locus-tag	class	description
L3V65_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L3V65_00010	COG0592	DNA-directed DNA polymerase activity
L3V65_00015	COG2501	S4 domain
L3V65_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L3V65_00030	COG0187	DNA topoisomerase II activity
L3V65_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L3V65_00040	COG3437	response regulator, receiver
L3V65_00075	COG1982	Orn Lys Arg decarboxylase major
L3V65_00085	COG3870	Protein conserved in bacteria
L3V65_00090	COG1728	Protein conserved in bacteria
L3V65_00095	COG0470	DNA polymerase III
L3V65_00100	COG1774	PSP1 C-terminal conserved region
L3V65_00105	COG4467	Involved in initiation control of chromosome replication
L3V65_00110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L3V65_00115	COG2827	Endonuclease containing a URI domain
L3V65_00120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L3V65_00135	COG0084	hydrolase, TatD family'
L3V65_00155	COG4466	Protein conserved in bacteria
L3V65_00170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L3V65_00175	COG0251	oxidation-reduction process
L3V65_00195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L3V65_00200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L3V65_00205	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L3V65_00220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L3V65_00225	COG2002	toxin-antitoxin pair type II binding
L3V65_00230	COG2244	polysaccharide biosynthetic process
L3V65_00235	COG3956	TIGRFAM MazG family protein
L3V65_00240	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L3V65_00260	COG1098	S1 RNA binding domain
L3V65_00270	COG2208	phosphoserine phosphatase activity
L3V65_00275	COG2304	oxidoreductase activity
L3V65_00280	COG0515	serine threonine protein kinase
L3V65_00285	COG0037	tRNA processing
L3V65_00290	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L3V65_00295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L3V65_00300	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L3V65_00305	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L3V65_00310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L3V65_00315	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L3V65_00320	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L3V65_00325	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L3V65_00405	COG0516	GMP reductase activity
L3V65_00405	COG0517	IMP dehydrogenase activity
L3V65_00420	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
L3V65_00425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L3V65_00435	COG1428	Deoxynucleoside kinase
L3V65_00440	COG1428	Deoxynucleoside kinase
L3V65_00450	COG0590	tRNA wobble adenosine to inosine editing
L3V65_00460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L3V65_00465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L3V65_00470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L3V65_00570	COG3880	PFAM UvrB UvrC protein
L3V65_00575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
L3V65_00580	COG0542	response to heat
L3V65_00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L3V65_00590	COG4956	integral membrane protein (PIN domain superfamily)
L3V65_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L3V65_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L3V65_00610	COG1045	serine acetyltransferase
L3V65_00615	COG0215	cysteine-tRNA ligase activity
L3V65_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L3V65_00630	COG3688	RNA-binding protein containing a PIN domain
L3V65_00640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L3V65_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L3V65_00650	COG0250	Participates in transcription elongation, termination and antitermination
L3V65_00655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L3V65_00660	COG0081	regulation of translation
L3V65_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L3V65_00675	COG2813	Specifically methylates the guanine in position
L3V65_00680	COG0085	RNA polymerase activity
L3V65_00690	COG1358	cellular component organization or biogenesis
L3V65_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L3V65_00700	COG0049	tRNA binding
L3V65_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L3V65_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L3V65_00715	COG0051	transcription antitermination factor activity, RNA binding
L3V65_00735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L3V65_00740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L3V65_00750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L3V65_00755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L3V65_00760	COG0255	Belongs to the universal ribosomal protein uL29 family
L3V65_00770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L3V65_00780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L3V65_00785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L3V65_00790	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L3V65_00795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L3V65_00800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L3V65_00805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L3V65_00815	COG0200	Binds to the 23S rRNA
L3V65_00820	COG0201	protein transport
L3V65_00825	COG0563	adenylate kinase activity
L3V65_00830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L3V65_00835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L3V65_00840	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L3V65_00845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L3V65_00850	COG0202	RNA polymerase activity
L3V65_00855	COG0203	ribosomal protein L17
L3V65_00860	COG1122	ATPase activity
L3V65_00865	COG1122	ATPase activity
L3V65_00870	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L3V65_00880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L3V65_00885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L3V65_00895	COG2046	Belongs to the sulfate adenylyltransferase family
L3V65_00900	COG0529	Catalyzes the synthesis of activated sulfate
L3V65_00905	COG0833	amino acid
L3V65_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
L3V65_00920	COG0489	protein tyrosine kinase activity
L3V65_00930	COG2194	sulfuric ester hydrolase activity
L3V65_00945	COG0662	Cupin 2, conserved barrel domain protein
L3V65_00955	COG0726	polysaccharide deacetylase
L3V65_00965	COG1271	oxidase subunit
L3V65_00970	COG1294	oxidase, subunit
L3V65_00975	COG4988	ABC transporter
L3V65_00980	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L3V65_01055	COG1595	DNA-templated transcription, initiation
L3V65_01065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
L3V65_01070	COG4856	YbbR-like protein
L3V65_01075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L3V65_01080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L3V65_01110	COG2814	Major facilitator Superfamily
L3V65_01115	COG0583	DNA-binding transcription factor activity
L3V65_01125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L3V65_01145	COG3425	synthase
L3V65_01150	COG0183	Belongs to the thiolase family
L3V65_01170	COG1125	glycine betaine transport
L3V65_01170	COG0517	IMP dehydrogenase activity
L3V65_01175	COG1174	glycine betaine transport
L3V65_01200	COG0716	FMN binding
L3V65_01205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L3V65_01215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L3V65_01220	COG2217	Heavy metal translocating P-type atpase
L3V65_01225	COG2217	Heavy metal translocating P-type atpase
L3V65_01235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L3V65_01245	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L3V65_01250	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L3V65_01270	COG2076	Multidrug Resistance protein
L3V65_01275	COG2076	Multidrug Resistance protein
L3V65_01285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3V65_01290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3V65_01295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L3V65_01300	COG1120	ATPase activity
L3V65_01325	COG0217	transcriptional regulatory protein
L3V65_01330	COG1366	Belongs to the anti-sigma-factor antagonist family
L3V65_01355	COG5434	Belongs to the glycosyl hydrolase 28 family
L3V65_01365	COG0175	sulfate reduction
L3V65_01385	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L3V65_01395	COG0371	Dehydrogenase
L3V65_01400	COG0318	PFAM AMP-dependent synthetase and ligase
L3V65_01415	COG0697	spore germination
L3V65_01435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L3V65_01445	COG1216	Glycosyl transferase, family 2
L3V65_01445	COG1442	glycosyl transferase family 8
L3V65_01450	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L3V65_01470	COG0702	epimerase
L3V65_01490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L3V65_01505	COG2848	UPF0210 protein
L3V65_01515	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L3V65_01520	COG5577	PFAM Coat F domain
L3V65_01525	COG0667	Aldo Keto reductase
L3V65_01535	COG1113	amino acid transport
L3V65_01540	COG3104	oligopeptide transport
L3V65_01545	COG0833	amino acid
L3V65_01555	COG3842	ATPase activity
L3V65_01560	COG1176	ABC-type spermidine putrescine transport system, permease component I
L3V65_01565	COG1177	transmembrane transport
L3V65_01580	COG0531	amino acid
L3V65_01585	COG1556	Lactate utilization protein
L3V65_01590	COG1139	Iron-sulfur cluster binding protein
L3V65_01595	COG0247	lactate metabolic process
L3V65_01600	COG0531	amino acid
L3V65_01620	COG0004	ammonium transporteR
L3V65_01635	COG3290	protein histidine kinase activity
L3V65_01640	COG4565	transcriptional regulatory protein
L3V65_01645	COG2851	Citrate transporter
L3V65_01650	COG0463	Glycosyl transferase, family 2
L3V65_01655	COG3973	AAA domain
L3V65_01690	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
L3V65_01695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L3V65_01700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L3V65_01705	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L3V65_01710	COG1301	dicarboxylic acid transport
L3V65_01725	COG1902	pentaerythritol trinitrate reductase activity
L3V65_01745	COG0531	amino acid
L3V65_01755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L3V65_01760	COG0628	permease
L3V65_01770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3V65_01775	COG0765	amino acid transport
L3V65_01780	COG0765	amino acid transport
L3V65_01795	COG1733	regulation of RNA biosynthetic process
L3V65_01800	COG0586	Pfam SNARE associated Golgi protein
L3V65_01805	COG0586	Pfam SNARE associated Golgi protein
L3V65_01820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L3V65_01820	COG0646	methionine synthase
L3V65_01825	COG0646	methionine synthase
L3V65_01825	COG1410	methionine synthase
L3V65_01850	COG3944	biosynthesis protein
L3V65_01855	COG0489	protein tyrosine kinase activity
L3V65_01860	COG4464	protein tyrosine phosphatase activity
L3V65_01865	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L3V65_01870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L3V65_01890	COG1215	transferase activity, transferring glycosyl groups
L3V65_01905	COG0562	UDP-galactopyranose mutase
L3V65_01955	COG1063	alcohol dehydrogenase
L3V65_01960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L3V65_01975	COG4193	domain, Protein
L3V65_01995	COG5504	Zn-dependent protease
L3V65_02010	COG2226	methyltransferase
L3V65_02015	COG5263	repeat protein
L3V65_02015	COG0366	Alpha amylase catalytic
L3V65_02050	COG0658	competence protein
L3V65_02050	COG2333	competence protein COMEC
L3V65_02060	COG3867	Arabinogalactan endo-beta-1,4-galactanase
L3V65_02090	COG0531	amino acid
L3V65_02095	COG1316	TRANSCRIPTIONal
L3V65_02105	COG4989	oxidoreductase activity
L3V65_02120	COG2130	NADP-dependent
