locus-tag	class	description
KNH48_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KNH48_00010	COG0592	DNA-directed DNA polymerase activity
KNH48_00015	COG2501	S4 domain
KNH48_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KNH48_00030	COG0187	DNA topoisomerase II activity
KNH48_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KNH48_00040	COG3437	response regulator, receiver
KNH48_00070	COG1982	Orn Lys Arg decarboxylase major
KNH48_00080	COG3870	Protein conserved in bacteria
KNH48_00085	COG1728	Protein conserved in bacteria
KNH48_00090	COG0470	DNA polymerase III
KNH48_00095	COG1774	PSP1 C-terminal conserved region
KNH48_00100	COG4467	Involved in initiation control of chromosome replication
KNH48_00105	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KNH48_00110	COG2827	Endonuclease containing a URI domain
KNH48_00115	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KNH48_00120	COG2002	toxin-antitoxin pair type II binding
KNH48_00130	COG0084	hydrolase, TatD family'
KNH48_00150	COG4466	Protein conserved in bacteria
KNH48_00170	COG0251	oxidation-reduction process
KNH48_00185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KNH48_00190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KNH48_00195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KNH48_00200	COG0193	aminoacyl-tRNA hydrolase activity
KNH48_00210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KNH48_00215	COG2002	toxin-antitoxin pair type II binding
KNH48_00220	COG2244	polysaccharide biosynthetic process
KNH48_00225	COG3956	TIGRFAM MazG family protein
KNH48_00230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KNH48_00250	COG1098	S1 RNA binding domain
KNH48_00265	COG2304	oxidoreductase activity
KNH48_00270	COG0515	serine threonine protein kinase
KNH48_00280	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KNH48_00285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KNH48_00290	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KNH48_00295	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KNH48_00300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KNH48_00310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KNH48_00315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KNH48_00400	COG0517	IMP dehydrogenase activity
KNH48_00400	COG0516	GMP reductase activity
KNH48_00425	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KNH48_00430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KNH48_00440	COG1428	Deoxynucleoside kinase
KNH48_00445	COG1428	Deoxynucleoside kinase
KNH48_00455	COG0590	tRNA wobble adenosine to inosine editing
KNH48_00465	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KNH48_00470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KNH48_00475	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KNH48_00520	COG3880	PFAM UvrB UvrC protein
KNH48_00525	COG3869	Catalyzes the specific phosphorylation of arginine residues in
KNH48_00530	COG0542	response to heat
KNH48_00535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KNH48_00540	COG4956	integral membrane protein (PIN domain superfamily)
KNH48_00550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KNH48_00565	COG0215	cysteine-tRNA ligase activity
KNH48_00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KNH48_00580	COG3688	RNA-binding protein containing a PIN domain
KNH48_00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KNH48_00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KNH48_00600	COG0250	Participates in transcription elongation, termination and antitermination
KNH48_00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KNH48_00610	COG0081	regulation of translation
KNH48_00615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KNH48_00625	COG2813	Specifically methylates the guanine in position
KNH48_00640	COG1358	cellular component organization or biogenesis
KNH48_00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KNH48_00650	COG0049	tRNA binding
KNH48_00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KNH48_00660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KNH48_00665	COG0051	transcription antitermination factor activity, RNA binding
KNH48_00675	COG0088	Forms part of the polypeptide exit tunnel
KNH48_00685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KNH48_00690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KNH48_00700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KNH48_00705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KNH48_00710	COG0255	Belongs to the universal ribosomal protein uL29 family
KNH48_00720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KNH48_00730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KNH48_00735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KNH48_00740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KNH48_00745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KNH48_00750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KNH48_00755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KNH48_00765	COG0200	Binds to the 23S rRNA
KNH48_00770	COG0201	protein transport
KNH48_00775	COG0563	adenylate kinase activity
KNH48_00780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KNH48_00785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KNH48_00790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KNH48_00795	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KNH48_00800	COG0202	RNA polymerase activity
KNH48_00805	COG0203	ribosomal protein L17
KNH48_00810	COG1122	ATPase activity
KNH48_00815	COG1122	ATPase activity
KNH48_00820	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KNH48_00835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KNH48_00840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KNH48_00850	COG2046	Belongs to the sulfate adenylyltransferase family
KNH48_00855	COG0529	Catalyzes the synthesis of activated sulfate
KNH48_00860	COG0833	amino acid
KNH48_00875	COG0489	protein tyrosine kinase activity
KNH48_00885	COG2194	sulfuric ester hydrolase activity
KNH48_00900	COG0726	polysaccharide deacetylase
KNH48_00910	COG1271	oxidase subunit
KNH48_00915	COG1294	oxidase, subunit
KNH48_00925	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KNH48_01000	COG1595	DNA-templated transcription, initiation
KNH48_01005	COG5662	AntiSigma factor
KNH48_01010	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KNH48_01015	COG4856	YbbR-like protein
KNH48_01020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KNH48_01065	COG0583	DNA-binding transcription factor activity
KNH48_01070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KNH48_01075	COG0840	transmembrane signaling receptor activity
KNH48_01090	COG1695	Transcriptional regulator
KNH48_01095	COG0840	transmembrane signaling receptor activity
KNH48_01145	COG3425	synthase
KNH48_01170	COG1125	glycine betaine transport
KNH48_01170	COG0517	IMP dehydrogenase activity
KNH48_01175	COG1174	glycine betaine transport
KNH48_01185	COG0716	FMN binding
KNH48_01190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KNH48_01195	COG2217	Heavy metal translocating P-type atpase
KNH48_01200	COG2217	Heavy metal translocating P-type atpase
KNH48_01205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KNH48_01215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KNH48_01220	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KNH48_01225	COG0463	Glycosyl transferase, family 2
KNH48_01260	COG2076	Multidrug Resistance protein
KNH48_01275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KNH48_01280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KNH48_01285	COG1120	ATPase activity
KNH48_01310	COG0217	transcriptional regulatory protein
KNH48_01315	COG1366	Belongs to the anti-sigma-factor antagonist family
KNH48_01335	COG1309	transcriptional regulator
KNH48_01350	COG1012	belongs to the aldehyde dehydrogenase family
KNH48_01355	COG5434	Belongs to the glycosyl hydrolase 28 family
KNH48_01370	COG0175	sulfate reduction
KNH48_01390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KNH48_01395	COG0371	Dehydrogenase
KNH48_01400	COG0318	PFAM AMP-dependent synthetase and ligase
KNH48_01415	COG0697	spore germination
KNH48_01440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KNH48_01450	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KNH48_01465	COG0702	epimerase
KNH48_01470	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KNH48_01470	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KNH48_01480	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KNH48_01505	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KNH48_01510	COG5577	PFAM Coat F domain
KNH48_01515	COG0667	Aldo Keto reductase
KNH48_01525	COG1113	amino acid transport
KNH48_01530	COG3104	oligopeptide transport
KNH48_01535	COG0833	amino acid
KNH48_01545	COG3842	ATPase activity
KNH48_01550	COG1176	ABC-type spermidine putrescine transport system, permease component I
KNH48_01555	COG1177	transmembrane transport
KNH48_01570	COG0531	amino acid
KNH48_01575	COG1556	Lactate utilization protein
KNH48_01580	COG1139	Iron-sulfur cluster binding protein
KNH48_01585	COG0247	lactate metabolic process
KNH48_01590	COG0531	amino acid
KNH48_01595	COG1979	alcohol dehydrogenase
KNH48_01600	COG0004	ammonium transporteR
KNH48_01610	COG2851	Citrate transporter
KNH48_01615	COG0463	Glycosyl transferase, family 2
KNH48_01620	COG3973	AAA domain
KNH48_01665	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KNH48_01670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KNH48_01675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KNH48_01680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KNH48_01685	COG1301	dicarboxylic acid transport
KNH48_01690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KNH48_01710	COG1902	pentaerythritol trinitrate reductase activity
KNH48_01725	COG0423	glycine-tRNA ligase activity
KNH48_01730	COG0531	amino acid
KNH48_01740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KNH48_01745	COG0628	permease
KNH48_01760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KNH48_01765	COG0765	amino acid transport
KNH48_01770	COG0765	amino acid transport
KNH48_01785	COG1733	regulation of RNA biosynthetic process
KNH48_01790	COG0586	Pfam SNARE associated Golgi protein
KNH48_01795	COG0586	Pfam SNARE associated Golgi protein
KNH48_01820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KNH48_01820	COG0646	methionine synthase
KNH48_01825	COG0646	methionine synthase
KNH48_01825	COG1410	methionine synthase
KNH48_01855	COG3944	biosynthesis protein
KNH48_01860	COG0489	protein tyrosine kinase activity
KNH48_01865	COG4464	protein tyrosine phosphatase activity
