locus-tag	class	description
BIZ35_00010	COG2079	MmgE PrpD family protein
BIZ35_00015	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BIZ35_00025	COG0154	amidase activity
BIZ35_00035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIZ35_00040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIZ35_00045	COG1116	anion transmembrane transporter activity
BIZ35_00050	COG0083	homoserine kinase activity
BIZ35_00055	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BIZ35_00060	COG0460	homoserine dehydrogenase
BIZ35_00065	COG0010	Belongs to the arginase family
BIZ35_00075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BIZ35_00080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BIZ35_00090	COG4145	pantothenate transmembrane transporter activity
BIZ35_00125	COG0791	NLP P60 protein
BIZ35_00125	COG1388	LysM domain
BIZ35_00130	COG0024	Methionine aminopeptidase
BIZ35_00135	COG1268	BioY protein
BIZ35_00150	COG1960	acyl-CoA dehydrogenase activity
BIZ35_00155	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_00160	COG2746	aminoglycoside 3-N-acetyltransferase activity
BIZ35_00165	COG2244	polysaccharide biosynthetic process
BIZ35_00170	COG0589	response to stress
BIZ35_00185	COG0535	radical SAM domain protein
BIZ35_00195	COG0457	Tetratricopeptide repeat
BIZ35_00215	COG1609	Transcriptional regulator
BIZ35_00225	COG0561	phosphatase activity
BIZ35_00260	COG0656	L-ascorbic acid biosynthetic process
BIZ35_00265	COG0431	NADPH-dependent FMN reductase
BIZ35_00270	COG0420	3'-5' exonuclease activity
BIZ35_00275	COG4717	serine-type aminopeptidase activity
BIZ35_00280	COG1250	3-hydroxyacyl-CoA dehydrogenase
BIZ35_00285	COG0534	Mate efflux family protein
BIZ35_00300	COG1664	Polymer-forming cytoskeletal
BIZ35_00310	COG0789	Transcriptional regulator
BIZ35_00315	COG0436	Aminotransferase
BIZ35_00320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BIZ35_00340	COG2226	methyltransferase
BIZ35_00355	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BIZ35_00390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BIZ35_00395	COG1113	amino acid transport
BIZ35_00400	COG2814	Major facilitator Superfamily
BIZ35_00415	COG1033	growth of symbiont in host cell
BIZ35_00415	COG2409	Drug exporters of the RND superfamily
BIZ35_00425	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BIZ35_00440	COG1960	acyl-CoA dehydrogenase activity
BIZ35_00455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BIZ35_00460	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BIZ35_00475	COG1609	Transcriptional regulator
BIZ35_00490	COG2996	Protein conserved in bacteria
BIZ35_00495	COG0346	lactoylglutathione lyase activity
BIZ35_00500	COG1482	cell wall glycoprotein biosynthetic process
BIZ35_00510	COG0477	Major facilitator Superfamily
BIZ35_00515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BIZ35_00525	COG2188	Transcriptional regulator
BIZ35_00530	COG1388	LysM domain
BIZ35_00530	COG0791	NLP P60 protein
BIZ35_00540	COG0768	penicillin binding
BIZ35_00545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BIZ35_00550	COG1739	Uncharacterized protein family UPF0029
BIZ35_00560	COG2197	response regulator
BIZ35_00570	COG0531	amino acid
BIZ35_00575	COG1307	EDD domain protein, DegV family
BIZ35_00580	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BIZ35_00585	COG1040	competence protein
BIZ35_00595	COG2747	anti-sigma28 factor FlgM
BIZ35_00605	COG1256	bacterial-type flagellum assembly
BIZ35_00605	COG4786	Flagellar basal body rod
BIZ35_00610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BIZ35_00620	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BIZ35_00640	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BIZ35_00645	COG1285	pathogenesis
BIZ35_00650	COG0647	UMP catabolic process
BIZ35_00660	COG2271	Major facilitator Superfamily
BIZ35_00675	COG1113	amino acid transport
BIZ35_00690	COG1067	ATP-dependent peptidase activity
BIZ35_00700	COG2094	Belongs to the DNA glycosylase MPG family
BIZ35_00715	COG1334	flagellar protein FlaG
BIZ35_00720	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BIZ35_00725	COG1516	flagellar protein fliS
BIZ35_00745	COG0653	protein targeting
BIZ35_00750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BIZ35_00755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIZ35_00765	COG2884	Cell division ATP-binding protein ftsE
BIZ35_00770	COG2177	Part of the ABC transporter FtsEX involved in
BIZ35_00775	COG0739	heme binding
BIZ35_00790	COG0460	homoserine dehydrogenase
BIZ35_00795	COG0793	Belongs to the peptidase S41A family
BIZ35_00795	COG3409	Peptidoglycan-binding domain 1 protein
BIZ35_00805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIZ35_00810	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIZ35_00815	COG4605	iron ion homeostasis
BIZ35_00820	COG4604	ABC transporter, ATP-binding protein
BIZ35_00825	COG4607	ABC-type enterochelin transport system periplasmic component
BIZ35_00840	COG0745	RESPONSE REGULATOR receiver
BIZ35_00845	COG5002	protein histidine kinase activity
BIZ35_00850	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BIZ35_00865	COG0573	inorganic phosphate transmembrane transporter activity
BIZ35_00870	COG0581	inorganic phosphate transmembrane transporter activity
BIZ35_00880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BIZ35_00925	COG0556	nucleotide-excision repair
BIZ35_00930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BIZ35_00935	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BIZ35_00945	COG0463	Glycosyl transferase, family 2
BIZ35_00955	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BIZ35_00960	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BIZ35_00960	COG0463	Glycosyl transferase, family 2
BIZ35_00965	COG1682	transport, permease protein
BIZ35_00970	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BIZ35_00975	COG3595	metallopeptidase activity
BIZ35_00985	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BIZ35_00990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BIZ35_00995	COG0546	phosphoglycolate phosphatase activity
BIZ35_01000	COG0110	maltose O-acetyltransferase activity
BIZ35_01005	COG0457	Tetratricopeptide repeat
BIZ35_01010	COG0492	ferredoxin-NADP+ reductase activity
BIZ35_01020	COG1051	belongs to the nudix hydrolase family
BIZ35_01025	COG1660	Displays ATPase and GTPase activities
BIZ35_01030	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BIZ35_01035	COG1481	regulation of sporulation
BIZ35_01040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_01075	COG3842	ATPase activity
BIZ35_01080	COG2508	Transcriptional regulator
BIZ35_01090	COG0189	ligase activity
BIZ35_01095	COG0189	ligase activity
BIZ35_01110	COG4399	Belongs to the UPF0754 family
BIZ35_01120	COG0561	phosphatase activity
BIZ35_01125	COG1024	Enoyl-CoA hydratase
BIZ35_01135	COG0861	Integral membrane protein TerC family
BIZ35_01140	COG0701	Predicted permease
BIZ35_01145	COG3689	TIGRFAM TIGR03943 family protein
BIZ35_01150	COG0420	3'-5' exonuclease activity
BIZ35_01155	COG4717	serine-type aminopeptidase activity
BIZ35_01160	COG3481	metal-dependent phosphohydrolase, HD sub domain
BIZ35_01170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BIZ35_01190	COG1846	Transcriptional regulator
BIZ35_01210	COG0537	adenosine 5'-monophosphoramidase activity
BIZ35_01215	COG1131	(ABC) transporter
BIZ35_01220	COG4473	ABC transporter
BIZ35_01225	COG1473	amidohydrolase
BIZ35_01230	COG3069	C4-dicarboxylate transmembrane transporter activity
BIZ35_01235	COG2329	Antibiotic biosynthesis monooxygenase
BIZ35_01240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BIZ35_01245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BIZ35_01250	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BIZ35_01255	COG1309	transcriptional regulator
BIZ35_01260	COG1511	domain protein
BIZ35_01265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_01265	COG1263	PTS System
BIZ35_01265	COG2190	(PTS) system
BIZ35_01265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_01265	COG1263	PTS System
BIZ35_01265	COG2190	(PTS) system
BIZ35_01270	COG1349	DNA-binding transcription factor activity
BIZ35_01280	COG0697	spore germination
BIZ35_01285	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_01290	COG1999	signal sequence binding
BIZ35_01305	COG0095	Lipoate-protein ligase
BIZ35_01310	COG0318	PFAM AMP-dependent synthetase and ligase
BIZ35_01320	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BIZ35_01330	COG0501	Belongs to the peptidase M48B family
BIZ35_01355	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BIZ35_01360	COG1074	ATP-dependent DNA helicase activity
BIZ35_01395	COG2311	Membrane
BIZ35_01400	COG0179	Fumarylacetoacetate (FAA) hydrolase
BIZ35_01415	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_01420	COG1307	EDD domain protein, DegV family
BIZ35_01430	COG0561	phosphatase activity
BIZ35_01435	COG2151	metal-sulfur cluster biosynthetic enzyme
BIZ35_01465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIZ35_01470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BIZ35_01485	COG4608	Belongs to the ABC transporter superfamily
BIZ35_01490	COG0601	transmembrane transport
BIZ35_01500	COG0747	negative chemotaxis
BIZ35_01515	COG0180	Tryptophanyl-tRNA synthetase
BIZ35_01530	COG4166	transmembrane transport
BIZ35_01535	COG0601	transmembrane transport
BIZ35_01540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIZ35_01545	COG0444	Belongs to the ABC transporter superfamily
BIZ35_01550	COG4608	Belongs to the ABC transporter superfamily
BIZ35_01555	COG1393	Belongs to the ArsC family
BIZ35_01565	COG4862	establishment of competence for transformation
BIZ35_01570	COG4469	Competence protein
BIZ35_01575	COG1164	Oligoendopeptidase f
BIZ35_01585	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BIZ35_01590	COG2346	COG2346, Truncated hemoglobins
BIZ35_01595	COG0741	lytic transglycosylase activity
BIZ35_01600	COG4116	CYTH
BIZ35_01610	COG2357	RelA SpoT domain protein
BIZ35_01620	COG0564	pseudouridine synthase activity
BIZ35_01625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BIZ35_01630	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BIZ35_01665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIZ35_01685	COG2153	protein acetylation
BIZ35_01695	COG2382	esterase
BIZ35_01710	COG1940	carbohydrate kinase activity
BIZ35_01720	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_01725	COG4152	abc transporter atp-binding protein
BIZ35_01730	COG1668	transmembrane transport
BIZ35_01745	COG3579	cysteine-type endopeptidase activity
BIZ35_01810	COG1247	-acetyltransferase
BIZ35_01830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BIZ35_01835	COG2059	Chromate
BIZ35_01840	COG2059	Chromate
BIZ35_01845	COG1522	sequence-specific DNA binding
BIZ35_01855	COG0405	Gamma-glutamyltransferase
BIZ35_01860	COG0154	amidase activity
BIZ35_01970	COG4974	Belongs to the 'phage' integrase family
BIZ35_01985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BIZ35_01990	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIZ35_02015	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_02035	COG1959	2 iron, 2 sulfur cluster binding
BIZ35_02050	COG0730	response to heat
BIZ35_02055	COG0783	Belongs to the Dps family
BIZ35_02065	COG0673	inositol 2-dehydrogenase activity
BIZ35_02070	COG3852	Histidine kinase
BIZ35_02075	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BIZ35_02085	COG0861	Integral membrane protein TerC family
BIZ35_02095	COG5002	protein histidine kinase activity
BIZ35_02100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BIZ35_02120	COG0542	response to heat
BIZ35_02125	COG3949	Membrane
BIZ35_02135	COG4873	Protein conserved in bacteria
BIZ35_02150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_02170	COG2084	Dehydrogenase
BIZ35_02175	COG0436	Aminotransferase
BIZ35_02180	COG0835	chemotaxis
BIZ35_02180	COG0784	Response regulator, receiver
BIZ35_02190	COG2409	Drug exporters of the RND superfamily
BIZ35_02190	COG1033	growth of symbiont in host cell
BIZ35_02210	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_02220	COG4703	Protein of unknown function (DUF1797)
BIZ35_02225	COG0517	IMP dehydrogenase activity
BIZ35_02230	COG0583	DNA-binding transcription factor activity
BIZ35_02235	COG2171	N-acyltransferase activity
BIZ35_02240	COG1473	amidohydrolase
BIZ35_02250	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BIZ35_02290	COG1982	Orn Lys Arg decarboxylase major
BIZ35_02295	COG4476	Belongs to the UPF0223 family
BIZ35_02310	COG0483	inositol monophosphate 1-phosphatase activity
BIZ35_02320	COG1217	gtp-binding protein TYPA
BIZ35_02330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BIZ35_02335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BIZ35_02340	COG4838	Belongs to the UPF0358 family
BIZ35_02345	COG0772	Belongs to the SEDS family
BIZ35_02350	COG1612	heme a metabolic process
BIZ35_02355	COG0109	protoheme IX farnesyltransferase activity
BIZ35_02375	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BIZ35_02380	COG3336	cytochrome c oxidase
BIZ35_02390	COG2340	Cysteine-rich secretory protein family
BIZ35_02395	COG2050	protein possibly involved in aromatic compounds catabolism
BIZ35_02415	COG3679	Belongs to the UPF0342 family
BIZ35_02420	COG4471	UPF0298 protein
BIZ35_02430	COG0742	ribosomal rna small subunit methyltransferase
BIZ35_02435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BIZ35_02440	COG3314	Sporulation integral membrane protein YlbJ