L3V65_02140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3V65_02140	COG3711	transcriptional antiterminator
L3V65_02145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3V65_02150	COG1447	Phosphotransferase system cellobiose-specific component IIA
L3V65_02160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3V65_02165	COG2211	Major facilitator Superfamily
L3V65_02165	COG2190	(PTS) system
L3V65_02180	COG2814	Major facilitator Superfamily
L3V65_02190	COG2814	Major facilitator Superfamily
L3V65_02205	COG1174	glycine betaine transport
L3V65_02210	COG1732	Glycine betaine
L3V65_02215	COG1174	glycine betaine transport
L3V65_02220	COG0517	IMP dehydrogenase activity
L3V65_02220	COG1125	glycine betaine transport
L3V65_02225	COG1510	regulation of RNA biosynthetic process
L3V65_02230	COG0110	maltose O-acetyltransferase activity
L3V65_02245	COG4297	protein containing double-stranded beta helix domain
L3V65_02260	COG2272	Belongs to the type-B carboxylesterase lipase family
L3V65_02280	COG0371	Dehydrogenase
L3V65_02290	COG0157	Belongs to the NadC ModD family
L3V65_02295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L3V65_02300	COG1104	cysteine desulfurase activity
L3V65_02315	COG1131	(ABC) transporter
L3V65_02330	COG2116	formate transmembrane transporter activity
L3V65_02345	COG4720	Psort location CytoplasmicMembrane, score
L3V65_02380	COG0584	glycerophosphoryl diester phosphodiesterase
L3V65_02400	COG3639	organic phosphonate transmembrane transporter activity
L3V65_02405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3V65_02410	COG0737	Belongs to the 5'-nucleotidase family
L3V65_02415	COG1363	Peptidase, m42
L3V65_02430	COG1620	l-lactate permease
L3V65_02435	COG2186	Transcriptional regulator
L3V65_02480	COG1486	melibiose metabolic process
L3V65_02490	COG3711	transcriptional antiterminator
L3V65_02490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3V65_02500	COG3711	transcriptional antiterminator
L3V65_02500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3V65_02505	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3V65_02510	COG2723	6-phospho-beta-galactosidase activity
L3V65_02515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3V65_02520	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3V65_02525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L3V65_02540	COG2877	3-deoxy-8-phosphooctulonate synthase activity
L3V65_02550	COG0626	cystathionine gamma-synthase activity
L3V65_02555	COG0626	cystathionine gamma-synthase activity
L3V65_02575	COG1653	transport
L3V65_02580	COG2207	Transcriptional regulator
L3V65_02600	COG0604	alcohol dehydrogenase
L3V65_02605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L3V65_02610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L3V65_02630	COG1028	Short-chain dehydrogenase reductase Sdr
L3V65_02635	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L3V65_02645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L3V65_02655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L3V65_02660	COG1316	TRANSCRIPTIONal
L3V65_02670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L3V65_02675	COG1554	hydrolase, family 65, central catalytic
L3V65_02685	COG1609	Transcriptional regulator
L3V65_02700	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L3V65_02715	COG1388	LysM domain
L3V65_02715	COG3584	3D domain protein
L3V65_02730	COG0011	TIGRFAM Protein of
L3V65_02735	COG2706	6-phosphogluconolactonase activity
L3V65_02745	COG3933	PFAM sigma-54 factor interaction domain-containing protein
L3V65_02745	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
L3V65_02750	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3V65_02750	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3V65_02760	COG3715	PTS system
L3V65_02765	COG3716	PTS system mannose fructose sorbose family IID component
L3V65_02780	COG2079	MmgE PrpD family protein
L3V65_02785	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L3V65_02795	COG0154	amidase activity
L3V65_02805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L3V65_02815	COG1116	anion transmembrane transporter activity
L3V65_02820	COG0083	homoserine kinase activity
L3V65_02825	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L3V65_02830	COG0460	homoserine dehydrogenase
L3V65_02835	COG0010	Belongs to the arginase family
L3V65_02845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L3V65_02850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L3V65_02860	COG4145	pantothenate transmembrane transporter activity
L3V65_02875	COG1012	belongs to the aldehyde dehydrogenase family
L3V65_02875	COG1454	alcohol dehydrogenase
L3V65_02890	COG0791	NLP P60 protein
L3V65_02890	COG1388	LysM domain
L3V65_02895	COG0024	Methionine aminopeptidase
L3V65_02900	COG1268	BioY protein
L3V65_02905	COG1028	Short-chain dehydrogenase reductase Sdr
L3V65_02910	COG2746	aminoglycoside 3-N-acetyltransferase activity
L3V65_02915	COG2244	polysaccharide biosynthetic process
L3V65_02920	COG0589	response to stress
L3V65_02935	COG0535	radical SAM domain protein
L3V65_02945	COG1609	Transcriptional regulator
L3V65_02955	COG0561	phosphatase activity
L3V65_02985	COG0431	NADPH-dependent FMN reductase
L3V65_02995	COG0420	3'-5' exonuclease activity
L3V65_03000	COG4717	serine-type aminopeptidase activity
L3V65_03010	COG1250	3-hydroxyacyl-CoA dehydrogenase
L3V65_03015	COG0534	Mate efflux family protein
L3V65_03030	COG0789	Transcriptional regulator
L3V65_03035	COG0436	Aminotransferase
L3V65_03040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L3V65_03050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L3V65_03060	COG2226	methyltransferase
L3V65_03080	COG1090	epimerase
L3V65_03085	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L3V65_03155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L3V65_03160	COG1113	amino acid transport
L3V65_03165	COG2814	Major facilitator Superfamily
L3V65_03175	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
L3V65_03190	COG1960	acyl-CoA dehydrogenase activity
L3V65_03200	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L3V65_03205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L3V65_03210	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
L3V65_03215	COG2017	converts alpha-aldose to the beta-anomer
L3V65_03220	COG1609	Transcriptional regulator
L3V65_03240	COG2996	Protein conserved in bacteria
L3V65_03245	COG0346	lactoylglutathione lyase activity
L3V65_03250	COG1482	cell wall glycoprotein biosynthetic process
L3V65_03260	COG0477	Major facilitator Superfamily
L3V65_03265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L3V65_03275	COG2188	Transcriptional regulator
L3V65_03280	COG0791	NLP P60 protein
L3V65_03280	COG1388	LysM domain
L3V65_03290	COG0768	penicillin binding
L3V65_03295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L3V65_03300	COG1739	Uncharacterized protein family UPF0029
L3V65_03310	COG2197	response regulator
L3V65_03315	COG0531	amino acid
L3V65_03320	COG1307	EDD domain protein, DegV family
L3V65_03325	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
L3V65_03330	COG1040	competence protein
L3V65_03350	COG4786	Flagellar basal body rod
L3V65_03350	COG1256	bacterial-type flagellum assembly
L3V65_03355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L3V65_03365	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L3V65_03370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L3V65_03375	COG0457	Tetratricopeptide repeat
L3V65_03375	COG0463	Glycosyl transferase, family 2
L3V65_03395	COG1067	ATP-dependent peptidase activity
L3V65_03420	COG1067	ATP-dependent peptidase activity
L3V65_03435	COG2094	Belongs to the DNA glycosylase MPG family
L3V65_03445	COG1334	flagellar protein FlaG
L3V65_03450	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
L3V65_03455	COG1516	flagellar protein fliS
L3V65_03480	COG0653	protein targeting
L3V65_03490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L3V65_03525	COG1136	(ABC) transporter
L3V65_03525	COG0577	efflux transmembrane transporter activity
L3V65_03530	COG2884	Cell division ATP-binding protein ftsE
L3V65_03535	COG2177	Part of the ABC transporter FtsEX involved in
L3V65_03540	COG0739	heme binding
L3V65_03555	COG0460	homoserine dehydrogenase
L3V65_03560	COG3409	Peptidoglycan-binding domain 1 protein
L3V65_03560	COG0793	Belongs to the peptidase S41A family
L3V65_03565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L3V65_03570	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3V65_03575	COG4605	iron ion homeostasis
L3V65_03580	COG4604	ABC transporter, ATP-binding protein
L3V65_03585	COG4607	ABC-type enterochelin transport system periplasmic component
L3V65_03605	COG0745	RESPONSE REGULATOR receiver
L3V65_03610	COG5002	protein histidine kinase activity
L3V65_03615	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L3V65_03625	COG0573	inorganic phosphate transmembrane transporter activity
L3V65_03630	COG0581	inorganic phosphate transmembrane transporter activity
L3V65_03640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L3V65_03680	COG0556	nucleotide-excision repair
L3V65_03685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L3V65_03695	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L3V65_03705	COG0463	Glycosyl transferase, family 2
L3V65_03715	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L3V65_03720	COG0463	Glycosyl transferase, family 2
L3V65_03720	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L3V65_03725	COG1682	transport, permease protein
L3V65_03740	COG3595	metallopeptidase activity
L3V65_03750	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
L3V65_03755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L3V65_03760	COG0546	phosphoglycolate phosphatase activity
L3V65_03765	COG0110	maltose O-acetyltransferase activity
L3V65_03770	COG0457	Tetratricopeptide repeat
L3V65_03775	COG0492	ferredoxin-NADP+ reductase activity
L3V65_03785	COG1051	belongs to the nudix hydrolase family
L3V65_03790	COG1660	Displays ATPase and GTPase activities
L3V65_03795	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L3V65_03800	COG1481	regulation of sporulation
L3V65_03805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3V65_03840	COG3842	ATPase activity
L3V65_03845	COG2508	Transcriptional regulator
L3V65_03855	COG0189	ligase activity
L3V65_03860	COG0189	ligase activity
L3V65_03870	COG4399	Belongs to the UPF0754 family
L3V65_03880	COG0561	phosphatase activity
L3V65_03885	COG1024	Enoyl-CoA hydratase
L3V65_03895	COG0861	Integral membrane protein TerC family
L3V65_03900	COG0701	Predicted permease
L3V65_03905	COG3689	TIGRFAM TIGR03943 family protein
L3V65_03910	COG0420	3'-5' exonuclease activity
L3V65_03915	COG4717	serine-type aminopeptidase activity
L3V65_03920	COG3481	metal-dependent phosphohydrolase, HD sub domain
L3V65_03930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L3V65_03945	COG1846	Transcriptional regulator
L3V65_03965	COG0537	adenosine 5'-monophosphoramidase activity
L3V65_03970	COG1131	(ABC) transporter
L3V65_03975	COG4473	ABC transporter
L3V65_03980	COG1473	amidohydrolase
L3V65_03985	COG3069	C4-dicarboxylate transmembrane transporter activity
L3V65_03990	COG2329	Antibiotic biosynthesis monooxygenase
L3V65_03995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L3V65_04000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L3V65_04005	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L3V65_04010	COG1309	transcriptional regulator
L3V65_04015	COG1511	domain protein
L3V65_04025	COG0697	spore germination
L3V65_04035	COG1999	signal sequence binding
L3V65_04050	COG0095	Lipoate-protein ligase
L3V65_04065	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L3V65_04075	COG0501	Belongs to the peptidase M48B family
L3V65_04085	COG4903	ComK protein