KNH48_01870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KNH48_01875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KNH48_01900	COG2244	polysaccharide biosynthetic process
KNH48_01955	COG1070	Carbohydrate kinase
KNH48_01985	COG1063	alcohol dehydrogenase
KNH48_01990	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KNH48_02005	COG4193	domain, Protein
KNH48_02025	COG2315	Protein conserved in bacteria
KNH48_02035	COG0658	competence protein
KNH48_02035	COG2333	competence protein COMEC
KNH48_02065	COG1316	TRANSCRIPTIONal
KNH48_02075	COG4989	oxidoreductase activity
KNH48_02085	COG2801	Transposase and inactivated derivatives
KNH48_02130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KNH48_02130	COG3711	transcriptional antiterminator
KNH48_02145	COG3711	transcriptional antiterminator
KNH48_02145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KNH48_02155	COG2211	Major facilitator Superfamily
KNH48_02155	COG2190	(PTS) system
KNH48_02165	COG2814	Major facilitator Superfamily
KNH48_02175	COG2814	Major facilitator Superfamily
KNH48_02190	COG1732	Glycine betaine
KNH48_02195	COG1174	glycine betaine transport
KNH48_02200	COG0517	IMP dehydrogenase activity
KNH48_02200	COG1125	glycine betaine transport
KNH48_02205	COG1510	regulation of RNA biosynthetic process
KNH48_02225	COG4297	protein containing double-stranded beta helix domain
KNH48_02235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KNH48_02240	COG2272	Belongs to the type-B carboxylesterase lipase family
KNH48_02245	COG0606	chelatase, subunit chli
KNH48_02260	COG0371	Dehydrogenase
KNH48_02270	COG0157	Belongs to the NadC ModD family
KNH48_02275	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KNH48_02280	COG1104	cysteine desulfurase activity
KNH48_02295	COG1131	(ABC) transporter
KNH48_02310	COG2116	formate transmembrane transporter activity
KNH48_02325	COG4720	Psort location CytoplasmicMembrane, score
KNH48_02360	COG0584	glycerophosphoryl diester phosphodiesterase
KNH48_02395	COG0531	amino acid
KNH48_02405	COG1620	l-lactate permease
KNH48_02410	COG2186	Transcriptional regulator
KNH48_02435	COG0473	3-isopropylmalate dehydrogenase activity
KNH48_02475	COG1447	Phosphotransferase system cellobiose-specific component IIA
KNH48_02490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KNH48_02490	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KNH48_02495	COG2723	6-phospho-beta-galactosidase activity
KNH48_02505	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KNH48_02515	COG0626	cystathionine gamma-synthase activity
KNH48_02540	COG1653	transport
KNH48_02545	COG2207	Transcriptional regulator
KNH48_02560	COG0604	alcohol dehydrogenase
KNH48_02565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KNH48_02570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KNH48_02590	COG1028	Short-chain dehydrogenase reductase Sdr
KNH48_02595	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KNH48_02605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KNH48_02615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KNH48_02620	COG1316	TRANSCRIPTIONal
KNH48_02630	COG2801	Transposase and inactivated derivatives
KNH48_02635	COG2801	Transposase and inactivated derivatives
KNH48_02640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KNH48_02645	COG1554	hydrolase, family 65, central catalytic
KNH48_02655	COG1609	Transcriptional regulator
KNH48_02670	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KNH48_02685	COG1388	LysM domain
KNH48_02685	COG3584	3D domain protein
KNH48_02710	COG0011	TIGRFAM Protein of
KNH48_02715	COG2706	6-phosphogluconolactonase activity
KNH48_02725	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KNH48_02725	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KNH48_02730	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KNH48_02730	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KNH48_02740	COG3715	PTS system
KNH48_02745	COG3716	PTS system mannose fructose sorbose family IID component
KNH48_02760	COG2079	MmgE PrpD family protein
KNH48_02765	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KNH48_02775	COG0154	amidase activity
KNH48_02785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KNH48_02790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KNH48_02795	COG1116	anion transmembrane transporter activity
KNH48_02800	COG0083	homoserine kinase activity
KNH48_02805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KNH48_02810	COG0460	homoserine dehydrogenase
KNH48_02815	COG0010	Belongs to the arginase family
KNH48_02825	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KNH48_02830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KNH48_02840	COG4145	pantothenate transmembrane transporter activity
KNH48_02855	COG1012	belongs to the aldehyde dehydrogenase family
KNH48_02855	COG1454	alcohol dehydrogenase
KNH48_02870	COG0791	NLP P60 protein
KNH48_02870	COG1388	LysM domain
KNH48_02875	COG0024	Methionine aminopeptidase
KNH48_02880	COG1268	BioY protein
KNH48_02890	COG0318	PFAM AMP-dependent synthetase and ligase
KNH48_02895	COG1960	acyl-CoA dehydrogenase activity
KNH48_02905	COG2746	aminoglycoside 3-N-acetyltransferase activity
KNH48_02915	COG0589	response to stress
KNH48_02930	COG0535	radical SAM domain protein
KNH48_02935	COG2211	Major facilitator Superfamily
KNH48_02940	COG1609	Transcriptional regulator
KNH48_02950	COG0561	phosphatase activity
KNH48_02980	COG0431	NADPH-dependent FMN reductase
KNH48_02990	COG0420	3'-5' exonuclease activity
KNH48_02995	COG4717	serine-type aminopeptidase activity
KNH48_03000	COG1250	3-hydroxyacyl-CoA dehydrogenase
KNH48_03005	COG0534	Mate efflux family protein
KNH48_03010	COG1664	Polymer-forming cytoskeletal
KNH48_03025	COG0436	Aminotransferase
KNH48_03030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KNH48_03040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KNH48_03080	COG1090	epimerase
KNH48_03085	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KNH48_03110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KNH48_03130	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KNH48_03145	COG1960	acyl-CoA dehydrogenase activity
KNH48_03160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KNH48_03165	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
KNH48_03175	COG1609	Transcriptional regulator
KNH48_03190	COG2996	Protein conserved in bacteria
KNH48_03195	COG0346	lactoylglutathione lyase activity
KNH48_03215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KNH48_03225	COG2188	Transcriptional regulator
KNH48_03230	COG0791	NLP P60 protein
KNH48_03230	COG1388	LysM domain
KNH48_03240	COG0768	penicillin binding
KNH48_03250	COG1739	Uncharacterized protein family UPF0029
KNH48_03260	COG2197	response regulator
KNH48_03265	COG0531	amino acid
KNH48_03270	COG1307	EDD domain protein, DegV family
KNH48_03280	COG1040	competence protein
KNH48_03290	COG2747	anti-sigma28 factor FlgM
KNH48_03300	COG4786	Flagellar basal body rod
KNH48_03300	COG1256	bacterial-type flagellum assembly
KNH48_03305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KNH48_03315	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KNH48_03320	COG0653	protein targeting
KNH48_03335	COG1067	ATP-dependent peptidase activity
KNH48_03345	COG2094	Belongs to the DNA glycosylase MPG family
KNH48_03355	COG1334	flagellar protein FlaG
KNH48_03365	COG1516	flagellar protein fliS
KNH48_03385	COG0653	protein targeting
KNH48_03395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KNH48_03405	COG2884	Cell division ATP-binding protein ftsE
KNH48_03410	COG2177	Part of the ABC transporter FtsEX involved in
KNH48_03415	COG0739	heme binding
KNH48_03435	COG3409	Peptidoglycan-binding domain 1 protein
KNH48_03435	COG0793	Belongs to the peptidase S41A family
KNH48_03445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KNH48_03450	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KNH48_03455	COG4605	iron ion homeostasis
KNH48_03460	COG4604	ABC transporter, ATP-binding protein
KNH48_03480	COG0745	RESPONSE REGULATOR receiver
KNH48_03485	COG5002	protein histidine kinase activity
KNH48_03500	COG0573	inorganic phosphate transmembrane transporter activity
KNH48_03505	COG0581	inorganic phosphate transmembrane transporter activity
KNH48_03515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KNH48_03520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KNH48_03545	COG0556	nucleotide-excision repair
KNH48_03550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KNH48_03555	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KNH48_03565	COG0463	Glycosyl transferase, family 2
KNH48_03575	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KNH48_03580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KNH48_03585	COG1682	transport, permease protein
KNH48_03590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KNH48_03590	COG1215	transferase activity, transferring glycosyl groups
KNH48_03595	COG3595	metallopeptidase activity
KNH48_03605	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KNH48_03615	COG0546	phosphoglycolate phosphatase activity
KNH48_03620	COG0110	maltose O-acetyltransferase activity
KNH48_03625	COG0457	Tetratricopeptide repeat
KNH48_03630	COG0492	ferredoxin-NADP+ reductase activity
KNH48_03635	COG1051	belongs to the nudix hydrolase family
KNH48_03640	COG1660	Displays ATPase and GTPase activities
KNH48_03650	COG1481	regulation of sporulation
KNH48_03655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KNH48_03690	COG3842	ATPase activity
KNH48_03695	COG2508	Transcriptional regulator
KNH48_03705	COG0189	ligase activity
KNH48_03710	COG0189	ligase activity
KNH48_03720	COG4399	Belongs to the UPF0754 family
KNH48_03730	COG0561	phosphatase activity
KNH48_03735	COG1024	Enoyl-CoA hydratase
KNH48_03745	COG0861	Integral membrane protein TerC family
KNH48_03750	COG0701	Predicted permease
KNH48_03755	COG3689	TIGRFAM TIGR03943 family protein
KNH48_03760	COG0420	3'-5' exonuclease activity
KNH48_03780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KNH48_03795	COG1846	Transcriptional regulator
KNH48_03815	COG0537	adenosine 5'-monophosphoramidase activity
KNH48_03820	COG1131	(ABC) transporter
KNH48_03825	COG4473	ABC transporter
KNH48_03830	COG1473	amidohydrolase
KNH48_03835	COG3069	C4-dicarboxylate transmembrane transporter activity
KNH48_03840	COG2329	Antibiotic biosynthesis monooxygenase
KNH48_03850	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KNH48_03855	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KNH48_03860	COG1309	transcriptional regulator
KNH48_03885	COG0697	spore germination
KNH48_03890	COG1012	belongs to the aldehyde dehydrogenase family
KNH48_03895	COG1999	signal sequence binding
KNH48_03910	COG0095	Lipoate-protein ligase
KNH48_03915	COG0318	PFAM AMP-dependent synthetase and ligase