BIZ35_02445	COG1752	Esterase of the alpha-beta hydrolase superfamily
BIZ35_02450	COG3480	Lon protease (S16) C-terminal proteolytic domain
BIZ35_02455	COG1323	Belongs to the UPF0348 family
BIZ35_02460	COG1399	metal-binding, possibly nucleic acid-binding protein
BIZ35_02465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BIZ35_02475	COG0454	-acetyltransferase
BIZ35_02480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BIZ35_02485	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BIZ35_02490	COG2001	Belongs to the MraZ family
BIZ35_02495	COG0275	rRNA processing
BIZ35_02500	COG4839	cell division protein FtsL
BIZ35_02505	COG0768	penicillin binding
BIZ35_02510	COG0768	penicillin binding
BIZ35_02525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BIZ35_02530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BIZ35_02535	COG0772	Belongs to the SEDS family
BIZ35_02540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIZ35_02545	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BIZ35_02550	COG3328	transposase activity
BIZ35_02555	COG0849	cell division
BIZ35_02560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BIZ35_02570	COG1191	sigma factor activity
BIZ35_02575	COG1191	sigma factor activity
BIZ35_02580	COG1873	PFAM PRC-barrel domain
BIZ35_02585	COG1388	LysM domain
BIZ35_02585	COG3584	3D domain protein
BIZ35_02595	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BIZ35_02600	COG1799	cell septum assembly
BIZ35_02605	COG0762	integral membrane protein
BIZ35_02610	COG2302	S4 RNA-binding domain
BIZ35_02615	COG3599	regulation of cell shape
BIZ35_02640	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BIZ35_02645	COG0564	pseudouridine synthase activity
BIZ35_02650	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BIZ35_02655	COG0540	Belongs to the ATCase OTCase family
BIZ35_02660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BIZ35_02675	COG0543	2 iron, 2 sulfur cluster binding
BIZ35_02680	COG0167	dihydroorotate dehydrogenase activity
BIZ35_02685	COG0284	orotidine-5'-phosphate decarboxylase activity
BIZ35_02690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BIZ35_02705	COG1917	Cupin 2, conserved barrel domain protein
BIZ35_02705	COG2207	Transcriptional regulator
BIZ35_02710	COG1070	Carbohydrate kinase
BIZ35_02715	COG4806	L-rhamnose isomerase
BIZ35_02720	COG0235	Class ii aldolase
BIZ35_02725	COG1454	alcohol dehydrogenase
BIZ35_02730	COG1803	Methylglyoxal synthase
BIZ35_02735	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BIZ35_02740	COG0477	Major facilitator Superfamily
BIZ35_02745	COG0477	Major facilitator Superfamily
BIZ35_02750	COG1309	transcriptional regulator
BIZ35_02760	COG0628	permease
BIZ35_02765	COG0561	phosphatase activity
BIZ35_02785	COG0720	synthase
BIZ35_02795	COG0385	Bile acid
BIZ35_02810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BIZ35_02815	COG1561	YicC-like family, N-terminal region
BIZ35_02820	COG2052	Domain of unknown function (DUF370)
BIZ35_02825	COG0194	GDP metabolic process
BIZ35_02830	COG1758	RNA polymerase activity
BIZ35_02835	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BIZ35_02840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BIZ35_02845	COG0242	peptide deformylase activity
BIZ35_02850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BIZ35_02855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BIZ35_02855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BIZ35_02860	COG0631	protein serine/threonine phosphatase activity
BIZ35_02865	COG0515	serine threonine protein kinase
BIZ35_02865	COG2815	serine threonine protein kinase
BIZ35_02875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BIZ35_02880	COG1564	THIamine pyrophosphokinase
BIZ35_02890	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BIZ35_02900	COG1302	Protein conserved in bacteria
BIZ35_02905	COG1461	Dihydroxyacetone kinase
BIZ35_02910	COG1760	l-serine dehydratase
BIZ35_02915	COG1760	l-serine dehydratase
BIZ35_02920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BIZ35_02925	COG1349	DNA-binding transcription factor activity
BIZ35_02930	COG0416	fatty acid biosynthetic process
BIZ35_02935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BIZ35_02940	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_02950	COG0571	ribonuclease III activity
BIZ35_02955	COG1196	nuclear chromosome segregation
BIZ35_02960	COG0552	protein localization to endoplasmic reticulum
BIZ35_02965	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BIZ35_02970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BIZ35_02980	COG1837	Belongs to the UPF0109 family
BIZ35_02990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BIZ35_02995	COG0336	Belongs to the RNA methyltransferase TrmD family
BIZ35_03010	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BIZ35_03025	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BIZ35_03030	COG0045	succinate-CoA ligase (ADP-forming) activity
BIZ35_03035	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BIZ35_03040	COG0758	DNA mediated transformation
BIZ35_03045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIZ35_03055	COG4974	Belongs to the 'phage' integrase family
BIZ35_03060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BIZ35_03070	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BIZ35_03075	COG1815	bacterial-type flagellum-dependent cell motility
BIZ35_03080	COG1558	bacterial-type flagellum-dependent cell motility
BIZ35_03085	COG1677	Flagellar hook-basal body complex protein FliE
BIZ35_03090	COG1766	The M ring may be actively involved in energy transduction
BIZ35_03095	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BIZ35_03100	COG1317	bacterial-type flagellum organization
BIZ35_03105	COG1157	protein secretion by the type III secretion system
BIZ35_03110	COG2882	bacterial-type flagellum organization
BIZ35_03125	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BIZ35_03135	COG4786	Flagellar basal body rod
BIZ35_03145	COG1580	Controls the rotational direction of flagella during chemotaxis
BIZ35_03150	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BIZ35_03155	COG1776	CheC inhibitor of MCP methylation
BIZ35_03155	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BIZ35_03160	COG2201	protein-glutamate methylesterase activity
BIZ35_03165	COG3190	flagellar
BIZ35_03170	COG1338	Plays a role in the flagellum-specific transport system
BIZ35_03175	COG1987	bacterial-type flagellum assembly
BIZ35_03180	COG1684	flagellar biosynthetic protein fliR
BIZ35_03185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BIZ35_03190	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BIZ35_03195	COG1419	protein localization to endoplasmic reticulum
BIZ35_03200	COG0455	bacterial-type flagellum organization
BIZ35_03205	COG2201	protein-glutamate methylesterase activity
BIZ35_03210	COG0643	Histidine kinase
BIZ35_03210	COG2198	Histidine kinase
BIZ35_03215	COG0835	chemotaxis
BIZ35_03220	COG1776	CheC inhibitor of MCP methylation
BIZ35_03225	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BIZ35_03230	COG1191	sigma factor activity
BIZ35_03240	COG0052	Belongs to the universal ribosomal protein uS2 family
BIZ35_03245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BIZ35_03250	COG0528	UMP kinase activity
BIZ35_03255	COG0233	cytoplasmic translational termination
BIZ35_03265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BIZ35_03270	COG4589	Belongs to the CDS family
BIZ35_03280	COG0750	zinc metalloprotease
BIZ35_03285	COG0442	prolyl-tRNA aminoacylation
BIZ35_03290	COG2176	DNA-directed DNA polymerase activity
BIZ35_03295	COG0779	Required for maturation of 30S ribosomal subunits
BIZ35_03300	COG0195	Participates in both transcription termination and antitermination
BIZ35_03305	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BIZ35_03310	COG1358	cellular component organization or biogenesis
BIZ35_03320	COG1550	Protein conserved in bacteria
BIZ35_03325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BIZ35_03330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BIZ35_03335	COG0196	riboflavin kinase activity
BIZ35_03340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BIZ35_03345	COG1185	polyribonucleotide nucleotidyltransferase activity
BIZ35_03350	COG0726	polysaccharide deacetylase
BIZ35_03355	COG0612	Peptidase, M16
BIZ35_03360	COG1873	PFAM PRC-barrel domain
BIZ35_03365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIZ35_03370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BIZ35_03375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BIZ35_03385	COG0527	aspartate kinase activity
BIZ35_03400	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BIZ35_03405	COG0740	serine-type endopeptidase activity
BIZ35_03415	COG4980	gas vesicle protein
BIZ35_03415	COG1674	ftsk spoiiie
BIZ35_03420	COG1744	ABC transporter substrate-binding protein PnrA-like
BIZ35_03425	COG3845	ABC transporter
BIZ35_03430	COG4603	Belongs to the binding-protein-dependent transport system permease family
BIZ35_03435	COG1079	Belongs to the binding-protein-dependent transport system permease family
BIZ35_03440	COG0612	Peptidase, M16
BIZ35_03445	COG0612	Peptidase, M16
BIZ35_03450	COG0300	oxidoreductase activity
BIZ35_03465	COG1426	Protein conserved in bacteria
BIZ35_03470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BIZ35_03475	COG1546	Belongs to the CinA family
BIZ35_03475	COG1058	Belongs to the CinA family
BIZ35_03490	COG1418	mRNA catabolic process
BIZ35_03495	COG1692	metallophosphoesterase
BIZ35_03500	COG2359	stage V sporulation protein S
BIZ35_03505	COG0826	peptidase U32
BIZ35_03510	COG0826	peptidase U32
BIZ35_03520	COG3829	transcription factor binding
BIZ35_03525	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_03535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BIZ35_03540	COG4550	Control of competence regulator ComK, YlbF/YmcA
BIZ35_03550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BIZ35_03555	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BIZ35_03585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BIZ35_03600	COG0464	growth
BIZ35_03605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BIZ35_03610	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BIZ35_03615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIZ35_03635	COG1321	iron dependent repressor
BIZ35_03645	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BIZ35_03655	COG1418	mRNA catabolic process
BIZ35_03660	COG0488	(ABC) transporter
BIZ35_03665	COG1413	lyase activity
BIZ35_03685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BIZ35_03690	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BIZ35_03695	COG1272	protein, Hemolysin III
BIZ35_03700	COG2755	lipolytic protein G-D-S-L family
BIZ35_03710	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BIZ35_03710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BIZ35_03715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIZ35_03720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIZ35_03730	COG0840	transmembrane signaling receptor activity
BIZ35_03735	COG4479	Belongs to the UPF0346 family
BIZ35_03755	COG1876	peptidase activity
BIZ35_03760	COG0793	Belongs to the peptidase S41A family
BIZ35_03760	COG3409	Peptidoglycan-binding domain 1 protein
BIZ35_03765	COG1846	Transcriptional regulator
BIZ35_03770	COG2340	Cysteine-rich secretory protein family
BIZ35_03775	COG0534	Mate efflux family protein
BIZ35_03790	COG1793	dna ligase
BIZ35_03790	COG3285	dna ligase
BIZ35_03795	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BIZ35_03800	COG0671	phosphoesterase, PA-phosphatase related
BIZ35_03805	COG1368	sulfuric ester hydrolase activity
BIZ35_03820	COG1331	Highly conserved protein containing a thioredoxin domain
BIZ35_03825	COG2814	Major facilitator Superfamily
BIZ35_03835	COG0745	RESPONSE REGULATOR receiver
BIZ35_03840	COG5002	protein histidine kinase activity
BIZ35_03850	COG0567	Dehydrogenase, E1 component
BIZ35_03855	COG0508	dehydrogenase complex catalyzes the overall conversion of
BIZ35_03860	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_03880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIZ35_03890	COG1054	Belongs to the UPF0176 family
BIZ35_03900	COG2135	peptidase activity
BIZ35_03910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIZ35_03915	COG0516	GMP reductase activity
BIZ35_03915	COG0517	IMP dehydrogenase activity
BIZ35_03920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIZ35_03920	COG0723	plastoquinol--plastocyanin reductase activity
BIZ35_03925	COG1388	LysM domain
BIZ35_03925	COG3584	3D domain protein
BIZ35_03930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIZ35_03935	COG1113	amino acid transport
BIZ35_03940	COG1280	lysine exporter protein (LysE YggA)
BIZ35_03945	COG0598	Magnesium transport protein CorA
BIZ35_03960	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BIZ35_03965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BIZ35_03970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BIZ35_03975	COG0131	Imidazoleglycerol-phosphate dehydratase
BIZ35_03980	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BIZ35_03990	COG0107	imidazoleglycerol-phosphate synthase activity
BIZ35_03995	COG0140	phosphoribosyl-ATP diphosphatase activity
BIZ35_03995	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BIZ35_04005	COG2391	methyltransferase activity
BIZ35_04010	COG2962	Rard protein