L3V65_04095	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
L3V65_04100	COG1074	ATP-dependent DNA helicase activity
L3V65_04135	COG2311	Membrane
L3V65_04140	COG0179	Fumarylacetoacetate (FAA) hydrolase
L3V65_04155	COG1307	EDD domain protein, DegV family
L3V65_04175	COG2151	metal-sulfur cluster biosynthetic enzyme
L3V65_04205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L3V65_04210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L3V65_04225	COG4608	Belongs to the ABC transporter superfamily
L3V65_04230	COG0601	transmembrane transport
L3V65_04250	COG0180	Tryptophanyl-tRNA synthetase
L3V65_04265	COG4166	transmembrane transport
L3V65_04270	COG0601	transmembrane transport
L3V65_04275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3V65_04280	COG0444	Belongs to the ABC transporter superfamily
L3V65_04285	COG4608	Belongs to the ABC transporter superfamily
L3V65_04290	COG1393	Belongs to the ArsC family
L3V65_04295	COG4862	establishment of competence for transformation
L3V65_04300	COG4469	Competence protein
L3V65_04305	COG1164	Oligoendopeptidase f
L3V65_04315	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L3V65_04320	COG2346	COG2346, Truncated hemoglobins
L3V65_04325	COG0741	lytic transglycosylase activity
L3V65_04330	COG4116	CYTH
L3V65_04340	COG2357	RelA SpoT domain protein
L3V65_04350	COG0564	pseudouridine synthase activity
L3V65_04355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L3V65_04360	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L3V65_04395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L3V65_04420	COG2153	protein acetylation
L3V65_04430	COG2382	esterase
L3V65_04445	COG1940	carbohydrate kinase activity
L3V65_04450	COG4152	abc transporter atp-binding protein
L3V65_04455	COG1668	transmembrane transport
L3V65_04465	COG3579	cysteine-type endopeptidase activity
L3V65_04490	COG2059	Chromate
L3V65_04495	COG2059	Chromate
L3V65_04500	COG1522	sequence-specific DNA binding
L3V65_04545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L3V65_04550	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L3V65_04570	COG0477	Major facilitator Superfamily
L3V65_04580	COG1959	2 iron, 2 sulfur cluster binding
L3V65_04595	COG0730	response to heat
L3V65_04600	COG0783	Belongs to the Dps family
L3V65_04605	COG0673	inositol 2-dehydrogenase activity
L3V65_04610	COG3852	Histidine kinase
L3V65_04615	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L3V65_04625	COG0861	Integral membrane protein TerC family
L3V65_04645	COG5002	protein histidine kinase activity
L3V65_04650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L3V65_04665	COG0542	response to heat
L3V65_04670	COG3949	Membrane
L3V65_04690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3V65_04705	COG2084	Dehydrogenase
L3V65_04710	COG0436	Aminotransferase
L3V65_04715	COG0784	Response regulator, receiver
L3V65_04715	COG0835	chemotaxis
L3V65_04725	COG1033	growth of symbiont in host cell
L3V65_04725	COG2409	Drug exporters of the RND superfamily
L3V65_04750	COG4703	Protein of unknown function (DUF1797)
L3V65_04755	COG0517	IMP dehydrogenase activity
L3V65_04760	COG0583	DNA-binding transcription factor activity
L3V65_04765	COG2171	N-acyltransferase activity
L3V65_04770	COG1473	amidohydrolase
L3V65_04780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L3V65_04820	COG1982	Orn Lys Arg decarboxylase major
L3V65_04840	COG0483	inositol monophosphate 1-phosphatase activity
L3V65_04850	COG1217	gtp-binding protein TYPA
L3V65_04860	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L3V65_04865	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L3V65_04880	COG4838	Belongs to the UPF0358 family
L3V65_04885	COG0772	Belongs to the SEDS family
L3V65_04890	COG1612	heme a metabolic process
L3V65_04895	COG0109	protoheme IX farnesyltransferase activity
L3V65_04900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L3V65_04900	COG2010	Cytochrome c
L3V65_04915	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L3V65_04920	COG3336	cytochrome c oxidase
L3V65_04930	COG2340	Cysteine-rich secretory protein family
L3V65_04955	COG3679	Belongs to the UPF0342 family
L3V65_04960	COG4471	UPF0298 protein
L3V65_04970	COG0742	ribosomal rna small subunit methyltransferase
L3V65_04975	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L3V65_04980	COG3314	Sporulation integral membrane protein YlbJ
L3V65_04985	COG1752	Esterase of the alpha-beta hydrolase superfamily
L3V65_04990	COG3480	Lon protease (S16) C-terminal proteolytic domain
L3V65_04995	COG1323	Belongs to the UPF0348 family
L3V65_05000	COG1399	metal-binding, possibly nucleic acid-binding protein
L3V65_05005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L3V65_05015	COG0454	-acetyltransferase
L3V65_05020	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L3V65_05025	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
L3V65_05030	COG2001	Belongs to the MraZ family
L3V65_05035	COG0275	rRNA processing
L3V65_05040	COG4839	cell division protein FtsL
L3V65_05045	COG0768	penicillin binding
L3V65_05050	COG0768	penicillin binding
L3V65_05065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L3V65_05070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L3V65_05075	COG0772	Belongs to the SEDS family
L3V65_05080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L3V65_05085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L3V65_05090	COG0849	cell division
L3V65_05095	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L3V65_05105	COG1191	sigma factor activity
L3V65_05110	COG1191	sigma factor activity
L3V65_05115	COG1873	PFAM PRC-barrel domain
L3V65_05120	COG3584	3D domain protein
L3V65_05120	COG1388	LysM domain
L3V65_05130	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L3V65_05135	COG1799	cell septum assembly
L3V65_05140	COG0762	integral membrane protein
L3V65_05145	COG2302	S4 RNA-binding domain
L3V65_05150	COG3599	regulation of cell shape
L3V65_05170	COG0564	pseudouridine synthase activity
L3V65_05175	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L3V65_05180	COG0540	Belongs to the ATCase OTCase family
L3V65_05185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L3V65_05200	COG0543	2 iron, 2 sulfur cluster binding
L3V65_05205	COG0167	dihydroorotate dehydrogenase activity
L3V65_05210	COG0284	orotidine-5'-phosphate decarboxylase activity
L3V65_05215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L3V65_05235	COG1803	Methylglyoxal synthase
L3V65_05240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L3V65_05245	COG0477	Major facilitator Superfamily
L3V65_05250	COG0477	Major facilitator Superfamily
L3V65_05255	COG0628	permease
L3V65_05265	COG2211	Major facilitator Superfamily
L3V65_05275	COG0720	synthase
L3V65_05285	COG0385	Bile acid
L3V65_05295	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L3V65_05300	COG1561	YicC-like family, N-terminal region
L3V65_05305	COG2052	Domain of unknown function (DUF370)
L3V65_05310	COG0194	GDP metabolic process
L3V65_05315	COG1758	RNA polymerase activity
L3V65_05320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L3V65_05325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L3V65_05330	COG0242	peptide deformylase activity
L3V65_05335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L3V65_05345	COG0631	protein serine/threonine phosphatase activity
L3V65_05350	COG0515	serine threonine protein kinase
L3V65_05350	COG2815	serine threonine protein kinase
L3V65_05355	COG1162	GTPase activity
L3V65_05360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L3V65_05365	COG1564	THIamine pyrophosphokinase
L3V65_05375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L3V65_05380	COG1302	Protein conserved in bacteria
L3V65_05385	COG1461	Dihydroxyacetone kinase
L3V65_05390	COG1760	l-serine dehydratase
L3V65_05395	COG1760	l-serine dehydratase
L3V65_05400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L3V65_05405	COG1349	DNA-binding transcription factor activity
L3V65_05410	COG0416	fatty acid biosynthetic process
L3V65_05415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L3V65_05420	COG1028	Short-chain dehydrogenase reductase Sdr
L3V65_05430	COG0571	ribonuclease III activity
L3V65_05435	COG1196	nuclear chromosome segregation
L3V65_05440	COG0552	protein localization to endoplasmic reticulum
L3V65_05445	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
L3V65_05450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L3V65_05460	COG1837	Belongs to the UPF0109 family
L3V65_05470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L3V65_05475	COG0336	Belongs to the RNA methyltransferase TrmD family
L3V65_05490	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L3V65_05505	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L3V65_05510	COG0045	succinate-CoA ligase (ADP-forming) activity
L3V65_05515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L3V65_05520	COG0758	DNA mediated transformation
L3V65_05525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L3V65_05535	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
L3V65_05545	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L3V65_05550	COG1815	bacterial-type flagellum-dependent cell motility
L3V65_05555	COG1558	bacterial-type flagellum-dependent cell motility
L3V65_05560	COG1677	Flagellar hook-basal body complex protein FliE
L3V65_05565	COG1766	The M ring may be actively involved in energy transduction
L3V65_05570	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L3V65_05575	COG1317	bacterial-type flagellum organization
L3V65_05580	COG1157	protein secretion by the type III secretion system
L3V65_05585	COG2882	bacterial-type flagellum organization
L3V65_05600	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
L3V65_05610	COG4786	Flagellar basal body rod
L3V65_05620	COG1580	Controls the rotational direction of flagella during chemotaxis
L3V65_05625	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L3V65_05630	COG1776	CheC inhibitor of MCP methylation
L3V65_05630	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L3V65_05635	COG2201	protein-glutamate methylesterase activity
L3V65_05640	COG3190	flagellar
L3V65_05645	COG1338	Plays a role in the flagellum-specific transport system
L3V65_05650	COG1987	bacterial-type flagellum assembly
L3V65_05655	COG1684	flagellar biosynthetic protein fliR
L3V65_05660	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L3V65_05665	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L3V65_05670	COG1419	protein localization to endoplasmic reticulum
L3V65_05675	COG0455	bacterial-type flagellum organization
L3V65_05680	COG2201	protein-glutamate methylesterase activity
L3V65_05685	COG0643	Histidine kinase
L3V65_05685	COG2198	Histidine kinase
L3V65_05690	COG0835	chemotaxis
L3V65_05695	COG1776	CheC inhibitor of MCP methylation
L3V65_05705	COG1191	sigma factor activity
L3V65_05715	COG0052	Belongs to the universal ribosomal protein uS2 family
L3V65_05720	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L3V65_05725	COG0528	UMP kinase activity
L3V65_05730	COG0233	cytoplasmic translational termination
L3V65_05735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L3V65_05740	COG4589	Belongs to the CDS family
L3V65_05745	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L3V65_05750	COG0750	zinc metalloprotease
L3V65_05755	COG0442	prolyl-tRNA aminoacylation
L3V65_05760	COG2176	DNA-directed DNA polymerase activity
L3V65_05765	COG0779	Required for maturation of 30S ribosomal subunits
L3V65_05770	COG0195	Participates in both transcription termination and antitermination
L3V65_05775	COG2740	Nucleic-acid-binding protein implicated in transcription termination
L3V65_05780	COG1358	cellular component organization or biogenesis
L3V65_05790	COG1550	Protein conserved in bacteria
