locus-tag	class	description
IR208_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IR208_00010	COG0592	DNA-directed DNA polymerase activity
IR208_00015	COG2501	S4 domain
IR208_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IR208_00030	COG0187	DNA topoisomerase II activity
IR208_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IR208_00040	COG3437	response regulator, receiver
IR208_00075	COG1982	Orn Lys Arg decarboxylase major
IR208_00085	COG3870	Protein conserved in bacteria
IR208_00090	COG1728	Protein conserved in bacteria
IR208_00095	COG0470	DNA polymerase III
IR208_00100	COG1774	PSP1 C-terminal conserved region
IR208_00105	COG4467	Involved in initiation control of chromosome replication
IR208_00110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IR208_00115	COG2827	Endonuclease containing a URI domain
IR208_00120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IR208_00125	COG2002	toxin-antitoxin pair type II binding
IR208_00135	COG0084	hydrolase, TatD family'
IR208_00145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IR208_00155	COG4466	Protein conserved in bacteria
IR208_00165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IR208_00170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IR208_00175	COG0251	oxidation-reduction process
IR208_00215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IR208_00220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IR208_00225	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IR208_00230	COG0193	aminoacyl-tRNA hydrolase activity
IR208_00240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IR208_00245	COG2002	toxin-antitoxin pair type II binding
IR208_00250	COG2244	polysaccharide biosynthetic process
IR208_00255	COG3956	TIGRFAM MazG family protein
IR208_00260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IR208_00280	COG1098	S1 RNA binding domain
IR208_00290	COG2208	phosphoserine phosphatase activity
IR208_00295	COG2304	oxidoreductase activity
IR208_00300	COG0515	serine threonine protein kinase
IR208_00305	COG0037	tRNA processing
IR208_00310	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IR208_00315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IR208_00320	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IR208_00325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IR208_00330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IR208_00335	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IR208_00340	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IR208_00345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IR208_00425	COG0516	GMP reductase activity
IR208_00425	COG0517	IMP dehydrogenase activity
IR208_00440	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IR208_00445	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IR208_00460	COG1428	Deoxynucleoside kinase
IR208_00465	COG1428	Deoxynucleoside kinase
IR208_00470	COG1388	LysM domain
IR208_00470	COG3858	chitin binding
IR208_00480	COG0590	tRNA wobble adenosine to inosine editing
IR208_00490	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IR208_00495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IR208_00500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IR208_00550	COG3880	PFAM UvrB UvrC protein
IR208_00555	COG3869	Catalyzes the specific phosphorylation of arginine residues in
IR208_00560	COG0542	response to heat
IR208_00565	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IR208_00570	COG4956	integral membrane protein (PIN domain superfamily)
IR208_00580	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IR208_00585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IR208_00590	COG1045	serine acetyltransferase
IR208_00595	COG0215	cysteine-tRNA ligase activity
IR208_00605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IR208_00610	COG3688	RNA-binding protein containing a PIN domain
IR208_00620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IR208_00625	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IR208_00630	COG0250	Participates in transcription elongation, termination and antitermination
IR208_00635	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IR208_00640	COG0081	regulation of translation
IR208_00645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IR208_00655	COG2813	Specifically methylates the guanine in position
IR208_00660	COG0085	RNA polymerase activity
IR208_00670	COG1358	cellular component organization or biogenesis
IR208_00675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IR208_00680	COG0049	tRNA binding
IR208_00685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IR208_00690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IR208_00700	COG0051	transcription antitermination factor activity, RNA binding
IR208_00720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IR208_00725	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IR208_00735	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IR208_00740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IR208_00745	COG0255	Belongs to the universal ribosomal protein uL29 family
IR208_00750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IR208_00755	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IR208_00760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IR208_00770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IR208_00775	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IR208_00780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IR208_00785	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IR208_00790	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IR208_00800	COG0200	Binds to the 23S rRNA
IR208_00805	COG0201	protein transport
IR208_00810	COG0563	adenylate kinase activity
IR208_00815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IR208_00820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IR208_00825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IR208_00830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IR208_00835	COG0202	RNA polymerase activity
IR208_00840	COG0203	ribosomal protein L17
IR208_00845	COG1122	ATPase activity
IR208_00850	COG1122	ATPase activity
IR208_00855	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IR208_00865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IR208_00870	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IR208_00875	COG0753	catalase activity
IR208_00885	COG2046	Belongs to the sulfate adenylyltransferase family
IR208_00890	COG0529	Catalyzes the synthesis of activated sulfate
IR208_00895	COG0833	amino acid
IR208_00905	COG0860	N-Acetylmuramoyl-L-alanine amidase
IR208_00910	COG0489	protein tyrosine kinase activity
IR208_00920	COG2194	sulfuric ester hydrolase activity
IR208_00945	COG0662	Cupin 2, conserved barrel domain protein
IR208_00955	COG0726	polysaccharide deacetylase
IR208_00965	COG1271	oxidase subunit
IR208_00970	COG1294	oxidase, subunit
IR208_00975	COG4988	ABC transporter
IR208_00980	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IR208_01055	COG1595	DNA-templated transcription, initiation
IR208_01060	COG5662	AntiSigma factor
IR208_01065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IR208_01070	COG4856	YbbR-like protein
IR208_01075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IR208_01080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IR208_01105	COG2814	Major facilitator Superfamily
IR208_01125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IR208_01130	COG0840	transmembrane signaling receptor activity
IR208_01145	COG1695	Transcriptional regulator
IR208_01150	COG0840	transmembrane signaling receptor activity
IR208_01155	COG0477	Major facilitator Superfamily
IR208_01205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IR208_01210	COG2814	Major facilitator Superfamily
IR208_01220	COG0519	Catalyzes the synthesis of GMP from XMP
IR208_01245	COG2814	Major facilitator Superfamily
IR208_01245	COG0477	Major facilitator Superfamily
IR208_01280	COG3425	synthase
IR208_01285	COG0183	Belongs to the thiolase family
IR208_01290	COG0183	Belongs to the thiolase family
IR208_01310	COG1125	glycine betaine transport
IR208_01310	COG0517	IMP dehydrogenase activity
IR208_01315	COG1174	glycine betaine transport
IR208_01320	COG2190	(PTS) system
IR208_01325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_01325	COG1263	PTS System
IR208_01330	COG0366	Alpha amylase catalytic
IR208_01335	COG2188	Transcriptional regulator
IR208_01345	COG1070	Carbohydrate kinase
IR208_01355	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IR208_01360	COG0716	FMN binding
IR208_01365	COG0322	excinuclease ABC activity
IR208_01375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IR208_01385	COG2608	mercury ion transmembrane transporter activity
IR208_01390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IR208_01400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IR208_01405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IR208_01410	COG0463	Glycosyl transferase, family 2
IR208_01440	COG2076	Multidrug Resistance protein
IR208_01445	COG2076	Multidrug Resistance protein
IR208_01455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR208_01460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR208_01465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IR208_01470	COG1120	ATPase activity
IR208_01495	COG0217	transcriptional regulatory protein
IR208_01500	COG1366	Belongs to the anti-sigma-factor antagonist family
IR208_01510	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_01520	COG1309	transcriptional regulator
IR208_01535	COG1012	belongs to the aldehyde dehydrogenase family
IR208_01545	COG0765	amino acid transport
IR208_01555	COG5434	Belongs to the glycosyl hydrolase 28 family
IR208_01560	COG0175	sulfate reduction
IR208_01580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IR208_01585	COG0371	Dehydrogenase
IR208_01590	COG0318	PFAM AMP-dependent synthetase and ligase
IR208_01605	COG0697	spore germination
IR208_01625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IR208_01635	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IR208_01650	COG0702	epimerase
IR208_01670	COG2213	PTS system mannitol-specific
IR208_01670	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_01675	COG3711	transcriptional antiterminator
IR208_01680	COG0246	Mannitol dehydrogenase
IR208_01685	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IR208_01705	COG2848	UPF0210 protein
IR208_01710	COG1609	Transcriptional regulator
IR208_01725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR208_01740	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IR208_01750	COG5577	PFAM Coat F domain
IR208_01760	COG0667	Aldo Keto reductase
IR208_01770	COG1113	amino acid transport
IR208_01775	COG3104	oligopeptide transport
IR208_01780	COG0833	amino acid
IR208_01790	COG3842	ATPase activity
IR208_01795	COG1176	ABC-type spermidine putrescine transport system, permease component I
IR208_01815	COG0531	amino acid
IR208_01820	COG1556	Lactate utilization protein
IR208_01825	COG1139	Iron-sulfur cluster binding protein
IR208_01830	COG0247	lactate metabolic process
IR208_01840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IR208_01845	COG1454	alcohol dehydrogenase
IR208_01855	COG1953	Uracil, thiamine, allantoin
IR208_01880	COG0531	amino acid
IR208_01885	COG1979	alcohol dehydrogenase
IR208_01890	COG0004	ammonium transporteR
IR208_01895	COG3290	protein histidine kinase activity
IR208_01900	COG4565	transcriptional regulatory protein
IR208_01905	COG2851	Citrate transporter
IR208_01910	COG0463	Glycosyl transferase, family 2
IR208_01915	COG3973	AAA domain
IR208_01940	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IR208_01945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IR208_01950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IR208_01955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IR208_01960	COG1301	dicarboxylic acid transport
IR208_01965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IR208_01980	COG1902	pentaerythritol trinitrate reductase activity
IR208_02000	COG0423	glycine-tRNA ligase activity
IR208_02005	COG0531	amino acid
IR208_02015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IR208_02020	COG0628	permease
IR208_02035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR208_02040	COG0765	amino acid transport
IR208_02045	COG0765	amino acid transport
IR208_02060	COG1733	regulation of RNA biosynthetic process
IR208_02070	COG0586	Pfam SNARE associated Golgi protein
IR208_02075	COG0586	Pfam SNARE associated Golgi protein
IR208_02090	COG0646	methionine synthase
IR208_02090	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IR208_02095	COG1410	methionine synthase
IR208_02095	COG0646	methionine synthase
IR208_02120	COG3944	biosynthesis protein
IR208_02125	COG0489	protein tyrosine kinase activity
IR208_02130	COG4464	protein tyrosine phosphatase activity
IR208_02135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IR208_02150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IR208_02185	COG0662	Cupin 2, conserved barrel domain protein
IR208_02185	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IR208_02190	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IR208_02220	COG1070	Carbohydrate kinase
IR208_02250	COG4193	domain, Protein
IR208_02270	COG5504	Zn-dependent protease
IR208_02275	COG2226	methyltransferase