BIZ35_04015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BIZ35_04020	COG0569	domain protein
BIZ35_04040	COG2807	transmembrane transport
BIZ35_04045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BIZ35_04055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIZ35_04065	COG1278	Cold shock
BIZ35_04070	COG0302	gtp cyclohydrolase
BIZ35_04075	COG3634	alkyl hydroperoxide reductase activity
BIZ35_04090	COG0577	efflux transmembrane transporter activity
BIZ35_04095	COG1136	(ABC) transporter
BIZ35_04100	COG0642	Histidine kinase
BIZ35_04105	COG0745	RESPONSE REGULATOR receiver
BIZ35_04130	COG0640	Transcriptional regulator
BIZ35_04135	COG2814	Major facilitator Superfamily
BIZ35_04140	COG5039	Polysaccharide pyruvyl transferase
BIZ35_04145	COG1113	amino acid transport
BIZ35_04165	COG0477	Major facilitator Superfamily
BIZ35_04175	COG1132	(ABC) transporter
BIZ35_04180	COG1132	(ABC) transporter
BIZ35_04190	COG1380	Effector of murein hydrolase LrgA
BIZ35_04195	COG1346	cytolysis
BIZ35_04200	COG0318	PFAM AMP-dependent synthetase and ligase
BIZ35_04225	COG2309	aminopeptidase activity
BIZ35_04235	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BIZ35_04250	COG0824	Thioesterase
BIZ35_04260	COG4841	protein insertion into membrane
BIZ35_04265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BIZ35_04270	COG1832	CoA-binding protein
BIZ35_04275	COG0187	DNA topoisomerase II activity
BIZ35_04280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BIZ35_04295	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BIZ35_04300	COG0574	Belongs to the PEP-utilizing enzyme family
BIZ35_04300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BIZ35_04325	COG2070	2-Nitropropane dioxygenase
BIZ35_04335	COG0681	Belongs to the peptidase S26 family
BIZ35_04345	COG0473	3-isopropylmalate dehydrogenase activity
BIZ35_04355	COG2226	methyltransferase
BIZ35_04380	COG0456	acetyltransferase
BIZ35_04385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIZ35_04390	COG0456	acetyltransferase
BIZ35_04420	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BIZ35_04425	COG0351	phosphomethylpyrimidine kinase
BIZ35_04430	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_04435	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BIZ35_04440	COG0351	phosphomethylpyrimidine kinase
BIZ35_04450	COG2258	MOSC domain
BIZ35_04485	COG1309	transcriptional regulator
BIZ35_04490	COG2814	Major facilitator Superfamily
BIZ35_04495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIZ35_04500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIZ35_04510	COG1809	phosphosulfolactate synthase activity
BIZ35_04515	COG2045	Belongs to the ComB family
BIZ35_04520	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BIZ35_04525	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BIZ35_04535	COG0789	Transcriptional regulator
BIZ35_04540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIZ35_04545	COG0697	spore germination
BIZ35_04550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BIZ35_04555	COG0022	dehydrogenase e1 component
BIZ35_04560	COG0508	dehydrogenase complex catalyzes the overall conversion of
BIZ35_04565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BIZ35_04570	COG3284	Transcriptional regulator
BIZ35_04575	COG3264	Mechanosensitive ion channel
BIZ35_04575	COG1511	domain protein
BIZ35_04590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIZ35_04595	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BIZ35_04610	COG0183	Belongs to the thiolase family
BIZ35_04615	COG0318	PFAM AMP-dependent synthetase and ligase
BIZ35_04625	COG0561	phosphatase activity
BIZ35_04630	COG2322	membrane
BIZ35_04645	COG0039	L-malate dehydrogenase activity
BIZ35_04650	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_04655	COG2223	nitrite transmembrane transporter activity
BIZ35_04660	COG3773	Cell wall hydrolase
BIZ35_04665	COG0708	Exodeoxyribonuclease III
BIZ35_04675	COG0297	glycogen (starch) synthase activity
BIZ35_04680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BIZ35_04685	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BIZ35_04690	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BIZ35_04715	COG1247	-acetyltransferase
BIZ35_04720	COG0494	nUDIX hydrolase
BIZ35_04725	COG1914	H( )-stimulated, divalent metal cation uptake system
BIZ35_04730	COG0783	Belongs to the Dps family
BIZ35_04740	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BIZ35_04745	COG1131	(ABC) transporter
BIZ35_04770	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BIZ35_04780	COG2030	dehydratase
BIZ35_04785	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_04800	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BIZ35_04805	COG0709	Synthesizes selenophosphate from selenide and ATP
BIZ35_04820	COG0701	Predicted permease
BIZ35_04825	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BIZ35_04830	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BIZ35_04840	COG1252	NADH dehydrogenase
BIZ35_04845	COG2404	hydrolase activity, acting on ester bonds
BIZ35_04855	COG4990	cell redox homeostasis
BIZ35_04860	COG0789	Transcriptional regulator
BIZ35_04885	COG0436	Aminotransferase
BIZ35_04890	COG0165	Argininosuccinate lyase
BIZ35_04895	COG0137	argininosuccinate synthase activity
BIZ35_04900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BIZ35_04905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BIZ35_04910	COG0505	Belongs to the CarA family
BIZ35_04915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BIZ35_04920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BIZ35_04925	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BIZ35_04930	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BIZ35_04945	COG3546	catalase activity
BIZ35_04965	COG1619	proteins homologs of microcin C7 resistance protein MccF
BIZ35_04970	COG2027	D-alanyl-D-alanine carboxypeptidase
BIZ35_04975	COG0204	Acyl-transferase
BIZ35_04985	COG4846	Membrane protein involved in cytochrome C biogenesis
BIZ35_04990	COG2201	protein-glutamate methylesterase activity
BIZ35_04995	COG0785	Cytochrome C biogenesis protein
BIZ35_05000	COG3763	UPF0154 protein
BIZ35_05015	COG4224	UPF0291 protein
BIZ35_05020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BIZ35_05030	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BIZ35_05035	COG0174	glutamine synthetase
BIZ35_05040	COG0789	Transcriptional regulator
BIZ35_05045	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BIZ35_05075	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BIZ35_05080	COG0116	Belongs to the methyltransferase superfamily
BIZ35_05095	COG4474	Belongs to the UPF0398 family
BIZ35_05105	COG3359	exonuclease
BIZ35_05110	COG1205	dead DEAH box helicase
BIZ35_05110	COG1111	helicase
BIZ35_05115	COG0071	Belongs to the small heat shock protein (HSP20) family
BIZ35_05140	COG3331	DNA recombination
BIZ35_05145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIZ35_05145	COG4499	WXG100 protein secretion system (Wss), protein YukC
BIZ35_05150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BIZ35_05155	COG3935	DnaD domain protein
BIZ35_05160	COG0017	Asparaginyl-tRNA synthetase
BIZ35_05175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BIZ35_05175	COG1199	ATP-dependent helicase activity
BIZ35_05180	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BIZ35_05185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BIZ35_05205	COG0438	transferase activity, transferring glycosyl groups
BIZ35_05210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BIZ35_05215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BIZ35_05220	COG1694	Mazg nucleotide pyrophosphohydrolase
BIZ35_05225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIZ35_05235	COG2738	Putative neutral zinc metallopeptidase
BIZ35_05245	COG4347	Protein of unknown function (DUF1405)
BIZ35_05255	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BIZ35_05270	COG5582	Belongs to the UPF0302 family
BIZ35_05275	COG0457	Tetratricopeptide repeat
BIZ35_05285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BIZ35_05290	COG0287	Prephenate dehydrogenase
BIZ35_05295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BIZ35_05300	COG4401	Chorismate mutase type I
BIZ35_05305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BIZ35_05310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BIZ35_05315	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BIZ35_05320	COG0105	UTP biosynthetic process
BIZ35_05325	COG0142	geranyltranstransferase activity
BIZ35_05330	COG2226	methyltransferase
BIZ35_05335	COG0142	geranyltranstransferase activity
BIZ35_05350	COG0776	regulation of translation
BIZ35_05355	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BIZ35_05375	COG1160	GTP binding
BIZ35_05390	COG0539	negative regulation of cytoplasmic translation
BIZ35_05395	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BIZ35_05400	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BIZ35_05405	COG2959	enzyme of heme biosynthesis
BIZ35_05410	COG3409	Peptidoglycan-binding domain 1 protein
BIZ35_05410	COG3773	Cell wall hydrolase
BIZ35_05415	COG2339	peptidase activity
BIZ35_05420	COG0492	ferredoxin-NADP+ reductase activity
BIZ35_05425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BIZ35_05435	COG1408	metallophosphoesterase
BIZ35_05450	COG3546	catalase activity
BIZ35_05465	COG1266	CAAX protease self-immunity
BIZ35_05470	COG0514	ATP-dependent DNA helicase (RecQ)
BIZ35_05480	COG1141	Ferredoxin
BIZ35_05485	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BIZ35_05490	COG0741	lytic transglycosylase activity
BIZ35_05490	COG0739	heme binding
BIZ35_05490	COG1196	nuclear chromosome segregation
BIZ35_05495	COG5002	protein histidine kinase activity
BIZ35_05500	COG0745	RESPONSE REGULATOR receiver
BIZ35_05505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BIZ35_05510	COG1333	cytochrome c biogenesis protein
BIZ35_05515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ35_05520	COG1187	pseudouridine synthase activity
BIZ35_05525	COG0700	Nucleoside recognition
BIZ35_05530	COG2715	membrane protein required for spore maturation
BIZ35_05535	COG1686	Belongs to the peptidase S11 family
BIZ35_05540	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BIZ35_05560	COG0697	spore germination
BIZ35_05580	COG1191	sigma factor activity
BIZ35_05595	COG1686	Belongs to the peptidase S11 family
BIZ35_05600	COG4974	Belongs to the 'phage' integrase family
BIZ35_05610	COG0735	belongs to the Fur family
BIZ35_05615	COG1300	Membrane
BIZ35_05620	COG1379	DNA repair
BIZ35_05635	COG0667	Aldo Keto reductase
BIZ35_05650	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
BIZ35_05655	COG3853	Toxic anion resistance protein (TelA)
BIZ35_05660	COG1073	alpha beta
BIZ35_05665	COG1388	LysM domain
BIZ35_05665	COG3858	chitin binding
BIZ35_05675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIZ35_05680	COG0300	oxidoreductase activity
BIZ35_05690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIZ35_05700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BIZ35_05705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIZ35_05715	COG2195	Cleaves the N-terminal amino acid of tripeptides
BIZ35_05725	COG1376	ErfK ybiS ycfS ynhG family protein
BIZ35_05735	COG1105	Belongs to the carbohydrate kinase PfkB family
BIZ35_05740	COG0508	dehydrogenase complex catalyzes the overall conversion of
BIZ35_05745	COG0022	dehydrogenase e1 component
BIZ35_05750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BIZ35_05755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BIZ35_05765	COG3829	transcription factor binding
BIZ35_05765	COG3290	protein histidine kinase activity
BIZ35_05770	COG3290	protein histidine kinase activity
BIZ35_05770	COG3829	transcription factor binding
BIZ35_05780	COG0584	glycerophosphoryl diester phosphodiesterase
BIZ35_05785	COG0745	RESPONSE REGULATOR receiver
BIZ35_05795	COG0750	zinc metalloprotease
BIZ35_05800	COG0497	DNA recombination
BIZ35_05810	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BIZ35_05815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BIZ35_05830	COG1570	exodeoxyribonuclease VII activity
BIZ35_05845	COG1302	Protein conserved in bacteria
BIZ35_05850	COG0439	Biotin carboxylase
BIZ35_05855	COG0511	ligase activity, forming carbon-carbon bonds
BIZ35_05895	COG3854	ATPases associated with a variety of cellular activities
BIZ35_05900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BIZ35_05905	COG0006	proline dipeptidase activity
BIZ35_05910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BIZ35_05920	COG3872	metal-dependent enzyme
BIZ35_05930	COG1752	Esterase of the alpha-beta hydrolase superfamily
BIZ35_05940	COG3327	negative regulation of DNA-templated transcription, initiation
BIZ35_05945	COG0183	Belongs to the thiolase family
BIZ35_05950	COG1250	3-hydroxyacyl-CoA dehydrogenase
BIZ35_05955	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_05960	COG1024	Enoyl-CoA hydratase
BIZ35_05965	COG0492	ferredoxin-NADP+ reductase activity
BIZ35_05975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIZ35_05980	COG0095	Lipoate-protein ligase
BIZ35_05985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BIZ35_05990	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BIZ35_06000	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BIZ35_06005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BIZ35_06020	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BIZ35_06045	COG4537	Required for transformation and DNA binding