L3V65_05795	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L3V65_05800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L3V65_05805	COG0196	riboflavin kinase activity
L3V65_05810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L3V65_05815	COG1185	polyribonucleotide nucleotidyltransferase activity
L3V65_05820	COG0726	polysaccharide deacetylase
L3V65_05825	COG0612	Peptidase, M16
L3V65_05830	COG1873	PFAM PRC-barrel domain
L3V65_05835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L3V65_05840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L3V65_05845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L3V65_05850	COG0527	aspartate kinase activity
L3V65_05860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L3V65_05880	COG1744	ABC transporter substrate-binding protein PnrA-like
L3V65_05885	COG3845	ABC transporter
L3V65_05890	COG4603	Belongs to the binding-protein-dependent transport system permease family
L3V65_05895	COG1079	Belongs to the binding-protein-dependent transport system permease family
L3V65_05900	COG0612	Peptidase, M16
L3V65_05905	COG0612	Peptidase, M16
L3V65_05910	COG0300	oxidoreductase activity
L3V65_05925	COG1426	Protein conserved in bacteria
L3V65_05935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L3V65_05940	COG1546	Belongs to the CinA family
L3V65_05940	COG1058	Belongs to the CinA family
L3V65_05950	COG1418	mRNA catabolic process
L3V65_05955	COG1692	metallophosphoesterase
L3V65_05960	COG2359	stage V sporulation protein S
L3V65_05965	COG0826	peptidase U32
L3V65_05970	COG0826	peptidase U32
L3V65_05980	COG0531	amino acid
L3V65_05985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L3V65_05990	COG4550	Control of competence regulator ComK, YlbF/YmcA
L3V65_06000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L3V65_06005	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L3V65_06020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L3V65_06030	COG0464	growth
L3V65_06035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L3V65_06040	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
L3V65_06045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L3V65_06070	COG1321	iron dependent repressor
L3V65_06075	COG2759	Belongs to the formate--tetrahydrofolate ligase family
L3V65_06085	COG0488	(ABC) transporter
L3V65_06090	COG1413	lyase activity
L3V65_06105	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L3V65_06110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L3V65_06115	COG1272	protein, Hemolysin III
L3V65_06120	COG2755	lipolytic protein G-D-S-L family
L3V65_06130	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
L3V65_06130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L3V65_06135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L3V65_06140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L3V65_06150	COG0840	transmembrane signaling receptor activity
L3V65_06155	COG4479	Belongs to the UPF0346 family
L3V65_06170	COG1876	peptidase activity
L3V65_06175	COG3409	Peptidoglycan-binding domain 1 protein
L3V65_06175	COG0793	Belongs to the peptidase S41A family
L3V65_06180	COG1846	Transcriptional regulator
L3V65_06185	COG2340	Cysteine-rich secretory protein family
L3V65_06190	COG0534	Mate efflux family protein
L3V65_06200	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L3V65_06205	COG1793	dna ligase
L3V65_06205	COG3285	dna ligase
L3V65_06210	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
L3V65_06215	COG0671	phosphoesterase, PA-phosphatase related
L3V65_06220	COG1368	sulfuric ester hydrolase activity
L3V65_06225	COG1331	Highly conserved protein containing a thioredoxin domain
L3V65_06230	COG2814	Major facilitator Superfamily
L3V65_06235	COG0745	RESPONSE REGULATOR receiver
L3V65_06240	COG5002	protein histidine kinase activity
L3V65_06250	COG0567	Dehydrogenase, E1 component
L3V65_06255	COG0508	dehydrogenase complex catalyzes the overall conversion of
L3V65_06260	COG1012	belongs to the aldehyde dehydrogenase family
L3V65_06280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L3V65_06290	COG1054	Belongs to the UPF0176 family
L3V65_06295	COG2135	peptidase activity
L3V65_06310	COG0516	GMP reductase activity
L3V65_06310	COG0517	IMP dehydrogenase activity
L3V65_06320	COG1388	LysM domain
L3V65_06320	COG3584	3D domain protein
L3V65_06325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L3V65_06335	COG0598	Magnesium transport protein CorA
L3V65_06345	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
L3V65_06350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L3V65_06360	COG0131	Imidazoleglycerol-phosphate dehydratase
L3V65_06365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L3V65_06380	COG0140	phosphoribosyl-ATP diphosphatase activity
L3V65_06380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L3V65_06390	COG2391	methyltransferase activity
L3V65_06395	COG2962	Rard protein
L3V65_06400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L3V65_06405	COG0569	domain protein
L3V65_06425	COG2807	transmembrane transport
L3V65_06430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L3V65_06440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L3V65_06450	COG1278	Cold shock
L3V65_06455	COG0302	gtp cyclohydrolase
L3V65_06460	COG3634	alkyl hydroperoxide reductase activity
L3V65_06475	COG0577	efflux transmembrane transporter activity
L3V65_06480	COG1136	(ABC) transporter
L3V65_06485	COG0642	Histidine kinase
L3V65_06490	COG0745	RESPONSE REGULATOR receiver
L3V65_06495	COG5039	Polysaccharide pyruvyl transferase
L3V65_06525	COG0477	Major facilitator Superfamily
L3V65_06535	COG1132	(ABC) transporter
L3V65_06540	COG1132	(ABC) transporter
L3V65_06550	COG1380	Effector of murein hydrolase LrgA
L3V65_06555	COG1346	cytolysis
L3V65_06560	COG0318	PFAM AMP-dependent synthetase and ligase
L3V65_06585	COG2309	aminopeptidase activity
L3V65_06595	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L3V65_06615	COG0824	Thioesterase
L3V65_06625	COG4841	protein insertion into membrane
L3V65_06630	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L3V65_06635	COG1832	CoA-binding protein
L3V65_06640	COG0187	DNA topoisomerase II activity
L3V65_06645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L3V65_06660	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
L3V65_06665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L3V65_06665	COG0574	Belongs to the PEP-utilizing enzyme family
L3V65_06690	COG2070	2-Nitropropane dioxygenase
L3V65_06695	COG0681	Belongs to the peptidase S26 family
L3V65_06700	COG0456	acetyltransferase
L3V65_06705	COG1028	Short-chain dehydrogenase reductase Sdr
L3V65_06710	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
L3V65_06715	COG0351	phosphomethylpyrimidine kinase
L3V65_06720	COG0352	thiamine-phosphate diphosphorylase activity
L3V65_06730	COG2258	MOSC domain
L3V65_06755	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L3V65_06760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L3V65_06795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L3V65_06800	COG0022	dehydrogenase e1 component
L3V65_06805	COG0508	dehydrogenase complex catalyzes the overall conversion of
L3V65_06810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L3V65_06815	COG3284	Transcriptional regulator
L3V65_06820	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
L3V65_06820	COG3264	Mechanosensitive ion channel
L3V65_06835	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
L3V65_06860	COG0561	phosphatase activity
L3V65_06865	COG2322	membrane
L3V65_06880	COG0039	L-malate dehydrogenase activity
L3V65_06920	COG0589	response to stress
L3V65_06940	COG0583	DNA-binding transcription factor activity
L3V65_06960	COG1028	Short-chain dehydrogenase reductase Sdr
L3V65_06965	COG2223	nitrite transmembrane transporter activity
L3V65_06970	COG3773	Cell wall hydrolase
L3V65_06975	COG0708	Exodeoxyribonuclease III
L3V65_06980	COG2084	Dehydrogenase
L3V65_06985	COG0297	glycogen (starch) synthase activity
L3V65_06995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L3V65_07000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L3V65_07020	COG1247	-acetyltransferase
L3V65_07025	COG0494	nUDIX hydrolase
L3V65_07030	COG1914	H( )-stimulated, divalent metal cation uptake system
L3V65_07035	COG0783	Belongs to the Dps family
L3V65_07045	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L3V65_07050	COG1131	(ABC) transporter
L3V65_07075	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L3V65_07095	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
L3V65_07100	COG0709	Synthesizes selenophosphate from selenide and ATP
L3V65_07110	COG0701	Predicted permease
L3V65_07115	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L3V65_07120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L3V65_07130	COG1252	NADH dehydrogenase
L3V65_07135	COG2404	hydrolase activity, acting on ester bonds
L3V65_07145	COG4990	cell redox homeostasis
L3V65_07150	COG0789	Transcriptional regulator
L3V65_07175	COG0436	Aminotransferase
L3V65_07180	COG0165	Argininosuccinate lyase
L3V65_07185	COG0137	argininosuccinate synthase activity
L3V65_07190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L3V65_07195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L3V65_07200	COG0505	Belongs to the CarA family
L3V65_07205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L3V65_07210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L3V65_07215	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L3V65_07220	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L3V65_07275	COG1619	proteins homologs of microcin C7 resistance protein MccF
L3V65_07280	COG2027	D-alanyl-D-alanine carboxypeptidase
L3V65_07285	COG0204	Acyl-transferase
L3V65_07295	COG4846	Membrane protein involved in cytochrome C biogenesis
L3V65_07300	COG2201	protein-glutamate methylesterase activity
L3V65_07305	COG0785	Cytochrome C biogenesis protein
L3V65_07310	COG3763	UPF0154 protein
L3V65_07325	COG4224	UPF0291 protein
L3V65_07330	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L3V65_07340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L3V65_07345	COG0174	glutamine synthetase
L3V65_07350	COG0789	Transcriptional regulator
L3V65_07355	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L3V65_07370	COG2233	PERMEase
L3V65_07380	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
L3V65_07385	COG0116	Belongs to the methyltransferase superfamily
L3V65_07400	COG4474	Belongs to the UPF0398 family
L3V65_07410	COG3359	exonuclease
L3V65_07415	COG1205	dead DEAH box helicase
L3V65_07415	COG1111	helicase
L3V65_07420	COG0071	Belongs to the small heat shock protein (HSP20) family
L3V65_07445	COG3331	DNA recombination
L3V65_07450	COG4499	WXG100 protein secretion system (Wss), protein YukC
L3V65_07450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L3V65_07455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L3V65_07460	COG3935	DnaD domain protein
L3V65_07465	COG0017	Asparaginyl-tRNA synthetase
L3V65_07480	COG1199	ATP-dependent helicase activity
L3V65_07480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L3V65_07485	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
L3V65_07490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L3V65_07510	COG0438	transferase activity, transferring glycosyl groups
L3V65_07515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L3V65_07520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L3V65_07525	COG1694	Mazg nucleotide pyrophosphohydrolase
L3V65_07530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L3V65_07545	COG2738	Putative neutral zinc metallopeptidase
L3V65_07555	COG4347	Protein of unknown function (DUF1405)
L3V65_07580	COG5582	Belongs to the UPF0302 family
L3V65_07585	COG0457	Tetratricopeptide repeat
