locus-tag	class	description
ESP47_00005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ESP47_00010	COG2226	methyltransferase
ESP47_00030	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ESP47_00080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ESP47_00085	COG1113	amino acid transport
ESP47_00090	COG2814	Major facilitator Superfamily
ESP47_00100	COG1033	growth of symbiont in host cell
ESP47_00100	COG2409	Drug exporters of the RND superfamily
ESP47_00110	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
ESP47_00125	COG1960	acyl-CoA dehydrogenase activity
ESP47_00145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ESP47_00150	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ESP47_00160	COG1609	Transcriptional regulator
ESP47_00175	COG2996	Protein conserved in bacteria
ESP47_00180	COG0346	lactoylglutathione lyase activity
ESP47_00185	COG1482	cell wall glycoprotein biosynthetic process
ESP47_00195	COG0477	Major facilitator Superfamily
ESP47_00200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ESP47_00210	COG2188	Transcriptional regulator
ESP47_00215	COG0791	NLP P60 protein
ESP47_00215	COG1388	LysM domain
ESP47_00225	COG0768	penicillin binding
ESP47_00230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ESP47_00235	COG1739	Uncharacterized protein family UPF0029
ESP47_00245	COG2197	response regulator
ESP47_00250	COG0531	amino acid
ESP47_00255	COG1307	EDD domain protein, DegV family
ESP47_00260	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ESP47_00265	COG1040	competence protein
ESP47_00275	COG2747	anti-sigma28 factor FlgM
ESP47_00285	COG4786	Flagellar basal body rod
ESP47_00285	COG1256	bacterial-type flagellum assembly
ESP47_00290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ESP47_00300	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ESP47_00320	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ESP47_00325	COG1285	pathogenesis
ESP47_00330	COG0647	UMP catabolic process
ESP47_00340	COG2271	Major facilitator Superfamily
ESP47_00345	COG1113	amino acid transport
ESP47_00355	COG1113	amino acid transport
ESP47_00360	COG1067	ATP-dependent peptidase activity
ESP47_00375	COG2094	Belongs to the DNA glycosylase MPG family
ESP47_00385	COG1334	flagellar protein FlaG
ESP47_00390	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ESP47_00395	COG1516	flagellar protein fliS
ESP47_00420	COG0653	protein targeting
ESP47_00430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ESP47_00440	COG2884	Cell division ATP-binding protein ftsE
ESP47_00445	COG2177	Part of the ABC transporter FtsEX involved in
ESP47_00450	COG0739	heme binding
ESP47_00475	COG0460	homoserine dehydrogenase
ESP47_00485	COG3409	Peptidoglycan-binding domain 1 protein
ESP47_00485	COG0793	Belongs to the peptidase S41A family
ESP47_00500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ESP47_00505	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ESP47_00510	COG4605	iron ion homeostasis
ESP47_00515	COG4604	ABC transporter, ATP-binding protein
ESP47_00520	COG4607	ABC-type enterochelin transport system periplasmic component
ESP47_00535	COG0745	RESPONSE REGULATOR receiver
ESP47_00540	COG5002	protein histidine kinase activity
ESP47_00545	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ESP47_00555	COG0573	inorganic phosphate transmembrane transporter activity
ESP47_00560	COG0581	inorganic phosphate transmembrane transporter activity
ESP47_00570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ESP47_00575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ESP47_00625	COG0556	nucleotide-excision repair
ESP47_00630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ESP47_00635	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ESP47_00645	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ESP47_00650	COG1682	transport, permease protein
ESP47_00655	COG0463	Glycosyl transferase, family 2
ESP47_00655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ESP47_00660	COG3595	metallopeptidase activity
ESP47_00670	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ESP47_00675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ESP47_00680	COG0546	phosphoglycolate phosphatase activity
ESP47_00685	COG0110	maltose O-acetyltransferase activity
ESP47_00690	COG0457	Tetratricopeptide repeat
ESP47_00695	COG0492	ferredoxin-NADP+ reductase activity
ESP47_00700	COG1051	belongs to the nudix hydrolase family
ESP47_00705	COG1660	Displays ATPase and GTPase activities
ESP47_00710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ESP47_00715	COG1481	regulation of sporulation
ESP47_00720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_00755	COG3842	ATPase activity
ESP47_00760	COG2508	Transcriptional regulator
ESP47_00770	COG0189	ligase activity
ESP47_00775	COG0189	ligase activity
ESP47_00790	COG4399	Belongs to the UPF0754 family
ESP47_00800	COG0561	phosphatase activity
ESP47_00805	COG1024	Enoyl-CoA hydratase
ESP47_00815	COG0861	Integral membrane protein TerC family
ESP47_00820	COG0701	Predicted permease
ESP47_00825	COG3689	TIGRFAM TIGR03943 family protein
ESP47_00830	COG0420	3'-5' exonuclease activity
ESP47_00840	COG3481	metal-dependent phosphohydrolase, HD sub domain
ESP47_00850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ESP47_00865	COG1846	Transcriptional regulator
ESP47_00885	COG0537	adenosine 5'-monophosphoramidase activity
ESP47_00890	COG1131	(ABC) transporter
ESP47_00895	COG4473	ABC transporter
ESP47_00900	COG1473	amidohydrolase
ESP47_00905	COG3069	C4-dicarboxylate transmembrane transporter activity
ESP47_00910	COG2329	Antibiotic biosynthesis monooxygenase
ESP47_00915	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ESP47_00920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ESP47_00925	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ESP47_00930	COG1309	transcriptional regulator
ESP47_00935	COG1511	domain protein
ESP47_00940	COG1263	PTS System
ESP47_00940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_00940	COG1263	PTS System
ESP47_00940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_00940	COG2190	(PTS) system
ESP47_00940	COG2190	(PTS) system
ESP47_00945	COG1349	DNA-binding transcription factor activity
ESP47_00950	COG3254	rhamnose metabolic process
ESP47_00955	COG2814	Major facilitator Superfamily
ESP47_00960	COG0697	spore germination
ESP47_00965	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_00970	COG1999	signal sequence binding
ESP47_00985	COG0095	Lipoate-protein ligase
ESP47_00990	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_00995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ESP47_01005	COG0501	Belongs to the peptidase M48B family
ESP47_01025	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ESP47_01030	COG1074	ATP-dependent DNA helicase activity
ESP47_01065	COG2311	Membrane
ESP47_01070	COG0179	Fumarylacetoacetate (FAA) hydrolase
ESP47_01085	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_01090	COG1307	EDD domain protein, DegV family
ESP47_01100	COG0561	phosphatase activity
ESP47_01105	COG2151	metal-sulfur cluster biosynthetic enzyme
ESP47_01135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ESP47_01140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ESP47_01155	COG4608	Belongs to the ABC transporter superfamily
ESP47_01160	COG0601	transmembrane transport
ESP47_01170	COG0747	negative chemotaxis
ESP47_01185	COG0180	Tryptophanyl-tRNA synthetase
ESP47_01195	COG4166	transmembrane transport
ESP47_01200	COG0601	transmembrane transport
ESP47_01205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ESP47_01210	COG0444	Belongs to the ABC transporter superfamily
ESP47_01215	COG4608	Belongs to the ABC transporter superfamily
ESP47_01220	COG1393	Belongs to the ArsC family
ESP47_01225	COG4862	establishment of competence for transformation
ESP47_01230	COG4469	Competence protein
ESP47_01235	COG1164	Oligoendopeptidase f
ESP47_01250	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ESP47_01255	COG2346	COG2346, Truncated hemoglobins
ESP47_01275	COG0741	lytic transglycosylase activity
ESP47_01290	COG2357	RelA SpoT domain protein
ESP47_01300	COG0564	pseudouridine synthase activity
ESP47_01310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ESP47_01315	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ESP47_01350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ESP47_01385	COG2153	protein acetylation
ESP47_01395	COG2382	esterase
ESP47_01420	COG1940	carbohydrate kinase activity
ESP47_01430	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_01435	COG4152	abc transporter atp-binding protein
ESP47_01440	COG1668	transmembrane transport
ESP47_01450	COG3579	cysteine-type endopeptidase activity
ESP47_01505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ESP47_01510	COG3344	reverse transcriptase
ESP47_01515	COG2059	Chromate
ESP47_01520	COG2059	Chromate
ESP47_01525	COG1522	sequence-specific DNA binding
ESP47_01550	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ESP47_01555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ESP47_01575	COG1609	Transcriptional regulator
ESP47_01585	COG1554	hydrolase, family 65, central catalytic
ESP47_01590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESP47_01635	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_01650	COG1959	2 iron, 2 sulfur cluster binding
ESP47_01660	COG0730	response to heat
ESP47_01665	COG0783	Belongs to the Dps family
ESP47_01670	COG0673	inositol 2-dehydrogenase activity
ESP47_01675	COG3852	Histidine kinase
ESP47_01680	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ESP47_01695	COG0861	Integral membrane protein TerC family
ESP47_01720	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ESP47_01740	COG0542	response to heat
ESP47_01745	COG3949	Membrane
ESP47_01755	COG4873	Protein conserved in bacteria
ESP47_01770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_01785	COG2084	Dehydrogenase
ESP47_01790	COG0436	Aminotransferase
ESP47_01795	COG0784	Response regulator, receiver
ESP47_01795	COG0835	chemotaxis
ESP47_01805	COG2409	Drug exporters of the RND superfamily
ESP47_01805	COG1033	growth of symbiont in host cell
ESP47_01820	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_01830	COG4703	Protein of unknown function (DUF1797)
ESP47_01835	COG0517	IMP dehydrogenase activity
ESP47_01840	COG0583	DNA-binding transcription factor activity
ESP47_01845	COG2171	N-acyltransferase activity
ESP47_01850	COG1473	amidohydrolase
ESP47_01860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ESP47_01905	COG1982	Orn Lys Arg decarboxylase major
ESP47_01910	COG4476	Belongs to the UPF0223 family
ESP47_01925	COG0483	inositol monophosphate 1-phosphatase activity
ESP47_01935	COG1217	gtp-binding protein TYPA
ESP47_01945	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ESP47_01950	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ESP47_01955	COG4838	Belongs to the UPF0358 family
ESP47_01960	COG0772	Belongs to the SEDS family
ESP47_01965	COG1612	heme a metabolic process
ESP47_01970	COG0109	protoheme IX farnesyltransferase activity
ESP47_01975	COG2010	Cytochrome c
ESP47_01975	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ESP47_01990	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ESP47_01995	COG3336	cytochrome c oxidase
ESP47_02005	COG2340	Cysteine-rich secretory protein family
ESP47_02010	COG2050	protein possibly involved in aromatic compounds catabolism
ESP47_02030	COG3679	Belongs to the UPF0342 family
ESP47_02035	COG4471	UPF0298 protein
ESP47_02050	COG0742	ribosomal rna small subunit methyltransferase
ESP47_02055	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ESP47_02060	COG3314	Sporulation integral membrane protein YlbJ
ESP47_02065	COG1752	Esterase of the alpha-beta hydrolase superfamily
ESP47_02070	COG3480	Lon protease (S16) C-terminal proteolytic domain
ESP47_02075	COG1323	Belongs to the UPF0348 family
ESP47_02080	COG1399	metal-binding, possibly nucleic acid-binding protein
ESP47_02085	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ESP47_02095	COG0454	-acetyltransferase
ESP47_02100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ESP47_02105	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ESP47_02110	COG2001	Belongs to the MraZ family
ESP47_02115	COG0275	rRNA processing
ESP47_02120	COG4839	cell division protein FtsL
ESP47_02125	COG0768	penicillin binding
ESP47_02130	COG0768	penicillin binding
ESP47_02145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ESP47_02150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ESP47_02155	COG0772	Belongs to the SEDS family
ESP47_02160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ESP47_02165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ESP47_02170	COG0849	cell division
ESP47_02175	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ESP47_02190	COG1191	sigma factor activity
ESP47_02195	COG1191	sigma factor activity
ESP47_02200	COG1873	PFAM PRC-barrel domain
ESP47_02205	COG3584	3D domain protein
ESP47_02205	COG1388	LysM domain
ESP47_02215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ESP47_02220	COG1799	cell septum assembly
ESP47_02225	COG0762	integral membrane protein
ESP47_02230	COG2302	S4 RNA-binding domain
ESP47_02235	COG3599	regulation of cell shape
ESP47_02250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ESP47_02255	COG0564	pseudouridine synthase activity
ESP47_02270	COG0540	Belongs to the ATCase OTCase family
ESP47_02275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ESP47_02295	COG0167	dihydroorotate dehydrogenase activity