IR208_02310	COG3716	PTS system mannose fructose sorbose family IID component
IR208_02315	COG3715	PTS system
IR208_02320	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_02325	COG0363	glucosamine-6-phosphate deaminase activity
IR208_02330	COG2188	Transcriptional regulator
IR208_02335	COG1396	sequence-specific DNA binding
IR208_02345	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
IR208_02350	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IR208_02355	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IR208_02355	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IR208_02365	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_02365	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_02370	COG3715	PTS system
IR208_02375	COG3716	PTS system mannose fructose sorbose family IID component
IR208_02395	COG3414	Phosphotransferase system galactitol-specific IIB component
IR208_02400	COG3775	system Galactitol-specific IIC component
IR208_02410	COG1105	Belongs to the carbohydrate kinase PfkB family
IR208_02415	COG0235	Class ii aldolase
IR208_02435	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IR208_02445	COG0145	ligase activity
IR208_02455	COG2315	Protein conserved in bacteria
IR208_02465	COG0658	competence protein
IR208_02465	COG2333	competence protein COMEC
IR208_02490	COG0531	amino acid
IR208_02500	COG1316	TRANSCRIPTIONal
IR208_02510	COG4989	oxidoreductase activity
IR208_02535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IR208_02540	COG2130	NADP-dependent
IR208_02550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_02550	COG3711	transcriptional antiterminator
IR208_02555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IR208_02560	COG1447	Phosphotransferase system cellobiose-specific component IIA
IR208_02570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IR208_02595	COG2814	Major facilitator Superfamily
IR208_02605	COG1609	Transcriptional regulator
IR208_02615	COG1174	glycine betaine transport
IR208_02620	COG1732	Glycine betaine
IR208_02625	COG1174	glycine betaine transport
IR208_02630	COG0517	IMP dehydrogenase activity
IR208_02630	COG1125	glycine betaine transport
IR208_02635	COG1510	regulation of RNA biosynthetic process
IR208_02640	COG0110	maltose O-acetyltransferase activity
IR208_02670	COG4297	protein containing double-stranded beta helix domain
IR208_02680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR208_02690	COG0606	chelatase, subunit chli
IR208_02705	COG0371	Dehydrogenase
IR208_02710	COG2814	Major facilitator Superfamily
IR208_02715	COG1070	Carbohydrate kinase
IR208_02720	COG2115	Belongs to the xylose isomerase family
IR208_02735	COG0157	Belongs to the NadC ModD family
IR208_02740	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IR208_02745	COG1104	cysteine desulfurase activity
IR208_02755	COG2116	formate transmembrane transporter activity
IR208_02775	COG4720	Psort location CytoplasmicMembrane, score
IR208_02785	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_02790	COG2610	gluconate transmembrane transporter activity
IR208_02795	COG1012	belongs to the aldehyde dehydrogenase family
IR208_02805	COG3829	transcription factor binding
IR208_02805	COG3290	protein histidine kinase activity
IR208_02820	COG1960	acyl-CoA dehydrogenase activity
IR208_02850	COG3344	reverse transcriptase
IR208_02855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR208_02860	COG0737	Belongs to the 5'-nucleotidase family
IR208_02865	COG1363	Peptidase, m42
IR208_02905	COG2972	Histidine kinase
IR208_02925	COG0531	amino acid
IR208_02935	COG1620	l-lactate permease
IR208_02940	COG2186	Transcriptional regulator
IR208_02970	COG0473	3-isopropylmalate dehydrogenase activity
IR208_03005	COG1447	Phosphotransferase system cellobiose-specific component IIA
IR208_03020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IR208_03020	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IR208_03025	COG2723	6-phospho-beta-galactosidase activity
IR208_03030	COG3711	transcriptional antiterminator
IR208_03030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_03035	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IR208_03045	COG1131	(ABC) transporter
IR208_03055	COG0626	cystathionine gamma-synthase activity
IR208_03060	COG0626	cystathionine gamma-synthase activity
IR208_03080	COG1653	transport
IR208_03085	COG2207	Transcriptional regulator
IR208_03100	COG0604	alcohol dehydrogenase
IR208_03105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IR208_03110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IR208_03130	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_03135	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IR208_03145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IR208_03155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IR208_03160	COG1316	TRANSCRIPTIONal
IR208_03175	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IR208_03185	COG3584	3D domain protein
IR208_03185	COG1388	LysM domain
IR208_03195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IR208_03205	COG0011	TIGRFAM Protein of
IR208_03210	COG2706	6-phosphogluconolactonase activity
IR208_03220	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IR208_03220	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IR208_03225	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_03225	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_03235	COG3715	PTS system
IR208_03240	COG3716	PTS system mannose fructose sorbose family IID component
IR208_03255	COG2079	MmgE PrpD family protein
IR208_03260	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IR208_03270	COG0154	amidase activity
IR208_03280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR208_03285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IR208_03290	COG1116	anion transmembrane transporter activity
IR208_03295	COG0083	homoserine kinase activity
IR208_03300	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IR208_03305	COG0460	homoserine dehydrogenase
IR208_03310	COG0010	Belongs to the arginase family
IR208_03320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IR208_03325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IR208_03335	COG4145	pantothenate transmembrane transporter activity
IR208_03350	COG1012	belongs to the aldehyde dehydrogenase family
IR208_03350	COG1454	alcohol dehydrogenase
IR208_03365	COG1388	LysM domain
IR208_03365	COG0791	NLP P60 protein
IR208_03370	COG0024	Methionine aminopeptidase
IR208_03375	COG1268	BioY protein
IR208_03390	COG1960	acyl-CoA dehydrogenase activity
IR208_03395	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_03400	COG2746	aminoglycoside 3-N-acetyltransferase activity
IR208_03405	COG2244	polysaccharide biosynthetic process
IR208_03410	COG0589	response to stress
IR208_03425	COG0535	radical SAM domain protein
IR208_03430	COG0457	Tetratricopeptide repeat
IR208_03445	COG1609	Transcriptional regulator
IR208_03455	COG0561	phosphatase activity
IR208_03490	COG0656	L-ascorbic acid biosynthetic process
IR208_03495	COG0431	NADPH-dependent FMN reductase
IR208_03500	COG0420	3'-5' exonuclease activity
IR208_03505	COG4717	serine-type aminopeptidase activity
IR208_03510	COG1250	3-hydroxyacyl-CoA dehydrogenase
IR208_03515	COG0534	Mate efflux family protein
IR208_03520	COG1664	Polymer-forming cytoskeletal
IR208_03530	COG0789	Transcriptional regulator
IR208_03535	COG0436	Aminotransferase
IR208_03540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IR208_03560	COG2226	methyltransferase
IR208_03580	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IR208_03605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IR208_03610	COG1113	amino acid transport
IR208_03615	COG2814	Major facilitator Superfamily
IR208_03630	COG1033	growth of symbiont in host cell
IR208_03630	COG2409	Drug exporters of the RND superfamily
IR208_03640	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IR208_03655	COG1960	acyl-CoA dehydrogenase activity
IR208_03670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IR208_03675	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
IR208_03685	COG1609	Transcriptional regulator
IR208_03700	COG2996	Protein conserved in bacteria
IR208_03705	COG0346	lactoylglutathione lyase activity
IR208_03710	COG1482	cell wall glycoprotein biosynthetic process
IR208_03720	COG0477	Major facilitator Superfamily
IR208_03725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IR208_03735	COG2188	Transcriptional regulator
IR208_03740	COG1388	LysM domain
IR208_03740	COG0791	NLP P60 protein
IR208_03750	COG0768	penicillin binding
IR208_03755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IR208_03760	COG1739	Uncharacterized protein family UPF0029
IR208_03770	COG2197	response regulator
IR208_03775	COG0531	amino acid
IR208_03780	COG1307	EDD domain protein, DegV family
IR208_03785	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IR208_03790	COG1040	competence protein
IR208_03800	COG2747	anti-sigma28 factor FlgM
IR208_03810	COG4786	Flagellar basal body rod
IR208_03810	COG1256	bacterial-type flagellum assembly
IR208_03815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IR208_03825	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IR208_03845	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IR208_03850	COG1285	pathogenesis
IR208_03855	COG0647	UMP catabolic process
IR208_03865	COG2271	Major facilitator Superfamily
IR208_03870	COG1113	amino acid transport
IR208_03880	COG1113	amino acid transport
IR208_03885	COG1067	ATP-dependent peptidase activity
IR208_03895	COG2094	Belongs to the DNA glycosylase MPG family
IR208_03905	COG1334	flagellar protein FlaG
IR208_03910	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IR208_03915	COG1516	flagellar protein fliS
IR208_03935	COG0653	protein targeting
IR208_03945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IR208_03955	COG2884	Cell division ATP-binding protein ftsE
IR208_03960	COG2177	Part of the ABC transporter FtsEX involved in
IR208_03965	COG0739	heme binding
IR208_03980	COG0460	homoserine dehydrogenase
IR208_03985	COG0793	Belongs to the peptidase S41A family
IR208_03985	COG3409	Peptidoglycan-binding domain 1 protein
IR208_03995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IR208_04000	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR208_04005	COG4605	iron ion homeostasis
IR208_04010	COG4604	ABC transporter, ATP-binding protein
IR208_04015	COG4607	ABC-type enterochelin transport system periplasmic component
IR208_04030	COG0745	RESPONSE REGULATOR receiver
IR208_04035	COG5002	protein histidine kinase activity
IR208_04040	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IR208_04055	COG0573	inorganic phosphate transmembrane transporter activity
IR208_04060	COG0581	inorganic phosphate transmembrane transporter activity
IR208_04070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IR208_04110	COG0556	nucleotide-excision repair
IR208_04115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IR208_04120	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IR208_04130	COG0463	Glycosyl transferase, family 2
IR208_04140	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IR208_04145	COG0463	Glycosyl transferase, family 2
IR208_04145	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IR208_04150	COG1682	transport, permease protein
IR208_04155	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IR208_04160	COG3595	metallopeptidase activity
IR208_04170	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IR208_04175	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IR208_04180	COG0546	phosphoglycolate phosphatase activity
IR208_04185	COG0110	maltose O-acetyltransferase activity
IR208_04190	COG0457	Tetratricopeptide repeat
IR208_04195	COG0492	ferredoxin-NADP+ reductase activity
IR208_04200	COG1051	belongs to the nudix hydrolase family
IR208_04205	COG1660	Displays ATPase and GTPase activities
IR208_04210	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IR208_04215	COG1481	regulation of sporulation
IR208_04220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_04255	COG3842	ATPase activity
IR208_04260	COG2508	Transcriptional regulator
IR208_04270	COG0189	ligase activity
IR208_04275	COG0189	ligase activity
IR208_04285	COG4399	Belongs to the UPF0754 family
IR208_04295	COG0561	phosphatase activity
IR208_04300	COG1024	Enoyl-CoA hydratase
IR208_04310	COG0861	Integral membrane protein TerC family
IR208_04315	COG0701	Predicted permease
IR208_04320	COG3689	TIGRFAM TIGR03943 family protein
IR208_04325	COG0420	3'-5' exonuclease activity
IR208_04330	COG4717	serine-type aminopeptidase activity
IR208_04335	COG3481	metal-dependent phosphohydrolase, HD sub domain
IR208_04345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IR208_04360	COG1846	Transcriptional regulator
IR208_04380	COG0537	adenosine 5'-monophosphoramidase activity
IR208_04385	COG1131	(ABC) transporter
IR208_04390	COG4473	ABC transporter
IR208_04395	COG1473	amidohydrolase
IR208_04400	COG3069	C4-dicarboxylate transmembrane transporter activity
IR208_04405	COG2329	Antibiotic biosynthesis monooxygenase
IR208_04410	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IR208_04415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IR208_04420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IR208_04425	COG1309	transcriptional regulator
IR208_04430	COG1511	domain protein