L3V65_07590	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L3V65_07595	COG0287	Prephenate dehydrogenase
L3V65_07600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L3V65_07605	COG4401	Chorismate mutase type I
L3V65_07610	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L3V65_07615	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L3V65_07620	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L3V65_07625	COG0105	UTP biosynthetic process
L3V65_07630	COG0142	geranyltranstransferase activity
L3V65_07635	COG2226	methyltransferase
L3V65_07640	COG0142	geranyltranstransferase activity
L3V65_07650	COG0776	regulation of translation
L3V65_07655	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L3V65_07675	COG1160	GTP binding
L3V65_07690	COG0539	negative regulation of cytoplasmic translation
L3V65_07695	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L3V65_07705	COG2959	enzyme of heme biosynthesis
L3V65_07710	COG3409	Peptidoglycan-binding domain 1 protein
L3V65_07710	COG3773	Cell wall hydrolase
L3V65_07715	COG2339	peptidase activity
L3V65_07720	COG0492	ferredoxin-NADP+ reductase activity
L3V65_07725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L3V65_07735	COG1408	metallophosphoesterase
L3V65_07750	COG3546	catalase activity
L3V65_07765	COG1266	CAAX protease self-immunity
L3V65_07770	COG0514	ATP-dependent DNA helicase (RecQ)
L3V65_07780	COG1141	Ferredoxin
L3V65_07785	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L3V65_07790	COG0741	lytic transglycosylase activity
L3V65_07790	COG0739	heme binding
L3V65_07790	COG1196	nuclear chromosome segregation
L3V65_07795	COG5002	protein histidine kinase activity
L3V65_07800	COG0745	RESPONSE REGULATOR receiver
L3V65_07805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L3V65_07810	COG1333	cytochrome c biogenesis protein
L3V65_07815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L3V65_07820	COG1187	pseudouridine synthase activity
L3V65_07825	COG0700	Nucleoside recognition
L3V65_07830	COG2715	membrane protein required for spore maturation
L3V65_07835	COG1686	Belongs to the peptidase S11 family
L3V65_07840	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L3V65_07865	COG0697	spore germination
L3V65_07885	COG1191	sigma factor activity
L3V65_07900	COG1686	Belongs to the peptidase S11 family
L3V65_07905	COG4974	Belongs to the 'phage' integrase family
L3V65_07915	COG0735	belongs to the Fur family
L3V65_07920	COG1300	Membrane
L3V65_07925	COG1379	DNA repair
L3V65_07940	COG0667	Aldo Keto reductase
L3V65_07950	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
L3V65_07955	COG3853	Toxic anion resistance protein (TelA)
L3V65_07960	COG1073	alpha beta
L3V65_07965	COG3858	chitin binding
L3V65_07965	COG1388	LysM domain
L3V65_07975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L3V65_07980	COG0300	oxidoreductase activity
L3V65_07985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L3V65_07995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L3V65_08010	COG2195	Cleaves the N-terminal amino acid of tripeptides
L3V65_08020	COG1376	ErfK ybiS ycfS ynhG family protein
L3V65_08030	COG1105	Belongs to the carbohydrate kinase PfkB family
L3V65_08035	COG0508	dehydrogenase complex catalyzes the overall conversion of
L3V65_08040	COG0022	dehydrogenase e1 component
L3V65_08045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L3V65_08050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L3V65_08060	COG3290	protein histidine kinase activity
L3V65_08060	COG3829	transcription factor binding
L3V65_08075	COG0584	glycerophosphoryl diester phosphodiesterase
L3V65_08080	COG0745	RESPONSE REGULATOR receiver
L3V65_08085	COG0750	zinc metalloprotease
L3V65_08090	COG0497	DNA recombination
L3V65_08100	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
L3V65_08105	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L3V65_08120	COG1570	exodeoxyribonuclease VII activity
L3V65_08125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L3V65_08135	COG1302	Protein conserved in bacteria
L3V65_08140	COG0439	Biotin carboxylase
L3V65_08145	COG0511	ligase activity, forming carbon-carbon bonds
L3V65_08185	COG3854	ATPases associated with a variety of cellular activities
L3V65_08190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L3V65_08195	COG0006	proline dipeptidase activity
L3V65_08200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L3V65_08210	COG3872	metal-dependent enzyme
L3V65_08220	COG1752	Esterase of the alpha-beta hydrolase superfamily
L3V65_08240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L3V65_08245	COG0095	Lipoate-protein ligase
L3V65_08250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L3V65_08255	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L3V65_08265	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L3V65_08270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L3V65_08285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L3V65_08310	COG4537	Required for transformation and DNA binding
L3V65_08315	COG1459	type II secretion system
L3V65_08320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L3V65_08335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L3V65_08345	COG1940	carbohydrate kinase activity
L3V65_08350	COG4483	Protein conserved in bacteria
L3V65_08355	COG0705	Rhomboid family
L3V65_08355	COG0457	Tetratricopeptide repeat
L3V65_08365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L3V65_08375	COG0768	penicillin binding
L3V65_08380	COG0477	Major facilitator Superfamily
L3V65_08385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L3V65_08395	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L3V65_08400	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
L3V65_08405	COG0735	belongs to the Fur family
L3V65_08410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L3V65_08415	COG1121	(ABC) transporter
L3V65_08425	COG3883	PFAM NLP P60 protein
L3V65_08425	COG0791	NLP P60 protein
L3V65_08430	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
L3V65_08435	COG0513	Belongs to the DEAD box helicase family
L3V65_08455	COG2384	SAM-dependent methyltransferase
L3V65_08460	COG2010	Cytochrome c
L3V65_08470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L3V65_08475	COG0358	DNA primase activity
L3V65_08485	COG0517	IMP dehydrogenase activity
L3V65_08490	COG1381	Involved in DNA repair and RecF pathway recombination
L3V65_08500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L3V65_08505	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L3V65_08510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L3V65_08515	COG1480	7TM receptor with intracellular HD hydrolase
L3V65_08520	COG1702	phosphate starvation-inducible protein PhoH
L3V65_08535	COG1610	YqeY-like protein
L3V65_08555	COG1283	sodium-dependent phosphate transmembrane transporter activity
L3V65_08560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L3V65_08565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L3V65_08570	COG2264	protein methyltransferase activity
L3V65_08580	COG0443	Heat shock 70 kDa protein
L3V65_08585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L3V65_08595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L3V65_08600	COG0481	GTPase activity
L3V65_08605	COG0860	N-Acetylmuramoyl-L-alanine amidase
L3V65_08610	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
L3V65_08615	COG0268	Binds directly to 16S ribosomal RNA
L3V65_08620	COG1466	dna polymerase III delta subunit
L3V65_08635	COG2131	deaminase
L3V65_08640	COG1596	polysaccharide export
L3V65_08640	COG1555	photosystem II stabilization
L3V65_08645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L3V65_08650	COG2226	methyltransferase
L3V65_08655	COG0799	negative regulation of ribosome biogenesis
L3V65_08660	COG1713	HD superfamily hydrolase involved in NAD metabolism
L3V65_08665	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L3V65_08670	COG1534	Rna-binding protein
L3V65_08680	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L3V65_08685	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
L3V65_08690	COG0247	lactate metabolic process
L3V65_08695	COG0277	FAD linked oxidase domain protein
L3V65_08700	COG3835	regulator
L3V65_08705	COG2132	Multicopper oxidase
L3V65_08710	COG0071	Belongs to the small heat shock protein (HSP20) family
L3V65_08720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L3V65_08730	COG1704	LemA family
L3V65_08760	COG1183	phosphatidylcholine synthase activity
L3V65_08770	COG3634	alkyl hydroperoxide reductase activity
L3V65_08775	COG0450	alkyl hydroperoxide reductase
L3V65_08805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L3V65_08810	COG0572	uridine kinase
L3V65_08815	COG4122	O-methyltransferase activity
L3V65_08820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L3V65_08825	COG3906	Belongs to the UPF0473 family
L3V65_08830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L3V65_08835	COG4472	Bacterial protein of unknown function (DUF965)
L3V65_08840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L3V65_08845	COG0628	permease
L3V65_08865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L3V65_08870	COG0457	Tetratricopeptide repeat
L3V65_08870	COG1477	protein flavinylation
L3V65_08875	COG0482	sulfurtransferase activity
L3V65_08880	COG1104	cysteine desulfurase activity
L3V65_08885	COG1959	2 iron, 2 sulfur cluster binding
L3V65_08890	COG1028	Short-chain dehydrogenase reductase Sdr
L3V65_08895	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L3V65_08900	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L3V65_08905	COG0385	Bile acid
L3V65_08915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L3V65_08920	COG0124	histidyl-tRNA synthetase
L3V65_08930	COG0860	N-Acetylmuramoyl-L-alanine amidase
L3V65_08930	COG3103	Sh3 type 3 domain protein
L3V65_08930	COG4991	sh3 domain protein
L3V65_08935	COG2814	Major facilitator Superfamily
L3V65_08940	COG1566	PFAM secretion protein HlyD family protein
L3V65_08945	COG1846	Transcriptional regulator
L3V65_08950	COG1490	D-aminoacyl-tRNA deacylase activity
L3V65_08955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L3V65_08960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L3V65_08965	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L3V65_08965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L3V65_08970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L3V65_08970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L3V65_08980	COG2244	polysaccharide biosynthetic process
L3V65_08985	COG2323	membrane
L3V65_08995	COG1862	Preprotein translocase
L3V65_09000	COG0343	queuine tRNA-ribosyltransferase activity
L3V65_09005	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L3V65_09020	COG0632	four-way junction helicase activity
L3V65_09025	COG0217	transcriptional regulatory protein
L3V65_09035	COG1388	LysM domain
L3V65_09040	COG1827	regulation of RNA biosynthetic process
L3V65_09045	COG0077	Prephenate dehydratase
L3V65_09050	COG4492	Belongs to the UPF0735 family
L3V65_09055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L3V65_09060	COG3290	protein histidine kinase activity
L3V65_09065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L3V65_09070	COG2868	ribosomal protein
L3V65_09075	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L3V65_09080	COG1530	ribonuclease E activity
L3V65_09085	COG1994	Peptidase M50
L3V65_09095	COG2894	cell division
L3V65_09100	COG0850	regulation of cytokinetic process
L3V65_09110	COG1792	Involved in formation and maintenance of cell shape
L3V65_09115	COG1077	Cell shape determining protein MreB Mrl
L3V65_09120	COG2003	Belongs to the UPF0758 family
L3V65_09130	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L3V65_09155	COG1459	type II secretion system