ESP47_02300	COG0284	orotidine-5'-phosphate decarboxylase activity
ESP47_02305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ESP47_02335	COG2207	Transcriptional regulator
ESP47_02335	COG1917	Cupin 2, conserved barrel domain protein
ESP47_02340	COG1070	Carbohydrate kinase
ESP47_02345	COG4806	L-rhamnose isomerase
ESP47_02350	COG0235	Class ii aldolase
ESP47_02355	COG1803	Methylglyoxal synthase
ESP47_02370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ESP47_02375	COG0477	Major facilitator Superfamily
ESP47_02380	COG0477	Major facilitator Superfamily
ESP47_02385	COG1309	transcriptional regulator
ESP47_02395	COG2076	Multidrug Resistance protein
ESP47_02410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESP47_02425	COG0628	permease
ESP47_02430	COG0561	phosphatase activity
ESP47_02435	COG3573	Dehydrogenase
ESP47_02440	COG3573	Dehydrogenase
ESP47_02470	COG0720	synthase
ESP47_02480	COG0385	Bile acid
ESP47_02490	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ESP47_02495	COG1561	YicC-like family, N-terminal region
ESP47_02500	COG2052	Domain of unknown function (DUF370)
ESP47_02505	COG0194	GDP metabolic process
ESP47_02510	COG1758	RNA polymerase activity
ESP47_02515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ESP47_02520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ESP47_02525	COG0242	peptide deformylase activity
ESP47_02530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ESP47_02535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ESP47_02535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ESP47_02540	COG0631	protein serine/threonine phosphatase activity
ESP47_02545	COG0515	serine threonine protein kinase
ESP47_02545	COG2815	serine threonine protein kinase
ESP47_02555	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ESP47_02560	COG1564	THIamine pyrophosphokinase
ESP47_02570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ESP47_02575	COG1302	Protein conserved in bacteria
ESP47_02580	COG1461	Dihydroxyacetone kinase
ESP47_02585	COG1760	l-serine dehydratase
ESP47_02590	COG1760	l-serine dehydratase
ESP47_02595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ESP47_02600	COG1349	DNA-binding transcription factor activity
ESP47_02605	COG0416	fatty acid biosynthetic process
ESP47_02610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ESP47_02615	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_02625	COG0571	ribonuclease III activity
ESP47_02630	COG1196	nuclear chromosome segregation
ESP47_02635	COG0552	protein localization to endoplasmic reticulum
ESP47_02640	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ESP47_02645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ESP47_02655	COG1837	Belongs to the UPF0109 family
ESP47_02665	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ESP47_02670	COG0336	Belongs to the RNA methyltransferase TrmD family
ESP47_02685	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ESP47_02700	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ESP47_02705	COG0045	succinate-CoA ligase (ADP-forming) activity
ESP47_02710	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ESP47_02715	COG0758	DNA mediated transformation
ESP47_02720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ESP47_02730	COG4974	Belongs to the 'phage' integrase family
ESP47_02735	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ESP47_02745	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ESP47_02750	COG1815	bacterial-type flagellum-dependent cell motility
ESP47_02755	COG1558	bacterial-type flagellum-dependent cell motility
ESP47_02760	COG1677	Flagellar hook-basal body complex protein FliE
ESP47_02765	COG1766	The M ring may be actively involved in energy transduction
ESP47_02770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ESP47_02780	COG1317	bacterial-type flagellum organization
ESP47_02785	COG1157	protein secretion by the type III secretion system
ESP47_02790	COG2882	bacterial-type flagellum organization
ESP47_02805	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ESP47_02815	COG4786	Flagellar basal body rod
ESP47_02825	COG1580	Controls the rotational direction of flagella during chemotaxis
ESP47_02830	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ESP47_02835	COG1776	CheC inhibitor of MCP methylation
ESP47_02835	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ESP47_02840	COG2201	protein-glutamate methylesterase activity
ESP47_02845	COG3190	flagellar
ESP47_02850	COG1338	Plays a role in the flagellum-specific transport system
ESP47_02855	COG1987	bacterial-type flagellum assembly
ESP47_02860	COG1684	flagellar biosynthetic protein fliR
ESP47_02865	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ESP47_02870	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ESP47_02875	COG1419	protein localization to endoplasmic reticulum
ESP47_02880	COG0455	bacterial-type flagellum organization
ESP47_02885	COG2201	protein-glutamate methylesterase activity
ESP47_02890	COG2198	Histidine kinase
ESP47_02890	COG0643	Histidine kinase
ESP47_02895	COG0835	chemotaxis
ESP47_02900	COG1776	CheC inhibitor of MCP methylation
ESP47_02905	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ESP47_02910	COG1191	sigma factor activity
ESP47_02920	COG0052	Belongs to the universal ribosomal protein uS2 family
ESP47_02925	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ESP47_02930	COG0528	UMP kinase activity
ESP47_02935	COG0233	cytoplasmic translational termination
ESP47_02945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ESP47_02950	COG4589	Belongs to the CDS family
ESP47_02960	COG0750	zinc metalloprotease
ESP47_02965	COG0442	prolyl-tRNA aminoacylation
ESP47_02970	COG2176	DNA-directed DNA polymerase activity
ESP47_02975	COG0779	Required for maturation of 30S ribosomal subunits
ESP47_02980	COG0195	Participates in both transcription termination and antitermination
ESP47_02985	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ESP47_02990	COG1358	cellular component organization or biogenesis
ESP47_03000	COG1550	Protein conserved in bacteria
ESP47_03005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ESP47_03010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ESP47_03015	COG0196	riboflavin kinase activity
ESP47_03020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ESP47_03025	COG1185	polyribonucleotide nucleotidyltransferase activity
ESP47_03030	COG0726	polysaccharide deacetylase
ESP47_03035	COG0612	Peptidase, M16
ESP47_03040	COG1873	PFAM PRC-barrel domain
ESP47_03045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ESP47_03050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ESP47_03055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ESP47_03065	COG0527	aspartate kinase activity
ESP47_03075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ESP47_03080	COG0740	serine-type endopeptidase activity
ESP47_03090	COG4980	gas vesicle protein
ESP47_03090	COG1674	ftsk spoiiie
ESP47_03095	COG1744	ABC transporter substrate-binding protein PnrA-like
ESP47_03100	COG3845	ABC transporter
ESP47_03105	COG4603	Belongs to the binding-protein-dependent transport system permease family
ESP47_03110	COG1079	Belongs to the binding-protein-dependent transport system permease family
ESP47_03115	COG0612	Peptidase, M16
ESP47_03120	COG0612	Peptidase, M16
ESP47_03125	COG0300	oxidoreductase activity
ESP47_03140	COG1426	Protein conserved in bacteria
ESP47_03145	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ESP47_03150	COG1546	Belongs to the CinA family
ESP47_03150	COG1058	Belongs to the CinA family
ESP47_03160	COG1418	mRNA catabolic process
ESP47_03165	COG1692	metallophosphoesterase
ESP47_03170	COG2359	stage V sporulation protein S
ESP47_03175	COG0826	peptidase U32
ESP47_03180	COG0826	peptidase U32
ESP47_03185	COG0531	amino acid
ESP47_03190	COG3829	transcription factor binding
ESP47_03195	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_03205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ESP47_03210	COG4550	Control of competence regulator ComK, YlbF/YmcA
ESP47_03220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ESP47_03225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ESP47_03250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ESP47_03265	COG0464	growth
ESP47_03275	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ESP47_03280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ESP47_03300	COG1321	iron dependent repressor
ESP47_03310	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ESP47_03320	COG1418	mRNA catabolic process
ESP47_03325	COG0488	(ABC) transporter
ESP47_03330	COG1413	lyase activity
ESP47_03345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ESP47_03350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ESP47_03355	COG1272	protein, Hemolysin III
ESP47_03360	COG2755	lipolytic protein G-D-S-L family
ESP47_03375	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ESP47_03380	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ESP47_03390	COG0840	transmembrane signaling receptor activity
ESP47_03395	COG4479	Belongs to the UPF0346 family
ESP47_03415	COG1876	peptidase activity
ESP47_03420	COG3409	Peptidoglycan-binding domain 1 protein
ESP47_03420	COG0793	Belongs to the peptidase S41A family
ESP47_03425	COG1846	Transcriptional regulator
ESP47_03430	COG2340	Cysteine-rich secretory protein family
ESP47_03435	COG0534	Mate efflux family protein
ESP47_03450	COG1793	dna ligase
ESP47_03450	COG3285	dna ligase
ESP47_03455	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ESP47_03460	COG0671	phosphoesterase, PA-phosphatase related
ESP47_03465	COG1368	sulfuric ester hydrolase activity
ESP47_03470	COG1331	Highly conserved protein containing a thioredoxin domain
ESP47_03475	COG2814	Major facilitator Superfamily
ESP47_03485	COG0745	RESPONSE REGULATOR receiver
ESP47_03490	COG5002	protein histidine kinase activity
ESP47_03500	COG0567	Dehydrogenase, E1 component
ESP47_03505	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESP47_03510	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_03540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ESP47_03550	COG1054	Belongs to the UPF0176 family
ESP47_03555	COG2135	peptidase activity
ESP47_03565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ESP47_03570	COG0516	GMP reductase activity
ESP47_03570	COG0517	IMP dehydrogenase activity
ESP47_03575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ESP47_03575	COG0723	plastoquinol--plastocyanin reductase activity
ESP47_03580	COG3584	3D domain protein
ESP47_03580	COG1388	LysM domain
ESP47_03585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ESP47_03590	COG1113	amino acid transport
ESP47_03595	COG1280	lysine exporter protein (LysE YggA)
ESP47_03600	COG0598	Magnesium transport protein CorA
ESP47_03615	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ESP47_03620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ESP47_03625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ESP47_03630	COG0131	Imidazoleglycerol-phosphate dehydratase
ESP47_03635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ESP47_03645	COG0107	imidazoleglycerol-phosphate synthase activity
ESP47_03650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ESP47_03650	COG0140	phosphoribosyl-ATP diphosphatase activity
ESP47_03660	COG2391	methyltransferase activity
ESP47_03665	COG2962	Rard protein
ESP47_03670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ESP47_03675	COG0569	domain protein
ESP47_03695	COG2807	transmembrane transport
ESP47_03700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ESP47_03710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ESP47_03720	COG1278	Cold shock
ESP47_03725	COG0302	gtp cyclohydrolase
ESP47_03730	COG3634	alkyl hydroperoxide reductase activity
ESP47_03745	COG0577	efflux transmembrane transporter activity
ESP47_03750	COG1136	(ABC) transporter
ESP47_03755	COG0642	Histidine kinase
ESP47_03760	COG0745	RESPONSE REGULATOR receiver
ESP47_03780	COG3328	transposase activity
ESP47_03790	COG0640	Transcriptional regulator
ESP47_03795	COG2814	Major facilitator Superfamily
ESP47_03800	COG5039	Polysaccharide pyruvyl transferase
ESP47_03805	COG1113	amino acid transport
ESP47_03820	COG0477	Major facilitator Superfamily
ESP47_03830	COG1132	(ABC) transporter
ESP47_03835	COG1132	(ABC) transporter
ESP47_03845	COG1380	Effector of murein hydrolase LrgA
ESP47_03850	COG1346	cytolysis
ESP47_03855	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_03880	COG2309	aminopeptidase activity
ESP47_03890	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ESP47_03910	COG0824	Thioesterase
ESP47_03920	COG4841	protein insertion into membrane
ESP47_03925	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ESP47_03935	COG1832	CoA-binding protein
ESP47_03940	COG0187	DNA topoisomerase II activity
ESP47_03945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ESP47_03965	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ESP47_03970	COG0574	Belongs to the PEP-utilizing enzyme family
ESP47_03970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ESP47_03990	COG2070	2-Nitropropane dioxygenase
ESP47_04000	COG0681	Belongs to the peptidase S26 family
ESP47_04015	COG2226	methyltransferase
ESP47_04040	COG0456	acetyltransferase
ESP47_04045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ESP47_04050	COG0456	acetyltransferase
ESP47_04055	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_04060	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ESP47_04065	COG0351	phosphomethylpyrimidine kinase