KNH48_03920	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KNH48_03930	COG0501	Belongs to the peptidase M48B family
KNH48_03940	COG4903	ComK protein
KNH48_03950	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KNH48_03955	COG1074	ATP-dependent DNA helicase activity
KNH48_03990	COG2311	Membrane
KNH48_04015	COG1307	EDD domain protein, DegV family
KNH48_04030	COG0561	phosphatase activity
KNH48_04035	COG2151	metal-sulfur cluster biosynthetic enzyme
KNH48_04065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KNH48_04070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KNH48_04085	COG4608	Belongs to the ABC transporter superfamily
KNH48_04090	COG0601	transmembrane transport
KNH48_04110	COG0180	Tryptophanyl-tRNA synthetase
KNH48_04120	COG4166	transmembrane transport
KNH48_04125	COG0601	transmembrane transport
KNH48_04130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KNH48_04140	COG4608	Belongs to the ABC transporter superfamily
KNH48_04145	COG1393	Belongs to the ArsC family
KNH48_04150	COG4862	establishment of competence for transformation
KNH48_04155	COG4469	Competence protein
KNH48_04160	COG1164	Oligoendopeptidase f
KNH48_04170	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KNH48_04175	COG2346	COG2346, Truncated hemoglobins
KNH48_04180	COG0741	lytic transglycosylase activity
KNH48_04185	COG4116	CYTH
KNH48_04195	COG2357	RelA SpoT domain protein
KNH48_04205	COG0564	pseudouridine synthase activity
KNH48_04210	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KNH48_04215	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KNH48_04255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KNH48_04280	COG2153	protein acetylation
KNH48_04290	COG2382	esterase
KNH48_04315	COG1940	carbohydrate kinase activity
KNH48_04330	COG1668	transmembrane transport
KNH48_04340	COG3579	cysteine-type endopeptidase activity
KNH48_04365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KNH48_04375	COG2059	Chromate
KNH48_04380	COG1522	sequence-specific DNA binding
KNH48_04410	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KNH48_04425	COG0640	Transcriptional regulator
KNH48_04430	COG2814	Major facilitator Superfamily
KNH48_04445	COG0477	Major facilitator Superfamily
KNH48_04455	COG1959	2 iron, 2 sulfur cluster binding
KNH48_04465	COG0730	response to heat
KNH48_04470	COG0783	Belongs to the Dps family
KNH48_04480	COG0673	inositol 2-dehydrogenase activity
KNH48_04485	COG3852	Histidine kinase
KNH48_04490	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KNH48_04520	COG5002	protein histidine kinase activity
KNH48_04525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KNH48_04540	COG0542	response to heat
KNH48_04545	COG3949	Membrane
KNH48_04555	COG4873	Protein conserved in bacteria
KNH48_04565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KNH48_04580	COG2084	Dehydrogenase
KNH48_04585	COG0436	Aminotransferase
KNH48_04590	COG0784	Response regulator, receiver
KNH48_04590	COG0835	chemotaxis
KNH48_04600	COG1033	growth of symbiont in host cell
KNH48_04600	COG2409	Drug exporters of the RND superfamily
KNH48_04650	COG4703	Protein of unknown function (DUF1797)
KNH48_04655	COG0517	IMP dehydrogenase activity
KNH48_04660	COG0583	DNA-binding transcription factor activity
KNH48_04665	COG2171	N-acyltransferase activity
KNH48_04670	COG1473	amidohydrolase
KNH48_04680	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KNH48_04725	COG1982	Orn Lys Arg decarboxylase major
KNH48_04750	COG0483	inositol monophosphate 1-phosphatase activity
KNH48_04760	COG1217	gtp-binding protein TYPA
KNH48_04770	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KNH48_04775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KNH48_04780	COG4838	Belongs to the UPF0358 family
KNH48_04785	COG0772	Belongs to the SEDS family
KNH48_04790	COG1612	heme a metabolic process
KNH48_04795	COG0109	protoheme IX farnesyltransferase activity
KNH48_04800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KNH48_04800	COG2010	Cytochrome c
KNH48_04815	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KNH48_04820	COG3336	cytochrome c oxidase
KNH48_04830	COG2340	Cysteine-rich secretory protein family
KNH48_04855	COG3679	Belongs to the UPF0342 family
KNH48_04860	COG4471	UPF0298 protein
KNH48_04870	COG0742	ribosomal rna small subunit methyltransferase
KNH48_04875	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KNH48_04880	COG3314	Sporulation integral membrane protein YlbJ
KNH48_04885	COG1752	Esterase of the alpha-beta hydrolase superfamily
KNH48_04890	COG3480	Lon protease (S16) C-terminal proteolytic domain
KNH48_04895	COG1323	Belongs to the UPF0348 family
KNH48_04900	COG1399	metal-binding, possibly nucleic acid-binding protein
KNH48_04905	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KNH48_04915	COG0454	-acetyltransferase
KNH48_04920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KNH48_04930	COG2001	Belongs to the MraZ family
KNH48_04935	COG0275	rRNA processing
KNH48_04940	COG4839	cell division protein FtsL
KNH48_04965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KNH48_04970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KNH48_04980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KNH48_04985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KNH48_04990	COG0849	cell division
KNH48_04995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KNH48_05005	COG1191	sigma factor activity
KNH48_05010	COG1191	sigma factor activity
KNH48_05015	COG1873	PFAM PRC-barrel domain
KNH48_05030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KNH48_05035	COG1799	cell septum assembly
KNH48_05040	COG0762	integral membrane protein
KNH48_05045	COG2302	S4 RNA-binding domain
KNH48_05050	COG3599	regulation of cell shape
KNH48_05070	COG0564	pseudouridine synthase activity
KNH48_05075	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KNH48_05080	COG0540	Belongs to the ATCase OTCase family
KNH48_05085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KNH48_05100	COG0543	2 iron, 2 sulfur cluster binding
KNH48_05105	COG0167	dihydroorotate dehydrogenase activity
KNH48_05110	COG0284	orotidine-5'-phosphate decarboxylase activity
KNH48_05115	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KNH48_05140	COG1803	Methylglyoxal synthase
KNH48_05160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KNH48_05165	COG0477	Major facilitator Superfamily
KNH48_05170	COG0477	Major facilitator Superfamily
KNH48_05175	COG0628	permease
KNH48_05190	COG0720	synthase
KNH48_05210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KNH48_05215	COG1561	YicC-like family, N-terminal region
KNH48_05220	COG2052	Domain of unknown function (DUF370)
KNH48_05225	COG0194	GDP metabolic process
KNH48_05230	COG1758	RNA polymerase activity
KNH48_05235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KNH48_05240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KNH48_05245	COG0242	peptide deformylase activity
KNH48_05250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KNH48_05255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KNH48_05255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KNH48_05260	COG0631	protein serine/threonine phosphatase activity
KNH48_05270	COG1162	GTPase activity
KNH48_05275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KNH48_05280	COG1564	THIamine pyrophosphokinase
KNH48_05290	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KNH48_05295	COG1302	Protein conserved in bacteria
KNH48_05300	COG1461	Dihydroxyacetone kinase
KNH48_05305	COG1760	l-serine dehydratase
KNH48_05310	COG1760	l-serine dehydratase
KNH48_05315	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KNH48_05320	COG1349	DNA-binding transcription factor activity
KNH48_05325	COG0416	fatty acid biosynthetic process
KNH48_05335	COG1028	Short-chain dehydrogenase reductase Sdr
KNH48_05345	COG0571	ribonuclease III activity
KNH48_05350	COG1196	nuclear chromosome segregation
KNH48_05355	COG0552	protein localization to endoplasmic reticulum
KNH48_05360	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
KNH48_05365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KNH48_05375	COG1837	Belongs to the UPF0109 family
KNH48_05385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KNH48_05390	COG0336	Belongs to the RNA methyltransferase TrmD family
KNH48_05405	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KNH48_05420	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KNH48_05425	COG0045	succinate-CoA ligase (ADP-forming) activity
KNH48_05430	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KNH48_05440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KNH48_05445	COG4974	Belongs to the 'phage' integrase family
KNH48_05450	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KNH48_05460	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KNH48_05465	COG1815	bacterial-type flagellum-dependent cell motility
KNH48_05470	COG1558	bacterial-type flagellum-dependent cell motility
KNH48_05475	COG1677	Flagellar hook-basal body complex protein FliE
KNH48_05480	COG1766	The M ring may be actively involved in energy transduction
KNH48_05485	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KNH48_05490	COG1317	bacterial-type flagellum organization
KNH48_05495	COG1157	protein secretion by the type III secretion system
KNH48_05500	COG2882	bacterial-type flagellum organization
KNH48_05515	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KNH48_05525	COG4786	Flagellar basal body rod
KNH48_05535	COG1580	Controls the rotational direction of flagella during chemotaxis
KNH48_05540	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KNH48_05545	COG1776	CheC inhibitor of MCP methylation
KNH48_05545	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KNH48_05550	COG2201	protein-glutamate methylesterase activity
KNH48_05555	COG3190	flagellar
KNH48_05560	COG1338	Plays a role in the flagellum-specific transport system
KNH48_05565	COG1987	bacterial-type flagellum assembly
KNH48_05570	COG1684	flagellar biosynthetic protein fliR
KNH48_05575	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KNH48_05580	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KNH48_05585	COG1419	protein localization to endoplasmic reticulum
KNH48_05590	COG0455	bacterial-type flagellum organization
KNH48_05595	COG2201	protein-glutamate methylesterase activity
KNH48_05600	COG0643	Histidine kinase
KNH48_05600	COG2198	Histidine kinase
KNH48_05605	COG0835	chemotaxis
KNH48_05610	COG1776	CheC inhibitor of MCP methylation
KNH48_05615	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
KNH48_05620	COG1191	sigma factor activity
KNH48_05630	COG0052	Belongs to the universal ribosomal protein uS2 family