IR208_04435	COG2190	(PTS) system
IR208_04435	COG1263	PTS System
IR208_04435	COG1263	PTS System
IR208_04435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_04435	COG2190	(PTS) system
IR208_04435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_04440	COG1349	DNA-binding transcription factor activity
IR208_04450	COG0697	spore germination
IR208_04455	COG1012	belongs to the aldehyde dehydrogenase family
IR208_04460	COG1999	signal sequence binding
IR208_04475	COG0095	Lipoate-protein ligase
IR208_04480	COG0318	PFAM AMP-dependent synthetase and ligase
IR208_04485	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IR208_04495	COG0501	Belongs to the peptidase M48B family
IR208_04515	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IR208_04520	COG1074	ATP-dependent DNA helicase activity
IR208_04555	COG2311	Membrane
IR208_04560	COG0179	Fumarylacetoacetate (FAA) hydrolase
IR208_04575	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_04580	COG1307	EDD domain protein, DegV family
IR208_04600	COG0561	phosphatase activity
IR208_04605	COG2151	metal-sulfur cluster biosynthetic enzyme
IR208_04635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IR208_04640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IR208_04655	COG4608	Belongs to the ABC transporter superfamily
IR208_04660	COG0601	transmembrane transport
IR208_04670	COG0747	negative chemotaxis
IR208_04680	COG0180	Tryptophanyl-tRNA synthetase
IR208_04695	COG4166	transmembrane transport
IR208_04700	COG0601	transmembrane transport
IR208_04705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR208_04710	COG0444	Belongs to the ABC transporter superfamily
IR208_04715	COG4608	Belongs to the ABC transporter superfamily
IR208_04720	COG1393	Belongs to the ArsC family
IR208_04725	COG4862	establishment of competence for transformation
IR208_04730	COG4469	Competence protein
IR208_04735	COG1164	Oligoendopeptidase f
IR208_04745	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IR208_04750	COG2346	COG2346, Truncated hemoglobins
IR208_04755	COG0741	lytic transglycosylase activity
IR208_04760	COG4116	CYTH
IR208_04770	COG2357	RelA SpoT domain protein
IR208_04780	COG0564	pseudouridine synthase activity
IR208_04785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IR208_04790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IR208_04825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IR208_04850	COG2153	protein acetylation
IR208_04860	COG2382	esterase
IR208_04890	COG1940	carbohydrate kinase activity
IR208_04900	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_04905	COG4152	abc transporter atp-binding protein
IR208_04910	COG1668	transmembrane transport
IR208_04920	COG3579	cysteine-type endopeptidase activity
IR208_04980	COG1247	-acetyltransferase
IR208_05000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IR208_05005	COG2059	Chromate
IR208_05010	COG2059	Chromate
IR208_05015	COG1522	sequence-specific DNA binding
IR208_05030	COG0154	amidase activity
IR208_05150	COG4974	Belongs to the 'phage' integrase family
IR208_05165	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IR208_05170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IR208_05195	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_05210	COG1959	2 iron, 2 sulfur cluster binding
IR208_05220	COG0730	response to heat
IR208_05225	COG0783	Belongs to the Dps family
IR208_05230	COG0673	inositol 2-dehydrogenase activity
IR208_05235	COG3852	Histidine kinase
IR208_05240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IR208_05250	COG0861	Integral membrane protein TerC family
IR208_05270	COG5002	protein histidine kinase activity
IR208_05275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IR208_05290	COG0542	response to heat
IR208_05295	COG3949	Membrane
IR208_05305	COG4873	Protein conserved in bacteria
IR208_05315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_05330	COG2084	Dehydrogenase
IR208_05335	COG0436	Aminotransferase
IR208_05340	COG0835	chemotaxis
IR208_05340	COG0784	Response regulator, receiver
IR208_05350	COG2409	Drug exporters of the RND superfamily
IR208_05350	COG1033	growth of symbiont in host cell
IR208_05365	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_05375	COG4703	Protein of unknown function (DUF1797)
IR208_05380	COG0517	IMP dehydrogenase activity
IR208_05385	COG0583	DNA-binding transcription factor activity
IR208_05390	COG2171	N-acyltransferase activity
IR208_05395	COG1473	amidohydrolase
IR208_05405	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IR208_05450	COG1982	Orn Lys Arg decarboxylase major
IR208_05460	COG4476	Belongs to the UPF0223 family
IR208_05475	COG0483	inositol monophosphate 1-phosphatase activity
IR208_05485	COG1217	gtp-binding protein TYPA
IR208_05495	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IR208_05500	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IR208_05505	COG4838	Belongs to the UPF0358 family
IR208_05510	COG0772	Belongs to the SEDS family
IR208_05515	COG1612	heme a metabolic process
IR208_05520	COG0109	protoheme IX farnesyltransferase activity
IR208_05540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IR208_05545	COG3336	cytochrome c oxidase
IR208_05555	COG2340	Cysteine-rich secretory protein family
IR208_05560	COG2050	protein possibly involved in aromatic compounds catabolism
IR208_05580	COG3679	Belongs to the UPF0342 family
IR208_05585	COG4471	UPF0298 protein
IR208_05595	COG0742	ribosomal rna small subunit methyltransferase
IR208_05600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IR208_05605	COG3314	Sporulation integral membrane protein YlbJ
IR208_05610	COG1752	Esterase of the alpha-beta hydrolase superfamily
IR208_05615	COG3480	Lon protease (S16) C-terminal proteolytic domain
IR208_05620	COG1323	Belongs to the UPF0348 family
IR208_05625	COG1399	metal-binding, possibly nucleic acid-binding protein
IR208_05630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IR208_05640	COG0454	-acetyltransferase
IR208_05645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IR208_05650	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IR208_05655	COG2001	Belongs to the MraZ family
IR208_05660	COG0275	rRNA processing
IR208_05665	COG4839	cell division protein FtsL
IR208_05670	COG0768	penicillin binding
IR208_05675	COG0768	penicillin binding
IR208_05690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IR208_05695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IR208_05700	COG0772	Belongs to the SEDS family
IR208_05705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IR208_05710	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IR208_05715	COG0849	cell division
IR208_05720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IR208_05730	COG1191	sigma factor activity
IR208_05735	COG1191	sigma factor activity
IR208_05740	COG1873	PFAM PRC-barrel domain
IR208_05745	COG1388	LysM domain
IR208_05745	COG3584	3D domain protein
IR208_05755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IR208_05760	COG1799	cell septum assembly
IR208_05765	COG0762	integral membrane protein
IR208_05770	COG2302	S4 RNA-binding domain
IR208_05775	COG3599	regulation of cell shape
IR208_05790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IR208_05795	COG0564	pseudouridine synthase activity
IR208_05800	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IR208_05805	COG0540	Belongs to the ATCase OTCase family
IR208_05810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IR208_05825	COG0543	2 iron, 2 sulfur cluster binding
IR208_05830	COG0167	dihydroorotate dehydrogenase activity
IR208_05835	COG0284	orotidine-5'-phosphate decarboxylase activity
IR208_05840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IR208_05855	COG1917	Cupin 2, conserved barrel domain protein
IR208_05855	COG2207	Transcriptional regulator
IR208_05860	COG1070	Carbohydrate kinase
IR208_05865	COG4806	L-rhamnose isomerase
IR208_05870	COG0235	Class ii aldolase
IR208_05875	COG1454	alcohol dehydrogenase
IR208_05880	COG1803	Methylglyoxal synthase
IR208_05885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IR208_05890	COG0477	Major facilitator Superfamily
IR208_05895	COG0477	Major facilitator Superfamily
IR208_05900	COG1309	transcriptional regulator
IR208_05915	COG0628	permease
IR208_05920	COG0561	phosphatase activity
IR208_05950	COG0720	synthase
IR208_05960	COG0385	Bile acid
IR208_05970	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IR208_05975	COG1561	YicC-like family, N-terminal region
IR208_05980	COG2052	Domain of unknown function (DUF370)
IR208_05985	COG0194	GDP metabolic process
IR208_05990	COG1758	RNA polymerase activity
IR208_05995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IR208_06000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IR208_06005	COG0242	peptide deformylase activity
IR208_06010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IR208_06015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IR208_06015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IR208_06020	COG0631	protein serine/threonine phosphatase activity
IR208_06025	COG2815	serine threonine protein kinase
IR208_06025	COG0515	serine threonine protein kinase
IR208_06035	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IR208_06040	COG1564	THIamine pyrophosphokinase
IR208_06050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IR208_06060	COG1302	Protein conserved in bacteria
IR208_06065	COG1461	Dihydroxyacetone kinase
IR208_06070	COG1760	l-serine dehydratase
IR208_06075	COG1760	l-serine dehydratase
IR208_06080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IR208_06085	COG1349	DNA-binding transcription factor activity
IR208_06090	COG0416	fatty acid biosynthetic process
IR208_06095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IR208_06100	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_06110	COG0571	ribonuclease III activity
IR208_06115	COG1196	nuclear chromosome segregation
IR208_06120	COG0552	protein localization to endoplasmic reticulum
IR208_06125	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
IR208_06130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IR208_06140	COG1837	Belongs to the UPF0109 family
IR208_06150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IR208_06155	COG0336	Belongs to the RNA methyltransferase TrmD family
IR208_06170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IR208_06185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IR208_06190	COG0045	succinate-CoA ligase (ADP-forming) activity
IR208_06195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IR208_06200	COG0758	DNA mediated transformation
IR208_06205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IR208_06210	COG4974	Belongs to the 'phage' integrase family
IR208_06215	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IR208_06225	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IR208_06230	COG1815	bacterial-type flagellum-dependent cell motility
IR208_06235	COG1558	bacterial-type flagellum-dependent cell motility
IR208_06240	COG1677	Flagellar hook-basal body complex protein FliE
IR208_06245	COG1766	The M ring may be actively involved in energy transduction
IR208_06250	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IR208_06255	COG1317	bacterial-type flagellum organization
IR208_06260	COG1157	protein secretion by the type III secretion system
IR208_06265	COG2882	bacterial-type flagellum organization
IR208_06280	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IR208_06290	COG4786	Flagellar basal body rod
IR208_06300	COG1580	Controls the rotational direction of flagella during chemotaxis
IR208_06305	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IR208_06310	COG1776	CheC inhibitor of MCP methylation
IR208_06310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IR208_06315	COG2201	protein-glutamate methylesterase activity
IR208_06320	COG3190	flagellar
IR208_06325	COG1338	Plays a role in the flagellum-specific transport system
IR208_06330	COG1987	bacterial-type flagellum assembly
IR208_06340	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IR208_06345	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IR208_06350	COG1419	protein localization to endoplasmic reticulum
IR208_06355	COG0455	bacterial-type flagellum organization
IR208_06360	COG2201	protein-glutamate methylesterase activity
IR208_06365	COG2198	Histidine kinase
IR208_06365	COG0643	Histidine kinase
IR208_06370	COG0835	chemotaxis
IR208_06375	COG1776	CheC inhibitor of MCP methylation
IR208_06380	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IR208_06385	COG1191	sigma factor activity
IR208_06395	COG0052	Belongs to the universal ribosomal protein uS2 family
IR208_06400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IR208_06405	COG0528	UMP kinase activity
IR208_06410	COG0233	cytoplasmic translational termination
IR208_06415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IR208_06420	COG4589	Belongs to the CDS family
IR208_06430	COG0750	zinc metalloprotease
IR208_06435	COG0442	prolyl-tRNA aminoacylation
IR208_06440	COG2176	DNA-directed DNA polymerase activity
IR208_06445	COG0779	Required for maturation of 30S ribosomal subunits
IR208_06450	COG0195	Participates in both transcription termination and antitermination
IR208_06455	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IR208_06460	COG1358	cellular component organization or biogenesis