BIZ35_06050	COG1459	type II secretion system
BIZ35_06055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BIZ35_06070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIZ35_06080	COG1940	carbohydrate kinase activity
BIZ35_06085	COG4483	Protein conserved in bacteria
BIZ35_06090	COG0705	Rhomboid family
BIZ35_06090	COG0457	Tetratricopeptide repeat
BIZ35_06095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BIZ35_06105	COG0768	penicillin binding
BIZ35_06110	COG0477	Major facilitator Superfamily
BIZ35_06115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BIZ35_06125	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BIZ35_06130	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BIZ35_06135	COG0735	belongs to the Fur family
BIZ35_06140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BIZ35_06145	COG1121	(ABC) transporter
BIZ35_06155	COG3883	PFAM NLP P60 protein
BIZ35_06155	COG0791	NLP P60 protein
BIZ35_06160	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BIZ35_06165	COG0513	Belongs to the DEAD box helicase family
BIZ35_06175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BIZ35_06180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BIZ35_06185	COG2384	SAM-dependent methyltransferase
BIZ35_06190	COG2010	Cytochrome c
BIZ35_06200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BIZ35_06205	COG0358	DNA primase activity
BIZ35_06215	COG0517	IMP dehydrogenase activity
BIZ35_06220	COG1381	Involved in DNA repair and RecF pathway recombination
BIZ35_06235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BIZ35_06240	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BIZ35_06245	COG1480	7TM receptor with intracellular HD hydrolase
BIZ35_06250	COG1702	phosphate starvation-inducible protein PhoH
BIZ35_06265	COG1610	YqeY-like protein
BIZ35_06280	COG1283	sodium-dependent phosphate transmembrane transporter activity
BIZ35_06285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BIZ35_06290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BIZ35_06295	COG2264	protein methyltransferase activity
BIZ35_06305	COG0443	Heat shock 70 kDa protein
BIZ35_06310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BIZ35_06320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BIZ35_06325	COG0481	GTPase activity
BIZ35_06330	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIZ35_06335	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BIZ35_06340	COG0268	Binds directly to 16S ribosomal RNA
BIZ35_06345	COG1466	dna polymerase III delta subunit
BIZ35_06350	COG2333	competence protein COMEC
BIZ35_06350	COG0658	competence protein
BIZ35_06355	COG2131	deaminase
BIZ35_06360	COG1596	polysaccharide export
BIZ35_06360	COG1555	photosystem II stabilization
BIZ35_06365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIZ35_06370	COG2226	methyltransferase
BIZ35_06375	COG0799	negative regulation of ribosome biogenesis
BIZ35_06380	COG1713	HD superfamily hydrolase involved in NAD metabolism
BIZ35_06385	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BIZ35_06390	COG1534	Rna-binding protein
BIZ35_06400	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BIZ35_06405	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BIZ35_06410	COG0247	lactate metabolic process
BIZ35_06415	COG0277	FAD linked oxidase domain protein
BIZ35_06420	COG3835	regulator
BIZ35_06425	COG2132	Multicopper oxidase
BIZ35_06430	COG0071	Belongs to the small heat shock protein (HSP20) family
BIZ35_06435	COG2210	Belongs to the sulfur carrier protein TusA family
BIZ35_06450	COG0446	pyridine nucleotide-disulphide oxidoreductase
BIZ35_06460	COG2132	Multicopper oxidase
BIZ35_06465	COG0071	Belongs to the small heat shock protein (HSP20) family
BIZ35_06475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ35_06485	COG1704	LemA family
BIZ35_06495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIZ35_06520	COG1183	phosphatidylcholine synthase activity
BIZ35_06540	COG0450	alkyl hydroperoxide reductase
BIZ35_06565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BIZ35_06570	COG0572	uridine kinase
BIZ35_06575	COG4122	O-methyltransferase activity
BIZ35_06580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BIZ35_06585	COG3906	Belongs to the UPF0473 family
BIZ35_06590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BIZ35_06595	COG4472	Bacterial protein of unknown function (DUF965)
BIZ35_06600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BIZ35_06605	COG0628	permease
BIZ35_06620	COG1522	sequence-specific DNA binding
BIZ35_06635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BIZ35_06645	COG0482	sulfurtransferase activity
BIZ35_06650	COG1104	cysteine desulfurase activity
BIZ35_06655	COG1959	2 iron, 2 sulfur cluster binding
BIZ35_06670	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_06675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BIZ35_06680	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BIZ35_06685	COG0385	Bile acid
BIZ35_06695	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BIZ35_06700	COG0124	histidyl-tRNA synthetase
BIZ35_06705	COG3103	Sh3 type 3 domain protein
BIZ35_06705	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIZ35_06705	COG4991	sh3 domain protein
BIZ35_06710	COG2814	Major facilitator Superfamily
BIZ35_06715	COG1566	PFAM secretion protein HlyD family protein
BIZ35_06720	COG1846	Transcriptional regulator
BIZ35_06725	COG1490	D-aminoacyl-tRNA deacylase activity
BIZ35_06730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BIZ35_06735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIZ35_06740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BIZ35_06740	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BIZ35_06745	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BIZ35_06745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BIZ35_06755	COG2244	polysaccharide biosynthetic process
BIZ35_06760	COG2323	membrane
BIZ35_06770	COG1862	Preprotein translocase
BIZ35_06775	COG0343	queuine tRNA-ribosyltransferase activity
BIZ35_06780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BIZ35_06795	COG0632	four-way junction helicase activity
BIZ35_06805	COG0217	transcriptional regulatory protein
BIZ35_06820	COG1827	regulation of RNA biosynthetic process
BIZ35_06825	COG0077	Prephenate dehydratase
BIZ35_06830	COG4492	Belongs to the UPF0735 family
BIZ35_06835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BIZ35_06840	COG3290	protein histidine kinase activity
BIZ35_06845	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BIZ35_06850	COG2868	ribosomal protein
BIZ35_06855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BIZ35_06860	COG1530	ribonuclease E activity
BIZ35_06865	COG1994	Peptidase M50
BIZ35_06875	COG2894	cell division
BIZ35_06880	COG0850	regulation of cytokinetic process
BIZ35_06890	COG1792	Involved in formation and maintenance of cell shape
BIZ35_06895	COG1077	Cell shape determining protein MreB Mrl
BIZ35_06900	COG2003	Belongs to the UPF0758 family
BIZ35_06910	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BIZ35_06940	COG1459	type II secretion system
BIZ35_06950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BIZ35_06985	COG0285	dihydrofolate synthase activity
BIZ35_06990	COG0525	valine-tRNA ligase activity
BIZ35_07000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BIZ35_07005	COG1388	LysM domain
BIZ35_07005	COG1388	LysM domain
BIZ35_07010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BIZ35_07015	COG0113	porphobilinogen synthase activity
BIZ35_07030	COG0181	hydroxymethylbilane synthase activity
BIZ35_07035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BIZ35_07050	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BIZ35_07055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BIZ35_07060	COG1067	ATP-dependent peptidase activity
BIZ35_07060	COG0470	DNA polymerase III
BIZ35_07070	COG0544	peptidyl-prolyl cis-trans isomerase activity
BIZ35_07075	COG0457	Tetratricopeptide repeat
BIZ35_07075	COG1477	protein flavinylation
BIZ35_07105	COG0622	Phosphoesterase
BIZ35_07110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BIZ35_07115	COG5401	PFAM Sporulation and spore germination
BIZ35_07125	COG5577	PFAM Coat F domain
BIZ35_07130	COG1063	alcohol dehydrogenase
BIZ35_07135	COG5577	PFAM Coat F domain
BIZ35_07150	COG1846	Transcriptional regulator
BIZ35_07180	COG2197	response regulator
BIZ35_07185	COG0824	Thioesterase
BIZ35_07190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BIZ35_07195	COG1053	succinate dehydrogenase
BIZ35_07200	COG2009	succinate dehydrogenase
BIZ35_07205	COG1719	4-vinyl reductase, 4VR
BIZ35_07220	COG0322	excinuclease ABC activity
BIZ35_07225	COG3118	belongs to the thioredoxin family
BIZ35_07230	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BIZ35_07235	COG2086	electron transfer activity
BIZ35_07240	COG1024	Enoyl-CoA hydratase
BIZ35_07245	COG1309	transcriptional regulator
BIZ35_07250	COG0318	PFAM AMP-dependent synthetase and ligase
BIZ35_07255	COG1193	negative regulation of DNA recombination
BIZ35_07260	COG1796	DNA polymerase
BIZ35_07260	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BIZ35_07265	COG1286	toxin biosynthetic process
BIZ35_07270	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BIZ35_07280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIZ35_07280	COG0072	phenylalanine-tRNA ligase activity
BIZ35_07285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BIZ35_07290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIZ35_07325	COG2329	Antibiotic biosynthesis monooxygenase
BIZ35_07335	COG1695	Transcriptional regulator
BIZ35_07355	COG0431	NADPH-dependent FMN reductase
BIZ35_07385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BIZ35_07395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BIZ35_07410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BIZ35_07420	COG1484	DNA-dependent DNA replication
BIZ35_07425	COG3611	Membrane attachment protein
BIZ35_07430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BIZ35_07435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BIZ35_07440	COG0237	dephospho-CoA kinase activity
BIZ35_07445	COG1971	Probably functions as a manganese efflux pump
BIZ35_07450	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BIZ35_07455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIZ35_07455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIZ35_07465	COG0039	L-malate dehydrogenase activity
BIZ35_07470	COG0538	isocitrate dehydrogenase activity
BIZ35_07475	COG0372	Belongs to the citrate synthase family
BIZ35_07480	COG2707	UPF0756 membrane protein
BIZ35_07485	COG0628	permease
BIZ35_07495	COG0205	6-phosphofructokinase activity
BIZ35_07500	COG0825	malonyl-CoA metabolic process
BIZ35_07505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BIZ35_07510	COG0281	malic enzyme
BIZ35_07515	COG0587	DNA-directed DNA polymerase activity
BIZ35_07530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BIZ35_07540	COG4109	DRTGG domain
BIZ35_07545	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BIZ35_07550	COG0006	proline dipeptidase activity
BIZ35_07560	COG0589	response to stress
BIZ35_07570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BIZ35_07575	COG0827	DNA restriction-modification system
BIZ35_07580	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BIZ35_07585	COG3874	Sporulation protein YtfJ
BIZ35_07595	COG1714	RDD family
BIZ35_07600	COG0616	signal peptide processing
BIZ35_07605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BIZ35_07615	COG0301	tRNA thio-modification
BIZ35_07620	COG1104	cysteine desulfurase activity
BIZ35_07625	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BIZ35_07630	COG1309	transcriptional regulator
BIZ35_07635	COG1956	GAF domain-containing protein
BIZ35_07640	COG2203	Gaf domain
BIZ35_07640	COG2199	diguanylate cyclase activity
BIZ35_07645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BIZ35_07660	COG0506	proline dehydrogenase activity
BIZ35_07665	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_07670	COG3829	transcription factor binding
BIZ35_07670	COG3290	protein histidine kinase activity
BIZ35_07685	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BIZ35_07695	COG3383	formate dehydrogenase (NAD+) activity
BIZ35_07700	COG2427	Protein of unknown function (DUF1641)
BIZ35_07705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BIZ35_07710	COG0315	cyclic pyranopterin monophosphate synthase activity
BIZ35_07715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BIZ35_07720	COG0314	molybdopterin synthase activity
BIZ35_07725	COG1763	Mo-molybdopterin cofactor biosynthetic process
BIZ35_07730	COG0303	'Molybdopterin
BIZ35_07745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BIZ35_07755	COG4149	molybdate abc transporter
BIZ35_07765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BIZ35_07770	COG0454	-acetyltransferase
BIZ35_07775	COG0517	IMP dehydrogenase activity
BIZ35_07780	COG0123	including yeast histone deacetylase and acetoin utilization protein
BIZ35_07790	COG1605	Chorismate mutase
BIZ35_07790	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BIZ35_07795	COG4980	gas vesicle protein
BIZ35_07805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BIZ35_07810	COG1674	ftsk spoiiie
BIZ35_07820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIZ35_07825	COG4848	Belongs to the UPF0354 family
BIZ35_07830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ35_07835	COG2208	phosphoserine phosphatase activity