ESP47_04070	COG0352	thiamine-phosphate diphosphorylase activity
ESP47_04075	COG2258	MOSC domain
ESP47_04110	COG1309	transcriptional regulator
ESP47_04115	COG2814	Major facilitator Superfamily
ESP47_04120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESP47_04125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ESP47_04135	COG1809	phosphosulfolactate synthase activity
ESP47_04140	COG2045	Belongs to the ComB family
ESP47_04145	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ESP47_04150	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ESP47_04160	COG0789	Transcriptional regulator
ESP47_04165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ESP47_04170	COG0697	spore germination
ESP47_04175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ESP47_04180	COG0022	dehydrogenase e1 component
ESP47_04185	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESP47_04190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ESP47_04195	COG3284	Transcriptional regulator
ESP47_04200	COG3264	Mechanosensitive ion channel
ESP47_04200	COG1511	domain protein
ESP47_04215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ESP47_04220	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ESP47_04235	COG0183	Belongs to the thiolase family
ESP47_04240	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_04260	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ESP47_04265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ESP47_04270	COG2508	Transcriptional regulator
ESP47_04275	COG2233	PERMEase
ESP47_04285	COG2072	flavoprotein involved in K transport
ESP47_04295	COG0561	phosphatase activity
ESP47_04300	COG2322	membrane
ESP47_04315	COG0039	L-malate dehydrogenase activity
ESP47_04320	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_04325	COG2223	nitrite transmembrane transporter activity
ESP47_04330	COG3773	Cell wall hydrolase
ESP47_04335	COG0708	Exodeoxyribonuclease III
ESP47_04345	COG0297	glycogen (starch) synthase activity
ESP47_04350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ESP47_04355	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ESP47_04360	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ESP47_04380	COG1247	-acetyltransferase
ESP47_04385	COG0494	nUDIX hydrolase
ESP47_04390	COG1914	H( )-stimulated, divalent metal cation uptake system
ESP47_04395	COG0783	Belongs to the Dps family
ESP47_04405	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ESP47_04410	COG1131	(ABC) transporter
ESP47_04435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ESP47_04445	COG2030	dehydratase
ESP47_04450	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_04465	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
ESP47_04470	COG0709	Synthesizes selenophosphate from selenide and ATP
ESP47_04480	COG0701	Predicted permease
ESP47_04485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ESP47_04490	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ESP47_04500	COG1252	NADH dehydrogenase
ESP47_04505	COG2404	hydrolase activity, acting on ester bonds
ESP47_04515	COG4990	cell redox homeostasis
ESP47_04520	COG0789	Transcriptional regulator
ESP47_04545	COG0436	Aminotransferase
ESP47_04550	COG0165	Argininosuccinate lyase
ESP47_04555	COG0137	argininosuccinate synthase activity
ESP47_04560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ESP47_04565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ESP47_04570	COG0505	Belongs to the CarA family
ESP47_04575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ESP47_04580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ESP47_04585	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ESP47_04590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ESP47_04605	COG3546	catalase activity
ESP47_04625	COG1619	proteins homologs of microcin C7 resistance protein MccF
ESP47_04630	COG2027	D-alanyl-D-alanine carboxypeptidase
ESP47_04635	COG0204	Acyl-transferase
ESP47_04645	COG4846	Membrane protein involved in cytochrome C biogenesis
ESP47_04650	COG2201	protein-glutamate methylesterase activity
ESP47_04655	COG0785	Cytochrome C biogenesis protein
ESP47_04660	COG3763	UPF0154 protein
ESP47_04675	COG4224	UPF0291 protein
ESP47_04680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ESP47_04690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ESP47_04700	COG0791	NLP P60 protein
ESP47_04700	COG1388	LysM domain
ESP47_04745	COG5280	Phage tail tape measure protein TP901
ESP47_04745	COG3953	SLT domain
ESP47_04785	COG0740	serine-type endopeptidase activity
ESP47_04820	COG0582	viral genome integration into host DNA
ESP47_04825	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ESP47_04865	COG0629	single-stranded DNA binding
ESP47_04905	COG1396	sequence-specific DNA binding
ESP47_04915	COG2176	DNA-directed DNA polymerase activity
ESP47_04920	COG0556	nucleotide-excision repair
ESP47_04935	COG0582	viral genome integration into host DNA
ESP47_04940	COG0174	glutamine synthetase
ESP47_04945	COG0789	Transcriptional regulator
ESP47_04950	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ESP47_04965	COG2233	PERMEase
ESP47_04975	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ESP47_04980	COG0116	Belongs to the methyltransferase superfamily
ESP47_04995	COG4474	Belongs to the UPF0398 family
ESP47_05005	COG3359	exonuclease
ESP47_05010	COG1205	dead DEAH box helicase
ESP47_05010	COG1111	helicase
ESP47_05015	COG0071	Belongs to the small heat shock protein (HSP20) family
ESP47_05040	COG3331	DNA recombination
ESP47_05045	COG4499	WXG100 protein secretion system (Wss), protein YukC
ESP47_05045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ESP47_05050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ESP47_05055	COG3935	DnaD domain protein
ESP47_05065	COG3344	reverse transcriptase
ESP47_05070	COG0017	Asparaginyl-tRNA synthetase
ESP47_05085	COG1199	ATP-dependent helicase activity
ESP47_05085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ESP47_05090	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ESP47_05095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ESP47_05115	COG0438	transferase activity, transferring glycosyl groups
ESP47_05120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ESP47_05125	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ESP47_05130	COG1694	Mazg nucleotide pyrophosphohydrolase
ESP47_05135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ESP47_05145	COG2738	Putative neutral zinc metallopeptidase
ESP47_05155	COG4347	Protein of unknown function (DUF1405)
ESP47_05165	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ESP47_05180	COG5582	Belongs to the UPF0302 family
ESP47_05185	COG0457	Tetratricopeptide repeat
ESP47_05195	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ESP47_05200	COG0287	Prephenate dehydrogenase
ESP47_05205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ESP47_05210	COG4401	Chorismate mutase type I
ESP47_05215	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ESP47_05220	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ESP47_05225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ESP47_05230	COG0105	UTP biosynthetic process
ESP47_05235	COG0142	geranyltranstransferase activity
ESP47_05240	COG2226	methyltransferase
ESP47_05245	COG0142	geranyltranstransferase activity
ESP47_05255	COG0776	regulation of translation
ESP47_05260	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ESP47_05280	COG1160	GTP binding
ESP47_05295	COG0539	negative regulation of cytoplasmic translation
ESP47_05300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ESP47_05305	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ESP47_05310	COG2959	enzyme of heme biosynthesis
ESP47_05315	COG3773	Cell wall hydrolase
ESP47_05315	COG3409	Peptidoglycan-binding domain 1 protein
ESP47_05320	COG2339	peptidase activity
ESP47_05325	COG0492	ferredoxin-NADP+ reductase activity
ESP47_05330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ESP47_05340	COG1408	metallophosphoesterase
ESP47_05355	COG3546	catalase activity
ESP47_05370	COG1266	CAAX protease self-immunity
ESP47_05375	COG0514	ATP-dependent DNA helicase (RecQ)
ESP47_05385	COG1141	Ferredoxin
ESP47_05390	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ESP47_05395	COG0741	lytic transglycosylase activity
ESP47_05395	COG1196	nuclear chromosome segregation
ESP47_05395	COG0739	heme binding
ESP47_05400	COG5002	protein histidine kinase activity
ESP47_05405	COG0745	RESPONSE REGULATOR receiver
ESP47_05410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ESP47_05415	COG1333	cytochrome c biogenesis protein
ESP47_05420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ESP47_05425	COG1187	pseudouridine synthase activity
ESP47_05430	COG0700	Nucleoside recognition
ESP47_05435	COG2715	membrane protein required for spore maturation
ESP47_05440	COG1686	Belongs to the peptidase S11 family
ESP47_05445	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ESP47_05470	COG0697	spore germination
ESP47_05490	COG1191	sigma factor activity
ESP47_05505	COG1686	Belongs to the peptidase S11 family
ESP47_05510	COG4974	Belongs to the 'phage' integrase family
ESP47_05520	COG0735	belongs to the Fur family
ESP47_05525	COG1300	Membrane
ESP47_05530	COG1379	DNA repair
ESP47_05545	COG0667	Aldo Keto reductase
ESP47_05555	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ESP47_05560	COG3853	Toxic anion resistance protein (TelA)
ESP47_05565	COG1073	alpha beta
ESP47_05570	COG3858	chitin binding
ESP47_05570	COG1388	LysM domain
ESP47_05580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ESP47_05585	COG0300	oxidoreductase activity
ESP47_05590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ESP47_05600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ESP47_05605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ESP47_05615	COG2195	Cleaves the N-terminal amino acid of tripeptides
ESP47_05635	COG1376	ErfK ybiS ycfS ynhG family protein
ESP47_05645	COG1105	Belongs to the carbohydrate kinase PfkB family
ESP47_05655	COG0508	dehydrogenase complex catalyzes the overall conversion of
ESP47_05660	COG0022	dehydrogenase e1 component
ESP47_05665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ESP47_05670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ESP47_05690	COG0584	glycerophosphoryl diester phosphodiesterase
ESP47_05695	COG0745	RESPONSE REGULATOR receiver
ESP47_05705	COG0750	zinc metalloprotease
ESP47_05710	COG0497	DNA recombination
ESP47_05720	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ESP47_05725	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ESP47_05740	COG1570	exodeoxyribonuclease VII activity
ESP47_05755	COG1302	Protein conserved in bacteria
ESP47_05760	COG0439	Biotin carboxylase
ESP47_05765	COG0511	ligase activity, forming carbon-carbon bonds
ESP47_05805	COG3854	ATPases associated with a variety of cellular activities
ESP47_05810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ESP47_05815	COG0006	proline dipeptidase activity
ESP47_05820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ESP47_05830	COG3872	metal-dependent enzyme
ESP47_05840	COG1752	Esterase of the alpha-beta hydrolase superfamily
ESP47_05850	COG3327	negative regulation of DNA-templated transcription, initiation
ESP47_05855	COG0183	Belongs to the thiolase family
ESP47_05860	COG1250	3-hydroxyacyl-CoA dehydrogenase
ESP47_05865	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_05870	COG1024	Enoyl-CoA hydratase
ESP47_05875	COG0492	ferredoxin-NADP+ reductase activity
ESP47_05880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ESP47_05885	COG0095	Lipoate-protein ligase
ESP47_05890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ESP47_05895	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ESP47_05905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ESP47_05910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ESP47_05925	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ESP47_05950	COG4537	Required for transformation and DNA binding
ESP47_05955	COG1459	type II secretion system
ESP47_05960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ESP47_05975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ESP47_05985	COG1940	carbohydrate kinase activity
ESP47_05990	COG4483	Protein conserved in bacteria
ESP47_05995	COG0705	Rhomboid family
ESP47_05995	COG0457	Tetratricopeptide repeat
ESP47_06000	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ESP47_06010	COG0768	penicillin binding
ESP47_06015	COG0477	Major facilitator Superfamily
ESP47_06020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ESP47_06035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ESP47_06040	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ESP47_06045	COG0735	belongs to the Fur family
ESP47_06050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ESP47_06055	COG1121	(ABC) transporter
ESP47_06065	COG3883	PFAM NLP P60 protein
ESP47_06065	COG0791	NLP P60 protein
ESP47_06070	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ESP47_06075	COG0513	Belongs to the DEAD box helicase family
ESP47_06085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ESP47_06090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ESP47_06095	COG2384	SAM-dependent methyltransferase
ESP47_06100	COG2010	Cytochrome c
ESP47_06110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ESP47_06115	COG0358	DNA primase activity
ESP47_06125	COG0517	IMP dehydrogenase activity
ESP47_06135	COG1381	Involved in DNA repair and RecF pathway recombination
