily gene gene587 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00588 WSWS_00589 WSWS_00589 WSWS_00589 613262 614449 + Long-chain-alcohol dehydrogenase Long-chain alkyl alcohol dehydrogenase that can oxidize a broad range of alkyl alcohols from methanol to 1-triacontanol (C1 to C30) as well as 1%2C3-propanediol and acetaldehyde. Oxidizes isopropyl alcohol%2C isoamylol%2C acetone%2C octanal and decanal. The best substrate is 1-octanol%3B Belongs to the iron-containing alcohol dehydrogenase family%3B KEGG: aac:Aaci_0910 null%3B With NAD(+) or NADP(+) as acceptor gene gene588 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00589 WSWS_00590 WSWS_00590 WSWS_00590 614810 615703 + Phosphate-binding protein PstS Part of the ABC transporter complex PstSACB involved in phosphate import%3B Belongs to the PstS family gene gene589 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00590 WSWS_00591 WSWS_00591 WSWS_00591 616178 617806 + Oligopeptide-binding protein OppA This protein is a component of the oligopeptide permease%2C a binding protein-dependent transport system%2C It binds peptides up to five amino acids long with high affinity. Also required for sporulation and competence. Belongs to the bacterial solute-binding protein 5 family gene gene590 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00591 WSWS_00592 WSWS_00592 WSWS_00592 617918 618820 - UPF0750 membrane protein YdeO Belongs to the UPF0750 family gene gene591 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00592 WSWS_00593 WSWS_00593 WSWS_00593 618928 619470 - hypothetical protein gene gene592 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00593 WSWS_00594 WSWS_00594 WSWS_00594 619599 620642 - Isopentenyl-diphosphate Delta-isomerase Involved in the biosynthesis of isoprenoids. Catalyzes the 1%2C3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer%2C dimethylallyl diphosphate (DMAPP)%3B Belongs to the IPP isomerase type 2 family%3B KEGG: ooe:OEOE_1103 isopentenyl-diphosphate delta-isomerase gene gene593 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00594 WSWS_00595 WSWS_00595 WSWS_00595 620652 621686 - Phosphomevalonate kinase Catalyzes the phosphorylation of (R)-mevalonate 5- phosphate (MVAP) to (R)-mevalonate 5-diphosphate (MVAPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP)%2C a key precursor for the biosynthesis of isoprenoid compounds%3B Belongs to the GHMP kinase family%3B KEGG: sst:SSUST3_0300 phosphomevalonate kinase gene gene594 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00595 WSWS_00596 WSWS_00596 mvaD mvaD 621686 622672 - Diphosphomevalonate decarboxylase Catalyzes the decarboxylation of mevalonate 5-phosphate (MVAP) to isopentenyl phosphate (IP). Functions in an alternate mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP)%2C a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids%3B Belongs to the phosphomevalonate decarboxylase family%3B KEGG: lgr:LCGT_0282 diphosphomevalonate decarboxylase gene gene595 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00596 WSWS_00597 WSWS_00597 WSWS_00597 622684 623622 - Mevalonate kinase Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP)%2C a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids%3B Belongs to the GHMP kinase family. Mevalonate kinase subfamily%3B KEGG: lpl:lp_1735 mevalonate kinase gene gene596 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00597 WSWS_00598 WSWS_00598 dinG dinG 623847 626675 + DNA helicase Probable helicase involved in DNA repair and perhaps also replication%3B Belongs to the helicase family. DinG subfamily%3B Contains 1 exonuclease domain%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: ecas:ECBG_01904 ATP-dependent DNA helicase DinG gene gene597 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00598 WSWS_00599 WSWS_00599 WSWS_00599 626741 627250 + hypothetical protein gene gene598 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00599 WSWS_00600 WSWS_00600 narS narS 627272 628567 + Asparagine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: lca:LSEI_1485 asparaginyl-tRNA synthetase gene gene599 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00600 WSWS_00601 WSWS_00601 WSWS_00601 628658 629389 + DNA replication protein DnaD gene gene600 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00601 WSWS_00602 WSWS_00602 WSWS_00602 629421 630257 + hypothetical protein gene gene601 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00602 WSWS_00603 WSWS_00603 WSWS_00603 630344 631561 + CCA-adding enzyme Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C%2C C%2C and A to the tRNA nucleotide-73%2C using CTP and ATP as substrates and producing inorganic pyrophosphate%3B Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily%3B KEGG: wce:WS08_0747 tRNA nucleotidyltransferase (CCA-adding enzyme)%3B CCA tRNA nucleotidyltransferase gene gene602 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00603 WSWS_00604 WSWS_00604 lptB lptB 631567 633468 + Energy-dependent translational throttle protein EttA A translation factor that gates the progression of the 70S ribosomal inititation complex (IC%2C containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation (By similarity)%3B Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily%3B Contains 2 ABC transporter domains%3B KEGG: bav:BAV3118 lipopolysaccharide export system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene603 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00604 WSWS_00605 WSWS_00605 folA folA 633468 633965 + Dihydrofolate reductase Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis%2C and for DNA precursor synthesis (By similarity)%3B Belongs to the dihydrofolate reductase family%3B Contains 1 DHFR (dihydrofolate reductase) domain%3B KEGG: wko:WKK_06245 dihydrofolate reductase gene gene604 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00605 WSWS_00606 WSWS_00606 WSWS_00606 634091 634300 + hypothetical protein gene gene605 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00606 WSWS_00607 WSWS_00607 dnaE dnaE 634412 637789 + DNA-directed DNA polymerase DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity)%3B Belongs to the DNA polymerase type-C family. DnaE subfamily%3B KEGG: wko:WKK_06255 DNA polymerase III subunit alpha gene gene606 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00607 WSWS_00608 WSWS_00608 WSWS_00608 637909 638862 + hypothetical protein gene gene607 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00608 WSWS_00609 WSWS_00609 WSWS_00609 638998 641370 + Xaa-Pro dipeptidyl-peptidase Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Belongs to the peptidase S15 family%3B KEGG: llc:LACR_2342 X-Pro dipeptidyl-peptidase gene gene608 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00609 WSWS_00610 WSWS_00610 WSWS_00610 641379 642584 + hypothetical protein gene gene609 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00610 WSWS_00611 WSWS_00611 WSWS_00611 642762 643493 + Response regulator ArlR Member of the two-component regulatory system ArlS/ArlR%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene610 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00611 WSWS_00612 WSWS_00612 phoR phoR 643497 644897 + Histidine kinase Member of the two-component regulatory system PhoP/PhoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoP in response to environmental signals. Contains 1 histidine kinase domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: wce:WS08_0493 two-component system%2C OmpR family%2C phosphate regulon sensor histidine kinase PhoR gene gene611 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00612 WSWS_00613 WSWS_00613 WSWS_00613 645037 645672 + Uridine kinase Belongs to the uridine kinase family%3B KEGG: bsu:BSU27330 uridine kinase gene gene612 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00613 WSWS_00614 WSWS_00614 pepA pepA 645714 646787 + Glutamyl aminopeptidase Belongs to the peptidase M42 family%3B KEGG: lmm:MI1_07170 glutamyl aminopeptidase gene gene613 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00614 WSWS_00615 WSWS_00615 WSWS_00615 646794 647441 + Phenylalanine--tRNA ligase beta subunit Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily%3B Contains 1 B5 domain%3B Contains 1 FDX-ACB domain%3B Contains 1 tRNA-binding domain gene gene614 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00615 WSWS_00616 WSWS_00616 WSWS_00616 647452 647721 + hypothetical protein gene gene615 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00616 WSWS_00617 WSWS_00617 WSWS_00617 647987 648544 + hypothetical protein gene gene616 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00617 WSWS_00618 WSWS_00618 WSWS_00618 648637 649731 + hypothetical protein gene gene617 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00618 WSWS_00619 WSWS_00619 murC murC 650145 651485 + UDP-N-acetylmuramate--L-alanine ligase Cell wall formation%3B Belongs to the MurCDEF family%3B KEGG: ppe:PEPE_0686 UDP-N-acetylmuramate--alanine ligase gene gene618 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00619 WSWS_00620 WSWS_00620 mutM mutM 651600 652427 + DNA-formamidopyrimidine glycosylase Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines%2C such as 7%2C8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates%3B Belongs to the FPG family%3B Contains 1 FPG-type zinc finger%3B KEGG: xfa:XF0071 formamidopyrimidine-DNA glycosylase gene gene619 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00620 WSWS_00621 WSWS_00621 coaE coaE 652448 653050 + Dephospho-CoA kinase Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A%3B Belongs to the CoaE family%3B Contains 1 DPCK (dephospho-CoA kinase) domain%3B KEGG: cbu:CBU_0152 dephospho-CoA kinase gene gene620 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00621 WSWS_00622 WSWS_00622 WSWS_00622 653054 654376 + hypothetical protein gene gene621 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00622 WSWS_00623 WSWS_00623 WSWS_00623 654376 655362 + Primosomal protein DnaI gene gene622 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00623 WSWS_00624 WSWS_00624 WSWS_00624 655388 656464 + hypothetical protein gene gene623 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00624 WSWS_00625 WSWS_00625 WSWS_00625 656422 657222 + hypothetical protein gene gene624 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00625 WSWS_00626 WSWS_00626 WSWS_00626 657363 658052 + Response regulator ArlR Member of the two-component regulatory system ArlS/ArlR%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene625 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00626 WSWS_00627 WSWS_00627 WSWS_00627 658070 659545 + Signal transduction histidine-protein kinase ArlS Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion%2C autolysis%2C multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: lpl:lp_1545 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene626 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00627 WSWS_00628 WSWS_00628 WSWS_00628 659643 659975 + Putative thioredoxin-5 Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions%3B Belongs to the thioredoxin family%3B Contains 1 thioredoxin domain gene gene627 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00628 WSWS_00629 WSWS_00629 WSWS_00629 660100 660369 + hypothetical protein gene gene628 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00629 WSWS_00630 WSWS_00630 WSWS_00630 660375 661124 + hypothetical protein gene gene629 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00630 WSWS_00631 WSWS_00631 WSWS_00631 661215 661862 + UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase Is the initiating enzyme for colanic acid (CA) synthesis. Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P)%2C forming a phosphoanhydride bond yielding to glucosyl- pyrophosphoryl-undecaprenol (Glc-PP-C55). Also possesses a weak galactose-1-P transferase activity%3B Belongs to the bacterial sugar transferase family gene gene630 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00631 WSWS_00632 WSWS_00632 WSWS_00632 661995 662180 + 30S ribosomal protein S21 Belongs to the ribosomal protein S21P family gene gene631 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00632 WSWS_00633 WSWS_00633 WSWS_00633 662249 662692 + uncharacterized protein gene gene632 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00633 WSWS_00634 WSWS_00634 WSWS_00634 662809 663819 + PhoH-like protein Belongs to the PhoH family gene gene633 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00634 WSWS_00635 WSWS_00635 WSWS_00635 663832 664311 + Endoribonuclease YbeY Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA%3B Belongs to the endoribonuclease YbeY family gene gene634 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00635 WSWS_00636 WSWS_00636 WSWS_00636 664295 664720 + Undecaprenol kinase Catalyzes the phosphorylation of undecaprenol%2C which is probably the primary physiological substrate. Is also able to phosphorylate diacylglycerol%2C albeit with very low efficiency. May play a role in adaptability to environmental stress conditions such as acid tolerance%2C elevated temperatures and high osmolarity%3B Belongs to the bacterial diacylglycerol kinase family%3B KEGG: lfe:LAF_0839 undecaprenol kinase gene gene635 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00636 WSWS_00637 WSWS_00637 WSWS_00637 664763 665668 + GTPase Era An essential GTPase that binds both GDP and GTP%2C with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Era GTPase family%3B Contains 1 Era-type G (guanine nucleotide-binding) domain%3B Contains 1 KH type-2 domain gene gene636 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00637 WSWS_00638 WSWS_00638 ribF ribF 665831 666772 + Riboflavin kinase Belongs to the RibF family%3B KEGG: lbr:LVIS_1332 riboflavin kinase / FMN adenylyltransferase gene gene637 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00638 WSWS_00639 WSWS_00639 WSWS_00639 666788 668512 + uncharacterized protein Belongs to the NEMF family gene gene638 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00639 WSWS_00640 WSWS_00640 WSWS_00640 668611 669246 + CutC-like protein Belongs to the CutC family gene gene639 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00640 WSWS_00641 WSWS_00641 WSWS_00641 669406 669816 + hypothetical protein gene gene640 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00641 WSWS_00642 WSWS_00642 WSWS_00642 669826 671121 + Phosphodiesterase I By generating PPi%2C plays a role in regulating pyrophosphate levels%2C and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals%2C thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP%2C but can also hydrolyze other nucleoside 5' triphosphates such as GTP%2C CTP%2C TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates%2C and also 3'%2C5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi%2C and the regulation of purinergic signaling. Appears to modulate insulin sensitivity and function%3B Belongs to the nucleotide pyrophosphatase/phosphodiesterase family%3B Contains 2 SMB (somatomedin-B) domains%3B KEGG: hsa:5167 ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 gene gene641 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00642 WSWS_00643 WSWS_00643 WSWS_00643 671255 671386 - hypothetical protein gene gene642 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00643 WSWS_00644 WSWS_00644 WSWS_00644 671452 672318 + Protein DegV Binds long-chain fatty acids%2C such as palmitate%2C and may play a role in lipid transport or fatty acid metabolism%3B Contains 1 DegV domain gene gene643 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00644 WSWS_00645 WSWS_00645 WSWS_00645 672380 673234 + DegV domain-containing protein May bind long-chain fatty acids%2C such as palmitate%2C and may play a role in lipid transport or fatty acid metabolism%3B Contains 1 DegV domain gene gene644 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00645 WSWS_00646 WSWS_00646 WSWS_00646 673336 674232 + hypothetical protein gene gene645 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00646 WSWS_00647 WSWS_00647 WSWS_00647 674232 674837 + uncharacterized protein gene gene646 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00647 WSWS_00648 WSWS_00648 WSWS_00648 674837 675058 + UPF0346 protein Belongs to the UPF0346 family gene gene647 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00648 WSWS_00649 WSWS_00649 WSWS_00649 675214 677079 + hypothetical protein gene gene648 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00649 WSWS_00650 WSWS_00650 WSWS_00650 677153 678043 - Putative alpha/beta hydrolase Belongs to the AB hydrolase 3 family%3B KEGG: samy:DB32_008763 acetyl esterase%3B Carboxylic ester hydrolases gene gene649 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00650 WSWS_00651 WSWS_00651 WSWS_00651 678067 680277 - Beta-glucosidase Belongs to the glycosyl hydrolase 3 family%3B KEGG: lmu:LBLM1_08815 beta-glucosidase gene gene650 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00651 WSWS_00652 WSWS_00652 WSWS_00652 680550 681455 + Triacylglycerol lipase KEGG: rba:RB12482 triacylglycerol lipase gene gene651 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00652 WSWS_00653 WSWS_00653 WSWS_00653 681633 682028 + hypothetical protein gene gene652 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00653 WSWS_00654 WSWS_00654 WSWS_00654 682030 682383 + hypothetical protein gene gene653 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00654 WSWS_00655 WSWS_00655 WSWS_00655 682522 682968 + hypothetical protein gene gene654 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00655 WSWS_00656 WSWS_00656 butA butA 683168 683953 + L-2%2C3-butanediol dehydrogenase Catalyzes the reversible reduction of (S)-acetoin to (S%2CS)-butane-2%2C3-diol (L-BD) in the presence of NADH. To a lesser extent%2C can also catalyze the irreversible reduction of diacetyl to (S)-acetoin. Cannot oxidize meso-BD%2C D-BD%2C 2-butanol%2C 1%2C2- propanediol%2C ethanol%2C acetol%2C 1%2C2-butanediol%2C 1%2C3-butanediol%2C n- butanol%2C and n-propanol. Cannot reduce (R)-acetoin%2C acetol%2C dihydroxyacetone and 2%2C4-pentanedione%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: ebi:EbC_pEb17201130 meso-butanediol dehydrogenase / (S%2CS)-butanediol dehydrogenase / diacetyl reductase%3B With NAD(+) or NADP(+) as acceptor gene gene655 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00656 WSWS_00657 WSWS_00657 WSWS_00657 684397 684846 + hypothetical protein gene gene656 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00657 WSWS_00658 WSWS_00658 WSWS_00658 684839 685474 + Glycine betaine/carnitine transport permease protein GbuB Part of the ABC transporter complex GbuABC involved in glycine betaine uptake. Responsible for the translocation of the substrate across the membrane. Involved%2C with BetL and OpuC%2C in osmoprotection and cryoprotection of Listeria. Can also uptake carnitine when carnitine is abundant in the growth medium%3B Belongs to the binding-protein-dependent transport system permease family%3B Contains 1 ABC transmembrane type-1 domain gene gene657 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00658 WSWS_00659 WSWS_00659 WSWS_00659 685464 686378 + Osmoprotectant-binding protein OsmX Part of the OsmU ABC transporter complex%2C which is involved in the uptake of osmoprotectants such as choline-O- sulfate and glycine betaine%3B Belongs to the OsmX family gene gene658 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00659 WSWS_00660 WSWS_00660 WSWS_00660 686403 687173 + Energy-dependent translational throttle protein EttA A translation factor that gates the progression of the 70S ribosomal inititation complex (IC%2C containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation (By similarity)%3B Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily%3B Contains 2 ABC transporter domains gene gene659 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00660 WSWS_00661 WSWS_00661 WSWS_00661 687166 687792 + Putative ABC transporter permease protein Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene660 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00661 WSWS_00662 WSWS_00662 WSWS_00662 688015 688899 + Mitochondrial GTPase Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)%3B Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily%3B Contains 1 CP-type G (guanine nucleotide-binding) domain gene gene661 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00662 WSWS_00663 WSWS_00663 rnhB rnhB 688886 689641 + Ribonuclease H Endonuclease that specifically degrades the RNA of RNA- DNA hybrids%3B Belongs to the RNase HII family%3B KEGG: afn:Acfer_0475 ribonuclease HII gene gene662 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00663 WSWS_00664 WSWS_00664 WSWS_00664 689697 690569 + Protein smf Belongs to the smf family gene gene663 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00664 WSWS_00665 WSWS_00665 topA topA 690709 692808 + DNA topoisomerase Releases the supercoiling and torsional tension of DNA%2C which is introduced during the DNA replication and transcription%2C by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme%2C resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand%2C thus removing DNA supercoils. Finally%2C in the religation step%2C the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone%3B Belongs to the type IA topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: ldb:Ldb1273 DNA topoisomerase I gene gene664 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00665 WSWS_00666 WSWS_00666 WSWS_00666 692876 693778 + Tyrosine recombinase XerC Site-specific tyrosine recombinase%2C which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids%3B Belongs to the 'phage' integrase family. XerC subfamily gene gene665 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00666 WSWS_00667 WSWS_00667 galM galM 693897 694781 + Aldose 1-epimerase KEGG: ldb:Ldb1268 aldose 1-epimerase gene gene666 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00667 WSWS_00668 WSWS_00668 plsY plsY 694835 695464 - Glycerol-3-phosphate 1-O-acyltransferase Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor%2C but not acyl-CoA or acyl-ACP%3B Belongs to the PlsY family%3B KEGG: wce:WS08_0459 glycerol-3-phosphate acyltransferase PlsY gene gene667 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00668 WSWS_00669 WSWS_00669 gyrB gyrB 695788 697815 + DNA topoisomerase (ATP-hydrolyzing) DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings%2C including catenanes and knotted rings%3B Belongs to the type II topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: dhy:DESAM_20784 DNA gyrase subunit B%3B overlaps another CDS with the same product name gene gene668 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00669 WSWS_00670 WSWS_00670 gyrA gyrA 697815 700280 + DNA topoisomerase (ATP-hydrolyzing) Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule%3B Belongs to the topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily%3B KEGG: pih:UB51_22110 DNA gyrase subunit A%3B overlaps another CDS with the same product name gene gene669 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00670 WSWS_00671 WSWS_00671 WSWS_00671 700353 702131 - Elongation factor Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction%2C by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex%2C thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene670 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00671 WSWS_00672 WSWS_00672 ypsC ypsC 702441 703574 + Putative RNA methyltransferase YpsC Belongs to the methyltransferase superfamily%3B Contains 1 THUMP domain%3B KEGG: bmq:BMQ_1440 putative N6-adenine-specific DNA methylase%3B Methyltransferases gene gene671 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00672 WSWS_00673 WSWS_00673 WSWS_00673 703656 705935 + DNA helicase May process damage occurring in non-replicating regions of DNA to produce recombinational intermediates for sister strand recombinational exchange. Belongs to the helicase family. UvrD subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B Contains 1 uvrD-like helicase C-terminal domain%3B KEGG: cbu:CBU_2054 DNA helicase II / ATP-dependent DNA helicase PcrA gene gene672 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00673 WSWS_00674 WSWS_00674 ligA ligA 705947 707974 + DNA ligase (NAD(+)) DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA%3B Belongs to the NAD-dependent DNA ligase family. LigA subfamily%3B Contains 1 BRCT domain%3B KEGG: eli:ELI_07215 DNA ligase (NAD+) gene gene673 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00674 WSWS_00675 WSWS_00675 WSWS_00675 708016 709212 + putative lipoprotein YerH gene gene674 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00675 WSWS_00676 WSWS_00676 WSWS_00676 709269 709889 + hypothetical protein gene gene675 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00676 WSWS_00677 WSWS_00677 WSWS_00677 709963 710598 + hypothetical protein gene gene676 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00677 WSWS_00678 WSWS_00678 WSWS_00678 710722 712734 + UvrABC system protein The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site%2C the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix%2C facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found%2C the DNA wraps around the other UvrB subunit that will check the other stand for damage%3B Belongs to the UvrB family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B Contains 1 UVR domain gene gene677 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00678 WSWS_00679 WSWS_00679 WSWS_00679 712776 713036 - hypothetical protein gene gene678 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00679 WSWS_00680 WSWS_00680 WSWS_00680 713038 713460 - Protein hit Contains 1 HIT domain gene gene679 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00680 WSWS_00681 WSWS_00681 WSWS_00681 713563 714255 + Cytochrome c bioproteinis ATP-binding export protein CcmA Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochrome%3B once thought to export heme%2C this seems not to be the case%2C but its exact role is uncertain. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. CcmA exporter (TC 3. A. 1. 107) family%3B Contains 1 ABC transporter domain gene gene680 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00681 WSWS_00682 WSWS_00682 WSWS_00682 714261 715331 + hypothetical protein gene gene681 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00682 WSWS_00683 WSWS_00683 trmB trmB 715337 715999 + tRNA (guanine(46)-N(7))-methyltransferase Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family%3B KEGG: wko:WKK_00920 tRNA (guanine-N7-)-methyltransferase gene gene682 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00683 WSWS_00684 WSWS_00684 WSWS_00684 716055 716474 - uncharacterized protein gene gene683 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00684 WSWS_00685 WSWS_00685 WSWS_00685 716610 717533 + Thiamine phosphate synthase KEGG: mst:Msp_0683 thiamine-phosphate pyrophosphorylase gene gene684 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00685 WSWS_00686 WSWS_00686 WSWS_00686 717628 718581 + Putative sugar transferase Nss Part of the accessory SecA2/SecY2 system specifically required to export GspB%2C a serine-rich repeat cell wall protein encoded upstream in the same operon gene gene685 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00686 WSWS_00687 WSWS_00687 WSWS_00687 718892 719881 - hypothetical protein gene gene686 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00687 WSWS_00688 WSWS_00688 WSWS_00688 720367 721623 + putative MFS-type transporter Belongs to the major facilitator superfamily gene gene687 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00688 WSWS_00689 WSWS_00689 lplA lplA 721968 722981 + Lipoate--protein ligase Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes%3B Belongs to the LplA family%3B Contains 1 BPL/LPL catalytic domain%3B KEGG: lla:L64373 lipoate-protein ligase A gene gene688 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00689 WSWS_00690 WSWS_00690 pdhA pdhA 722978 724111 + Pyruvate dehydrogenase (acetyl-transferring) The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1)%2C dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)%3B KEGG: lme:LEUM_0737 pyruvate dehydrogenase E1 component alpha subunit gene gene689 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00690 WSWS_00691 WSWS_00691 pdhB pdhB 724113 725093 + Pyruvate dehydrogenase (acetyl-transferring) Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex%2C that catalyzes the overall conversion of branched-chain alpha-ketoacids to acyl-CoA and CO(2)%3B KEGG: wko:WKK_06340 pyruvate dehydrogenase E1 component beta subunit gene gene690 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00691 WSWS_00692 WSWS_00692 dlaT dlaT 725086 726396 + Dihydrolipoyllysine-residue acetyltransferase The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1)%2C lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)%3B Belongs to the 2-oxoacid dehydrogenase family%3B Contains 1 lipoyl-binding domain%3B KEGG: lla:L0035 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) gene gene691 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00692 WSWS_00693 WSWS_00693 WSWS_00693 726401 727810 + Dihydrolipoyl dehydrogenase Catalyzes the oxidation of dihydrolipoamide to lipoamide. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: lla:L0036 dihydrolipoamide dehydrogenase gene gene692 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00693 WSWS_00694 WSWS_00694 WSWS_00694 727862 727946 + tRNA-Leu tRNA gene693 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00694 WSWS_00695 WSWS_00695 WSWS_00695 727968 728765 + Chloride peroxidase Belongs to the bacterial non-heme bromo- and chloro- peroxidases family%3B KEGG: llm:llmg_1737 non-heme chloroperoxidase gene gene694 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00695 WSWS_00696 WSWS_00696 WSWS_00696 728776 729681 + Putative ring-cleaving dioxygenase MhqE Putative ring-cleavage dioxygenase that may contribute to the degradation of aromatic compounds%3B Belongs to the extradiol ring-cleavage dioxygenase family gene gene695 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00696 WSWS_00697 WSWS_00697 WSWS_00697 729790 730305 + hypothetical protein gene gene696 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00697 WSWS_00698 WSWS_00698 WSWS_00698 730407 731192 - Transcriptional regulator LytR Attenuator role for operon expression%3B Belongs to the LytR/CpsA/Psr regulatory protein family gene gene697 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00698 WSWS_00699 WSWS_00699 WSWS_00699 731203 731316 - hypothetical protein gene gene698 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00699 WSWS_00700 WSWS_00700 WSWS_00700 731647 733401 - hypothetical protein gene gene699 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00700 WSWS_00701 WSWS_00701 WSWS_00701 733757 734512 - NADP-dependent 7-alpha-hydroxysteroid dehydrogenase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: bra:BRADO0018 null%3B With NAD(+) or NADP(+) as acceptor gene gene700 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00701 WSWS_00702 WSWS_00702 WSWS_00702 734789 735124 - hypothetical protein gene gene701 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00702 WSWS_00703 WSWS_00703 WSWS_00703 735190 736458 - putative transporter Probable amino-acid or metabolite transport protein%3B Belongs to the amino acid-polyamine-organocation (APC) superfamily gene gene702 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00703 WSWS_00704 WSWS_00704 WSWS_00704 736699 738552 - hypothetical protein gene gene703 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00704 WSWS_00705 WSWS_00705 bcsA bcsA 738572 740569 - Cellulose synthase (UDP-forming) Bifunctional protein comprised of a catalytic subunit and a regulatory subunit. The catalytic subunit of cellulose synthase polymerizes uridine 5'-diphosphate glucose to cellulose in a processive way. The thick cellulosic mats generated by this enzyme probably provide a specialized protective environment to the bacterium. The regulatory subunit binds bis-(3'-5') cyclic diguanylic acid (c-di-GMP). In the N-terminal sectio%3B belongs to the glycosyltransferase 2 family%3B In the C-terminal sectio%3B belongs to the AcsB/BcsB family%3B Contains 1 PilZ domain%3B KEGG: lec:LGMK_04845 cellulose synthase (UDP-forming) gene gene704 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00705 WSWS_00706 WSWS_00706 WSWS_00706 740575 741654 - Dolichyl-phosphate beta-D-mannosyltransferase KEGG: fnu:FN1094 dolichol-phosphate mannosyltransferase gene gene705 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00706 WSWS_00707 WSWS_00707 WSWS_00707 743135 743356 - hypothetical protein gene gene706 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00707 WSWS_00708 WSWS_00708 WSWS_00708 743353 743469 - hypothetical protein gene gene707 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00708 WSWS_00709 WSWS_00709 WSWS_00709 743527 744195 - Methionine import ATP-binding protein MetN Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Methionine importer (TC 3. A. 1. 24) family%3B Contains 1 ABC transporter domain gene gene708 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00709 WSWS_00710 WSWS_00710 WSWS_00710 744198 745247 - Putative hemin transport system permease protein HrtB Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the ABC-4 integral membrane protein family. HrtB subfamily gene gene709 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00710 WSWS_00711 WSWS_00711 WSWS_00711 745451 746071 - Chemotaxis response regulator protein-glutamate methylesterase Involved in the modulation of the chemotaxis syste%3B catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR%3B Contains 1 cheB-type methylesterase domain%3B Contains 1 response regulatory domain gene gene710 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00711 WSWS_00712 WSWS_00712 ydfH ydfH 746076 747269 - Histidine kinase Member of the two-component regulatory system YdfH/YdfI. May activate YdfI by phosphorylation%3B Contains 1 histidine kinase domain%3B KEGG: lki:LKI_04350 two-component system%2C NarL family%2C sensor histidine kinase YdfH gene gene711 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00712 WSWS_00713 WSWS_00713 WSWS_00713 747343 749454 - Membrane protein YdfJ Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family. MmpL subfamily gene gene712 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00713 WSWS_00714 WSWS_00714 WSWS_00714 749649 750089 - HTH-type transcriptional regulator HmrR Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper%2C it negatively regulates the transcription of actP%3B Contains 1 HTH merR-type DNA-binding domain gene gene713 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00714 WSWS_00715 WSWS_00715 WSWS_00715 750109 750759 - hypothetical protein gene gene714 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00715 WSWS_00716 WSWS_00716 WSWS_00716 750802 752127 - putative MFS-type transporter Belongs to the major facilitator superfamily. EmrB family gene gene715 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00716 WSWS_00717 WSWS_00717 dkgA dkgA 752179 753048 - 2%2C5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming) Aldose reductase with a broad substrate specificity. Reduces the cytotoxic compound methylglyoxal (MG) to acetol and (R)-lactaldehyde under stress conditions. MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation (PubMed:11525399). In pentose-fermenting yeasts%2C aldose reductase catalyzes the reduction of xylose into xylitol. The purified enzyme catalyzes this reaction%2C but the inability of S. cerevisiae to grow on xylose as sole carbon source indicates that the physiological function is more likely methylglyoxal reduction (Probable) (PubMed:11722921)%3B Belongs to the aldo/keto reductase family%3B KEGG: tpk:JO40_07140 2%2C5-diketo-D-gluconate reductase A gene gene716 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00717 WSWS_00718 WSWS_00718 WSWS_00718 753429 753941 + Spermidine/spermine N(1)-acetyltransferase Involved in the protection against polyamine toxicity by regulating their concentration. Also could be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase%2C levansucrase and alkaline phosphatase. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It possesses N1- acetyltransferase activity toward polyamine substrates including spermidine%2C spermine%2C aminopropylcadaverine%2C norspermidine%2C homospermidine%2C N(8)-acetylspermidine%2C diaminopropane and agmatine%3B Contains 1 N-acetyltransferase domain%3B KEGG: gfo:GFO_2080 null%3B Transferring groups other than amino-acyl groups gene gene717 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00718 WSWS_00719 WSWS_00719 WSWS_00719 754021 755304 - hypothetical protein gene gene718 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00719 WSWS_00720 WSWS_00720 WSWS_00720 755288 756061 - hypothetical protein gene gene719 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00720 WSWS_00721 WSWS_00721 WSWS_00721 756082 756576 - hypothetical protein gene gene720 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00721 WSWS_00722 WSWS_00722 frdA frdA 756785 757327 + Fumarate reductase (quinol) Involved in the protection against chromate toxicity. Catalyzes the transfer of three electrons to Cr(6+) producing Cr(3+) and one electron to molecular oxygen. This reaction produces transiently a minimal amount of the toxic Cr(5+) species and reactive oxygen species (ROS). It can also reduce quinones%2C potassium ferricyanide and 2%2C6-dichloroindophenol. The quinone reductase activity may protect against oxidative stress by preventing redox cycling of quinones which would otherwise generate ROS and by maintaining a pool of reduced quinone in the cell that is able to quench ROS directly. It displayed an eightfold preference for NADH over NADPH%3B Belongs to the SsuE family%3B KEGG: smu:SMU_180 fumarate reductase flavoprotein subunit gene gene721 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00722 WSWS_00723 WSWS_00723 pcaC pcaC 757431 757724 - 4-carboxymuconolactone decarboxylase KEGG: llj:LG36_0836 4-carboxymuconolactone decarboxylase gene gene722 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00723 WSWS_00724 WSWS_00724 fabG fabG 757855 758604 - 3-oxoacyl-[acyl-carrier-protein] reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: put:PT7_2679 3-oxoacyl-(acyl-carrier protein) reductase gene gene723 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00724 WSWS_00725 WSWS_00725 WSWS_00725 758608 759018 - 4-carboxymuconolactone decarboxylase KEGG: afd:Alfi_3236 4-carboxymuconolactone decarboxylase%3B overlaps another CDS with the same product name gene gene724 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00725 WSWS_00726 WSWS_00726 WSWS_00726 759015 759344 - 4-carboxymuconolactone decarboxylase KEGG: baci:B1NLA3E_13295 4-carboxymuconolactone decarboxylase%3B overlaps another CDS with the same product name gene gene725 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00726 WSWS_00727 WSWS_00727 WSWS_00727 759430 759858 + HTH-type transcriptional regulator GlnR Represses many genes including the glnRA operon and tnrA during growth with nitrogen excess%3B Contains 1 HTH merR-type DNA-binding domain gene gene726 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00727 WSWS_00728 WSWS_00728 WSWS_00728 759822 759917 - hypothetical protein gene gene727 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00728 WSWS_00729 WSWS_00729 WSWS_00729 759917 761182 - hypothetical protein gene gene728 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00729 WSWS_00730 WSWS_00730 praC praC 761228 761617 - 2-hydroxymuconate tautomerase Belongs to the 4-oxalocrotonate tautomerase family%3B KEGG: mav:MAV_2790 4-oxalocrotonate tautomerase gene gene729 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00730 WSWS_00731 WSWS_00731 fruB fruB 761747 763678 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannose transport. Contains 1 PTS EIIA type-2 domain%3B Contains 1 PTS EIIB type-2 domain%3B Contains 1 PTS EIIC type-2 domain%3B KEGG: esc:Entcl_4044 PTS system%2C fructose-specific IIA component gene gene730 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00731 WSWS_00732 WSWS_00732 pfkB pfkB 763685 764596 - 6-phosphofructokinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: sty:STY3436 6-phosphofructokinase 2 gene gene731 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00732 WSWS_00733 WSWS_00733 WSWS_00733 764593 765351 - HTH-type transcriptional regulator GlpR Transcriptional repressor of genes encoding both fructose and glucose metabolic enzymes such as phosphofructokinase (PFK) or 2-keto-3-deoxy-D-gluconate kinase (KDGK) during growth on glycerol. Required for the glycerol-mediated repression of pfkB- specific transcripts%2C but not needed for the high-levels of the pfkB-specific transcript present when cells are grown on fructose%3B Contains 1 HTH deoR-type DNA-binding domain gene gene732 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00733 WSWS_00734 WSWS_00734 WSWS_00734 765502 766140 - hypothetical protein gene gene733 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00734 WSWS_00735 WSWS_00735 WSWS_00735 766153 767244 - Inner membrane transport permease Belongs to the ABC-2 integral membrane protein family%3B Contains 1 ABC transmembrane type-2 domain gene gene734 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00735 WSWS_00736 WSWS_00736 WSWS_00736 767241 767966 - Spermidine/putrescine import ATP-binding protein PotA Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene735 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00736 WSWS_00737 WSWS_00737 WSWS_00737 768111 769262 - hypothetical protein gene gene736 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00737 WSWS_00738 WSWS_00738 acsL acsL 769249 770778 - Long-chain-fatty-acid--CoA ligase Involved in the degradation of long-chain fatty acids. Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: dbr:Deba_1780 long-chain acyl-CoA synthetase gene gene737 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00738 WSWS_00739 WSWS_00739 WSWS_00739 770869 771837 - Putative aliphatic sulfonates-binding protein Part of a binding-protein-dependent transport system for aliphatic sulfonates. Putative binding protein. Belongs to the bacterial solute-binding protein SsuA/TauA family gene gene738 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00739 WSWS_00740 WSWS_00740 WSWS_00740 771843 772559 - Iron-chelate-transporting ATPase Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Fe(3+) ion importer (TC 3. A. 1. 10) family%3B Contains 1 ABC transporter domain%3B KEGG: xne:XNC1_1303 iron complex transport system ATP-binding protein gene gene739 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00740 WSWS_00741 WSWS_00741 ssuD ssuD 772566 773342 - Alkanesulfonate monooxygenase Part of a binding-protein-dependent transport system for aliphatic sulfonates. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain%3B KEGG: pam:PANA_1376 alkanesulfonate monooxygenase gene gene740 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00741 WSWS_00742 WSWS_00742 matB matB 773339 774874 - Long-chain-fatty-acid--CoA ligase FadD17 Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA)%2C which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: amq:AMETH_0718 malonyl-CoA/methylmalonyl-CoA synthetase%3B Acid--thiol ligases gene gene741 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00742 WSWS_00743 WSWS_00743 mutT mutT 775131 775622 - 8-oxo-dGTP diphosphatase KEGG: lgs:LEGAS_1203 8-oxo-dGTP diphosphatase gene gene742 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00743 WSWS_00744 WSWS_00744 WSWS_00744 775740 775913 - hypothetical protein gene gene743 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00744 WSWS_00745 WSWS_00745 dtd1 dtd1 776122 776571 - D-aminoacyl-tRNA deacylase D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules%2C this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo%3B Belongs to the DTD family%3B KEGG: bmx:BMS_2312 D-tyrosyl-tRNA(Tyr) deacylase%3B Acting on ester bonds gene gene744 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00745 WSWS_00746 WSWS_00746 relA relA 776632 778857 - GTP diphosphokinase In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity)%3B Belongs to the RelA/SpoT family%3B Contains 1 ACT domain%3B Contains 1 HD domain%3B KEGG: ooe:OEOE_0587 GTP pyrophosphokinase gene gene745 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00746 WSWS_00747 WSWS_00747 WSWS_00747 779110 780243 - RNA polymerase sigma factor SigA Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth%3B Belongs to the sigma-70 factor family. RpoD/SigA subfamily gene gene746 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00747 WSWS_00748 WSWS_00748 dnaG dnaG 780267 782171 - DNA primase RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication%3B Belongs to the DnaG primase family%3B Contains 1 Toprim domain%3B KEGG: pln:Plano_1286 DNA primase%3B Nucleotidyltransferases gene gene747 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00748 WSWS_00749 WSWS_00749 WSWS_00749 782394 782492 - hypothetical protein gene gene748 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00749 WSWS_00750 WSWS_00750 ncd2 ncd2 782572 783507 - Nitronate monooxygenase Catalyzes the oxidation of alkyl nitronates to produce the corresponding carbonyl compounds and nitrites%3B Belongs to the nitronate monooxygenase family%3B KEGG: cbw:RR42_s3251 nitronate monooxygenase gene gene749 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00750 WSWS_00751 WSWS_00751 WSWS_00751 783539 785098 - Propionate CoA-transferase CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Exhibits high activity with acetoacetyl-CoA%2C propionyl-CoA%2C crotonoyl-CoA or butyryl-CoA as donors%2C with acetate as an acceptor. When acetyl-CoA is used as the donor%2C propionate%2C acetoacetate%2C butyrate%2C isobutyrate%2C and 4-hydroxybutyrate can be utilized as acceptors but not isovalerate. May play a role in short-chain fatty acid metabolism in E. coli%3B Belongs to the 3-oxoacid CoA-transferase family%3B KEGG: lmo:lmo2172 propionate CoA-transferase gene gene750 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00751 WSWS_00752 WSWS_00752 WSWS_00752 785259 786149 + putative HTH-type transcriptional regulator YhjC Contains 1 HTH lysR-type DNA-binding domain gene gene751 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00752 WSWS_00753 WSWS_00753 WSWS_00753 786260 787876 - Lipid A export ATP-binding/permease protein MsbA Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation%3B Belongs to the ABC transporter superfamily. Lipid exporter (TC 3. A. 1. 106) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene752 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00753 WSWS_00754 WSWS_00754 WSWS_00754 788174 789625 - Putative permease IIC component YwbA The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane%3B Contains 1 PTS EIIC type-3 domain gene gene753 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00754 WSWS_00755 WSWS_00755 WSWS_00755 789625 791007 - 6-phospho-beta-glucosidase Belongs to the glycosyl hydrolase 1 family%3B KEGG: lrm:LRC_02230 6-phospho-beta-glucosidase gene gene754 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00755 WSWS_00756 WSWS_00756 WSWS_00756 791282 791992 + HTH-type transcriptional regulator GmuR Transcriptional repressor of the gmuBACDREFG operon which is involved in the uptake and degradation of glucomannan%3B Contains 1 HTH gntR-type DNA-binding domain gene gene755 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00756 WSWS_00757 WSWS_00757 WSWS_00757 792053 793411 - Glucose-6-phosphate isomerase Belongs to the GPI family%3B KEGG: lpl:lp_2502 glucose-6-phosphate isomerase gene gene756 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00757 WSWS_00758 WSWS_00758 hxlB hxlB 793395 793928 - 6-phospho-3-hexuloisomerase Catalyzes the isomerization between 3-hexulose 6- phosphate and fructose 6-phosphate%3B Belongs to the SIS family. PHI subfamily%3B Contains 1 SIS domain%3B KEGG: lmm:MI1_09736 6-phospho-3-hexuloisomerase gene gene757 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00758 WSWS_00759 WSWS_00759 hxlA hxlA 793953 794579 - 3-hexulose-6-phosphate synthase Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate%3B Belongs to the HPS/KGPDC family. HPS subfamily%3B KEGG: eum:ECUMN_2963 3-hexulose-6-phosphate synthase gene gene758 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00759 WSWS_00760 WSWS_00760 WSWS_00760 794703 795086 + HTH-type transcriptional activator HxlR Positive regulator of hxlAB expression. Contains 1 HTH hxlR-type DNA-binding domain gene gene759 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00760 WSWS_00761 WSWS_00761 WSWS_00761 795198 795650 - hypothetical protein gene gene760 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00761 WSWS_00762 WSWS_00762 hsdS hsdS 795906 797003 - Type I site-specific deoxyribonuclease KEGG: fpp:FPB0191_02175 type I restriction enzyme%2C S subunit gene gene761 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00762 WSWS_00763 WSWS_00763 hsdM hsdM 796996 798591 - Site-specific DNA-methyltransferase (adenine-specific) Methylation of specific adenine residue%3B required for both restriction and modification activities (By similarity). The EcoR124/3 I enzyme recognizes 5'-GAAN(7)RTCG-3'%3B Belongs to the N(4)/N(6)-methyltransferase family%3B KEGG: llt:CVCAS_pB0004 type I restriction enzyme M protein gene gene762 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00763 WSWS_00764 WSWS_00764 hsdR hsdR 798591 801668 - Type I site-specific deoxyribonuclease Subunit R is required for both nuclease and ATPase activities%2C but not for modification%3B Belongs to the HsdR family%3B Contains 1 helicase ATP-binding domain%3B KEGG: lgs:LEGAS_0979 type I restriction enzyme%2C R subunit gene gene763 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00764 WSWS_00765 WSWS_00765 WSWS_00765 802050 802556 - Elongation factor Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction%2C by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex%2C thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain%3B overlaps another CDS with the same product name gene gene764 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00765 WSWS_00766 WSWS_00766 WSWS_00766 802553 803851 - Elongation factor Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step%2C the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites%2C respectively. Catalyzes the coordinated movement of the two tRNA molecules%2C the mRNA and conformational changes in the ribosome%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain%3B overlaps another CDS with the same product name gene gene765 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00766 WSWS_00767 WSWS_00767 WSWS_00767 804043 805722 - Xylan 1%2C4-beta-xylosidase Alpha-L-arabinofuranosidase involved in xyloglucan degradation by mediating the cleavage of terminal non-reducing alpha-L-arabinofuranoside residues in xyloglucan branches%2C converting the 'S' units to 'X' units%3B Belongs to the glycosyl hydrolase 43 family%3B KEGG: gap:GAPWK_2564 xylan 1%2C4-beta-xylosidase gene gene766 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00767 WSWS_00768 WSWS_00768 WSWS_00768 805753 806901 - Glucan 1%2C3-beta-glucosidase Beta-glucanases participate in the metabolism of beta- glucan%2C the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase (By similarity)%3B Belongs to the glycosyl hydrolase 5 (cellulase A) family%3B KEGG: mph:MLP_07030 glucan 1%2C3-beta-glucosidase gene gene767 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00768 WSWS_00769 WSWS_00769 WSWS_00769 806913 808157 - hypothetical protein gene gene768 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00769 WSWS_00770 WSWS_00770 bgaB bgaB 808154 810181 - Beta-galactosidase May play a role in the degradation of rhamnogalacturonan derived from plant cell walls%3B Belongs to the glycosyl hydrolase 42 family%3B KEGG: shg:Sph21_2648 beta-galactosidase gene gene769 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00770 WSWS_00771 WSWS_00771 WSWS_00771 810306 811205 + putative HTH-type transcriptional regulator YobQ Contains 1 HTH araC/xylS-type DNA-binding domain gene gene770 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00771 WSWS_00772 WSWS_00772 WSWS_00772 811344 811760 - hypothetical protein gene gene771 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00772 WSWS_00773 WSWS_00773 WSWS_00773 811771 812517 - hypothetical protein gene gene772 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00773 WSWS_00774 WSWS_00774 hipO hipO 812525 813715 - Hippurate hydrolase Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate%3B Belongs to the peptidase M20A family. N- acetyldiaminopimelate deacetylase subfamily%3B KEGG: byi:BYI23_B013260 hippurate hydrolase gene gene773 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00774 WSWS_00775 WSWS_00775 pgmB pgmB 813842 814516 - Beta-phosphoglucomutase Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P)%2C and forming beta-D-glucose 1%2C6-(bis)phosphate (beta-G16P) as an intermediate. The beta- phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose (By similarity)%3B Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family%3B KEGG: lre:Lreu_0055 beta-phosphoglucomutase gene gene774 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00775 WSWS_00776 WSWS_00776 mapA mapA 814518 816776 - Maltose phosphorylase Catalyzes the phosphorolysis of maltose%2C leading to the formation of glucose and glucose 1-P. Does not have maltose 6'-P phosphorylase activity. Plays an important role in the metabolism of maltose taken up via the bacterial phosphotransferase system (PTS)%3B Belongs to the glycosyl hydrolase 65 family%3B KEGG: bck:BCO26_0523 maltose phosphorylase gene gene775 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00776 WSWS_00777 WSWS_00777 WSWS_00777 816792 818549 - Cyclomaltodextrinase Hydrolyzes pullulan efficiently but only a small amount of starch. Endohydrolysis of 1%2C4-alpha-glucosidic linkages in pullulan to form panose. Cleaves also (1-6)-alpha-glucosidic linkages to form maltotriose. Belongs to the glycosyl hydrolase 13 family%3B KEGG: lsl:LSL_1295 cyclomaltodextrinase gene gene776 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00777 WSWS_00778 WSWS_00778 WSWS_00778 818696 820048 - hypothetical protein gene gene777 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00778 WSWS_00779 WSWS_00779 WSWS_00779 820319 821257 + putative HTH-type transcriptional repressor ExuR Transcriptional repressor for the exu locus which is required for galacturonate utilization%3B Contains 1 HTH lacI-type DNA-binding domain gene gene778 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00779 WSWS_00780 WSWS_00780 WSWS_00780 821300 822793 - Inner membrane transporter Belongs to the amino acid-polyamine-organocation (APC) superfamily gene gene779 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00780 WSWS_00781 WSWS_00781 WSWS_00781 822967 823449 - 8-oxo-dGTP diphosphatase KEGG: apo:Arcpr_0804 8-oxo-dGTP diphosphatase gene gene780 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00781 WSWS_00782 WSWS_00782 WSWS_00782 823618 824037 - hypothetical protein gene gene781 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00782 WSWS_00783 WSWS_00783 WSWS_00783 824207 825925 - Glycine betaine/carnitine transport permease protein GbuB Part of the ABC transporter complex GbuABC involved in glycine betaine uptake. Responsible for the translocation of the substrate across the membrane. Involved%2C with BetL and OpuC%2C in osmoprotection and cryoprotection of Listeria. Can also uptake carnitine when carnitine is abundant in the growth medium%3B Belongs to the binding-protein-dependent transport system permease family%3B Contains 1 ABC transmembrane type-1 domain gene gene782 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00783 WSWS_00784 WSWS_00784 proV proV 825928 827115 - Quaternary-amine-transporting ATPase Involved in a multicomponent binding-protein-dependent transport system for glycine betaine. Probably responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B Contains 2 CBS domains%3B KEGG: lbh:Lbuc_1681 glycine betaine/proline transport system ATP-binding protein gene gene783 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00784 WSWS_00785 WSWS_00785 WSWS_00785 827391 828011 + hypothetical protein gene gene784 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00785 WSWS_00786 WSWS_00786 WSWS_00786 828067 828657 - putative GTP-binding protein EngB Necessary for normal cell division and for the maintenance of normal septation%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngB GTPase family%3B Contains 1 EngB-type G (guanine nucleotide-binding) domain gene gene785 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00786 WSWS_00787 WSWS_00787 WSWS_00787 828670 829914 - ATP-dependent Clp protease ATP-binding subunit ClpX ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP%3B Belongs to the ClpX chaperone family gene gene786 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00787 WSWS_00788 WSWS_00788 WSWS_00788 830043 831341 - Trigger factor Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase%3B Belongs to the FKBP-type PPIase family. Tig subfamily%3B Contains 1 PPIase FKBP-type domain gene gene787 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00788 WSWS_00789 WSWS_00789 WSWS_00789 831503 833023 - Phosphoenolpyruvate carboxylase Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA)%2C a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle%3B Belongs to the PEPCase type 2 family%3B KEGG: lfc:LFE_2373 phosphoenolpyruvate carboxylase gene gene788 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00789 WSWS_00790 WSWS_00790 WSWS_00790 833221 834408 - Elongation factor Tu This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene789 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00790 WSWS_00791 WSWS_00791 WSWS_00791 834634 835527 - hypothetical protein gene gene790 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00791 WSWS_00792 WSWS_00792 WSWS_00792 835594 837465 - Ribonuclease J An RNase that has 5'-3' exonuclease and possibly endoonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay (By similarity)%3B Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily%3B KEGG: soi:I872_09290 ribonuclease J%3B Acting on ester bonds gene gene791 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00792 WSWS_00793 WSWS_00793 apeH apeH 837654 839522 - Acylaminoacyl-peptidase Belongs to the peptidase S9B family%3B KEGG: gka:GK0961 acylaminoacyl-peptidase gene gene792 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00793 WSWS_00794 WSWS_00794 WSWS_00794 839634 839888 - 30S ribosomal protein S20 Binds directly to 16S ribosomal RNA%3B Belongs to the ribosomal protein S20P family gene gene793 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00794 WSWS_00795 WSWS_00795 WSWS_00795 839943 840212 - 30S ribosomal protein S15 One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA%3B Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome%3B Belongs to the ribosomal protein S15P family gene gene794 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00795 WSWS_00796 WSWS_00796 holA holA 840351 841367 - DNA-directed DNA polymerase KEGG: drm:Dred_2506 DNA polymerase III subunit delta gene gene795 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00796 WSWS_00797 WSWS_00797 WSWS_00797 841336 843573 - ComE operon protein The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding. To H. influenzae REC2%2C N. gonorrhoeae ComA and E. coli YcaI%3B overlaps another CDS with the same product name gene gene796 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00797 WSWS_00798 WSWS_00798 WSWS_00798 843570 844277 - ComE operon protein Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect. Contains 2 HhH domains%3B overlaps another CDS with the same product name gene gene797 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00798 WSWS_00799 WSWS_00799 WSWS_00799 844340 845608 - TPR repeat-containing protein YpiA Contains 9 TPR repeats gene gene798 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00799 WSWS_00800 WSWS_00800 WSWS_00800 845689 845826 - hypothetical protein gene gene799 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00800 WSWS_00801 WSWS_00801 WSWS_00801 845807 846454 - hypothetical protein gene gene800 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00801 WSWS_00802 WSWS_00802 WSWS_00802 846596 847729 - hypothetical protein gene gene801 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00802 WSWS_00803 WSWS_00803 WSWS_00803 847747 849261 - hypothetical protein gene gene802 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00803 WSWS_00804 WSWS_00804 WSWS_00804 849444 852098 - CDP-glycerol glycerophosphotransferase KEGG: exm:U719_14040 CDP-glycerol glycerophosphotransferase gene gene803 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00804 WSWS_00805 WSWS_00805 WSWS_00805 852279 854135 - Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase KEGG: lbr:LVIS_1883 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase gene gene804 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00805 WSWS_00806 WSWS_00806 cwlA cwlA 854159 856099 - N-acetylmuramoyl-L-alanine amidase Is the major glucosaminidase responsible for peptidoglycan structural determination during vegetative growth. Acts processively from the ends of the glycan strands. Also plays a role in motility%2C chemotaxis and cell division%3B Belongs to the glycosyl hydrolase 73 family%3B KEGG: ppe:PEPE_0453 N-acetylmuramoyl-L-alanine amidase gene gene805 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00806 WSWS_00807 WSWS_00807 WSWS_00807 856126 856665 - hypothetical protein gene gene806 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00807 WSWS_00808 WSWS_00808 WSWS_00808 856974 857747 - hypothetical protein gene gene807 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00808 WSWS_00809 WSWS_00809 WSWS_00809 857824 859038 - Multidrug resistance protein MdtG Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2. A. 1. 2. 20) subfamily gene gene808 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00809 WSWS_00810 WSWS_00810 WSWS_00810 859301 860590 + Alpha-ketoglutarate permease Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system)%3B Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family gene gene809 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00810 WSWS_00811 WSWS_00811 WSWS_00811 860635 861462 - Peptidoglycan DL-endopeptidase CwlO Shows a cell wall hydrolytic DL-endopeptidase activity%3B Belongs to the peptidase C40 family gene gene810 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00811 WSWS_00812 WSWS_00812 dsdA dsdA 861629 862927 + D-serine ammonia-lyase Belongs to the serine/threonine dehydratase family. DsdA subfamily%3B KEGG: pce:PECL_124 D-serine dehydratase gene gene811 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00812 WSWS_00813 WSWS_00813 WSWS_00813 862984 863655 - Xaa-Pro dipeptidase Belongs to the IMPACT family%3B KEGG: sph:MGAS10270_Spy1444 Xaa-Pro dipeptidase gene gene812 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00813 WSWS_00814 WSWS_00814 WSWS_00814 863732 865411 - Ribonuclease J1 An RNase that has endonuclease and 5'-3' exonuclease activity%2C playing a role in both rRNA and mRNA stability and degradation. Endonuclease activity can cleave within 4 nucleotides of the 5'-end of a triphosphorylated RNA. Endonuclease digestion by the RNase J1/J2 complex occurs at a different site and in some cases more efficiently than J1 or J2 alone. The exonuclease activity of the J1/J2 complex is highly processive on substrates longer than 5 nucleotides%2C on shorter substrates is distributive. Preferentially cleaves ssRNA%2C possibly in AU-rich regions. The 5'- exonuclease activity acts on 5'-hydroxyl and 5'-monophosphate but not 5'-triphosphate end%3B it can digest through stem-loop structures if they are not too stable. Required for maturation of 16S rRNA. Acts preferentially on 16S rRNA precursors after association of the 30S and 50S ribosomal subunits. Plays a role in the secondary pathway of 23S rRNA 5' end maturation. Probably also participates in processing of pre-scRNA (the precursor of the signal recognition particle RNA)%3B Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily%3B KEGG: sag:SAG1761 ribonuclease J%3B Acting on ester bonds gene gene813 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00814 WSWS_00815 WSWS_00815 WSWS_00815 865424 865663 - UPF0356 protein Belongs to the UPF0356 family gene gene814 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00815 WSWS_00816 WSWS_00816 WSWS_00816 865847 865918 - tRNA-Gly tRNA gene815 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00816 WSWS_00817 WSWS_00817 WSWS_00817 865951 866022 - tRNA-Gly tRNA gene816 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00817 WSWS_00818 WSWS_00818 dkgB dkgB 866143 866976 + 2%2C5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming) Mediates the reduction of D-galacturonate to L- galactonate%2C the first step in D-galacturonate catabolic process. Also has activity with D-glucuronate and DL-glyceraldehyde. No activity is observed with D-glucose%2C D-fructose%2C D-xylose%2C D- galactose%2C L-arabinose or D-mannose. Activity is seen only with NADPH and not with NADH%3B Belongs to the aldo/keto reductase family%3B KEGG: bcen:DM39_6494 2%2C5-diketo-D-gluconate reductase B gene gene817 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00818 WSWS_00819 WSWS_00819 WSWS_00819 867034 867258 - UPF0154 protein Belongs to the UPF0154 family gene gene818 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00819 WSWS_00820 WSWS_00820 WSWS_00820 867429 867683 - UPF0291 protein Belongs to the UPF0291 family gene gene819 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00820 WSWS_00821 WSWS_00821 lexA lexA 867832 868452 + Repressor LexA Represses a number of genes involved in the response to DNA damage (SOS response)%2C including recA and lexA. In the presence of single-stranded DNA%2C RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA%2C leading to derepression of the SOS regulon and eventually DNA repair%3B Belongs to the peptidase S24 family%3B KEGG: lfc:LFE_1686 repressor LexA gene gene820 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00821 WSWS_00822 WSWS_00822 WSWS_00822 868491 869132 - hypothetical protein gene gene821 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00822 WSWS_00823 WSWS_00823 pepT pepT 869194 870429 - Tripeptide aminopeptidase Cleaves the N-terminal amino acid of tripeptides%3B Belongs to the peptidase M20B family%3B KEGG: wko:WKK_00330 tripeptide aminopeptidase gene gene822 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00823 WSWS_00824 WSWS_00824 WSWS_00824 870445 871245 - GTP cyclohydrolase 1 type 2 like protein Belongs to the GTP cyclohydrolase I type 2/NIF3 family gene gene823 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00824 WSWS_00825 WSWS_00825 trmK trmK 871242 871931 - tRNA (adenine(22)-N(1))-methyltransferase Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 22 (m1A22) in tRNA%3B Belongs to the TrmK family%3B KEGG: lme:LEUM_0770 tRNA (adenine22-N1)-methyltransferase gene gene824 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00825 WSWS_00826 WSWS_00826 WSWS_00826 872109 873059 + Diacylglycerol kinase (ATP) Probably phosphorylates lipid%3B the in vivo substrate is unknown%3B Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily%3B Contains 1 DAGKc domain%3B KEGG: svi:Svir_21940 diacylglycerol kinase (ATP) gene gene825 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00826 WSWS_00827 WSWS_00827 WSWS_00827 873146 875005 - Oligopeptide-binding protein OppA This protein is a component of the oligopeptide permease%2C a binding protein-dependent transport system%2C it binds peptides up to five amino acids long with high affinity. Belongs to the bacterial solute-binding protein 5 family gene gene826 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00827 WSWS_00828 WSWS_00828 WSWS_00828 875313 876209 - Oligopeptide transport system permease protein Part of the binding-protein-dependent transport system for oligopeptide%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene827 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00828 WSWS_00829 WSWS_00829 WSWS_00829 876220 877185 - Oligopeptide transport system permease protein OppB Part of the binding-protein-dependent transport system for oligopeptide%3B probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene828 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00829 WSWS_00830 WSWS_00830 WSWS_00830 877189 878184 - putative ABC transporter ATP-binding protein Belongs to the ABC transporter superfamily%3B Contains 2 ABC transporter domains gene gene829 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00830 WSWS_00831 WSWS_00831 WSWS_00831 878181 879194 - Oligopeptide transport ATP-binding protein OppD Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene830 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00831 WSWS_00832 WSWS_00832 WSWS_00832 879392 879922 - Peptide-methionine (S)-S-oxide reductase Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine%3B Belongs to the MsrA Met sulfoxide reductase family%3B KEGG: pao:Pat9b_5865 peptide-methionine (S)-S-oxide reductase gene gene831 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00832 WSWS_00833 WSWS_00833 WSWS_00833 879975 880811 - putative D-methionine-binding lipoprotein MetQ This protein is a component of a D-methionine permease%2C a binding protein-dependent%2C ATP-driven transport system%3B Belongs to the NlpA lipoprotein family gene gene832 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00833 WSWS_00834 WSWS_00834 ppaC ppaC 881259 882179 - Inorganic diphosphatase Belongs to the PPase class C family%3B KEGG: pce:PECL_934 manganese-dependent inorganic pyrophosphatase gene gene833 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00834 WSWS_00835 WSWS_00835 WSWS_00835 882394 882663 - 30S ribosomal protein S14 Binds 16S rRNA%2C required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site%3B Belongs to the ribosomal protein S14P family gene gene834 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00835 WSWS_00836 WSWS_00836 WSWS_00836 882666 882887 - 50S ribosomal protein L33 Belongs to the ribosomal protein L33P family gene gene835 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00836 WSWS_00837 WSWS_00837 WSWS_00837 883147 883695 - Ribosome-recycling factor Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another%3B Belongs to the RRF family gene gene836 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00837 WSWS_00838 WSWS_00838 pyrH pyrH 883698 884420 - UMP kinase Catalyzes the reversible phosphorylation of UMP to UDP%3B Belongs to the UMP kinase family%3B KEGG: gur:Gura_3731 uridylate kinase gene gene837 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00838 WSWS_00839 WSWS_00839 WSWS_00839 884448 885326 - Elongation factor Ts Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA. EF- Tu. GTP complex up to the GTP hydrolysis stage on the ribosome%3B Belongs to the EF-Ts family gene gene838 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00839 WSWS_00840 WSWS_00840 WSWS_00840 885426 886586 - hypothetical protein gene gene839 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00840 WSWS_00841 WSWS_00841 WSWS_00841 886724 887503 - 30S ribosomal protein S2 Belongs to the ribosomal protein S2P family gene gene840 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00841 WSWS_00842 WSWS_00842 WSWS_00842 887664 887957 - UPF0213 protein Belongs to the UPF0213 family%3B Contains 1 GIY-YIG domain gene gene841 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00842 WSWS_00843 WSWS_00843 WSWS_00843 887950 888708 - uncharacterized protein gene gene842 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00843 WSWS_00844 WSWS_00844 plsC plsC 888857 889492 + 1-acylglycerol-3-phosphate O-acyltransferase Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) by incorporating an acyl moiety at the 2 position. This enzyme utilizes acyl-ACP as fatty acyl donor%2C but not acyl-CoA%3B Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family%3B KEGG: lsa:LSA1268 1-acyl-sn-glycerol-3-phosphate acyltransferase gene gene843 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00844 WSWS_00845 WSWS_00845 WSWS_00845 889581 890891 - GTPase Obg An essential GTPase which binds GTP%2C GDP and possibly (p)ppGpp with moderate affinity%2C with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle%2C stress response%2C ribosome biogenesis and in those bacteria that undergo differentiation%2C in morphogenesis control%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family%3B Contains 1 OBG-type G (guanine nucleotide-binding) domain gene gene844 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00845 WSWS_00846 WSWS_00846 WSWS_00846 891028 892821 - UvrABC system protein The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision%3B Belongs to the UvrC family%3B Contains 1 GIY-YIG domain%3B Contains 1 UVR domain gene gene845 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00846 WSWS_00847 WSWS_00847 WSWS_00847 892838 893344 - hypothetical protein gene gene846 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00847 WSWS_00848 WSWS_00848 WSWS_00848 893553 894287 - Phosphonates import ATP-binding protein Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3. A. 1. 