KNH48_05635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KNH48_05640	COG0528	UMP kinase activity
KNH48_05645	COG0233	cytoplasmic translational termination
KNH48_05650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KNH48_05655	COG4589	Belongs to the CDS family
KNH48_05660	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KNH48_05665	COG0750	zinc metalloprotease
KNH48_05670	COG0442	prolyl-tRNA aminoacylation
KNH48_05675	COG2176	DNA-directed DNA polymerase activity
KNH48_05680	COG0779	Required for maturation of 30S ribosomal subunits
KNH48_05685	COG0195	Participates in both transcription termination and antitermination
KNH48_05690	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KNH48_05695	COG1358	cellular component organization or biogenesis
KNH48_05705	COG1550	Protein conserved in bacteria
KNH48_05710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KNH48_05715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KNH48_05720	COG0196	riboflavin kinase activity
KNH48_05725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KNH48_05730	COG1185	polyribonucleotide nucleotidyltransferase activity
KNH48_05740	COG0612	Peptidase, M16
KNH48_05745	COG1873	PFAM PRC-barrel domain
KNH48_05750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KNH48_05755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KNH48_05760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KNH48_05765	COG0527	aspartate kinase activity
KNH48_05775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KNH48_05780	COG0740	serine-type endopeptidase activity
KNH48_05790	COG4980	gas vesicle protein
KNH48_05790	COG1674	ftsk spoiiie
KNH48_05795	COG1744	ABC transporter substrate-binding protein PnrA-like
KNH48_05800	COG3845	ABC transporter
KNH48_05805	COG4603	Belongs to the binding-protein-dependent transport system permease family
KNH48_05810	COG1079	Belongs to the binding-protein-dependent transport system permease family
KNH48_05815	COG0612	Peptidase, M16
KNH48_05820	COG0612	Peptidase, M16
KNH48_05825	COG0300	oxidoreductase activity
KNH48_05840	COG1426	Protein conserved in bacteria
KNH48_05845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KNH48_05850	COG1546	Belongs to the CinA family
KNH48_05850	COG1058	Belongs to the CinA family
KNH48_05860	COG1418	mRNA catabolic process
KNH48_05865	COG1692	metallophosphoesterase
KNH48_05870	COG2359	stage V sporulation protein S
KNH48_05875	COG0826	peptidase U32
KNH48_05880	COG0826	peptidase U32
KNH48_05890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KNH48_05895	COG4550	Control of competence regulator ComK, YlbF/YmcA
KNH48_05910	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KNH48_05925	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KNH48_05935	COG0464	growth
KNH48_05940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KNH48_05945	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KNH48_05950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KNH48_05975	COG1321	iron dependent repressor
KNH48_05990	COG0488	(ABC) transporter
KNH48_05995	COG1413	lyase activity
KNH48_06010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KNH48_06015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KNH48_06020	COG1272	protein, Hemolysin III
KNH48_06025	COG2755	lipolytic protein G-D-S-L family
KNH48_06035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KNH48_06035	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
KNH48_06040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KNH48_06045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KNH48_06055	COG0840	transmembrane signaling receptor activity
KNH48_06060	COG4479	Belongs to the UPF0346 family
KNH48_06080	COG1876	peptidase activity
KNH48_06085	COG3409	Peptidoglycan-binding domain 1 protein
KNH48_06085	COG0793	Belongs to the peptidase S41A family
KNH48_06090	COG1846	Transcriptional regulator
KNH48_06095	COG2340	Cysteine-rich secretory protein family
KNH48_06100	COG0534	Mate efflux family protein
KNH48_06115	COG3285	dna ligase
KNH48_06115	COG1793	dna ligase
KNH48_06120	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KNH48_06125	COG0671	phosphoesterase, PA-phosphatase related
KNH48_06130	COG1368	sulfuric ester hydrolase activity
KNH48_06135	COG1331	Highly conserved protein containing a thioredoxin domain
KNH48_06140	COG2814	Major facilitator Superfamily
KNH48_06145	COG0745	RESPONSE REGULATOR receiver
KNH48_06160	COG0567	Dehydrogenase, E1 component
KNH48_06170	COG1012	belongs to the aldehyde dehydrogenase family
KNH48_06195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KNH48_06210	COG2135	peptidase activity
KNH48_06220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KNH48_06225	COG0517	IMP dehydrogenase activity
KNH48_06225	COG0516	GMP reductase activity
KNH48_06230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KNH48_06230	COG0723	plastoquinol--plastocyanin reductase activity
KNH48_06235	COG3584	3D domain protein
KNH48_06235	COG1388	LysM domain
KNH48_06240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KNH48_06245	COG1113	amino acid transport
KNH48_06250	COG0598	Magnesium transport protein CorA
KNH48_06260	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KNH48_06265	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KNH48_06275	COG0131	Imidazoleglycerol-phosphate dehydratase
KNH48_06280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KNH48_06310	COG2962	Rard protein
KNH48_06315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KNH48_06320	COG0569	domain protein
KNH48_06350	COG2807	transmembrane transport
KNH48_06355	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KNH48_06365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KNH48_06375	COG1278	Cold shock
KNH48_06385	COG3634	alkyl hydroperoxide reductase activity
KNH48_06400	COG0577	efflux transmembrane transporter activity
KNH48_06405	COG1136	(ABC) transporter
KNH48_06410	COG0642	Histidine kinase
KNH48_06415	COG0745	RESPONSE REGULATOR receiver
KNH48_06440	COG0640	Transcriptional regulator
KNH48_06445	COG2814	Major facilitator Superfamily
KNH48_06450	COG5039	Polysaccharide pyruvyl transferase
KNH48_06475	COG0477	Major facilitator Superfamily
KNH48_06485	COG1132	(ABC) transporter
KNH48_06490	COG1132	(ABC) transporter
KNH48_06500	COG1380	Effector of murein hydrolase LrgA
KNH48_06505	COG1346	cytolysis
KNH48_06510	COG0318	PFAM AMP-dependent synthetase and ligase
KNH48_06535	COG2309	aminopeptidase activity
KNH48_06545	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KNH48_06575	COG4841	protein insertion into membrane
KNH48_06580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KNH48_06585	COG1832	CoA-binding protein
KNH48_06590	COG0187	DNA topoisomerase II activity
KNH48_06595	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KNH48_06610	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KNH48_06640	COG2070	2-Nitropropane dioxygenase
KNH48_06645	COG0681	Belongs to the peptidase S26 family
KNH48_06675	COG0456	acetyltransferase
KNH48_06680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KNH48_06690	COG1028	Short-chain dehydrogenase reductase Sdr
KNH48_06695	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KNH48_06700	COG0351	phosphomethylpyrimidine kinase
KNH48_06705	COG0352	thiamine-phosphate diphosphorylase activity
KNH48_06715	COG2258	MOSC domain
KNH48_06745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KNH48_06750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KNH48_06765	COG2045	Belongs to the ComB family
KNH48_06770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KNH48_06775	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KNH48_06790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KNH48_06795	COG0697	spore germination
KNH48_06800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KNH48_06805	COG0022	dehydrogenase e1 component
KNH48_06815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KNH48_06820	COG3284	Transcriptional regulator
KNH48_06825	COG3264	Mechanosensitive ion channel
KNH48_06825	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KNH48_06840	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KNH48_06865	COG0561	phosphatase activity
KNH48_06870	COG2322	membrane
KNH48_06885	COG0039	L-malate dehydrogenase activity
KNH48_06905	COG0640	Transcriptional regulator
KNH48_06910	COG2217	Heavy metal translocating P-type atpase
KNH48_06920	COG4974	Belongs to the 'phage' integrase family
KNH48_06925	COG1028	Short-chain dehydrogenase reductase Sdr
KNH48_06935	COG3773	Cell wall hydrolase
KNH48_06940	COG0708	Exodeoxyribonuclease III
KNH48_06950	COG0297	glycogen (starch) synthase activity
KNH48_06960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KNH48_06965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KNH48_06985	COG1247	-acetyltransferase
KNH48_06990	COG0494	nUDIX hydrolase
KNH48_06995	COG1914	H( )-stimulated, divalent metal cation uptake system
KNH48_07000	COG0783	Belongs to the Dps family
KNH48_07010	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KNH48_07015	COG1131	(ABC) transporter
KNH48_07040	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KNH48_07050	COG2030	dehydratase
KNH48_07055	COG1028	Short-chain dehydrogenase reductase Sdr
KNH48_07070	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
KNH48_07075	COG0709	Synthesizes selenophosphate from selenide and ATP
KNH48_07090	COG0701	Predicted permease
KNH48_07095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KNH48_07100	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KNH48_07110	COG1252	NADH dehydrogenase
KNH48_07125	COG4990	cell redox homeostasis
KNH48_07130	COG0789	Transcriptional regulator
KNH48_07155	COG0436	Aminotransferase
KNH48_07160	COG0165	Argininosuccinate lyase
KNH48_07165	COG0137	argininosuccinate synthase activity
KNH48_07170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KNH48_07180	COG0505	Belongs to the CarA family
KNH48_07190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KNH48_07195	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KNH48_07200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KNH48_07245	COG1619	proteins homologs of microcin C7 resistance protein MccF
KNH48_07255	COG0204	Acyl-transferase
KNH48_07265	COG4846	Membrane protein involved in cytochrome C biogenesis
KNH48_07270	COG2201	protein-glutamate methylesterase activity
KNH48_07275	COG0785	Cytochrome C biogenesis protein
KNH48_07280	COG3763	UPF0154 protein
KNH48_07295	COG4224	UPF0291 protein
KNH48_07300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KNH48_07315	COG0174	glutamine synthetase
KNH48_07320	COG0789	Transcriptional regulator
KNH48_07325	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KNH48_07340	COG2233	PERMEase