BIZ35_07840	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BIZ35_07850	COG0784	Response regulator, receiver
BIZ35_07850	COG5002	protein histidine kinase activity
BIZ35_07875	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BIZ35_07880	COG1363	Peptidase, m42
BIZ35_07885	COG5584	Small secreted protein
BIZ35_07890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIZ35_07895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BIZ35_07905	COG0510	thiamine kinase activity
BIZ35_07925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIZ35_07930	COG1349	DNA-binding transcription factor activity
BIZ35_07935	COG2244	polysaccharide biosynthetic process
BIZ35_07955	COG0495	leucyl-tRNA aminoacylation
BIZ35_07960	COG2814	Major facilitator Superfamily
BIZ35_07970	COG0275	rRNA processing
BIZ35_07985	COG2267	carboxylic ester hydrolase activity
BIZ35_07990	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BIZ35_07995	COG0367	asparagine synthase
BIZ35_08000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BIZ35_08005	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BIZ35_08015	COG1506	peptidase
BIZ35_08020	COG0655	NAD(P)H dehydrogenase (quinone) activity
BIZ35_08025	COG1070	Carbohydrate kinase
BIZ35_08030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIZ35_08035	COG1116	anion transmembrane transporter activity
BIZ35_08040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIZ35_08055	COG0783	Belongs to the Dps family
BIZ35_08060	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BIZ35_08065	COG0803	Belongs to the bacterial solute-binding protein 9 family
BIZ35_08075	COG4948	Mandelate Racemase Muconate Lactonizing
BIZ35_08080	COG0318	PFAM AMP-dependent synthetase and ligase
BIZ35_08085	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BIZ35_08090	COG0596	Alpha beta hydrolase
BIZ35_08095	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BIZ35_08100	COG1169	isochorismate synthase
BIZ35_08105	COG1575	Belongs to the MenA family. Type 1 subfamily
BIZ35_08250	COG1285	pathogenesis
BIZ35_08265	COG2217	Heavy metal translocating P-type atpase
BIZ35_08270	COG2608	mercury ion transmembrane transporter activity
BIZ35_08295	COG1522	sequence-specific DNA binding
BIZ35_08315	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIZ35_08340	COG5002	protein histidine kinase activity
BIZ35_08345	COG0745	RESPONSE REGULATOR receiver
BIZ35_08350	COG1388	LysM domain
BIZ35_08355	COG4221	oxidoreductase activity
BIZ35_08365	COG0726	polysaccharide deacetylase
BIZ35_08385	COG0038	chloride channel
BIZ35_08395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BIZ35_08395	COG0425	Belongs to the sulfur carrier protein TusA family
BIZ35_08400	COG1937	Protein conserved in bacteria
BIZ35_08410	COG1525	nuclease
BIZ35_08415	COG2190	(PTS) system
BIZ35_08435	COG3534	alpha-L-arabinofuranosidase
BIZ35_08440	COG2160	L-arabinose isomerase activity
BIZ35_08460	COG0395	ABC-type sugar transport system, permease component
BIZ35_08465	COG1175	transmembrane transport
BIZ35_08470	COG1653	transport
BIZ35_08475	COG1609	Transcriptional regulator
BIZ35_08480	COG3940	Belongs to the glycosyl hydrolase 43 family
BIZ35_08485	COG2223	nitrite transmembrane transporter activity
BIZ35_08490	COG3507	Belongs to the glycosyl hydrolase 43 family
BIZ35_08495	COG3328	transposase activity
BIZ35_08500	COG3507	Belongs to the glycosyl hydrolase 43 family
BIZ35_08505	COG0840	transmembrane signaling receptor activity
BIZ35_08520	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_08525	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BIZ35_08540	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_08560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BIZ35_08570	COG2155	Conserved Protein
BIZ35_08580	COG1098	S1 RNA binding domain
BIZ35_08595	COG1902	pentaerythritol trinitrate reductase activity
BIZ35_08600	COG0656	L-ascorbic acid biosynthetic process
BIZ35_08620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BIZ35_08630	COG2814	Major facilitator Superfamily
BIZ35_08635	COG2050	protein possibly involved in aromatic compounds catabolism
BIZ35_08650	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BIZ35_08660	COG0697	spore germination
BIZ35_08670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BIZ35_08675	COG3584	3D domain protein
BIZ35_08690	COG1252	NADH dehydrogenase
BIZ35_08695	COG0492	ferredoxin-NADP+ reductase activity
BIZ35_08720	COG0316	Belongs to the HesB IscA family
BIZ35_08725	COG4837	Protein of unknown function (DUF1462)
BIZ35_08730	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BIZ35_08740	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BIZ35_08745	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BIZ35_08750	COG0647	UMP catabolic process
BIZ35_08755	COG2445	Protein of unknown function DUF86
BIZ35_08760	COG4470	Protein conserved in bacteria
BIZ35_08765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BIZ35_08770	COG0739	heme binding
BIZ35_08780	COG3377	Domain of unknown function (DUF1805)
BIZ35_08785	COG0737	Belongs to the 5'-nucleotidase family
BIZ35_08790	COG0719	Fe-S assembly protein
BIZ35_08795	COG0822	iron-sulfur transferase activity
BIZ35_08800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BIZ35_08805	COG0719	Fe-S assembly protein
BIZ35_08810	COG0396	ATPase activity
BIZ35_08825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ35_08830	COG0509	glycine decarboxylation via glycine cleavage system
BIZ35_08835	COG1393	Belongs to the ArsC family
BIZ35_08840	COG1960	acyl-CoA dehydrogenase activity
BIZ35_08845	COG0183	Belongs to the thiolase family
BIZ35_08850	COG1024	Enoyl-CoA hydratase
BIZ35_08850	COG1250	3-hydroxyacyl-CoA dehydrogenase
BIZ35_08860	COG5577	PFAM Coat F domain
BIZ35_08865	COG0772	Belongs to the SEDS family
BIZ35_08870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ35_08880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BIZ35_08895	COG0753	catalase activity
BIZ35_08900	COG0671	phosphoesterase, PA-phosphatase related
BIZ35_08910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIZ35_08930	COG1595	DNA-templated transcription, initiation
BIZ35_08935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIZ35_08950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BIZ35_08960	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BIZ35_08965	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_08970	COG2211	Major facilitator Superfamily
BIZ35_08975	COG1904	glucuronate isomerase
BIZ35_08980	COG2721	sulfolactate sulfo-lyase activity
BIZ35_08985	COG0246	Mannitol dehydrogenase
BIZ35_08995	COG0800	Aldolase
BIZ35_09000	COG1414	Transcriptional regulator
BIZ35_09020	COG0488	(ABC) transporter
BIZ35_09090	COG0557	exoribonuclease II activity
BIZ35_09100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BIZ35_09105	COG0148	phosphopyruvate hydratase activity
BIZ35_09110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BIZ35_09120	COG0126	phosphoglycerate kinase activity
BIZ35_09140	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BIZ35_09160	COG3383	formate dehydrogenase (NAD+) activity
BIZ35_09200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIZ35_09210	COG4608	Belongs to the ABC transporter superfamily
BIZ35_09215	COG0791	NLP P60 protein
BIZ35_09220	COG4166	transmembrane transport
BIZ35_09225	COG0444	Belongs to the ABC transporter superfamily
BIZ35_09230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIZ35_09235	COG0601	transmembrane transport
BIZ35_09240	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BIZ35_09250	COG0598	Magnesium transport protein CorA
BIZ35_09265	COG2719	SpoVR family
BIZ35_09270	COG3594	Acyltransferase
BIZ35_09295	COG1392	Phosphate transport regulator
BIZ35_09300	COG0306	phosphate transporter
BIZ35_09315	COG2718	Belongs to the UPF0229 family
BIZ35_09320	COG2766	serine protein kinase
BIZ35_09330	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BIZ35_09345	COG2095	MarC family integral membrane protein
BIZ35_09360	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BIZ35_09365	COG0596	Alpha beta hydrolase
BIZ35_09370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIZ35_09375	COG0765	amino acid transport
BIZ35_09380	COG1126	abc transporter atp-binding protein
BIZ35_09385	COG2116	formate transmembrane transporter activity
BIZ35_09410	COG1882	Formate acetyltransferase
BIZ35_09415	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BIZ35_09420	COG0431	NADPH-dependent FMN reductase
BIZ35_09435	COG1131	(ABC) transporter
BIZ35_09460	COG0745	RESPONSE REGULATOR receiver
BIZ35_09465	COG3850	Histidine kinase
BIZ35_09465	COG5002	protein histidine kinase activity
BIZ35_09515	COG4977	sequence-specific DNA binding
BIZ35_09515	COG1917	Cupin 2, conserved barrel domain protein
BIZ35_09520	COG1874	Beta-galactosidase
BIZ35_09540	COG2271	Major facilitator Superfamily
BIZ35_09560	COG0697	spore germination
BIZ35_09575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIZ35_09695	COG3527	Alpha-acetolactate decarboxylase
BIZ35_09700	COG0028	Belongs to the TPP enzyme family
BIZ35_09705	COG0583	DNA-binding transcription factor activity
BIZ35_09710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIZ35_09715	COG0549	Belongs to the carbamate kinase family
BIZ35_09725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BIZ35_09735	COG0735	belongs to the Fur family
BIZ35_09750	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BIZ35_09755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIZ35_09760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIZ35_09765	COG1116	anion transmembrane transporter activity
BIZ35_09770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIZ35_09775	COG2814	Major facilitator Superfamily
BIZ35_09790	COG4129	membrane
BIZ35_09795	COG1737	Transcriptional regulator
BIZ35_09800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_09800	COG1263	PTS System
BIZ35_09805	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BIZ35_09815	COG1132	(ABC) transporter
BIZ35_09820	COG3557	Belongs to the UPF0374 family
BIZ35_09835	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_09840	COG0583	DNA-binding transcription factor activity
BIZ35_09845	COG0070	glutamate synthase
BIZ35_09845	COG0069	glutamate synthase activity
BIZ35_09845	COG0067	glutamate synthase
BIZ35_09850	COG0493	'glutamate synthase
BIZ35_09870	COG1129	ABC transporter
BIZ35_09875	COG1194	a g-specific adenine glycosylase
BIZ35_09880	COG1988	membrane-bound metal-dependent
BIZ35_09905	COG0159	tryptophan synthase activity
BIZ35_09910	COG0133	tryptophan synthase activity
BIZ35_09915	COG0134	indole-3-glycerol-phosphate synthase activity
BIZ35_09920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BIZ35_09925	COG0512	Glutamine amidotransferase of anthranilate synthase
BIZ35_09925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BIZ35_09940	COG0577	efflux transmembrane transporter activity
BIZ35_09950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIZ35_09970	COG1131	(ABC) transporter
BIZ35_10010	COG2197	response regulator
BIZ35_10015	COG4585	Histidine kinase
BIZ35_10025	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_10025	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_10035	COG0058	SHG alpha-glucan phosphorylase activity
BIZ35_10040	COG0840	transmembrane signaling receptor activity
BIZ35_10045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIZ35_10050	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BIZ35_10055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BIZ35_10070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BIZ35_10075	COG0066	3-isopropylmalate dehydratase activity
BIZ35_10080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BIZ35_10090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BIZ35_10095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BIZ35_10100	COG0440	acetolactate synthase activity
BIZ35_10105	COG0028	Belongs to the TPP enzyme family
BIZ35_10110	COG0129	dihydroxy-acid dehydratase activity
BIZ35_10120	COG1114	Component of the transport system for branched-chain amino acids
BIZ35_10125	COG1366	Belongs to the anti-sigma-factor antagonist family
BIZ35_10160	COG0670	Belongs to the BI1 family
BIZ35_10165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIZ35_10170	COG2223	nitrite transmembrane transporter activity
BIZ35_10175	COG3279	Response regulator of the LytR AlgR family
BIZ35_10180	COG3275	phosphorelay sensor kinase activity
BIZ35_10185	COG0252	asparaginase activity
BIZ35_10190	COG2132	Multicopper oxidase
BIZ35_10195	COG1309	transcriptional regulator
BIZ35_10200	COG1511	domain protein
BIZ35_10235	COG0840	transmembrane signaling receptor activity
BIZ35_10235	COG5278	phosphoserine phosphatase activity
BIZ35_10240	COG3739	integral membrane protein
BIZ35_10245	COG3655	Transcriptional regulator
BIZ35_10260	COG1823	symporter activity
BIZ35_10265	COG2839	Protein conserved in bacteria
BIZ35_10285	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
BIZ35_10310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIZ35_10315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BIZ35_10320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BIZ35_10325	COG0840	transmembrane signaling receptor activity
BIZ35_10345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BIZ35_10350	COG1132	(ABC) transporter
BIZ35_10355	COG1846	Transcriptional regulator