ESP47_06150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ESP47_06155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ESP47_06160	COG1480	7TM receptor with intracellular HD hydrolase
ESP47_06165	COG1702	phosphate starvation-inducible protein PhoH
ESP47_06180	COG1610	YqeY-like protein
ESP47_06195	COG1283	sodium-dependent phosphate transmembrane transporter activity
ESP47_06200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ESP47_06205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ESP47_06210	COG2264	protein methyltransferase activity
ESP47_06220	COG0443	Heat shock 70 kDa protein
ESP47_06225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ESP47_06235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ESP47_06240	COG0481	GTPase activity
ESP47_06245	COG0860	N-Acetylmuramoyl-L-alanine amidase
ESP47_06250	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ESP47_06255	COG0268	Binds directly to 16S ribosomal RNA
ESP47_06260	COG1466	dna polymerase III delta subunit
ESP47_06270	COG0658	competence protein
ESP47_06270	COG2333	competence protein COMEC
ESP47_06275	COG2131	deaminase
ESP47_06280	COG1555	photosystem II stabilization
ESP47_06280	COG1596	polysaccharide export
ESP47_06285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ESP47_06290	COG2226	methyltransferase
ESP47_06295	COG0799	negative regulation of ribosome biogenesis
ESP47_06300	COG1713	HD superfamily hydrolase involved in NAD metabolism
ESP47_06305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ESP47_06310	COG1534	Rna-binding protein
ESP47_06320	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ESP47_06325	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ESP47_06330	COG0247	lactate metabolic process
ESP47_06335	COG0277	FAD linked oxidase domain protein
ESP47_06340	COG3835	regulator
ESP47_06345	COG2132	Multicopper oxidase
ESP47_06350	COG0071	Belongs to the small heat shock protein (HSP20) family
ESP47_06360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ESP47_06400	COG1183	phosphatidylcholine synthase activity
ESP47_06415	COG3634	alkyl hydroperoxide reductase activity
ESP47_06420	COG0450	alkyl hydroperoxide reductase
ESP47_06455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ESP47_06460	COG0572	uridine kinase
ESP47_06465	COG4122	O-methyltransferase activity
ESP47_06470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ESP47_06475	COG3906	Belongs to the UPF0473 family
ESP47_06480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ESP47_06485	COG4472	Bacterial protein of unknown function (DUF965)
ESP47_06490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ESP47_06495	COG0628	permease
ESP47_06525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ESP47_06535	COG0482	sulfurtransferase activity
ESP47_06540	COG1104	cysteine desulfurase activity
ESP47_06545	COG1959	2 iron, 2 sulfur cluster binding
ESP47_06565	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_06570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ESP47_06575	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ESP47_06580	COG0385	Bile acid
ESP47_06590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ESP47_06595	COG0124	histidyl-tRNA synthetase
ESP47_06600	COG4991	sh3 domain protein
ESP47_06600	COG0860	N-Acetylmuramoyl-L-alanine amidase
ESP47_06600	COG3103	Sh3 type 3 domain protein
ESP47_06605	COG2814	Major facilitator Superfamily
ESP47_06610	COG1566	PFAM secretion protein HlyD family protein
ESP47_06615	COG1846	Transcriptional regulator
ESP47_06620	COG1490	D-aminoacyl-tRNA deacylase activity
ESP47_06625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ESP47_06630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ESP47_06635	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ESP47_06635	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ESP47_06650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ESP47_06650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ESP47_06660	COG2244	polysaccharide biosynthetic process
ESP47_06665	COG2323	membrane
ESP47_06675	COG1862	Preprotein translocase
ESP47_06680	COG0343	queuine tRNA-ribosyltransferase activity
ESP47_06685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ESP47_06700	COG0632	four-way junction helicase activity
ESP47_06705	COG0217	transcriptional regulatory protein
ESP47_06715	COG1388	LysM domain
ESP47_06720	COG1827	regulation of RNA biosynthetic process
ESP47_06725	COG0077	Prephenate dehydratase
ESP47_06730	COG4492	Belongs to the UPF0735 family
ESP47_06735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ESP47_06740	COG3290	protein histidine kinase activity
ESP47_06745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ESP47_06750	COG2868	ribosomal protein
ESP47_06755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ESP47_06760	COG1530	ribonuclease E activity
ESP47_06765	COG1994	Peptidase M50
ESP47_06775	COG2894	cell division
ESP47_06780	COG0850	regulation of cytokinetic process
ESP47_06790	COG1792	Involved in formation and maintenance of cell shape
ESP47_06795	COG1077	Cell shape determining protein MreB Mrl
ESP47_06800	COG2003	Belongs to the UPF0758 family
ESP47_06810	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ESP47_06835	COG1459	type II secretion system
ESP47_06845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ESP47_06880	COG0285	dihydrofolate synthase activity
ESP47_06895	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ESP47_06900	COG1388	LysM domain
ESP47_06900	COG1388	LysM domain
ESP47_06905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ESP47_06910	COG0113	porphobilinogen synthase activity
ESP47_06920	COG0181	hydroxymethylbilane synthase activity
ESP47_06925	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ESP47_06940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ESP47_06945	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ESP47_06950	COG0470	DNA polymerase III
ESP47_06950	COG1067	ATP-dependent peptidase activity
ESP47_06960	COG0544	peptidyl-prolyl cis-trans isomerase activity
ESP47_06965	COG0457	Tetratricopeptide repeat
ESP47_06965	COG1477	protein flavinylation
ESP47_06995	COG0622	Phosphoesterase
ESP47_07000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ESP47_07005	COG5401	PFAM Sporulation and spore germination
ESP47_07015	COG5577	PFAM Coat F domain
ESP47_07020	COG1063	alcohol dehydrogenase
ESP47_07025	COG5577	PFAM Coat F domain
ESP47_07040	COG1846	Transcriptional regulator
ESP47_07070	COG2197	response regulator
ESP47_07075	COG0824	Thioesterase
ESP47_07080	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ESP47_07085	COG1053	succinate dehydrogenase
ESP47_07090	COG2009	succinate dehydrogenase
ESP47_07095	COG1719	4-vinyl reductase, 4VR
ESP47_07105	COG0322	excinuclease ABC activity
ESP47_07110	COG3118	belongs to the thioredoxin family
ESP47_07125	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ESP47_07130	COG2086	electron transfer activity
ESP47_07135	COG1024	Enoyl-CoA hydratase
ESP47_07140	COG1309	transcriptional regulator
ESP47_07145	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_07150	COG1193	negative regulation of DNA recombination
ESP47_07155	COG1796	DNA polymerase
ESP47_07155	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ESP47_07160	COG1286	toxin biosynthetic process
ESP47_07165	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ESP47_07175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ESP47_07175	COG0072	phenylalanine-tRNA ligase activity
ESP47_07180	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ESP47_07185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ESP47_07220	COG2329	Antibiotic biosynthesis monooxygenase
ESP47_07235	COG1695	Transcriptional regulator
ESP47_07255	COG0431	NADPH-dependent FMN reductase
ESP47_07285	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ESP47_07295	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ESP47_07305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ESP47_07315	COG1484	DNA-dependent DNA replication
ESP47_07320	COG3611	Membrane attachment protein
ESP47_07325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ESP47_07330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ESP47_07335	COG0237	dephospho-CoA kinase activity
ESP47_07340	COG1971	Probably functions as a manganese efflux pump
ESP47_07345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ESP47_07350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ESP47_07350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ESP47_07355	COG0039	L-malate dehydrogenase activity
ESP47_07360	COG0538	isocitrate dehydrogenase activity
ESP47_07365	COG0372	Belongs to the citrate synthase family
ESP47_07370	COG2707	UPF0756 membrane protein
ESP47_07375	COG0628	permease
ESP47_07385	COG0205	6-phosphofructokinase activity
ESP47_07390	COG0825	malonyl-CoA metabolic process
ESP47_07395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ESP47_07400	COG0281	malic enzyme
ESP47_07405	COG0587	DNA-directed DNA polymerase activity
ESP47_07420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ESP47_07430	COG4109	DRTGG domain
ESP47_07435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ESP47_07440	COG0006	proline dipeptidase activity
ESP47_07450	COG0589	response to stress
ESP47_07460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ESP47_07465	COG0827	DNA restriction-modification system
ESP47_07470	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ESP47_07475	COG3874	Sporulation protein YtfJ
ESP47_07485	COG1714	RDD family
ESP47_07490	COG0616	signal peptide processing
ESP47_07495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ESP47_07505	COG0301	tRNA thio-modification
ESP47_07510	COG1104	cysteine desulfurase activity
ESP47_07515	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ESP47_07520	COG1309	transcriptional regulator
ESP47_07525	COG1956	GAF domain-containing protein
ESP47_07530	COG2199	diguanylate cyclase activity
ESP47_07530	COG2203	Gaf domain
ESP47_07540	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ESP47_07550	COG0506	proline dehydrogenase activity
ESP47_07555	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_07560	COG3829	transcription factor binding
ESP47_07560	COG3290	protein histidine kinase activity
ESP47_07575	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ESP47_07580	COG3383	formate dehydrogenase (NAD+) activity
ESP47_07585	COG2427	Protein of unknown function (DUF1641)
ESP47_07590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ESP47_07595	COG0315	cyclic pyranopterin monophosphate synthase activity
ESP47_07600	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ESP47_07605	COG0314	molybdopterin synthase activity
ESP47_07610	COG1763	Mo-molybdopterin cofactor biosynthetic process
ESP47_07615	COG0303	'Molybdopterin
ESP47_07630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ESP47_07635	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ESP47_07640	COG4149	molybdate abc transporter
ESP47_07650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ESP47_07655	COG0454	-acetyltransferase
ESP47_07660	COG0517	IMP dehydrogenase activity
ESP47_07665	COG0123	including yeast histone deacetylase and acetoin utilization protein
ESP47_07675	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ESP47_07675	COG1605	Chorismate mutase
ESP47_07680	COG4980	gas vesicle protein
ESP47_07690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ESP47_07695	COG1674	ftsk spoiiie
ESP47_07705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ESP47_07710	COG4848	Belongs to the UPF0354 family
ESP47_07715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ESP47_07720	COG2208	phosphoserine phosphatase activity
ESP47_07725	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ESP47_07730	COG5002	protein histidine kinase activity
ESP47_07730	COG0784	Response regulator, receiver
ESP47_07745	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ESP47_07750	COG1363	Peptidase, m42
ESP47_07755	COG5584	Small secreted protein
ESP47_07765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ESP47_07770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ESP47_07780	COG0510	thiamine kinase activity
ESP47_07805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ESP47_07810	COG1349	DNA-binding transcription factor activity
ESP47_07815	COG2244	polysaccharide biosynthetic process
ESP47_07835	COG0495	leucyl-tRNA aminoacylation
ESP47_07840	COG2814	Major facilitator Superfamily
ESP47_07855	COG0275	rRNA processing
ESP47_07870	COG2267	carboxylic ester hydrolase activity
ESP47_07875	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ESP47_07880	COG0367	asparagine synthase
ESP47_07885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ESP47_07890	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ESP47_07900	COG1506	peptidase
ESP47_07905	COG0655	NAD(P)H dehydrogenase (quinone) activity
ESP47_07915	COG1070	Carbohydrate kinase
ESP47_07920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ESP47_07925	COG1116	anion transmembrane transporter activity
ESP47_07930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESP47_07945	COG0783	Belongs to the Dps family
ESP47_07950	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ESP47_07960	COG0803	Belongs to the bacterial solute-binding protein 9 family
ESP47_07970	COG4948	Mandelate Racemase Muconate Lactonizing
ESP47_07975	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_07980	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ESP47_07985	COG0596	Alpha beta hydrolase
ESP47_07990	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ESP47_07995	COG1169	isochorismate synthase