KNH48_07350	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KNH48_07355	COG0116	Belongs to the methyltransferase superfamily
KNH48_07370	COG4474	Belongs to the UPF0398 family
KNH48_07390	COG0071	Belongs to the small heat shock protein (HSP20) family
KNH48_07415	COG3331	DNA recombination
KNH48_07420	COG4499	WXG100 protein secretion system (Wss), protein YukC
KNH48_07420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KNH48_07425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KNH48_07430	COG3935	DnaD domain protein
KNH48_07435	COG0017	Asparaginyl-tRNA synthetase
KNH48_07450	COG1199	ATP-dependent helicase activity
KNH48_07450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KNH48_07455	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KNH48_07460	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KNH48_07480	COG0438	transferase activity, transferring glycosyl groups
KNH48_07485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KNH48_07495	COG1694	Mazg nucleotide pyrophosphohydrolase
KNH48_07510	COG2738	Putative neutral zinc metallopeptidase
KNH48_07520	COG4347	Protein of unknown function (DUF1405)
KNH48_07530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KNH48_07545	COG5582	Belongs to the UPF0302 family
KNH48_07550	COG0457	Tetratricopeptide repeat
KNH48_07555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KNH48_07565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KNH48_07570	COG4401	Chorismate mutase type I
KNH48_07575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KNH48_07580	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KNH48_07585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KNH48_07590	COG0105	UTP biosynthetic process
KNH48_07595	COG0142	geranyltranstransferase activity
KNH48_07600	COG2226	methyltransferase
KNH48_07615	COG0776	regulation of translation
KNH48_07620	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KNH48_07640	COG1160	GTP binding
KNH48_07655	COG0539	negative regulation of cytoplasmic translation
KNH48_07660	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KNH48_07665	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
KNH48_07670	COG2959	enzyme of heme biosynthesis
KNH48_07675	COG3409	Peptidoglycan-binding domain 1 protein
KNH48_07675	COG3773	Cell wall hydrolase
KNH48_07680	COG2339	peptidase activity
KNH48_07690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KNH48_07700	COG1408	metallophosphoesterase
KNH48_07715	COG3546	catalase activity
KNH48_07730	COG1266	CAAX protease self-immunity
KNH48_07735	COG0514	ATP-dependent DNA helicase (RecQ)
KNH48_07745	COG1141	Ferredoxin
KNH48_07750	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KNH48_07755	COG1196	nuclear chromosome segregation
KNH48_07755	COG0741	lytic transglycosylase activity
KNH48_07755	COG0739	heme binding
KNH48_07760	COG5002	protein histidine kinase activity
KNH48_07765	COG0745	RESPONSE REGULATOR receiver
KNH48_07770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KNH48_07775	COG1333	cytochrome c biogenesis protein
KNH48_07780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KNH48_07785	COG1187	pseudouridine synthase activity
KNH48_07790	COG0700	Nucleoside recognition
KNH48_07795	COG2715	membrane protein required for spore maturation
KNH48_07800	COG1686	Belongs to the peptidase S11 family
KNH48_07805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KNH48_07830	COG0697	spore germination
KNH48_07850	COG1191	sigma factor activity
KNH48_07870	COG4974	Belongs to the 'phage' integrase family
KNH48_07880	COG0735	belongs to the Fur family
KNH48_07885	COG1300	Membrane
KNH48_07890	COG1379	DNA repair
KNH48_07905	COG0667	Aldo Keto reductase
KNH48_07915	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
KNH48_07920	COG3853	Toxic anion resistance protein (TelA)
KNH48_07925	COG1073	alpha beta
KNH48_07930	COG3858	chitin binding
KNH48_07930	COG1388	LysM domain
KNH48_07940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KNH48_07945	COG0300	oxidoreductase activity
KNH48_07950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KNH48_07960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KNH48_07975	COG2195	Cleaves the N-terminal amino acid of tripeptides
KNH48_07985	COG1376	ErfK ybiS ycfS ynhG family protein
KNH48_07995	COG1105	Belongs to the carbohydrate kinase PfkB family
KNH48_08000	COG0508	dehydrogenase complex catalyzes the overall conversion of
KNH48_08005	COG0022	dehydrogenase e1 component
KNH48_08010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KNH48_08015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KNH48_08025	COG3829	transcription factor binding
KNH48_08025	COG3290	protein histidine kinase activity
KNH48_08040	COG0584	glycerophosphoryl diester phosphodiesterase
KNH48_08045	COG0745	RESPONSE REGULATOR receiver
KNH48_08050	COG0750	zinc metalloprotease
KNH48_08055	COG0497	DNA recombination
KNH48_08065	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KNH48_08070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KNH48_08095	COG1570	exodeoxyribonuclease VII activity
KNH48_08100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KNH48_08110	COG1302	Protein conserved in bacteria
KNH48_08115	COG0439	Biotin carboxylase
KNH48_08120	COG0511	ligase activity, forming carbon-carbon bonds
KNH48_08160	COG3854	ATPases associated with a variety of cellular activities
KNH48_08165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KNH48_08170	COG0006	proline dipeptidase activity
KNH48_08175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KNH48_08185	COG3872	metal-dependent enzyme
KNH48_08195	COG1752	Esterase of the alpha-beta hydrolase superfamily
KNH48_08205	COG0183	Belongs to the thiolase family
KNH48_08215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KNH48_08225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KNH48_08230	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KNH48_08240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KNH48_08245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KNH48_08260	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KNH48_08285	COG4537	Required for transformation and DNA binding
KNH48_08290	COG1459	type II secretion system
KNH48_08295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KNH48_08310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KNH48_08320	COG1940	carbohydrate kinase activity
KNH48_08325	COG4483	Protein conserved in bacteria
KNH48_08330	COG0705	Rhomboid family
KNH48_08330	COG0457	Tetratricopeptide repeat
KNH48_08340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KNH48_08350	COG0768	penicillin binding
KNH48_08355	COG0477	Major facilitator Superfamily
KNH48_08360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KNH48_08370	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KNH48_08375	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
KNH48_08380	COG0735	belongs to the Fur family
KNH48_08385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KNH48_08390	COG1121	(ABC) transporter
KNH48_08400	COG0791	NLP P60 protein
KNH48_08400	COG3883	PFAM NLP P60 protein
KNH48_08410	COG0513	Belongs to the DEAD box helicase family
KNH48_08430	COG2384	SAM-dependent methyltransferase
KNH48_08435	COG2010	Cytochrome c
KNH48_08450	COG0358	DNA primase activity
KNH48_08460	COG0517	IMP dehydrogenase activity
KNH48_08465	COG1381	Involved in DNA repair and RecF pathway recombination
KNH48_08475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KNH48_08480	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KNH48_08510	COG1610	YqeY-like protein
KNH48_08525	COG1283	sodium-dependent phosphate transmembrane transporter activity
KNH48_08530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KNH48_08535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KNH48_08540	COG2264	protein methyltransferase activity
KNH48_08550	COG0443	Heat shock 70 kDa protein
KNH48_08555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KNH48_08565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KNH48_08570	COG0481	GTPase activity
KNH48_08580	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
KNH48_08585	COG0268	Binds directly to 16S ribosomal RNA
KNH48_08590	COG1466	dna polymerase III delta subunit
KNH48_08600	COG2333	competence protein COMEC
KNH48_08600	COG0658	competence protein
KNH48_08605	COG2131	deaminase
KNH48_08615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KNH48_08625	COG0799	negative regulation of ribosome biogenesis
KNH48_08630	COG1713	HD superfamily hydrolase involved in NAD metabolism
KNH48_08635	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KNH48_08640	COG1534	Rna-binding protein
KNH48_08650	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KNH48_08655	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KNH48_08660	COG0247	lactate metabolic process
KNH48_08665	COG0277	FAD linked oxidase domain protein
KNH48_08675	COG2132	Multicopper oxidase
KNH48_08680	COG0071	Belongs to the small heat shock protein (HSP20) family
KNH48_08745	COG1183	phosphatidylcholine synthase activity
KNH48_08755	COG3634	alkyl hydroperoxide reductase activity
KNH48_08775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KNH48_08790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KNH48_08795	COG0572	uridine kinase
KNH48_08800	COG4122	O-methyltransferase activity
KNH48_08805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KNH48_08810	COG3906	Belongs to the UPF0473 family
KNH48_08815	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KNH48_08820	COG4472	Bacterial protein of unknown function (DUF965)
KNH48_08850	COG1522	sequence-specific DNA binding
KNH48_08860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KNH48_08865	COG1477	protein flavinylation
KNH48_08865	COG0457	Tetratricopeptide repeat
KNH48_08870	COG0482	sulfurtransferase activity
KNH48_08875	COG1104	cysteine desulfurase activity
KNH48_08880	COG1959	2 iron, 2 sulfur cluster binding
KNH48_08885	COG1028	Short-chain dehydrogenase reductase Sdr
KNH48_08890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KNH48_08895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KNH48_08900	COG0385	Bile acid
KNH48_08915	COG0124	histidyl-tRNA synthetase
KNH48_08925	COG4991	sh3 domain protein
KNH48_08925	COG3103	Sh3 type 3 domain protein
KNH48_08925	COG0860	N-Acetylmuramoyl-L-alanine amidase
KNH48_08940	COG1566	PFAM secretion protein HlyD family protein
KNH48_08945	COG1846	Transcriptional regulator
KNH48_08955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KNH48_08960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KNH48_08970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KNH48_08970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KNH48_08980	COG2244	polysaccharide biosynthetic process