IR208_06470	COG1550	Protein conserved in bacteria
IR208_06475	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IR208_06480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IR208_06485	COG0196	riboflavin kinase activity
IR208_06490	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IR208_06495	COG1185	polyribonucleotide nucleotidyltransferase activity
IR208_06500	COG0726	polysaccharide deacetylase
IR208_06505	COG0612	Peptidase, M16
IR208_06510	COG1873	PFAM PRC-barrel domain
IR208_06515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IR208_06520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IR208_06525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IR208_06530	COG0527	aspartate kinase activity
IR208_06540	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IR208_06545	COG0740	serine-type endopeptidase activity
IR208_06555	COG1674	ftsk spoiiie
IR208_06555	COG4980	gas vesicle protein
IR208_06560	COG1744	ABC transporter substrate-binding protein PnrA-like
IR208_06570	COG4603	Belongs to the binding-protein-dependent transport system permease family
IR208_06575	COG1079	Belongs to the binding-protein-dependent transport system permease family
IR208_06580	COG0612	Peptidase, M16
IR208_06585	COG0612	Peptidase, M16
IR208_06590	COG0300	oxidoreductase activity
IR208_06605	COG1426	Protein conserved in bacteria
IR208_06610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IR208_06615	COG1058	Belongs to the CinA family
IR208_06615	COG1546	Belongs to the CinA family
IR208_06625	COG1418	mRNA catabolic process
IR208_06630	COG1692	metallophosphoesterase
IR208_06635	COG2359	stage V sporulation protein S
IR208_06640	COG0826	peptidase U32
IR208_06645	COG0826	peptidase U32
IR208_06655	COG3829	transcription factor binding
IR208_06660	COG1012	belongs to the aldehyde dehydrogenase family
IR208_06670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IR208_06675	COG4550	Control of competence regulator ComK, YlbF/YmcA
IR208_06685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IR208_06690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IR208_06720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IR208_06730	COG0464	growth
IR208_06735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IR208_06740	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
IR208_06745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IR208_06765	COG1321	iron dependent repressor
IR208_06770	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IR208_06780	COG1418	mRNA catabolic process
IR208_06785	COG0488	(ABC) transporter
IR208_06790	COG1413	lyase activity
IR208_06805	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IR208_06810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IR208_06815	COG1272	protein, Hemolysin III
IR208_06820	COG2755	lipolytic protein G-D-S-L family
IR208_06830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IR208_06830	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IR208_06835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IR208_06840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IR208_06850	COG0840	transmembrane signaling receptor activity
IR208_06855	COG4479	Belongs to the UPF0346 family
IR208_06875	COG1876	peptidase activity
IR208_06880	COG3409	Peptidoglycan-binding domain 1 protein
IR208_06880	COG0793	Belongs to the peptidase S41A family
IR208_06885	COG1846	Transcriptional regulator
IR208_06890	COG2340	Cysteine-rich secretory protein family
IR208_06895	COG0534	Mate efflux family protein
IR208_06910	COG1793	dna ligase
IR208_06910	COG3285	dna ligase
IR208_06915	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IR208_06920	COG0671	phosphoesterase, PA-phosphatase related
IR208_06925	COG1368	sulfuric ester hydrolase activity
IR208_06940	COG1331	Highly conserved protein containing a thioredoxin domain
IR208_06945	COG2814	Major facilitator Superfamily
IR208_06950	COG0745	RESPONSE REGULATOR receiver
IR208_06955	COG5002	protein histidine kinase activity
IR208_06965	COG0567	Dehydrogenase, E1 component
IR208_06970	COG0508	dehydrogenase complex catalyzes the overall conversion of
IR208_06975	COG1012	belongs to the aldehyde dehydrogenase family
IR208_06990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IR208_07000	COG1054	Belongs to the UPF0176 family
IR208_07005	COG2135	peptidase activity
IR208_07015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR208_07020	COG0517	IMP dehydrogenase activity
IR208_07020	COG0516	GMP reductase activity
IR208_07025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR208_07025	COG0723	plastoquinol--plastocyanin reductase activity
IR208_07030	COG3584	3D domain protein
IR208_07030	COG1388	LysM domain
IR208_07035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IR208_07040	COG1113	amino acid transport
IR208_07045	COG1280	lysine exporter protein (LysE YggA)
IR208_07050	COG0598	Magnesium transport protein CorA
IR208_07065	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IR208_07070	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IR208_07075	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IR208_07080	COG0131	Imidazoleglycerol-phosphate dehydratase
IR208_07085	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IR208_07095	COG0107	imidazoleglycerol-phosphate synthase activity
IR208_07100	COG0140	phosphoribosyl-ATP diphosphatase activity
IR208_07100	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IR208_07110	COG2391	methyltransferase activity
IR208_07115	COG2962	Rard protein
IR208_07120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IR208_07125	COG0569	domain protein
IR208_07145	COG2807	transmembrane transport
IR208_07150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IR208_07160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IR208_07170	COG1278	Cold shock
IR208_07175	COG0302	gtp cyclohydrolase
IR208_07180	COG3634	alkyl hydroperoxide reductase activity
IR208_07195	COG0577	efflux transmembrane transporter activity
IR208_07200	COG1136	(ABC) transporter
IR208_07205	COG0642	Histidine kinase
IR208_07210	COG0745	RESPONSE REGULATOR receiver
IR208_07235	COG0640	Transcriptional regulator
IR208_07240	COG2814	Major facilitator Superfamily
IR208_07245	COG5039	Polysaccharide pyruvyl transferase
IR208_07255	COG1113	amino acid transport
IR208_07270	COG0477	Major facilitator Superfamily
IR208_07280	COG1132	(ABC) transporter
IR208_07285	COG1132	(ABC) transporter
IR208_07295	COG1380	Effector of murein hydrolase LrgA
IR208_07300	COG1346	cytolysis
IR208_07305	COG0318	PFAM AMP-dependent synthetase and ligase
IR208_07330	COG2309	aminopeptidase activity
IR208_07340	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IR208_07360	COG0824	Thioesterase
IR208_07370	COG4841	protein insertion into membrane
IR208_07375	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IR208_07380	COG1832	CoA-binding protein
IR208_07385	COG0187	DNA topoisomerase II activity
IR208_07390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IR208_07405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IR208_07410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IR208_07410	COG0574	Belongs to the PEP-utilizing enzyme family
IR208_07435	COG2070	2-Nitropropane dioxygenase
IR208_07445	COG0681	Belongs to the peptidase S26 family
IR208_07450	COG0473	3-isopropylmalate dehydrogenase activity
IR208_07455	COG2226	methyltransferase
IR208_07480	COG0456	acetyltransferase
IR208_07485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IR208_07490	COG0456	acetyltransferase
IR208_07520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IR208_07525	COG0351	phosphomethylpyrimidine kinase
IR208_07530	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_07535	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IR208_07540	COG0351	phosphomethylpyrimidine kinase
IR208_07550	COG2258	MOSC domain
IR208_07585	COG1309	transcriptional regulator
IR208_07590	COG2814	Major facilitator Superfamily
IR208_07595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR208_07600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IR208_07610	COG1809	phosphosulfolactate synthase activity
IR208_07615	COG2045	Belongs to the ComB family
IR208_07620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IR208_07625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IR208_07635	COG0789	Transcriptional regulator
IR208_07640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IR208_07645	COG0697	spore germination
IR208_07650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IR208_07655	COG0022	dehydrogenase e1 component
IR208_07660	COG0508	dehydrogenase complex catalyzes the overall conversion of
IR208_07665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IR208_07670	COG3284	Transcriptional regulator
IR208_07675	COG3264	Mechanosensitive ion channel
IR208_07675	COG1511	domain protein
IR208_07690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IR208_07695	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IR208_07710	COG0183	Belongs to the thiolase family
IR208_07715	COG0318	PFAM AMP-dependent synthetase and ligase
IR208_07725	COG0561	phosphatase activity
IR208_07730	COG2322	membrane
IR208_07745	COG0039	L-malate dehydrogenase activity
IR208_07750	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_07755	COG2223	nitrite transmembrane transporter activity
IR208_07760	COG3773	Cell wall hydrolase
IR208_07765	COG0708	Exodeoxyribonuclease III
IR208_07775	COG0297	glycogen (starch) synthase activity
IR208_07780	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IR208_07785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IR208_07790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IR208_07810	COG1247	-acetyltransferase
IR208_07815	COG0494	nUDIX hydrolase
IR208_07820	COG1914	H( )-stimulated, divalent metal cation uptake system
IR208_07825	COG0783	Belongs to the Dps family
IR208_07835	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IR208_07840	COG1131	(ABC) transporter
IR208_07865	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IR208_07875	COG2030	dehydratase
IR208_07880	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_07895	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
IR208_07900	COG0709	Synthesizes selenophosphate from selenide and ATP
IR208_07915	COG0701	Predicted permease
IR208_07920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IR208_07925	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IR208_07935	COG1252	NADH dehydrogenase
IR208_07940	COG2404	hydrolase activity, acting on ester bonds
IR208_07950	COG4990	cell redox homeostasis
IR208_07955	COG0789	Transcriptional regulator
IR208_07980	COG0436	Aminotransferase
IR208_07985	COG0165	Argininosuccinate lyase
IR208_07990	COG0137	argininosuccinate synthase activity
IR208_07995	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IR208_08000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IR208_08005	COG0505	Belongs to the CarA family
IR208_08010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IR208_08015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IR208_08020	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IR208_08025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IR208_08040	COG3546	catalase activity
IR208_08060	COG1619	proteins homologs of microcin C7 resistance protein MccF
IR208_08065	COG2027	D-alanyl-D-alanine carboxypeptidase
IR208_08070	COG0204	Acyl-transferase
IR208_08080	COG4846	Membrane protein involved in cytochrome C biogenesis
IR208_08085	COG2201	protein-glutamate methylesterase activity
IR208_08090	COG0785	Cytochrome C biogenesis protein
IR208_08095	COG3763	UPF0154 protein
IR208_08110	COG4224	UPF0291 protein
IR208_08115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IR208_08125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IR208_08130	COG0174	glutamine synthetase
IR208_08135	COG0789	Transcriptional regulator
IR208_08140	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IR208_08155	COG2233	PERMEase
IR208_08165	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IR208_08170	COG0116	Belongs to the methyltransferase superfamily
IR208_08185	COG4474	Belongs to the UPF0398 family
IR208_08195	COG3359	exonuclease
IR208_08200	COG1111	helicase
IR208_08200	COG1205	dead DEAH box helicase
IR208_08205	COG0071	Belongs to the small heat shock protein (HSP20) family
IR208_08230	COG3331	DNA recombination
IR208_08235	COG4499	WXG100 protein secretion system (Wss), protein YukC
IR208_08235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IR208_08240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IR208_08245	COG3935	DnaD domain protein
IR208_08250	COG0017	Asparaginyl-tRNA synthetase
IR208_08265	COG1199	ATP-dependent helicase activity
IR208_08265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IR208_08270	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IR208_08275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IR208_08295	COG0438	transferase activity, transferring glycosyl groups
IR208_08300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IR208_08305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IR208_08310	COG1694	Mazg nucleotide pyrophosphohydrolase
IR208_08315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IR208_08325	COG2738	Putative neutral zinc metallopeptidase
IR208_08335	COG4347	Protein of unknown function (DUF1405)