9. 1) family%3B Contains 1 ABC transporter domain%3B KEGG: eco:b1858 zinc transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene847 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00848 WSWS_00849 WSWS_00849 WSWS_00849 894455 894595 + hypothetical protein gene gene848 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00849 WSWS_00850 WSWS_00850 WSWS_00850 894648 894932 - hypothetical protein gene gene849 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00850 WSWS_00851 WSWS_00851 WSWS_00851 894948 897575 - DNA translocase FtsK Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site%2C which is located within the replication terminus region. Required for activation of the Xer recombinase%2C allowing activation of chromosome unlinking by recombination (By similarity)%3B Belongs to the FtsK/SpoIIIE/SftA family%3B Contains 1 FtsK domain gene gene850 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00851 WSWS_00852 WSWS_00852 trmL trmL 897594 898109 - tRNA (cytidine(34)-2'-O)-methyltransferase Could methylate the ribose at the nucleotide 34 wobble position in tRNA%3B Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily%3B KEGG: spr:spr0432 tRNA (cytidine/uridine-2'-O-)-methyltransferase gene gene851 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00852 WSWS_00853 WSWS_00853 WSWS_00853 898250 899440 - UPF0118 membrane protein YueF Belongs to the UPF0118 (PerM) family gene gene852 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00853 WSWS_00854 WSWS_00854 WSWS_00854 899523 900545 - 6-phosphogluconolactonase Belongs to the cycloisomerase 2 family%3B KEGG: lpl:lp_2219 6-phosphogluconolactonase gene gene853 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00854 WSWS_00855 WSWS_00855 WSWS_00855 900665 901186 - uncharacterized protein gene gene854 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00855 WSWS_00856 WSWS_00856 patA patA 901322 902509 - Putative N-acetyl-LL-diaminopimelate aminotransferase May catalyze the conversion of L-2-acetamido-6- oxopimelate to N-acetyl-LL-2%2C6-diaminopimelate%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: lsn:LSA_08580 aminotransferase%3B Transaminases gene gene855 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00856 WSWS_00857 WSWS_00857 WSWS_00857 902621 903724 - Aspartate-semialdehyde dehydrogenase Belongs to the aspartate-semialdehyde dehydrogenase family%3B KEGG: cbu:CBU_0875 aspartate-semialdehyde dehydrogenase gene gene856 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00857 WSWS_00858 WSWS_00858 dapB dapB 903748 904488 - 4-hydroxy-tetrahydrodipicolinate reductase Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate%3B Belongs to the DapB family%3B KEGG: lme:LEUM_0671 4-hydroxy-tetrahydrodipicolinate reductase gene gene857 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00858 WSWS_00859 WSWS_00859 dapA dapA 904488 905360 - 4-hydroxy-tetrahydrodipicolinate synthase Catalyzes the condensation of (S)-aspartate-beta- semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)%3B Belongs to the DapA family%3B KEGG: ppe:PEPE_0133 4-hydroxy-tetrahydrodipicolinate synthase gene gene858 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00859 WSWS_00860 WSWS_00860 WSWS_00860 905362 906513 - N-acetyldiaminopimelate deacetylase Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate%3B Belongs to the peptidase M20A family. N- acetyldiaminopimelate deacetylase subfamily%3B KEGG: lai:LAC30SC_04285 N-acetyldiaminopimelate deacetylase gene gene859 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00860 WSWS_00861 WSWS_00861 dapH dapH 906524 907231 - Tetrahydrodipicolinate N-acetyltransferase Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate%3B Belongs to the transferase hexapeptide repeat family. DapH subfamily%3B KEGG: lde:LDBND_1031 tetrahydrodipicolinate N-acetyltransferase gene gene860 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00861 WSWS_00862 WSWS_00862 lysA lysA 907259 908545 - Diaminopimelate decarboxylase Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity). Plays a role in beta-lactam antibiotic resistance%3B Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily%3B KEGG: lsp:Bsph_1716 diaminopimelate decarboxylase gene gene861 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00862 WSWS_00863 WSWS_00863 WSWS_00863 908563 909579 - Alanine racemase Catalyzes the interconversion of D-lysine and L-lysine. Can also use arginine and ornithine%2C but not alanine%3B Belongs to the alanine racemase family%3B KEGG: aac:Aaci_0357 alanine racemase gene gene862 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00863 WSWS_00864 WSWS_00864 lysC lysC 910080 911435 + Aspartate kinase Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate%2C which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine%2C isoleucine and methionine%3B Belongs to the aspartokinase family%3B Contains 2 ACT domains%3B KEGG: bsu:BSU03790 aspartate kinase gene gene863 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00864 WSWS_00865 WSWS_00865 WSWS_00865 911750 912694 + Alcohol dehydrogenase Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily%3B KEGG: efa:EF0111 alcohol dehydrogenase gene gene864 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00865 WSWS_00866 WSWS_00866 WSWS_00866 912765 913133 + hypothetical protein gene gene865 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00866 WSWS_00867 WSWS_00867 WSWS_00867 913200 913541 + UPF0145 protein Belongs to the UPF0145 family gene gene866 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00867 WSWS_00868 WSWS_00868 WSWS_00868 914441 914692 - hypothetical protein gene gene867 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00868 WSWS_00869 WSWS_00869 WSWS_00869 914707 915159 - hypothetical protein gene gene868 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00869 WSWS_00870 WSWS_00870 WSWS_00870 915393 915476 - tRNA-Leu tRNA gene869 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00870 WSWS_00871 WSWS_00871 WSWS_00871 915537 916274 - hypothetical protein gene gene870 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00871 WSWS_00872 WSWS_00872 WSWS_00872 916267 916476 - hypothetical protein gene gene871 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00872 WSWS_00873 WSWS_00873 WSWS_00873 916473 917321 - Phosphoglycolate phosphatase Catalyzes the dephosphorylation of 2-phosphoglycolate%3B Belongs to the archaeal SPP-like hydrolase family gene gene872 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00873 WSWS_00874 WSWS_00874 WSWS_00874 917443 917844 + Large-conductance mechanosensitive channel Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell%3B Belongs to the MscL family gene gene873 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00874 WSWS_00875 WSWS_00875 WSWS_00875 918074 918718 + Deoxyadenosine kinase Plays an essential role in generating the deoxyribonucleotide precursors dATP AND dCTP for DNA metabolism. The phosphate acceptor specificity is strict toward deoxyadenosine (dAdo) and deoxycytidine (dCyd). The specificity toward the sugar moiety of the nucleoside is less strict. Both 2-deoxyribose%2C ribose%2C and arabinose nucleosides are phosphorylated%2C although the 2-deoxyribonucleosides are preferred. The phosphate donor specificity is dependent on the deoxyribonucleoside substrate%2C but GTP is efficient with both deoxycytidine and deoxyadenosine. Only nucleoside triphosphates can act as phosphate donors%3B Belongs to the DCK/DGK family%3B KEGG: blr:BRLA_c014730 deoxyadenosine/deoxycytidine kinase gene gene874 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00875 WSWS_00876 WSWS_00876 WSWS_00876 918778 920163 - Serine-rich adhesin for platelets Mediates binding to human platelets%2C possibly through a receptor-ligand interaction%3B Belongs to the SraP family gene gene875 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00876 WSWS_00877 WSWS_00877 WSWS_00877 920465 921976 - Glycerol kinase Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate%3B Belongs to the FGGY kinase family%3B KEGG: aap:NT05HA_0711 glycerol kinase gene gene876 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00877 WSWS_00878 WSWS_00878 WSWS_00878 922088 922273 - 2-hydroxymuconate tautomerase Belongs to the 4-oxalocrotonate tautomerase family%3B KEGG: lla:L168282 4-oxalocrotonate tautomerase gene gene877 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00878 WSWS_00879 WSWS_00879 WSWS_00879 922356 923282 - UPF0750 membrane protein YqfU Belongs to the UPF0750 family gene gene878 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00879 WSWS_00880 WSWS_00880 WSWS_00880 923435 923791 - 50S ribosomal protein L19 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site%3B Belongs to the ribosomal protein L19P family gene gene879 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00880 WSWS_00881 WSWS_00881 WSWS_00881 923917 924528 - hypothetical protein gene gene880 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00881 WSWS_00882 WSWS_00882 WSWS_00882 924775 925911 - Protein RecA It interacts with LexA causing its activation and leading to its autocatalytic cleavage%3B Belongs to the RecA family gene gene881 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00882 WSWS_00883 WSWS_00883 pncC pncC 925977 926450 - Nicotinamide-nucleotide amidase Belongs to the CinA family%3B KEGG: rch:RUM_23910 nicotinamide-nucleotide amidase gene gene882 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00883 WSWS_00884 WSWS_00884 WSWS_00884 926602 926674 - tRNA-Lys tRNA gene883 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00884 WSWS_00885 WSWS_00885 WSWS_00885 926753 927607 - hypothetical protein gene gene884 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00885 WSWS_00886 WSWS_00886 WSWS_00886 927609 928781 - Multidrug resistance protein MdtL Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2. A. 1. 2. 22) subfamily gene gene885 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00886 WSWS_00887 WSWS_00887 WSWS_00887 928936 929847 - 23S rRNA pseudouridine(1911/1915/1917) synthase Belongs to the pseudouridine synthase RluA family%3B KEGG: wko:WKK_01525 23S rRNA pseudouridine1911/1915/1917 synthase gene gene886 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00887 WSWS_00888 WSWS_00888 ppnK ppnK 929847 930656 - NAD(+) kinase Involved in the regulation of the intracellular balance of NAD and NADP%2C and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP%3B Belongs to the NAD kinase family%3B KEGG: thl:TEH_06820 NAD+ kinase gene gene887 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00888 WSWS_00889 WSWS_00889 WSWS_00889 930664 931263 - GTP diphosphokinase Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. YjbM has probably a minor role in stringent response%3B Belongs to the RelA/SpoT family%3B KEGG: lbh:Lbuc_0678 putative GTP pyrophosphokinase gene gene888 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00889 WSWS_00890 WSWS_00890 gntZ gntZ 931501 932934 - Phosphogluconate dehydrogenase (NADP(+)-dependent%2C decarboxylating) Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2)%2C with concomitant reduction of NADP to NADPH%3B Belongs to the 6-phosphogluconate dehydrogenase family%3B KEGG: dba:Dbac_0340 6-phosphogluconate dehydrogenase gene gene889 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00890 WSWS_00891 WSWS_00891 WSWS_00891 933115 934305 - UDP-galactopyranose mutase Involved in the conversion of UDP-GalP into UDP-GalF through a 2-keto intermediate%3B Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family%3B KEGG: lci:LCK_01139 UDP-galactopyranose mutase gene gene890 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00891 WSWS_00892 WSWS_00892 WSWS_00892 934309 935205 - Rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1%2C3/1%2C4-galactofuranosyltransferase Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex%2C an essential component the mycobacterial cell wall. It catalyzes the transfer of the first galactofuranosyl (Galf) unit from UDP- galactofuranosyl (UDP-Galf) onto the rhamnosyl-GlcNAc- pyrophosphoryl-undecaprenyl (Rha-GlcNAc-PP-C55) acceptor through a beta-D-(1->5) or a beta-D-(1->6) galactofuranosyltransferase activitie%2C yielding galactofuranosyl-rhamnosyl-GlcNAc- pyrophosphoryl-undecaprenyl (Galf-Rha-GlcNAc-PP-C55). GlfT1 is also able to catalyze the addition of the second Galf unit%3B Belongs to the glycosyltransferase 2 family%3B KEGG: tpr:Tpau_4102 rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1%2C3/1%2C4-galactofuranosyltransferase gene gene891 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00892 WSWS_00893 WSWS_00893 gatB gatB 935385 936824 - Asparaginyl-tRNA synthase (glutamine-hydrolyzing) Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)%3B Belongs to the GatB/GatE family. GatB subfamily%3B KEGG: ccx:COCOR_01364 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B%3B overlaps another CDS with the same product name gene gene892 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00893 WSWS_00894 WSWS_00894 gatA gatA 936824 938281 - Asparaginyl-tRNA synthase (glutamine-hydrolyzing) Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)%3B Belongs to the amidase family. GatA subfamily%3B KEGG: lsa:LSA1547 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A%3B overlaps another CDS with the same product name gene gene893 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00894 WSWS_00895 WSWS_00895 gatC gatC 938287 938589 - Asparaginyl-tRNA synthase (glutamine-hydrolyzing) Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)%3B Belongs to the GatC family%3B KEGG: sfu:Sfum_3504 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C gene gene894 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00895 WSWS_00896 WSWS_00896 rsmB rsmB 938693 940090 - 16S rRNA (cytosine(967)-C(5))-methyltransferase Specifically methylates the cytosines at positions 1400 (m5C1400)%2C 1404 (m5C1404) and 1407 (m5C1407) of 16S rRNA. C1400%2C C1404 and C1407 are methylated in a 30S subunit substrate%2C but only C1400 and C1404 are methylated when naked 16S rRNA is the substrate. Methylation by RsmF may facilitate growth at temperatures outside the optimal growth temperature%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family%3B KEGG: syn:slr0679 16S rRNA (cytosine967-C5)-methyltransferase gene gene895 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00896 WSWS_00897 WSWS_00897 WSWS_00897 940103 940942 - Putative phosphatase YcsE Belongs to the HAD-like hydrolase superfamily. Cof family gene gene896 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00897 WSWS_00898 WSWS_00898 WSWS_00898 940935 941084 - hypothetical protein gene gene897 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00898 WSWS_00899 WSWS_00899 WSWS_00899 941197 942186 - L-glyceraldehyde 3-phosphate reductase Catalyzes the stereospecific%2C NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). The physiological role of gpr is the detoxification of L-GAP%2C which may be formed by non- enzymatic racemization of GAP. Also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo (By similarity)%3B Belongs to the shaker potassium channel beta subunit family%3B KEGG: lme:LEUM_0699 L-glyceraldehyde 3-phosphate reductase%3B With NAD(+) or NADP(+) as acceptor gene gene898 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00899 WSWS_00900 WSWS_00900 WSWS_00900 942200 943171 - Ribose-phosphate diphosphokinase Involved in the biosynthesis of ribose 1%2C5-bisphosphate. Catalyzes the transfer of pyrophosphoryl group from ATP to ribose- 5-phosphate to yield phosphoribosyl diphosphate (PRPP) and AMP%3B Belongs to the ribose-phosphate pyrophosphokinase family%3B KEGG: mex:Mext_3875 ribose-phosphate pyrophosphokinase gene gene899 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00900 WSWS_00901 WSWS_00901 pyrD pyrD 943605 944537 + Dihydroorotate oxidase (fumarate) Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor%3B Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily%3B KEGG: wce:WS08_0824 dihydroorotate dehydrogenase (fumarate) gene gene900 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00901 WSWS_00902 WSWS_00902 WSWS_00902 944839 945402 + Putative HMP/thiamine permease protein YkoE Part of the ABC transporter complex YkoCDEF that could transport hydroxymethylpyrimidine (HMP) and/or thiamine. Could also transport other HMP-containing products. Probably responsible for the translocation of the substrate across the membrane (Probable) gene gene901 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00902 WSWS_00903 WSWS_00903 WSWS_00903 945413 946816 + Taurine import ATP-binding protein TauB Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Taurine importer (TC 3. A. 1. 17. 1) family%3B Contains 1 ABC transporter domain gene gene902 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00903 WSWS_00904 WSWS_00904 WSWS_00904 946809 947474 + hypothetical protein gene gene903 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00904 WSWS_00905 WSWS_00905 WSWS_00905 947880 949184 + hypothetical protein gene gene904 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00905 WSWS_00906 WSWS_00906 WSWS_00906 949709 951139 - putative dipeptidase Belongs to the peptidase C69 family%3B KEGG: lac:LBA1294 dipeptidase%3B Acting on peptide bonds (peptidases) gene gene905 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00906 WSWS_00907 WSWS_00907 WSWS_00907 951349 952347 - Membrane protein insertase MisCB Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex%2C as well as at least some lipoproteins (By similarity). Also involved in protein secretion processes. It has an overlapping%2C although partly distinct%2C function compared to SpoIIIJ(MisCB)%3B Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily gene gene906 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00907 WSWS_00908 WSWS_00908 WSWS_00908 952515 953015 - hypothetical protein gene gene907 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00908 WSWS_00909 WSWS_00909 WSWS_00909 953142 953687 + putative isochorismatase family protein PncA Belongs to the isochorismatase family gene gene908 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00909 WSWS_00910 WSWS_00910 WSWS_00910 953748 955412 - Adenine deaminase Belongs to the adenine deaminase family%3B KEGG: ooe:OEOE_0158 adenine deaminase gene gene909 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00910 WSWS_00911 WSWS_00911 guaB guaB 955488 956654 - IMP dehydrogenase Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP)%2C the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides%2C and therefore plays an important role in the regulation of cell growth%3B Belongs to the IMPDH/GMPR family%3B Contains 2 CBS domains%3B KEGG: mye:AB431_07015 IMP dehydrogenase gene gene910 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00911 WSWS_00912 WSWS_00912 WSWS_00912 956982 957647 - Putative hydrolase Putative hydrolase that may contribute to the degradation of aromatic compounds%3B Belongs to the AB hydrolase superfamily. AB hydrolase 2 family gene gene911 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00912 WSWS_00913 WSWS_00913 WSWS_00913 957804 958787 - Putative ring-cleaving dioxygenase MhqA Putative ring-cleavage dioxygenase that may contribute to the degradation of aromatic compounds%3B Belongs to the extradiol ring-cleavage dioxygenase family gene gene912 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00913 WSWS_00914 WSWS_00914 WSWS_00914 958862 959110 - hypothetical protein gene gene913 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00914 WSWS_00915 WSWS_00915 WSWS_00915 959259 959987 - putative transcriptional regulatory protein Belongs to the TACO1 family gene gene914 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00915 WSWS_00916 WSWS_00916 WSWS_00916 960159 960247 + tRNA-Ser tRNA gene915 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00916 WSWS_00917 WSWS_00917 WSWS_00917 961225 961470 - UPF0410 protein YdaS Belongs to the UPF0410 family gene gene916 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00917 WSWS_00918 WSWS_00918 WSWS_00918 961709 962443 - hypothetical protein gene gene917 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00918 WSWS_00919 WSWS_00919 dge1 dge1 962587 963672 - Diguanylate cyclase Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG%2C csgBAC/ymaD and adrA (yaic). Activity of this protein is antagonized by the diguanylate cyclase YdaM. In vitro has c-di-GMP phosphodiesterase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria%3B Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: vir:X953_01945 diguanylate cyclase gene gene918 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00919 WSWS_00920 WSWS_00920 WSWS_00920 963825 964358 - Isopentenyl-diphosphate Delta-isomerase Belongs to the Nudix hydrolase family%3B Contains 1 nudix hydrolase domain%3B KEGG: mau:Micau_0242 isopentenyl-diphosphate delta-isomerase gene gene919 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00920 WSWS_00921 WSWS_00921 WSWS_00921 964521 964967 - hypothetical protein gene gene920 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00921 WSWS_00922 WSWS_00922 WSWS_00922 964964 965899 - hypothetical protein gene gene921 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00922 WSWS_00923 WSWS_00923 WSWS_00923 965930 966739 - hypothetical protein gene gene922 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00923 WSWS_00924 WSWS_00924 WSWS_00924 966749 967840 - hypothetical protein gene gene923 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00924 WSWS_00925 WSWS_00925 WSWS_00925 967837 970920 - hypothetical protein gene gene924 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00925 WSWS_00926 WSWS_00926 WSWS_00926 970929 971447 - hypothetical protein gene gene925 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00926 WSWS_00927 WSWS_00927 WSWS_00927 971518 972594 - hypothetical protein gene gene926 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00927 WSWS_00928 WSWS_00928 WSWS_00928 972691 975492 - Tail tape measure protein gp18 This protein is located in the phage's tail tube. believed to function in the injection of lambda DNA into the host cell during early infection. Probably undergoes structural rearrangements leading to injection of the phage DNA into the host. Also functions in the assembly of the tail polymerization initiator complex and is postulated to act as a template to determine the tail length gene gene927 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00928 WSWS_00929 WSWS_00929 WSWS_00929 975732 976097 - hypothetical protein gene gene928 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00929 WSWS_00930 WSWS_00930 WSWS_00930 976178 976819 - hypothetical protein gene gene929 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00930 WSWS_00931 WSWS_00931 WSWS_00931 976824 977195 - hypothetical protein gene gene930 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00931 WSWS_00932 WSWS_00932 WSWS_00932 977204 977620 - hypothetical protein gene gene931 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00932 WSWS_00933 WSWS_00933 WSWS_00933 977613 977957 - hypothetical protein gene gene932 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00933 WSWS_00934 WSWS_00934 WSWS_00934 977938 978276 - hypothetical protein gene gene933 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00934 WSWS_00935 WSWS_00935 WSWS_00935 978341 979561 - hypothetical protein gene gene934 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00935 WSWS_00936 WSWS_00936 clpP clpP 979567 980292 - Endopeptidase Clp KEGG: spm:spyM18_0755 ATP-dependent Clp protease%2C protease subunit gene gene935 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00936 WSWS_00937 WSWS_00937 WSWS_00937 980308 981441 - hypothetical protein gene gene936 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00937 WSWS_00938 WSWS_00938 WSWS_00938 981444 981641 - hypothetical protein gene gene937 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00938 WSWS_00939 WSWS_00939 WSWS_00939 981638 983515 - hypothetical protein gene gene938 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00939 WSWS_00940 WSWS_00940 WSWS_00940 983502 983969 - hypothetical protein gene gene939 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00940 WSWS_00941 WSWS_00941 WSWS_00941 984181 984753 + uncharacterized protein gene gene940 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00941 WSWS_00942 WSWS_00942 WSWS_00942 984786 985280 - hypothetical protein gene gene941 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00942 WSWS_00943 WSWS_00943 WSWS_00943 985502 986965 - hypothetical protein gene gene942 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00943 WSWS_00944 WSWS_00944 WSWS_00944 987235 987822 - Maltose O-acetyltransferase May assist cellular detoxification by acetylating non- metabolizable pyranosides%2C thereby preventing their reentry into the cell. Belongs to the transferase hexapeptide repeat family%3B KEGG: cbk:CLL_A1995 maltose O-acetyltransferase gene gene943 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00944 WSWS_00945 WSWS_00945 WSWS_00945 987911 988321 - hypothetical protein gene gene944 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00945 WSWS_00946 WSWS_00946 WSWS_00946 988588 988749 - hypothetical protein gene gene945 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00946 WSWS_00947 WSWS_00947 WSWS_00947 988742 988930 - hypothetical protein gene gene946 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00947 WSWS_00948 WSWS_00948 WSWS_00948 988969 989370 - hypothetical protein gene gene947 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00948 WSWS_00949 WSWS_00949 WSWS_00949 989367 989564 - hypothetical protein gene gene948 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00949 WSWS_00950 WSWS_00950 WSWS_00950 989612 990310 - hypothetical protein gene gene949 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00950 WSWS_00951 WSWS_00951 WSWS_00951 990312 991136 - uncharacterized protein gene gene950 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00951 WSWS_00952 WSWS_00952 WSWS_00952 991339 991953 - hypothetical protein gene gene951 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00952 WSWS_00953 WSWS_00953 WSWS_00953 992048 992428 - hypothetical protein gene gene952 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00953 WSWS_00954 WSWS_00954 WSWS_00954 992428 992592 - hypothetical protein gene gene953 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00954 WSWS_00955 WSWS_00955 WSWS_00955 992601 992807 - hypothetical protein gene gene954 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00955 WSWS_00956 WSWS_00956 WSWS_00956 992939 993103 + hypothetical protein gene gene955 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00956 WSWS_00957 WSWS_00957 WSWS_00957 993121 993258 - hypothetical protein gene gene956 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00957 WSWS_00958 WSWS_00958 WSWS_00958 993255 993425 - hypothetical protein gene gene957 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00958 WSWS_00959 WSWS_00959 WSWS_00959 993460 993729 - hypothetical protein gene gene958 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00959 WSWS_00960 WSWS_00960 WSWS_00960 993747 994472 - hypothetical protein gene gene959 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00960 WSWS_00961 WSWS_00961 WSWS_00961 994498 994701 - hypothetical protein gene gene960 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00961 WSWS_00962 WSWS_00962 WSWS_00962 994959 995303 + hypothetical protein gene gene961 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00962 WSWS_00963 WSWS_00963 WSWS_00963 995304 995714 + hypothetical protein gene gene962 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00963 WSWS_00964 WSWS_00964 WSWS_00964 995804 996880 + hypothetical protein gene gene963 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00964 WSWS_00965 WSWS_00965 WSWS_00965 997005 997703 + hypothetical protein gene gene964 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00965 WSWS_00966 WSWS_00966 WSWS_00966 997700 998470 - hypothetical protein gene gene965 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00966 WSWS_00967 WSWS_00967 WSWS_00967 998839 999987 + hypothetical protein gene gene966 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00967 WSWS_00968 WSWS_00968 WSWS_00968 1000301 1000747 + hypothetical protein gene gene967 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00968 WSWS_00969 WSWS_00969 WSWS_00969 1000989 1001324 - hypothetical protein gene gene968 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00969 WSWS_00970 WSWS_00970 WSWS_00970 1001418 1001696 - hypothetical protein gene gene969 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00970 WSWS_00971 WSWS_00971 WSWS_00971 1001768 1002496 - hypothetical protein gene gene970 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00971 WSWS_00972 WSWS_00972 WSWS_00972 1002683 1003768 - Diguanylate cyclase Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus%2C catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface- associated traits in bacteria (By similarity)%3B Contains 1 GGDEF domain%3B KEGG: vir:X953_01945 diguanylate cyclase gene gene971 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00972 WSWS_00973 WSWS_00973 WSWS_00973 1004281 1004853 + hypothetical protein gene gene972 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00973 WSWS_00974 WSWS_00974 catE catE 1005117 1005932 - Catechol 2%2C3-dioxygenase Involved in the meta cleavage of catechol to 2- hydroxymuconic semialdehyde. Essential for growth and viability in the presence of catechol and probably involved in the detoxification of catechol%3B Belongs to the extradiol ring-cleavage dioxygenase family%3B KEGG: lki:LKI_04000 catechol 2%2C3-dioxygenase gene gene973 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00974 WSWS_00975 WSWS_00975 WSWS_00975 1006167 1006979 - hypothetical protein gene gene974 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00975 WSWS_00976 WSWS_00976 WSWS_00976 1006982 1008316 - Dolichyl-phosphate beta-D-mannosyltransferase Probable N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N- acetylglucosamine to produce the linear homopolymer poly-beta-1%2C6- N-acetyl-D-glucosamine (PGA)%2C a biofilm adhesin polysaccharide%3B Belongs to the glycosyltransferase 2 family%3B KEGG: pba:PSEBR_a2942 dolichol-phosphate mannosyltransferase gene gene975 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00976 WSWS_00977 WSWS_00977 WSWS_00977 1008309 1008830 - hypothetical protein gene gene976 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00977 WSWS_00978 WSWS_00978 WSWS_00978 1008898 1009644 - hypothetical protein gene gene977 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00978 WSWS_00979 WSWS_00979 WSWS_00979 1009881 1010951 - Protein AdrA Contains 1 GGDEF domain gene gene978 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00979 WSWS_00980 WSWS_00980 WSWS_00980 1011540 1012925 - Signal transduction histidine-protein kinase ArlS Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion%2C autolysis%2C multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: bha:BH0373 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene979 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00980 WSWS_00981 WSWS_00981 WSWS_00981 1012903 1013592 - Transcriptional regulatory protein AfsQ1 Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism. Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene980 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00981 WSWS_00982 WSWS_00982 WSWS_00982 1013644 1014930 - hypothetical protein gene gene981 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00982 WSWS_00983 WSWS_00983 WSWS_00983 1015162 1016766 - hypothetical protein gene gene982 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00983 WSWS_00984 WSWS_00984 gltL gltL 1016756 1017664 - Energy-dependent translational throttle protein EttA A translation factor that gates the progression of the 70S ribosomal inititation complex (IC%2C containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation (By similarity)%3B Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily%3B Contains 2 ABC transporter domains%3B KEGG: vap:Vapar_0831 glutamate/aspartate transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene983 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00984 WSWS_00985 WSWS_00985 WSWS_00985 1017974 1018195 - hypothetical protein gene gene984 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00985 WSWS_00986 WSWS_00986 WSWS_00986 1018299 1019453 - L-shaped tail fiber protein pb8 Assembles together with p132 to form the three L-shaped long tail fibers that recognize the host lipopolysaccharides that serve as adhesion receptor for virus entry. P132 makes the proximal part and pb8 the distal part that binds to the host cell surface. The L-shaped long tail fibers are attached to a collar structure at the junction between the tail tube and the conical tail tip. Each fiber consists of a thin proximal rod of about 30 nm connected by a hinge to a thicker distal part of about 47 nm%3B Contains 1 peptidase S74 domain gene gene985 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00986 WSWS_00987 WSWS_00987 WSWS_00987 1019714 1020319 - Putative hydrolase Contains 1 LysM repeat%3B Contains 1 peptidase C51 domain gene gene986 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00987 WSWS_00988 WSWS_00988 hisC hisC 1020873 1021868 - Histidinol-phosphate transaminase Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily%3B KEGG: cst:CLOST_0522 histidinol-phosphate aminotransferase gene gene987 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00988 WSWS_00989 WSWS_00989 WSWS_00989 1021980 1023704 - Phosphoglucomutase (alpha-D-glucose-1%2C6-bisphosphate-dependent) Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG)%2C i. e. the predominant glycolipid found in B. subtilis membrane%2C which is also used as a membrane anchor for lipoteichoic acid (LTA). Has a role in the biosynthesis of all phosphate-containing envelope polymers%2C since glucose-1-phosphate is the precursor of UDP-glucose%2C which serves as a glucosyl donor not only for the biosynthesis of LTA but also for wall teichoic acids (WTAs). Is required for biofilm formation. This is likely due to another role of UDP-glucose%2C which might also act as a metabolic signal regulating biofilm formation or may be involved in some unknown biosynthetic pathway essential for biofilm formation%2C e. g. the synthesis of an exopolysaccharide%3B Belongs to the phosphohexose mutase family%3B KEGG: dai:Desaci_2994 phosphoglucomutase gene gene988 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00989 WSWS_00990 WSWS_00990 WSWS_00990 1023933 1024436 + Phosphinothricin acetyltransferase Plays a role in the resistance against the toxic effects of L-methionine sulfoximine (MSX)%2C a rare amino acid which inhibits glutamine synthetase (GlnA). Catalyzes the acetylation of MSX. It can also use L-methionine sulfone (MSO)%3B Contains 1 N-acetyltransferase domain%3B KEGG: csc:Csac_2016 phosphinothricin acetyltransferase gene gene989 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00990 WSWS_00991 WSWS_00991 WSWS_00991 1024481 1025707 - uncharacterized protein To M. jannaschii MJ1024 gene gene990 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00991 WSWS_00992 WSWS_00992 cysA cysA 1025704 1026585 - Sulfate-transporting ATPase Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3. A. 1. 6) family%3B Contains 1 ABC transporter domain%3B KEGG: eco:b2422 sulfate transport system ATP-binding protein gene gene991 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00992 WSWS_00993 WSWS_00993 varS varS 1026719 1029382 - Valine--tRNA ligase Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine%2C to avoid such errors%2C it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner%3B Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily%3B KEGG: wko:WKK_01620 valyl-tRNA synthetase gene gene992 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00993 WSWS_00994 WSWS_00994 recD recD 1029701 1032229 - Exodeoxyribonuclease V DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs%2C requires at least 10 bases of 5'-ssDNA for helicase activity%3B Belongs to the RecD family. RecD-like subfamily%3B KEGG: pce:PECL_823 exodeoxyribonuclease V alpha subunit gene gene993 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00994 WSWS_00995 WSWS_00995 WSWS_00995 1032222 1032872 - hypothetical protein gene gene994 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00995 WSWS_00996 WSWS_00996 WSWS_00996 1032887 1033549 - Phosphoglycerate mutase (2%2C3-diphosphoglycerate-independent) Phosphoglycerate mutase-like protein lacking PGM activity%2C but having 2-carboxy-D-arabinitol 1-phosphate (CA1P) phosphatase activity. Prevents the accumulation of D-glycero-2%2C3- pentodiulose-1%2C5-bisphosphate (PDBP) a potent inhibitor of ribulose-1%2C5-bisphosphate carboxylase (RuBisCO). PDBP is produced during the oxidation of ribulose-1%2C5-bisphosphate%2C the substrate of RuBisCO%3B Belongs to the phosphoglycerate mutase family%3B KEGG: scp:HMPREF0833_10865 probable phosphoglycerate mutase gene gene995 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00996 WSWS_00997 WSWS_00997 WSWS_00997 1033645 1033989 - hypothetical protein gene gene996 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00997 WSWS_00998 WSWS_00998 WSWS_00998 1034096 1034635 + Acyl-CoA hydrolase Belongs to the acyl coenzyme A hydrolase family%3B Contains 1 HotDog ACOT-type domain%3B KEGG: ban:BA_2053 acyl-CoA hydrolase gene gene997 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00998 WSWS_00999 WSWS_00999 WSWS_00999 1034729 1035502 - Diacetyl reductase ((S)-acetoin forming) Catalyzes the reversible reduction of (S)-acetoin to 2%2C3-butanediol in the presence of NADH. Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: sty:STY2401 null%3B Oxidoreductases gene gene998 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_00999 WSWS_01000 WSWS_01000 WSWS_01000 1035682 1036503 - Stomatin like protein Belongs to the band 7/mec-2 family gene gene999 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01000 WSWS_01001 WSWS_01001 WSWS_01001 1036535 1036837 - hypothetical protein gene gene1000 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01001 WSWS_01002 WSWS_01002 WSWS_01002 1036856 1037212 - hypothetical protein gene gene1001 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01002 WSWS_01003 WSWS_01003 WSWS_01003 1037414 1039075 - hypothetical protein gene gene1002 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01003 WSWS_01004 WSWS_01004 WSWS_01004 1039089 1039847 - hypothetical protein gene gene1003 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01004 WSWS_01005 WSWS_01005 WSWS_01005 1040148 1040393 - UPF0410 protein YdaS Belongs to the UPF0410 family gene gene1004 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01005 WSWS_01006 WSWS_01006 WSWS_01006 1040747 1041019 - 30S ribosomal protein S16 Belongs to the ribosomal protein S16P family gene gene1005 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01006 WSWS_01007 WSWS_01007 glpQ glpQ 1041265 1042002 + Glycerophosphodiester phosphodiesterase Phosphatidylglycerol phospholipase required for the removal of excess phosphatidylglycerol (PG) via a phospholipase C- type degradation mechanism%3B Belongs to the glycerophosphoryl diester phosphodiesterase family%3B Contains 1 GP-PDE domain%3B KEGG: phl:KKY_337 glycerophosphoryl diester phosphodiesterase gene gene1006 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01007 WSWS_01008 WSWS_01008 WSWS_01008 1042143 1043384 - Pyrimidine nucleoside transport protein Belongs to the concentrative nucleoside transporter (CNT) (TC 2. A. 41) family gene gene1007 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01008 WSWS_01009 WSWS_01009 WSWS_01009 1043522 1044838 - Asc-type amino acid transporter Sodium-independent%2C high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse%3B Belongs to the amino acid-polyamine-organocation (APC) superfamily gene gene1008 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01009 WSWS_01010 WSWS_01010 WSWS_01010 1045015 1045863 - Cell shape-determining protein MreC Involved in formation and maintenance of cell shape%3B Belongs to the MreC family gene gene1009 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01010 WSWS_01011 WSWS_01011 WSWS_01011 1045936 1046940 - Rod shape-determining protein MreB Involved in formation of the rod shape of the cell%3B Belongs to the FtsA/MreB family gene gene1010 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01011 WSWS_01012 WSWS_01012 WSWS_01012 1047044 1047469 - UPF0758 protein Belongs to the UPF0758 family gene gene1011 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01012 WSWS_01013 WSWS_01013 WSWS_01013 1047564 1047893 + hypothetical protein gene gene1012 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01013 WSWS_01014 WSWS_01014 WSWS_01014 1047991 1048587 - hypothetical protein gene gene1013 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01014 WSWS_01015 WSWS_01015 mtnN mtnN 1048618 1049307 - Adenosylhomocysteine nucleosidase Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose%2C 5'-methylthioribose and S-ribosylhomocysteine%2C respectively%3B Belongs to the PNP/UDP phosphorylase family. MtnN subfamily%3B KEGG: wko:WKK_05605 adenosylhomocysteine nucleosidase gene gene1014 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01015 WSWS_01016 WSWS_01016 WSWS_01016 1049330 1049749 - hypothetical protein gene gene1015 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01016 WSWS_01017 WSWS_01017 nudF nudF 1049750 1050331 - ADP-ribose diphosphatase Involved in the activation of the NAD-dependent methanol dehydrogenase (MDH). MDH activation by Act involves hydrolytic removal of the nicotinamide mononucleotide (NMN) moiety of the NAD cofactor%2C changing its ping-pong type of reaction mechanism into a ternary complex reaction mechanism. It requires the presence of magnesium ions and is also able to use ADP-ribose%3B Belongs to the Nudix hydrolase family%3B KEGG: lsn:LSA_10020 ADP-ribose pyrophosphatase gene gene1016 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01017 WSWS_01018 WSWS_01018 WSWS_01018 1050334 1050543 - Major cold shock protein Can bind to ATTGG and CCAAT motifs (Y-box motifs) of single-stranded oligonucleotides%3B Contains 1 CSD (cold-shock) domain gene gene1017 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01018 WSWS_01019 WSWS_01019 WSWS_01019 1050560 1050928 - hypothetical protein gene gene1018 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01019 WSWS_01020 WSWS_01020 WSWS_01020 1051127 1051246 + hypothetical protein gene gene1019 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01020 WSWS_01021 WSWS_01021 WSWS_01021 1051516 1052601 + CD4+ T-cell-stimulating antigen Belongs to the BMP lipoprotein family gene gene1020 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01021 WSWS_01022 WSWS_01022 WSWS_01022 1052656 1054581 - Lipid A export ATP-binding/permease protein MsbA Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation%3B Belongs to the ABC transporter superfamily. Lipid exporter (TC 3. A. 1. 106) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene1021 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01022 WSWS_01023 WSWS_01023 WSWS_01023 1054584 1056293 - Putative ABC transporter ATP-binding protein Belongs to the ABC transporter superfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene1022 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01023 WSWS_01024 WSWS_01024 WSWS_01024 1056301 1056831 - hypothetical protein gene gene1023 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01024 WSWS_01025 WSWS_01025 WSWS_01025 1056945 1057511 - Folate transporter FolT Folate-binding protein that interacts with the energy- coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane%2C not extracytoplasmic soluble proteins (By similarity). Binds folic acid with a dissociation constant of 9 n%3B binds polyglutamyl folates less well. Upon coexpression with its energy-coupling factor (ECF) ABC- transporter complex EcfA1A2T in Lactococcus lactis subsp. cremoris (strain NZ9000) allows high level 5-formyltetrahydrofolate uptak%3B uptake requires both FolT and EcfA1A2T. Low levels of uptake occur in the presence of FolT alone%2C perhaps because it interacts with endogenous EcfA1A2T gene gene1024 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01025 WSWS_01026 WSWS_01026 WSWS_01026 1057738 1058622 - 23S rRNA pseudouridine(1911/1915/1917) synthase Responsible for synthesis of pseudouridine from uracil at positions 955%2C 2504 and 2580 in 23S ribosomal RNA%3B Belongs to the pseudouridine synthase RluA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: lca:LSEI_1726 23S rRNA pseudouridine1911/1915/1917 synthase gene gene1025 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01026 WSWS_01027 WSWS_01027 WSWS_01027 1058710 1059702 - Alcohol dehydrogenase Probably catalyzes the NADPH-dependent reduction of acrylyl-CoA to propanoyl-CoA%3B Belongs to the zinc-containing alcohol dehydrogenase family. Acrylyl-CoA reductase subfamily%3B KEGG: rle:pRL120182 alcohol dehydrogenase gene gene1026 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01027 WSWS_01028 WSWS_01028 WSWS_01028 1059714 1060889 - Putative aminotransferase YugH Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: lgs:LEGAS_0801 aminotransferase%3B Transaminases gene gene1027 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01028 WSWS_01029 WSWS_01029 vanX vanX 1061059 1061799 + D-Ala-D-Ala dipeptidase KEGG: ooe:OEOE_0214 D-alanyl-D-alanine dipeptidase gene gene1028 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01029 WSWS_01030 WSWS_01030 rimJ rimJ 1061891 1062442 - Ribosomal-protein-alanine N-acetyltransferase This enzyme acetylates the N-terminal alanine of ribosomal protein S5%3B Belongs to the acetyltransferase family. RimJ subfamily%3B Contains 1 N-acetyltransferase domain%3B KEGG: siv:SSIL_3756 ribosomal-protein-alanine N-acetyltransferase gene gene1029 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01030 WSWS_01031 WSWS_01031 WSWS_01031 1062543 1062656 - hypothetical protein gene gene1030 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01031 WSWS_01032 WSWS_01032 WSWS_01032 1062718 1064076 - Na(+)/H(+) antiporter NhaC Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion%3B Belongs to the NhaC Na(+)/H(+) (TC 2. A. 35) antiporter family gene gene1031 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01032 WSWS_01033 WSWS_01033 WSWS_01033 1064449 1065231 - putative metal transport system membrane protein Part of an ATP-driven transport system TM_0123/TM_0124/TM_0125 for a metal. Belongs to the ABC-3 integral membrane protein family gene gene1032 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01033 WSWS_01034 WSWS_01034 afuC afuC 1065224 1065913 - Fe(3+)-transporting ATPase Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Zinc importer (TC 3. A. 1. 15. 5) family%3B Contains 1 ABC transporter domain%3B KEGG: mvr:X781_10300 iron(III) transport system ATP-binding protein gene gene1033 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01034 WSWS_01035 WSWS_01035 WSWS_01035 1065913 1066821 - hypothetical protein gene gene1034 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01035 WSWS_01036 WSWS_01036 WSWS_01036 1066831 1067295 - hypothetical protein gene gene1035 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01036 WSWS_01037 WSWS_01037 xylB xylB 1067510 1069036 - Xylulokinase Belongs to the FGGY kinase family%3B KEGG: bck:BCO26_0367 xylulokinase gene gene1036 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01037 WSWS_01038 WSWS_01038 hdhA hdhA 1069129 1069908 - 7-alpha-hydroxysteroid dehydrogenase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: pha:PSHAa2129 7-alpha-hydroxysteroid dehydrogenase gene gene1037 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01038 WSWS_01039 WSWS_01039 WSWS_01039 1070125 1071255 + Glucokinase Belongs to the ROK (NagC/XylR) family%3B KEGG: bcl:ABC1731 glucokinase gene gene1038 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01039 WSWS_01040 WSWS_01040 WSWS_01040 1071487 1072911 + Lactose permease In the N-terminal sectio%3B belongs to the sodium:galactoside symporter (TC 2. A. 2) family%3B Contains 1 PTS EIIA type-1 domain gene gene1039 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01040 WSWS_01041 WSWS_01041 WSWS_01041 1072922 1073167 + hypothetical protein gene gene1040 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01041 WSWS_01042 WSWS_01042 WSWS_01042 1073245 1074090 - D-methionine-binding lipoprotein MetQ This protein is a component of a D-methionine permease%2C a binding protein-dependent%2C ATP-driven transport system%3B Belongs to the NlpA lipoprotein family gene gene1041 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01042 WSWS_01043 WSWS_01043 WSWS_01043 1074117 1075451 - Succinyl-diaminopimelate desuccinylase Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly%3B Belongs to the peptidase M20A family%3B KEGG: lme:LEUM_0429 succinyl-diaminopimelate desuccinylase gene gene1042 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01043 WSWS_01044 WSWS_01044 WSWS_01044 1075837 1076694 - hypothetical protein gene gene1043 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01044 WSWS_01045 WSWS_01045 yicI yicI 1076814 1078949 - Alpha-D-xyloside xylohydrolase Catalyzes the liberation of alpha-xylose from the non- reducing terminal glucose of xyloglucan oligosaccharides%3B Belongs to the glycosyl hydrolase 31 family%3B KEGG: lme:LEUM_1244 alpha-D-xyloside xylohydrolase gene gene1044 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01045 WSWS_01046 WSWS_01046 WSWS_01046 1078965 1080431 - putative symporter YnaJ Belongs to the sodium:galactoside symporter (TC 2. A. 2) family gene gene1045 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01046 WSWS_01047 WSWS_01047 WSWS_01047 1080686 1081126 - hypothetical protein gene gene1046 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01047 WSWS_01048 WSWS_01048 WSWS_01048 1081192 1082040 - Aldose reductase Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies%3B Belongs to the aldo/keto reductase family%3B KEGG: llm:llmg_2065 null%3B With NAD(+) or NADP(+) as acceptor gene gene1047 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01048 WSWS_01049 WSWS_01049 codA codA 1082260 1082913 + Cytosine deaminase Belongs to the UPF0659 family%3B KEGG: sfa:Sfla_2548 cytosine deaminase gene gene1048 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01049 WSWS_01050 WSWS_01050 WSWS_01050 1083077 1084453 - D-xylose-proton symporter Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system)%3B Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family gene gene1049 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01050 WSWS_01051 WSWS_01051 araA araA 1084481 1085905 - L-arabinose isomerase Catalyzes the conversion of L-arabinose to L-ribulose%3B Belongs to the arabinose isomerase family%3B KEGG: wko:WKK_01700 L-arabinose isomerase gene gene1050 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01051 WSWS_01052 WSWS_01052 araD araD 1085934 1086665 - L-ribulose-5-phosphate 4-epimerase Belongs to the aldolase class II family. AraD/FucA subfamily%3B KEGG: hso:HS_0773 L-ribulose-5-phosphate 4-epimerase gene gene1051 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01052 WSWS_01053 WSWS_01053 araB araB 1086674 1088269 - Ribulokinase KEGG: lsa:LSA1859 L-ribulokinase gene gene1052 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01053 WSWS_01054 WSWS_01054 WSWS_01054 1088472 1089554 - Arabinose metabolism transcriptional repressor Transcriptional repressor of the arabinose utilization genes%3B Contains 1 HTH gntR-type DNA-binding domain gene gene1053 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01054 WSWS_01055 WSWS_01055 scrK scrK 1089746 1090618 - Fructokinase Belongs to the ROK (NagC/XylR) family%3B KEGG: lmu:LBLM1_04300 fructokinase gene gene1054 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01055 WSWS_01056 WSWS_01056 sacA sacA 1090630 1091868 - Beta-fructofuranosidase Belongs to the glycosyl hydrolase 32 family%3B KEGG: lcn:C270_03080 beta-fructofuranosidase gene gene1055 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01056 WSWS_01057 WSWS_01057 WSWS_01057 1091868 1093790 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in sucrose transport. Contains 1 PTS EIIA type-1 domain%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: llt:CVCAS_0602 PTS system%2C sucrose-specific IIA component gene gene1056 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01057 WSWS_01058 WSWS_01058 WSWS_01058 1093919 1094872 - Sucrose operon repressor Negative regulator of scrB expression. Contains 1 HTH lacI-type DNA-binding domain gene gene1057 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01058 WSWS_01059 WSWS_01059 WSWS_01059 1094982 1096106 - hypothetical protein gene gene1058 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01059 WSWS_01060 WSWS_01060 WSWS_01060 1096492 1097439 + putative 42.1 kDa protein in intracellular alkaline protease 3'region gene gene1059 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01060 WSWS_01061 WSWS_01061 WSWS_01061 1097559 1098548 - D-lactate dehydrogenase Has both D-lactate and D-glycerate dehydrogenase activities. Equally active on pyruvate and hydroxypyruvate. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B KEGG: brm:Bmur_2742 D-lactate dehydrogenase gene gene1060 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01061 WSWS_01062 WSWS_01062 glmS glmS 1098804 1100618 - Glutamine--fructose-6-phosphate transaminase (isomerizing) Catalyzes the first step in hexosamine metabolism%2C converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source%3B Contains 1 glutamine amidotransferase type-2 domain%3B Contains 2 SIS domains%3B KEGG: dps:DP2915 glucosamine--fructose-6-phosphate aminotransferase (isomerizing) gene gene1061 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01062 WSWS_01063 WSWS_01063 WSWS_01063 1100767 1102023 - putative ammonia channel Involved in the uptake of ammonia%3B Belongs to the ammonia transporter channel (TC 1. A. 11. 2) family gene gene1062 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01063 WSWS_01064 WSWS_01064 amiA amiA 1102238 1103134 - N-acetylmuramoyl-L-alanine amidase Cell-wall hydrolase involved in septum cleavage during cell division%3B Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family%3B Contains 2 LysM repeats%3B KEGG: wko:WKK_05725 N-acetylmuramoyl-L-alanine amidase gene gene1063 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01064 WSWS_01065 WSWS_01065 WSWS_01065 1103199 1103642 - Nucleoside deoxyribosyltransferase KEGG: lme:LEUM_0444 nucleoside deoxyribosyltransferase gene gene1064 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01065 WSWS_01066 WSWS_01066 WSWS_01066 1103752 1104786 - putative low-affinity inorganic phosphate transporter Low-affinity inorganic phosphate transport%3B Belongs to the inorganic phosphate transporter (PiT) (TC 2. A. 20) family. Pit subfamily gene gene1065 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01066 WSWS_01067 WSWS_01067 poxL poxL 1105044 1106843 - Pyruvate oxidase Important for the aerobic growth. Decarboxylates pyruvate in four steps. The energy released is partially stored in acetyl phosphate. Belongs to the TPP enzyme family%3B KEGG: ppe:PEPE_1252 pyruvate oxidase gene gene1066 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01067 WSWS_01068 WSWS_01068 WSWS_01068 1107043 1107504 - hypothetical protein gene gene1067 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01068 WSWS_01069 WSWS_01069 WSWS_01069 1107519 1108892 - Divalent metal cation transporter MntH H(+)-stimulated%2C divalent metal cation uptake system%3B Belongs to the NRAMP family gene gene1068 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01069 WSWS_01070 WSWS_01070 WSWS_01070 1109522 1109995 - hypothetical protein gene gene1069 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01070 WSWS_01071 WSWS_01071 WSWS_01071 1110055 1110354 - hypothetical protein gene gene1070 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01071 WSWS_01072 WSWS_01072 WSWS_01072 1110359 1111795 - UPF0051 protein Belongs to the UPF0051 (ycf24) family%3B Contains 1 DOD-type homing endonuclease domain gene gene1071 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01072 WSWS_01073 WSWS_01073 WSWS_01073 1111782 1112237 - Iron-sulfur cluster assembly scaffold protein IscU A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity)%3B Belongs to the NifU family gene gene1072 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01073 WSWS_01074 WSWS_01074 sufS sufS 1112241 1113473 - Cysteine desulfurase Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine%2C L-cystine%2C L-selenocysteine%2C and L- selenocystine to produce L-alanine%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily%3B KEGG: pbr:PB2503_09924 cysteine desulfurase / selenocysteine lyase gene gene1073 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01074 WSWS_01075 WSWS_01075 WSWS_01075 1113451 1114164 - FeS cluster assembly protein SufD The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation (By similarity)%3B Belongs to the UPF0051 (ycf24) family gene gene1074 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01075 WSWS_01076 WSWS_01076 WSWS_01076 1114161 1114943 - putative ATP-dependent transporter ycf16 Belongs to the ABC transporter superfamily. Ycf16 family%3B Contains 1 ABC transporter domain gene gene1075 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01076 WSWS_01077 WSWS_01077 nrdG nrdG 1114962 1115624 - [Formate-C-acetyltransferase]-activating enzyme Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical%2C using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine%3B Belongs to the organic radical-activating enzymes family%3B KEGG: lia:JL58_01545 anaerobic ribonucleoside-triphosphate reductase activating protein gene gene1076 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01077 WSWS_01078 WSWS_01078 nrdD nrdD 1115587 1117731 - Ribonucleoside-triphosphate reductase Belongs to the anaerobic ribonucleoside-triphosphate reductase family%3B Contains 1 glycine radical domain%3B KEGG: lki:LKI_07845 ribonucleoside-triphosphate reductase gene gene1077 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01078 WSWS_01079 WSWS_01079 WSWS_01079 1117926 1118186 - Glutaredoxin-like protein NrdH Electron transport system for the ribonucleotide reductase system NrdEF. Belongs to the glutaredoxin family%3B Contains 1 glutaredoxin domain gene gene1078 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01079 WSWS_01080 WSWS_01080 WSWS_01080 1118359 1118577 - hypothetical protein gene gene1079 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01080 WSWS_01081 WSWS_01081 WSWS_01081 1118574 1120142 - Peptide chain release factor Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP%2C but not by GMP%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene1080 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01081 WSWS_01082 WSWS_01082 WSWS_01082 1120345 1121511 - Hydroxymethylglutaryl-CoA synthase Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP)%2C a key precursor for the biosynthesis of isoprenoid compounds%3B Belongs to the HMG-CoA synthase family%3B KEGG: dno:DNO_0799 hydroxymethylglutaryl-CoA synthase gene gene1081 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01082 WSWS_01083 WSWS_01083 WSWS_01083 1121513 1122718 - Phosphopantothenoylcysteine decarboxylase Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine%2C in the latter compound is decarboxylated to form 4'-phosphopantotheine (By similarity)%3B In the N-terminal sectio%3B belongs to the HFCD (homo- oligomeric flavin containing Cys decarboxylase) superfamily%3B In the C-terminal sectio%3B belongs to the PPC synthetase family%3B KEGG: lbh:Lbuc_1138 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase gene gene1082 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01083 WSWS_01084 WSWS_01084 WSWS_01084 1122827 1122898 + tRNA-Glu tRNA gene1083 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01084 WSWS_01085 WSWS_01085 WSWS_01085 1122937 1123008 + tRNA-Glu tRNA gene1084 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01085 WSWS_01086 WSWS_01086 metB metB 1123067 1124182 - Cystathionine gamma-synthase Catalyzes the conversion of cystathionine to cysteine%2C and homocysteine to sulfide%3B Belongs to the trans-sulfuration enzymes family%3B KEGG: lpl:lp_2634 cystathionine gamma-synthase gene gene1085 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01086 WSWS_01087 WSWS_01087 WSWS_01087 1124761 1125459 - hypothetical protein gene gene1086 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01087 WSWS_01088 WSWS_01088 WSWS_01088 1125542 1126453 - Chaperone protein DnaJ Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins%2C also in an autonomous%2C DnaK-independent fashion. Unfolded proteins bind initially to Dna%3B upon interaction with the DnaJ-bound protein%2C DnaK hydrolyzes its bound ATP%2C resulting in the formation of a stable complex. GrpE releases ADP from Dna%3B ATP binding to DnaK triggers the release of the substrate protein%2C thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ%2C DnaK and GrpE are required for fully efficient folding. Also involved%2C together with DnaK and GrpE%2C in the DNA replication of plasmids through activation of initiation proteins%3B Belongs to the DnaJ family%3B Contains 1 CR-type zinc finger%3B Contains 1 J domain gene gene1087 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01088 WSWS_01089 WSWS_01089 WSWS_01089 1126614 1128440 - Chaperone protein DnaK Acts as a chaperone%3B Belongs to the heat shock protein 70 family gene gene1088 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01089 WSWS_01090 WSWS_01090 WSWS_01090 1128568 1129125 - Protein GrpE Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins%2C in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to Dna%3B upon interaction with the DnaJ-bound protein%2C DnaK hydrolyzes its bound ATP%2C resulting in the formation of a stable complex. GrpE releases ADP from Dna%3B ATP binding to DnaK triggers the release of the substrate protein%2C thus completing the reaction cycle. Several rounds of ATP- dependent interactions between DnaJ%2C DnaK and GrpE are required for fully efficient folding%3B Belongs to the GrpE family gene gene1089 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01090 WSWS_01091 WSWS_01091 WSWS_01091 1129141 1130163 - Heat-inducible transcription repressor HrcA Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons%3B Belongs to the HrcA family gene gene1090 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01091 WSWS_01092 WSWS_01092 WSWS_01092 1130325 1130624 - UPF0045 protein Belongs to the UPF0045 family gene gene1091 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01092 WSWS_01093 WSWS_01093 WSWS_01093 1130805 1130933 - hypothetical protein gene gene1092 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01093 WSWS_01094 WSWS_01094 WSWS_01094 1131016 1132185 - uncharacterized protein gene gene1093 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01094 WSWS_01095 WSWS_01095 WSWS_01095 1132357 1132968 + hypothetical protein gene gene1094 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01095 WSWS_01096 WSWS_01096 WSWS_01096 1133015 1133155 - hypothetical protein gene gene1095 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01096 WSWS_01097 WSWS_01097 WSWS_01097 1133197 1136376 - Nuclease SbcCD subunit C SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity)%3B Belongs to the SMC family. SbcC subfamily gene gene1096 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01097 WSWS_01098 WSWS_01098 WSWS_01098 1136378 1137538 - Nuclease SbcCD subunit SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity)%3B Belongs to the SbcD family gene gene1097 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01098 WSWS_01099 WSWS_01099 WSWS_01099 1137681 1138187 + hypothetical protein gene gene1098 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01099 WSWS_01100 WSWS_01100 WSWS_01100 1138309 1138818 - hypothetical protein gene gene1099 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01100 WSWS_01101 WSWS_01101 pgsA pgsA 1139023 1139607 - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase This protein catalyzes the committed step to the synthesis of the acidic phospholipids%3B Belongs to the CDP-alcohol phosphatidyltransferase class-I family%3B KEGG: bha:BH2386 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase gene gene1100 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01101 WSWS_01102 WSWS_01102 WSWS_01102 1139628 1140551 - putative membrane protein YmfM gene gene1101 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01102 WSWS_01103 WSWS_01103 WSWS_01103 1140670 1141944 - Insulysin Belongs to the peptidase M16 family%3B KEGG: bcz:BCZK3546 insulysin gene gene1102 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01103 WSWS_01104 WSWS_01104 WSWS_01104 1141941 1143227 - putative inactive metalloprotease YmfF Belongs to the peptidase M16 family gene gene1103 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01104 WSWS_01105 WSWS_01105 WSWS_01105 1143255 1144715 - Cardiolipin synthase Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol%3B Belongs to the phospholipase D family. Cardiolipin synthase subfamily%3B Contains 2 PLD phosphodiesterase domains%3B KEGG: bco:Bcell_1985 cardiolipin synthase%3B Transferases for other substituted phosphate groups gene gene1104 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01105 WSWS_01106 WSWS_01106 ltaS ltaS 1144977 1147247 - Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate%2C a reaction that presumably uses phosphatidylglycerol (PG) as substrate. Is required for staphylococcal growth and cell division process (By similarity)%3B Belongs to the LTA synthase family%3B KEGG: wko:WKK_01915 lipoteichoic acid synthase gene gene1105 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01106 WSWS_01107 WSWS_01107 WSWS_01107 1147344 1147595 - hypothetical protein gene gene1106 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01107 WSWS_01108 WSWS_01108 WSWS_01108 1147592 1148614 - hypothetical protein gene gene1107 