KNH48_08985	COG2323	membrane
KNH48_08995	COG1862	Preprotein translocase
KNH48_09000	COG0343	queuine tRNA-ribosyltransferase activity
KNH48_09025	COG0217	transcriptional regulatory protein
KNH48_09035	COG1388	LysM domain
KNH48_09040	COG1827	regulation of RNA biosynthetic process
KNH48_09045	COG0077	Prephenate dehydratase
KNH48_09050	COG4492	Belongs to the UPF0735 family
KNH48_09055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KNH48_09060	COG3290	protein histidine kinase activity
KNH48_09065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KNH48_09070	COG2868	ribosomal protein
KNH48_09075	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KNH48_09080	COG1530	ribonuclease E activity
KNH48_09085	COG1994	Peptidase M50
KNH48_09095	COG2894	cell division
KNH48_09100	COG0850	regulation of cytokinetic process
KNH48_09110	COG1792	Involved in formation and maintenance of cell shape
KNH48_09115	COG1077	Cell shape determining protein MreB Mrl
KNH48_09120	COG2003	Belongs to the UPF0758 family
KNH48_09130	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KNH48_09155	COG1459	type II secretion system
KNH48_09165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KNH48_09205	COG0525	valine-tRNA ligase activity
KNH48_09215	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KNH48_09220	COG1388	LysM domain
KNH48_09220	COG1388	LysM domain
KNH48_09225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KNH48_09230	COG0113	porphobilinogen synthase activity
KNH48_09245	COG0181	hydroxymethylbilane synthase activity
KNH48_09250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KNH48_09265	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KNH48_09270	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KNH48_09275	COG1067	ATP-dependent peptidase activity
KNH48_09275	COG0470	DNA polymerase III
KNH48_09285	COG0544	peptidyl-prolyl cis-trans isomerase activity
KNH48_09290	COG0457	Tetratricopeptide repeat
KNH48_09290	COG1477	protein flavinylation
KNH48_09310	COG0622	Phosphoesterase
KNH48_09315	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KNH48_09320	COG1063	alcohol dehydrogenase
KNH48_09340	COG1846	Transcriptional regulator
KNH48_09360	COG2197	response regulator
KNH48_09365	COG0824	Thioesterase
KNH48_09370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KNH48_09375	COG1053	succinate dehydrogenase
KNH48_09380	COG2009	succinate dehydrogenase
KNH48_09385	COG1719	4-vinyl reductase, 4VR
KNH48_09395	COG0322	excinuclease ABC activity
KNH48_09400	COG3118	belongs to the thioredoxin family
KNH48_09405	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KNH48_09410	COG2086	electron transfer activity
KNH48_09415	COG1024	Enoyl-CoA hydratase
KNH48_09420	COG1309	transcriptional regulator
KNH48_09425	COG0318	PFAM AMP-dependent synthetase and ligase
KNH48_09435	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KNH48_09435	COG1796	DNA polymerase
KNH48_09440	COG1286	toxin biosynthetic process
KNH48_09445	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
KNH48_09460	COG0072	phenylalanine-tRNA ligase activity
KNH48_09460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KNH48_09465	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KNH48_09470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KNH48_09495	COG1695	Transcriptional regulator
KNH48_09515	COG0431	NADPH-dependent FMN reductase
KNH48_09520	COG1363	Peptidase, m42
KNH48_09535	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KNH48_09560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KNH48_09580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KNH48_09595	COG0237	dephospho-CoA kinase activity
KNH48_09600	COG1971	Probably functions as a manganese efflux pump
KNH48_09605	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KNH48_09610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KNH48_09610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KNH48_09615	COG0039	L-malate dehydrogenase activity
KNH48_09620	COG0538	isocitrate dehydrogenase activity
KNH48_09625	COG0372	Belongs to the citrate synthase family
KNH48_09630	COG2707	UPF0756 membrane protein
KNH48_09635	COG0628	permease
KNH48_09645	COG0205	6-phosphofructokinase activity
KNH48_09650	COG0825	malonyl-CoA metabolic process
KNH48_09655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KNH48_09660	COG0281	malic enzyme
KNH48_09665	COG0587	DNA-directed DNA polymerase activity
KNH48_09680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KNH48_09695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KNH48_09710	COG0589	response to stress
KNH48_09720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KNH48_09730	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KNH48_09735	COG3874	Sporulation protein YtfJ
KNH48_09745	COG1714	RDD family
KNH48_09750	COG0616	signal peptide processing
KNH48_09755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KNH48_09765	COG0301	tRNA thio-modification
KNH48_09775	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
KNH48_09780	COG1309	transcriptional regulator
KNH48_09785	COG1956	GAF domain-containing protein
KNH48_09790	COG2199	diguanylate cyclase activity
KNH48_09790	COG2203	Gaf domain
KNH48_09795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KNH48_09810	COG0506	proline dehydrogenase activity
KNH48_09830	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KNH48_09835	COG3383	formate dehydrogenase (NAD+) activity
KNH48_09840	COG2427	Protein of unknown function (DUF1641)
KNH48_09845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KNH48_09850	COG0315	cyclic pyranopterin monophosphate synthase activity
KNH48_09855	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KNH48_09860	COG0314	molybdopterin synthase activity
KNH48_09865	COG1763	Mo-molybdopterin cofactor biosynthetic process
KNH48_09870	COG0303	'Molybdopterin
KNH48_09885	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KNH48_09890	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KNH48_09895	COG4149	molybdate abc transporter
KNH48_09905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KNH48_09910	COG0454	-acetyltransferase
KNH48_09915	COG0517	IMP dehydrogenase activity
KNH48_09930	COG1605	Chorismate mutase
KNH48_09930	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KNH48_09945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KNH48_09950	COG1674	ftsk spoiiie
KNH48_09965	COG4848	Belongs to the UPF0354 family
KNH48_09970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KNH48_09975	COG2208	phosphoserine phosphatase activity
KNH48_09990	COG5584	Small secreted protein
KNH48_09995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KNH48_10000	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KNH48_10035	COG1349	DNA-binding transcription factor activity
KNH48_10040	COG2244	polysaccharide biosynthetic process
KNH48_10065	COG2814	Major facilitator Superfamily
KNH48_10080	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KNH48_10090	COG2267	carboxylic ester hydrolase activity
KNH48_10100	COG0367	asparagine synthase
KNH48_10105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KNH48_10130	COG0655	NAD(P)H dehydrogenase (quinone) activity
KNH48_10140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KNH48_10145	COG1116	anion transmembrane transporter activity
KNH48_10150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KNH48_10165	COG0783	Belongs to the Dps family
KNH48_10170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KNH48_10180	COG0803	Belongs to the bacterial solute-binding protein 9 family
KNH48_10190	COG4948	Mandelate Racemase Muconate Lactonizing
KNH48_10195	COG0318	PFAM AMP-dependent synthetase and ligase
KNH48_10200	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KNH48_10225	COG1575	Belongs to the MenA family. Type 1 subfamily
KNH48_10370	COG1285	pathogenesis
KNH48_10390	COG2608	mercury ion transmembrane transporter activity
KNH48_10400	COG1522	sequence-specific DNA binding
KNH48_10420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KNH48_10440	COG0726	polysaccharide deacetylase
KNH48_10455	COG0726	polysaccharide deacetylase
KNH48_10475	COG0038	chloride channel
KNH48_10485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KNH48_10490	COG1937	Protein conserved in bacteria
KNH48_10495	COG1525	nuclease
KNH48_10500	COG2190	(PTS) system
KNH48_10510	COG0840	transmembrane signaling receptor activity
KNH48_10525	COG1028	Short-chain dehydrogenase reductase Sdr
KNH48_10530	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KNH48_10545	COG1012	belongs to the aldehyde dehydrogenase family
KNH48_10570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KNH48_10580	COG2155	Conserved Protein
KNH48_10590	COG1098	S1 RNA binding domain
KNH48_10600	COG1902	pentaerythritol trinitrate reductase activity
KNH48_10605	COG0656	L-ascorbic acid biosynthetic process
KNH48_10625	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KNH48_10635	COG2814	Major facilitator Superfamily
KNH48_10640	COG2050	protein possibly involved in aromatic compounds catabolism
KNH48_10650	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KNH48_10660	COG0697	spore germination
KNH48_10675	COG3584	3D domain protein
KNH48_10685	COG1252	NADH dehydrogenase
KNH48_10690	COG0492	ferredoxin-NADP+ reductase activity
KNH48_10695	COG0316	Belongs to the HesB IscA family
KNH48_10700	COG4837	Protein of unknown function (DUF1462)
KNH48_10705	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KNH48_10715	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KNH48_10720	COG0647	UMP catabolic process
KNH48_10725	COG2445	Protein of unknown function DUF86
KNH48_10730	COG4470	Protein conserved in bacteria
KNH48_10735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KNH48_10740	COG0739	heme binding
KNH48_10750	COG3377	Domain of unknown function (DUF1805)
KNH48_10765	COG0822	iron-sulfur transferase activity
KNH48_10770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KNH48_10780	COG0396	ATPase activity
KNH48_10790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KNH48_10795	COG0509	glycine decarboxylation via glycine cleavage system
KNH48_10800	COG1393	Belongs to the ArsC family
KNH48_10805	COG1960	acyl-CoA dehydrogenase activity
KNH48_10810	COG0183	Belongs to the thiolase family
KNH48_10815	COG1250	3-hydroxyacyl-CoA dehydrogenase
KNH48_10815	COG1024	Enoyl-CoA hydratase
KNH48_10830	COG5577	PFAM Coat F domain
KNH48_10835	COG0772	Belongs to the SEDS family
KNH48_10840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KNH48_10855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KNH48_10865	COG0753	catalase activity
KNH48_10895	COG1595	DNA-templated transcription, initiation
KNH48_10900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KNH48_10915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KNH48_10950	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KNH48_10955	COG0557	exoribonuclease II activity
KNH48_10965	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KNH48_10970	COG0148	phosphopyruvate hydratase activity
KNH48_10975	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KNH48_10985	COG0126	phosphoglycerate kinase activity
KNH48_11010	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KNH48_11025	COG3383	formate dehydrogenase (NAD+) activity
KNH48_11040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KNH48_11055	COG4608	Belongs to the ABC transporter superfamily
KNH48_11060	COG0791	NLP P60 protein
KNH48_11065	COG4166	transmembrane transport
KNH48_11070	COG0444	Belongs to the ABC transporter superfamily
KNH48_11075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KNH48_11080	COG0601	transmembrane transport
KNH48_11085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KNH48_11090	COG0598	Magnesium transport protein CorA
KNH48_11100	COG2719	SpoVR family
KNH48_11105	COG3594	Acyltransferase
KNH48_11130	COG1392	Phosphate transport regulator
KNH48_11135	COG0306	phosphate transporter
KNH48_11150	COG2718	Belongs to the UPF0229 family
KNH48_11165	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KNH48_11180	COG2095	MarC family integral membrane protein
KNH48_11190	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KNH48_11195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KNH48_11200	COG0765	amino acid transport
KNH48_11205	COG1126	abc transporter atp-binding protein
KNH48_11210	COG2116	formate transmembrane transporter activity
KNH48_11220	COG1882	Formate acetyltransferase
KNH48_11225	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KNH48_11230	COG0431	NADPH-dependent FMN reductase
KNH48_11245	COG1131	(ABC) transporter
KNH48_11310	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KNH48_11315	COG2188	Transcriptional regulator
KNH48_11325	COG3104	oligopeptide transport
KNH48_11330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KNH48_11345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KNH48_11360	COG0640	Transcriptional regulator
KNH48_11365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KNH48_11370	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KNH48_11375	COG0640	Transcriptional regulator
KNH48_11385	COG5002	protein histidine kinase activity
KNH48_11385	COG3850	Histidine kinase
KNH48_11390	COG0745	RESPONSE REGULATOR receiver
KNH48_11400	COG2022	thiamine diphosphate biosynthetic process
KNH48_11410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KNH48_11415	COG0352	thiamine-phosphate diphosphorylase activity
KNH48_11425	COG2271	Major facilitator Superfamily
KNH48_11445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KNH48_11450	COG2323	membrane
KNH48_11555	COG3527	Alpha-acetolactate decarboxylase
KNH48_11560	COG0028	Belongs to the TPP enzyme family
KNH48_11565	COG0583	DNA-binding transcription factor activity
KNH48_11570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KNH48_11575	COG0735	belongs to the Fur family
KNH48_11590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KNH48_11600	COG4129	membrane
KNH48_11605	COG1737	Transcriptional regulator
KNH48_11610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KNH48_11610	COG1263	PTS System
KNH48_11615	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KNH48_11630	COG3557	Belongs to the UPF0374 family
KNH48_11645	COG1028	Short-chain dehydrogenase reductase Sdr
KNH48_11650	COG0583	DNA-binding transcription factor activity
KNH48_11655	COG0067	glutamate synthase
KNH48_11655	COG0070	glutamate synthase
KNH48_11655	COG0069	glutamate synthase activity
KNH48_11660	COG0493	'glutamate synthase
KNH48_11685	COG1988	membrane-bound metal-dependent
KNH48_11690	COG1194	a g-specific adenine glycosylase
KNH48_11720	COG0159	tryptophan synthase activity
KNH48_11745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KNH48_11745	COG0512	Glutamine amidotransferase of anthranilate synthase
KNH48_11755	COG0577	efflux transmembrane transporter activity
KNH48_11760	COG1136	(ABC) transporter
KNH48_11760	COG0577	efflux transmembrane transporter activity
KNH48_11765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KNH48_11780	COG1131	(ABC) transporter
KNH48_11820	COG0058	SHG alpha-glucan phosphorylase activity
KNH48_11825	COG0840	transmembrane signaling receptor activity
KNH48_11835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KNH48_11840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KNH48_11855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KNH48_11860	COG0066	3-isopropylmalate dehydratase activity
KNH48_11865	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KNH48_11875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KNH48_11880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KNH48_11885	COG0440	acetolactate synthase activity
KNH48_11890	COG0028	Belongs to the TPP enzyme family
KNH48_11900	COG1114	Component of the transport system for branched-chain amino acids
KNH48_11905	COG1366	Belongs to the anti-sigma-factor antagonist family
KNH48_11920	COG0670	Belongs to the BI1 family
KNH48_11925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KNH48_11945	COG3279	Response regulator of the LytR AlgR family
KNH48_11950	COG3275	phosphorelay sensor kinase activity
KNH48_11955	COG0252	asparaginase activity
KNH48_11960	COG2132	Multicopper oxidase
KNH48_11965	COG1309	transcriptional regulator
KNH48_12000	COG3739	integral membrane protein
KNH48_12005	COG3655	Transcriptional regulator
KNH48_12020	COG1823	symporter activity
KNH48_12025	COG2839	Protein conserved in bacteria
KNH48_12045	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
KNH48_12060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KNH48_12065	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KNH48_12085	COG0387	Pfam Sodium calcium exchanger
KNH48_12090	COG0477	Major facilitator Superfamily
KNH48_12095	COG1295	ribonuclease BN
KNH48_12100	COG4840	Belongs to the UPF0435 family
KNH48_12105	COG0024	Methionine aminopeptidase
KNH48_12115	COG0693	protein deglycase activity
KNH48_12120	COG1360	Flagellar Motor Protein
KNH48_12125	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KNH48_12140	COG3189	MarR family transcriptional regulator
KNH48_12150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KNH48_12155	COG1607	acyl-coa hydrolase
KNH48_12160	COG1077	Cell shape determining protein MreB Mrl
KNH48_12165	COG2268	Band 7 protein
KNH48_12170	COG1585	Membrane protein implicated in regulation of membrane protease activity
KNH48_12175	COG0626	cystathionine gamma-synthase activity
KNH48_12180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KNH48_12185	COG1854	S-ribosylhomocysteine lyase activity
KNH48_12190	COG2226	methyltransferase
KNH48_12195	COG0288	reversible hydration of carbon dioxide
KNH48_12215	COG2197	response regulator
KNH48_12235	COG4086	secreted protein
KNH48_12240	COG0737	Belongs to the 5'-nucleotidase family
KNH48_12255	COG3620	sequence-specific DNA binding
KNH48_12270	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KNH48_12275	COG1518	maintenance of DNA repeat elements
KNH48_12335	COG1304	FMN binding
KNH48_12340	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
KNH48_12345	COG0166	Belongs to the GPI family
KNH48_12355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KNH48_12355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KNH48_12355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KNH48_12360	COG1349	DNA-binding transcription factor activity
KNH48_12365	COG0371	Dehydrogenase
KNH48_12370	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
KNH48_12400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KNH48_12425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KNH48_12430	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
KNH48_12435	COG1461	Dihydroxyacetone kinase
KNH48_12440	COG2376	Dihydroxyacetone kinase
KNH48_12510	COG0778	Nitroreductase
KNH48_12515	COG1113	amino acid transport
KNH48_12525	COG2233	PERMEase
KNH48_12540	COG2233	PERMEase
KNH48_12550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KNH48_12575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KNH48_12580	COG3829	transcription factor binding
KNH48_12605	COG0833	amino acid
KNH48_12630	COG3588	fructose-bisphosphate aldolase
KNH48_12660	COG0494	nUDIX hydrolase
KNH48_12665	COG1715	Restriction endonuclease
KNH48_12710	COG2190	(PTS) system
KNH48_12725	COG3403	YqcI/YcgG family
KNH48_12770	COG1063	alcohol dehydrogenase
KNH48_12775	COG1929	Belongs to the glycerate kinase type-1 family
KNH48_12790	COG1879	ABC-type sugar transport system periplasmic component
KNH48_12795	COG1172	Belongs to the binding-protein-dependent transport system permease family
KNH48_12800	COG1129	ABC transporter
KNH48_12805	COG1869	D-ribose catabolic process
KNH48_12810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KNH48_12815	COG1609	Transcriptional regulator
KNH48_12835	COG1132	(ABC) transporter
KNH48_12850	COG1388	LysM domain
KNH48_12850	COG0791	NLP P60 protein
KNH48_12885	COG3153	acetyltransferase
KNH48_12885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KNH48_12890	COG5583	Uncharacterized small protein (DUF2292)
KNH48_12895	COG0431	NADPH-dependent FMN reductase
KNH48_12910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KNH48_12915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KNH48_12920	COG0516	GMP reductase activity
KNH48_12925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KNH48_12935	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KNH48_12960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KNH48_12970	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
KNH48_12975	COG2814	Major facilitator Superfamily
KNH48_12980	COG1764	response to oxidative stress
KNH48_12985	COG1126	abc transporter atp-binding protein
KNH48_12990	COG0765	amino acid transport
KNH48_12995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KNH48_13005	COG0326	Molecular chaperone. Has ATPase activity
KNH48_13035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KNH48_13045	COG1064	alcohol dehydrogenase
KNH48_13080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KNH48_13085	COG1597	lipid kinase activity
KNH48_13110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KNH48_13120	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KNH48_13140	COG4851	CamS sex pheromone cAM373 precursor
KNH48_13155	COG3344	reverse transcriptase
KNH48_13160	COG0210	DNA helicase
KNH48_13165	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
KNH48_13175	COG1470	cell adhesion involved in biofilm formation
KNH48_13200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KNH48_13205	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KNH48_13210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KNH48_13215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KNH48_13220	COG0047	phosphoribosylformylglycinamidine synthase activity
KNH48_13225	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KNH48_13235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KNH48_13240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KNH48_13245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KNH48_13265	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KNH48_13270	COG2190	(PTS) system
KNH48_13270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KNH48_13270	COG1263	PTS System
KNH48_13300	COG3711	transcriptional antiterminator
KNH48_13305	COG2252	PERMEase
KNH48_13330	COG2814	Major facilitator Superfamily
KNH48_13335	COG2197	response regulator
KNH48_13340	COG4585	Histidine kinase
KNH48_13345	COG1131	(ABC) transporter
KNH48_13355	COG0842	Transport permease protein
KNH48_13365	COG0471	metal ion transport
KNH48_13370	COG2356	endonuclease I
KNH48_13390	COG1131	(ABC) transporter
KNH48_13395	COG1725	Transcriptional regulator
KNH48_13400	COG1695	Transcriptional regulator
KNH48_13405	COG3479	Phenolic acid decarboxylase
KNH48_13410	COG2910	NAD(P)H-binding
KNH48_13415	COG1959	2 iron, 2 sulfur cluster binding
KNH48_13430	COG1994	Peptidase M50
KNH48_13435	COG1131	(ABC) transporter
KNH48_13455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KNH48_13460	COG0425	Belongs to the sulfur carrier protein TusA family
KNH48_13475	COG1279	arginine transmembrane transporter activity
KNH48_13500	COG0425	Belongs to the sulfur carrier protein TusA family
KNH48_13505	COG2391	methyltransferase activity
KNH48_13515	COG1028	Short-chain dehydrogenase reductase Sdr
KNH48_13530	COG1132	(ABC) transporter
KNH48_13540	COG1137	ATPase activity
KNH48_13575	COG1120	ATPase activity
KNH48_13595	COG3620	sequence-specific DNA binding
KNH48_13610	COG0714	Associated with various cellular activities
KNH48_13615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KNH48_13620	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KNH48_13625	COG1335	isochorismatase
KNH48_13630	COG4948	Mandelate Racemase Muconate Lactonizing
KNH48_13640	COG0463	Glycosyl transferase, family 2
KNH48_13645	COG2246	polysaccharide biosynthetic process
KNH48_13650	COG0459	protein refolding
KNH48_13655	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KNH48_13665	COG1266	CAAX protease self-immunity
KNH48_13675	COG0805	protein transport
KNH48_13680	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KNH48_13685	COG0488	(ABC) transporter
KNH48_13690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KNH48_13695	COG0456	acetyltransferase
KNH48_13700	COG1214	PFAM Peptidase M22, glycoprotease
KNH48_13705	COG0802	atpase or kinase
KNH48_13800	COG2183	response to ionizing radiation
KNH48_13805	COG2208	phosphoserine phosphatase activity
KNH48_13810	COG1191	sigma factor activity
KNH48_13815	COG2172	sigma factor antagonist activity
KNH48_13820	COG1366	Belongs to the anti-sigma-factor antagonist family
KNH48_13825	COG2208	phosphoserine phosphatase activity
KNH48_13830	COG2172	sigma factor antagonist activity
KNH48_13835	COG1366	Belongs to the anti-sigma-factor antagonist family
KNH48_13840	COG1366	Belongs to the anti-sigma-factor antagonist family
KNH48_13845	COG2337	Toxic component of a toxin-antitoxin (TA) module
KNH48_13850	COG0864	Transcriptional regulator
KNH48_13865	COG0736	holo-[acyl-carrier-protein] synthase activity
KNH48_13870	COG0705	Rhomboid family
KNH48_13875	COG0513	Belongs to the DEAD box helicase family
KNH48_13885	COG1280	lysine exporter protein (LysE YggA)
KNH48_13895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KNH48_13900	COG1609	Transcriptional regulator
KNH48_13905	COG0366	Alpha amylase catalytic
KNH48_13915	COG2182	Extracellular solute-binding protein
KNH48_13920	COG1175	transmembrane transport
KNH48_13925	COG3833	ABC-type maltose transport systems, permease component
KNH48_13930	COG5521	maltodextrose utilization protein MalA
KNH48_13935	COG1554	hydrolase, family 65, central catalytic
KNH48_13950	COG1181	Belongs to the D-alanine--D-alanine ligase family
KNH48_13960	COG1253	flavin adenine dinucleotide binding
KNH48_13965	COG0789	Transcriptional regulator
KNH48_13990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KNH48_14005	COG0629	single-stranded DNA binding
KNH48_14015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KNH48_14020	COG4786	Flagellar basal body rod
KNH48_14035	COG1609	Transcriptional regulator
KNH48_14040	COG0739	heme binding
KNH48_14045	COG2385	sporulation resulting in formation of a cellular spore
KNH48_14050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KNH48_14060	COG4836	Membrane
KNH48_14065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KNH48_14070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KNH48_14075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KNH48_14080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KNH48_14085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KNH48_14095	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KNH48_14100	COG0356	it plays a direct role in the translocation of protons across the membrane
KNH48_14110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KNH48_14115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KNH48_14120	COG4475	Protein of unknown function (DUF436)
KNH48_14125	COG0698	ribose 5-phosphate isomerase
KNH48_14130	COG0840	transmembrane signaling receptor activity
KNH48_14175	COG1971	Probably functions as a manganese efflux pump
KNH48_14180	COG0009	L-threonylcarbamoyladenylate synthase
KNH48_14195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KNH48_14205	COG1435	thymidine kinase activity
KNH48_14210	COG0254	rRNA binding
KNH48_14215	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KNH48_14220	COG1494	fructose-1,6-bisphosphatase
KNH48_14225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KNH48_14230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KNH48_14235	COG0191	fructose-bisphosphate aldolase activity
KNH48_14255	COG1131	(ABC) transporter
KNH48_14265	COG0504	CTP synthase activity
KNH48_14270	COG3343	RNA polymerase activity
KNH48_14290	COG1136	(ABC) transporter
KNH48_14325	COG1309	transcriptional regulator
KNH48_14330	COG1960	acyl-CoA dehydrogenase activity
KNH48_14335	COG1960	acyl-CoA dehydrogenase activity
KNH48_14340	COG0183	Belongs to the thiolase family
KNH48_14345	COG0247	lactate metabolic process
KNH48_14345	COG2181	nitrate reductase activity
KNH48_14350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KNH48_14365	COG0010	Belongs to the arginase family
KNH48_14370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KNH48_14380	COG1994	Peptidase M50
KNH48_14390	COG3465	dGTPase activity
KNH48_14405	COG0095	Lipoate-protein ligase
KNH48_14415	COG0280	phosphate acetyltransferase
KNH48_14420	COG3253	May function as heme-dependent peroxidase
KNH48_14430	COG2363	Small membrane protein
KNH48_14440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KNH48_14475	COG4555	ABC transporter
KNH48_14495	COG0351	phosphomethylpyrimidine kinase
KNH48_14515	COG0561	phosphatase activity
KNH48_14520	COG0514	ATP-dependent DNA helicase (RecQ)
KNH48_14525	COG1785	Belongs to the alkaline phosphatase family
KNH48_14530	COG1737	Transcriptional regulator
KNH48_14545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KNH48_14555	COG1346	cytolysis
KNH48_14560	COG1380	Effector of murein hydrolase LrgA
KNH48_14565	COG0583	DNA-binding transcription factor activity
KNH48_14680	COG2966	Psort location CytoplasmicMembrane, score
KNH48_14685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KNH48_14690	COG1966	Carbon starvation protein
KNH48_14695	COG1464	Belongs to the NlpA lipoprotein family
KNH48_14700	COG2011	ABC-type metal ion transport system permease component
KNH48_14705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KNH48_14710	COG1119	ATPase activity
KNH48_14725	COG0534	Mate efflux family protein
KNH48_14730	COG1442	glycosyl transferase family 8
KNH48_14735	COG2195	Cleaves the N-terminal amino acid of tripeptides
KNH48_14750	COG1404	Belongs to the peptidase S8 family
KNH48_14785	COG0028	Belongs to the TPP enzyme family
KNH48_14805	COG1132	(ABC) transporter
KNH48_14815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KNH48_14835	COG1366	Belongs to the anti-sigma-factor antagonist family
KNH48_14840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KNH48_14845	COG0765	amino acid transport
KNH48_14850	COG1126	abc transporter atp-binding protein
KNH48_14875	COG1126	abc transporter atp-binding protein
KNH48_14885	COG0765	amino acid transport
KNH48_14890	COG0579	oxidoreductase
KNH48_14895	COG0477	Major facilitator Superfamily
KNH48_14905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KNH48_14910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KNH48_14915	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KNH48_14920	COG4853	Protein conserved in bacteria
KNH48_14925	COG4863	YycH protein
KNH48_14930	COG5002	protein histidine kinase activity
KNH48_14935	COG0745	RESPONSE REGULATOR receiver
KNH48_14950	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KNH48_14955	COG0305	Participates in initiation and elongation during chromosome replication
KNH48_14960	COG0359	binds to the 23S rRNA
KNH48_14965	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KNH48_14975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KNH48_14985	COG0360	Binds together with S18 to 16S ribosomal RNA
KNH48_14990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KNH48_14995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KNH48_14995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KNH48_15000	COG0307	riboflavin synthase, alpha
KNH48_15005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KNH48_15005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KNH48_15010	COG0012	GTP binding
KNH48_15015	COG4481	Protein conserved in bacteria
KNH48_15020	COG0668	transmembrane transport
KNH48_15030	COG1811	Na channel or pump
KNH48_15035	COG1475	DNA binding
KNH48_15045	COG1475	DNA binding
KNH48_15050	COG0357	Ribosomal RNA small subunit methyltransferase G
KNH48_15055	COG0445	tRNA wobble uridine modification
KNH48_15060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KNH48_15065	COG1847	R3H domain protein
KNH48_15070	COG0706	membrane insertase activity
KNH48_15075	COG0594	ribonuclease P activity
KNH48_15080	COG0230	Belongs to the bacterial ribosomal protein bL34 family