IR208_08345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IR208_08360	COG5582	Belongs to the UPF0302 family
IR208_08365	COG0457	Tetratricopeptide repeat
IR208_08370	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IR208_08375	COG0287	Prephenate dehydrogenase
IR208_08380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IR208_08385	COG4401	Chorismate mutase type I
IR208_08390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IR208_08395	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IR208_08400	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IR208_08405	COG0105	UTP biosynthetic process
IR208_08410	COG0142	geranyltranstransferase activity
IR208_08415	COG2226	methyltransferase
IR208_08420	COG0142	geranyltranstransferase activity
IR208_08430	COG0776	regulation of translation
IR208_08435	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IR208_08455	COG1160	GTP binding
IR208_08470	COG0539	negative regulation of cytoplasmic translation
IR208_08475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IR208_08480	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
IR208_08485	COG2959	enzyme of heme biosynthesis
IR208_08490	COG3773	Cell wall hydrolase
IR208_08490	COG3409	Peptidoglycan-binding domain 1 protein
IR208_08495	COG2339	peptidase activity
IR208_08500	COG0492	ferredoxin-NADP+ reductase activity
IR208_08505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IR208_08515	COG1408	metallophosphoesterase
IR208_08530	COG3546	catalase activity
IR208_08545	COG1266	CAAX protease self-immunity
IR208_08550	COG0514	ATP-dependent DNA helicase (RecQ)
IR208_08560	COG1141	Ferredoxin
IR208_08565	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IR208_08570	COG0739	heme binding
IR208_08570	COG0741	lytic transglycosylase activity
IR208_08570	COG1196	nuclear chromosome segregation
IR208_08575	COG5002	protein histidine kinase activity
IR208_08580	COG0745	RESPONSE REGULATOR receiver
IR208_08585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IR208_08590	COG1333	cytochrome c biogenesis protein
IR208_08595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IR208_08600	COG1187	pseudouridine synthase activity
IR208_08605	COG0700	Nucleoside recognition
IR208_08610	COG2715	membrane protein required for spore maturation
IR208_08615	COG1686	Belongs to the peptidase S11 family
IR208_08620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IR208_08645	COG0697	spore germination
IR208_08665	COG1191	sigma factor activity
IR208_08680	COG1686	Belongs to the peptidase S11 family
IR208_08685	COG4974	Belongs to the 'phage' integrase family
IR208_08695	COG0735	belongs to the Fur family
IR208_08700	COG1300	Membrane
IR208_08705	COG1379	DNA repair
IR208_08720	COG0667	Aldo Keto reductase
IR208_08730	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
IR208_08735	COG3853	Toxic anion resistance protein (TelA)
IR208_08740	COG1073	alpha beta
IR208_08745	COG3858	chitin binding
IR208_08745	COG1388	LysM domain
IR208_08755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IR208_08760	COG0300	oxidoreductase activity
IR208_08765	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IR208_08775	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IR208_08780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IR208_08790	COG2195	Cleaves the N-terminal amino acid of tripeptides
IR208_08805	COG1376	ErfK ybiS ycfS ynhG family protein
IR208_08815	COG1105	Belongs to the carbohydrate kinase PfkB family
IR208_08820	COG0508	dehydrogenase complex catalyzes the overall conversion of
IR208_08825	COG0022	dehydrogenase e1 component
IR208_08830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IR208_08835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IR208_08855	COG0584	glycerophosphoryl diester phosphodiesterase
IR208_08860	COG0745	RESPONSE REGULATOR receiver
IR208_08865	COG0750	zinc metalloprotease
IR208_08870	COG0497	DNA recombination
IR208_08880	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IR208_08885	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IR208_08900	COG1570	exodeoxyribonuclease VII activity
IR208_08915	COG1302	Protein conserved in bacteria
IR208_08920	COG0439	Biotin carboxylase
IR208_08925	COG0511	ligase activity, forming carbon-carbon bonds
IR208_08965	COG3854	ATPases associated with a variety of cellular activities
IR208_08970	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IR208_08975	COG0006	proline dipeptidase activity
IR208_08980	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IR208_08990	COG3872	metal-dependent enzyme
IR208_09000	COG1752	Esterase of the alpha-beta hydrolase superfamily
IR208_09010	COG3327	negative regulation of DNA-templated transcription, initiation
IR208_09015	COG0183	Belongs to the thiolase family
IR208_09020	COG1250	3-hydroxyacyl-CoA dehydrogenase
IR208_09025	COG1012	belongs to the aldehyde dehydrogenase family
IR208_09030	COG1024	Enoyl-CoA hydratase
IR208_09035	COG0492	ferredoxin-NADP+ reductase activity
IR208_09040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IR208_09045	COG0095	Lipoate-protein ligase
IR208_09050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IR208_09055	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IR208_09065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IR208_09070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IR208_09085	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IR208_09110	COG4537	Required for transformation and DNA binding
IR208_09115	COG1459	type II secretion system
IR208_09120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IR208_09135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR208_09145	COG1940	carbohydrate kinase activity
IR208_09150	COG4483	Protein conserved in bacteria
IR208_09155	COG0457	Tetratricopeptide repeat
IR208_09155	COG0705	Rhomboid family
IR208_09165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IR208_09175	COG0768	penicillin binding
IR208_09180	COG0477	Major facilitator Superfamily
IR208_09185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IR208_09195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IR208_09200	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
IR208_09205	COG0735	belongs to the Fur family
IR208_09210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IR208_09215	COG1121	(ABC) transporter
IR208_09225	COG0791	NLP P60 protein
IR208_09225	COG3883	PFAM NLP P60 protein
IR208_09230	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IR208_09235	COG0513	Belongs to the DEAD box helicase family
IR208_09245	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IR208_09250	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IR208_09255	COG2384	SAM-dependent methyltransferase
IR208_09260	COG2010	Cytochrome c
IR208_09270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IR208_09275	COG0358	DNA primase activity
IR208_09285	COG0517	IMP dehydrogenase activity
IR208_09290	COG1381	Involved in DNA repair and RecF pathway recombination
IR208_09305	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IR208_09310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IR208_09315	COG1480	7TM receptor with intracellular HD hydrolase
IR208_09320	COG1702	phosphate starvation-inducible protein PhoH
IR208_09335	COG1610	YqeY-like protein
IR208_09350	COG1283	sodium-dependent phosphate transmembrane transporter activity
IR208_09355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IR208_09360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IR208_09365	COG2264	protein methyltransferase activity
IR208_09375	COG0443	Heat shock 70 kDa protein
IR208_09380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IR208_09390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IR208_09395	COG0481	GTPase activity
IR208_09400	COG0860	N-Acetylmuramoyl-L-alanine amidase
IR208_09405	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IR208_09410	COG0268	Binds directly to 16S ribosomal RNA
IR208_09415	COG1466	dna polymerase III delta subunit
IR208_09425	COG2333	competence protein COMEC
IR208_09425	COG0658	competence protein
IR208_09430	COG2131	deaminase
IR208_09435	COG1596	polysaccharide export
IR208_09435	COG1555	photosystem II stabilization
IR208_09440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IR208_09445	COG2226	methyltransferase
IR208_09450	COG0799	negative regulation of ribosome biogenesis
IR208_09455	COG1713	HD superfamily hydrolase involved in NAD metabolism
IR208_09460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IR208_09465	COG1534	Rna-binding protein
IR208_09475	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IR208_09480	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IR208_09485	COG0247	lactate metabolic process
IR208_09490	COG0277	FAD linked oxidase domain protein
IR208_09495	COG3835	regulator
IR208_09500	COG2132	Multicopper oxidase
IR208_09505	COG0071	Belongs to the small heat shock protein (HSP20) family
IR208_09510	COG2210	Belongs to the sulfur carrier protein TusA family
IR208_09525	COG0446	pyridine nucleotide-disulphide oxidoreductase
IR208_09540	COG0071	Belongs to the small heat shock protein (HSP20) family
IR208_09550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IR208_09560	COG1704	LemA family
IR208_09570	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IR208_09590	COG1183	phosphatidylcholine synthase activity
IR208_09610	COG0450	alkyl hydroperoxide reductase
IR208_09640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IR208_09645	COG0572	uridine kinase
IR208_09650	COG4122	O-methyltransferase activity
IR208_09655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IR208_09660	COG3906	Belongs to the UPF0473 family
IR208_09665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IR208_09670	COG4472	Bacterial protein of unknown function (DUF965)
IR208_09675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IR208_09680	COG0628	permease
IR208_09710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IR208_09720	COG0482	sulfurtransferase activity
IR208_09725	COG1104	cysteine desulfurase activity
IR208_09730	COG1959	2 iron, 2 sulfur cluster binding
IR208_09750	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_09755	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IR208_09760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IR208_09765	COG0385	Bile acid
IR208_09775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IR208_09780	COG0124	histidyl-tRNA synthetase
IR208_09790	COG0860	N-Acetylmuramoyl-L-alanine amidase
IR208_09790	COG3103	Sh3 type 3 domain protein
IR208_09790	COG4991	sh3 domain protein
IR208_09795	COG2814	Major facilitator Superfamily
IR208_09800	COG1566	PFAM secretion protein HlyD family protein
IR208_09805	COG1846	Transcriptional regulator
IR208_09810	COG1490	D-aminoacyl-tRNA deacylase activity
IR208_09815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IR208_09820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IR208_09825	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IR208_09825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IR208_09830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IR208_09830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IR208_09840	COG2244	polysaccharide biosynthetic process
IR208_09845	COG2323	membrane
IR208_09855	COG1862	Preprotein translocase
IR208_09860	COG0343	queuine tRNA-ribosyltransferase activity
IR208_09865	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IR208_09880	COG0632	four-way junction helicase activity
IR208_09885	COG0217	transcriptional regulatory protein
IR208_09895	COG1388	LysM domain
IR208_09900	COG1827	regulation of RNA biosynthetic process
IR208_09905	COG0077	Prephenate dehydratase
IR208_09910	COG4492	Belongs to the UPF0735 family
IR208_09915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IR208_09920	COG3290	protein histidine kinase activity
IR208_09925	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IR208_09930	COG2868	ribosomal protein
IR208_09935	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IR208_09940	COG1530	ribonuclease E activity
IR208_09945	COG1994	Peptidase M50
IR208_09955	COG2894	cell division
IR208_09960	COG0850	regulation of cytokinetic process
IR208_09970	COG1792	Involved in formation and maintenance of cell shape
IR208_09975	COG1077	Cell shape determining protein MreB Mrl
IR208_09980	COG2003	Belongs to the UPF0758 family
IR208_09990	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IR208_10020	COG1459	type II secretion system
IR208_10030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IR208_10065	COG0285	dihydrofolate synthase activity
IR208_10070	COG0525	valine-tRNA ligase activity
IR208_10080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IR208_10085	COG1388	LysM domain
IR208_10085	COG1388	LysM domain
IR208_10090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IR208_10095	COG0113	porphobilinogen synthase activity
IR208_10105	COG0181	hydroxymethylbilane synthase activity
IR208_10110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IR208_10125	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IR208_10130	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IR208_10135	COG1067	ATP-dependent peptidase activity
IR208_10135	COG0470	DNA polymerase III
IR208_10145	COG0544	peptidyl-prolyl cis-trans isomerase activity
IR208_10150	COG1477	protein flavinylation