BIZ35_10380	COG0798	PFAM Bile acid sodium symporter
BIZ35_10420	COG0024	Methionine aminopeptidase
BIZ35_10440	COG0464	growth
BIZ35_10505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BIZ35_10510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BIZ35_10535	COG0387	Pfam Sodium calcium exchanger
BIZ35_10540	COG0477	Major facilitator Superfamily
BIZ35_10545	COG1295	ribonuclease BN
BIZ35_10550	COG4840	Belongs to the UPF0435 family
BIZ35_10555	COG0024	Methionine aminopeptidase
BIZ35_10560	COG0693	protein deglycase activity
BIZ35_10565	COG1360	Flagellar Motor Protein
BIZ35_10570	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BIZ35_10580	COG3189	MarR family transcriptional regulator
BIZ35_10590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BIZ35_10595	COG1607	acyl-coa hydrolase
BIZ35_10600	COG1077	Cell shape determining protein MreB Mrl
BIZ35_10605	COG2268	Band 7 protein
BIZ35_10610	COG1585	Membrane protein implicated in regulation of membrane protease activity
BIZ35_10615	COG0626	cystathionine gamma-synthase activity
BIZ35_10620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BIZ35_10625	COG1854	S-ribosylhomocysteine lyase activity
BIZ35_10635	COG0288	reversible hydration of carbon dioxide
BIZ35_10645	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIZ35_10660	COG2197	response regulator
BIZ35_10680	COG4086	secreted protein
BIZ35_10685	COG0737	Belongs to the 5'-nucleotidase family
BIZ35_10700	COG3620	sequence-specific DNA binding
BIZ35_10705	COG3328	transposase activity
BIZ35_10725	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BIZ35_10730	COG1518	maintenance of DNA repeat elements
BIZ35_10790	COG1304	FMN binding
BIZ35_10795	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BIZ35_10800	COG0166	Belongs to the GPI family
BIZ35_10805	COG0025	NhaP-type Na H and K H
BIZ35_10815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_10815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIZ35_10815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIZ35_10820	COG1349	DNA-binding transcription factor activity
BIZ35_10830	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
BIZ35_10840	COG0561	phosphatase activity
BIZ35_10855	COG2814	Major facilitator Superfamily
BIZ35_10860	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BIZ35_10885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BIZ35_10890	COG0667	Aldo Keto reductase
BIZ35_10895	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BIZ35_10900	COG1461	Dihydroxyacetone kinase
BIZ35_10905	COG2376	Dihydroxyacetone kinase
BIZ35_10915	COG0778	Nitroreductase
BIZ35_10920	COG1113	amino acid transport
BIZ35_10925	COG0730	response to heat
BIZ35_10935	COG2233	PERMEase
BIZ35_10955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BIZ35_10975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BIZ35_10980	COG1024	Enoyl-CoA hydratase
BIZ35_10990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BIZ35_10995	COG0511	ligase activity, forming carbon-carbon bonds
BIZ35_11000	COG0439	Biotin carboxylase
BIZ35_11005	COG1960	acyl-CoA dehydrogenase activity
BIZ35_11010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BIZ35_11030	COG1349	DNA-binding transcription factor activity
BIZ35_11040	COG2376	Dihydroxyacetone kinase
BIZ35_11050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BIZ35_11060	COG2271	Major facilitator Superfamily
BIZ35_11065	COG1250	3-hydroxyacyl-CoA dehydrogenase
BIZ35_11080	COG0698	ribose 5-phosphate isomerase
BIZ35_11085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BIZ35_11090	COG1494	fructose-1,6-bisphosphatase
BIZ35_11095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BIZ35_11100	COG3829	transcription factor binding
BIZ35_11105	COG0833	amino acid
BIZ35_11145	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BIZ35_11150	COG1140	nitrate reductase beta subunit
BIZ35_11160	COG2181	nitrate reductase activity
BIZ35_11165	COG2223	nitrite transmembrane transporter activity
BIZ35_11170	COG3588	fructose-bisphosphate aldolase
BIZ35_11175	COG1657	PFAM Prenyltransferase squalene oxidase
BIZ35_11180	COG1349	DNA-binding transcription factor activity
BIZ35_11220	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BIZ35_11245	COG1280	lysine exporter protein (LysE YggA)
BIZ35_11250	COG0386	Belongs to the glutathione peroxidase family
BIZ35_11255	COG2190	(PTS) system
BIZ35_11275	COG0582	viral genome integration into host DNA
BIZ35_11300	COG1328	CTP reductase activity
BIZ35_11310	COG1063	alcohol dehydrogenase
BIZ35_11315	COG1929	Belongs to the glycerate kinase type-1 family
BIZ35_11330	COG1879	ABC-type sugar transport system periplasmic component
BIZ35_11335	COG1172	Belongs to the binding-protein-dependent transport system permease family
BIZ35_11340	COG1129	ABC transporter
BIZ35_11345	COG1869	D-ribose catabolic process
BIZ35_11350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIZ35_11355	COG1609	Transcriptional regulator
BIZ35_11390	COG4549	nuclear export factor GLE1
BIZ35_11395	COG2372	response to copper ion
BIZ35_11395	COG1276	copper resistance
BIZ35_11405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BIZ35_11410	COG1609	Transcriptional regulator
BIZ35_11425	COG5002	protein histidine kinase activity
BIZ35_11430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BIZ35_11445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BIZ35_11455	COG2204	response regulator
BIZ35_11460	COG1606	tRNA processing
BIZ35_11465	COG2610	gluconate transmembrane transporter activity
BIZ35_11470	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BIZ35_11475	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BIZ35_11480	COG1691	(AIR) carboxylase
BIZ35_11500	COG1278	Cold shock
BIZ35_11515	COG0697	spore germination
BIZ35_11520	COG1472	Belongs to the glycosyl hydrolase 3 family
BIZ35_11530	COG3876	Protein conserved in bacteria
BIZ35_11545	COG1132	(ABC) transporter
BIZ35_11550	COG1132	(ABC) transporter
BIZ35_11560	COG1349	DNA-binding transcription factor activity
BIZ35_11565	COG1082	Xylose isomerase domain protein TIM barrel
BIZ35_11570	COG1082	Xylose isomerase domain protein TIM barrel
BIZ35_11575	COG0673	inositol 2-dehydrogenase activity
BIZ35_11580	COG2814	Major facilitator Superfamily
BIZ35_11585	COG1082	Xylose isomerase domain protein TIM barrel
BIZ35_11590	COG0673	inositol 2-dehydrogenase activity
BIZ35_11595	COG1082	Xylose isomerase domain protein TIM barrel
BIZ35_11600	COG0673	inositol 2-dehydrogenase activity
BIZ35_11605	COG1082	Xylose isomerase domain protein TIM barrel
BIZ35_11610	COG2814	Major facilitator Superfamily
BIZ35_11615	COG2814	Major facilitator Superfamily
BIZ35_11620	COG0191	fructose-bisphosphate aldolase activity
BIZ35_11625	COG3962	Belongs to the TPP enzyme family
BIZ35_11630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIZ35_11635	COG3718	enzyme involved in inositol metabolism
BIZ35_11640	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_11645	COG1388	LysM domain
BIZ35_11645	COG0791	NLP P60 protein
BIZ35_11665	COG2272	Belongs to the type-B carboxylesterase lipase family
BIZ35_11670	COG0154	amidase activity
BIZ35_11675	COG2814	Major facilitator Superfamily
BIZ35_11680	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_11705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BIZ35_11705	COG3153	acetyltransferase
BIZ35_11710	COG5583	Uncharacterized small protein (DUF2292)
BIZ35_11715	COG0431	NADPH-dependent FMN reductase
BIZ35_11720	COG1116	anion transmembrane transporter activity
BIZ35_11725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIZ35_11730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIZ35_11735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIZ35_11760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIZ35_11775	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BIZ35_11785	COG2390	Transcriptional regulator
BIZ35_11795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BIZ35_11805	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BIZ35_11820	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BIZ35_11825	COG1984	allophanate hydrolase subunit 2
BIZ35_11830	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BIZ35_11835	COG2814	Major facilitator Superfamily
BIZ35_11840	COG1764	response to oxidative stress
BIZ35_11845	COG1126	abc transporter atp-binding protein
BIZ35_11850	COG0765	amino acid transport
BIZ35_11855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIZ35_11865	COG0326	Molecular chaperone. Has ATPase activity
BIZ35_11885	COG0800	Aldolase
BIZ35_11900	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_11905	COG3716	PTS system mannose fructose sorbose family IID component
BIZ35_11915	COG0371	Dehydrogenase
BIZ35_11925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIZ35_11930	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BIZ35_11940	COG1737	Transcriptional regulator
BIZ35_11945	COG0561	phosphatase activity
BIZ35_11960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIZ35_11975	COG1064	alcohol dehydrogenase
BIZ35_12010	COG2814	Major facilitator Superfamily
BIZ35_12015	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_12060	COG3716	PTS system mannose fructose sorbose family IID component
BIZ35_12155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIZ35_12165	COG1597	lipid kinase activity
BIZ35_12190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BIZ35_12195	COG0154	amidase activity
BIZ35_12200	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BIZ35_12205	COG2224	Isocitrate lyase
BIZ35_12210	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BIZ35_12215	COG4851	CamS sex pheromone cAM373 precursor
BIZ35_12225	COG0210	DNA helicase
BIZ35_12230	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BIZ35_12235	COG4496	protein, YerC YecD
BIZ35_12240	COG1470	cell adhesion involved in biofilm formation
BIZ35_12255	COG0151	Belongs to the GarS family
BIZ35_12260	COG0138	bifunctional purine biosynthesis protein purh
BIZ35_12265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BIZ35_12270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BIZ35_12275	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BIZ35_12280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIZ35_12285	COG0047	phosphoribosylformylglycinamidine synthase activity
BIZ35_12290	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIZ35_12300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BIZ35_12305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BIZ35_12310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BIZ35_12320	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BIZ35_12325	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BIZ35_12345	COG1301	dicarboxylic acid transport
BIZ35_12355	COG3711	transcriptional antiterminator
BIZ35_12360	COG2252	PERMEase
BIZ35_12370	COG1132	(ABC) transporter
BIZ35_12375	COG2814	Major facilitator Superfamily
BIZ35_12380	COG2197	response regulator
BIZ35_12385	COG3850	Histidine kinase
BIZ35_12390	COG1131	(ABC) transporter
BIZ35_12400	COG0842	Transport permease protein
BIZ35_12420	COG0471	metal ion transport
BIZ35_12445	COG1131	(ABC) transporter
BIZ35_12450	COG1725	Transcriptional regulator
BIZ35_12455	COG1695	Transcriptional regulator
BIZ35_12460	COG3479	Phenolic acid decarboxylase
BIZ35_12465	COG2910	NAD(P)H-binding
BIZ35_12470	COG1959	2 iron, 2 sulfur cluster binding
BIZ35_12490	COG0425	Belongs to the sulfur carrier protein TusA family
BIZ35_12495	COG2391	methyltransferase activity
BIZ35_12505	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_12525	COG1120	ATPase activity
BIZ35_12530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIZ35_12550	COG3620	sequence-specific DNA binding
BIZ35_12565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BIZ35_12565	COG0519	Catalyzes the synthesis of GMP from XMP
BIZ35_12570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BIZ35_12575	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BIZ35_12580	COG1335	isochorismatase
BIZ35_12590	COG4948	Mandelate Racemase Muconate Lactonizing
BIZ35_12600	COG0463	Glycosyl transferase, family 2
BIZ35_12605	COG2246	polysaccharide biosynthetic process
BIZ35_12610	COG0459	protein refolding
BIZ35_12615	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BIZ35_12620	COG1266	CAAX protease self-immunity
BIZ35_12630	COG0805	protein transport
BIZ35_12635	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BIZ35_12640	COG0488	(ABC) transporter
BIZ35_12655	COG0456	acetyltransferase
BIZ35_12660	COG1214	PFAM Peptidase M22, glycoprotease
BIZ35_12665	COG0802	atpase or kinase
BIZ35_12750	COG3091	SprT-like family
BIZ35_12760	COG2183	response to ionizing radiation
BIZ35_12765	COG2208	phosphoserine phosphatase activity
BIZ35_12770	COG1191	sigma factor activity
BIZ35_12775	COG2172	sigma factor antagonist activity
BIZ35_12780	COG1366	Belongs to the anti-sigma-factor antagonist family
BIZ35_12785	COG2208	phosphoserine phosphatase activity
BIZ35_12790	COG2172	sigma factor antagonist activity
BIZ35_12795	COG1366	Belongs to the anti-sigma-factor antagonist family
BIZ35_12800	COG1366	Belongs to the anti-sigma-factor antagonist family
BIZ35_12810	COG2337	Toxic component of a toxin-antitoxin (TA) module
BIZ35_12815	COG0864	Transcriptional regulator
BIZ35_12825	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BIZ35_12830	COG0736	holo-[acyl-carrier-protein] synthase activity
BIZ35_12835	COG0705	Rhomboid family