ESP47_08000	COG1575	Belongs to the MenA family. Type 1 subfamily
ESP47_08125	COG1285	pathogenesis
ESP47_08165	COG2217	Heavy metal translocating P-type atpase
ESP47_08170	COG2608	mercury ion transmembrane transporter activity
ESP47_08185	COG1522	sequence-specific DNA binding
ESP47_08205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ESP47_08225	COG0726	polysaccharide deacetylase
ESP47_08255	COG0038	chloride channel
ESP47_08265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ESP47_08270	COG1937	Protein conserved in bacteria
ESP47_08275	COG1525	nuclease
ESP47_08280	COG2190	(PTS) system
ESP47_08295	COG0235	Class ii aldolase
ESP47_08300	COG2160	L-arabinose isomerase activity
ESP47_08305	COG1609	Transcriptional regulator
ESP47_08310	COG4213	ABC transporter substrate-binding protein
ESP47_08320	COG4214	carbohydrate transport
ESP47_08325	COG2160	L-arabinose isomerase activity
ESP47_08335	COG1609	Transcriptional regulator
ESP47_08340	COG0840	transmembrane signaling receptor activity
ESP47_08355	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_08360	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ESP47_08380	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_08400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ESP47_08410	COG2155	Conserved Protein
ESP47_08425	COG1098	S1 RNA binding domain
ESP47_08440	COG0656	L-ascorbic acid biosynthetic process
ESP47_08460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ESP47_08490	COG2814	Major facilitator Superfamily
ESP47_08495	COG2050	protein possibly involved in aromatic compounds catabolism
ESP47_08515	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ESP47_08525	COG0697	spore germination
ESP47_08535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ESP47_08540	COG3584	3D domain protein
ESP47_08550	COG1252	NADH dehydrogenase
ESP47_08555	COG0492	ferredoxin-NADP+ reductase activity
ESP47_08580	COG0316	Belongs to the HesB IscA family
ESP47_08585	COG4837	Protein of unknown function (DUF1462)
ESP47_08590	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ESP47_08595	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ESP47_08600	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ESP47_08605	COG0647	UMP catabolic process
ESP47_08610	COG2445	Protein of unknown function DUF86
ESP47_08615	COG4470	Protein conserved in bacteria
ESP47_08620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ESP47_08625	COG0739	heme binding
ESP47_08635	COG3377	Domain of unknown function (DUF1805)
ESP47_08640	COG0737	Belongs to the 5'-nucleotidase family
ESP47_08645	COG0719	Fe-S assembly protein
ESP47_08650	COG0822	iron-sulfur transferase activity
ESP47_08655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ESP47_08660	COG0719	Fe-S assembly protein
ESP47_08665	COG0396	ATPase activity
ESP47_08680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ESP47_08685	COG0509	glycine decarboxylation via glycine cleavage system
ESP47_08690	COG1393	Belongs to the ArsC family
ESP47_08695	COG1960	acyl-CoA dehydrogenase activity
ESP47_08700	COG0183	Belongs to the thiolase family
ESP47_08705	COG1024	Enoyl-CoA hydratase
ESP47_08705	COG1250	3-hydroxyacyl-CoA dehydrogenase
ESP47_08720	COG5577	PFAM Coat F domain
ESP47_08725	COG0772	Belongs to the SEDS family
ESP47_08730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ESP47_08745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ESP47_08750	COG2202	Pas domain
ESP47_08750	COG2200	EAL domain
ESP47_08750	COG2199	diguanylate cyclase activity
ESP47_08755	COG0753	catalase activity
ESP47_08760	COG0671	phosphoesterase, PA-phosphatase related
ESP47_08770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ESP47_08790	COG1595	DNA-templated transcription, initiation
ESP47_08795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ESP47_08810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ESP47_08820	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ESP47_08825	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_08830	COG2211	Major facilitator Superfamily
ESP47_08835	COG1904	glucuronate isomerase
ESP47_08840	COG2721	sulfolactate sulfo-lyase activity
ESP47_08845	COG0246	Mannitol dehydrogenase
ESP47_08855	COG0800	Aldolase
ESP47_08860	COG1414	Transcriptional regulator
ESP47_08925	COG0557	exoribonuclease II activity
ESP47_08930	COG1647	Serine aminopeptidase, S33
ESP47_08935	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ESP47_08950	COG0148	phosphopyruvate hydratase activity
ESP47_08955	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ESP47_08965	COG0126	phosphoglycerate kinase activity
ESP47_08985	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ESP47_09000	COG3383	formate dehydrogenase (NAD+) activity
ESP47_09010	COG0840	transmembrane signaling receptor activity
ESP47_09040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ESP47_09055	COG4608	Belongs to the ABC transporter superfamily
ESP47_09060	COG0791	NLP P60 protein
ESP47_09065	COG4166	transmembrane transport
ESP47_09070	COG0444	Belongs to the ABC transporter superfamily
ESP47_09075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ESP47_09080	COG0601	transmembrane transport
ESP47_09085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ESP47_09095	COG0598	Magnesium transport protein CorA
ESP47_09110	COG2719	SpoVR family
ESP47_09115	COG3594	Acyltransferase
ESP47_09140	COG1392	Phosphate transport regulator
ESP47_09145	COG0306	phosphate transporter
ESP47_09160	COG2718	Belongs to the UPF0229 family
ESP47_09165	COG2766	serine protein kinase
ESP47_09175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ESP47_09190	COG2095	MarC family integral membrane protein
ESP47_09200	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ESP47_09205	COG0596	Alpha beta hydrolase
ESP47_09210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP47_09215	COG0765	amino acid transport
ESP47_09220	COG1126	abc transporter atp-binding protein
ESP47_09225	COG2116	formate transmembrane transporter activity
ESP47_09245	COG1882	Formate acetyltransferase
ESP47_09250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ESP47_09255	COG0431	NADPH-dependent FMN reductase
ESP47_09270	COG1131	(ABC) transporter
ESP47_09310	COG0745	RESPONSE REGULATOR receiver
ESP47_09315	COG5002	protein histidine kinase activity
ESP47_09315	COG3850	Histidine kinase
ESP47_09325	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ESP47_09335	COG2188	Transcriptional regulator
ESP47_09340	COG3104	oligopeptide transport
ESP47_09345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ESP47_09350	COG1131	(ABC) transporter
ESP47_09355	COG4555	ABC transporter
ESP47_09375	COG1846	Transcriptional regulator
ESP47_09395	COG1136	(ABC) transporter
ESP47_09395	COG0577	efflux transmembrane transporter activity
ESP47_09425	COG2271	Major facilitator Superfamily
ESP47_09435	COG0697	spore germination
ESP47_09450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESP47_09560	COG3527	Alpha-acetolactate decarboxylase
ESP47_09565	COG0028	Belongs to the TPP enzyme family
ESP47_09570	COG0583	DNA-binding transcription factor activity
ESP47_09575	COG0735	belongs to the Fur family
ESP47_09590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ESP47_09595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ESP47_09600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESP47_09605	COG1116	anion transmembrane transporter activity
ESP47_09610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ESP47_09615	COG2814	Major facilitator Superfamily
ESP47_09635	COG1737	Transcriptional regulator
ESP47_09640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_09640	COG1263	PTS System
ESP47_09645	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ESP47_09655	COG1132	(ABC) transporter
ESP47_09660	COG3557	Belongs to the UPF0374 family
ESP47_09675	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_09680	COG0583	DNA-binding transcription factor activity
ESP47_09685	COG0070	glutamate synthase
ESP47_09685	COG0067	glutamate synthase
ESP47_09685	COG0069	glutamate synthase activity
ESP47_09690	COG0493	'glutamate synthase
ESP47_09710	COG1131	(ABC) transporter
ESP47_09720	COG1988	membrane-bound metal-dependent
ESP47_09725	COG1194	a g-specific adenine glycosylase
ESP47_09760	COG0159	tryptophan synthase activity
ESP47_09770	COG0133	tryptophan synthase activity
ESP47_09775	COG0134	indole-3-glycerol-phosphate synthase activity
ESP47_09780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ESP47_09785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ESP47_09785	COG0512	Glutamine amidotransferase of anthranilate synthase
ESP47_09795	COG0577	efflux transmembrane transporter activity
ESP47_09800	COG0577	efflux transmembrane transporter activity
ESP47_09800	COG1136	(ABC) transporter
ESP47_09805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ESP47_09825	COG1131	(ABC) transporter
ESP47_09860	COG2197	response regulator
ESP47_09865	COG4585	Histidine kinase
ESP47_09875	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_09875	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_09885	COG0058	SHG alpha-glucan phosphorylase activity
ESP47_09890	COG0840	transmembrane signaling receptor activity
ESP47_09895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ESP47_09900	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ESP47_09905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ESP47_09920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ESP47_09925	COG0066	3-isopropylmalate dehydratase activity
ESP47_09930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ESP47_09940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ESP47_09945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ESP47_09950	COG0440	acetolactate synthase activity
ESP47_09955	COG0028	Belongs to the TPP enzyme family
ESP47_09960	COG0129	dihydroxy-acid dehydratase activity
ESP47_09970	COG1114	Component of the transport system for branched-chain amino acids
ESP47_09975	COG1366	Belongs to the anti-sigma-factor antagonist family
ESP47_09985	COG2124	cytochrome p450
ESP47_09990	COG0670	Belongs to the BI1 family
ESP47_09995	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ESP47_10000	COG2223	nitrite transmembrane transporter activity
ESP47_10005	COG3279	Response regulator of the LytR AlgR family
ESP47_10010	COG3275	phosphorelay sensor kinase activity
ESP47_10015	COG0252	asparaginase activity
ESP47_10020	COG2132	Multicopper oxidase
ESP47_10025	COG1309	transcriptional regulator
ESP47_10030	COG1511	domain protein
ESP47_10060	COG5278	phosphoserine phosphatase activity
ESP47_10060	COG0840	transmembrane signaling receptor activity
ESP47_10065	COG3739	integral membrane protein
ESP47_10070	COG3655	Transcriptional regulator
ESP47_10085	COG1823	symporter activity
ESP47_10090	COG2839	Protein conserved in bacteria
ESP47_10110	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
ESP47_10115	COG0477	Major facilitator Superfamily
ESP47_10120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ESP47_10125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ESP47_10130	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ESP47_10135	COG0840	transmembrane signaling receptor activity
ESP47_10150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ESP47_10155	COG1132	(ABC) transporter
ESP47_10160	COG1846	Transcriptional regulator
ESP47_10170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ESP47_10175	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ESP47_10195	COG0387	Pfam Sodium calcium exchanger
ESP47_10200	COG0477	Major facilitator Superfamily
ESP47_10205	COG1295	ribonuclease BN
ESP47_10210	COG4840	Belongs to the UPF0435 family
ESP47_10215	COG0024	Methionine aminopeptidase
ESP47_10220	COG0693	protein deglycase activity
ESP47_10225	COG1360	Flagellar Motor Protein
ESP47_10230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ESP47_10240	COG3189	MarR family transcriptional regulator
ESP47_10250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ESP47_10255	COG1607	acyl-coa hydrolase
ESP47_10260	COG1077	Cell shape determining protein MreB Mrl
ESP47_10265	COG2268	Band 7 protein
ESP47_10270	COG1585	Membrane protein implicated in regulation of membrane protease activity
ESP47_10275	COG0626	cystathionine gamma-synthase activity
ESP47_10280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ESP47_10285	COG1854	S-ribosylhomocysteine lyase activity
ESP47_10290	COG2226	methyltransferase
ESP47_10295	COG0288	reversible hydration of carbon dioxide
ESP47_10300	COG0860	N-Acetylmuramoyl-L-alanine amidase
ESP47_10310	COG2197	response regulator
ESP47_10330	COG4086	secreted protein
ESP47_10335	COG0737	Belongs to the 5'-nucleotidase family
ESP47_10350	COG3620	sequence-specific DNA binding
ESP47_10355	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ESP47_10360	COG1518	maintenance of DNA repeat elements
ESP47_10410	COG1304	FMN binding
ESP47_10420	COG0166	Belongs to the GPI family
ESP47_10425	COG0025	NhaP-type Na H and K H
ESP47_10430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ESP47_10430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ESP47_10430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_10435	COG1349	DNA-binding transcription factor activity
ESP47_10440	COG0371	Dehydrogenase
ESP47_10455	COG0561	phosphatase activity
ESP47_10470	COG2814	Major facilitator Superfamily
ESP47_10475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ESP47_10490	COG2357	RelA SpoT domain protein