IR208_10150	COG0457	Tetratricopeptide repeat
IR208_10175	COG0622	Phosphoesterase
IR208_10180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IR208_10185	COG5401	PFAM Sporulation and spore germination
IR208_10195	COG5577	PFAM Coat F domain
IR208_10200	COG1063	alcohol dehydrogenase
IR208_10205	COG5577	PFAM Coat F domain
IR208_10220	COG1846	Transcriptional regulator
IR208_10245	COG2197	response regulator
IR208_10250	COG0824	Thioesterase
IR208_10255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IR208_10260	COG1053	succinate dehydrogenase
IR208_10265	COG2009	succinate dehydrogenase
IR208_10270	COG1719	4-vinyl reductase, 4VR
IR208_10280	COG0322	excinuclease ABC activity
IR208_10285	COG3118	belongs to the thioredoxin family
IR208_10290	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IR208_10295	COG2086	electron transfer activity
IR208_10300	COG1024	Enoyl-CoA hydratase
IR208_10305	COG1309	transcriptional regulator
IR208_10310	COG0318	PFAM AMP-dependent synthetase and ligase
IR208_10315	COG1193	negative regulation of DNA recombination
IR208_10320	COG1796	DNA polymerase
IR208_10320	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IR208_10325	COG1286	toxin biosynthetic process
IR208_10330	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IR208_10340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IR208_10340	COG0072	phenylalanine-tRNA ligase activity
IR208_10345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IR208_10350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IR208_10385	COG2329	Antibiotic biosynthesis monooxygenase
IR208_10395	COG1695	Transcriptional regulator
IR208_10415	COG0431	NADPH-dependent FMN reductase
IR208_10450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IR208_10460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IR208_10475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IR208_10485	COG1484	DNA-dependent DNA replication
IR208_10490	COG3611	Membrane attachment protein
IR208_10495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IR208_10500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IR208_10505	COG0237	dephospho-CoA kinase activity
IR208_10510	COG1971	Probably functions as a manganese efflux pump
IR208_10515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IR208_10520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IR208_10520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IR208_10525	COG0039	L-malate dehydrogenase activity
IR208_10530	COG0538	isocitrate dehydrogenase activity
IR208_10535	COG0372	Belongs to the citrate synthase family
IR208_10540	COG2707	UPF0756 membrane protein
IR208_10545	COG0628	permease
IR208_10555	COG0205	6-phosphofructokinase activity
IR208_10560	COG0825	malonyl-CoA metabolic process
IR208_10565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IR208_10570	COG0281	malic enzyme
IR208_10575	COG0587	DNA-directed DNA polymerase activity
IR208_10590	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IR208_10600	COG4109	DRTGG domain
IR208_10605	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IR208_10610	COG0006	proline dipeptidase activity
IR208_10620	COG0589	response to stress
IR208_10630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IR208_10635	COG0827	DNA restriction-modification system
IR208_10640	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IR208_10645	COG3874	Sporulation protein YtfJ
IR208_10655	COG1714	RDD family
IR208_10660	COG0616	signal peptide processing
IR208_10665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IR208_10675	COG0301	tRNA thio-modification
IR208_10680	COG1104	cysteine desulfurase activity
IR208_10685	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
IR208_10690	COG1309	transcriptional regulator
IR208_10695	COG1956	GAF domain-containing protein
IR208_10700	COG2203	Gaf domain
IR208_10700	COG2199	diguanylate cyclase activity
IR208_10705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IR208_10720	COG0506	proline dehydrogenase activity
IR208_10725	COG1012	belongs to the aldehyde dehydrogenase family
IR208_10730	COG3829	transcription factor binding
IR208_10730	COG3290	protein histidine kinase activity
IR208_10740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IR208_10755	COG3383	formate dehydrogenase (NAD+) activity
IR208_10760	COG2427	Protein of unknown function (DUF1641)
IR208_10765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IR208_10770	COG0315	cyclic pyranopterin monophosphate synthase activity
IR208_10775	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IR208_10780	COG0314	molybdopterin synthase activity
IR208_10785	COG1763	Mo-molybdopterin cofactor biosynthetic process
IR208_10790	COG0303	'Molybdopterin
IR208_10805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IR208_10815	COG4149	molybdate abc transporter
IR208_10825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IR208_10830	COG0454	-acetyltransferase
IR208_10835	COG0517	IMP dehydrogenase activity
IR208_10840	COG0123	including yeast histone deacetylase and acetoin utilization protein
IR208_10850	COG1605	Chorismate mutase
IR208_10850	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IR208_10855	COG4980	gas vesicle protein
IR208_10865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IR208_10870	COG1674	ftsk spoiiie
IR208_10880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IR208_10885	COG4848	Belongs to the UPF0354 family
IR208_10890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IR208_10895	COG2208	phosphoserine phosphatase activity
IR208_10900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IR208_10905	COG5002	protein histidine kinase activity
IR208_10905	COG0784	Response regulator, receiver
IR208_10930	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
IR208_10935	COG1363	Peptidase, m42
IR208_10940	COG5584	Small secreted protein
IR208_10945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR208_10950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IR208_10960	COG0510	thiamine kinase activity
IR208_10985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IR208_10990	COG1349	DNA-binding transcription factor activity
IR208_10995	COG2244	polysaccharide biosynthetic process
IR208_11015	COG0495	leucyl-tRNA aminoacylation
IR208_11020	COG2814	Major facilitator Superfamily
IR208_11030	COG0275	rRNA processing
IR208_11040	COG2267	carboxylic ester hydrolase activity
IR208_11045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IR208_11050	COG0367	asparagine synthase
IR208_11055	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IR208_11060	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IR208_11070	COG1506	peptidase
IR208_11075	COG0655	NAD(P)H dehydrogenase (quinone) activity
IR208_11080	COG1070	Carbohydrate kinase
IR208_11085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IR208_11090	COG1116	anion transmembrane transporter activity
IR208_11095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR208_11110	COG0783	Belongs to the Dps family
IR208_11115	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IR208_11125	COG0803	Belongs to the bacterial solute-binding protein 9 family
IR208_11135	COG4948	Mandelate Racemase Muconate Lactonizing
IR208_11140	COG0318	PFAM AMP-dependent synthetase and ligase
IR208_11145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IR208_11150	COG0596	Alpha beta hydrolase
IR208_11155	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IR208_11160	COG1169	isochorismate synthase
IR208_11165	COG1575	Belongs to the MenA family. Type 1 subfamily
IR208_11310	COG1285	pathogenesis
IR208_11325	COG2217	Heavy metal translocating P-type atpase
IR208_11330	COG2608	mercury ion transmembrane transporter activity
IR208_11345	COG1522	sequence-specific DNA binding
IR208_11365	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IR208_11400	COG5002	protein histidine kinase activity
IR208_11405	COG0745	RESPONSE REGULATOR receiver
IR208_11410	COG1388	LysM domain
IR208_11415	COG4221	oxidoreductase activity
IR208_11425	COG0726	polysaccharide deacetylase
IR208_11450	COG0038	chloride channel
IR208_11460	COG0425	Belongs to the sulfur carrier protein TusA family
IR208_11460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IR208_11465	COG1937	Protein conserved in bacteria
IR208_11470	COG1525	nuclease
IR208_11475	COG2190	(PTS) system
IR208_11490	COG3534	alpha-L-arabinofuranosidase
IR208_11495	COG2160	L-arabinose isomerase activity
IR208_11515	COG0395	ABC-type sugar transport system, permease component
IR208_11520	COG1175	transmembrane transport
IR208_11525	COG1653	transport
IR208_11530	COG1609	Transcriptional regulator
IR208_11535	COG3940	Belongs to the glycosyl hydrolase 43 family
IR208_11540	COG2223	nitrite transmembrane transporter activity
IR208_11545	COG3507	Belongs to the glycosyl hydrolase 43 family
IR208_11550	COG3328	transposase activity
IR208_11560	COG0840	transmembrane signaling receptor activity
IR208_11575	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_11580	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
IR208_11595	COG1012	belongs to the aldehyde dehydrogenase family
IR208_11615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IR208_11625	COG2155	Conserved Protein
IR208_11635	COG1098	S1 RNA binding domain
IR208_11645	COG1902	pentaerythritol trinitrate reductase activity
IR208_11650	COG0656	L-ascorbic acid biosynthetic process
IR208_11670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IR208_11680	COG2814	Major facilitator Superfamily
IR208_11685	COG2050	protein possibly involved in aromatic compounds catabolism
IR208_11695	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IR208_11705	COG0697	spore germination
IR208_11715	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IR208_11720	COG3584	3D domain protein
IR208_11730	COG1252	NADH dehydrogenase
IR208_11735	COG0492	ferredoxin-NADP+ reductase activity
IR208_11760	COG0316	Belongs to the HesB IscA family
IR208_11765	COG4837	Protein of unknown function (DUF1462)
IR208_11770	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IR208_11775	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IR208_11780	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IR208_11785	COG0647	UMP catabolic process
IR208_11790	COG2445	Protein of unknown function DUF86
IR208_11795	COG4470	Protein conserved in bacteria
IR208_11800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IR208_11805	COG0739	heme binding
IR208_11815	COG3377	Domain of unknown function (DUF1805)
IR208_11820	COG0737	Belongs to the 5'-nucleotidase family
IR208_11825	COG0719	Fe-S assembly protein
IR208_11830	COG0822	iron-sulfur transferase activity
IR208_11835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IR208_11840	COG0719	Fe-S assembly protein
IR208_11845	COG0396	ATPase activity
IR208_11855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IR208_11860	COG0509	glycine decarboxylation via glycine cleavage system
IR208_11865	COG1393	Belongs to the ArsC family
IR208_11870	COG1960	acyl-CoA dehydrogenase activity
IR208_11875	COG0183	Belongs to the thiolase family
IR208_11880	COG1250	3-hydroxyacyl-CoA dehydrogenase
IR208_11880	COG1024	Enoyl-CoA hydratase
IR208_11895	COG5577	PFAM Coat F domain
IR208_11900	COG0772	Belongs to the SEDS family
IR208_11905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IR208_11920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IR208_11935	COG0753	catalase activity
IR208_11940	COG0671	phosphoesterase, PA-phosphatase related
IR208_11950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IR208_11965	COG1595	DNA-templated transcription, initiation
IR208_11970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IR208_11985	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IR208_11995	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IR208_12000	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_12005	COG2211	Major facilitator Superfamily
IR208_12010	COG1904	glucuronate isomerase
IR208_12015	COG2721	sulfolactate sulfo-lyase activity
IR208_12020	COG0246	Mannitol dehydrogenase
IR208_12030	COG0800	Aldolase
IR208_12035	COG1414	Transcriptional regulator
IR208_12050	COG0488	(ABC) transporter
IR208_12125	COG0557	exoribonuclease II activity
IR208_12135	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IR208_12140	COG0148	phosphopyruvate hydratase activity
IR208_12145	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IR208_12155	COG0126	phosphoglycerate kinase activity
IR208_12175	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IR208_12195	COG3383	formate dehydrogenase (NAD+) activity
IR208_12230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IR208_12245	COG4608	Belongs to the ABC transporter superfamily
IR208_12250	COG0791	NLP P60 protein
IR208_12255	COG4166	transmembrane transport
IR208_12260	COG0444	Belongs to the ABC transporter superfamily
IR208_12265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR208_12270	COG0601	transmembrane transport
IR208_12275	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IR208_12285	COG0598	Magnesium transport protein CorA
IR208_12295	COG2719	SpoVR family
IR208_12300	COG3594	Acyltransferase
IR208_12325	COG1392	Phosphate transport regulator
IR208_12330	COG0306	phosphate transporter
IR208_12345	COG2718	Belongs to the UPF0229 family
IR208_12350	COG2766	serine protein kinase
IR208_12360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IR208_12375	COG2095	MarC family integral membrane protein
IR208_12385	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
IR208_12390	COG0596	Alpha beta hydrolase
IR208_12395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR208_12400	COG0765	amino acid transport
IR208_12405	COG1126	abc transporter atp-binding protein
IR208_12410	COG2116	formate transmembrane transporter activity
IR208_12430	COG1882	Formate acetyltransferase
IR208_12435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IR208_12440	COG0431	NADPH-dependent FMN reductase
IR208_12455	COG1131	(ABC) transporter
IR208_12480	COG0745	RESPONSE REGULATOR receiver
IR208_12485	COG5002	protein histidine kinase activity
IR208_12485	COG3850	Histidine kinase
IR208_12495	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IR208_12535	COG4977	sequence-specific DNA binding
IR208_12535	COG1917	Cupin 2, conserved barrel domain protein
IR208_12540	COG1874	Beta-galactosidase
IR208_12560	COG2271	Major facilitator Superfamily
IR208_12585	COG0697	spore germination
IR208_12600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IR208_12715	COG3527	Alpha-acetolactate decarboxylase
IR208_12720	COG0028	Belongs to the TPP enzyme family
IR208_12725	COG0583	DNA-binding transcription factor activity
IR208_12730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IR208_12735	COG0549	Belongs to the carbamate kinase family
IR208_12745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IR208_12755	COG0735	belongs to the Fur family
IR208_12770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IR208_12775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IR208_12780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR208_12785	COG1116	anion transmembrane transporter activity
IR208_12790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IR208_12795	COG2814	Major facilitator Superfamily
IR208_12815	COG1737	Transcriptional regulator
IR208_12820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_12820	COG1263	PTS System
IR208_12825	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IR208_12835	COG1132	(ABC) transporter
IR208_12840	COG3557	Belongs to the UPF0374 family
IR208_12855	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_12860	COG0583	DNA-binding transcription factor activity
IR208_12865	COG0069	glutamate synthase activity
IR208_12865	COG0067	glutamate synthase
IR208_12865	COG0070	glutamate synthase
IR208_12870	COG0493	'glutamate synthase
IR208_12885	COG1194	a g-specific adenine glycosylase
IR208_12890	COG1988	membrane-bound metal-dependent
IR208_12920	COG0159	tryptophan synthase activity
IR208_12930	COG0133	tryptophan synthase activity
IR208_12935	COG0134	indole-3-glycerol-phosphate synthase activity
IR208_12940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IR208_12945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IR208_12945	COG0512	Glutamine amidotransferase of anthranilate synthase
IR208_12955	COG0577	efflux transmembrane transporter activity
IR208_12960	COG0577	efflux transmembrane transporter activity
IR208_12960	COG1136	(ABC) transporter
IR208_12965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR208_12980	COG1131	(ABC) transporter
IR208_13015	COG2197	response regulator
IR208_13020	COG4585	Histidine kinase
IR208_13035	COG1012	belongs to the aldehyde dehydrogenase family
IR208_13035	COG1012	belongs to the aldehyde dehydrogenase family
IR208_13045	COG0058	SHG alpha-glucan phosphorylase activity
IR208_13050	COG0840	transmembrane signaling receptor activity
IR208_13055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IR208_13060	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IR208_13065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IR208_13080	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IR208_13085	COG0066	3-isopropylmalate dehydratase activity
IR208_13090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IR208_13100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IR208_13105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IR208_13110	COG0440	acetolactate synthase activity
IR208_13115	COG0028	Belongs to the TPP enzyme family
IR208_13120	COG0129	dihydroxy-acid dehydratase activity
IR208_13125	COG1114	Component of the transport system for branched-chain amino acids
IR208_13130	COG1366	Belongs to the anti-sigma-factor antagonist family
IR208_13160	COG0670	Belongs to the BI1 family
IR208_13165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IR208_13170	COG2223	nitrite transmembrane transporter activity
IR208_13175	COG3279	Response regulator of the LytR AlgR family
IR208_13180	COG3275	phosphorelay sensor kinase activity
IR208_13185	COG0252	asparaginase activity
IR208_13190	COG2132	Multicopper oxidase
IR208_13195	COG1309	transcriptional regulator
IR208_13200	COG1511	domain protein
IR208_13235	COG5278	phosphoserine phosphatase activity
IR208_13235	COG0840	transmembrane signaling receptor activity
IR208_13240	COG3739	integral membrane protein
IR208_13245	COG3655	Transcriptional regulator
IR208_13260	COG1823	symporter activity
IR208_13265	COG2839	Protein conserved in bacteria
IR208_13285	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
IR208_13310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IR208_13315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IR208_13320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IR208_13325	COG0840	transmembrane signaling receptor activity
IR208_13340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IR208_13345	COG1132	(ABC) transporter
IR208_13350	COG1846	Transcriptional regulator
IR208_13375	COG0798	PFAM Bile acid sodium symporter
IR208_13415	COG0024	Methionine aminopeptidase
IR208_13435	COG0464	growth
IR208_13575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IR208_13580	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IR208_13600	COG0387	Pfam Sodium calcium exchanger
IR208_13605	COG0477	Major facilitator Superfamily
IR208_13610	COG1295	ribonuclease BN
IR208_13615	COG4840	Belongs to the UPF0435 family
IR208_13620	COG0024	Methionine aminopeptidase
IR208_13625	COG0693	protein deglycase activity
IR208_13630	COG1360	Flagellar Motor Protein
IR208_13635	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IR208_13650	COG3189	MarR family transcriptional regulator
IR208_13660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IR208_13665	COG1607	acyl-coa hydrolase
IR208_13670	COG1077	Cell shape determining protein MreB Mrl
IR208_13675	COG2268	Band 7 protein
IR208_13680	COG1585	Membrane protein implicated in regulation of membrane protease activity
IR208_13685	COG0626	cystathionine gamma-synthase activity
IR208_13690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IR208_13695	COG1854	S-ribosylhomocysteine lyase activity
IR208_13705	COG0288	reversible hydration of carbon dioxide
IR208_13715	COG0860	N-Acetylmuramoyl-L-alanine amidase
IR208_13725	COG2197	response regulator
IR208_13745	COG4086	secreted protein
IR208_13750	COG0737	Belongs to the 5'-nucleotidase family
IR208_13770	COG3620	sequence-specific DNA binding
IR208_13775	COG3328	transposase activity
IR208_13795	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IR208_13800	COG1518	maintenance of DNA repeat elements
IR208_13855	COG1304	FMN binding
IR208_13860	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
IR208_13865	COG0166	Belongs to the GPI family
IR208_13870	COG0025	NhaP-type Na H and K H
IR208_13885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR208_13885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IR208_13885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IR208_13890	COG1349	DNA-binding transcription factor activity
IR208_13900	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IR208_13910	COG0561	phosphatase activity
IR208_13925	COG2814	Major facilitator Superfamily
IR208_13930	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IR208_13950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IR208_13955	COG0667	Aldo Keto reductase
IR208_13960	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
IR208_13965	COG1461	Dihydroxyacetone kinase
IR208_13970	COG2376	Dihydroxyacetone kinase
IR208_13980	COG0778	Nitroreductase
IR208_13985	COG1113	amino acid transport
IR208_13990	COG0730	response to heat
IR208_13995	COG2233	PERMEase
IR208_14010	COG2233	PERMEase
IR208_14020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IR208_14035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IR208_14040	COG1024	Enoyl-CoA hydratase
IR208_14045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IR208_14050	COG0511	ligase activity, forming carbon-carbon bonds
IR208_14055	COG0439	Biotin carboxylase
IR208_14060	COG1960	acyl-CoA dehydrogenase activity
IR208_14065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IR208_14080	COG1349	DNA-binding transcription factor activity
IR208_14090	COG2376	Dihydroxyacetone kinase
IR208_14100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IR208_14110	COG2271	Major facilitator Superfamily
IR208_14115	COG1250	3-hydroxyacyl-CoA dehydrogenase
IR208_14125	COG0698	ribose 5-phosphate isomerase
IR208_14130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IR208_14135	COG1494	fructose-1,6-bisphosphatase
IR208_14140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IR208_14145	COG3829	transcription factor binding
IR208_14150	COG0833	amino acid
IR208_14185	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IR208_14190	COG1140	nitrate reductase beta subunit
IR208_14200	COG2181	nitrate reductase activity
IR208_14205	COG2223	nitrite transmembrane transporter activity
IR208_14210	COG3588	fructose-bisphosphate aldolase
IR208_14215	COG1657	PFAM Prenyltransferase squalene oxidase
IR208_14220	COG1349	DNA-binding transcription factor activity
IR208_14255	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IR208_14280	COG1280	lysine exporter protein (LysE YggA)
IR208_14285	COG0386	Belongs to the glutathione peroxidase family
IR208_14290	COG2190	(PTS) system
IR208_14310	COG0582	viral genome integration into host DNA
IR208_14340	COG1328	CTP reductase activity
IR208_14350	COG1063	alcohol dehydrogenase
IR208_14355	COG1929	Belongs to the glycerate kinase type-1 family
IR208_14375	COG1879	ABC-type sugar transport system periplasmic component
IR208_14380	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR208_14385	COG1129	ABC transporter
IR208_14390	COG1869	D-ribose catabolic process
IR208_14395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR208_14400	COG1609	Transcriptional regulator
IR208_14440	COG4549	nuclear export factor GLE1
IR208_14445	COG2372	response to copper ion
IR208_14445	COG1276	copper resistance
IR208_14455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IR208_14460	COG1609	Transcriptional regulator
IR208_14475	COG5002	protein histidine kinase activity
IR208_14480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IR208_14495	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IR208_14505	COG2204	response regulator
IR208_14510	COG1606	tRNA processing
IR208_14515	COG2610	gluconate transmembrane transporter activity
IR208_14525	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IR208_14530	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IR208_14535	COG1691	(AIR) carboxylase
IR208_14555	COG1278	Cold shock
IR208_14560	COG0697	spore germination
IR208_14565	COG1472	Belongs to the glycosyl hydrolase 3 family
IR208_14575	COG3876	Protein conserved in bacteria
IR208_14590	COG1132	(ABC) transporter
IR208_14595	COG1132	(ABC) transporter
IR208_14605	COG1349	DNA-binding transcription factor activity
IR208_14610	COG1082	Xylose isomerase domain protein TIM barrel
IR208_14615	COG1082	Xylose isomerase domain protein TIM barrel
IR208_14620	COG0673	inositol 2-dehydrogenase activity
IR208_14625	COG2814	Major facilitator Superfamily
IR208_14630	COG1082	Xylose isomerase domain protein TIM barrel
IR208_14635	COG0673	inositol 2-dehydrogenase activity
IR208_14640	COG1082	Xylose isomerase domain protein TIM barrel
IR208_14645	COG0673	inositol 2-dehydrogenase activity
IR208_14650	COG1082	Xylose isomerase domain protein TIM barrel
IR208_14655	COG2814	Major facilitator Superfamily
IR208_14660	COG2814	Major facilitator Superfamily
IR208_14665	COG0191	fructose-bisphosphate aldolase activity
IR208_14670	COG3962	Belongs to the TPP enzyme family
IR208_14675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR208_14680	COG3718	enzyme involved in inositol metabolism
IR208_14685	COG1012	belongs to the aldehyde dehydrogenase family
IR208_14690	COG1388	LysM domain
IR208_14690	COG0791	NLP P60 protein
IR208_14710	COG2272	Belongs to the type-B carboxylesterase lipase family
IR208_14715	COG0154	amidase activity
IR208_14720	COG2814	Major facilitator Superfamily
IR208_14725	COG1012	belongs to the aldehyde dehydrogenase family
IR208_14755	COG3153	acetyltransferase
IR208_14755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IR208_14760	COG5583	Uncharacterized small protein (DUF2292)
IR208_14765	COG0431	NADPH-dependent FMN reductase
IR208_14770	COG1116	anion transmembrane transporter activity
IR208_14775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR208_14780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IR208_14785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IR208_14815	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IR208_14830	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IR208_14840	COG2390	Transcriptional regulator