BIZ35_12845	COG0513	Belongs to the DEAD box helicase family
BIZ35_12860	COG1280	lysine exporter protein (LysE YggA)
BIZ35_12870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BIZ35_12875	COG1609	Transcriptional regulator
BIZ35_12880	COG0366	Alpha amylase catalytic
BIZ35_12890	COG2182	Extracellular solute-binding protein
BIZ35_12895	COG1175	transmembrane transport
BIZ35_12900	COG3833	ABC-type maltose transport systems, permease component
BIZ35_12905	COG5521	maltodextrose utilization protein MalA
BIZ35_12910	COG1554	hydrolase, family 65, central catalytic
BIZ35_12920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BIZ35_12925	COG1181	Belongs to the D-alanine--D-alanine ligase family
BIZ35_12940	COG1253	flavin adenine dinucleotide binding
BIZ35_12945	COG0789	Transcriptional regulator
BIZ35_12950	COG1253	flavin adenine dinucleotide binding
BIZ35_12960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BIZ35_12975	COG0629	single-stranded DNA binding
BIZ35_12980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BIZ35_12985	COG4786	Flagellar basal body rod
BIZ35_12990	COG4786	Flagellar basal body rod
BIZ35_12995	COG1077	Cell shape determining protein MreB Mrl
BIZ35_13000	COG1609	Transcriptional regulator
BIZ35_13005	COG0739	heme binding
BIZ35_13010	COG2385	sporulation resulting in formation of a cellular spore
BIZ35_13020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIZ35_13030	COG4836	Membrane
BIZ35_13035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BIZ35_13040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BIZ35_13045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BIZ35_13050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BIZ35_13055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BIZ35_13065	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BIZ35_13070	COG0356	it plays a direct role in the translocation of protons across the membrane
BIZ35_13080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BIZ35_13085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BIZ35_13095	COG4475	Protein of unknown function (DUF436)
BIZ35_13100	COG0698	ribose 5-phosphate isomerase
BIZ35_13105	COG0840	transmembrane signaling receptor activity
BIZ35_13115	COG1971	Probably functions as a manganese efflux pump
BIZ35_13120	COG0009	L-threonylcarbamoyladenylate synthase
BIZ35_13135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BIZ35_13145	COG1435	thymidine kinase activity
BIZ35_13150	COG0254	rRNA binding
BIZ35_13155	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BIZ35_13160	COG1494	fructose-1,6-bisphosphatase
BIZ35_13165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIZ35_13170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BIZ35_13175	COG0191	fructose-bisphosphate aldolase activity
BIZ35_13180	COG2204	response regulator
BIZ35_13195	COG1131	(ABC) transporter
BIZ35_13200	COG1725	Transcriptional regulator
BIZ35_13205	COG0504	CTP synthase activity
BIZ35_13210	COG3343	RNA polymerase activity
BIZ35_13220	COG1136	(ABC) transporter
BIZ35_13235	COG1309	transcriptional regulator
BIZ35_13240	COG1960	acyl-CoA dehydrogenase activity
BIZ35_13245	COG1960	acyl-CoA dehydrogenase activity
BIZ35_13250	COG0183	Belongs to the thiolase family
BIZ35_13255	COG0247	lactate metabolic process
BIZ35_13255	COG2181	nitrate reductase activity
BIZ35_13260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BIZ35_13265	COG0018	arginyl-trna synthetase
BIZ35_13275	COG0010	Belongs to the arginase family
BIZ35_13280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIZ35_13290	COG1994	Peptidase M50
BIZ35_13300	COG3465	dGTPase activity
BIZ35_13305	COG1078	dGTPase activity
BIZ35_13320	COG0095	Lipoate-protein ligase
BIZ35_13325	COG0280	phosphate acetyltransferase
BIZ35_13330	COG3253	May function as heme-dependent peroxidase
BIZ35_13340	COG2363	Small membrane protein
BIZ35_13355	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BIZ35_13390	COG4555	ABC transporter
BIZ35_13405	COG1122	ATPase activity
BIZ35_13420	COG0351	phosphomethylpyrimidine kinase
BIZ35_13435	COG0561	phosphatase activity
BIZ35_13440	COG0514	ATP-dependent DNA helicase (RecQ)
BIZ35_13445	COG1785	Belongs to the alkaline phosphatase family
BIZ35_13450	COG1737	Transcriptional regulator
BIZ35_13460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BIZ35_13465	COG1346	cytolysis
BIZ35_13470	COG1380	Effector of murein hydrolase LrgA
BIZ35_13475	COG0583	DNA-binding transcription factor activity
BIZ35_13480	COG0367	asparagine synthase
BIZ35_13505	COG2966	Psort location CytoplasmicMembrane, score
BIZ35_13510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BIZ35_13515	COG1966	Carbon starvation protein
BIZ35_13525	COG3275	phosphorelay sensor kinase activity
BIZ35_13535	COG1464	Belongs to the NlpA lipoprotein family
BIZ35_13540	COG2011	ABC-type metal ion transport system permease component
BIZ35_13545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BIZ35_13550	COG1119	ATPase activity
BIZ35_13565	COG0534	Mate efflux family protein
BIZ35_13570	COG1442	glycosyl transferase family 8
BIZ35_13575	COG2195	Cleaves the N-terminal amino acid of tripeptides
BIZ35_13580	COG2814	Major facilitator Superfamily
BIZ35_13595	COG0028	Belongs to the TPP enzyme family
BIZ35_13615	COG3842	ATPase activity
BIZ35_13635	COG0584	glycerophosphoryl diester phosphodiesterase
BIZ35_13675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BIZ35_13695	COG2188	Transcriptional regulator
BIZ35_13700	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BIZ35_13705	COG1366	Belongs to the anti-sigma-factor antagonist family
BIZ35_13730	COG3457	Alanine racemase
BIZ35_13740	COG1126	abc transporter atp-binding protein
BIZ35_13750	COG0765	amino acid transport
BIZ35_13755	COG0579	oxidoreductase
BIZ35_13760	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BIZ35_13765	COG0732	type I restriction modification DNA specificity domain
BIZ35_13770	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BIZ35_13780	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BIZ35_13785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIZ35_13790	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BIZ35_13795	COG4853	Protein conserved in bacteria
BIZ35_13800	COG4863	YycH protein
BIZ35_13805	COG5002	protein histidine kinase activity
BIZ35_13810	COG0745	RESPONSE REGULATOR receiver
BIZ35_13825	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BIZ35_13830	COG0305	Participates in initiation and elongation during chromosome replication
BIZ35_13835	COG0359	binds to the 23S rRNA
BIZ35_13840	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BIZ35_13850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BIZ35_13855	COG0629	single-stranded DNA binding
BIZ35_13860	COG0360	Binds together with S18 to 16S ribosomal RNA
BIZ35_13865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BIZ35_13870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BIZ35_13870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BIZ35_13875	COG0307	riboflavin synthase, alpha
BIZ35_13880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BIZ35_13880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BIZ35_13885	COG0012	GTP binding
BIZ35_13890	COG4481	Protein conserved in bacteria
BIZ35_13895	COG0668	transmembrane transport
BIZ35_13910	COG1475	DNA binding
BIZ35_13915	COG1192	Involved in chromosome partitioning
BIZ35_13920	COG1475	DNA binding
BIZ35_13925	COG0357	Ribosomal RNA small subunit methyltransferase G
BIZ35_13930	COG0445	tRNA wobble uridine modification
BIZ35_13935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BIZ35_13940	COG1847	R3H domain protein
BIZ35_13945	COG0706	membrane insertase activity
BIZ35_13950	COG0594	ribonuclease P activity
BIZ35_13955	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BIZ35_13965	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BIZ35_13970	COG0592	DNA-directed DNA polymerase activity
BIZ35_13975	COG2501	S4 domain
BIZ35_13980	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BIZ35_13990	COG0187	DNA topoisomerase II activity
BIZ35_13995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BIZ35_14000	COG3437	response regulator, receiver
BIZ35_14035	COG1982	Orn Lys Arg decarboxylase major
BIZ35_14045	COG3870	Protein conserved in bacteria
BIZ35_14050	COG1728	Protein conserved in bacteria
BIZ35_14055	COG0470	DNA polymerase III
BIZ35_14060	COG1774	PSP1 C-terminal conserved region
BIZ35_14065	COG4467	Involved in initiation control of chromosome replication
BIZ35_14070	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BIZ35_14075	COG2827	Endonuclease containing a URI domain
BIZ35_14080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BIZ35_14085	COG2002	toxin-antitoxin pair type II binding
BIZ35_14095	COG0084	hydrolase, TatD family'
BIZ35_14105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BIZ35_14120	COG4466	Protein conserved in bacteria
BIZ35_14130	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BIZ35_14135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIZ35_14140	COG0251	oxidation-reduction process
BIZ35_14180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BIZ35_14185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BIZ35_14190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BIZ35_14195	COG0193	aminoacyl-tRNA hydrolase activity
BIZ35_14205	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BIZ35_14210	COG2002	toxin-antitoxin pair type II binding
BIZ35_14215	COG2244	polysaccharide biosynthetic process
BIZ35_14220	COG3956	TIGRFAM MazG family protein
BIZ35_14225	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BIZ35_14245	COG1098	S1 RNA binding domain
BIZ35_14255	COG2208	phosphoserine phosphatase activity
BIZ35_14260	COG2304	oxidoreductase activity
BIZ35_14265	COG0515	serine threonine protein kinase
BIZ35_14270	COG0037	tRNA processing
BIZ35_14275	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BIZ35_14280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BIZ35_14285	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BIZ35_14290	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BIZ35_14295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BIZ35_14300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BIZ35_14305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BIZ35_14310	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BIZ35_14390	COG0516	GMP reductase activity
BIZ35_14390	COG0517	IMP dehydrogenase activity
BIZ35_14405	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BIZ35_14415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BIZ35_14430	COG1428	Deoxynucleoside kinase
BIZ35_14435	COG1428	Deoxynucleoside kinase
BIZ35_14450	COG0590	tRNA wobble adenosine to inosine editing
BIZ35_14460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BIZ35_14465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BIZ35_14470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BIZ35_14525	COG3880	PFAM UvrB UvrC protein
BIZ35_14530	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BIZ35_14535	COG0542	response to heat
BIZ35_14540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BIZ35_14545	COG4956	integral membrane protein (PIN domain superfamily)
BIZ35_14555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BIZ35_14560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BIZ35_14565	COG1045	serine acetyltransferase
BIZ35_14570	COG0215	cysteine-tRNA ligase activity
BIZ35_14580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIZ35_14585	COG3688	RNA-binding protein containing a PIN domain
BIZ35_14595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BIZ35_14600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BIZ35_14605	COG0250	Participates in transcription elongation, termination and antitermination
BIZ35_14610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BIZ35_14615	COG0081	regulation of translation
BIZ35_14620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BIZ35_14630	COG2813	Specifically methylates the guanine in position
BIZ35_14635	COG0085	RNA polymerase activity
BIZ35_14645	COG1358	cellular component organization or biogenesis
BIZ35_14650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BIZ35_14655	COG0049	tRNA binding
BIZ35_14660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BIZ35_14665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BIZ35_14680	COG0051	transcription antitermination factor activity, RNA binding
BIZ35_14700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BIZ35_14705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BIZ35_14715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BIZ35_14720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BIZ35_14725	COG0255	Belongs to the universal ribosomal protein uL29 family
BIZ35_14730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BIZ35_14735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BIZ35_14740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BIZ35_14750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BIZ35_14755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BIZ35_14760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BIZ35_14765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BIZ35_14770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BIZ35_14780	COG0200	Binds to the 23S rRNA
BIZ35_14785	COG0201	protein transport
BIZ35_14790	COG0563	adenylate kinase activity