L3V65_09165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L3V65_09205	COG0285	dihydrofolate synthase activity
L3V65_09210	COG0525	valine-tRNA ligase activity
L3V65_09220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L3V65_09225	COG1388	LysM domain
L3V65_09225	COG1388	LysM domain
L3V65_09230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L3V65_09235	COG0113	porphobilinogen synthase activity
L3V65_09245	COG0181	hydroxymethylbilane synthase activity
L3V65_09250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L3V65_09265	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L3V65_09270	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L3V65_09275	COG0470	DNA polymerase III
L3V65_09275	COG1067	ATP-dependent peptidase activity
L3V65_09285	COG0544	peptidyl-prolyl cis-trans isomerase activity
L3V65_09290	COG0457	Tetratricopeptide repeat
L3V65_09290	COG1477	protein flavinylation
L3V65_09310	COG0622	Phosphoesterase
L3V65_09315	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L3V65_09320	COG5401	PFAM Sporulation and spore germination
L3V65_09330	COG5577	PFAM Coat F domain
L3V65_09345	COG1846	Transcriptional regulator
L3V65_09365	COG2197	response regulator
L3V65_09375	COG0824	Thioesterase
L3V65_09380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L3V65_09385	COG1053	succinate dehydrogenase
L3V65_09390	COG2009	succinate dehydrogenase
L3V65_09400	COG1719	4-vinyl reductase, 4VR
L3V65_09410	COG0322	excinuclease ABC activity
L3V65_09415	COG3118	belongs to the thioredoxin family
L3V65_09420	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L3V65_09425	COG2086	electron transfer activity
L3V65_09430	COG1024	Enoyl-CoA hydratase
L3V65_09435	COG1309	transcriptional regulator
L3V65_09440	COG0318	PFAM AMP-dependent synthetase and ligase
L3V65_09445	COG1193	negative regulation of DNA recombination
L3V65_09450	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L3V65_09450	COG1796	DNA polymerase
L3V65_09455	COG1286	toxin biosynthetic process
L3V65_09460	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
L3V65_09470	COG4978	Transcriptional regulator
L3V65_09470	COG0789	Transcriptional regulator
L3V65_09480	COG0072	phenylalanine-tRNA ligase activity
L3V65_09480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L3V65_09485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L3V65_09490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L3V65_09515	COG1695	Transcriptional regulator
L3V65_09535	COG0431	NADPH-dependent FMN reductase
L3V65_09540	COG1363	Peptidase, m42
L3V65_09555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L3V65_09565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L3V65_09575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L3V65_09585	COG1484	DNA-dependent DNA replication
L3V65_09590	COG3611	Membrane attachment protein
L3V65_09595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L3V65_09605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L3V65_09610	COG0237	dephospho-CoA kinase activity
L3V65_09615	COG1971	Probably functions as a manganese efflux pump
L3V65_09620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L3V65_09625	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L3V65_09625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L3V65_09630	COG0039	L-malate dehydrogenase activity
L3V65_09635	COG0538	isocitrate dehydrogenase activity
L3V65_09640	COG0372	Belongs to the citrate synthase family
L3V65_09645	COG2707	UPF0756 membrane protein
L3V65_09650	COG0628	permease
L3V65_09660	COG0205	6-phosphofructokinase activity
L3V65_09665	COG0825	malonyl-CoA metabolic process
L3V65_09670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L3V65_09675	COG0281	malic enzyme
L3V65_09680	COG0587	DNA-directed DNA polymerase activity
L3V65_09695	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L3V65_09705	COG4109	DRTGG domain
L3V65_09710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L3V65_09715	COG0006	proline dipeptidase activity
L3V65_09730	COG0589	response to stress
L3V65_09740	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L3V65_09745	COG0827	DNA restriction-modification system
L3V65_09750	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L3V65_09755	COG3874	Sporulation protein YtfJ
L3V65_09765	COG1714	RDD family
L3V65_09770	COG0616	signal peptide processing
L3V65_09775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L3V65_09785	COG0301	tRNA thio-modification
L3V65_09790	COG1104	cysteine desulfurase activity
L3V65_09795	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
L3V65_09800	COG1309	transcriptional regulator
L3V65_09805	COG1956	GAF domain-containing protein
L3V65_09810	COG2199	diguanylate cyclase activity
L3V65_09810	COG2203	Gaf domain
L3V65_09815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L3V65_09830	COG0506	proline dehydrogenase activity
L3V65_09835	COG1012	belongs to the aldehyde dehydrogenase family
L3V65_09840	COG3829	transcription factor binding
L3V65_09840	COG3290	protein histidine kinase activity
L3V65_09865	COG0454	-acetyltransferase
L3V65_09870	COG0517	IMP dehydrogenase activity
L3V65_09875	COG0123	including yeast histone deacetylase and acetoin utilization protein
L3V65_09885	COG1605	Chorismate mutase
L3V65_09885	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
L3V65_09890	COG4980	gas vesicle protein
L3V65_09900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L3V65_09905	COG1674	ftsk spoiiie
L3V65_09920	COG4848	Belongs to the UPF0354 family
L3V65_09925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L3V65_09930	COG2208	phosphoserine phosphatase activity
L3V65_09945	COG5584	Small secreted protein
L3V65_09950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L3V65_09955	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L3V65_09965	COG0510	thiamine kinase activity
L3V65_09990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L3V65_09995	COG1349	DNA-binding transcription factor activity
L3V65_10000	COG2244	polysaccharide biosynthetic process
L3V65_10020	COG0495	leucyl-tRNA aminoacylation
L3V65_10025	COG2814	Major facilitator Superfamily
L3V65_10035	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
L3V65_10045	COG2267	carboxylic ester hydrolase activity
L3V65_10050	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L3V65_10055	COG0367	asparagine synthase
L3V65_10060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L3V65_10085	COG3335	DDE superfamily endonuclease
L3V65_10095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L3V65_10100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L3V65_10105	COG3344	reverse transcriptase
L3V65_10110	COG1472	Belongs to the glycosyl hydrolase 3 family
L3V65_10140	COG1506	peptidase
L3V65_10145	COG0655	NAD(P)H dehydrogenase (quinone) activity
L3V65_10155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L3V65_10160	COG1116	anion transmembrane transporter activity
L3V65_10165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L3V65_10185	COG0783	Belongs to the Dps family
L3V65_10190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L3V65_10200	COG0803	Belongs to the bacterial solute-binding protein 9 family
L3V65_10210	COG4948	Mandelate Racemase Muconate Lactonizing
L3V65_10215	COG0318	PFAM AMP-dependent synthetase and ligase
L3V65_10220	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L3V65_10225	COG0596	Alpha beta hydrolase
L3V65_10230	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
L3V65_10235	COG1169	isochorismate synthase
L3V65_10240	COG1575	Belongs to the MenA family. Type 1 subfamily
L3V65_10370	COG1285	pathogenesis
L3V65_10385	COG2217	Heavy metal translocating P-type atpase
L3V65_10390	COG2608	mercury ion transmembrane transporter activity
L3V65_10405	COG1522	sequence-specific DNA binding
L3V65_10425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L3V65_10445	COG0726	polysaccharide deacetylase
L3V65_10465	COG0038	chloride channel
L3V65_10475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L3V65_10480	COG1937	Protein conserved in bacteria
L3V65_10485	COG1525	nuclease
L3V65_10490	COG2190	(PTS) system
L3V65_10495	COG2160	L-arabinose isomerase activity
L3V65_10515	COG1609	Transcriptional regulator
L3V65_10520	COG0840	transmembrane signaling receptor activity
L3V65_10540	COG1028	Short-chain dehydrogenase reductase Sdr
L3V65_10545	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
L3V65_10560	COG1012	belongs to the aldehyde dehydrogenase family
L3V65_10580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L3V65_10590	COG2155	Conserved Protein
L3V65_10600	COG1098	S1 RNA binding domain
L3V65_10610	COG1902	pentaerythritol trinitrate reductase activity
L3V65_10615	COG0656	L-ascorbic acid biosynthetic process
L3V65_10635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L3V65_10645	COG2814	Major facilitator Superfamily
L3V65_10650	COG2050	protein possibly involved in aromatic compounds catabolism
L3V65_10665	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L3V65_10675	COG0697	spore germination
L3V65_10685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L3V65_10690	COG3584	3D domain protein
L3V65_10700	COG1252	NADH dehydrogenase
L3V65_10705	COG0492	ferredoxin-NADP+ reductase activity
L3V65_10735	COG0316	Belongs to the HesB IscA family
L3V65_10740	COG4837	Protein of unknown function (DUF1462)
L3V65_10745	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L3V65_10750	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L3V65_10755	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L3V65_10760	COG0647	UMP catabolic process
L3V65_10765	COG2445	Protein of unknown function DUF86
L3V65_10770	COG4470	Protein conserved in bacteria
L3V65_10775	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L3V65_10780	COG0739	heme binding
L3V65_10790	COG3377	Domain of unknown function (DUF1805)
L3V65_10795	COG0737	Belongs to the 5'-nucleotidase family
L3V65_10800	COG0719	Fe-S assembly protein
L3V65_10805	COG0822	iron-sulfur transferase activity
L3V65_10810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L3V65_10815	COG0719	Fe-S assembly protein
L3V65_10820	COG0396	ATPase activity
L3V65_10830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L3V65_10835	COG0509	glycine decarboxylation via glycine cleavage system
L3V65_10840	COG1393	Belongs to the ArsC family
L3V65_10845	COG1960	acyl-CoA dehydrogenase activity
L3V65_10850	COG0183	Belongs to the thiolase family
L3V65_10855	COG1250	3-hydroxyacyl-CoA dehydrogenase
L3V65_10855	COG1024	Enoyl-CoA hydratase
L3V65_10870	COG5577	PFAM Coat F domain
L3V65_10875	COG0772	Belongs to the SEDS family
L3V65_10880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L3V65_10895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L3V65_10905	COG0753	catalase activity
L3V65_10910	COG0671	phosphoesterase, PA-phosphatase related
L3V65_10920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L3V65_10935	COG1595	DNA-templated transcription, initiation
L3V65_10940	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L3V65_10980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L3V65_10985	COG0557	exoribonuclease II activity
L3V65_10995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L3V65_11000	COG0148	phosphopyruvate hydratase activity
L3V65_11005	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L3V65_11015	COG0126	phosphoglycerate kinase activity
L3V65_11035	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L3V65_11050	COG3383	formate dehydrogenase (NAD+) activity
L3V65_11065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L3V65_11080	COG4608	Belongs to the ABC transporter superfamily
L3V65_11085	COG0791	NLP P60 protein
L3V65_11090	COG4166	transmembrane transport
L3V65_11095	COG0444	Belongs to the ABC transporter superfamily
L3V65_11100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3V65_11105	COG0601	transmembrane transport