ESP47_10495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ESP47_10500	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ESP47_10505	COG1461	Dihydroxyacetone kinase
ESP47_10510	COG2376	Dihydroxyacetone kinase
ESP47_10520	COG0778	Nitroreductase
ESP47_10525	COG1113	amino acid transport
ESP47_10530	COG0730	response to heat
ESP47_10535	COG2233	PERMEase
ESP47_10545	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ESP47_10570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ESP47_10575	COG1024	Enoyl-CoA hydratase
ESP47_10580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ESP47_10585	COG0511	ligase activity, forming carbon-carbon bonds
ESP47_10590	COG0439	Biotin carboxylase
ESP47_10595	COG1960	acyl-CoA dehydrogenase activity
ESP47_10600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ESP47_10615	COG1349	DNA-binding transcription factor activity
ESP47_10625	COG2376	Dihydroxyacetone kinase
ESP47_10635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ESP47_10645	COG2271	Major facilitator Superfamily
ESP47_10655	COG1250	3-hydroxyacyl-CoA dehydrogenase
ESP47_10665	COG0698	ribose 5-phosphate isomerase
ESP47_10670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ESP47_10675	COG1494	fructose-1,6-bisphosphatase
ESP47_10680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ESP47_10690	COG3829	transcription factor binding
ESP47_10695	COG0833	amino acid
ESP47_10735	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ESP47_10740	COG1140	nitrate reductase beta subunit
ESP47_10750	COG2181	nitrate reductase activity
ESP47_10755	COG2223	nitrite transmembrane transporter activity
ESP47_10760	COG3588	fructose-bisphosphate aldolase
ESP47_10780	COG4268	DNA restriction-modification system
ESP47_10785	COG1401	restriction endodeoxyribonuclease activity
ESP47_10790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ESP47_10860	COG0583	DNA-binding transcription factor activity
ESP47_10865	COG0431	NADPH-dependent FMN reductase
ESP47_10870	COG0454	-acetyltransferase
ESP47_10875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP47_10880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP47_10885	COG0765	amino acid transport
ESP47_10890	COG0765	amino acid transport
ESP47_10895	COG1126	abc transporter atp-binding protein
ESP47_10900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESP47_10905	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ESP47_10910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESP47_10920	COG0386	Belongs to the glutathione peroxidase family
ESP47_10925	COG2190	(PTS) system
ESP47_10940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_10940	COG1263	PTS System
ESP47_10945	COG0517	IMP dehydrogenase activity
ESP47_10945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ESP47_10955	COG0281	malic enzyme
ESP47_10970	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_10975	COG1301	dicarboxylic acid transport
ESP47_10985	COG1328	CTP reductase activity
ESP47_10995	COG1063	alcohol dehydrogenase
ESP47_11000	COG3835	regulator
ESP47_11005	COG1929	Belongs to the glycerate kinase type-1 family
ESP47_11010	COG2610	gluconate transmembrane transporter activity
ESP47_11015	COG1879	ABC-type sugar transport system periplasmic component
ESP47_11020	COG1172	Belongs to the binding-protein-dependent transport system permease family
ESP47_11025	COG1129	ABC transporter
ESP47_11030	COG1869	D-ribose catabolic process
ESP47_11035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ESP47_11040	COG1609	Transcriptional regulator
ESP47_11080	COG4549	nuclear export factor GLE1
ESP47_11085	COG1276	copper resistance
ESP47_11085	COG2372	response to copper ion
ESP47_11095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ESP47_11100	COG1609	Transcriptional regulator
ESP47_11115	COG5002	protein histidine kinase activity
ESP47_11120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ESP47_11125	COG1278	Cold shock
ESP47_11130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ESP47_11150	COG0697	spore germination
ESP47_11155	COG1472	Belongs to the glycosyl hydrolase 3 family
ESP47_11170	COG3876	Protein conserved in bacteria
ESP47_11195	COG1132	(ABC) transporter
ESP47_11200	COG1132	(ABC) transporter
ESP47_11220	COG1388	LysM domain
ESP47_11220	COG0791	NLP P60 protein
ESP47_11240	COG2272	Belongs to the type-B carboxylesterase lipase family
ESP47_11245	COG0154	amidase activity
ESP47_11250	COG2814	Major facilitator Superfamily
ESP47_11255	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_11295	COG3153	acetyltransferase
ESP47_11295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ESP47_11300	COG5583	Uncharacterized small protein (DUF2292)
ESP47_11305	COG0431	NADPH-dependent FMN reductase
ESP47_11310	COG1116	anion transmembrane transporter activity
ESP47_11315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESP47_11320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESP47_11325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ESP47_11360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ESP47_11375	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ESP47_11385	COG2390	Transcriptional regulator
ESP47_11395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ESP47_11410	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ESP47_11425	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ESP47_11430	COG1984	allophanate hydrolase subunit 2
ESP47_11435	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ESP47_11440	COG2814	Major facilitator Superfamily
ESP47_11445	COG1764	response to oxidative stress
ESP47_11450	COG1126	abc transporter atp-binding protein
ESP47_11455	COG0765	amino acid transport
ESP47_11460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP47_11470	COG0326	Molecular chaperone. Has ATPase activity
ESP47_11540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ESP47_11555	COG1064	alcohol dehydrogenase
ESP47_11580	COG2814	Major facilitator Superfamily
ESP47_11585	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_11625	COG3716	PTS system mannose fructose sorbose family IID component
ESP47_11705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ESP47_11710	COG1597	lipid kinase activity
ESP47_11735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ESP47_11740	COG0154	amidase activity
ESP47_11745	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ESP47_11750	COG2224	Isocitrate lyase
ESP47_11755	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ESP47_11760	COG4851	CamS sex pheromone cAM373 precursor
ESP47_11770	COG0210	DNA helicase
ESP47_11775	COG0210	DNA helicase
ESP47_11780	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ESP47_11785	COG4496	protein, YerC YecD
ESP47_11790	COG1470	cell adhesion involved in biofilm formation
ESP47_11805	COG0151	Belongs to the GarS family
ESP47_11815	COG0138	bifunctional purine biosynthesis protein purh
ESP47_11820	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ESP47_11825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ESP47_11830	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ESP47_11835	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ESP47_11840	COG0047	phosphoribosylformylglycinamidine synthase activity
ESP47_11845	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ESP47_11855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ESP47_11860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ESP47_11865	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ESP47_11875	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ESP47_11880	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ESP47_11885	COG2190	(PTS) system
ESP47_11885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_11885	COG1263	PTS System
ESP47_11900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_11900	COG1263	PTS System
ESP47_11925	COG1301	dicarboxylic acid transport
ESP47_11935	COG3711	transcriptional antiterminator
ESP47_11945	COG2252	PERMEase
ESP47_11955	COG1132	(ABC) transporter
ESP47_11960	COG2814	Major facilitator Superfamily
ESP47_11965	COG2197	response regulator
ESP47_11970	COG3850	Histidine kinase
ESP47_11975	COG1131	(ABC) transporter
ESP47_11985	COG0842	Transport permease protein
ESP47_12000	COG0179	Fumarylacetoacetate (FAA) hydrolase
ESP47_12020	COG0824	Thioesterase
ESP47_12025	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_12030	COG0183	Belongs to the thiolase family
ESP47_12040	COG1250	3-hydroxyacyl-CoA dehydrogenase
ESP47_12045	COG2508	Transcriptional regulator
ESP47_12050	COG2814	Major facilitator Superfamily
ESP47_12060	COG0179	Fumarylacetoacetate (FAA) hydrolase
ESP47_12070	COG0471	metal ion transport
ESP47_12095	COG1131	(ABC) transporter
ESP47_12100	COG1725	Transcriptional regulator
ESP47_12105	COG1695	Transcriptional regulator
ESP47_12110	COG3479	Phenolic acid decarboxylase
ESP47_12115	COG2910	NAD(P)H-binding
ESP47_12120	COG1959	2 iron, 2 sulfur cluster binding
ESP47_12145	COG0425	Belongs to the sulfur carrier protein TusA family
ESP47_12150	COG2391	methyltransferase activity
ESP47_12160	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_12180	COG1120	ATPase activity
ESP47_12185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ESP47_12215	COG3620	sequence-specific DNA binding
ESP47_12230	COG0519	Catalyzes the synthesis of GMP from XMP
ESP47_12230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ESP47_12235	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ESP47_12240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ESP47_12245	COG1335	isochorismatase
ESP47_12250	COG4948	Mandelate Racemase Muconate Lactonizing
ESP47_12260	COG0463	Glycosyl transferase, family 2
ESP47_12265	COG2246	polysaccharide biosynthetic process
ESP47_12270	COG0459	protein refolding
ESP47_12275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ESP47_12280	COG1266	CAAX protease self-immunity
ESP47_12290	COG0805	protein transport
ESP47_12295	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ESP47_12300	COG0488	(ABC) transporter
ESP47_12310	COG0456	acetyltransferase
ESP47_12315	COG1214	PFAM Peptidase M22, glycoprotease
ESP47_12320	COG0802	atpase or kinase
ESP47_12405	COG3091	SprT-like family
ESP47_12415	COG2183	response to ionizing radiation
ESP47_12420	COG2208	phosphoserine phosphatase activity
ESP47_12425	COG1191	sigma factor activity
ESP47_12430	COG2172	sigma factor antagonist activity
ESP47_12435	COG1366	Belongs to the anti-sigma-factor antagonist family
ESP47_12445	COG2172	sigma factor antagonist activity
ESP47_12450	COG1366	Belongs to the anti-sigma-factor antagonist family
ESP47_12455	COG1366	Belongs to the anti-sigma-factor antagonist family
ESP47_12465	COG2337	Toxic component of a toxin-antitoxin (TA) module
ESP47_12470	COG0864	Transcriptional regulator
ESP47_12480	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ESP47_12485	COG0736	holo-[acyl-carrier-protein] synthase activity
ESP47_12490	COG0705	Rhomboid family
ESP47_12495	COG0513	Belongs to the DEAD box helicase family
ESP47_12505	COG1280	lysine exporter protein (LysE YggA)
ESP47_12515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESP47_12520	COG1609	Transcriptional regulator
ESP47_12525	COG0366	Alpha amylase catalytic
ESP47_12535	COG2182	Extracellular solute-binding protein
ESP47_12540	COG1175	transmembrane transport
ESP47_12545	COG3833	ABC-type maltose transport systems, permease component
ESP47_12555	COG1554	hydrolase, family 65, central catalytic
ESP47_12565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ESP47_12570	COG1181	Belongs to the D-alanine--D-alanine ligase family
ESP47_12580	COG1253	flavin adenine dinucleotide binding
ESP47_12585	COG0789	Transcriptional regulator
ESP47_12590	COG1253	flavin adenine dinucleotide binding
ESP47_12605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ESP47_12620	COG0629	single-stranded DNA binding
ESP47_12625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ESP47_12630	COG4786	Flagellar basal body rod
ESP47_12635	COG4786	Flagellar basal body rod
ESP47_12640	COG1077	Cell shape determining protein MreB Mrl
ESP47_12645	COG1609	Transcriptional regulator
ESP47_12650	COG0739	heme binding
ESP47_12655	COG2385	sporulation resulting in formation of a cellular spore
ESP47_12665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ESP47_12675	COG4836	Membrane
ESP47_12680	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ESP47_12685	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ESP47_12690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ESP47_12695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ESP47_12700	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ESP47_12710	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ESP47_12715	COG0356	it plays a direct role in the translocation of protons across the membrane
ESP47_12725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ESP47_12730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ESP47_12740	COG0698	ribose 5-phosphate isomerase
ESP47_12755	COG1971	Probably functions as a manganese efflux pump
ESP47_12760	COG0009	L-threonylcarbamoyladenylate synthase
ESP47_12775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ESP47_12785	COG1435	thymidine kinase activity
ESP47_12790	COG0254	rRNA binding
ESP47_12795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ESP47_12800	COG1494	fructose-1,6-bisphosphatase
ESP47_12805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ESP47_12810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ESP47_12815	COG0191	fructose-bisphosphate aldolase activity
ESP47_12820	COG2204	response regulator
ESP47_12835	COG1131	(ABC) transporter