IR208_14850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IR208_14860	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IR208_14875	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IR208_14880	COG1984	allophanate hydrolase subunit 2
IR208_14885	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IR208_14890	COG2814	Major facilitator Superfamily
IR208_14895	COG1764	response to oxidative stress
IR208_14900	COG1126	abc transporter atp-binding protein
IR208_14905	COG0765	amino acid transport
IR208_14910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR208_14920	COG0326	Molecular chaperone. Has ATPase activity
IR208_14940	COG0800	Aldolase
IR208_14955	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR208_14960	COG3716	PTS system mannose fructose sorbose family IID component
IR208_14970	COG0371	Dehydrogenase
IR208_14980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IR208_14985	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IR208_14990	COG1737	Transcriptional regulator
IR208_14995	COG0561	phosphatase activity
IR208_15010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR208_15025	COG1064	alcohol dehydrogenase
IR208_15060	COG2814	Major facilitator Superfamily
IR208_15065	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_15110	COG3716	PTS system mannose fructose sorbose family IID component
IR208_15165	COG3829	transcription factor binding
IR208_15210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IR208_15215	COG1597	lipid kinase activity
IR208_15235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IR208_15240	COG0154	amidase activity
IR208_15245	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IR208_15250	COG2224	Isocitrate lyase
IR208_15255	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IR208_15260	COG4851	CamS sex pheromone cAM373 precursor
IR208_15270	COG0210	DNA helicase
IR208_15275	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
IR208_15280	COG4496	protein, YerC YecD
IR208_15285	COG1470	cell adhesion involved in biofilm formation
IR208_15300	COG0151	Belongs to the GarS family
IR208_15305	COG0138	bifunctional purine biosynthesis protein purh
IR208_15310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IR208_15315	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IR208_15320	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IR208_15325	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IR208_15330	COG0047	phosphoribosylformylglycinamidine synthase activity
IR208_15335	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IR208_15345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IR208_15350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IR208_15355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IR208_15365	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
IR208_15370	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IR208_15390	COG1301	dicarboxylic acid transport
IR208_15400	COG3711	transcriptional antiterminator
IR208_15405	COG2252	PERMEase
IR208_15415	COG1132	(ABC) transporter
IR208_15420	COG2814	Major facilitator Superfamily
IR208_15425	COG2197	response regulator
IR208_15430	COG3850	Histidine kinase
IR208_15435	COG1131	(ABC) transporter
IR208_15445	COG0842	Transport permease protein
IR208_15470	COG0471	metal ion transport
IR208_15495	COG1131	(ABC) transporter
IR208_15500	COG1725	Transcriptional regulator
IR208_15505	COG1695	Transcriptional regulator
IR208_15510	COG3479	Phenolic acid decarboxylase
IR208_15515	COG2910	NAD(P)H-binding
IR208_15540	COG0425	Belongs to the sulfur carrier protein TusA family
IR208_15545	COG2391	methyltransferase activity
IR208_15555	COG1028	Short-chain dehydrogenase reductase Sdr
IR208_15575	COG1120	ATPase activity
IR208_15580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR208_15595	COG3620	sequence-specific DNA binding
IR208_15610	COG0519	Catalyzes the synthesis of GMP from XMP
IR208_15610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IR208_15615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IR208_15620	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IR208_15625	COG1335	isochorismatase
IR208_15635	COG4948	Mandelate Racemase Muconate Lactonizing
IR208_15645	COG0463	Glycosyl transferase, family 2
IR208_15650	COG2246	polysaccharide biosynthetic process
IR208_15655	COG0459	protein refolding
IR208_15660	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IR208_15665	COG1266	CAAX protease self-immunity
IR208_15675	COG0805	protein transport
IR208_15680	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IR208_15685	COG0488	(ABC) transporter
IR208_15790	COG3091	SprT-like family
IR208_15800	COG2183	response to ionizing radiation
IR208_15805	COG2208	phosphoserine phosphatase activity
IR208_15810	COG1191	sigma factor activity
IR208_15815	COG2172	sigma factor antagonist activity
IR208_15820	COG1366	Belongs to the anti-sigma-factor antagonist family
IR208_15825	COG2208	phosphoserine phosphatase activity
IR208_15830	COG2172	sigma factor antagonist activity
IR208_15835	COG1366	Belongs to the anti-sigma-factor antagonist family
IR208_15840	COG1366	Belongs to the anti-sigma-factor antagonist family
IR208_15845	COG2337	Toxic component of a toxin-antitoxin (TA) module
IR208_15850	COG0864	Transcriptional regulator
IR208_15860	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IR208_15865	COG0736	holo-[acyl-carrier-protein] synthase activity
IR208_15870	COG0705	Rhomboid family
IR208_15875	COG0513	Belongs to the DEAD box helicase family
IR208_15890	COG1280	lysine exporter protein (LysE YggA)
IR208_15895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IR208_15900	COG1609	Transcriptional regulator
IR208_15905	COG0366	Alpha amylase catalytic
IR208_15915	COG2182	Extracellular solute-binding protein
IR208_15920	COG1175	transmembrane transport
IR208_15925	COG3833	ABC-type maltose transport systems, permease component
IR208_15930	COG5521	maltodextrose utilization protein MalA
IR208_15935	COG1554	hydrolase, family 65, central catalytic
IR208_15945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IR208_15950	COG1181	Belongs to the D-alanine--D-alanine ligase family
IR208_15960	COG1253	flavin adenine dinucleotide binding
IR208_15965	COG0789	Transcriptional regulator
IR208_15970	COG1253	flavin adenine dinucleotide binding
IR208_15985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IR208_16000	COG0629	single-stranded DNA binding
IR208_16010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IR208_16015	COG4786	Flagellar basal body rod
IR208_16020	COG4786	Flagellar basal body rod
IR208_16025	COG1077	Cell shape determining protein MreB Mrl
IR208_16030	COG1609	Transcriptional regulator
IR208_16035	COG0739	heme binding
IR208_16040	COG2385	sporulation resulting in formation of a cellular spore
IR208_16045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IR208_16055	COG4836	Membrane
IR208_16060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IR208_16065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IR208_16070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IR208_16075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IR208_16080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IR208_16090	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IR208_16095	COG0356	it plays a direct role in the translocation of protons across the membrane
IR208_16105	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IR208_16110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IR208_16120	COG4475	Protein of unknown function (DUF436)
IR208_16125	COG0698	ribose 5-phosphate isomerase
IR208_16130	COG0840	transmembrane signaling receptor activity
IR208_16140	COG1971	Probably functions as a manganese efflux pump
IR208_16145	COG0009	L-threonylcarbamoyladenylate synthase
IR208_16160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IR208_16170	COG1435	thymidine kinase activity
IR208_16175	COG0254	rRNA binding
IR208_16180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IR208_16185	COG1494	fructose-1,6-bisphosphatase
IR208_16190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IR208_16195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IR208_16200	COG0191	fructose-bisphosphate aldolase activity
IR208_16205	COG2204	response regulator
IR208_16220	COG1131	(ABC) transporter
IR208_16225	COG1725	Transcriptional regulator
IR208_16230	COG0504	CTP synthase activity
IR208_16235	COG3343	RNA polymerase activity
IR208_16240	COG1136	(ABC) transporter
IR208_16255	COG1309	transcriptional regulator
IR208_16260	COG1960	acyl-CoA dehydrogenase activity
IR208_16265	COG1960	acyl-CoA dehydrogenase activity
IR208_16270	COG0183	Belongs to the thiolase family
IR208_16275	COG2181	nitrate reductase activity
IR208_16275	COG0247	lactate metabolic process
IR208_16280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IR208_16285	COG0018	arginyl-trna synthetase
IR208_16295	COG0010	Belongs to the arginase family
IR208_16300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IR208_16310	COG1994	Peptidase M50
IR208_16320	COG3465	dGTPase activity
IR208_16325	COG1078	dGTPase activity
IR208_16335	COG0095	Lipoate-protein ligase
IR208_16340	COG0280	phosphate acetyltransferase
IR208_16345	COG3253	May function as heme-dependent peroxidase
IR208_16355	COG2363	Small membrane protein
IR208_16365	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IR208_16400	COG4555	ABC transporter
IR208_16410	COG1122	ATPase activity
IR208_16425	COG0351	phosphomethylpyrimidine kinase
IR208_16440	COG0561	phosphatase activity
IR208_16445	COG0514	ATP-dependent DNA helicase (RecQ)
IR208_16450	COG1785	Belongs to the alkaline phosphatase family
IR208_16455	COG1737	Transcriptional regulator
IR208_16470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IR208_16480	COG1346	cytolysis
IR208_16485	COG1380	Effector of murein hydrolase LrgA
IR208_16490	COG0583	DNA-binding transcription factor activity
IR208_16495	COG0367	asparagine synthase
IR208_16515	COG2966	Psort location CytoplasmicMembrane, score
IR208_16520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IR208_16525	COG1966	Carbon starvation protein
IR208_16535	COG3275	phosphorelay sensor kinase activity
IR208_16540	COG1464	Belongs to the NlpA lipoprotein family
IR208_16545	COG2011	ABC-type metal ion transport system permease component
IR208_16550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IR208_16555	COG1119	ATPase activity
IR208_16570	COG0534	Mate efflux family protein
IR208_16575	COG1442	glycosyl transferase family 8
IR208_16580	COG2195	Cleaves the N-terminal amino acid of tripeptides
IR208_16585	COG2814	Major facilitator Superfamily
IR208_16595	COG0028	Belongs to the TPP enzyme family
IR208_16615	COG3842	ATPase activity
IR208_16635	COG0584	glycerophosphoryl diester phosphodiesterase
IR208_16670	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IR208_16690	COG2188	Transcriptional regulator
IR208_16695	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IR208_16700	COG1366	Belongs to the anti-sigma-factor antagonist family
IR208_16720	COG3457	Alanine racemase
IR208_16730	COG1126	abc transporter atp-binding protein
IR208_16740	COG0765	amino acid transport
IR208_16745	COG0579	oxidoreductase
IR208_16750	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IR208_16755	COG0732	type I restriction modification DNA specificity domain
IR208_16760	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IR208_16770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IR208_16775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IR208_16780	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IR208_16785	COG4853	Protein conserved in bacteria
IR208_16790	COG4863	YycH protein
IR208_16795	COG5002	protein histidine kinase activity
IR208_16800	COG0745	RESPONSE REGULATOR receiver
IR208_16815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IR208_16820	COG0305	Participates in initiation and elongation during chromosome replication
IR208_16825	COG0359	binds to the 23S rRNA
IR208_16830	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
IR208_16840	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IR208_16845	COG0629	single-stranded DNA binding
IR208_16850	COG0360	Binds together with S18 to 16S ribosomal RNA
IR208_16855	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IR208_16860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IR208_16860	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IR208_16865	COG0307	riboflavin synthase, alpha
IR208_16870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IR208_16870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IR208_16875	COG0012	GTP binding
IR208_16880	COG4481	Protein conserved in bacteria
IR208_16885	COG0668	transmembrane transport
IR208_16900	COG1475	DNA binding
IR208_16905	COG1192	Involved in chromosome partitioning
IR208_16910	COG1475	DNA binding
IR208_16915	COG0357	Ribosomal RNA small subunit methyltransferase G
IR208_16920	COG0445	tRNA wobble uridine modification
IR208_16925	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IR208_16930	COG1847	R3H domain protein
IR208_16935	COG0706	membrane insertase activity
IR208_16940	COG0594	ribonuclease P activity
IR208_16945	COG0230	Belongs to the bacterial ribosomal protein bL34 family