L3V65_11110	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L3V65_11115	COG0598	Magnesium transport protein CorA
L3V65_11125	COG2719	SpoVR family
L3V65_11130	COG3594	Acyltransferase
L3V65_11155	COG1392	Phosphate transport regulator
L3V65_11160	COG0306	phosphate transporter
L3V65_11175	COG2718	Belongs to the UPF0229 family
L3V65_11180	COG2766	serine protein kinase
L3V65_11185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L3V65_11200	COG2095	MarC family integral membrane protein
L3V65_11210	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
L3V65_11215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3V65_11220	COG0765	amino acid transport
L3V65_11225	COG1126	abc transporter atp-binding protein
L3V65_11230	COG2116	formate transmembrane transporter activity
L3V65_11245	COG1882	Formate acetyltransferase
L3V65_11250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L3V65_11255	COG0431	NADPH-dependent FMN reductase
L3V65_11270	COG1131	(ABC) transporter
L3V65_11345	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L3V65_11350	COG2188	Transcriptional regulator
L3V65_11365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L3V65_11380	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L3V65_11395	COG0640	Transcriptional regulator
L3V65_11400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L3V65_11405	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L3V65_11410	COG0640	Transcriptional regulator
L3V65_11420	COG3850	Histidine kinase
L3V65_11420	COG5002	protein histidine kinase activity
L3V65_11425	COG0745	RESPONSE REGULATOR receiver
L3V65_11430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L3V65_11435	COG2022	thiamine diphosphate biosynthetic process
L3V65_11445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L3V65_11450	COG0352	thiamine-phosphate diphosphorylase activity
L3V65_11460	COG2271	Major facilitator Superfamily
L3V65_11480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3V65_11485	COG2323	membrane
L3V65_11590	COG3527	Alpha-acetolactate decarboxylase
L3V65_11595	COG0028	Belongs to the TPP enzyme family
L3V65_11600	COG0583	DNA-binding transcription factor activity
L3V65_11605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L3V65_11610	COG0735	belongs to the Fur family
L3V65_11625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L3V65_11635	COG4129	membrane
L3V65_11640	COG1737	Transcriptional regulator
L3V65_11645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3V65_11645	COG1263	PTS System
L3V65_11650	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
L3V65_11660	COG1132	(ABC) transporter
L3V65_11665	COG3557	Belongs to the UPF0374 family
L3V65_11680	COG1028	Short-chain dehydrogenase reductase Sdr
L3V65_11685	COG0583	DNA-binding transcription factor activity
L3V65_11690	COG0069	glutamate synthase activity
L3V65_11690	COG0070	glutamate synthase
L3V65_11690	COG0067	glutamate synthase
L3V65_11695	COG0493	'glutamate synthase
L3V65_11720	COG1988	membrane-bound metal-dependent
L3V65_11725	COG1194	a g-specific adenine glycosylase
L3V65_11735	COG2137	regulation of response to DNA damage stimulus
L3V65_11750	COG0159	tryptophan synthase activity
L3V65_11765	COG0134	indole-3-glycerol-phosphate synthase activity
L3V65_11770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L3V65_11775	COG0512	Glutamine amidotransferase of anthranilate synthase
L3V65_11775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L3V65_11785	COG0577	efflux transmembrane transporter activity
L3V65_11790	COG0577	efflux transmembrane transporter activity
L3V65_11790	COG1136	(ABC) transporter
L3V65_11870	COG1136	(ABC) transporter
L3V65_11870	COG0577	efflux transmembrane transporter activity
L3V65_11875	COG0058	SHG alpha-glucan phosphorylase activity
L3V65_11880	COG0840	transmembrane signaling receptor activity
L3V65_11885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L3V65_11890	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L3V65_11895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L3V65_11910	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L3V65_11915	COG0066	3-isopropylmalate dehydratase activity
L3V65_11920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L3V65_11930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L3V65_11935	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L3V65_11940	COG0440	acetolactate synthase activity
L3V65_11945	COG0028	Belongs to the TPP enzyme family
L3V65_11955	COG1114	Component of the transport system for branched-chain amino acids
L3V65_11960	COG1366	Belongs to the anti-sigma-factor antagonist family
L3V65_11970	COG2124	cytochrome p450
L3V65_11975	COG0670	Belongs to the BI1 family
L3V65_11980	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L3V65_11985	COG2223	nitrite transmembrane transporter activity
L3V65_11990	COG3279	Response regulator of the LytR AlgR family
L3V65_11995	COG3275	phosphorelay sensor kinase activity
L3V65_12005	COG2132	Multicopper oxidase
L3V65_12010	COG2132	Multicopper oxidase
L3V65_12015	COG1309	transcriptional regulator
L3V65_12020	COG1511	domain protein
L3V65_12050	COG3739	integral membrane protein
L3V65_12055	COG3655	Transcriptional regulator
L3V65_12070	COG1823	symporter activity
L3V65_12075	COG2839	Protein conserved in bacteria
L3V65_12095	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
L3V65_12100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L3V65_12110	COG1132	(ABC) transporter
L3V65_12115	COG1846	Transcriptional regulator
L3V65_12120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L3V65_12125	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
L3V65_12150	COG0387	Pfam Sodium calcium exchanger
L3V65_12155	COG0477	Major facilitator Superfamily
L3V65_12160	COG1295	ribonuclease BN
L3V65_12165	COG4840	Belongs to the UPF0435 family
L3V65_12170	COG0024	Methionine aminopeptidase
L3V65_12175	COG0693	protein deglycase activity
L3V65_12180	COG1360	Flagellar Motor Protein
L3V65_12185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L3V65_12200	COG3189	MarR family transcriptional regulator
L3V65_12210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L3V65_12215	COG1607	acyl-coa hydrolase
L3V65_12220	COG1077	Cell shape determining protein MreB Mrl
L3V65_12225	COG2268	Band 7 protein
L3V65_12230	COG1585	Membrane protein implicated in regulation of membrane protease activity
L3V65_12235	COG0626	cystathionine gamma-synthase activity
L3V65_12240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L3V65_12245	COG1854	S-ribosylhomocysteine lyase activity
L3V65_12250	COG2226	methyltransferase
L3V65_12255	COG0288	reversible hydration of carbon dioxide
L3V65_12260	COG0860	N-Acetylmuramoyl-L-alanine amidase
L3V65_12270	COG2197	response regulator
L3V65_12295	COG4086	secreted protein
L3V65_12300	COG1737	Transcriptional regulator
L3V65_12305	COG0737	Belongs to the 5'-nucleotidase family
L3V65_12320	COG3620	sequence-specific DNA binding
L3V65_12335	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
L3V65_12340	COG1518	maintenance of DNA repeat elements
L3V65_12385	COG1304	FMN binding
L3V65_12390	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
L3V65_12395	COG0166	Belongs to the GPI family
L3V65_12400	COG0025	NhaP-type Na H and K H
L3V65_12410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L3V65_12410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L3V65_12410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3V65_12415	COG1349	DNA-binding transcription factor activity
L3V65_12420	COG0371	Dehydrogenase
L3V65_12425	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
L3V65_12435	COG0561	phosphatase activity
L3V65_12455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L3V65_12475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L3V65_12480	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
L3V65_12485	COG1461	Dihydroxyacetone kinase
L3V65_12490	COG2376	Dihydroxyacetone kinase
L3V65_12500	COG0778	Nitroreductase
L3V65_12505	COG1113	amino acid transport
L3V65_12510	COG0730	response to heat
L3V65_12515	COG2233	PERMEase
L3V65_12520	COG0210	DNA helicase
L3V65_12525	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L3V65_12550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L3V65_12555	COG3829	transcription factor binding
L3V65_12560	COG0732	type I restriction modification DNA specificity domain
L3V65_12575	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
L3V65_12580	COG0833	amino acid
L3V65_12605	COG3588	fructose-bisphosphate aldolase
L3V65_12615	COG1280	lysine exporter protein (LysE YggA)
L3V65_12620	COG0386	Belongs to the glutathione peroxidase family
L3V65_12625	COG2190	(PTS) system
L3V65_12640	COG3403	YqcI/YcgG family
L3V65_12650	COG0582	viral genome integration into host DNA
L3V65_12685	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L3V65_12700	COG1301	dicarboxylic acid transport
L3V65_12715	COG1328	CTP reductase activity
L3V65_12725	COG1063	alcohol dehydrogenase
L3V65_12730	COG1929	Belongs to the glycerate kinase type-1 family
L3V65_12745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L3V65_12750	COG0436	Aminotransferase
L3V65_12765	COG4549	nuclear export factor GLE1
L3V65_12770	COG1276	copper resistance
L3V65_12770	COG2372	response to copper ion
L3V65_12780	COG5002	protein histidine kinase activity
L3V65_12790	COG1278	Cold shock
L3V65_12825	COG3876	Protein conserved in bacteria
L3V65_12830	COG1132	(ABC) transporter
L3V65_12835	COG1132	(ABC) transporter
L3V65_12845	COG1349	DNA-binding transcription factor activity
L3V65_12850	COG1082	Xylose isomerase domain protein TIM barrel
L3V65_12855	COG1082	Xylose isomerase domain protein TIM barrel
L3V65_12860	COG0673	inositol 2-dehydrogenase activity
L3V65_12865	COG2814	Major facilitator Superfamily
L3V65_12870	COG1082	Xylose isomerase domain protein TIM barrel
L3V65_12890	COG1082	Xylose isomerase domain protein TIM barrel
L3V65_12910	COG2814	Major facilitator Superfamily
L3V65_12915	COG0191	fructose-bisphosphate aldolase activity
L3V65_12920	COG3962	Belongs to the TPP enzyme family
L3V65_12925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L3V65_12930	COG3718	enzyme involved in inositol metabolism
L3V65_12935	COG1012	belongs to the aldehyde dehydrogenase family
L3V65_12940	COG1388	LysM domain
L3V65_12940	COG0791	NLP P60 protein
L3V65_12975	COG3153	acetyltransferase
L3V65_12975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L3V65_12995	COG0516	GMP reductase activity
L3V65_13000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L3V65_13010	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L3V65_13015	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L3V65_13035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L3V65_13045	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
L3V65_13060	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
L3V65_13065	COG1984	allophanate hydrolase subunit 2
L3V65_13070	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L3V65_13085	COG2814	Major facilitator Superfamily
L3V65_13090	COG1764	response to oxidative stress
L3V65_13095	COG1126	abc transporter atp-binding protein
L3V65_13100	COG0765	amino acid transport
L3V65_13105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3V65_13110	COG1473	amidohydrolase
L3V65_13115	COG0326	Molecular chaperone. Has ATPase activity
L3V65_13140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L3V65_13150	COG1064	alcohol dehydrogenase
L3V65_13170	COG5444	nuclease activity
L3V65_13215	COG3561	AntA/AntB antirepressor
L3V65_13230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L3V65_13230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L3V65_13270	COG0662	Cupin 2, conserved barrel domain protein