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01108 WSWS_01109 WSWS_01109 cpoA cpoA 1148627 1149658 - Alpha-galactosylglucosyldiacylglycerol synthase Galactosyltransferase involved in the biosynthesis of the bilayer-forming membrane lipid alpha-galactosyl- glucosyldiacylglycerol which is involved in maintaining constant nonbilayer/bilayer conditions (curvature packing stress). Also involved in the beta-lactam resistance. Catalyzes the transfer of a galactosyl residue from UDP-Gal to alpha-glucosyl-DAG (1%2C2- diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol) acceptor to form the corresponding galactosyl-glycosyl-DAG product (3-O-alpha-(D- galactopyranosyl-alpha-(1->2)-D-glucopyranosyl)-1%2C2-diacyl-sn- glycerol). It can only use UDP-Gal as sugar donor and alpha- glucosyl-DAG is the preferred sugar acceptor%3B Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: lrf:LAR_1253 1%2C2-diacylglycerol-3-alpha-glucose alpha-1%2C2-galactosyltransferase%3B Hexosyltransferases gene gene1108 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01109 WSWS_01110 WSWS_01110 bgsB bgsB 1149655 1150899 - Alpha-monoglucosyldiacylglycerol synthase Glucosyltransferase involved in the biosynthesis of the non-bilayer-prone membrane lipid alpha-monoglucosyldiacylglycerol. This is a major component for maintaining a certain anionic lipid surface charge density%2C for balancing the bilayer to non-bilayer phase equilibria and for keeping a constant lipid bilayer spontaneous curvature (curvature packing stress). Catalyzes the transfer of a glucosyl residue from UDP-Glc to diacylglycerol (DAG) acceptor to form the corresponding alpha-glucosyl-DAG (1%2C2- diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol). It can only use UDP-Glc as sugar donor%3B Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: bcl:ABC1852 1%2C2-diacylglycerol 3-alpha-glucosyltransferase%3B Hexosyltransferases gene gene1109 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01110 WSWS_01111 WSWS_01111 nagB nagB 1151209 1151919 - Glucosamine-6-phosphate deaminase Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion%3B Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily%3B KEGG: wce:WS08_0910 glucosamine-6-phosphate deaminase gene gene1110 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01111 WSWS_01112 WSWS_01112 WSWS_01112 1152046 1153578 - Glycerol kinase Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate%3B Belongs to the FGGY kinase family%3B KEGG: aci:ACIAD0930 glycerol kinase gene gene1111 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01112 WSWS_01113 WSWS_01113 cbf1 cbf1 1153715 1154671 - 3'-5' exoribonuclease YhaM Shows a 3'-5' exoribonuclease activity%3B Belongs to the YhaM family%3B Contains 1 HD domain%3B Contains 1 OB DNA-binding domain%3B KEGG: wko:WKK_01410 3'-5' exoribonuclease%3B Acting on ester bonds gene gene1112 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01113 WSWS_01114 WSWS_01114 WSWS_01114 1154730 1156163 - DNA recombination protein RmuC like protein Involved in DNA recombination%3B Belongs to the RmuC family gene gene1113 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01114 WSWS_01115 WSWS_01115 WSWS_01115 1156685 1157026 - UPF0342 protein Belongs to the UPF0342 family gene gene1114 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01115 WSWS_01116 WSWS_01116 WSWS_01116 1157041 1159134 - Penicillin-binding protein 1A In the N-terminal sectio%3B belongs to the glycosyltransferase 51 family%3B In the C-terminal sectio%3B belongs to the transpeptidase family%3B KEGG: ljo:LJ1678 penicillin-binding protein 2A%3B Peptidoglycan glycosyltransferase gene gene1115 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01116 WSWS_01117 WSWS_01117 WSWS_01117 1159151 1159609 - Arginine repressor Regulates arginine biosynthesis genes%3B Belongs to the ArgR family gene gene1116 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01117 WSWS_01118 WSWS_01118 WSWS_01118 1159755 1161593 - Elongation factor Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction%2C by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex%2C thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene1117 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01118 WSWS_01119 WSWS_01119 WSWS_01119 1161709 1163076 - 23S rRNA (uracil(1939)-C(5))-methyltransferase Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family%3B Contains 1 TRAM domain%3B KEGG: bli:BL02629 23S rRNA (uracil1939-C5)-methyltransferase gene gene1118 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01119 WSWS_01120 WSWS_01120 WSWS_01120 1163258 1164373 - uncharacterized protein Belongs to the TelA family gene gene1119 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01120 WSWS_01121 WSWS_01121 WSWS_01121 1164370 1165146 - hypothetical protein gene gene1120 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01121 WSWS_01122 WSWS_01122 WSWS_01122 1165164 1165676 - Phosphinothricin acetyltransferase Plays a role in the resistance against the toxic effects of L-methionine sulfoximine (MSX)%2C a rare amino acid which inhibits glutamine synthetase (GlnA). Catalyzes the acetylation of MSX. It can also use L-methionine sulfone (MSO)%3B Contains 1 N-acetyltransferase domain%3B KEGG: prw:PsycPRwf_0628 phosphinothricin acetyltransferase gene gene1121 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01122 WSWS_01123 WSWS_01123 WSWS_01123 1165787 1166395 - Putative nitroreductase HBN1 Belongs to the nitroreductase family gene gene1122 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01123 WSWS_01124 WSWS_01124 WSWS_01124 1166629 1167993 - D-serine/D-alanine/glycine transporter Permease that is involved in the transport across the cytoplasmic membrane of D-alanine%2C D-serine and glycine%3B Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2. A. 3. 1) family gene gene1123 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01124 WSWS_01125 WSWS_01125 WSWS_01125 1168172 1168378 - UPF0337 protein YhjA Belongs to the UPF0337 (CsbD) family gene gene1124 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01125 WSWS_01126 WSWS_01126 WSWS_01126 1168611 1168853 - 50S ribosomal protein L31 type Belongs to the ribosomal protein L31P family. Type B subfamily gene gene1125 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01126 WSWS_01127 WSWS_01127 WSWS_01127 1169045 1169119 - tRNA-Gly tRNA gene1126 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01127 WSWS_01128 WSWS_01128 pyrE pyrE 1169188 1169823 - Orotate phosphoribosyltransferase Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate%2C leading to the formation of orotidine monophosphate (OMP)%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily%3B KEGG: bcl:ABC2329 orotate phosphoribosyltransferase gene gene1127 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01128 WSWS_01129 WSWS_01129 pyrF pyrF 1169820 1170548 - Orotidine-5'-phosphate decarboxylase Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)%3B Belongs to the OMP decarboxylase family. Type 1 subfamily%3B KEGG: ooe:OEOE_0262 orotidine-5'-phosphate decarboxylase gene gene1128 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01129 WSWS_01130 WSWS_01130 WSWS_01130 1170541 1171506 - Dihydroorotate dehydrogenase (NAD(+)) Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor. Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily%3B KEGG: sif:Sinf_0734 dihydroorotate dehydrogenase (NAD+) catalytic subunit gene gene1129 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01130 WSWS_01131 WSWS_01131 WSWS_01131 1171617 1174796 - Carbamoyl-phosphate synthase (glutamine-hydrolyzing) Belongs to the CarB family%3B Contains 2 ATP-grasp domains%3B KEGG: hde:HDEF_0108 carbamoyl-phosphate synthase large subunit%3B overlaps another CDS with the same product name gene gene1130 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01131 WSWS_01132 WSWS_01132 WSWS_01132 1174789 1175871 - Carbamoyl-phosphate synthase (glutamine-hydrolyzing) Belongs to the CarA family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: pln:Plano_1953 carbamoyl-phosphate synthase small subunit%3B overlaps another CDS with the same product name gene gene1131 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01132 WSWS_01133 WSWS_01133 ura4 ura4 1175899 1177176 - Dihydroorotase Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring%3B Belongs to the DHOase family. Allantoinase subfamily%3B KEGG: wce:WS08_0214 dihydroorotase gene gene1132 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01133 WSWS_01134 WSWS_01134 pyrB pyrB 1177178 1178074 - Aspartate carbamoyltransferase Belongs to the ATCase/OTCase family%3B KEGG: exm:U719_10965 aspartate carbamoyltransferase catalytic subunit gene gene1133 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01134 WSWS_01135 WSWS_01135 WSWS_01135 1178310 1178621 - hypothetical protein gene gene1134 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01135 WSWS_01136 WSWS_01136 glmM glmM 1178643 1180007 - Phosphoglucosamine mutase Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate%3B Belongs to the phosphohexose mutase family%3B KEGG: wko:WKK_01945 phosphoglucosamine mutase gene gene1135 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01136 WSWS_01137 WSWS_01137 WSWS_01137 1180009 1180986 - YbbR-like domain-containing protein YbbR Contains 4 YbbR-like domains gene gene1136 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01137 WSWS_01138 WSWS_01138 dacA dacA 1180988 1181830 - Diadenylate cyclase Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP)%2C a signaling compound secreted into the host's cytosol where it triggers the cytosolic surveillance pathway (CSP)%2C a host pathway of innate immunity characterized by expression of beta interferon (IFN-beta) and coregulated genes%3B KEGG: wce:WS08_0209 diadenylate cyclase gene gene1137 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01138 WSWS_01139 WSWS_01139 WSWS_01139 1181831 1183891 - putative Na(+)/H(+) exchanger Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2. A. 36) family gene gene1138 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01139 WSWS_01140 WSWS_01140 murB murB 1183913 1184812 - UDP-N-acetylmuramate dehydrogenase Cell wall formation%3B Belongs to the MurB family%3B Contains 1 FAD-binding PCMH-type domain%3B KEGG: lmu:LBLM1_09030 UDP-N-acetylmuramate dehydrogenase gene gene1139 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01140 WSWS_01141 WSWS_01141 dnaQ dnaQ 1184822 1185361 - DNA-directed DNA polymerase Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity%3B Belongs to the DNA polymerase type-C family. PolC subfamily%3B Contains 1 exonuclease domain%3B KEGG: lpl:lp_0811 DNA polymerase III subunit epsilon gene gene1140 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01141 WSWS_01142 WSWS_01142 speG speG 1185364 1185876 - Diamine N-acetyltransferase Belongs to the acetyltransferase family%3B Contains 1 N-acetyltransferase domain%3B KEGG: lsn:LSA_02370 diamine N-acetyltransferase gene gene1141 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01142 WSWS_01143 WSWS_01143 WSWS_01143 1185867 1186340 - tRNA threonylcarbamoyladenosine biosynthesis protein TsaE Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37%2C together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway%2C possibly in regulating the core enzymatic function of TsaD (By similarity)%3B Belongs to the TsaE family gene gene1142 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01143 WSWS_01144 WSWS_01144 WSWS_01144 1186527 1186769 - Acyl carrier protein Carrier of the growing fatty acid chain in fatty acid biosynthesis%3B Contains 1 acyl carrier domain gene gene1143 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01144 WSWS_01145 WSWS_01145 plsX plsX 1186869 1187915 - Glycerol-3-phosphate 1-O-acyltransferase Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor%2C but not acyl-CoA%3B Belongs to the PlsX family%3B KEGG: mmw:Mmwyl1_2130 glycerol-3-phosphate acyltransferase PlsX gene gene1144 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01145 WSWS_01146 WSWS_01146 recG recG 1188004 1190037 - DNA helicase Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) (By similarity)%3B Belongs to the helicase family. RecG subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: lsa:LSA0699 ATP-dependent DNA helicase RecG gene gene1145 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01146 WSWS_01147 WSWS_01147 WSWS_01147 1190121 1191809 - uncharacterized protein Contains 1 DhaL domain gene gene1146 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01147 WSWS_01148 WSWS_01148 WSWS_01148 1191845 1192204 - uncharacterized protein Belongs to the asp23 family gene gene1147 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01148 WSWS_01149 WSWS_01149 WSWS_01149 1192407 1192607 - 50S ribosomal protein L28 Belongs to the ribosomal protein L28P family gene gene1148 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01149 WSWS_01150 WSWS_01150 thiN thiN 1192715 1193368 - Thiamine diphosphokinase KEGG: lmo:lmo1817 thiamine pyrophosphokinase gene gene1149 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01150 WSWS_01151 WSWS_01151 WSWS_01151 1193368 1194027 - Ribulose-phosphate 3-epimerase Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate%3B Belongs to the ribulose-phosphate 3-epimerase family%3B KEGG: ade:Adeh_3971 ribulose-phosphate 3-epimerase gene gene1150 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01151 WSWS_01152 WSWS_01152 rsgA rsgA 1194117 1195031 - Putative ribosome bioproteinis GTPase RsgA May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover%3B Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily%3B Contains 1 CP-type G (guanine nucleotide-binding) domain%3B KEGG: wko:WKK_00685 ribosome biogenesis GTPase%3B In phosphorus-containing anhydrides gene gene1151 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01152 WSWS_01153 WSWS_01153 WSWS_01153 1195041 1197155 - Non-specific serine/threonine protein kinase Belongs to the protein kinase superfamily. Ser/Thr protein kinase family%3B Contains 3 PASTA domains%3B Contains 1 protein kinase domain%3B KEGG: ccn:H924_00220 serine/threonine protein kinase%2C bacterial gene gene1152 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01153 WSWS_01154 WSWS_01154 WSWS_01154 1197159 1197899 - Protein-serine/threonine phosphatase Protein phosphatase able to dephosphorylate StkP-P and other phosphorylated protein substrates. PhpP and its cognate protein kinase StkP appear to constitute a functional signaling couple in vivo%2C PhpP's primary role being probably to control phosphorylation levels of StkP and of its targets. PhpP thus performs an essential control of StkP activity (By similarity). Also dephosphorylates DivIVA in vivo%3B Belongs to the PP2C family%3B Contains 1 PPM-type phosphatase domain%3B KEGG: lsa:LSA0691 protein phosphatase gene gene1153 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01154 WSWS_01155 WSWS_01155 WSWS_01155 1197946 1199325 - 16S rRNA (cytosine(967)-C(5))-methyltransferase Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family%3B KEGG: lsn:LSA_06680 16S rRNA (cytosine967-C5)-methyltransferase gene gene1154 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01155 WSWS_01156 WSWS_01156 WSWS_01156 1199318 1200274 - Methionyl-tRNA formyltransferase Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP%3B Belongs to the Fmt family%3B KEGG: sda:GGS_1527 methionyl-tRNA formyltransferase gene gene1155 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01156 WSWS_01157 WSWS_01157 priA priA 1200322 1202754 - Primosomal protein N' Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex%2C via its helicase activity%2C and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA%3B Belongs to the helicase family. PriA subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: btl:BALH_3499 primosomal protein N' (replication factor Y) (superfamily II helicase)%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene1156 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01157 WSWS_01158 WSWS_01158 WSWS_01158 1202904 1204091 - Acetate kinase Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction%3B Belongs to the acetokinase family%3B KEGG: lmo:lmo1581 acetate kinase gene gene1157 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01158 WSWS_01159 WSWS_01159 WSWS_01159 1204218 1205231 - Site-specific DNA-methyltransferase (adenine-specific) KEGG: wko:WKK_00720 site-specific DNA-methyltransferase (adenine-specific) gene gene1158 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01159 WSWS_01160 WSWS_01160 WSWS_01160 1205294 1205488 - hypothetical protein gene gene1159 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01160 WSWS_01161 WSWS_01161 WSWS_01161 1205454 1205954 - hypothetical protein gene gene1160 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01161 WSWS_01162 WSWS_01162 WSWS_01162 1205911 1206153 - hypothetical protein gene gene1161 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01162 WSWS_01163 WSWS_01163 WSWS_01163 1206101 1206502 - hypothetical protein gene gene1162 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01163 WSWS_01164 WSWS_01164 WSWS_01164 1206486 1206830 - ComG operon protein 3 like protein Required for transformation and DNA binding%3B Belongs to the ComGC family gene gene1163 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01164 WSWS_01165 WSWS_01165 WSWS_01165 1206824 1207837 - ComG operon protein 2 like protein Required for transformation and DNA binding%3B Belongs to the GSP F family gene gene1164 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01165 WSWS_01166 WSWS_01166 WSWS_01166 1207824 1208717 - ComG operon protein Required for uptake of DNA by competent cells%3B Belongs to the GSP E family gene gene1165 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01166 WSWS_01167 WSWS_01167 WSWS_01167 1208913 1210364 - Guanine/hypoxanthine permease GhxP High-affinity transporter for guanine and hypoxanthine%3B Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2. A. 1. 40) subfamily gene gene1166 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01167 WSWS_01168 WSWS_01168 WSWS_01168 1210638 1211747 - 5-(carboxyamino)imidazole ribonucleotide synthase Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)%3B Belongs to the PurK/PurT family%3B Contains 1 ATP-grasp domain%3B KEGG: wko:WKK_05580 5-(carboxyamino)imidazole ribonucleotide synthase gene gene1167 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01168 WSWS_01169 WSWS_01169 WSWS_01169 1211760 1212443 - Lysozyme Is the major glucosaminidase responsible for peptidoglycan structural determination during vegetative growth. Acts processively from the ends of the glycan strands. Also plays a role in motility%2C chemotaxis and cell division%3B Belongs to the glycosyl hydrolase 73 family%3B KEGG: lpl:lp_1138 lysozyme gene gene1168 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01169 WSWS_01170 WSWS_01170 WSWS_01170 1212454 1214205 - ATP-binding/permease protein CydD Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system (By similarity)%3B Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3. A. 1. 129. 1) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene1169 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01170 WSWS_01171 WSWS_01171 WSWS_01171 1214192 1215928 - ATP-binding/permease protein CydC Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system (By similarity)%3B Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3. A. 1. 129. 1) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene1170 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01171 WSWS_01172 WSWS_01172 cydB cydB 1215999 1217009 - Cytochrome bd ubiquinol oxidase subunit Belongs to the cytochrome ubiquinol oxidase subunit 2 family%3B KEGG: lpl:lp_1126 cytochrome d ubiquinol oxidase subunit II%3B With oxygen as acceptor%3B overlaps another CDS with the same product name gene gene1171 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01172 WSWS_01173 WSWS_01173 cydA cydA 1217009 1218493 - Cytochrome bd ubiquinol oxidase subunit Belongs to the cytochrome ubiquinol oxidase subunit 1 family%3B KEGG: aci:ACIAD1750 cytochrome d ubiquinol oxidase subunit I%3B With oxygen as acceptor%3B overlaps another CDS with the same product name gene gene1172 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01173 WSWS_01174 WSWS_01174 WSWS_01174 1218860 1219720 - hypothetical protein gene gene1173 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01174 WSWS_01175 WSWS_01175 WSWS_01175 1220156 1220246 - tRNA-Ser tRNA gene1174 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01175 WSWS_01176 WSWS_01176 WSWS_01176 1220272 1220345 - tRNA-Ile tRNA gene1175 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01176 WSWS_01177 WSWS_01177 WSWS_01177 1220350 1220421 - tRNA-Gly tRNA gene1176 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01177 WSWS_01178 WSWS_01178 WSWS_01178 1220452 1220524 - tRNA-Phe tRNA gene1177 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01178 WSWS_01179 WSWS_01179 WSWS_01179 1220533 1220606 - tRNA-Asp tRNA gene1178 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01179 WSWS_01180 WSWS_01180 WSWS_01180 1220610 1220683 - tRNA-Met tRNA gene1179 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01180 WSWS_01181 WSWS_01181 WSWS_01181 1220720 1220809 - tRNA-Ser tRNA gene1180 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01181 WSWS_01182 WSWS_01182 WSWS_01182 1220838 1220911 - tRNA-Met tRNA gene1181 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01182 WSWS_01183 WSWS_01183 WSWS_01183 1220926 1220999 - tRNA-Met tRNA gene1182 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01183 WSWS_01184 WSWS_01184 WSWS_01184 1221035 1221108 - tRNA-Pro tRNA gene1183 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01184 WSWS_01185 WSWS_01185 WSWS_01185 1221141 1221214 - tRNA-Arg tRNA gene1184 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01185 WSWS_01186 WSWS_01186 WSWS_01186 1221223 1221306 - tRNA-Leu tRNA gene1185 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01186 WSWS_01187 WSWS_01187 WSWS_01187 1221309 1221381 - tRNA-Gly tRNA gene1186 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01187 WSWS_01188 WSWS_01188 WSWS_01188 1221389 1221461 - tRNA-Thr tRNA gene1187 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01188 WSWS_01189 WSWS_01189 WSWS_01189 1221498 1221570 - tRNA-Lys tRNA gene1188 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01189 WSWS_01190 WSWS_01190 WSWS_01190 1221573 1221645 - tRNA-Val tRNA gene1189 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01190 WSWS_01191 WSWS_01191 WSWS_01191 1221652 1221768 - 5S ribosomal RNA rRNA gene1190 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01191 WSWS_01192 WSWS_01192 WSWS_01192 1221869 1224785 - 23S ribosomal RNA rRNA gene1191 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01192 WSWS_01193 WSWS_01193 WSWS_01193 1225041 1226617 - 16S ribosomal RNA rRNA gene1192 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01193 WSWS_01194 WSWS_01194 WSWS_01194 1227041 1227424 - hypothetical protein gene gene1193 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01194 WSWS_01195 WSWS_01195 WSWS_01195 1227449 1227835 - Polyribonucleotide nucleotidyltransferase Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction%3B Belongs to the polyribonucleotide nucleotidyltransferase family%3B Contains 1 KH domain%3B Contains 1 S1 motif domain gene gene1194 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01195 WSWS_01196 WSWS_01196 ppiB ppiB 1227904 1228509 - Peptidylprolyl isomerase PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)%3B Belongs to the cyclophilin-type PPIase family%3B Contains 1 PPIase cyclophilin-type domain%3B KEGG: scp:HMPREF0833_12021 peptidyl-prolyl cis-trans isomerase B (cyclophilin B) gene gene1195 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01196 WSWS_01197 WSWS_01197 WSWS_01197 1228635 1229306 + hypothetical protein Belongs to the DedA family gene gene1196 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01197 WSWS_01198 WSWS_01198 WSWS_01198 1229818 1230183 + hypothetical protein gene gene1197 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01198 WSWS_01199 WSWS_01199 rpoZ rpoZ 1230464 1230688 - DNA-directed RNA polymerase Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits%3B Belongs to the RNA polymerase subunit omega family%3B KEGG: bck:BCO26_1077 DNA-directed RNA polymerase subunit omega gene gene1198 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01199 WSWS_01200 WSWS_01200 WSWS_01200 1230685 1231302 - Guanylate kinase Essential for recycling GMP and indirectly%2C cGMP%3B Belongs to the guanylate kinase family%3B Contains 1 guanylate kinase-like domain%3B KEGG: bmq:BMQ_4244 guanylate kinase gene gene1199 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01200 WSWS_01201 WSWS_01201 WSWS_01201 1231355 1232893 - hypothetical protein gene gene1200 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01201 WSWS_01202 WSWS_01202 WSWS_01202 1232999 1234666 - DNA repair protein RecN May be involved in recombinational repair of damaged DNA%3B Belongs to the RecN family gene gene1201 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01202 WSWS_01203 WSWS_01203 WSWS_01203 1234684 1235136 - Arginine repressor Regulates arginine biosynthesis genes%3B Belongs to the ArgR family gene gene1202 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01203 WSWS_01204 WSWS_01204 tlyA tlyA 1235123 1235974 - 23S rRNA (cytidine(1920)-2'-O)-methyltransferase Belongs to the TlyA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: wce:WS08_0902 23S rRNA (cytidine1920-2'-O)/16S rRNA (cytidine1409-2'-O)-methyltransferase gene gene1203 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01204 WSWS_01205 WSWS_01205 ggpS ggpS 1235977 1236837 - Dimethylallyltranstransferase Heterodimeric geranyl(geranyl)-diphosphate (GPP) synthase large subunit. In vitro%2C the large subunit catalyzes mainly the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate while the small subunit alone is inactive. Upon association of the two subunits%2C the product profile changes and the production of gerany-diphosphate is strongly increased%3B Belongs to the FPP/GGPP synthase family%3B KEGG: pln:Plano_1353 geranylgeranyl diphosphate synthase%2C type II gene gene1204 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01205 WSWS_01206 WSWS_01206 xseB xseB 1236834 1237058 - Exodeoxyribonuclease VII Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides%2C which are then degraded further into small acid-soluble oligonucleotides%3B Belongs to the XseB family%3B KEGG: stk:STP_1107 exodeoxyribonuclease VII small subunit%3B overlaps another CDS with the same product name gene gene1205 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01206 WSWS_01207 WSWS_01207 xseA xseA 1237058 1238317 - Exodeoxyribonuclease VII Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides%2C which are then degraded further into small acid-soluble oligonucleotides%3B Belongs to the XseA family%3B KEGG: sau:SA1354 exodeoxyribonuclease VII large subunit%3B overlaps another CDS with the same product name gene gene1206 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01207 WSWS_01208 WSWS_01208 folD folD 1238319 1239182 - Methylenetetrahydrofolate dehydrogenase (NADP(+)) Catalyzes the oxidation of 5%2C10- methylenetetrahydrofolate to 5%2C10-methenyltetrahydrofolate and then the hydrolysis of 5%2C10-methenyltetrahydrofolate to 10- formyltetrahydrofolate%3B Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family%3B KEGG: aci:ACIAD2553 methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase gene gene1207 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01208 WSWS_01209 WSWS_01209 WSWS_01209 1239330 1240151 - hypothetical protein gene gene1208 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01209 WSWS_01210 WSWS_01210 WSWS_01210 1240144 1241847 - Putative ABC transporter ATP-binding protein Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B KEGG: bif:N288_00895 energy-coupling factor transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene1209 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01210 WSWS_01211 WSWS_01211 WSWS_01211 1241920 1242468 - UPF0397 protein Belongs to the UPF0397 family gene gene1210 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01211 WSWS_01212 WSWS_01212 WSWS_01212 1242503 1243345 - 5'-fluoro-5'-deoxy-adenosine synthase Involved in the biosynthesis of fluorometabolites. Catalyzes the formation of a C-F bond by combining S-adenosyl-L- methionine (SAM) and fluoride to generate 5'-fluoro-5'- deoxyadenosine (5'-FDA) and L-methionine. It can also use 2'- deoxyadenosine in place of adenosine as substrate%3B Belongs to the SalL family gene gene1211 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01212 WSWS_01213 WSWS_01213 WSWS_01213 1243669 1244151 - hypothetical protein gene gene1212 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01213 WSWS_01214 WSWS_01214 WSWS_01214 1244164 1246107 - ATP-binding protein ChvD The induction of virG by growth under acidic conditions and by phosphate starvation%2C in the absence of plant inducers%2C is influenced by ChvD. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene1213 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01214 WSWS_01215 WSWS_01215 WSWS_01215 1246229 1246873 - Redox-sensing transcriptional repressor Rex Modulates transcription in response to changes in cellular NADH/NAD(+) redox state%3B Belongs to the transcriptional regulatory Rex family gene gene1214 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01215 WSWS_01216 WSWS_01216 rhlB rhlB 1247075 1248409 - RNA helicase Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily%3B Contains 1 helicase ATP-binding domain%3B KEGG: lil:LA_3435 ATP-dependent RNA helicase RhlB gene gene1215 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01216 WSWS_01217 WSWS_01217 WSWS_01217 1248577 1249572 - putative oxidoreductase YgjR Belongs to the Gfo/Idh/MocA family%3B KEGG: vfi:VF_A0726 null%3B With NAD(+) or NADP(+) as acceptor gene gene1216 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01217 WSWS_01218 WSWS_01218 WSWS_01218 1249678 1249833 - hypothetical protein gene gene1217 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01218 WSWS_01219 WSWS_01219 WSWS_01219 1249928 1252513 - DNA mismatch repair protein MutS This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity%3B Belongs to the DNA mismatch repair MutS family gene gene1218 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01219 WSWS_01220 WSWS_01220 WSWS_01220 1252570 1253112 - hypothetical protein gene gene1219 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01220 WSWS_01221 WSWS_01221 WSWS_01221 1253122 1254300 - UPF0348 protein Belongs to the UPF0348 family gene gene1220 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01221 WSWS_01222 WSWS_01222 WSWS_01222 1254313 1255062 - Putative methyltransferase May be a S-adenosyl-L-methionine (SAM)-dependent methyltransferase. Belongs to the methyltransferase superfamily gene gene1221 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01222 WSWS_01223 WSWS_01223 WSWS_01223 1255077 1255445 - Ribosomal silencing factor RsfS Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN)%2C blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes%2C thus repressing translation%3B Belongs to the Iojap/RsfS family gene gene1222 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01223 WSWS_01224 WSWS_01224 nadD nadD 1255455 1256048 - Nicotinate-nucleotide adenylyltransferase Contains 1 HD domain%3B KEGG: clt:CM240_1495 nicotinate-nucleotide adenylyltransferase%3B overlaps another CDS with the same product name gene gene1223 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01224 WSWS_01225 WSWS_01225 WSWS_01225 1256014 1256688 - Nicotinate-nucleotide adenylyltransferase Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)%3B Belongs to the NadD family%3B KEGG: lcn:C270_06050 nicotinate-nucleotide adenylyltransferase%3B overlaps another CDS with the same product name gene gene1224 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01225 WSWS_01226 WSWS_01226 WSWS_01226 1256727 1257041 - putative RNA-binding protein YqeI Contains 1 CRM domain gene gene1225 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01226 WSWS_01227 WSWS_01227 WSWS_01227 1257043 1258185 - uncharacterized protein Binds GTP and GDP. Belongs to the TRAFAC class YlqF/YawG GTPase family%3B Contains 1 CP-type G (guanine nucleotide-binding) domain%3B overlaps another CDS with the same product name gene gene1226 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01227 WSWS_01228 WSWS_01228 WSWS_01228 1258178 1258705 - uncharacterized protein overlaps another CDS with the same product name gene gene1227 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01228 WSWS_01229 WSWS_01229 WSWS_01229 1259056 1259496 + Spore coat protein SP96 Contains 1 DSCP-N (Dictyostelium spore coat N- terminal) domain%3B Contains 6 follistatin-like domains%3B KEGG: lfe:LAF_1184 penicillin-binding protein 1A%3B Hexosyltransferases gene gene1228 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01229 WSWS_01230 WSWS_01230 WSWS_01230 1259663 1260886 - Phosphoglycerate kinase Belongs to the phosphoglycerate kinase family%3B KEGG: lrf:LAR_0382 phosphoglycerate kinase gene gene1229 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01230 WSWS_01231 WSWS_01231 gapA gapA 1261042 1262061 - Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1%2C3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue%2C and this hemiacetal intermediate is then oxidized to a thioester%2C with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD%2C and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG%3B Belongs to the glyceraldehyde-3-phosphate dehydrogenase family%3B KEGG: wol:WD0451 glyceraldehyde 3-phosphate dehydrogenase gene gene1230 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01231 WSWS_01232 WSWS_01232 WSWS_01232 1262312 1263628 - Glutathione-disulfide reductase Probably involved in reactive chlorine species (RCS) stress resistance%3B Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: cal:CaO19. 