BIZ35_14795	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BIZ35_14800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BIZ35_14805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BIZ35_14810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BIZ35_14815	COG0202	RNA polymerase activity
BIZ35_14820	COG0203	ribosomal protein L17
BIZ35_14825	COG1122	ATPase activity
BIZ35_14830	COG1122	ATPase activity
BIZ35_14835	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BIZ35_14845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BIZ35_14850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BIZ35_14855	COG0753	catalase activity
BIZ35_14870	COG2046	Belongs to the sulfate adenylyltransferase family
BIZ35_14875	COG0529	Catalyzes the synthesis of activated sulfate
BIZ35_14880	COG0833	amino acid
BIZ35_14890	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIZ35_14895	COG0489	protein tyrosine kinase activity
BIZ35_14910	COG2194	sulfuric ester hydrolase activity
BIZ35_14940	COG0662	Cupin 2, conserved barrel domain protein
BIZ35_14950	COG0726	polysaccharide deacetylase
BIZ35_14960	COG1271	oxidase subunit
BIZ35_14965	COG1294	oxidase, subunit
BIZ35_14970	COG4988	ABC transporter
BIZ35_14975	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BIZ35_15050	COG1525	nuclease
BIZ35_15065	COG3620	sequence-specific DNA binding
BIZ35_15110	COG5377	YqaJ viral recombinase family
BIZ35_15115	COG3723	Recombinational DNA repair protein, rece pathway
BIZ35_15180	COG4566	intracellular signal transduction
BIZ35_15310	COG3942	CHAP domain
BIZ35_15310	COG1388	LysM domain
BIZ35_15335	COG1595	DNA-templated transcription, initiation
BIZ35_15340	COG5662	AntiSigma factor
BIZ35_15345	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BIZ35_15350	COG4856	YbbR-like protein
BIZ35_15355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BIZ35_15360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BIZ35_15385	COG2814	Major facilitator Superfamily
BIZ35_15405	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BIZ35_15410	COG0840	transmembrane signaling receptor activity
BIZ35_15425	COG1695	Transcriptional regulator
BIZ35_15435	COG0840	transmembrane signaling receptor activity
BIZ35_15440	COG0477	Major facilitator Superfamily
BIZ35_15495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIZ35_15500	COG2814	Major facilitator Superfamily
BIZ35_15515	COG0519	Catalyzes the synthesis of GMP from XMP
BIZ35_15540	COG2814	Major facilitator Superfamily
BIZ35_15540	COG0477	Major facilitator Superfamily
BIZ35_15575	COG3425	synthase
BIZ35_15580	COG0183	Belongs to the thiolase family
BIZ35_15605	COG0517	IMP dehydrogenase activity
BIZ35_15605	COG1125	glycine betaine transport
BIZ35_15610	COG1174	glycine betaine transport
BIZ35_15615	COG2190	(PTS) system
BIZ35_15620	COG1263	PTS System
BIZ35_15620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_15625	COG0366	Alpha amylase catalytic
BIZ35_15630	COG2188	Transcriptional regulator
BIZ35_15640	COG1070	Carbohydrate kinase
BIZ35_15650	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BIZ35_15655	COG0716	FMN binding
BIZ35_15660	COG0322	excinuclease ABC activity
BIZ35_15665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIZ35_15675	COG2608	mercury ion transmembrane transporter activity
BIZ35_15680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIZ35_15690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIZ35_15695	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BIZ35_15700	COG0463	Glycosyl transferase, family 2
BIZ35_15730	COG2076	Multidrug Resistance protein
BIZ35_15735	COG2076	Multidrug Resistance protein
BIZ35_15745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIZ35_15750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIZ35_15755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIZ35_15765	COG1120	ATPase activity
BIZ35_15795	COG0217	transcriptional regulatory protein
BIZ35_15800	COG1366	Belongs to the anti-sigma-factor antagonist family
BIZ35_15810	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_15820	COG1309	transcriptional regulator
BIZ35_15835	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_15845	COG0765	amino acid transport
BIZ35_15855	COG5434	Belongs to the glycosyl hydrolase 28 family
BIZ35_15860	COG0175	sulfate reduction
BIZ35_15880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BIZ35_15885	COG0371	Dehydrogenase
BIZ35_15890	COG0318	PFAM AMP-dependent synthetase and ligase
BIZ35_15905	COG0697	spore germination
BIZ35_15925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BIZ35_15940	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BIZ35_15965	COG0702	epimerase
BIZ35_15985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_15985	COG2213	PTS system mannitol-specific
BIZ35_15990	COG3711	transcriptional antiterminator
BIZ35_15995	COG0246	Mannitol dehydrogenase
BIZ35_16000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BIZ35_16020	COG2848	UPF0210 protein
BIZ35_16025	COG1609	Transcriptional regulator
BIZ35_16040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIZ35_16055	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BIZ35_16065	COG5577	PFAM Coat F domain
BIZ35_16075	COG0667	Aldo Keto reductase
BIZ35_16085	COG1113	amino acid transport
BIZ35_16090	COG3104	oligopeptide transport
BIZ35_16095	COG0833	amino acid
BIZ35_16115	COG3842	ATPase activity
BIZ35_16120	COG1176	ABC-type spermidine putrescine transport system, permease component I
BIZ35_16145	COG0531	amino acid
BIZ35_16150	COG1556	Lactate utilization protein
BIZ35_16155	COG1139	Iron-sulfur cluster binding protein
BIZ35_16160	COG0247	lactate metabolic process
BIZ35_16170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BIZ35_16175	COG1454	alcohol dehydrogenase
BIZ35_16185	COG1953	Uracil, thiamine, allantoin
BIZ35_16210	COG0531	amino acid
BIZ35_16215	COG1979	alcohol dehydrogenase
BIZ35_16220	COG0004	ammonium transporteR
BIZ35_16225	COG3290	protein histidine kinase activity
BIZ35_16230	COG4565	transcriptional regulatory protein
BIZ35_16235	COG2851	Citrate transporter
BIZ35_16240	COG0463	Glycosyl transferase, family 2
BIZ35_16245	COG3973	AAA domain
BIZ35_16275	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BIZ35_16280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BIZ35_16285	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BIZ35_16295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BIZ35_16300	COG1301	dicarboxylic acid transport
BIZ35_16305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIZ35_16335	COG1902	pentaerythritol trinitrate reductase activity
BIZ35_16355	COG0423	glycine-tRNA ligase activity
BIZ35_16360	COG0531	amino acid
BIZ35_16370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BIZ35_16380	COG0628	permease
BIZ35_16395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIZ35_16400	COG0765	amino acid transport
BIZ35_16405	COG0765	amino acid transport
BIZ35_16420	COG1733	regulation of RNA biosynthetic process
BIZ35_16435	COG0586	Pfam SNARE associated Golgi protein
BIZ35_16440	COG0586	Pfam SNARE associated Golgi protein
BIZ35_16460	COG0646	methionine synthase
BIZ35_16460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BIZ35_16465	COG1410	methionine synthase
BIZ35_16465	COG0646	methionine synthase
BIZ35_16495	COG3944	biosynthesis protein
BIZ35_16500	COG0489	protein tyrosine kinase activity
BIZ35_16505	COG4464	protein tyrosine phosphatase activity
BIZ35_16510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BIZ35_16525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BIZ35_16560	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BIZ35_16560	COG0662	Cupin 2, conserved barrel domain protein
BIZ35_16565	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BIZ35_16595	COG1070	Carbohydrate kinase
BIZ35_16620	COG4193	domain, Protein
BIZ35_16635	COG5504	Zn-dependent protease
BIZ35_16640	COG2226	methyltransferase
BIZ35_16680	COG3716	PTS system mannose fructose sorbose family IID component
BIZ35_16685	COG3715	PTS system
BIZ35_16690	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_16695	COG0363	glucosamine-6-phosphate deaminase activity
BIZ35_16700	COG2188	Transcriptional regulator
BIZ35_16705	COG1396	sequence-specific DNA binding
BIZ35_16715	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
BIZ35_16720	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BIZ35_16725	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BIZ35_16725	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BIZ35_16735	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_16735	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_16740	COG3715	PTS system
BIZ35_16745	COG3716	PTS system mannose fructose sorbose family IID component
BIZ35_16765	COG3414	Phosphotransferase system galactitol-specific IIB component
BIZ35_16770	COG3775	system Galactitol-specific IIC component
BIZ35_16780	COG1105	Belongs to the carbohydrate kinase PfkB family
BIZ35_16785	COG0235	Class ii aldolase
BIZ35_16805	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BIZ35_16815	COG0145	ligase activity
BIZ35_16825	COG2315	Protein conserved in bacteria
BIZ35_16835	COG0658	competence protein
BIZ35_16835	COG2333	competence protein COMEC
BIZ35_16860	COG0531	amino acid
BIZ35_16870	COG1316	TRANSCRIPTIONal
BIZ35_16880	COG4989	oxidoreductase activity
BIZ35_16905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BIZ35_16910	COG2130	NADP-dependent
BIZ35_16925	COG3711	transcriptional antiterminator
BIZ35_16925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_16930	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ35_16935	COG1447	Phosphotransferase system cellobiose-specific component IIA
BIZ35_16945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ35_16965	COG2814	Major facilitator Superfamily
BIZ35_16975	COG1609	Transcriptional regulator
BIZ35_16990	COG1174	glycine betaine transport
BIZ35_16995	COG1732	Glycine betaine
BIZ35_17000	COG1174	glycine betaine transport
BIZ35_17005	COG1125	glycine betaine transport
BIZ35_17005	COG0517	IMP dehydrogenase activity
BIZ35_17010	COG1510	regulation of RNA biosynthetic process
BIZ35_17015	COG0110	maltose O-acetyltransferase activity
BIZ35_17030	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_17045	COG4297	protein containing double-stranded beta helix domain
BIZ35_17055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIZ35_17070	COG0606	chelatase, subunit chli
BIZ35_17080	COG0371	Dehydrogenase
BIZ35_17085	COG2814	Major facilitator Superfamily
BIZ35_17090	COG1070	Carbohydrate kinase
BIZ35_17095	COG2115	Belongs to the xylose isomerase family
BIZ35_17110	COG0157	Belongs to the NadC ModD family
BIZ35_17115	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BIZ35_17120	COG1104	cysteine desulfurase activity
BIZ35_17130	COG2116	formate transmembrane transporter activity
BIZ35_17150	COG4720	Psort location CytoplasmicMembrane, score
BIZ35_17160	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_17165	COG2610	gluconate transmembrane transporter activity
BIZ35_17170	COG1012	belongs to the aldehyde dehydrogenase family
BIZ35_17180	COG3829	transcription factor binding
BIZ35_17180	COG3290	protein histidine kinase activity
BIZ35_17200	COG1960	acyl-CoA dehydrogenase activity
BIZ35_17235	COG3344	reverse transcriptase
BIZ35_17240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIZ35_17245	COG0737	Belongs to the 5'-nucleotidase family
BIZ35_17250	COG1363	Peptidase, m42
BIZ35_17295	COG2972	Histidine kinase
BIZ35_17315	COG0531	amino acid
BIZ35_17325	COG1620	l-lactate permease
BIZ35_17330	COG2186	Transcriptional regulator
BIZ35_17375	COG0473	3-isopropylmalate dehydrogenase activity
BIZ35_17405	COG1447	Phosphotransferase system cellobiose-specific component IIA
BIZ35_17420	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ35_17420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIZ35_17425	COG2723	6-phospho-beta-galactosidase activity
BIZ35_17430	COG3711	transcriptional antiterminator
BIZ35_17430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_17435	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BIZ35_17445	COG1131	(ABC) transporter
BIZ35_17455	COG0626	cystathionine gamma-synthase activity
BIZ35_17460	COG0626	cystathionine gamma-synthase activity
BIZ35_17480	COG1653	transport
BIZ35_17485	COG2207	Transcriptional regulator
BIZ35_17500	COG0604	alcohol dehydrogenase
BIZ35_17505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BIZ35_17510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BIZ35_17530	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ35_17535	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BIZ35_17545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BIZ35_17555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BIZ35_17560	COG1316	TRANSCRIPTIONal
BIZ35_17575	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BIZ35_17585	COG3584	3D domain protein
BIZ35_17585	COG1388	LysM domain
BIZ35_17595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BIZ35_17605	COG0011	TIGRFAM Protein of
BIZ35_17610	COG2706	6-phosphogluconolactonase activity
BIZ35_17625	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BIZ35_17625	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BIZ35_17630	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIZ35_17630	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ35_17640	COG3715	PTS system
BIZ35_17645	COG3716	PTS system mannose fructose sorbose family IID component