L3V65_13320	COG4372	Transposase
L3V65_13330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L3V65_13335	COG1597	lipid kinase activity
L3V65_13360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L3V65_13365	COG0154	amidase activity
L3V65_13370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L3V65_13375	COG2224	Isocitrate lyase
L3V65_13380	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L3V65_13385	COG4851	CamS sex pheromone cAM373 precursor
L3V65_13395	COG0210	DNA helicase
L3V65_13400	COG3344	reverse transcriptase
L3V65_13410	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
L3V65_13415	COG4496	protein, YerC YecD
L3V65_13420	COG1470	cell adhesion involved in biofilm formation
L3V65_13435	COG0151	Belongs to the GarS family
L3V65_13440	COG0138	bifunctional purine biosynthesis protein purh
L3V65_13445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L3V65_13450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L3V65_13455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L3V65_13460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L3V65_13465	COG0047	phosphoribosylformylglycinamidine synthase activity
L3V65_13470	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L3V65_13480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L3V65_13485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L3V65_13490	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L3V65_13500	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
L3V65_13505	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L3V65_13510	COG2190	(PTS) system
L3V65_13510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3V65_13510	COG1263	PTS System
L3V65_13535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L3V65_13535	COG1263	PTS System
L3V65_13560	COG1301	dicarboxylic acid transport
L3V65_13570	COG3711	transcriptional antiterminator
L3V65_13575	COG2252	PERMEase
L3V65_13590	COG2814	Major facilitator Superfamily
L3V65_13610	COG0471	metal ion transport
L3V65_13635	COG1131	(ABC) transporter
L3V65_13640	COG1725	Transcriptional regulator
L3V65_13675	COG0425	Belongs to the sulfur carrier protein TusA family
L3V65_13680	COG2391	methyltransferase activity
L3V65_13690	COG1028	Short-chain dehydrogenase reductase Sdr
L3V65_13710	COG1120	ATPase activity
L3V65_13715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3V65_13740	COG1404	Belongs to the peptidase S8 family
L3V65_13765	COG3620	sequence-specific DNA binding
L3V65_13780	COG0519	Catalyzes the synthesis of GMP from XMP
L3V65_13780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L3V65_13785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L3V65_13790	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L3V65_13795	COG1335	isochorismatase
L3V65_13800	COG4948	Mandelate Racemase Muconate Lactonizing
L3V65_13810	COG0463	Glycosyl transferase, family 2
L3V65_13815	COG2246	polysaccharide biosynthetic process
L3V65_13820	COG0459	protein refolding
L3V65_13825	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L3V65_13830	COG1266	CAAX protease self-immunity
L3V65_13840	COG0805	protein transport
L3V65_13845	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
L3V65_13850	COG0488	(ABC) transporter
L3V65_13855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L3V65_13860	COG0456	acetyltransferase
L3V65_13865	COG1214	PFAM Peptidase M22, glycoprotease
L3V65_13870	COG0802	atpase or kinase
L3V65_13960	COG3091	SprT-like family
L3V65_13970	COG2183	response to ionizing radiation
L3V65_13975	COG2208	phosphoserine phosphatase activity
L3V65_13985	COG2172	sigma factor antagonist activity
L3V65_13990	COG1366	Belongs to the anti-sigma-factor antagonist family
L3V65_13995	COG2208	phosphoserine phosphatase activity
L3V65_14000	COG2172	sigma factor antagonist activity
L3V65_14005	COG1366	Belongs to the anti-sigma-factor antagonist family
L3V65_14010	COG1366	Belongs to the anti-sigma-factor antagonist family
L3V65_14015	COG2337	Toxic component of a toxin-antitoxin (TA) module
L3V65_14020	COG0864	Transcriptional regulator
L3V65_14025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L3V65_14030	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L3V65_14035	COG0736	holo-[acyl-carrier-protein] synthase activity
L3V65_14040	COG0705	Rhomboid family
L3V65_14045	COG0513	Belongs to the DEAD box helicase family
L3V65_14050	COG1280	lysine exporter protein (LysE YggA)
L3V65_14055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L3V65_14060	COG1609	Transcriptional regulator
L3V65_14065	COG0366	Alpha amylase catalytic
L3V65_14075	COG2182	Extracellular solute-binding protein
L3V65_14080	COG1175	transmembrane transport
L3V65_14085	COG3833	ABC-type maltose transport systems, permease component
L3V65_14090	COG5521	maltodextrose utilization protein MalA
L3V65_14095	COG1554	hydrolase, family 65, central catalytic
L3V65_14105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L3V65_14110	COG1181	Belongs to the D-alanine--D-alanine ligase family
L3V65_14120	COG1253	flavin adenine dinucleotide binding
L3V65_14125	COG0789	Transcriptional regulator
L3V65_14130	COG1253	flavin adenine dinucleotide binding
L3V65_14140	COG4715	Zinc finger, swim domain protein
L3V65_14145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L3V65_14160	COG0629	single-stranded DNA binding
L3V65_14170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L3V65_14175	COG4786	Flagellar basal body rod
L3V65_14180	COG4786	Flagellar basal body rod
L3V65_14190	COG1609	Transcriptional regulator
L3V65_14195	COG0739	heme binding
L3V65_14200	COG2385	sporulation resulting in formation of a cellular spore
L3V65_14205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L3V65_14215	COG4836	Membrane
L3V65_14220	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L3V65_14225	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L3V65_14230	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L3V65_14235	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L3V65_14240	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L3V65_14250	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L3V65_14255	COG0356	it plays a direct role in the translocation of protons across the membrane
L3V65_14265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L3V65_14270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L3V65_14275	COG4475	Protein of unknown function (DUF436)
L3V65_14280	COG0698	ribose 5-phosphate isomerase
L3V65_14285	COG0840	transmembrane signaling receptor activity
L3V65_14320	COG1971	Probably functions as a manganese efflux pump
L3V65_14325	COG0009	L-threonylcarbamoyladenylate synthase
L3V65_14340	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L3V65_14350	COG1435	thymidine kinase activity
L3V65_14355	COG0254	rRNA binding
L3V65_14360	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L3V65_14365	COG1494	fructose-1,6-bisphosphatase
L3V65_14370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L3V65_14375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L3V65_14380	COG0191	fructose-bisphosphate aldolase activity
L3V65_14385	COG2204	response regulator
L3V65_14400	COG1131	(ABC) transporter
L3V65_14405	COG1725	Transcriptional regulator
L3V65_14410	COG0504	CTP synthase activity
L3V65_14415	COG3343	RNA polymerase activity
L3V65_14430	COG1136	(ABC) transporter
L3V65_14460	COG1309	transcriptional regulator
L3V65_14465	COG1960	acyl-CoA dehydrogenase activity
L3V65_14470	COG1960	acyl-CoA dehydrogenase activity
L3V65_14475	COG0183	Belongs to the thiolase family
L3V65_14480	COG2181	nitrate reductase activity
L3V65_14480	COG0247	lactate metabolic process
L3V65_14485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L3V65_14490	COG0018	arginyl-trna synthetase
L3V65_14500	COG0010	Belongs to the arginase family
L3V65_14505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L3V65_14515	COG1994	Peptidase M50
L3V65_14525	COG3465	dGTPase activity
L3V65_14530	COG1078	dGTPase activity
L3V65_14540	COG0095	Lipoate-protein ligase
L3V65_14550	COG0280	phosphate acetyltransferase
L3V65_14555	COG3253	May function as heme-dependent peroxidase
L3V65_14570	COG2363	Small membrane protein
L3V65_14580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L3V65_14610	COG4555	ABC transporter
L3V65_14615	COG0351	phosphomethylpyrimidine kinase
L3V65_14630	COG0561	phosphatase activity
L3V65_14635	COG0514	ATP-dependent DNA helicase (RecQ)
L3V65_14640	COG1785	Belongs to the alkaline phosphatase family
L3V65_14645	COG1737	Transcriptional regulator
L3V65_14660	COG5002	protein histidine kinase activity
L3V65_14670	COG0745	RESPONSE REGULATOR receiver
L3V65_14680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L3V65_14690	COG1346	cytolysis
L3V65_14695	COG1380	Effector of murein hydrolase LrgA
L3V65_14700	COG0583	DNA-binding transcription factor activity
L3V65_14705	COG0367	asparagine synthase
L3V65_14765	COG2966	Psort location CytoplasmicMembrane, score
L3V65_14770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L3V65_14775	COG1966	Carbon starvation protein
L3V65_14780	COG1464	Belongs to the NlpA lipoprotein family
L3V65_14785	COG2011	ABC-type metal ion transport system permease component
L3V65_14790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L3V65_14795	COG1119	ATPase activity
L3V65_14810	COG0534	Mate efflux family protein
L3V65_14815	COG1442	glycosyl transferase family 8
L3V65_14820	COG2195	Cleaves the N-terminal amino acid of tripeptides
L3V65_14840	COG1404	Belongs to the peptidase S8 family
L3V65_14860	COG0028	Belongs to the TPP enzyme family
L3V65_14875	COG0840	transmembrane signaling receptor activity
L3V65_14885	COG1132	(ABC) transporter
L3V65_14895	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L3V65_14915	COG1366	Belongs to the anti-sigma-factor antagonist family
L3V65_14955	COG0765	amino acid transport
L3V65_14960	COG0579	oxidoreductase
L3V65_14970	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L3V65_14975	COG0732	type I restriction modification DNA specificity domain
L3V65_14980	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L3V65_14995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L3V65_15000	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L3V65_15005	COG4863	YycH protein
L3V65_15010	COG5002	protein histidine kinase activity
L3V65_15015	COG0745	RESPONSE REGULATOR receiver
L3V65_15030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L3V65_15035	COG0305	Participates in initiation and elongation during chromosome replication
L3V65_15040	COG0359	binds to the 23S rRNA
L3V65_15045	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
L3V65_15055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L3V65_15065	COG0360	Binds together with S18 to 16S ribosomal RNA
L3V65_15070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L3V65_15075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L3V65_15075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L3V65_15080	COG0307	riboflavin synthase, alpha
L3V65_15085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L3V65_15085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L3V65_15090	COG0012	GTP binding
L3V65_15095	COG4481	Protein conserved in bacteria
L3V65_15100	COG0668	transmembrane transport
L3V65_15110	COG1811	Na channel or pump
L3V65_15115	COG1475	DNA binding
L3V65_15120	COG1192	Involved in chromosome partitioning
L3V65_15125	COG1475	DNA binding
L3V65_15130	COG0357	Ribosomal RNA small subunit methyltransferase G
L3V65_15135	COG0445	tRNA wobble uridine modification
L3V65_15140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L3V65_15145	COG1847	R3H domain protein
L3V65_15150	COG0706	membrane insertase activity
L3V65_15155	COG0594	ribonuclease P activity
L3V65_15160	COG0230	Belongs to the bacterial ribosomal protein bL34 family