11623 glutathione reductase (NADPH) gene gene1231 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01232 WSWS_01233 WSWS_01233 WSWS_01233 1263742 1263813 - tRNA-Arg tRNA gene1232 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01233 WSWS_01234 WSWS_01234 WSWS_01234 1263906 1264361 - hypothetical protein gene gene1233 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01234 WSWS_01235 WSWS_01235 WSWS_01235 1264354 1264704 - Repressor LexA KEGG: saua:SAAG_02515 repressor LexA gene gene1234 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01235 WSWS_01236 WSWS_01236 WSWS_01236 1264903 1265109 + hypothetical protein gene gene1235 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01236 WSWS_01237 WSWS_01237 WSWS_01237 1265154 1266020 - DNA-entry nuclease By degrading DNA that enters the cell%2C plays a role in the competence of cells to be transformed. Belongs to the DNA/RNA non-specific endonuclease family gene gene1236 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01237 WSWS_01238 WSWS_01238 WSWS_01238 1266020 1266397 - hypothetical protein gene gene1237 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01238 WSWS_01239 WSWS_01239 WSWS_01239 1266524 1267852 - Phosphopyruvate hydratase Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis%3B Belongs to the enolase family%3B KEGG: lsl:LSL_1163 enolase gene gene1238 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01239 WSWS_01240 WSWS_01240 WSWS_01240 1267983 1268768 - Triose-phosphate isomerase Belongs to the triosephosphate isomerase family%3B KEGG: asu:Asuc_0677 triosephosphate isomerase (TIM) gene gene1239 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01240 WSWS_01241 WSWS_01241 ptsI ptsI 1268834 1270561 - Phosphoenolpyruvate--protein phosphotransferase General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). Belongs to the PEP-utilizing enzyme family%3B KEGG: slg:SLGD_01791 phosphotransferase system%2C enzyme I%2C PtsI gene gene1240 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01241 WSWS_01242 WSWS_01242 WSWS_01242 1270609 1270875 - Phosphocarrier protein HPr General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III) (By similarity)%3B P-Ser-HPr interacts with the catabolite control protein A (CcpA)%2C forming a complex that binds to DNA at the catabolite response elements cre%2C operator sites preceding a large number of catabolite-regulated genes. Thus%2C P-Ser-HPr is a corepressor in carbon catabolite repression (CCR)%2C a mechanism that allows bacteria to coordinate and optimize the utilization of available carbon sources. P-Ser-HPr also plays a role in inducer exclusion%2C in which it probably interacts with several non-PTS permeases and inhibits their transport activity (By similarity)%3B Belongs to the HPr family%3B Contains 1 HPr domain gene gene1241 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01242 WSWS_01243 WSWS_01243 WSWS_01243 1270989 1271162 - hypothetical protein gene gene1242 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01243 WSWS_01244 WSWS_01244 WSWS_01244 1271289 1272266 - Beta-ketoacyl-[acyl-carrier-protein] synthase III Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids%3B Belongs to the FabH family%3B KEGG: osa:4337178 3-oxoacyl-(acyl-carrier-protein) synthase III gene gene1243 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01244 WSWS_01245 WSWS_01245 trxB trxB 1272424 1273374 - Thioredoxin-disulfide reductase Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: dti:Desti_5141 thioredoxin reductase (NADPH) gene gene1244 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01245 WSWS_01246 WSWS_01246 ugp2 ugp2 1273535 1274410 - UTP--glucose-1-phosphate uridylyltransferase Belongs to the UDPGP type 2 family%3B KEGG: pmr:PMI1490 UTP--glucose-1-phosphate uridylyltransferase gene gene1245 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01246 WSWS_01247 WSWS_01247 gpsA gpsA 1274417 1275436 - Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family%3B KEGG: lok:Loa_02257 glycerol-3-phosphate dehydrogenase (NAD(P)+) gene gene1246 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01247 WSWS_01248 WSWS_01248 hprK hprK 1275542 1276471 - HPr kinase/phosphorylase Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr%2C a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing%2C inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites%2C which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose%2C fructose%2C etc.) in the growth medium. Therefore%2C by controlling the phosphorylation state of HPr%2C HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR)%2C and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion%3B Belongs to the HPrK/P family%3B KEGG: wce:WS08_0189 HPr kinase/phosphorylase%3B Protein-serine/threonine kinases gene gene1247 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01248 WSWS_01249 WSWS_01249 WSWS_01249 1276480 1276848 - uncharacterized protein gene gene1248 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01249 WSWS_01250 WSWS_01250 WSWS_01250 1277537 1277986 + Putative universal stress protein Belongs to the universal stress protein A family gene gene1249 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01250 WSWS_01251 WSWS_01251 WSWS_01251 1278053 1278424 + hypothetical protein gene gene1250 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01251 WSWS_01252 WSWS_01252 WSWS_01252 1278558 1280675 - Elongation factor Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step%2C the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites%2C respectively. Catalyzes the coordinated movement of the two tRNA molecules%2C the mRNA and conformational changes in the ribosome%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene1251 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01252 WSWS_01253 WSWS_01253 WSWS_01253 1280879 1281349 - 30S ribosomal protein S7 One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center%2C probably blocks exit of the E-site tRNA%3B Belongs to the ribosomal protein S7P family gene gene1252 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01253 WSWS_01254 WSWS_01254 WSWS_01254 1281370 1281786 - 30S ribosomal protein S12 With S4 and S5 plays an important role in translational accuracy%3B Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits%2C it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8%2C S12 and S17 appears to hold together the shoulder and platform of the 30S subunit%3B Belongs to the ribosomal protein S12P family gene gene1253 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01254 WSWS_01255 WSWS_01255 WSWS_01255 1282097 1282471 + hypothetical protein gene gene1254 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01255 WSWS_01256 WSWS_01256 WSWS_01256 1282515 1283078 - 50S ribosomal protein L20 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit%3B Belongs to the ribosomal protein L20P family gene gene1255 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01256 WSWS_01257 WSWS_01257 WSWS_01257 1283145 1283342 - 50S ribosomal protein L35 Belongs to the ribosomal protein L35P family gene gene1256 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01257 WSWS_01258 WSWS_01258 WSWS_01258 1283368 1283865 - Translation initiation factor IF-3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits%2C thus enhancing the availability of 30S subunits on which protein synthesis initiation begins%3B Belongs to the IF-3 family gene gene1257 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01258 WSWS_01259 WSWS_01259 WSWS_01259 1284086 1284502 - N utilization substance protein B like protein Involved in the transcription termination process%3B Belongs to the NusB family gene gene1258 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01259 WSWS_01260 WSWS_01260 WSWS_01260 1284502 1284936 - uncharacterized protein Belongs to the asp23 family gene gene1259 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01260 WSWS_01261 WSWS_01261 WSWS_01261 1285029 1285592 - Elongation factor Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA%2C thus increasing their reactivity as acceptors for peptidyl transferase%3B Belongs to the elongation factor P family gene gene1260 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01261 WSWS_01262 WSWS_01262 WSWS_01262 1285735 1287078 - Glucose-6-phosphate isomerase Belongs to the GPI family%3B KEGG: lmu:LBLM1_08770 glucose-6-phosphate isomerase gene gene1261 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01262 WSWS_01263 WSWS_01263 WSWS_01263 1287199 1288233 - Aldose 1-epimerase Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose%2C L-arabinose%2C D-xylose%2C D-galactose%2C maltose and lactose (By similarity)%3B Belongs to the aldose epimerase family%3B KEGG: wko:WKK_05070 aldose 1-epimerase gene gene1262 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01263 WSWS_01264 WSWS_01264 WSWS_01264 1288388 1289350 - Putative sugar uptake protein Belongs to the GRP transporter (TC 2. A. 7. 5) family gene gene1263 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01264 WSWS_01265 WSWS_01265 mtrB mtrB 1289567 1290619 - Histidine kinase Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals. Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 response regulatory domain%3B KEGG: mts:MTES_0527 two-component system%2C OmpR family%2C sensor histidine kinase MtrB gene gene1264 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01265 WSWS_01266 WSWS_01266 WSWS_01266 1290695 1291408 - Transcriptional activator protein CopR Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a specific site on the cop operon promoter (cop box) and possibly by facilitating the binding of RNA polymerase to the cop promoter. CopR also binds to the chromosomally encoded cop operon promoter. May also be involved in basic copper metabolism. Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1265 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01266 WSWS_01267 WSWS_01267 WSWS_01267 1291784 1293250 - putative ABC transporter extracellular-binding protein YckB Probably part of a binding-protein-dependent transport system. Belongs to the bacterial solute-binding protein 3 family gene gene1266 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01267 WSWS_01268 WSWS_01268 WSWS_01268 1293410 1294648 - Cytosine deaminase Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway%2C which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine%2C a mutagenic oxidation product of adenine in DNA%2C and of isocytosine. To a lesser extent%2C also catalyzes the conversion of 5- fluorocytosine (5FC) to 5-fluorouracil (5FU%3B this activity allows the formation of a cytotoxic chemotherapeutic agent from a non- cytotoxic precursor%3B Belongs to the cytosine deaminase family%3B KEGG: rge:RGE_45440 cytosine deaminase gene gene1267 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01268 WSWS_01269 WSWS_01269 topB topB 1294732 1296804 - DNA topoisomerase KEGG: lsl:LSL_1824 DNA topoisomerase III gene gene1268 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01269 WSWS_01270 WSWS_01270 WSWS_01270 1296886 1298448 - Ribonuclease Endoribonuclease that initiates mRNA decay%3B Belongs to the RNase Y family%3B Contains 1 HD domain%3B Contains 1 KH domain%3B KEGG: lmo:lmo1399 ribonucrease Y%3B Acting on ester bonds gene gene1269 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01270 WSWS_01271 WSWS_01271 copB copB 1298652 1300226 - Cu(2+)-exporting ATPase Involved in copper export%3B Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IB subfamily%3B KEGG: wce:WS08_0137 Cu2+-exporting ATPase gene gene1270 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01271 WSWS_01272 WSWS_01272 WSWS_01272 1300359 1300432 - tRNA-Met tRNA gene1271 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01272 WSWS_01273 WSWS_01273 WSWS_01273 1300463 1300552 - tRNA-Ser tRNA gene1272 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01273 WSWS_01274 WSWS_01274 WSWS_01274 1300628 1302772 - Cu(2+)-exporting ATPase Involved in copper transport%3B Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IB subfamily%3B KEGG: lla:L70979 Cu2+-exporting ATPase gene gene1273 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01274 WSWS_01275 WSWS_01275 WSWS_01275 1302850 1303389 + hypothetical protein gene gene1274 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01275 WSWS_01276 WSWS_01276 cryZ cryZ 1303489 1304451 + NADPH:quinone reductase KEGG: bbe:BBR47_15300 NADPH2:quinone reductase gene gene1275 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01276 WSWS_01277 WSWS_01277 WSWS_01277 1304606 1304689 - tRNA-Leu tRNA gene1276 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01277 WSWS_01278 WSWS_01278 WSWS_01278 1304834 1305355 - hypothetical protein gene gene1277 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01278 WSWS_01279 WSWS_01279 WSWS_01279 1305570 1306031 - SsrA-binding protein Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA)%2C required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape%2C replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gen%3B the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide'%2C a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA%2C entering the A-site of stalled ribosomes%2C displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRN%3B the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation%2C which seems to be the essential function of trans- translation%3B Belongs to the SmpB family gene gene1278 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01279 WSWS_01280 WSWS_01280 vacB vacB 1306052 1308385 - Ribonuclease R 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs%3B Belongs to the RNR ribonuclease family. RNase R subfamily%3B Contains 1 S1 motif domain%3B KEGG: lbh:Lbuc_1311 ribonuclease R%3B Acting on ester bonds gene gene1279 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01280 WSWS_01281 WSWS_01281 WSWS_01281 1308645 1308881 - putative protein-export membrane protein SecG Involved in protein export. Participates in an early event of protein translocation (By similarity)%3B Belongs to the SecG family gene gene1280 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01281 WSWS_01282 WSWS_01282 WSWS_01282 1308965 1309735 - 4-nitrophenylphosphatase Belongs to the HAD-like hydrolase superfamily. NagD family%3B KEGG: bha:BH3428 4-nitrophenyl phosphatase gene gene1281 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01282 WSWS_01283 WSWS_01283 WSWS_01283 1309739 1310311 - uncharacterized protein gene gene1282 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01283 WSWS_01284 WSWS_01284 WSWS_01284 1310329 1311705 - 5'-nucleotidase Belongs to the metallophosphoesterase superfamily%3B KEGG: ldb:Ldb1591 5'-nucleotidase gene gene1283 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01284 WSWS_01285 WSWS_01285 WSWS_01285 1311709 1312329 - hypothetical protein gene gene1284 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01285 WSWS_01286 WSWS_01286 WSWS_01286 1312361 1312804 - hypothetical protein gene gene1285 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01286 WSWS_01287 WSWS_01287 pepP pepP 1312809 1313888 - Xaa-Pro aminopeptidase Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides%3B Belongs to the peptidase M24B family%3B KEGG: lmu:LBLM1_03475 Xaa-Pro aminopeptidase gene gene1286 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01287 WSWS_01288 WSWS_01288 menC menC 1313941 1315053 - o-succinylbenzoate synthase KEGG: wce:WS08_0958 O-succinylbenzoate synthase gene gene1287 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01288 WSWS_01289 WSWS_01289 menH menH 1314998 1315795 - 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1-carboxylate synthase Catalyzes a proton abstraction reaction that results in 2%2C5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1-carboxylate (SHCHC)%3B Belongs to the AB hydrolase superfamily. MenH family%3B KEGG: aac:Aaci_1917 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1-carboxylate synthase gene gene1288 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01289 WSWS_01290 WSWS_01290 menD menD 1315788 1317458 - 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acidsynthase Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)%3B Belongs to the TPP enzyme family. MenD subfamily%3B KEGG: lgn:ABM34_02195 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase gene gene1289 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01290 WSWS_01291 WSWS_01291 menF menF 1317451 1318605 - Isochorismate synthase Catalyzes the conversion of chorismate to isochorismate%3B Belongs to the isochorismate synthase family%3B KEGG: wce:WS08_0961 menaquinone-specific isochorismate synthase gene gene1290 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01291 WSWS_01292 WSWS_01292 WSWS_01292 1318873 1319322 - uncharacterized protein gene gene1291 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01292 WSWS_01293 WSWS_01293 WSWS_01293 1319672 1320211 - Inner membrane protein gene gene1292 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01293 WSWS_01294 WSWS_01294 WSWS_01294 1320522 1320863 + hypothetical protein gene gene1293 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01294 WSWS_01295 WSWS_01295 WSWS_01295 1320946 1321257 - 50S ribosomal protein L27 Belongs to the ribosomal protein L27P family gene gene1294 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01295 WSWS_01296 WSWS_01296 WSWS_01296 1321284 1321586 - 50S ribosomal protein L21 This protein binds to 23S rRNA in the presence of protein L20%3B Belongs to the ribosomal protein L21P family gene gene1295 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01296 WSWS_01297 WSWS_01297 WSWS_01297 1321747 1322313 - hypothetical protein gene gene1296 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01297 WSWS_01298 WSWS_01298 WSWS_01298 1322380 1322451 + tRNA-Arg tRNA gene1297 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01298 WSWS_01299 WSWS_01299 WSWS_01299 1322604 1323341 - 3-oxoacyl-[acyl-carrier-protein] reductase Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor%2C but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings%2C such as pyrimidine-4-aldehyde%2C 3-benzoylpyridine%2C 4-benzoylpyridine%2C menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity)%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: lpl:lp_2764 3-oxoacyl-(acyl-carrier protein) reductase gene gene1298 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01299 WSWS_01300 WSWS_01300 WSWS_01300 1323343 1323894 - hypothetical protein gene gene1299 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01300 WSWS_01301 WSWS_01301 WSWS_01301 1324000 1324500 - hypothetical protein gene gene1300 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01301 WSWS_01302 WSWS_01302 WSWS_01302 1324500 1325492 - hypothetical protein gene gene1301 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01302 WSWS_01303 WSWS_01303 WSWS_01303 1325485 1326378 - hypothetical protein gene gene1302 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01303 WSWS_01304 WSWS_01304 glnA glnA 1326551 1327897 - Glutamate--ammonia ligase Belongs to the glutamine synthetase family%3B KEGG: oih:OB1651 glutamine synthetase gene gene1303 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01304 WSWS_01305 WSWS_01305 WSWS_01305 1327923 1328267 - HTH-type transcriptional regulator Repressor for the glnRA operon. Binds specifically to the promoter region of the glnRA operon (By similarity)%3B Contains 1 HTH merR-type DNA-binding domain gene gene1304 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01305 WSWS_01306 WSWS_01306 miaA miaA 1328339 1329259 - tRNA dimethylallyltransferase Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine%2C leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)%3B Belongs to the IPP transferase family%3B KEGG: saz:Sama_3026 tRNA dimethylallyltransferase gene gene1305 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01306 WSWS_01307 WSWS_01307 WSWS_01307 1329394 1329576 + hypothetical protein gene gene1306 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01307 WSWS_01308 WSWS_01308 WSWS_01308 1329618 1329998 - uncharacterized protein Contains 1 rhodanese domain gene gene1307 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01308 WSWS_01309 WSWS_01309 WSWS_01309 1330098 1331051 - putative serine-rich protein gene gene1308 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01309 WSWS_01310 WSWS_01310 WSWS_01310 1331368 1332348 - Glucokinase Belongs to the ROK (NagC/XylR) family%3B KEGG: ooe:OEOE_0920 glucokinase gene gene1309 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01310 WSWS_01311 WSWS_01311 WSWS_01311 1332522 1332737 - hypothetical protein gene gene1310 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01311 WSWS_01312 WSWS_01312 gluP gluP 1332740 1333441 - Rhomboid protease Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter%3B Belongs to the peptidase S54 family%3B Contains 2 TPR repeats%3B KEGG: lcn:C270_02920 rhomboid protease GluP gene gene1311 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01312 WSWS_01313 WSWS_01313 WSWS_01313 1333425 1333991 - 5-formyltetrahydrofolate cyclo-ligase Belongs to the 5-formyltetrahydrofolate cyclo-ligase family%3B KEGG: tap:GZ22_09200 5-formyltetrahydrofolate cyclo-ligase gene gene1312 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01313 WSWS_01314 WSWS_01314 penA penA 1334103 1336163 - Penicillin-binding protein 2B Belongs to the transpeptidase family%3B KEGG: spn:SP_1673 penicillin-binding protein 2B%3B Aminoacyltransferases gene gene1313 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01314 WSWS_01315 WSWS_01315 WSWS_01315 1336336 1336836 - Transcription elongation factor GreA Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through%2C resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides%3B Belongs to the GreA/GreB family gene gene1314 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01315 WSWS_01316 WSWS_01316 WSWS_01316 1336918 1339578 - hypothetical protein gene gene1315 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01316 WSWS_01317 WSWS_01317 WSWS_01317 1339827 1340501 - Phosphate-specific transport system accessory protein PhoU like protein Plays a role in the regulation of phosphate uptake%3B Belongs to the PhoU family gene gene1316 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01317 WSWS_01318 WSWS_01318 pstB pstB 1340512 1341270 - Phosphate-transporting ATPase Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphate importer (TC 3. A. 1. 7) family%3B Contains 1 ABC transporter domain%3B KEGG: mmt:Metme_1112 phosphate transport system ATP-binding protein gene gene1317 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01318 WSWS_01319 WSWS_01319 WSWS_01319 1341281 1342105 - Phosphate-transporting ATPase Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphate importer (TC 3. A. 1. 7) family%3B Contains 1 ABC transporter domain%3B KEGG: wko:WKK_04900 phosphate transport system ATP-binding protein gene gene1318 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01319 WSWS_01320 WSWS_01320 WSWS_01320 1342138 1343031 - putative ABC transporter permease protein YqgI Part of the binding-protein-dependent transport system YqgGHIJK. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1319 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01320 WSWS_01321 WSWS_01321 WSWS_01321 1343034 1343951 - Phosphate transport system permease protein PstC Part of the binding-protein-dependent transport system for phosphat%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1320 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01321 WSWS_01322 WSWS_01322 WSWS_01322 1343972 1344844 - Phosphate-binding protein PstS Part of the ABC transporter complex PstSACB involved in phosphate import%3B Belongs to the PstS family gene gene1321 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01322 WSWS_01323 WSWS_01323 WSWS_01323 1345017 1346438 - Succinyl-diaminopimelate desuccinylase Belongs to the peptidase M20A family%3B KEGG: sep:SE1424 succinyl-diaminopimelate desuccinylase gene gene1322 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01323 WSWS_01324 WSWS_01324 WSWS_01324 1346561 1347517 - hypothetical protein gene gene1323 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01324 WSWS_01325 WSWS_01325 nrtC nrtC 1347689 1349674 - Lipoprotein-releasing system ATP-binding protein LolD Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins%2C from the inner membrane to the periplasmic chaperone%2C LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner%3B Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3. A. 1. 125) family%3B Contains 1 ABC transporter domain%3B KEGG: vpd:VAPA_1c36330 nitrate/nitrite transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene1324 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01325 WSWS_01326 WSWS_01326 WSWS_01326 1349843 1350481 + hypothetical protein gene gene1325 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01326 WSWS_01327 WSWS_01327 WSWS_01327 1350565 1350636 - tRNA-Glu tRNA gene1326 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01327 WSWS_01328 WSWS_01328 proC proC 1350711 1351502 - Pyrroline-5-carboxylate reductase Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline%3B Belongs to the pyrroline-5-carboxylate reductase family%3B KEGG: cpc:Cpar_1985 pyrroline-5-carboxylate reductase gene gene1327 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01328 WSWS_01329 WSWS_01329 WSWS_01329 1351561 1352748 - Rod shape-determining protein RodA Required for the maintenance of the rod cell shape. Also essential for the elongation of the lateral wall of the cell%3B Belongs to the SEDS family. RodA subfamily gene gene1328 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01329 WSWS_01330 WSWS_01330 WSWS_01330 1352781 1352990 - hypothetical protein gene gene1329 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01330 WSWS_01331 WSWS_01331 WSWS_01331 1353007 1353984 - MreB-like protein Belongs to the FtsA/MreB family gene gene1330 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01331 WSWS_01332 WSWS_01332 murF murF 1354140 1355510 + UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide%2C the precursor of murein%3B Belongs to the MurCDEF family. MurF subfamily%3B KEGG: ljo:LJ0269 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase gene gene1331 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01332 WSWS_01333 WSWS_01333 WSWS_01333 1355557 1356216 - Cell division ATP-binding protein FtsE Part of the ABC transporter FtsEX involved in cellular division. Has ATPase activity%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene1332 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01333 WSWS_01334 WSWS_01334 WSWS_01334 1356237 1357670 - putative ABC transporter permease YclI Belongs to the ABC-4 integral membrane protein family gene gene1333 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01334 WSWS_01335 WSWS_01335 WSWS_01335 1357898 1358854 - putative ABC transporter permease protein YufQ Part of the binding-protein-dependent transport system. Probably responsible for the translocation of the substrates across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family gene gene1334 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01335 WSWS_01336 WSWS_01336 WSWS_01336 1358857 1359975 - putative ABC transporter permease protein YufP Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily gene gene1335 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01336 WSWS_01337 WSWS_01337 potA potA 1359968 1361533 - Polyamine-transporting ATPase Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3. A. 1. 2. 3) family%3B Contains 2 ABC transporter domains%3B KEGG: mbc:MYB_00840 spermidine/putrescine transport system ATP-binding protein gene gene1336 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01337 WSWS_01338 WSWS_01338 pgaM pgaM 1361927 1362637 - Phosphoglycerate mutase (2%2C3-diphosphoglycerate-dependent) Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate%3B Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily%3B KEGG: eco:b0755 2%2C3-bisphosphoglycerate-dependent phosphoglycerate mutase gene gene1337 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01338 WSWS_01339 WSWS_01339 WSWS_01339 1362742 1363755 - Thioredoxin-disulfide reductase Belongs to the ferredoxin--NADP reductase type 2 family%3B KEGG: rpj:N234_05650 thioredoxin reductase (NADPH) gene gene1338 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01339 WSWS_01340 WSWS_01340 WSWS_01340 1363890 1365062 - UPF0755 protein YrrL Belongs to the UPF0755 family gene gene1339 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01340 WSWS_01341 WSWS_01341 pheT pheT 1365210 1367633 - Phenylalanine--tRNA ligase Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily%3B Contains 1 B5 domain%3B Contains 1 FDX-ACB domain%3B Contains 1 tRNA-binding domain%3B KEGG: tkm:TK90_0917 phenylalanyl-tRNA synthetase beta chain gene gene1340 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01341 WSWS_01342 WSWS_01342 pheS pheS 1367637 1368677 - Phenylalanine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily%3B KEGG: rpj:N234_06675 phenylalanyl-tRNA synthetase alpha chain gene gene1341 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01342 WSWS_01343 WSWS_01343 gltX gltX 1368969 1370468 - Glutamate--tRNA(Gln) ligase Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: wko:WKK_04640 nondiscriminating glutamyl-tRNA synthetase gene gene1342 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01343 WSWS_01344 WSWS_01344 WSWS_01344 1370575 1371687 - putative PIN and TRAM-domain containing protein YacL An RNase%3B Belongs to the ycf81 family%3B In the central sectio%3B belongs to the PINc/VapC protein family%3B Contains 1 PINc domain%3B Contains 1 TRAM domain gene gene1343 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01344 WSWS_01345 WSWS_01345 WSWS_01345 1371706 1373076 - DNA repair protein RadA like protein May play a role in the repair of endogenous alkylation damage%3B Belongs to the RecA family. RadA subfamily gene gene1344 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01345 WSWS_01346 WSWS_01346 WSWS_01346 1373076 1373612 - dUTP diphosphatase This enzyme is involved in nucleotide metabolism: it produces dUMP%2C the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA%3B Belongs to the dUTPase family%3B KEGG: lpl:lp_0604 dUTP pyrophosphatase gene gene1345 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01346 WSWS_01347 WSWS_01347 WSWS_01347 1373730 1374029 - hypothetical protein gene gene1346 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01347 WSWS_01348 WSWS_01348 WSWS_01348 1374029 1374577 - Gamma-DL-glutamyl hydrolase Cleaves%2C in an endo-type manner%2C the gamma-glutamyl bond between D-glutamate and L-glutamate of poly-gamma-glutamate (PGA). Belongs to the peptidase C40 family gene gene1347 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01348 WSWS_01349 WSWS_01349 WSWS_01349 1374716 1375567 - putative N-acetylmuramidase Required for cell separation during growth%3B Belongs to the glycosyl hydrolase 73 family%3B Contains 3 LysM repeats gene gene1348 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01349 WSWS_01350 WSWS_01350 WSWS_01350 1376045 1378123 - ATP-dependent Clp protease ATP-binding subunit ClpE Could be necessary for degrading proteins generated by certain types of stress%3B Belongs to the ClpA/ClpB family. ClpE subfamily%3B Contains 1 UVR domain gene gene1349 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01350 WSWS_01351 WSWS_01351 WSWS_01351 1378421 1379434 + NADPH:quinone reductase Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily%3B KEGG: xsa:SB85_07955 NADPH2:quinone reductase gene gene1350 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01351 WSWS_01352 WSWS_01352 WSWS_01352 1379505 1379675 - 50S ribosomal protein L32-2 Belongs to the ribosomal protein L32P family gene gene1351 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01352 WSWS_01353 WSWS_01353 WSWS_01353 1379988 1380443 + hypothetical protein gene gene1352 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01353 WSWS_01354 WSWS_01354 WSWS_01354 1380518 1380589 + tRNA-Gln tRNA gene1353 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01354 WSWS_01355 WSWS_01355 WSWS_01355 1380725 1381873 - hypothetical protein gene gene1354 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01355 WSWS_01356 WSWS_01356 WSWS_01356 1382097 1383098 - D-lactate dehydrogenase Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B KEGG: lgn:ABM34_10655 D-lactate dehydrogenase gene gene1355 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01356 WSWS_01357 WSWS_01357 WSWS_01357 1383438 1384031 - Endopeptidase Clp Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins%3B Belongs to the peptidase S14 family%3B KEGG: lpl:lp_0786 ATP-dependent Clp protease%2C protease subunit gene gene1356 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01357 WSWS_01358 WSWS_01358 WSWS_01358 1384086 1385039 - Putative sporulation transcription regulator WhiA May be required for sporulation%3B Belongs to the WhiA transcriptional regulatory family gene gene1357 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01358 WSWS_01359 WSWS_01359 WSWS_01359 1385056 1386054 - Gluconeoproteinis factor Required for morphogenesis under gluconeogenic growth conditions%3B Belongs to the gluconeogenesis factor family gene gene1358 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01359 WSWS_01360 WSWS_01360 WSWS_01360 1386051 1386947 - Nucleotide-binding protein Displays ATPase and GTPase activities%3B Belongs to the RapZ-like family gene gene1359 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01360 WSWS_01361 WSWS_01361 WSWS_01361 1387049 1388737 - Xylan 1%2C4-beta-xylosidase Beta-1%2C3-xylosidase that hydrolyzes beta-1%2C3- xylooligosaccharides to D-xylose%3B Belongs to the glycosyl hydrolase 43 family%3B KEGG: pzu:PHZ_c2463 xylan 1%2C4-beta-xylosidase gene gene1360 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01361 WSWS_01362 WSWS_01362 WSWS_01362 1388927 1389832 - hypothetical protein gene gene1361 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01362 WSWS_01363 WSWS_01363 murM murM 1389945 1390961 - UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase Involved in the synthesis of the bacterial cell wall. Catalyzes the addition of alanine into the interchain peptide bridge of peptidoglycan precursor using aminoacyl-tRNA(Ala) as amino acid donor. This alanine is added to the epsilon-amino group of the L-lysine of the peptidoglycan UDP-N-acetyl-alpha-D- muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine%2C in a ribosome-independent mechanism (PubMed:11083873%2C PubMed:4248527%2C PubMed:12679335%2C PubMed:15901708%2C PubMed:23744707). Specific for UDP-N-acetyl-muramoyl-pentapeptide. Has no activity toward UDP-N- acetyl-muramoyl-tetrapeptide or UDP-N-acetyl-muramoyl-tripeptide (PubMed:15901708). Also acts on L-seryl-tRNA(Ser) (PubMed:4248527)%3B Belongs to the FemABX family%3B KEGG: lpk:LACPI_0939 serine/alanine adding enzyme gene gene1362 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01363 WSWS_01364 WSWS_01364 WSWS_01364 1391092 1392207 - Peptide chain release factor Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA%3B Belongs to the prokaryotic/mitochondrial release factor family gene gene1363 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01364 WSWS_01365 WSWS_01365 WSWS_01365 1392281 1394650 - Protein translocase subunit SecA Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane%2C serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane%3B Belongs to the SecA family gene gene1364 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01365 WSWS_01366 WSWS_01366 WSWS_01366 1395011 1395856 + ADP-dependent NAD(P)H-hydrate dehydratase Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP%2C which is converted to AMP. Together with NAD(P)HX epimerase%2C which catalyzes the epimerization of the S- and R-forms%2C the enzyme allows the repair of both epimers of NAD(P)HX%2C a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration%3B Belongs to the NnrD/CARKD family%3B Contains 1 YjeF C-terminal domain%3B KEGG: hcs:FF32_17820 ADP-dependent NAD(P)H-hydrate dehydratase gene gene1365 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01366 WSWS_01367 WSWS_01367 WSWS_01367 1395922 1396629 - hypothetical protein gene gene1366 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01367 WSWS_01368 WSWS_01368 WSWS_01368 1396632 1397984 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopimelate ligase KEGG: wko:WKK_02940 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopimelate ligase gene gene1367 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01368 WSWS_01369 WSWS_01369 manA manA 1398116 1399084 - Mannose-6-phosphate isomerase Belongs to the mannose-6-phosphate isomerase type 1 family%3B KEGG: bha:BH3916 mannose-6-phosphate isomerase gene gene1368 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01369 WSWS_01370 WSWS_01370 WSWS_01370 1399233 1399955 - Mannose-6-phosphate isomerase KEGG: wko:WKK_03240 mannose-6-phosphate isomerase gene gene1369 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01370 WSWS_01371 WSWS_01371 WSWS_01371 1400206 1400277 + tRNA-Asn tRNA gene1370 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01371 WSWS_01372 WSWS_01372 WSWS_01372 1400312 1400383 + tRNA-Asn tRNA gene1371 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01372 WSWS_01373 WSWS_01373 WSWS_01373 1400418 1400492 + tRNA-Asn tRNA gene1372 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01373 WSWS_01374 WSWS_01374 msbA msbA 1400533 1402329 - Lipid A export ATP-binding/permease protein MsbA Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation%3B Belongs to the ABC transporter superfamily. Lipid exporter (TC 3. A. 1. 106) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain%3B KEGG: lki:LKI_02170 ATP-binding cassette%2C subfamily B%2C bacterial MsbA%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene1373 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01374 WSWS_01375 WSWS_01375 WSWS_01375 1402489 1403769 - GTPase HflX GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family%3B Contains 1 Hflx-type G (guanine nucleotide-binding) domain gene gene1374 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01375 WSWS_01376 WSWS_01376 WSWS_01376 1403775 1404446 - Phosphoglycerate mutase (2%2C3-diphosphoglycerate-independent) Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate%3B Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily%3B KEGG: lrm:LRC_18300 probable phosphoglycerate mutase gene gene1375 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01376 WSWS_01377 WSWS_01377 WSWS_01377 1405203 1406768 - RNA helicase DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions%2C has RNA- dependent ATPase activity (By similarity). Over-expression leads to cell aggregation%3B Belongs to the DEAD box helicase family. CshA subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: wbr:WGLp221 ATP-dependent RNA helicase DeaD gene gene1376 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01377 WSWS_01378 WSWS_01378 murA murA 1407011 1408276 - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine%3B Belongs to the EPSP synthase family. MurA subfamily%3B KEGG: mbs:MRBBS_2685 UDP-N-acetylglucosamine 1-carboxyvinyltransferase gene gene1377 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01378 WSWS_01379 WSWS_01379 WSWS_01379 1408524 1409171 - putative DNA-directed RNA polymerase subunit delta Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit%2C RNAP displays an increased specificity of transcription%2C a decreased affinity for nucleic acids%2C and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)%3B Belongs to the RpoE family gene gene1378 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01379 WSWS_01380 WSWS_01380 WSWS_01380 1409229 1410044 - Putative phosphatase Belongs to the HAD-like hydrolase superfamily. Cof family gene gene1379 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01380 WSWS_01381 WSWS_01381 WSWS_01381 1410041 1411396 - uncharacterized protein Contains 1 HD domain gene gene1380 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01381 WSWS_01382 WSWS_01382 WSWS_01382 1411497 1411937 + hypothetical protein gene gene1381 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01382 WSWS_01383 WSWS_01383 degP degP 1412351 1413628 - Peptidase Do Degrades abnormal exported proteins and responsible for the propeptide processing of a natural pro-protein and for the maturation of a native protein. It also plays a prominent role in stress (heat shock%2C ethanol%2C puromycin and NaCl) resistance during active exponential growth (By similarity)%3B Belongs to the peptidase S1C family%3B Contains 1 PDZ (DHR) domain%3B KEGG: lpk:LACPI_2239 serine protease Do gene gene1382 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01383 WSWS_01384 WSWS_01384 WSWS_01384 1413718 1414515 - 7%2C8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene5'-phosphate synthase Belongs to the metallo-beta-lactamase superfamily%3B KEGG: tko:TK0735 7%2C8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase gene gene1383 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01384 WSWS_01385 WSWS_01385 WSWS_01385 1414585 1415400 - hypothetical protein gene gene1384 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01385 WSWS_01386 WSWS_01386 WSWS_01386 1415397 1416731 - hypothetical protein gene gene1385 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01386 WSWS_01387 WSWS_01387 vicK vicK 1416721 1418598 - Histidine kinase Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon%2C the yocH and ykvT%2C cwlO%2C lytE%2C ydjM%2C yjeA%2C yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: lrm:LRC_00410 two-component system%2C OmpR family%2C sensor histidine kinase VicK gene gene1386 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01387 WSWS_01388 WSWS_01388 WSWS_01388 1418681 1419385 - Response regulator ArlR Member of the two-component regulatory system ArlS/ArlR%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1387 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01388 WSWS_01389 WSWS_01389 WSWS_01389 1419636 1419708 + tRNA-Lys tRNA gene1388 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01389 WSWS_01390 WSWS_01390 pepO pepO 1419789 1421678 - Putative zinc metalloproteinase in scaA 5'region Belongs to the peptidase M13 family%3B KEGG: smu:SMU_2036 putative endopeptidase%3B Metalloendopeptidases gene gene1389 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01390 WSWS_01391 WSWS_01391 WSWS_01391 1421874 1422044 + hypothetical protein gene gene1390 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01391 WSWS_01392 WSWS_01392 WSWS_01392 1422122 1422259 - hypothetical protein gene gene1391 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01392 WSWS_01393 WSWS_01393 WSWS_01393 1422358 1422615 - hypothetical protein gene gene1392 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01393 WSWS_01394 WSWS_01394 WSWS_01394 1422615 1423214 - Recombination protein RecR May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO%3B Belongs to the RecR family%3B Contains 1 Toprim domain gene gene1393 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01394 WSWS_01395 WSWS_01395 WSWS_01395 1423260 1423568 - Nucleoid-associated protein Binds to DNA and alters its conformation. May be involved in regulation of gene expression%2C nucleoid organization and DNA protection%3B Belongs to the YbaB/EbfC family gene gene1394 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01395 WSWS_01396 WSWS_01396 dnaX dnaX 1423582 1425312 - DNA-directed DNA polymerase DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. Belongs to the DnaX/STICHEL family%3B KEGG: bsu:BSU00190 DNA polymerase III subunit gamma/tau gene gene1395 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01396 WSWS_01397 WSWS_01397 WSWS_01397 1425661 1427130 - Di-/tripeptide transporter Proton-dependent uptake of di- or tri-peptides. Belongs to the PTR2/POT transporter (TC 2. A. 17) family gene gene1396 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01397 WSWS_01398 WSWS_01398 WSWS_01398 1427344 1427862 - Cytosine deaminase Deaminates adenosines to inosines in tRNA-Arg(ACG). Exclusively involved in A-to-I editing of the prokaryote-type chloroplast-tRNA and not involved in C-to-U editing%3B Belongs to the cytidine and deoxycytidylate deaminase family%3B Contains 1 CMP/dCMP-type deaminase domain%3B KEGG: nma:NMA1129 cytosine deaminase gene gene1397 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01398 WSWS_01399 WSWS_01399 rsmC rsmC 1427840 1428460 - 16S rRNA (guanine(1207)-N(2))-methyltransferase Belongs to the methyltransferase superfamily%3B KEGG: lmo:lmo0256 16S rRNA (guanine1207-N2)-methyltransferase gene gene1398 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01399 WSWS_01400 WSWS_01400 WSWS_01400 1428634 1429599 - hypothetical protein gene gene1399 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01400 WSWS_01401 WSWS_01401 WSWS_01401 1429740 1431542 - hypothetical protein gene gene1400 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01401 WSWS_01402 WSWS_01402 WSWS_01402 1431724 1432137 - hypothetical protein gene gene1401 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01402 WSWS_01403 WSWS_01403 WSWS_01403 1432312 1432782 - hypothetical protein gene gene1402 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01403 WSWS_01404 WSWS_01404 WSWS_01404 1432797 1433642 - 23S rRNA (guanine(745)-N(1))-methyltransferase Belongs to the methyltransferase superfamily. RlmA family%3B KEGG: wce:WS08_1120 23S rRNA (guanine745-N1)-methyltransferase gene gene1403 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01404 WSWS_01405 WSWS_01405 WSWS_01405 1433714 1435063 - hypothetical protein gene gene1404 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01405 WSWS_01406 WSWS_01406 WSWS_01406 1435108 1435782 - Phosphonates import ATP-binding protein PhnC Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3. A. 1. 9. 1) family%3B Contains 1 ABC transporter domain gene gene1405 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01406 WSWS_01407 WSWS_01407 WSWS_01407 1435763 1436689 - putative heme-iron transport system permease protein IsdF Part of the binding-protein-dependent transport system for heme-iron. Responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily gene gene1406 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01407 WSWS_01408 WSWS_01408 WSWS_01408 1436673 1437536 - High-affinity heme uptake system protein IsdE Involved in heme (porphyrin) scavenging. Binds Fe(2+) and Fe(3+) heme but the largest fraction is Fe(2+) heme. Functions as a high-affinity heme binding protein and probably has a role in relaying heme-iron from cell wall-anchored isd proteins receptors to the probable permease IsdF (By similarity)%3B Belongs to the bacterial solute-binding protein 8 family%3B Contains 1 Fe/B12 periplasmic-binding domain gene gene1407 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01408 WSWS_01409 WSWS_01409 WSWS_01409 1437529 1438374 - Serine-rich adhesin for platelets Mediates binding to human platelets%2C possibly through a receptor-ligand interaction%3B Belongs to the SraP family gene gene1408 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01409 WSWS_01410 WSWS_01410 WSWS_01410 1438376 1439671 - Chitinase KEGG: ctp:CTRG_05827 chitinase gene gene1409 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01410 WSWS_01411 WSWS_01411 WSWS_01411 1439894 1440397 + Ribosome maturation factor RimM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit%2C possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes%3B Belongs to the RimM family%3B Contains 1 PRC barrel domain gene gene1410 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01411 WSWS_01412 WSWS_01412 trmD trmD 1440399 1441133 + tRNA (guanine(37)-N(1))-methyltransferase Specifically methylates guanosine-37 in various tRNAs%3B Belongs to the RNA methyltransferase TrmD family%3B KEGG: eat:EAT1b_2895 tRNA (guanine37-N1)-methyltransferase gene gene1411 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01412 WSWS_01413 WSWS_01413 WSWS_01413 1441239 1441952 - hypothetical protein gene gene1412 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01413 WSWS_01414 WSWS_01414 ilvE ilvE 1442074 1443108 - Branched-chain-amino-acid transaminase Acts on leucine%2C isoleucine and valine%3B Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: lci:LCK_01024 branched-chain amino acid aminotransferase gene gene1413 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01414 WSWS_01415 WSWS_01415 WSWS_01415 1443260 1444483 - hypothetical protein gene gene1414 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01415 WSWS_01416 WSWS_01416 WSWS_01416 1444880 1446202 - Glutathione-disulfide reductase Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: mfu:LILAB_19285 glutathione reductase (NADPH) gene gene1415 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01416 WSWS_01417 WSWS_01417 WSWS_01417 1446396 1446806 - Putative HTH-type transcriptional regulator YwnA Contains 1 HTH rrf2-type DNA-binding domain gene gene1416 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01417 WSWS_01418 WSWS_01418 qorB qorB 1446889 1447728 - NAD(P)H dehydrogenase (quinone) Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth%3B Belongs to the NmrA-type oxidoreductase family%3B KEGG: ddc:Dd586_2051 NAD(P)H dehydrogenase (quinone) gene gene1417 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01418 WSWS_01419 WSWS_01419 WSWS_01419 1447785 1448360 - hypothetical protein gene gene1418 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01419 WSWS_01420 WSWS_01420 WSWS_01420 1448519 1449133 - NADH:ubiquinone reductase (H(+)-translocating) KEGG: mgm:Mmc1_0977 NADH dehydrogenase gene gene1419 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01420 WSWS_01421 WSWS_01421 WSWS_01421 1449272 1449913 - hypothetical protein gene gene1420 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01421 WSWS_01422 WSWS_01422 WSWS_01422 1449939 1450994 - hypothetical protein gene gene1421 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01422 WSWS_01423 WSWS_01423 WSWS_01423 1451198 1451281 - tRNA-Leu tRNA gene1422 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01423 WSWS_01424 WSWS_01424 WSWS_01424 1451322 1451405 - tRNA-Leu tRNA gene1423 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01424 WSWS_01425 WSWS_01425 WSWS_01425 1451439 1451511 - tRNA-His tRNA gene1424 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01425 WSWS_01426 WSWS_01426 WSWS_01426 1451524 1451594 - tRNA-Trp tRNA gene1425 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01426 WSWS_01427 WSWS_01427 WSWS_01427 1451626 1451698 - tRNA-Phe tRNA gene1426 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01427 WSWS_01428 WSWS_01428 WSWS_01428 1451704 1451777 - tRNA-Asp tRNA gene1427 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01428 WSWS_01429 WSWS_01429 WSWS_01429 1451780 1451852 - tRNA-Val tRNA gene1428 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01429 WSWS_01430 WSWS_01430 WSWS_01430 1452216 1452286 + tRNA-Cys tRNA gene1429 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01430 WSWS_01431 WSWS_01431 tagE tagE 1452338 1453849 - Poly(glycerol-phosphate) alpha-glucosyltransferase An N-acetylglucosaminyl transferase that is part of the accessory SecA2/SecY2 system specifically required to export GspB%2C a serine-rich repeat cell wall protein usually encoded upstream in the same operon. Required for correct glycosylation of GspB. Upon coexpression in E. coli with Gtf2 (GtfB) glycosylates GspB constructs. Glycosylation probably occurs intracellularly%3B Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: lla:L78550 poly(glycerol-phosphate) alpha-glucosyltransferase gene gene1430 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01431 WSWS_01432 WSWS_01432 WSWS_01432 1453864 1455468 - Poly(glycerol-phosphate) alpha-glucosyltransferase KEGG: lme:LEUM_0010 poly(glycerol-phosphate) alpha-glucosyltransferase gene gene1431 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01432 WSWS_01433 WSWS_01433 garR garR 1455497 1456366 - 2-hydroxy-3-oxopropionate reductase Belongs to the 3-hydroxyisobutyrate dehydrogenase family%3B KEGG: ecm:EcSMS35_4864 2-hydroxy-3-oxopropionate reductase gene gene1432 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01433 WSWS_01434 WSWS_01434 WSWS_01434 1456592 1457164 - Xanthine phosphoribosyltransferase Converts the preformed base xanthine%2C a product of nucleic acid breakdown%2C to xanthosine 5'-monophosphate (XMP)%2C so it can be reused for RNA or DNA synthesis%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily%3B KEGG: ban:BA_1591 xanthine phosphoribosyltransferase gene gene1433 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01434 WSWS_01435 WSWS_01435 WSWS_01435 1457186 1458475 - Uric acid permease PucK Uptake of uric acid%3B Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2. A. 40) subfamily gene gene1434 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01435 WSWS_01436 WSWS_01436 WSWS_01436 1459055 1460140 + CD4+ T-cell-stimulating antigen Belongs to the BMP lipoprotein family gene gene1435 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01436 WSWS_01437 WSWS_01437 WSWS_01437 1460376 1461680 + Guanine/hypoxanthine permease PbuG Involved in the uptake of the purine bases hypoxanthine and guanine%3B Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2. A. 1. 40) subfamily gene gene1436 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01437 WSWS_01438 WSWS_01438 pyrG pyrG 1461789 1463399 - CTP synthase (glutamine hydrolyzing) Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen%3B Belongs to the CTP synthase family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: rip:RIEPE_0212 CTP synthase gene gene1437 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01438 WSWS_01439 WSWS_01439 WSWS_01439 1463622 1464650 - putative tRNA-dihydrouridine synthase Catalyzes the synthesis of 5%2C6-dihydrouridine (D)%2C a modified base found in the D-loop of most tRNAs%2C via the reduction of the C5-C6 double bond in target uridines%3B Belongs to the Dus family gene gene1438 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01439 WSWS_01440 WSWS_01440 WSWS_01440 1464775 1466025 - hypothetical protein gene gene1439 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01440 WSWS_01441 WSWS_01441 yarS yarS 1466089 1467351 - Tyrosine--tRNA ligase Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)%3B Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily%3B Contains 1 S4 RNA-binding domain%3B KEGG: hde:HDEF_0671 tyrosyl-tRNA synthetase gene gene1440 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01441 WSWS_01442 WSWS_01442 WSWS_01442 1467688 1468596 - Phosphogluconate dehydrogenase (NADP(+)-dependent%2C decarboxylating) Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2)%2C with concomitant reduction of NADP to NADPH%3B Belongs to the 6-phosphogluconate dehydrogenase family%3B KEGG: lme:LEUM_0551 6-phosphogluconate dehydrogenase gene gene1441 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01442 WSWS_01443 WSWS_01443 WSWS_01443 1468772 1469614 + putative HTH-type transcriptional regulator Contains 1 HTH rpiR-type DNA-binding domain%3B Contains 1 SIS domain gene gene1442 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01443 WSWS_01444 WSWS_01444 WSWS_01444 1469684 1470355 - hypothetical protein gene gene1443 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01444 WSWS_01445 WSWS_01445 WSWS_01445 1470358 1470567 - hypothetical protein gene gene1444 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01445 WSWS_01446 WSWS_01446 metC metC 1470637 1471782 - Cystathionine beta-lyase Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine%2C via a gamma- replacement reaction. In the absence of thiol%2C catalyzes gamma- elimination to form 2-oxobutanoate%2C succinate and ammonia%3B Belongs to the trans-sulfuration enzymes family%3B KEGG: ooe:OEOE_0766 cystathionine beta-lyase gene gene1445 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01446 WSWS_01447 WSWS_01447 WSWS_01447 1472301 1473200 + putative lipoprotein YhcJ Belongs to the NlpA lipoprotein family gene gene1446 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01447 WSWS_01448 WSWS_01448 luxS luxS 1473212 1473691 + S-ribosylhomocysteine lyase Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4%2C5- dihydroxy-2%2C3-pentadione (DPD)%3B Belongs to the LuxS family%3B KEGG: thl:TEH_00900 S-ribosylhomocysteine lyase gene gene1447 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01448 WSWS_01449 WSWS_01449 metE metE 1473708 1474820 + 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase To B. subtilis YxjH%3B KEGG: llm:llmg_1849 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase gene gene1448 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01449 WSWS_01450 WSWS_01450 WSWS_01450 1474926 1475918 - hypothetical protein gene gene1449 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01450 WSWS_01451 WSWS_01451 WSWS_01451 1476163 1477311 - Hippurate hydrolase Belongs to the peptidase M20 family%3B KEGG: rme:Rmet_0021 hippurate hydrolase gene gene1450 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01451 WSWS_01452 WSWS_01452 WSWS_01452 1477313 1477630 - Thioredoxin Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Belongs to the thioredoxin family%3B Contains 1 thioredoxin domain gene gene1451 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01452 WSWS_01453 WSWS_01453 WSWS_01453 1477749 1477821 - tRNA-Asn tRNA gene1452 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01453 WSWS_01454 WSWS_01454 WSWS_01454 1477954 1478088 - hypothetical protein gene gene1453 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01454 WSWS_01455 WSWS_01455 WSWS_01455 1478227 1478299 - tRNA-Thr tRNA gene1454 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01455 WSWS_01456 WSWS_01456 WSWS_01456 1478306 1478378 - tRNA-Asn tRNA gene1455 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01456 WSWS_01457 WSWS_01457 WSWS_01457 1478384 1478500 - 5S ribosomal RNA rRNA gene1456 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01457 WSWS_01458 WSWS_01458 WSWS_01458 1478594 1481510 - 23S ribosomal RNA rRNA gene1457 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01458 WSWS_01459 WSWS_01459 WSWS_01459 1481723 1481795 - tRNA-Ala tRNA gene1458 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01459 WSWS_01460 WSWS_01460 WSWS_01460 1481876 1483452 - 16S ribosomal RNA rRNA gene1459 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01460 WSWS_01461 WSWS_01461 karS karS 1483930 1485414 - Lysine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: wko:WKK_04170 lysyl-tRNA synthetase%2C class II gene gene1460 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01461 WSWS_01462 WSWS_01462 WSWS_01462 1485470 1486387 - 33 kDa chaperonin Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress%3B Belongs to the HSP33 family gene gene1461 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01462 WSWS_01463 WSWS_01463 alsD alsD 1486526 1487242 - Acetolactate decarboxylase Converts acetolactate into acetoin%3B Belongs to the alpha-acetolactate decarboxylase family%3B KEGG: lre:Lreu_0133 acetolactate decarboxylase gene gene1462 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01463 WSWS_01464 WSWS_01464 ilvB ilvB 1487309 1488994 - Acetolactate synthase Belongs to the TPP enzyme family%3B KEGG: lme:LEUM_0522 acetolactate synthase I/II/III large subunit gene gene1463 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01464 WSWS_01465 WSWS_01465 ftsH ftsH 1489155 1491230 - ATP-dependent zinc metalloprotease FtsH Acts as a processive%2C ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins%3B In the central sectio%3B belongs to the AAA ATPase family%3B In the C-terminal sectio%3B belongs to the peptidase M41 family%3B KEGG: wko:WKK_04135 cell division protease FtsH%3B Metalloendopeptidases gene gene1464 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01465 WSWS_01466 WSWS_01466 WSWS_01466 1491399 1491986 - Hypoxanthine phosphoribosyltransferase Essential in nucleic acid metabolism of T. foetus because the parasite is unable to synthesize purine nucleotides de novo and relies on the HGXPRTase activities for its purine requirements by salvaging purine bases from the host. Works with guanine%2C hypoxanthine and xanthine. Belongs to the purine/pyrimidine phosphoribosyltransferase family%3B KEGG: wce:WS08_0244 hypoxanthine phosphoribosyltransferase gene gene1465 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01466 WSWS_01467 WSWS_01467 tilS tilS 1492057 1493031 - tRNA(Ile)-lysidine synthetase Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU%2C in an ATP-dependent manner. Cytidine is converted to lysidine%2C thus changing the amino acid specificity of the tRNA from methionine to isoleucine%3B Belongs to the tRNA(Ile)-lysidine synthase family%3B KEGG: wko:WKK_04125 tRNA(Ile)-lysidine synthase gene gene1466 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01467 WSWS_01468 WSWS_01468 WSWS_01468 1493135 1493506 - hypothetical protein gene gene1467 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01468 WSWS_01469 WSWS_01469 WSWS_01469 1493684 1493962 - uncharacterized protein Contains 1 S4 RNA-binding domain gene gene1468 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01469 WSWS_01470 WSWS_01470 WSWS_01470 1493962 1495539 - putative membrane protein YabM Belongs to the polysaccharide synthase family gene gene1469 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01470 WSWS_01471 WSWS_01471 WSWS_01471 1495523 1499050 - Transcription-repair-coupling factor Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA%2C and recruitment of nucleotide excision repair machinery to the damaged site%3B In the N-terminal sectio%3B belongs to the UvrB family%3B In the C-terminal sectio%3B belongs to the helicase family. RecG subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: lsl:LSL_1360 transcription-repair coupling factor (superfamily II helicase)%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene1470 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01471 WSWS_01472 WSWS_01472 pth1 pth1 1499061 1499627 - Aminoacyl-tRNA hydrolase The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis%3B Belongs to the PTH family%3B KEGG: bcc:BCc_123 peptidyl-tRNA hydrolase%2C PTH1 family gene gene1471 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01472 WSWS_01473 WSWS_01473 WSWS_01473 1499807 1500652 + hypothetical protein gene gene1472 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01473 WSWS_01474 WSWS_01474 WSWS_01474 1500699 1501346 - hypothetical protein gene gene1473 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01474 WSWS_01475 WSWS_01475 WSWS_01475 1501610 1503121 - Xylulokinase Belongs to the FGGY kinase family%3B KEGG: sep:SE2085 xylulokinase gene gene1474 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01475 WSWS_01476 WSWS_01476 xylA xylA 1503432 1504862 - Xylose isomerase Belongs to the xylose isomerase family%3B KEGG: wko:WKK_04485 xylose isomerase gene gene1475 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01476 WSWS_01477 WSWS_01477 WSWS_01477 1505180 1505503 - HTH-type transcriptional repressor CzrA Metal-responsive transcriptional regulator that represses transcription of cadA and the czcD-trkA operon by binding specifically to their promoter. Binding of zinc causes the repressor to dissociate from the DNA%3B Contains 1 HTH arsR-type DNA-binding domain gene gene1476 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01477 WSWS_01478 WSWS_01478 WSWS_01478 1505513 1506121 - hypothetical protein gene gene1477 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01478 WSWS_01479 WSWS_01479 WSWS_01479 1506236 1507111 - Putative ribonuclease-like protein YfkH gene gene1478 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01479 WSWS_01480 WSWS_01480 WSWS_01480 1507492 1507740 - hypothetical protein gene gene1479 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01480 WSWS_01481 WSWS_01481 WSWS_01481 1507778 1508059 - hypothetical protein gene gene1480 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01481 WSWS_01482 WSWS_01482 WSWS_01482 1508074 1509504 - putative symporter YjmB Belongs to the sodium:galactoside symporter (TC 2. A. 2) family gene gene1481 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01482 WSWS_01483 WSWS_01483 WSWS_01483 1509899 1511107 + Glucokinase Transcriptional repressor of xylose-utilizing enzymes. Belongs to the ROK (NagC/XylR) family%3B KEGG: pto:PTO1216 glucokinase gene gene1482 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01483 WSWS_01484 WSWS_01484 WSWS_01484 1511154 1511564 - hypothetical protein gene gene1483 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01484 WSWS_01485 WSWS_01485 bacA bacA 1511690 1512541 - Undecaprenyl-diphosphate phosphatase Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin%3B Belongs to the UppP family%3B KEGG: buc:BU062 undecaprenyl-diphosphatase gene gene1484 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01485 WSWS_01486 WSWS_01486 WSWS_01486 1512605 1513603 - hypothetical protein gene gene1485 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01486 WSWS_01487 WSWS_01487 WSWS_01487 1513587 1514228 - hypothetical protein gene gene1486 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01487 WSWS_01488 WSWS_01488 WSWS_01488 1514218 1514535 - hypothetical protein gene gene1487 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01488 WSWS_01489 WSWS_01489 WSWS_01489 1514633 1514896 + hypothetical protein gene gene1488 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01489 WSWS_01490 WSWS_01490 WSWS_01490 1515067 1515894 - putative ABC transporter permease protein YurM Probably part of the binding-protein-dependent transport system YurMNO. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1489 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01490 WSWS_01491 WSWS_01491 WSWS_01491 1515894 1516802 - sn-glycerol-3-phosphate transport system permease protein UgpA Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family%3B Contains 1 ABC transmembrane type-1 domain gene gene1490 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01491 WSWS_01492 WSWS_01492 WSWS_01492 1516799 1517851 - Carnitine transport ATP-binding protein OpuCA Part of the ABC transporter complex OpuCABCD involved in carnitine uptake. Probably responsible for energy coupling to the transport system. Involved%2C with BetL and GbuABC%2C in osmoprotection and cryoprotection of Listeria. Can also mediate weak glycine betaine transport%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B Contains 2 CBS domains gene gene1491 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01492 WSWS_01493 WSWS_01493 cpdB cpdB 1517866 1519446 - 2'%2C3'-cyclic-nucleotide 2'-phosphodiesterase KEGG: wko:WKK_02265 2'%2C3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase gene gene1492 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01493 WSWS_01494 WSWS_01494 WSWS_01494 1519771 1521066 - Putative transcriptional regulator YvhJ Belongs to the LytR/CpsA/Psr regulatory protein family gene gene1493 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01494 WSWS_01495 WSWS_01495 thyA thyA 1521322 1522278 - Thymidylate synthase Provides the sole de novo source of dTMP for DNA biosynthesis%3B Belongs to the thymidylate synthase family. Bacterial- type ThyA subfamily%3B KEGG: axl:AXY_12820 thymidylate synthase gene gene1494 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01495 WSWS_01496 WSWS_01496 WSWS_01496 1522291 1522770 - dCMP deaminase Dispensable for transformability. Belongs to the cytidine and deoxycytidylate deaminase family%3B Contains 1 CMP/dCMP-type deaminase domain%3B KEGG: dvu:DVU1202 dCMP deaminase gene gene1495 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01496 WSWS_01497 WSWS_01497 WSWS_01497 1523071 1523304 + Protein Veg Stimulates biofilm formation via transcriptional activation of extracellular matrix genes. Acts by repressing SinR activity%2C independently of the SinI%2C SlrA and SlrR pathways. Could also be involved in the regulation of other genes during biofilm and spore formation gene gene1496 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01497 WSWS_01498 WSWS_01498 WSWS_01498 1523404 1524765 - UPF0053 protein YhdT Belongs to the UPF0053 family%3B Contains 2 CBS domains%3B Contains 1 DUF21 domain gene gene1497 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01498 WSWS_01499 WSWS_01499 WSWS_01499 1524880 1526247 - UPF0053 protein Belongs to the UPF0053 family%3B Contains 2 CBS domains%3B Contains 1 DUF21 domain gene gene1498 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01499 WSWS_01500 WSWS_01500 ksgA ksgA 1526350 1527246 - 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily%3B KEGG: lbh:Lbuc_1601 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase gene gene1499 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01500 WSWS_01501 WSWS_01501 rnmV rnmV 1527247 1527795 - Ribonuclease M5 Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step%3B Belongs to the ribonuclease M5 family%3B Contains 1 Toprim domain%3B KEGG: bsu:BSU00410 ribonuclease M5 gene gene1500 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01501 WSWS_01502 WSWS_01502 tatD tatD 1527848 1528651 - Putative deoxyribonuclease TATDN1 Putative deoxyribonuclease%3B Belongs to the TatD-type hydrolase family%3B KEGG: ooe:OEOE_1551 TatD DNase family protein%3B Endodeoxyribonucleases producing 5'-phosphomonoesters gene gene1501 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01502 WSWS_01503 WSWS_01503 WSWS_01503 1528933 1529934 + UPF0324 membrane protein Belongs to the UPF0324 family gene gene1502 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01503 WSWS_01504 WSWS_01504 dusB dusB 1530180 1531214 + putative tRNA-dihydrouridine synthase Catalyzes the synthesis of 5%2C6-dihydrouridine (D)%2C a modified base found in the D-loop of most tRNAs%2C via the reduction of the C5-C6 double bond in target uridines%3B Belongs to the Dus family%3B KEGG: toc:Toce_2083 tRNA-dihydrouridine synthase B%3B Oxidoreductases gene gene1503 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01504 WSWS_01505 WSWS_01505 WSWS_01505 1531226 1531807 + DNA-3-methyladenine glycosylase I KEGG: lki:LKI_06820 DNA-3-methyladenine glycosylase I gene gene1504 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01505 WSWS_01506 WSWS_01506 WSWS_01506 1532002 1532889 + Acetyl esterase Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin)%2C but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity%3B Belongs to the 'GDXG' lipolytic enzyme family%3B KEGG: eco:b0476 acetyl esterase%3B Carboxylic ester hydrolases gene gene1505 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01506 WSWS_01507 WSWS_01507 WSWS_01507 1532988 1534325 - putative transporter YdgF Probable amino-acid or metabolite transport protein. Belongs to the amino acid-polyamine-organocation (APC) superfamily gene gene1506 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01507 WSWS_01508 WSWS_01508 gshA gshA 1534443 1535912 + Glutamate--cysteine ligase Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily%3B KEGG: lmu:LBLM1_05275 glutamate--cysteine ligase gene gene1507 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01508 WSWS_01509 WSWS_01509 WSWS_01509 1535987 1536394 + hypothetical protein gene gene1508 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01509 WSWS_01510 WSWS_01510 WSWS_01510 1536512 1537510 + hypothetical protein gene gene1509 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01510 WSWS_01511 WSWS_01511 galT galT 1537614 1539071 - UDP-glucose--hexose-1-phosphate uridylyltransferase Belongs to the galactose-1-phosphate uridylyltransferase type 2 family%3B KEGG: pce:PECL_1659 UDPglucose--hexose-1-phosphate uridylyltransferase gene gene1510 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01511 WSWS_01512 WSWS_01512 galK galK 1539099 1540274 - Galactokinase Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)%3B Belongs to the GHMP kinase family. GalK subfamily%3B KEGG: phe:Phep_2134 galactokinase gene gene1511 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01512 WSWS_01513 WSWS_01513 WSWS_01513 1540447 1541475 - HTH-type transcriptional regulator EbgR Repressor for beta galactosidase alpha and beta subunits (ebgA and ebgC). Binds lactose as an inducer. Contains 1 HTH lacI-type DNA-binding domain gene gene1512 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01513 WSWS_01514 WSWS_01514 WSWS_01514 1541708 1543615 + Lactose permease In the N-terminal sectio%3B belongs to the sodium:galactoside symporter (TC 2. A. 2) family%3B Contains 1 PTS EIIA type-1 domain gene gene1513 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01514 WSWS_01515 WSWS_01515 ebgA ebgA 1543702 1546749 + Beta-galactosidase The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme. Belongs to the glycosyl hydrolase 2 family%3B KEGG: eco:b3076 evolved beta-galactosidase subunit alpha gene gene1514 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01515 WSWS_01516 WSWS_01516 WSWS_01516 1546835 1548019 - putative aspartate aminotransferase Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: pce:PECL_146 aminotransferase%3B Transaminases gene gene1515 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01516 WSWS_01517 WSWS_01517 WSWS_01517 1548038 1548865 - putative D-methionine-binding lipoprotein MetQ This protein is a component of a D-methionine permease%2C a binding protein-dependent%2C ATP-driven transport system%3B Belongs to the NlpA lipoprotein family gene gene1516 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01517 WSWS_01518 WSWS_01518 licD licD 1549245 1550087 - Lipopolysaccharide cholinephosphotransferase LicD Transfers phosphorylcholine (ChoP) from choline diphosphonucleoside to the lipopolysaccharide (LPS)%3B Belongs to the LicD transferase family%3B KEGG: efa:EF2168 lipopolysaccharide cholinephosphotransferase%3B Transferases for other substituted phosphate groups gene gene1517 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01518 WSWS_01519 WSWS_01519 WSWS_01519 1550188 1551087 - UTP--glucose-1-phosphate uridylyltransferase Catalyzes the formation of UDP-glucose from glucose-1- phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG) (By similarity)%3B Belongs to the UDPGP type 2 family%3B KEGG: rpm:RSPPHO_00814 UTP--glucose-1-phosphate uridylyltransferase gene gene1518 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01519 WSWS_01520 WSWS_01520 WSWS_01520 1551109 1552377 - hypothetical protein gene gene1519 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01520 WSWS_01521 WSWS_01521 WSWS_01521 1552374 1553159 - Putative acetyltransferase Belongs to the transferase hexapeptide repeat family%3B KEGG: asu:Asuc_0071 null%3B Transferring groups other than amino-acyl groups gene gene1520 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01521 WSWS_01522 WSWS_01522 WSWS_01522 1553159 1554787 - hypothetical protein gene gene1521 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01522 WSWS_01523 WSWS_01523 waaV waaV 1554870 1560185 - Putative glycosyltransferase EpsH May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles. Required for biofilm maintenance%3B Belongs to the glycosyltransferase 2 family%3B KEGG: ecc:c4449 UDP-glucose:(glucosyl)LPS beta-1%2C3-glucosyltransferase%3B Hexosyltransferases gene gene1522 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01523 WSWS_01524 WSWS_01524 WSWS_01524 1560275 1561003 - hypothetical protein gene gene1523 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01524 WSWS_01525 WSWS_01525 WSWS_01525 1561035 1561793 - hypothetical protein gene gene1524 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01525 WSWS_01526 WSWS_01526 WSWS_01526 1561812 1562201 - hypothetical protein gene gene1525 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01526 WSWS_01527 WSWS_01527 WSWS_01527 1562215 1563036 - Teichoic acid translocation permease protein TagG Part of the ABC transporter complex TagGH (TC 3. A. 1. 34. 1) involved in exporting the two types of intracellularly synthesized teichoic acids. Probably responsible for the translocation of the substrate across the membrane. Belongs to the ABC-2 integral membrane protein family%3B Contains 1 ABC transmembrane type-2 domain gene gene1526 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01527 WSWS_01528 WSWS_01528 WSWS_01528 1563042 1564337 - Teichoic-acid-transporting ATPase Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Teichoic acids exporter (TC 3. A. 1. 104. 1) family%3B Contains 1 ABC transporter domain%3B KEGG: lcn:C270_02945 teichoic acid transport system ATP-binding protein gene gene1527 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01528 WSWS_01529 WSWS_01529 WSWS_01529 1564341 1565156 - Serine-rich adhesin for platelets Mediates binding to human platelets%2C possibly through a receptor-ligand interaction%3B Belongs to the SraP family gene gene1528 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01529 WSWS_01530 WSWS_01530 WSWS_01530 1565316 1567040 - hypothetical protein gene gene1529 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01530 WSWS_01531 WSWS_01531 WSWS_01531 1567074 1571153 - CDP-glycerol glycerophosphotransferase Catalyzes the addition of a single ribitol-P residue onto the second glycerol-P of the linkage unit%2C as a primer for polymerisation by TarL%3B Belongs to the CDP-glycerol glycerophosphotransferase family%3B KEGG: ecas:ECBG_01911 CDP-glycerol glycerophosphotransferase gene gene1530 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01531 WSWS_01532 WSWS_01532 WSWS_01532 1571212 1572369 - CDP-glycerol glycerophosphotransferase Catalyzes the addition of a single glycerol-P residue to the prenolpyrophosphate-linked disaccharide%2C as a primer for polymerisation by TagF%3B Belongs to the CDP-glycerol glycerophosphotransferase family%3B KEGG: wce:WS08_0779 CDP-glycerol glycerophosphotransferase gene gene1531 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01532 WSWS_01533 WSWS_01533 tagD tagD 1572398 1572832 - Glycerol-3-phosphate cytidylyltransferase Provides activated glycerol phosphate for teichoic acid synthesis%2C via incorporation into both the linkage unit and the teichoic acid polymer by TagB and TagF. Belongs to the cytidylyltransferase family%3B KEGG: ecc:c3696 glycerol-3-phosphate cytidylyltransferase gene gene1532 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01533 WSWS_01534 WSWS_01534 vanY vanY 1573014 1573796 - Serine-type D-Ala-D-Ala carboxypeptidase Vancomycin-inducible%2C penicillin-resistant%2C DD- carboxypeptidase that hydrolyzes depsipeptide- and D-alanyl-D- alanine-containing peptidoglycan precursors. Insensitive to beta- lactams. Belongs to the peptidase M15B family%3B KEGG: wko:WKK_00495 D-alanyl-D-alanine carboxypeptidase gene gene1533 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01534 WSWS_01535 WSWS_01535 WSWS_01535 1573970 1574086 - 5S ribosomal RNA rRNA gene1534 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01535 WSWS_01536 WSWS_01536 WSWS_01536 1574180 1577096 - 23S ribosomal RNA rRNA gene1535 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01536 WSWS_01537 WSWS_01537 WSWS_01537 1577308 1577381 - tRNA-Ile tRNA gene1536 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01537 WSWS_01538 WSWS_01538 WSWS_01538 1577474 1579050 - 16S ribosomal RNA rRNA gene1537 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01538 WSWS_01539 WSWS_01539 npdA npdA 1579449 1580147 - NAD-dependent protein deacetylase NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form%3B Belongs to the sirtuin family. Class U subfamily%3B Contains 1 deacetylase sirtuin-type domain%3B KEGG: lac:LBA0117 NAD-dependent deacetylase%3B In linear amides gene gene1538 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01539 WSWS_01540 WSWS_01540 WSWS_01540 1580165 1581124 - hypothetical protein gene gene1539 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01540 WSWS_01541 WSWS_01541 mvaA mvaA 1581121 1582377 - Hydroxymethylglutaryl-CoA reductase Converts HMG-CoA to mevalonate%3B Belongs to the HMG-CoA reductase family%3B KEGG: lsn:LSA_03920 hydroxymethylglutaryl-CoA reductase gene gene1540 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01541 WSWS_01542 WSWS_01542 WSWS_01542 1582377 1582820 - hypothetical protein gene gene1541 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01542 WSWS_01543 WSWS_01543 WSWS_01543 1582970 1585156 - Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate%2C a reaction that presumably uses phosphatidylglycerol (PG) as substrate%3B Belongs to the LTA synthase family%3B KEGG: wko:WKK_03885 lipoteichoic acid synthase gene gene1542 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01543 WSWS_01544 WSWS_01544 WSWS_01544 1585370 1585816 + Putative acetyltransferase Could catalyze the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and release both CoA and the acetylated product%3B Belongs to the UPF0039 (ElaA) family%3B Contains 1 N-acetyltransferase domain%3B KEGG: vfi:VF_A0626 null%3B Transferring groups other than amino-acyl groups gene gene1543 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01544 WSWS_01545 WSWS_01545 WSWS_01545 1585931 1586143 - hypothetical protein gene gene1544 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01545 WSWS_01546 WSWS_01546 WSWS_01546 1586368 1588944 - DNA topoisomerase (ATP-hydrolyzing) DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings%2C including catenanes and knotted rings%3B Belongs to the topoisomerase GyrA/ParC subunit family%3B KEGG: pih:UB51_22110 DNA gyrase subunit A gene gene1545 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01546 WSWS_01547 WSWS_01547 WSWS_01547 1589007 1590953 - DNA topoisomerase (ATP-hydrolyzing) DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings%2C including catenanes and knotted rings%3B Belongs to the type II topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: lmo:lmo0006 DNA gyrase subunit B gene gene1546 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01547 WSWS_01548 WSWS_01548 WSWS_01548 1590956 1592080 - DNA replication and repair protein RecF The RecF protein is involved in DNA metabolis%3B it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded%2C linear DNA. It also seems to bind ATP%3B Belongs to the RecF family gene gene1547 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01548 WSWS_01549 WSWS_01549 WSWS_01549 1592080 1592310 - uncharacterized protein Contains 1 S4 RNA-binding domain gene gene1548 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01549 WSWS_01550 WSWS_01550 phoA phoA 1592583 1593206 + Alkaline phosphatase Belongs to the DedA family%3B KEGG: bcl:ABC0731 alkaline phosphatase gene gene1549 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01550 WSWS_01551 WSWS_01551 WSWS_01551 1593294 1593584 - hypothetical protein gene gene1550 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01551 WSWS_01552 WSWS_01552 dnaN dnaN 1593604 1594734 - DNA-directed DNA polymerase DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA%2C it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)%3B KEGG: llc:LACR_0002 DNA polymerase III subunit beta gene gene1551 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01552 WSWS_01553 WSWS_01553 WSWS_01553 1594934 1596346 - Chromosomal replication initiator protein DnaA Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replicatio%3B it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids%3B Belongs to the DnaA family gene gene1552 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01553 WSWS_01554 WSWS_01554 WSWS_01554 1597010 1597144 + 50S ribosomal protein L34 Belongs to the ribosomal protein L34P family gene gene1553 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01554 WSWS_01555 WSWS_01555 rnpA rnpA 1597266 1597607 + Ribonuclease P RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4. 5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme%3B Belongs to the RnpA family%3B KEGG: bck:BCO26_2974 ribonuclease P protein component gene gene1554 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01555 WSWS_01556 WSWS_01556 WSWS_01556 1597687 1598532 + Membrane protein insertase YidC Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex%2C as well as at least some lipoproteins%3B Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily gene gene1555 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01556 WSWS_01557 WSWS_01557 WSWS_01557 1598670 1600388 + hypothetical protein gene gene1556 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01557 WSWS_01558 WSWS_01558 WSWS_01558 1600527 1601459 - hypothetical protein gene gene1557 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01558 WSWS_01559 WSWS_01559 WSWS_01559 1601590 1602123 - hypothetical protein gene gene1558 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01559 WSWS_01560 WSWS_01560 WSWS_01560 1602137 1602448 - hypothetical protein gene gene1559 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01560 WSWS_01561 WSWS_01561 WSWS_01561 1602474 1602914 - hypothetical protein gene gene1560 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01561 WSWS_01562 WSWS_01562 WSWS_01562 1602977 1603705 - Putative transposase InsK for insertion sequence element IS150 Involved in the transposition of the insertion sequence IS150. Belongs to the transposase IS3/IS150/IS904 family%3B Contains 1 integrase catalytic domain gene gene1561 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01562 WSWS_01563 WSWS_01563 WSWS_01563 1603828 1603983 - hypothetical protein gene gene1562 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01563 WSWS_01564 WSWS_01564 WSWS_01564 1604002 1604334 - hypothetical protein gene gene1563 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01564 WSWS_01565 WSWS_01565 WSWS_01565 1604428 1605657 + hypothetical protein gene gene1564 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01565 WSWS_01566 WSWS_01566 WSWS_01566 1605974 1606744 + hypothetical protein gene gene1565 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01566 WSWS_01567 WSWS_01567 WSWS_01567 1606769 1607857 + hypothetical protein gene gene1566 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01567 WSWS_01568 WSWS_01568 WSWS_01568 1607910 1608374 - hypothetical protein gene gene1567 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01568 WSWS_01569 WSWS_01569 menA menA 1608384 1609280 - 1%2C4-dihydroxy-2-naphthoate octaprenyltransferase Conversion of 1%2C4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK)%3B Belongs to the MenA family. Type 1 subfamily%3B KEGG: wce:WS08_1240 1%2C4-dihydroxy-2-naphthoate octaprenyltransferase%3B 1%2C4-dihydroxy-2-naphthoate polyprenyltransferase gene gene1568 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01569 WSWS_01570 WSWS_01570 acyP acyP 1609296 1609568 - Acylphosphatase Belongs to the acylphosphatase family%3B Contains 1 acylphosphatase-like domain%3B KEGG: cni:Calni_0286 acylphosphatase gene gene1569 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01570 WSWS_01571 WSWS_01571 WSWS_01571 1609662 1610465 - L-cystine-binding protein FliY Part of the ABC transporter complex FliY-YecC-YecS involved in L-cystine transport. Binds cystine%3B Belongs to the bacterial solute-binding protein 3 family gene gene1570 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01571 WSWS_01572 WSWS_01572 WSWS_01572 1610876 1611571 + putative amino-acid ABC transporter permease protein PatM Probably part of a binding-protein-dependent transport system for an amino acid. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1571 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01572 WSWS_01573 WSWS_01573 WSWS_01573 1611582 1612316 + Histidine transport ATP-binding protein Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B KEGG: plu:plu4486 cystine transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene1572 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01573 WSWS_01574 WSWS_01574 WSWS_01574 1612491 1614506 + Leucine--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: pae:PA3987 leucyl-tRNA synthetase gene gene1573 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01574 WSWS_01575 WSWS_01575 lepB lepB 1614671 1615291 + Signal peptidase I Essential for cell viability%3B Belongs to the peptidase S26 family%3B KEGG: lpl:lp_2862 signal peptidase I gene gene1574 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01575 WSWS_01576 WSWS_01576 WSWS_01576 1615453 1616118 + Ktr system potassium uptake protein Catalytic subunit of the KtrAB potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress%3B Belongs to the KtrA potassium transport family%3B Contains 1 RCK C-terminal domain%3B Contains 1 RCK N-terminal domain gene gene1575 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01576 WSWS_01577 WSWS_01577 rlmH rlmH 1616169 1616651 - 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA%3B Belongs to the RNA methyltransferase RlmH family%3B KEGG: lru:HMPREF0538_21181 23S rRNA (pseudouridine1915-N3)-methyltransferase gene gene1576 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01577 WSWS_01578 WSWS_01578 WSWS_01578 1617340 1618680 + Ktr system potassium uptake protein Integral membrane subunit of the KtrCD potassium uptake transporter. The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress%3B Belongs to the TrkH potassium transport family. Ktr (TC 2. A. 38. 4) subfamily gene gene1577 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01578 WSWS_01579 WSWS_01579 WSWS_01579 1618696 1619514 + Sugar phosphatase YbiV Catalyzes the hydrolysis of sugar phosphate to sugar and inorganic phosphate. Has a wide substrate specificity catalyzing the hydrolysis of ribose-5-phosphate%2C glucose-6-phosphate%2C fructose-1-phosphate%2C acetyl-phosphate%2C glycerol-1-phosphate%2C glycerol-2-phosphate%2C 2-deoxy-glucose-6-phosphate%2C mannose-6- phosphate and fructose-6-phosphate. Appears to have a low level of phosphotransferase activity using monophosphates as the phosphate donor%3B Belongs to the HAD-like hydrolase superfamily. Cof family. SupH subfamily gene gene1578 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01579 WSWS_01580 WSWS_01580 WSWS_01580 1619643 1620203 + hypothetical protein gene gene1579 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01580 WSWS_01581 WSWS_01581 WSWS_01581 1620509 1621696 + Arginine--pyruvate transaminase AruH Catalyzes the conversion of L-arginine into 2- ketoarginine via transamination. L-arginine is the best substrate%2C but it can also use L-lysine%2C L-methionine%2C L-leucine%2C ornithine and L-glutamine%2C which indicates that it may have a broader physiological function in amino acid catabolism%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: ooe:OEOE_0777 aminotransferase%3B Transaminases gene gene1580 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01581 WSWS_01582 WSWS_01582 WSWS_01582 1621686 1622681 + D-lactate dehydrogenase Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B KEGG: lsl:LSL_0308 D-lactate dehydrogenase gene gene1581 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01582 WSWS_01583 WSWS_01583 WSWS_01583 1622694 1623728 + hypothetical protein gene gene1582 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01583 WSWS_01584 WSWS_01584 WSWS_01584 1623786 1624244 - hypothetical protein gene gene1583 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01584 WSWS_01585 WSWS_01585 WSWS_01585 1624491 1625957 + D-xylose-proton symporter Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system)%3B Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family gene gene1584 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01585 WSWS_01586 WSWS_01586 WSWS_01586 1626315 1627010 + Ribonuclease H Endonuclease that specifically degrades the RNA of RNA- DNA hybrids%3B Belongs to the RNase H family%3B Contains 1 RNase H domain%3B KEGG: wko:WKK_03525 ribonuclease HI gene gene1585 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01586 WSWS_01587 WSWS_01587 WSWS_01587 1627049 1627492 - Homoprotocatechuate degradative operon repressor Repressor for the homoprotocatechuate catabolic pathway hpc operon. Contains 1 HTH marR-type DNA-binding domain gene gene1586 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01587 WSWS_01588 WSWS_01588 WSWS_01588 1627613 1628566 + NADPH:quinone reductase KEGG: lsa:LSA1875 NADPH2:quinone reductase gene gene1587 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01588 WSWS_01589 WSWS_01589 WSWS_01589 1628692 1629369 + hypothetical protein gene gene1588 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01589 WSWS_01590 WSWS_01590 WSWS_01590 1629632 1630153 - hypothetical protein gene gene1589 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01590 WSWS_01591 WSWS_01591 WSWS_01591 1631254 1631682 + hypothetical protein gene gene1590 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01591 WSWS_01592 WSWS_01592 WSWS_01592 1631858 1633054 + hypothetical protein gene gene1591 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01592 WSWS_01593 WSWS_01593 WSWS_01593 1633107 1635545 - uncharacterized protein To L. lactis phage infection protein (PIP) gene gene1592 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01593 WSWS_01594 WSWS_01594 WSWS_01594 1635660 1636241 + hypothetical protein gene gene1593 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01594 WSWS_01595 WSWS_01595 glcD glcD 1636500 1637873 + (S)-2-hydroxy-acid oxidase In addition to its enzymatic role it could play an important role in the yeast cell morphology%3B Belongs to the FAD-binding oxidoreductase/transferase type 4 family%3B Contains 1 FAD-binding PCMH-type domain%3B KEGG: bha:BH2134 glycolate oxidase gene gene1594 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01595 WSWS_01596 WSWS_01596 WSWS_01596 1637984 1638688 + putative membrane protein Belongs to the AzlC family gene gene1595 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01596 WSWS_01597 WSWS_01597 WSWS_01597 1638701 1639021 + hypothetical protein gene gene1596 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01597 WSWS_01598 WSWS_01598 WSWS_01598 1639109 1640245 + Succinyl-diaminopimelate desuccinylase Catalyzes the hydrolysis of N-succinyl-L%2CL- diaminopimelic acid (SDAP)%2C forming succinate and LL-2%2C6- diaminoheptanedioate (DAP)%2C an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid%2C an essential component of bacterial cell walls%3B Belongs to the peptidase M20A family. DapE subfamily%3B KEGG: lpr:LBP_cg2301 succinyl-diaminopimelate desuccinylase gene gene1597 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01598 WSWS_01599 WSWS_01599 WSWS_01599 1640621 1641853 + Serine/threonine transporter SstT Involved in the import of serine and threonine into the cell%2C with the concomitant import of sodium (symport system)%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene1598 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01599 WSWS_01600 WSWS_01600 WSWS_01600 1641967 1642926 + putative deferrochelatase/peroxidase YfeX Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact%3B Belongs to the DyP-type peroxidase family gene gene1599 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01600 WSWS_01601 WSWS_01601 guaA guaA 1643077 1644621 - GMP synthase (glutamine-hydrolyzing) Catalyzes the synthesis of GMP from XMP%3B Contains 1 glutamine amidotransferase type-1 domain%3B Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain%3B KEGG: tcu:Tcur_4247 GMP synthase (glutamine-hydrolysing) gene gene1600 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01601 WSWS_01602 WSWS_01602 WSWS_01602 1645144 1646382 - Raffinose permease Responsible for transport of raffinose into the cell%2C with the concomitant import of a proton (symport system). Belongs to the LacY/RafB permease family gene gene1601 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01602 WSWS_01603 WSWS_01603 WSWS_01603 1646404 1647384 - Extracellular exo-alpha-(1->5)-L-arabinofuranosidase Involved in the degradation of arabinan and is a key enzyme in the complete degradation of the plant cell wall. Catalyzes only the cleavage of terminal alpha-(1->5) arabinofuranosyl bonds of arabinan present in the arabinofuranosyl polysaccharides or oligosaccharides. It cannot act on other arabinose-containing polysaccharides and arabinoxylo- oligosaccharides%3B Belongs to the glycosyl hydrolase 43 family gene gene1602 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01603 WSWS_01604 WSWS_01604 WSWS_01604 1647594 1648484 + hypothetical protein gene gene1603 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01604 WSWS_01605 WSWS_01605 WSWS_01605 1648606 1649145 + hypothetical protein gene gene1604 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01605 WSWS_01606 WSWS_01606 trmA trmA 1649242 1650702 - tRNA (uracil(54)-C(5))-methyltransferase Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family%3B Contains 1 TRAM domain%3B KEGG: sph:MGAS10270_Spy1435 tRNA (uracil-5-)-methyltransferase gene gene1605 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01606 WSWS_01607 WSWS_01607 WSWS_01607 1651092 1652723 + Dipeptide-binding protein DppE Part of the binding-protein-dependent transport system for dipeptide%3B probably responsible for the binding of dipeptides with high affinity. Is expressed to facilitate adaptation to nutrient deficiency conditions%2C which also induce sporulation. Belongs to the bacterial solute-binding protein 5 family gene gene1606 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01607 WSWS_01608 WSWS_01608 gcy1 gcy1 1652829 1653692 - Glycerol 2-dehydrogenase (NADP(+)) Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis%3B Belongs to the aldo/keto reductase family%3B KEGG: cal:CaO19. 6757 glycerol 2-dehydrogenase (NADP+) gene gene1607 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01608 WSWS_01609 WSWS_01609 WSWS_01609 1653894 1654481 + hypothetical protein gene gene1608 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01609 WSWS_01610 WSWS_01610 WSWS_01610 1654561 1656111 - Lysozyme KEGG: lsa:LSA1788 lysozyme gene gene1609 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01610 WSWS_01611 WSWS_01611 WSWS_01611 1656225 1657151 - Phosphoglycerate dehydrogenase Catalyzes the NADPH-dependent reduction of 2%2C5-diketo-D- gluconate (25DKG) to 5-keto-D-gluconate (5KDG)%2C 2-keto-D-gluconate (2KDG) to D-gluconate%2C and 2-keto-L-gulonate (2KLG) to L-idonate (IA)%3B Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B KEGG: lsa:LSA0922 D-3-phosphoglycerate dehydrogenase gene gene1610 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01611 WSWS_01612 WSWS_01612 WSWS_01612 1657272 1658561 - Aspartate-proton symporter Uptake of L-aspartate with the concomitant import of a proton. Can also transport aspartate hydroxamate and L-glutamate with lower affinity and efficiency. Belongs to the amino acid-polyamine-organocation (APC) superfamily. AGT (TC 2. A. 3. 11) family gene gene1611 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01612 WSWS_01613 WSWS_01613 WSWS_01613 1658749 1659270 + hypothetical protein gene gene1612 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01613 WSWS_01614 WSWS_01614 WSWS_01614 1659356 1659431 + tRNA-Lys tRNA gene1613 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01614 WSWS_01615 WSWS_01615 WSWS_01615 1659534 1660649 + UPF0118 membrane protein YueF Belongs to the UPF0118 (PerM) family gene gene1614 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01615 WSWS_01616 WSWS_01616 WSWS_01616 1660706 1661944 - Aminopeptidase PepS Exhibits a high specificity towards peptides possessing arginine or aromatic amino acids at the N-terminus. Could be involved both in bacterial growth by supplying amino acids. Belongs to the peptidase M29 family%3B KEGG: sag:SAG1472 aminopeptidase%3B Aminopeptidases gene gene1615 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01616 WSWS_01617 WSWS_01617 WSWS_01617 1662062 1663912 - Nitronate monooxygenase KEGG: cdb:CDBH8_1365 nitronate monooxygenase gene gene1616 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01617 WSWS_01618 WSWS_01618 WSWS_01618 1663915 1664580 - ADP-dependent NAD(P)H-hydrate dehydratase Catalyzes the epimerization of the S- and R-forms of NAD(P)HX%2C a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX%3B Belongs to the NnrE/AIBP family%3B Contains 1 YjeF N-terminal domain%3B KEGG: mhc:MARHY2662 ADP-dependent NAD(P)H-hydrate dehydratase gene gene1617 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01618 WSWS_01619 WSWS_01619 WSWS_01619 1664945 1665643 + Aquaporin Z Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)%3B Belongs to the MIP/aquaporin (TC 1. A. 8) family gene gene1618 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01619 WSWS_01620 WSWS_01620 WSWS_01620 1665754 1666668 + NADPH:quinone reductase Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily%3B KEGG: cel:CELE_F39B2. 3 NADPH2:quinone reductase gene gene1619 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01620 WSWS_01621 WSWS_01621 pgpA pgpA 1666706 1667191 + Phosphatidylglycerophosphatase To B. subtilis YpjQ%3B KEGG: acl:ACL_0288 phosphatidylglycerophosphatase A gene gene1620 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01621 WSWS_01622 WSWS_01622 WSWS_01622 1667472 1668887 + High affinity cationic amino acid transporter High-affinity%2C low capacity permease involved in the transport of the cationic amino acids (arginine%2C lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor%3B Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2. A. 3. 3) family gene gene1621 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01622 WSWS_01623 WSWS_01623 ansA ansA 1669001 1669993 + Asparaginase Belongs to the asparaginase 1 family%3B Contains 1 asparaginase/glutaminase domain%3B KEGG: wce:WS08_1207 L-asparaginase gene gene1622 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01623 WSWS_01624 WSWS_01624 WSWS_01624 1670003 1670338 + uncharacterized protein gene gene1623 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01624 WSWS_01625 WSWS_01625 coq5 coq5 1670386 1671084 + 2-methoxy-6-polyprenyl-1%2C4-benzoquinol methylase Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family%3B KEGG: cin:100179275 2-methoxy-6-polyprenyl-1%2C4-benzoquinol methylase gene gene1624 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01625 WSWS_01626 WSWS_01626 menI menI 1671129 1671500 - 1%2C4-dihydroxy-2-naphthoyl-CoA hydrolase Belongs to the thioesterase PaaI family%3B KEGG: bbd:Belba_2244 1%2C4-dihydroxy-2-naphthoyl-CoA hydrolase gene gene1625 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01626 WSWS_01627 WSWS_01627 menB menB 1671579 1672403 + 1%2C4-dihydroxy-2-naphthoyl-CoA synthase Involved in the biosynthesis of phylloquinone (vitamin K1). Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1%2C4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA) (By similarity)%3B Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily%3B KEGG: nge:Natgr_0067 naphthoate synthase gene gene1626 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01627 WSWS_01628 WSWS_01628 menE menE 1672466 1673908 + o-succinylbenzoate--CoA ligase Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA)%3B Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily%3B KEGG: lci:LCK_01676 O-succinylbenzoic acid--CoA ligase gene gene1627 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01628 WSWS_01629 WSWS_01629 WSWS_01629 1674229 1674927 + Transcriptional regulatory protein CiaR Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1628 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01629 WSWS_01630 WSWS_01630 ciaH ciaH 1674928 1676157 + Histidine kinase Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR (By similarity)%3B Contains 1 histidine kinase domain%3B KEGG: wce:WS08_1199 two-component system%2C OmpR family%2C sensor histidine kinase CiaH gene gene1629 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01630 WSWS_01631 WSWS_01631 WSWS_01631 1676157 1676654 + uncharacterized protein gene gene1630 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01631 WSWS_01632 WSWS_01632 WSWS_01632 1676683 1677033 + hypothetical protein gene gene1631 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01632 WSWS_01633 WSWS_01633 WSWS_01633 1677178 1679001 + DNA helicase DNA helicase%3B Belongs to the helicase family. RecQ subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B Contains 1 HRDC domain%3B KEGG: dja:HY57_07695 ATP-dependent DNA helicase RecQ gene gene1632 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01633 WSWS_01634 WSWS_01634 aroE aroE 1679118 1679939 + Shikimate dehydrogenase Involved in the biosynthesis of the chorismate%2C which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)%3B Belongs to the shikimate dehydrogenase family%3B KEGG: bsu:BSU25660 shikimate dehydrogenase gene gene1633 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01634 WSWS_01635 WSWS_01635 WSWS_01635 1679943 1680920 + 3-deoxy-7-phosphoheptulonate synthase Catalyzes the condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP). Belongs to the class-I DAHP synthase family%3B KEGG: lme:LEUM_1167 3-deoxy-7-phosphoheptulonate synthase gene gene1634 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01635 WSWS_01636 WSWS_01636 aroB aroB 1680925 1681992 + 3-dehydroquinate synthase Belongs to the dehydroquinate synthase family%3B KEGG: lhk:LHK_02957 3-dehydroquinate synthase gene gene1635 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01636 WSWS_01637 WSWS_01637 aroC aroC 1681992 1683170 + Chorismate synthase Catalyzes the anti-1%2C4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate%2C which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system%3B Belongs to the chorismate synthase family%3B KEGG: sua:Saut_2103 chorismate synthase gene gene1636 http://www.ncbi.nlm.nih.gov/gene/?term=WSWS_01637