ESP47_12840	COG1725	Transcriptional regulator
ESP47_12845	COG0504	CTP synthase activity
ESP47_12850	COG3343	RNA polymerase activity
ESP47_12860	COG1136	(ABC) transporter
ESP47_12870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ESP47_12870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ESP47_12870	COG1703	isobutyryl-CoA mutase activity
ESP47_12875	COG1309	transcriptional regulator
ESP47_12880	COG1960	acyl-CoA dehydrogenase activity
ESP47_12885	COG1960	acyl-CoA dehydrogenase activity
ESP47_12890	COG0183	Belongs to the thiolase family
ESP47_12895	COG2181	nitrate reductase activity
ESP47_12895	COG0247	lactate metabolic process
ESP47_12900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ESP47_12905	COG0018	arginyl-trna synthetase
ESP47_12915	COG0010	Belongs to the arginase family
ESP47_12920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ESP47_12930	COG1994	Peptidase M50
ESP47_12940	COG3465	dGTPase activity
ESP47_12945	COG1078	dGTPase activity
ESP47_12955	COG0095	Lipoate-protein ligase
ESP47_12960	COG0280	phosphate acetyltransferase
ESP47_12965	COG3253	May function as heme-dependent peroxidase
ESP47_12975	COG2363	Small membrane protein
ESP47_12985	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ESP47_13015	COG4555	ABC transporter
ESP47_13030	COG1121	(ABC) transporter
ESP47_13040	COG0351	phosphomethylpyrimidine kinase
ESP47_13055	COG0561	phosphatase activity
ESP47_13060	COG0514	ATP-dependent DNA helicase (RecQ)
ESP47_13065	COG1785	Belongs to the alkaline phosphatase family
ESP47_13070	COG1737	Transcriptional regulator
ESP47_13080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ESP47_13085	COG1346	cytolysis
ESP47_13090	COG1380	Effector of murein hydrolase LrgA
ESP47_13095	COG0583	DNA-binding transcription factor activity
ESP47_13100	COG0367	asparagine synthase
ESP47_13125	COG2966	Psort location CytoplasmicMembrane, score
ESP47_13130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ESP47_13135	COG1966	Carbon starvation protein
ESP47_13145	COG3275	phosphorelay sensor kinase activity
ESP47_13150	COG1464	Belongs to the NlpA lipoprotein family
ESP47_13155	COG2011	ABC-type metal ion transport system permease component
ESP47_13160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ESP47_13165	COG1119	ATPase activity
ESP47_13180	COG0534	Mate efflux family protein
ESP47_13185	COG1442	glycosyl transferase family 8
ESP47_13190	COG2195	Cleaves the N-terminal amino acid of tripeptides
ESP47_13195	COG2814	Major facilitator Superfamily
ESP47_13205	COG0028	Belongs to the TPP enzyme family
ESP47_13210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ESP47_13220	COG1132	(ABC) transporter
ESP47_13230	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ESP47_13250	COG2188	Transcriptional regulator
ESP47_13255	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ESP47_13260	COG1366	Belongs to the anti-sigma-factor antagonist family
ESP47_13265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP47_13270	COG0765	amino acid transport
ESP47_13275	COG1126	abc transporter atp-binding protein
ESP47_13295	COG3457	Alanine racemase
ESP47_13305	COG1126	abc transporter atp-binding protein
ESP47_13315	COG0765	amino acid transport
ESP47_13330	COG0579	oxidoreductase
ESP47_13335	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ESP47_13340	COG0732	type I restriction modification DNA specificity domain
ESP47_13425	COG1280	lysine exporter protein (LysE YggA)
ESP47_13435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ESP47_13460	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ESP47_13470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ESP47_13475	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ESP47_13480	COG4853	Protein conserved in bacteria
ESP47_13485	COG4863	YycH protein
ESP47_13490	COG5002	protein histidine kinase activity
ESP47_13495	COG0745	RESPONSE REGULATOR receiver
ESP47_13510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ESP47_13515	COG0305	Participates in initiation and elongation during chromosome replication
ESP47_13520	COG0359	binds to the 23S rRNA
ESP47_13525	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ESP47_13535	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ESP47_13545	COG0360	Binds together with S18 to 16S ribosomal RNA
ESP47_13550	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ESP47_13555	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ESP47_13555	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ESP47_13560	COG0307	riboflavin synthase, alpha
ESP47_13565	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ESP47_13565	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ESP47_13570	COG0012	GTP binding
ESP47_13575	COG4481	Protein conserved in bacteria
ESP47_13580	COG0668	transmembrane transport
ESP47_13595	COG1475	DNA binding
ESP47_13600	COG1192	Involved in chromosome partitioning
ESP47_13605	COG1475	DNA binding
ESP47_13610	COG0357	Ribosomal RNA small subunit methyltransferase G
ESP47_13615	COG0445	tRNA wobble uridine modification
ESP47_13620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ESP47_13625	COG1847	R3H domain protein
ESP47_13630	COG0706	membrane insertase activity
ESP47_13635	COG0594	ribonuclease P activity
ESP47_13640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ESP47_13645	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ESP47_13650	COG0592	DNA-directed DNA polymerase activity
ESP47_13655	COG2501	S4 domain
ESP47_13660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ESP47_13670	COG0187	DNA topoisomerase II activity
ESP47_13675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ESP47_13680	COG3437	response regulator, receiver
ESP47_13720	COG1982	Orn Lys Arg decarboxylase major
ESP47_13730	COG3870	Protein conserved in bacteria
ESP47_13735	COG1728	Protein conserved in bacteria
ESP47_13740	COG0470	DNA polymerase III
ESP47_13745	COG1774	PSP1 C-terminal conserved region
ESP47_13750	COG4467	Involved in initiation control of chromosome replication
ESP47_13755	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ESP47_13760	COG2827	Endonuclease containing a URI domain
ESP47_13765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ESP47_13770	COG2002	toxin-antitoxin pair type II binding
ESP47_13780	COG0084	hydrolase, TatD family'
ESP47_13790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ESP47_13800	COG4466	Protein conserved in bacteria
ESP47_13810	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ESP47_13815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ESP47_13820	COG0251	oxidation-reduction process
ESP47_13850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ESP47_13855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ESP47_13860	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ESP47_13865	COG0193	aminoacyl-tRNA hydrolase activity
ESP47_13875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ESP47_13880	COG2002	toxin-antitoxin pair type II binding
ESP47_13885	COG2244	polysaccharide biosynthetic process
ESP47_13890	COG3956	TIGRFAM MazG family protein
ESP47_13895	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ESP47_13915	COG1098	S1 RNA binding domain
ESP47_13925	COG2208	phosphoserine phosphatase activity
ESP47_13930	COG2304	oxidoreductase activity
ESP47_13935	COG0515	serine threonine protein kinase
ESP47_13940	COG0037	tRNA processing
ESP47_13945	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ESP47_13950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ESP47_13955	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ESP47_13960	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ESP47_13965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ESP47_13970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ESP47_13975	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ESP47_13980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ESP47_14060	COG0516	GMP reductase activity
ESP47_14060	COG0517	IMP dehydrogenase activity
ESP47_14075	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ESP47_14085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ESP47_14095	COG1428	Deoxynucleoside kinase
ESP47_14100	COG1428	Deoxynucleoside kinase
ESP47_14105	COG3858	chitin binding
ESP47_14105	COG1388	LysM domain
ESP47_14135	COG0590	tRNA wobble adenosine to inosine editing
ESP47_14145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ESP47_14150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ESP47_14155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ESP47_14205	COG3880	PFAM UvrB UvrC protein
ESP47_14210	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ESP47_14215	COG0542	response to heat
ESP47_14220	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ESP47_14225	COG4956	integral membrane protein (PIN domain superfamily)
ESP47_14235	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ESP47_14240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ESP47_14245	COG1045	serine acetyltransferase
ESP47_14250	COG0215	cysteine-tRNA ligase activity
ESP47_14260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ESP47_14265	COG3688	RNA-binding protein containing a PIN domain
ESP47_14275	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ESP47_14280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ESP47_14285	COG0250	Participates in transcription elongation, termination and antitermination
ESP47_14290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ESP47_14295	COG0081	regulation of translation
ESP47_14300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ESP47_14305	COG0222	ribosome binding
ESP47_14310	COG2813	Specifically methylates the guanine in position
ESP47_14325	COG1358	cellular component organization or biogenesis
ESP47_14330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ESP47_14335	COG0049	tRNA binding
ESP47_14340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ESP47_14345	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ESP47_14350	COG0051	transcription antitermination factor activity, RNA binding
ESP47_14360	COG0088	Forms part of the polypeptide exit tunnel
ESP47_14365	COG0089	rRNA binding
ESP47_14370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ESP47_14375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ESP47_14385	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ESP47_14390	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ESP47_14395	COG0255	Belongs to the universal ribosomal protein uL29 family
ESP47_14400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ESP47_14405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ESP47_14410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ESP47_14420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ESP47_14425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ESP47_14430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ESP47_14435	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ESP47_14440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ESP47_14450	COG0200	Binds to the 23S rRNA
ESP47_14455	COG0201	protein transport
ESP47_14460	COG0563	adenylate kinase activity
ESP47_14465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ESP47_14470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ESP47_14475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ESP47_14480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ESP47_14485	COG0202	RNA polymerase activity
ESP47_14490	COG0203	ribosomal protein L17
ESP47_14495	COG1122	ATPase activity
ESP47_14500	COG1122	ATPase activity
ESP47_14505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ESP47_14515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ESP47_14520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ESP47_14535	COG2046	Belongs to the sulfate adenylyltransferase family
ESP47_14540	COG0529	Catalyzes the synthesis of activated sulfate
ESP47_14545	COG0833	amino acid
ESP47_14555	COG0860	N-Acetylmuramoyl-L-alanine amidase
ESP47_14560	COG0489	protein tyrosine kinase activity
ESP47_14570	COG2194	sulfuric ester hydrolase activity
ESP47_14585	COG0726	polysaccharide deacetylase
ESP47_14595	COG1271	oxidase subunit
ESP47_14600	COG1294	oxidase, subunit
ESP47_14610	COG4988	ABC transporter
ESP47_14615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ESP47_14620	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_14695	COG1525	nuclease
ESP47_14715	COG3620	sequence-specific DNA binding
ESP47_14760	COG5377	YqaJ viral recombinase family
ESP47_14765	COG3723	Recombinational DNA repair protein, rece pathway
ESP47_14770	COG3935	DnaD domain protein
ESP47_14780	COG0305	Participates in initiation and elongation during chromosome replication
ESP47_14940	COG1388	LysM domain
ESP47_14940	COG3942	CHAP domain
ESP47_14955	COG1595	DNA-templated transcription, initiation
ESP47_14960	COG5662	AntiSigma factor
ESP47_14965	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ESP47_14970	COG4856	YbbR-like protein
ESP47_14975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ESP47_14980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ESP47_15050	COG2814	Major facilitator Superfamily
ESP47_15055	COG0583	DNA-binding transcription factor activity
ESP47_15065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ESP47_15075	COG0840	transmembrane signaling receptor activity
ESP47_15090	COG1695	Transcriptional regulator
ESP47_15095	COG0840	transmembrane signaling receptor activity
ESP47_15100	COG0477	Major facilitator Superfamily
ESP47_15160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ESP47_15165	COG2814	Major facilitator Superfamily
ESP47_15175	COG0519	Catalyzes the synthesis of GMP from XMP
ESP47_15200	COG2814	Major facilitator Superfamily
ESP47_15200	COG0477	Major facilitator Superfamily
ESP47_15250	COG3425	synthase
ESP47_15265	COG0183	Belongs to the thiolase family
ESP47_15295	COG1125	glycine betaine transport
ESP47_15295	COG0517	IMP dehydrogenase activity
ESP47_15300	COG1174	glycine betaine transport
ESP47_15305	COG2190	(PTS) system
ESP47_15310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_15310	COG1263	PTS System
ESP47_15315	COG0366	Alpha amylase catalytic
ESP47_15320	COG2188	Transcriptional regulator
ESP47_15330	COG1070	Carbohydrate kinase
ESP47_15340	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ESP47_15345	COG0716	FMN binding
ESP47_15360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ESP47_15370	COG2217	Heavy metal translocating P-type atpase
ESP47_15385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ESP47_15395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ESP47_15400	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ESP47_15405	COG0463	Glycosyl transferase, family 2
ESP47_15435	COG2076	Multidrug Resistance protein
ESP47_15440	COG2076	Multidrug Resistance protein
ESP47_15455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ESP47_15460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ESP47_15465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ESP47_15470	COG1120	ATPase activity
ESP47_15495	COG0217	transcriptional regulatory protein
ESP47_15500	COG1366	Belongs to the anti-sigma-factor antagonist family
ESP47_15510	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_15520	COG1309	transcriptional regulator
ESP47_15540	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_15560	COG5434	Belongs to the glycosyl hydrolase 28 family
ESP47_15570	COG0175	sulfate reduction
ESP47_15590	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ESP47_15600	COG0371	Dehydrogenase
ESP47_15605	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_15620	COG0697	spore germination
ESP47_15640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ESP47_15650	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ESP47_15665	COG0702	epimerase
ESP47_15685	COG2213	PTS system mannitol-specific
ESP47_15685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_15690	COG3711	transcriptional antiterminator
ESP47_15695	COG0246	Mannitol dehydrogenase
ESP47_15700	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ESP47_15720	COG2848	UPF0210 protein
ESP47_15725	COG1609	Transcriptional regulator
ESP47_15740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ESP47_15755	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ESP47_15765	COG5577	PFAM Coat F domain
ESP47_15770	COG0667	Aldo Keto reductase
ESP47_15780	COG1113	amino acid transport
ESP47_15790	COG3104	oligopeptide transport
ESP47_15795	COG0833	amino acid
ESP47_15805	COG3842	ATPase activity
ESP47_15810	COG1176	ABC-type spermidine putrescine transport system, permease component I
ESP47_15870	COG0531	amino acid
ESP47_15875	COG1556	Lactate utilization protein
ESP47_15880	COG1139	Iron-sulfur cluster binding protein
ESP47_15885	COG0247	lactate metabolic process
ESP47_15895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ESP47_15900	COG1454	alcohol dehydrogenase
ESP47_15910	COG1953	Uracil, thiamine, allantoin
ESP47_15935	COG0531	amino acid
ESP47_15940	COG1979	alcohol dehydrogenase
ESP47_15945	COG0004	ammonium transporteR
ESP47_15950	COG3290	protein histidine kinase activity
ESP47_15955	COG4565	transcriptional regulatory protein
ESP47_15960	COG2851	Citrate transporter
ESP47_15965	COG0463	Glycosyl transferase, family 2
ESP47_15970	COG3973	AAA domain
ESP47_15985	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ESP47_15995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ESP47_16000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ESP47_16005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ESP47_16010	COG1301	dicarboxylic acid transport
ESP47_16015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ESP47_16050	COG1902	pentaerythritol trinitrate reductase activity
ESP47_16070	COG0423	glycine-tRNA ligase activity
ESP47_16075	COG0531	amino acid
ESP47_16085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ESP47_16090	COG0628	permease
ESP47_16105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ESP47_16110	COG0765	amino acid transport
ESP47_16115	COG0765	amino acid transport
ESP47_16130	COG1733	regulation of RNA biosynthetic process
ESP47_16140	COG0586	Pfam SNARE associated Golgi protein
ESP47_16145	COG0586	Pfam SNARE associated Golgi protein
ESP47_16160	COG0646	methionine synthase
ESP47_16160	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ESP47_16165	COG0646	methionine synthase
ESP47_16165	COG1410	methionine synthase
ESP47_16195	COG3944	biosynthesis protein
ESP47_16200	COG0489	protein tyrosine kinase activity
ESP47_16205	COG4464	protein tyrosine phosphatase activity
ESP47_16210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ESP47_16215	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ESP47_16250	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ESP47_16250	COG0662	Cupin 2, conserved barrel domain protein
ESP47_16255	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ESP47_16285	COG1501	Belongs to the glycosyl hydrolase 31 family
ESP47_16295	COG2115	Belongs to the xylose isomerase family
ESP47_16300	COG1070	Carbohydrate kinase
ESP47_16330	COG1070	Carbohydrate kinase
ESP47_16340	COG1940	carbohydrate kinase activity
ESP47_16345	COG1063	alcohol dehydrogenase
ESP47_16370	COG4193	domain, Protein
ESP47_16390	COG5504	Zn-dependent protease
ESP47_16395	COG2226	methyltransferase
ESP47_16445	COG3716	PTS system mannose fructose sorbose family IID component
ESP47_16450	COG3715	PTS system
ESP47_16455	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_16460	COG0363	glucosamine-6-phosphate deaminase activity
ESP47_16465	COG2188	Transcriptional regulator
ESP47_16470	COG1396	sequence-specific DNA binding
ESP47_16480	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
ESP47_16485	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ESP47_16490	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ESP47_16490	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ESP47_16500	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_16500	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_16505	COG3715	PTS system
ESP47_16510	COG3716	PTS system mannose fructose sorbose family IID component
ESP47_16530	COG3414	Phosphotransferase system galactitol-specific IIB component
ESP47_16535	COG3775	system Galactitol-specific IIC component
ESP47_16545	COG1105	Belongs to the carbohydrate kinase PfkB family
ESP47_16550	COG0235	Class ii aldolase
ESP47_16570	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ESP47_16580	COG0145	ligase activity
ESP47_16590	COG2315	Protein conserved in bacteria
ESP47_16600	COG0658	competence protein
ESP47_16600	COG2333	competence protein COMEC
ESP47_16625	COG0531	amino acid
ESP47_16630	COG1316	TRANSCRIPTIONal
ESP47_16640	COG4989	oxidoreductase activity
ESP47_16670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ESP47_16675	COG2130	NADP-dependent
ESP47_16685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_16685	COG3711	transcriptional antiterminator
ESP47_16690	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ESP47_16695	COG1447	Phosphotransferase system cellobiose-specific component IIA
ESP47_16705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ESP47_16710	COG2190	(PTS) system
ESP47_16710	COG2211	Major facilitator Superfamily
ESP47_16715	COG1113	amino acid transport
ESP47_16730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ESP47_16740	COG2814	Major facilitator Superfamily
ESP47_16745	COG1609	Transcriptional regulator
ESP47_16755	COG1174	glycine betaine transport
ESP47_16760	COG1732	Glycine betaine
ESP47_16765	COG1174	glycine betaine transport
ESP47_16770	COG0517	IMP dehydrogenase activity
ESP47_16770	COG1125	glycine betaine transport
ESP47_16775	COG1510	regulation of RNA biosynthetic process
ESP47_16780	COG0110	maltose O-acetyltransferase activity
ESP47_16785	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_16805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ESP47_16825	COG2272	Belongs to the type-B carboxylesterase lipase family
ESP47_16830	COG0606	chelatase, subunit chli
ESP47_16840	COG0371	Dehydrogenase
ESP47_16845	COG2814	Major facilitator Superfamily
ESP47_16850	COG1070	Carbohydrate kinase
ESP47_16855	COG2115	Belongs to the xylose isomerase family
ESP47_16870	COG0157	Belongs to the NadC ModD family
ESP47_16875	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ESP47_16880	COG1104	cysteine desulfurase activity
ESP47_16890	COG2116	formate transmembrane transporter activity
ESP47_16920	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_16925	COG2610	gluconate transmembrane transporter activity
ESP47_16930	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_16940	COG3290	protein histidine kinase activity
ESP47_16940	COG3829	transcription factor binding
ESP47_16945	COG1501	Belongs to the glycosyl hydrolase 31 family
ESP47_16970	COG1309	transcriptional regulator
ESP47_16985	COG1363	Peptidase, m42
ESP47_17025	COG2972	Histidine kinase
ESP47_17045	COG0531	amino acid
ESP47_17055	COG1620	l-lactate permease
ESP47_17060	COG2186	Transcriptional regulator
ESP47_17115	COG1447	Phosphotransferase system cellobiose-specific component IIA
ESP47_17130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ESP47_17130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ESP47_17135	COG2723	6-phospho-beta-galactosidase activity
ESP47_17140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_17140	COG3711	transcriptional antiterminator
ESP47_17145	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ESP47_17155	COG1131	(ABC) transporter
ESP47_17165	COG0626	cystathionine gamma-synthase activity
ESP47_17170	COG0626	cystathionine gamma-synthase activity
ESP47_17190	COG1653	transport
ESP47_17195	COG2207	Transcriptional regulator
ESP47_17210	COG0604	alcohol dehydrogenase
ESP47_17215	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ESP47_17220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ESP47_17245	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_17250	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ESP47_17260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ESP47_17270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ESP47_17275	COG1316	TRANSCRIPTIONal
ESP47_17280	COG1136	(ABC) transporter
ESP47_17280	COG0577	efflux transmembrane transporter activity
ESP47_17295	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ESP47_17310	COG1388	LysM domain
ESP47_17310	COG3584	3D domain protein
ESP47_17320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ESP47_17330	COG0011	TIGRFAM Protein of
ESP47_17335	COG2706	6-phosphogluconolactonase activity
ESP47_17345	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ESP47_17345	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ESP47_17350	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESP47_17350	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ESP47_17360	COG3715	PTS system
ESP47_17365	COG3716	PTS system mannose fructose sorbose family IID component
ESP47_17380	COG2079	MmgE PrpD family protein
ESP47_17385	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ESP47_17395	COG0154	amidase activity
ESP47_17405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ESP47_17410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ESP47_17415	COG1116	anion transmembrane transporter activity
ESP47_17420	COG0083	homoserine kinase activity
ESP47_17425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ESP47_17430	COG0460	homoserine dehydrogenase
ESP47_17435	COG0010	Belongs to the arginase family
ESP47_17445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ESP47_17450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ESP47_17460	COG4145	pantothenate transmembrane transporter activity
ESP47_17480	COG1454	alcohol dehydrogenase
ESP47_17480	COG1012	belongs to the aldehyde dehydrogenase family
ESP47_17495	COG0791	NLP P60 protein
ESP47_17495	COG1388	LysM domain
ESP47_17500	COG0024	Methionine aminopeptidase
ESP47_17505	COG1268	BioY protein
ESP47_17515	COG0318	PFAM AMP-dependent synthetase and ligase
ESP47_17520	COG1960	acyl-CoA dehydrogenase activity
ESP47_17525	COG1028	Short-chain dehydrogenase reductase Sdr
ESP47_17530	COG2746	aminoglycoside 3-N-acetyltransferase activity
ESP47_17535	COG2244	polysaccharide biosynthetic process
ESP47_17540	COG0589	response to stress
ESP47_17555	COG0535	radical SAM domain protein
ESP47_17560	COG0457	Tetratricopeptide repeat
ESP47_17565	COG1063	alcohol dehydrogenase
ESP47_17580	COG1609	Transcriptional regulator
ESP47_17590	COG0561	phosphatase activity
ESP47_17610	COG0656	L-ascorbic acid biosynthetic process
ESP47_17620	COG0657	acetylesterase activity
ESP47_17625	COG0656	L-ascorbic acid biosynthetic process
ESP47_17630	COG0431	NADPH-dependent FMN reductase
ESP47_17635	COG0420	3'-5' exonuclease activity
ESP47_17640	COG4717	serine-type aminopeptidase activity
ESP47_17645	COG1250	3-hydroxyacyl-CoA dehydrogenase
ESP47_17650	COG0534	Mate efflux family protein
ESP47_17665	COG0789	Transcriptional regulator
ESP47_17670	COG0436	Aminotransferase
ESP47_17675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ESP47_17685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis