locus-tag	class	description
N4P52_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N4P52_00010	COG0592	DNA-directed DNA polymerase activity
N4P52_00015	COG2501	S4 domain
N4P52_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N4P52_00030	COG0187	DNA topoisomerase II activity
N4P52_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N4P52_00040	COG3437	response regulator, receiver
N4P52_00075	COG1982	Orn Lys Arg decarboxylase major
N4P52_00085	COG3870	Protein conserved in bacteria
N4P52_00090	COG1728	Protein conserved in bacteria
N4P52_00095	COG0470	DNA polymerase III
N4P52_00100	COG1774	PSP1 C-terminal conserved region
N4P52_00105	COG4467	Involved in initiation control of chromosome replication
N4P52_00110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
N4P52_00115	COG2827	Endonuclease containing a URI domain
N4P52_00120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N4P52_00135	COG0084	hydrolase, TatD family'
N4P52_00145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N4P52_00155	COG4466	Protein conserved in bacteria
N4P52_00165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N4P52_00170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N4P52_00175	COG0251	oxidation-reduction process
N4P52_00190	COG1136	(ABC) transporter
N4P52_00200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N4P52_00205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N4P52_00210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N4P52_00225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N4P52_00230	COG2002	toxin-antitoxin pair type II binding
N4P52_00235	COG2244	polysaccharide biosynthetic process
N4P52_00240	COG3956	TIGRFAM MazG family protein
N4P52_00245	COG3956	TIGRFAM MazG family protein
N4P52_00250	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N4P52_00270	COG1098	S1 RNA binding domain
N4P52_00280	COG2208	phosphoserine phosphatase activity
N4P52_00285	COG2304	oxidoreductase activity
N4P52_00290	COG0515	serine threonine protein kinase
N4P52_00295	COG0037	tRNA processing
N4P52_00300	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
N4P52_00305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N4P52_00310	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
N4P52_00315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N4P52_00320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N4P52_00325	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N4P52_00330	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N4P52_00335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N4P52_00415	COG0516	GMP reductase activity
N4P52_00415	COG0517	IMP dehydrogenase activity
N4P52_00430	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
N4P52_00435	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N4P52_00445	COG1428	Deoxynucleoside kinase
N4P52_00450	COG1428	Deoxynucleoside kinase
N4P52_00455	COG1388	LysM domain
N4P52_00455	COG3858	chitin binding
N4P52_00470	COG0590	tRNA wobble adenosine to inosine editing
N4P52_00480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N4P52_00485	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N4P52_00490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N4P52_00540	COG3880	PFAM UvrB UvrC protein
N4P52_00545	COG3869	Catalyzes the specific phosphorylation of arginine residues in
N4P52_00550	COG0542	response to heat
N4P52_00555	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N4P52_00560	COG4956	integral membrane protein (PIN domain superfamily)
N4P52_00570	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N4P52_00575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N4P52_00580	COG1045	serine acetyltransferase
N4P52_00585	COG0215	cysteine-tRNA ligase activity
N4P52_00595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N4P52_00600	COG3688	RNA-binding protein containing a PIN domain
N4P52_00610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N4P52_00615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N4P52_00620	COG0250	Participates in transcription elongation, termination and antitermination
N4P52_00625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N4P52_00630	COG0081	regulation of translation
N4P52_00635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N4P52_00640	COG0222	ribosome binding
N4P52_00645	COG2813	Specifically methylates the guanine in position
N4P52_00660	COG1358	cellular component organization or biogenesis
N4P52_00665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N4P52_00670	COG0049	tRNA binding
N4P52_00675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N4P52_00680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N4P52_00685	COG0051	transcription antitermination factor activity, RNA binding
N4P52_00695	COG0088	Forms part of the polypeptide exit tunnel
N4P52_00700	COG0089	rRNA binding
N4P52_00705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N4P52_00710	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N4P52_00720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N4P52_00725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N4P52_00730	COG0255	Belongs to the universal ribosomal protein uL29 family
N4P52_00735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N4P52_00740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N4P52_00745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N4P52_00755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N4P52_00760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N4P52_00765	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N4P52_00770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N4P52_00775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N4P52_00785	COG0200	Binds to the 23S rRNA
N4P52_00790	COG0201	protein transport
N4P52_00795	COG0563	adenylate kinase activity
N4P52_00800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N4P52_00805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N4P52_00810	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N4P52_00815	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N4P52_00820	COG0202	RNA polymerase activity
N4P52_00825	COG0203	ribosomal protein L17
N4P52_00830	COG1122	ATPase activity
N4P52_00835	COG1122	ATPase activity
N4P52_00840	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N4P52_00850	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N4P52_00855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N4P52_00875	COG2046	Belongs to the sulfate adenylyltransferase family
N4P52_00880	COG0529	Catalyzes the synthesis of activated sulfate
N4P52_00885	COG0833	amino acid
N4P52_00895	COG0860	N-Acetylmuramoyl-L-alanine amidase
N4P52_00900	COG0489	protein tyrosine kinase activity
N4P52_00910	COG2194	sulfuric ester hydrolase activity
N4P52_00920	COG0726	polysaccharide deacetylase
N4P52_00930	COG1271	oxidase subunit
N4P52_00935	COG1294	oxidase, subunit
N4P52_00940	COG4988	ABC transporter
N4P52_00945	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N4P52_00950	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_01030	COG1595	DNA-templated transcription, initiation
N4P52_01035	COG5662	AntiSigma factor
N4P52_01040	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
N4P52_01045	COG4856	YbbR-like protein
N4P52_01050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N4P52_01055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N4P52_01105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N4P52_01110	COG0840	transmembrane signaling receptor activity
N4P52_01125	COG1695	Transcriptional regulator
N4P52_01130	COG0840	transmembrane signaling receptor activity
N4P52_01135	COG0477	Major facilitator Superfamily
N4P52_01190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N4P52_01195	COG2814	Major facilitator Superfamily
N4P52_01205	COG0519	Catalyzes the synthesis of GMP from XMP
N4P52_01220	COG2814	Major facilitator Superfamily
N4P52_01220	COG0477	Major facilitator Superfamily
N4P52_01265	COG3425	synthase
N4P52_01275	COG0183	Belongs to the thiolase family
N4P52_01295	COG1125	glycine betaine transport
N4P52_01295	COG0517	IMP dehydrogenase activity
N4P52_01320	COG2190	(PTS) system
N4P52_01325	COG1263	PTS System
N4P52_01325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N4P52_01330	COG0366	Alpha amylase catalytic
N4P52_01335	COG2188	Transcriptional regulator
N4P52_01345	COG1070	Carbohydrate kinase
N4P52_01355	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
N4P52_01360	COG0716	FMN binding
N4P52_01375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N4P52_01385	COG2217	Heavy metal translocating P-type atpase
N4P52_01390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N4P52_01400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N4P52_01405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N4P52_01410	COG0463	Glycosyl transferase, family 2
N4P52_01440	COG2076	Multidrug Resistance protein
N4P52_01445	COG2076	Multidrug Resistance protein
N4P52_01455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N4P52_01460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N4P52_01465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N4P52_01470	COG1120	ATPase activity
N4P52_01495	COG0217	transcriptional regulatory protein
N4P52_01500	COG1366	Belongs to the anti-sigma-factor antagonist family
N4P52_01510	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_01520	COG1309	transcriptional regulator
N4P52_01540	COG1012	belongs to the aldehyde dehydrogenase family
N4P52_01545	COG5434	Belongs to the glycosyl hydrolase 28 family
N4P52_01555	COG0175	sulfate reduction
N4P52_01575	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N4P52_01580	COG0371	Dehydrogenase
N4P52_01585	COG0318	PFAM AMP-dependent synthetase and ligase
N4P52_01600	COG0697	spore germination
N4P52_01615	COG1230	cation diffusion facilitator family transporter
N4P52_01620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N4P52_01630	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N4P52_01645	COG0702	epimerase
N4P52_01655	COG3933	PFAM sigma-54 factor interaction domain-containing protein
N4P52_01655	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
N4P52_01665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4P52_01670	COG0765	amino acid transport
N4P52_01675	COG1126	abc transporter atp-binding protein
N4P52_01680	COG2222	sugar isomerase
N4P52_01685	COG2188	Transcriptional regulator
N4P52_01690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N4P52_01700	COG2188	Transcriptional regulator
N4P52_01710	COG2222	sugar isomerase
N4P52_01715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N4P52_01725	COG2186	Transcriptional regulator
N4P52_01730	COG2188	Transcriptional regulator
N4P52_01750	COG3716	PTS system mannose fructose sorbose family IID component
N4P52_01765	COG2188	Transcriptional regulator
N4P52_01775	COG2188	Transcriptional regulator
N4P52_01785	COG2188	Transcriptional regulator
N4P52_01800	COG0477	Major facilitator Superfamily
N4P52_01810	COG2222	sugar isomerase
N4P52_01815	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N4P52_01830	COG2848	UPF0210 protein
N4P52_01845	COG3328	transposase activity
N4P52_01855	COG0477	Major facilitator Superfamily
N4P52_01860	COG1609	Transcriptional regulator
N4P52_01875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N4P52_01890	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N4P52_01905	COG5577	PFAM Coat F domain
N4P52_01910	COG0667	Aldo Keto reductase
N4P52_01920	COG1113	amino acid transport
N4P52_01930	COG3104	oligopeptide transport
N4P52_01935	COG0833	amino acid
N4P52_01945	COG3842	ATPase activity
N4P52_01950	COG1176	ABC-type spermidine putrescine transport system, permease component I
N4P52_01975	COG0531	amino acid
N4P52_01980	COG1556	Lactate utilization protein
N4P52_01985	COG1139	Iron-sulfur cluster binding protein
N4P52_01990	COG0247	lactate metabolic process
N4P52_02000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N4P52_02005	COG1454	alcohol dehydrogenase
N4P52_02015	COG1953	Uracil, thiamine, allantoin
N4P52_02035	COG0531	amino acid
N4P52_02040	COG1979	alcohol dehydrogenase
N4P52_02045	COG0004	ammonium transporteR
N4P52_02050	COG3290	protein histidine kinase activity
N4P52_02055	COG4565	transcriptional regulatory protein
N4P52_02060	COG2851	Citrate transporter
N4P52_02065	COG0463	Glycosyl transferase, family 2
N4P52_02070	COG3973	AAA domain
N4P52_02095	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
N4P52_02100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N4P52_02105	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N4P52_02110	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N4P52_02115	COG1301	dicarboxylic acid transport
N4P52_02120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N4P52_02125	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
N4P52_02135	COG1902	pentaerythritol trinitrate reductase activity
N4P52_02155	COG0423	glycine-tRNA ligase activity
N4P52_02160	COG0531	amino acid
N4P52_02170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N4P52_02175	COG0628	permease
N4P52_02190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4P52_02195	COG0765	amino acid transport
N4P52_02200	COG0765	amino acid transport
N4P52_02215	COG1733	regulation of RNA biosynthetic process
N4P52_02225	COG0586	Pfam SNARE associated Golgi protein
N4P52_02230	COG0586	Pfam SNARE associated Golgi protein
N4P52_02245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N4P52_02245	COG0646	methionine synthase
N4P52_02250	COG0646	methionine synthase
N4P52_02250	COG1410	methionine synthase
N4P52_02280	COG3944	biosynthesis protein
N4P52_02285	COG0489	protein tyrosine kinase activity
N4P52_02290	COG4464	protein tyrosine phosphatase activity
N4P52_02295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N4P52_02300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N4P52_02305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N4P52_02310	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
N4P52_02320	COG0110	maltose O-acetyltransferase activity
N4P52_02340	COG1216	Glycosyl transferase, family 2
N4P52_02340	COG1442	glycosyl transferase family 8
N4P52_02345	COG1216	Glycosyl transferase, family 2
N4P52_02355	COG0662	Cupin 2, conserved barrel domain protein
N4P52_02355	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
N4P52_02360	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
N4P52_02380	COG1070	Carbohydrate kinase
N4P52_02415	COG1063	alcohol dehydrogenase
N4P52_02445	COG4193	domain, Protein
N4P52_02465	COG5504	Zn-dependent protease
N4P52_02470	COG2226	methyltransferase
N4P52_02485	COG0366	Alpha amylase catalytic
N4P52_02485	COG5263	repeat protein
N4P52_02510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4P52_02510	COG3711	transcriptional antiterminator
N4P52_02520	COG3730	PTS system glucitol sorbitol-specific
N4P52_02525	COG3732	PTS system glucitol sorbitol-specific
N4P52_02535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N4P52_02545	COG1396	sequence-specific DNA binding
N4P52_02560	COG1129	ABC transporter
N4P52_02565	COG1172	Belongs to the binding-protein-dependent transport system permease family
N4P52_02570	COG1879	ABC-type sugar transport system periplasmic component
N4P52_02575	COG1070	Carbohydrate kinase
N4P52_02585	COG0235	Class ii aldolase
N4P52_02605	COG0191	fructose-bisphosphate aldolase activity
N4P52_02610	COG3414	Phosphotransferase system galactitol-specific IIB component
N4P52_02615	COG3775	system Galactitol-specific IIC component
N4P52_02660	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N4P52_02670	COG0145	ligase activity
N4P52_02680	COG2315	Protein conserved in bacteria
N4P52_02690	COG0658	competence protein
N4P52_02690	COG2333	competence protein COMEC
N4P52_02735	COG0531	amino acid
N4P52_02745	COG1316	TRANSCRIPTIONal
N4P52_02755	COG4989	oxidoreductase activity
N4P52_02780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N4P52_02785	COG2130	NADP-dependent
N4P52_02795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4P52_02795	COG3711	transcriptional antiterminator
N4P52_02800	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N4P52_02805	COG1447	Phosphotransferase system cellobiose-specific component IIA
N4P52_02815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N4P52_02820	COG2211	Major facilitator Superfamily
N4P52_02820	COG2190	(PTS) system
N4P52_02830	COG1113	amino acid transport
N4P52_02860	COG2814	Major facilitator Superfamily
N4P52_02865	COG1609	Transcriptional regulator
N4P52_02880	COG1174	glycine betaine transport
N4P52_02885	COG1732	Glycine betaine
N4P52_02890	COG1174	glycine betaine transport
N4P52_02895	COG0517	IMP dehydrogenase activity
N4P52_02895	COG1125	glycine betaine transport
N4P52_02900	COG1510	regulation of RNA biosynthetic process
N4P52_02905	COG0110	maltose O-acetyltransferase activity
N4P52_02910	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_02925	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N4P52_02935	COG4297	protein containing double-stranded beta helix domain
N4P52_02945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N4P52_02955	COG2272	Belongs to the type-B carboxylesterase lipase family
N4P52_02960	COG2272	Belongs to the type-B carboxylesterase lipase family
N4P52_02965	COG0606	chelatase, subunit chli
N4P52_02980	COG0371	Dehydrogenase
N4P52_02985	COG2814	Major facilitator Superfamily
N4P52_02990	COG1070	Carbohydrate kinase
N4P52_02995	COG2115	Belongs to the xylose isomerase family
N4P52_03010	COG0157	Belongs to the NadC ModD family
N4P52_03015	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N4P52_03020	COG1104	cysteine desulfurase activity
N4P52_03035	COG2116	formate transmembrane transporter activity
N4P52_03040	COG0840	transmembrane signaling receptor activity
N4P52_03055	COG4720	Psort location CytoplasmicMembrane, score
N4P52_03065	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_03070	COG2610	gluconate transmembrane transporter activity
N4P52_03075	COG1012	belongs to the aldehyde dehydrogenase family
N4P52_03085	COG3290	protein histidine kinase activity
N4P52_03085	COG3829	transcription factor binding
N4P52_03090	COG1501	Belongs to the glycosyl hydrolase 31 family
N4P52_03100	COG1960	acyl-CoA dehydrogenase activity
N4P52_03105	COG0318	PFAM AMP-dependent synthetase and ligase
N4P52_03115	COG1309	transcriptional regulator
N4P52_03130	COG1363	Peptidase, m42
N4P52_03180	COG1620	l-lactate permease
N4P52_03185	COG2186	Transcriptional regulator
N4P52_03210	COG0473	3-isopropylmalate dehydrogenase activity
N4P52_03250	COG1447	Phosphotransferase system cellobiose-specific component IIA
N4P52_03265	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N4P52_03265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N4P52_03270	COG2723	6-phospho-beta-galactosidase activity
N4P52_03275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4P52_03275	COG3711	transcriptional antiterminator
N4P52_03280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
N4P52_03290	COG0626	cystathionine gamma-synthase activity
N4P52_03295	COG0626	cystathionine gamma-synthase activity
N4P52_03315	COG1653	transport
N4P52_03320	COG2207	Transcriptional regulator
N4P52_03345	COG0604	alcohol dehydrogenase
N4P52_03355	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N4P52_03360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N4P52_03380	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_03390	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
N4P52_03400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N4P52_03410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N4P52_03415	COG1316	TRANSCRIPTIONal
N4P52_03430	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
N4P52_03445	COG3584	3D domain protein
N4P52_03445	COG1388	LysM domain
N4P52_03455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N4P52_03465	COG0011	TIGRFAM Protein of
N4P52_03470	COG2706	6-phosphogluconolactonase activity
N4P52_03480	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
N4P52_03480	COG3933	PFAM sigma-54 factor interaction domain-containing protein
N4P52_03485	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N4P52_03485	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4P52_03495	COG3715	PTS system
N4P52_03500	COG3716	PTS system mannose fructose sorbose family IID component
N4P52_03515	COG2079	MmgE PrpD family protein
N4P52_03520	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N4P52_03530	COG0154	amidase activity
N4P52_03540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N4P52_03545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N4P52_03550	COG1116	anion transmembrane transporter activity
N4P52_03555	COG0083	homoserine kinase activity
N4P52_03560	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N4P52_03565	COG0460	homoserine dehydrogenase
N4P52_03570	COG0010	Belongs to the arginase family
N4P52_03580	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N4P52_03585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N4P52_03595	COG4145	pantothenate transmembrane transporter activity
N4P52_03610	COG1012	belongs to the aldehyde dehydrogenase family
N4P52_03610	COG1454	alcohol dehydrogenase
N4P52_03625	COG0791	NLP P60 protein
N4P52_03625	COG1388	LysM domain
N4P52_03630	COG0024	Methionine aminopeptidase
N4P52_03635	COG1268	BioY protein
N4P52_03645	COG0318	PFAM AMP-dependent synthetase and ligase
N4P52_03650	COG1960	acyl-CoA dehydrogenase activity
N4P52_03655	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_03660	COG2746	aminoglycoside 3-N-acetyltransferase activity
N4P52_03665	COG2244	polysaccharide biosynthetic process
N4P52_03670	COG0589	response to stress
N4P52_03685	COG0535	radical SAM domain protein
N4P52_03695	COG1063	alcohol dehydrogenase
N4P52_03705	COG1609	Transcriptional regulator
N4P52_03715	COG0561	phosphatase activity
N4P52_03750	COG0656	L-ascorbic acid biosynthetic process
N4P52_03755	COG0431	NADPH-dependent FMN reductase
N4P52_03760	COG0420	3'-5' exonuclease activity
N4P52_03765	COG4717	serine-type aminopeptidase activity
N4P52_03770	COG1250	3-hydroxyacyl-CoA dehydrogenase
N4P52_03775	COG0534	Mate efflux family protein
N4P52_03780	COG1664	Polymer-forming cytoskeletal
N4P52_03790	COG0789	Transcriptional regulator
N4P52_03795	COG0436	Aminotransferase
N4P52_03800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N4P52_03810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N4P52_03820	COG2226	methyltransferase
N4P52_03835	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
N4P52_03875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N4P52_03880	COG1113	amino acid transport
N4P52_03885	COG2814	Major facilitator Superfamily
N4P52_03900	COG2409	Drug exporters of the RND superfamily
N4P52_03900	COG1033	growth of symbiont in host cell
N4P52_03905	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
N4P52_03920	COG1960	acyl-CoA dehydrogenase activity
N4P52_03935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N4P52_03940	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
N4P52_03945	COG2017	converts alpha-aldose to the beta-anomer
N4P52_03950	COG1609	Transcriptional regulator
N4P52_03970	COG2996	Protein conserved in bacteria
N4P52_03975	COG0346	lactoylglutathione lyase activity
N4P52_03980	COG1482	cell wall glycoprotein biosynthetic process
N4P52_03990	COG0477	Major facilitator Superfamily
N4P52_03995	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N4P52_04005	COG2188	Transcriptional regulator
N4P52_04010	COG1388	LysM domain
N4P52_04010	COG0791	NLP P60 protein
N4P52_04020	COG0768	penicillin binding
N4P52_04025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N4P52_04030	COG1739	Uncharacterized protein family UPF0029
N4P52_04040	COG2197	response regulator
N4P52_04045	COG0531	amino acid
N4P52_04050	COG1307	EDD domain protein, DegV family
N4P52_04055	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
N4P52_04060	COG1040	competence protein
N4P52_04070	COG2747	anti-sigma28 factor FlgM
N4P52_04080	COG1256	bacterial-type flagellum assembly
N4P52_04080	COG4786	Flagellar basal body rod
N4P52_04085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N4P52_04095	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N4P52_04110	COG1067	ATP-dependent peptidase activity
N4P52_04120	COG2094	Belongs to the DNA glycosylase MPG family
N4P52_04130	COG1334	flagellar protein FlaG
N4P52_04135	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
N4P52_04140	COG1516	flagellar protein fliS
N4P52_04155	COG0405	Gamma-glutamyltransferase
N4P52_04160	COG0653	protein targeting
N4P52_04170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N4P52_04190	COG2884	Cell division ATP-binding protein ftsE
N4P52_04195	COG2177	Part of the ABC transporter FtsEX involved in
N4P52_04200	COG0739	heme binding
N4P52_04210	COG2873	o-acetylhomoserine
N4P52_04220	COG0460	homoserine dehydrogenase
N4P52_04225	COG0793	Belongs to the peptidase S41A family
N4P52_04225	COG3409	Peptidoglycan-binding domain 1 protein
N4P52_04235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N4P52_04240	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N4P52_04245	COG4605	iron ion homeostasis
N4P52_04250	COG4604	ABC transporter, ATP-binding protein
N4P52_04255	COG4607	ABC-type enterochelin transport system periplasmic component
N4P52_04270	COG0745	RESPONSE REGULATOR receiver
N4P52_04275	COG5002	protein histidine kinase activity
N4P52_04280	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
N4P52_04290	COG0573	inorganic phosphate transmembrane transporter activity
N4P52_04295	COG0581	inorganic phosphate transmembrane transporter activity
N4P52_04305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N4P52_04310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N4P52_04350	COG0556	nucleotide-excision repair
N4P52_04355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N4P52_04360	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N4P52_04370	COG0463	Glycosyl transferase, family 2
N4P52_04380	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
N4P52_04385	COG0463	Glycosyl transferase, family 2
N4P52_04385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
N4P52_04390	COG1682	transport, permease protein
N4P52_04395	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
N4P52_04400	COG3595	metallopeptidase activity
N4P52_04410	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
N4P52_04415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N4P52_04420	COG0546	phosphoglycolate phosphatase activity
N4P52_04425	COG0110	maltose O-acetyltransferase activity
N4P52_04430	COG0457	Tetratricopeptide repeat
N4P52_04435	COG0492	ferredoxin-NADP+ reductase activity
N4P52_04440	COG1051	belongs to the nudix hydrolase family
N4P52_04445	COG1660	Displays ATPase and GTPase activities
N4P52_04450	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N4P52_04455	COG1481	regulation of sporulation
N4P52_04460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4P52_04495	COG3842	ATPase activity
N4P52_04500	COG2508	Transcriptional regulator
N4P52_04510	COG0189	ligase activity
N4P52_04515	COG0189	ligase activity
N4P52_04525	COG4399	Belongs to the UPF0754 family
N4P52_04535	COG0561	phosphatase activity
N4P52_04540	COG1024	Enoyl-CoA hydratase
N4P52_04550	COG0861	Integral membrane protein TerC family
N4P52_04555	COG0701	Predicted permease
N4P52_04560	COG3689	TIGRFAM TIGR03943 family protein
N4P52_04565	COG0420	3'-5' exonuclease activity
N4P52_04570	COG4717	serine-type aminopeptidase activity
N4P52_04575	COG3481	metal-dependent phosphohydrolase, HD sub domain
N4P52_04585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N4P52_04600	COG1846	Transcriptional regulator
N4P52_04620	COG0537	adenosine 5'-monophosphoramidase activity
N4P52_04625	COG1131	(ABC) transporter
N4P52_04630	COG4473	ABC transporter
N4P52_04635	COG1473	amidohydrolase
N4P52_04640	COG3069	C4-dicarboxylate transmembrane transporter activity
N4P52_04645	COG2329	Antibiotic biosynthesis monooxygenase
N4P52_04650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N4P52_04655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N4P52_04660	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
N4P52_04665	COG1309	transcriptional regulator
N4P52_04670	COG1511	domain protein
N4P52_04675	COG2190	(PTS) system
N4P52_04675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N4P52_04675	COG2190	(PTS) system
N4P52_04675	COG1263	PTS System
N4P52_04675	COG1263	PTS System
N4P52_04675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N4P52_04680	COG1349	DNA-binding transcription factor activity
N4P52_04685	COG3254	rhamnose metabolic process
N4P52_04690	COG2814	Major facilitator Superfamily
N4P52_04695	COG0697	spore germination
N4P52_04700	COG1012	belongs to the aldehyde dehydrogenase family
N4P52_04705	COG1999	signal sequence binding
N4P52_04720	COG0095	Lipoate-protein ligase
N4P52_04725	COG0318	PFAM AMP-dependent synthetase and ligase
N4P52_04735	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
N4P52_04745	COG0501	Belongs to the peptidase M48B family
N4P52_04765	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
N4P52_04770	COG1074	ATP-dependent DNA helicase activity
N4P52_04805	COG2311	Membrane
N4P52_04810	COG0179	Fumarylacetoacetate (FAA) hydrolase
N4P52_04825	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_04840	COG1307	EDD domain protein, DegV family
N4P52_04855	COG0561	phosphatase activity
N4P52_04860	COG2151	metal-sulfur cluster biosynthetic enzyme
N4P52_04890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N4P52_04895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N4P52_04910	COG4608	Belongs to the ABC transporter superfamily
N4P52_04915	COG0601	transmembrane transport
N4P52_04925	COG0747	negative chemotaxis
N4P52_04940	COG0180	Tryptophanyl-tRNA synthetase
N4P52_04955	COG4166	transmembrane transport
N4P52_04960	COG0601	transmembrane transport
N4P52_04965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N4P52_04970	COG0444	Belongs to the ABC transporter superfamily
N4P52_04975	COG4608	Belongs to the ABC transporter superfamily
N4P52_04980	COG1393	Belongs to the ArsC family
N4P52_04985	COG4862	establishment of competence for transformation
N4P52_04990	COG4469	Competence protein
N4P52_04995	COG1164	Oligoendopeptidase f
N4P52_05005	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N4P52_05010	COG2346	COG2346, Truncated hemoglobins
N4P52_05015	COG0741	lytic transglycosylase activity
N4P52_05035	COG2357	RelA SpoT domain protein
N4P52_05045	COG0564	pseudouridine synthase activity
N4P52_05050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N4P52_05055	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N4P52_05090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N4P52_05115	COG2153	protein acetylation
N4P52_05125	COG2382	esterase
N4P52_05135	COG4193	domain, Protein
N4P52_05145	COG2188	Transcriptional regulator
N4P52_05170	COG1840	ABC-type Fe3 transport system, periplasmic component
N4P52_05175	COG3842	ATPase activity
N4P52_05185	COG1177	transmembrane transport
N4P52_05250	COG1940	carbohydrate kinase activity
N4P52_05260	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_05265	COG4152	abc transporter atp-binding protein
N4P52_05270	COG1668	transmembrane transport
N4P52_05280	COG3579	cysteine-type endopeptidase activity
N4P52_05300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N4P52_05305	COG2059	Chromate
N4P52_05310	COG2059	Chromate
N4P52_05315	COG1522	sequence-specific DNA binding
N4P52_05330	COG0154	amidase activity
N4P52_05350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N4P52_05355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N4P52_05420	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_05445	COG1959	2 iron, 2 sulfur cluster binding
N4P52_05455	COG0730	response to heat
N4P52_05460	COG0783	Belongs to the Dps family
N4P52_05465	COG0673	inositol 2-dehydrogenase activity
N4P52_05470	COG3852	Histidine kinase
N4P52_05475	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N4P52_05485	COG0861	Integral membrane protein TerC family
N4P52_05505	COG5002	protein histidine kinase activity
N4P52_05510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N4P52_05525	COG0542	response to heat
N4P52_05530	COG3949	Membrane
N4P52_05540	COG4873	Protein conserved in bacteria
N4P52_05550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4P52_05565	COG2084	Dehydrogenase
N4P52_05570	COG0436	Aminotransferase
N4P52_05575	COG0835	chemotaxis
N4P52_05575	COG0784	Response regulator, receiver
N4P52_05585	COG1033	growth of symbiont in host cell
N4P52_05585	COG2409	Drug exporters of the RND superfamily
N4P52_05600	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_05610	COG4703	Protein of unknown function (DUF1797)
N4P52_05615	COG0517	IMP dehydrogenase activity
N4P52_05620	COG0583	DNA-binding transcription factor activity
N4P52_05625	COG2171	N-acyltransferase activity
N4P52_05630	COG1473	amidohydrolase
N4P52_05640	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N4P52_05680	COG1982	Orn Lys Arg decarboxylase major
N4P52_05690	COG4476	Belongs to the UPF0223 family
N4P52_05705	COG0483	inositol monophosphate 1-phosphatase activity
N4P52_05715	COG1217	gtp-binding protein TYPA
N4P52_05725	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N4P52_05730	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
N4P52_05735	COG4838	Belongs to the UPF0358 family
N4P52_05740	COG0772	Belongs to the SEDS family
N4P52_05745	COG1612	heme a metabolic process
N4P52_05750	COG0109	protoheme IX farnesyltransferase activity
N4P52_05770	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
N4P52_05775	COG3336	cytochrome c oxidase
N4P52_05785	COG2340	Cysteine-rich secretory protein family
N4P52_05790	COG2050	protein possibly involved in aromatic compounds catabolism
N4P52_05810	COG3679	Belongs to the UPF0342 family
N4P52_05815	COG4471	UPF0298 protein
N4P52_05825	COG0742	ribosomal rna small subunit methyltransferase
N4P52_05830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N4P52_05835	COG3314	Sporulation integral membrane protein YlbJ
N4P52_05840	COG1752	Esterase of the alpha-beta hydrolase superfamily
N4P52_05845	COG3480	Lon protease (S16) C-terminal proteolytic domain
N4P52_05850	COG1323	Belongs to the UPF0348 family
N4P52_05855	COG1399	metal-binding, possibly nucleic acid-binding protein
N4P52_05860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N4P52_05870	COG0454	-acetyltransferase
N4P52_05875	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N4P52_05880	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
N4P52_05885	COG2001	Belongs to the MraZ family
N4P52_05890	COG0275	rRNA processing
N4P52_05895	COG4839	cell division protein FtsL
N4P52_05900	COG0768	penicillin binding
N4P52_05905	COG0768	penicillin binding
N4P52_05920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N4P52_05925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N4P52_05930	COG0772	Belongs to the SEDS family
N4P52_05935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N4P52_05940	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N4P52_05945	COG0849	cell division
N4P52_05950	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N4P52_05965	COG1191	sigma factor activity
N4P52_05970	COG1191	sigma factor activity
N4P52_05975	COG1873	PFAM PRC-barrel domain
N4P52_05980	COG3584	3D domain protein
N4P52_05980	COG1388	LysM domain
N4P52_05990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N4P52_05995	COG1799	cell septum assembly
N4P52_06000	COG0762	integral membrane protein
N4P52_06005	COG2302	S4 RNA-binding domain
N4P52_06010	COG3599	regulation of cell shape
N4P52_06025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N4P52_06030	COG0564	pseudouridine synthase activity
N4P52_06040	COG0540	Belongs to the ATCase OTCase family
N4P52_06045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N4P52_06065	COG0167	dihydroorotate dehydrogenase activity
N4P52_06070	COG0284	orotidine-5'-phosphate decarboxylase activity
N4P52_06075	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N4P52_06095	COG1917	Cupin 2, conserved barrel domain protein
N4P52_06095	COG2207	Transcriptional regulator
N4P52_06100	COG1070	Carbohydrate kinase
N4P52_06105	COG4806	L-rhamnose isomerase
N4P52_06110	COG0235	Class ii aldolase
N4P52_06115	COG1454	alcohol dehydrogenase
N4P52_06120	COG1803	Methylglyoxal synthase
N4P52_06125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N4P52_06130	COG0477	Major facilitator Superfamily
N4P52_06135	COG0477	Major facilitator Superfamily
N4P52_06140	COG1309	transcriptional regulator
N4P52_06155	COG0628	permease
N4P52_06160	COG0561	phosphatase activity
N4P52_06190	COG0720	synthase
N4P52_06200	COG0385	Bile acid
N4P52_06210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N4P52_06215	COG1561	YicC-like family, N-terminal region
N4P52_06220	COG2052	Domain of unknown function (DUF370)
N4P52_06225	COG0194	GDP metabolic process
N4P52_06230	COG1758	RNA polymerase activity
N4P52_06235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N4P52_06240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N4P52_06245	COG0242	peptide deformylase activity
N4P52_06250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N4P52_06255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N4P52_06255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N4P52_06260	COG0631	protein serine/threonine phosphatase activity
N4P52_06265	COG0515	serine threonine protein kinase
N4P52_06265	COG2815	serine threonine protein kinase
N4P52_06275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N4P52_06280	COG1564	THIamine pyrophosphokinase
N4P52_06290	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N4P52_06295	COG1302	Protein conserved in bacteria
N4P52_06300	COG1461	Dihydroxyacetone kinase
N4P52_06310	COG1760	l-serine dehydratase
N4P52_06315	COG1760	l-serine dehydratase
N4P52_06320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N4P52_06325	COG1349	DNA-binding transcription factor activity
N4P52_06330	COG0416	fatty acid biosynthetic process
N4P52_06335	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N4P52_06340	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_06350	COG0571	ribonuclease III activity
N4P52_06355	COG1196	nuclear chromosome segregation
N4P52_06360	COG0552	protein localization to endoplasmic reticulum
N4P52_06365	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
N4P52_06370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N4P52_06380	COG1837	Belongs to the UPF0109 family
N4P52_06390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N4P52_06395	COG0336	Belongs to the RNA methyltransferase TrmD family
N4P52_06410	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
N4P52_06425	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N4P52_06430	COG0045	succinate-CoA ligase (ADP-forming) activity
N4P52_06435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
N4P52_06440	COG0758	DNA mediated transformation
N4P52_06445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N4P52_06455	COG4974	Belongs to the 'phage' integrase family
N4P52_06460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
N4P52_06470	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
N4P52_06475	COG1815	bacterial-type flagellum-dependent cell motility
N4P52_06480	COG1558	bacterial-type flagellum-dependent cell motility
N4P52_06485	COG1677	Flagellar hook-basal body complex protein FliE
N4P52_06490	COG1766	The M ring may be actively involved in energy transduction
N4P52_06500	COG1317	bacterial-type flagellum organization
N4P52_06505	COG1157	protein secretion by the type III secretion system
N4P52_06510	COG2882	bacterial-type flagellum organization
N4P52_06525	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
N4P52_06535	COG4786	Flagellar basal body rod
N4P52_06545	COG1580	Controls the rotational direction of flagella during chemotaxis
N4P52_06550	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N4P52_06555	COG1776	CheC inhibitor of MCP methylation
N4P52_06555	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N4P52_06560	COG2201	protein-glutamate methylesterase activity
N4P52_06565	COG3190	flagellar
N4P52_06570	COG1338	Plays a role in the flagellum-specific transport system
N4P52_06575	COG1987	bacterial-type flagellum assembly
N4P52_06580	COG1684	flagellar biosynthetic protein fliR
N4P52_06585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N4P52_06590	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N4P52_06595	COG1419	protein localization to endoplasmic reticulum
N4P52_06600	COG0455	bacterial-type flagellum organization
N4P52_06605	COG2201	protein-glutamate methylesterase activity
N4P52_06610	COG0643	Histidine kinase
N4P52_06610	COG2198	Histidine kinase
N4P52_06615	COG0835	chemotaxis
N4P52_06620	COG1776	CheC inhibitor of MCP methylation
N4P52_06625	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
N4P52_06630	COG1191	sigma factor activity
N4P52_06640	COG0052	Belongs to the universal ribosomal protein uS2 family
N4P52_06645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N4P52_06650	COG0528	UMP kinase activity
N4P52_06655	COG0233	cytoplasmic translational termination
N4P52_06660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N4P52_06665	COG4589	Belongs to the CDS family
N4P52_06675	COG0750	zinc metalloprotease
N4P52_06680	COG0442	prolyl-tRNA aminoacylation
N4P52_06685	COG2176	DNA-directed DNA polymerase activity
N4P52_06690	COG0779	Required for maturation of 30S ribosomal subunits
N4P52_06695	COG0195	Participates in both transcription termination and antitermination
N4P52_06700	COG2740	Nucleic-acid-binding protein implicated in transcription termination
N4P52_06705	COG1358	cellular component organization or biogenesis
N4P52_06715	COG1550	Protein conserved in bacteria
N4P52_06720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N4P52_06725	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N4P52_06730	COG0196	riboflavin kinase activity
N4P52_06735	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N4P52_06740	COG1185	polyribonucleotide nucleotidyltransferase activity
N4P52_06745	COG0726	polysaccharide deacetylase
N4P52_06750	COG0612	Peptidase, M16
N4P52_06755	COG1873	PFAM PRC-barrel domain
N4P52_06760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N4P52_06765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N4P52_06770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N4P52_06775	COG0527	aspartate kinase activity
N4P52_06785	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N4P52_06790	COG0740	serine-type endopeptidase activity
N4P52_06800	COG1674	ftsk spoiiie
N4P52_06800	COG4980	gas vesicle protein
N4P52_06805	COG1744	ABC transporter substrate-binding protein PnrA-like
N4P52_06810	COG3845	ABC transporter
N4P52_06815	COG4603	Belongs to the binding-protein-dependent transport system permease family
N4P52_06820	COG1079	Belongs to the binding-protein-dependent transport system permease family
N4P52_06825	COG0612	Peptidase, M16
N4P52_06830	COG0612	Peptidase, M16
N4P52_06835	COG0300	oxidoreductase activity
N4P52_06850	COG1426	Protein conserved in bacteria
N4P52_06855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N4P52_06860	COG1058	Belongs to the CinA family
N4P52_06860	COG1546	Belongs to the CinA family
N4P52_06870	COG1418	mRNA catabolic process
N4P52_06875	COG1692	metallophosphoesterase
N4P52_06880	COG2359	stage V sporulation protein S
N4P52_06885	COG0826	peptidase U32
N4P52_06890	COG0826	peptidase U32
N4P52_06895	COG0531	amino acid
N4P52_06900	COG3829	transcription factor binding
N4P52_06905	COG1012	belongs to the aldehyde dehydrogenase family
N4P52_06915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N4P52_06920	COG4550	Control of competence regulator ComK, YlbF/YmcA
N4P52_06930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N4P52_06935	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N4P52_06965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N4P52_06975	COG0464	growth
N4P52_06980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N4P52_06985	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
N4P52_06990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N4P52_07010	COG1321	iron dependent repressor
N4P52_07015	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N4P52_07025	COG1418	mRNA catabolic process
N4P52_07030	COG0488	(ABC) transporter
N4P52_07035	COG1413	lyase activity
N4P52_07050	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
N4P52_07055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N4P52_07060	COG1272	protein, Hemolysin III
N4P52_07065	COG2755	lipolytic protein G-D-S-L family
N4P52_07075	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
N4P52_07075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N4P52_07080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N4P52_07085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N4P52_07095	COG0840	transmembrane signaling receptor activity
N4P52_07100	COG4479	Belongs to the UPF0346 family
N4P52_07120	COG1876	peptidase activity
N4P52_07125	COG0793	Belongs to the peptidase S41A family
N4P52_07125	COG3409	Peptidoglycan-binding domain 1 protein
N4P52_07130	COG1846	Transcriptional regulator
N4P52_07135	COG2340	Cysteine-rich secretory protein family
N4P52_07140	COG0534	Mate efflux family protein
N4P52_07150	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N4P52_07155	COG1793	dna ligase
N4P52_07155	COG3285	dna ligase
N4P52_07160	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
N4P52_07165	COG0671	phosphoesterase, PA-phosphatase related
N4P52_07170	COG1368	sulfuric ester hydrolase activity
N4P52_07185	COG1331	Highly conserved protein containing a thioredoxin domain
N4P52_07190	COG2814	Major facilitator Superfamily
N4P52_07195	COG0745	RESPONSE REGULATOR receiver
N4P52_07200	COG5002	protein histidine kinase activity
N4P52_07210	COG0567	Dehydrogenase, E1 component
N4P52_07215	COG0508	dehydrogenase complex catalyzes the overall conversion of
N4P52_07220	COG1012	belongs to the aldehyde dehydrogenase family
N4P52_07235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N4P52_07245	COG1054	Belongs to the UPF0176 family
N4P52_07250	COG2135	peptidase activity
N4P52_07260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N4P52_07265	COG0516	GMP reductase activity
N4P52_07265	COG0517	IMP dehydrogenase activity
N4P52_07270	COG0723	plastoquinol--plastocyanin reductase activity
N4P52_07270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N4P52_07275	COG3584	3D domain protein
N4P52_07275	COG1388	LysM domain
N4P52_07280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N4P52_07285	COG1113	amino acid transport
N4P52_07290	COG1280	lysine exporter protein (LysE YggA)
N4P52_07295	COG0598	Magnesium transport protein CorA
N4P52_07305	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
N4P52_07310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N4P52_07315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N4P52_07320	COG0131	Imidazoleglycerol-phosphate dehydratase
N4P52_07325	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N4P52_07335	COG0107	imidazoleglycerol-phosphate synthase activity
N4P52_07340	COG0140	phosphoribosyl-ATP diphosphatase activity
N4P52_07340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N4P52_07350	COG2391	methyltransferase activity
N4P52_07355	COG2962	Rard protein
N4P52_07360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N4P52_07365	COG0569	domain protein
N4P52_07385	COG2807	transmembrane transport
N4P52_07390	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N4P52_07400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N4P52_07410	COG1278	Cold shock
N4P52_07415	COG0302	gtp cyclohydrolase
N4P52_07420	COG0492	ferredoxin-NADP+ reductase activity
N4P52_07435	COG0577	efflux transmembrane transporter activity
N4P52_07440	COG1136	(ABC) transporter
N4P52_07445	COG0642	Histidine kinase
N4P52_07450	COG0745	RESPONSE REGULATOR receiver
N4P52_07465	COG0640	Transcriptional regulator
N4P52_07470	COG2814	Major facilitator Superfamily
N4P52_07475	COG5039	Polysaccharide pyruvyl transferase
N4P52_07485	COG1113	amino acid transport
N4P52_07500	COG0477	Major facilitator Superfamily
N4P52_07510	COG1132	(ABC) transporter
N4P52_07515	COG1132	(ABC) transporter
N4P52_07525	COG1380	Effector of murein hydrolase LrgA
N4P52_07530	COG1346	cytolysis
N4P52_07535	COG0318	PFAM AMP-dependent synthetase and ligase
N4P52_07560	COG2309	aminopeptidase activity
N4P52_07570	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N4P52_07590	COG0824	Thioesterase
N4P52_07600	COG4841	protein insertion into membrane
N4P52_07605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N4P52_07610	COG1832	CoA-binding protein
N4P52_07615	COG0187	DNA topoisomerase II activity
N4P52_07620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N4P52_07635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
N4P52_07640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N4P52_07640	COG0574	Belongs to the PEP-utilizing enzyme family
N4P52_07665	COG2070	2-Nitropropane dioxygenase
N4P52_07675	COG0681	Belongs to the peptidase S26 family
N4P52_07680	COG0473	3-isopropylmalate dehydrogenase activity
N4P52_07685	COG2226	methyltransferase
N4P52_07710	COG0456	acetyltransferase
N4P52_07715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N4P52_07720	COG0456	acetyltransferase
N4P52_07730	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N4P52_07735	COG0351	phosphomethylpyrimidine kinase
N4P52_07740	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_07745	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
N4P52_07750	COG0351	phosphomethylpyrimidine kinase
N4P52_07755	COG0352	thiamine-phosphate diphosphorylase activity
N4P52_07760	COG2258	MOSC domain
N4P52_07795	COG1309	transcriptional regulator
N4P52_07800	COG2814	Major facilitator Superfamily
N4P52_07805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N4P52_07810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N4P52_07820	COG1809	phosphosulfolactate synthase activity
N4P52_07825	COG2045	Belongs to the ComB family
N4P52_07830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N4P52_07835	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N4P52_07845	COG0789	Transcriptional regulator
N4P52_07850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N4P52_07855	COG0697	spore germination
N4P52_07860	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N4P52_07865	COG0022	dehydrogenase e1 component
N4P52_07870	COG0508	dehydrogenase complex catalyzes the overall conversion of
N4P52_07875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N4P52_07880	COG3284	Transcriptional regulator
N4P52_07885	COG3264	Mechanosensitive ion channel
N4P52_07885	COG1511	domain protein
N4P52_07900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N4P52_07905	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
N4P52_07920	COG0183	Belongs to the thiolase family
N4P52_07925	COG0318	PFAM AMP-dependent synthetase and ligase
N4P52_07935	COG0561	phosphatase activity
N4P52_07940	COG2322	membrane
N4P52_07955	COG0039	L-malate dehydrogenase activity
N4P52_07960	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_07965	COG2223	nitrite transmembrane transporter activity
N4P52_07970	COG3773	Cell wall hydrolase
N4P52_07975	COG0708	Exodeoxyribonuclease III
N4P52_07985	COG0297	glycogen (starch) synthase activity
N4P52_07990	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N4P52_07995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N4P52_08000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N4P52_08020	COG1247	-acetyltransferase
N4P52_08025	COG0494	nUDIX hydrolase
N4P52_08030	COG1914	H( )-stimulated, divalent metal cation uptake system
N4P52_08035	COG0783	Belongs to the Dps family
N4P52_08045	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
N4P52_08050	COG1131	(ABC) transporter
N4P52_08075	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N4P52_08085	COG2030	dehydratase
N4P52_08090	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_08105	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
N4P52_08110	COG0709	Synthesizes selenophosphate from selenide and ATP
N4P52_08125	COG0701	Predicted permease
N4P52_08130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N4P52_08135	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N4P52_08145	COG1252	NADH dehydrogenase
N4P52_08150	COG2404	hydrolase activity, acting on ester bonds
N4P52_08160	COG4990	cell redox homeostasis
N4P52_08165	COG0789	Transcriptional regulator
N4P52_08190	COG0436	Aminotransferase
N4P52_08195	COG0165	Argininosuccinate lyase
N4P52_08200	COG0137	argininosuccinate synthase activity
N4P52_08205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N4P52_08210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N4P52_08215	COG0505	Belongs to the CarA family
N4P52_08220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N4P52_08225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N4P52_08230	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N4P52_08235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N4P52_08250	COG3546	catalase activity
N4P52_08270	COG1619	proteins homologs of microcin C7 resistance protein MccF
N4P52_08275	COG2027	D-alanyl-D-alanine carboxypeptidase
N4P52_08280	COG0204	Acyl-transferase
N4P52_08290	COG4846	Membrane protein involved in cytochrome C biogenesis
N4P52_08295	COG2201	protein-glutamate methylesterase activity
N4P52_08300	COG0785	Cytochrome C biogenesis protein
N4P52_08305	COG3763	UPF0154 protein
N4P52_08320	COG4224	UPF0291 protein
N4P52_08325	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N4P52_08335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N4P52_08355	COG0174	glutamine synthetase
N4P52_08360	COG0789	Transcriptional regulator
N4P52_08365	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
N4P52_08380	COG2233	PERMEase
N4P52_08390	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
N4P52_08395	COG0116	Belongs to the methyltransferase superfamily
N4P52_08410	COG4474	Belongs to the UPF0398 family
N4P52_08420	COG3359	exonuclease
N4P52_08425	COG1111	helicase
N4P52_08425	COG1205	dead DEAH box helicase
N4P52_08430	COG0071	Belongs to the small heat shock protein (HSP20) family
N4P52_08455	COG3331	DNA recombination
N4P52_08460	COG4499	WXG100 protein secretion system (Wss), protein YukC
N4P52_08460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N4P52_08465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N4P52_08470	COG3935	DnaD domain protein
N4P52_08475	COG0017	Asparaginyl-tRNA synthetase
N4P52_08490	COG1199	ATP-dependent helicase activity
N4P52_08490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N4P52_08495	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
N4P52_08500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N4P52_08520	COG0438	transferase activity, transferring glycosyl groups
N4P52_08525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N4P52_08530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N4P52_08535	COG1694	Mazg nucleotide pyrophosphohydrolase
N4P52_08540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N4P52_08550	COG2738	Putative neutral zinc metallopeptidase
N4P52_08560	COG4347	Protein of unknown function (DUF1405)
N4P52_08570	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N4P52_08585	COG5582	Belongs to the UPF0302 family
N4P52_08590	COG0457	Tetratricopeptide repeat
N4P52_08595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N4P52_08600	COG0287	Prephenate dehydrogenase
N4P52_08605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N4P52_08610	COG4401	Chorismate mutase type I
N4P52_08615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N4P52_08620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N4P52_08625	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N4P52_08630	COG0105	UTP biosynthetic process
N4P52_08635	COG0142	geranyltranstransferase activity
N4P52_08640	COG2226	methyltransferase
N4P52_08645	COG0142	geranyltranstransferase activity
N4P52_08655	COG0776	regulation of translation
N4P52_08660	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
N4P52_08680	COG1160	GTP binding
N4P52_08695	COG0539	negative regulation of cytoplasmic translation
N4P52_08700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N4P52_08705	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
N4P52_08710	COG2959	enzyme of heme biosynthesis
N4P52_08715	COG3409	Peptidoglycan-binding domain 1 protein
N4P52_08715	COG3773	Cell wall hydrolase
N4P52_08720	COG2339	peptidase activity
N4P52_08725	COG0492	ferredoxin-NADP+ reductase activity
N4P52_08730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N4P52_08740	COG1408	metallophosphoesterase
N4P52_08755	COG3546	catalase activity
N4P52_08770	COG1266	CAAX protease self-immunity
N4P52_08775	COG0514	ATP-dependent DNA helicase (RecQ)
N4P52_08785	COG1141	Ferredoxin
N4P52_08790	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
N4P52_08795	COG0739	heme binding
N4P52_08795	COG0741	lytic transglycosylase activity
N4P52_08795	COG1196	nuclear chromosome segregation
N4P52_08800	COG5002	protein histidine kinase activity
N4P52_08805	COG0745	RESPONSE REGULATOR receiver
N4P52_08810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N4P52_08815	COG1333	cytochrome c biogenesis protein
N4P52_08820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N4P52_08825	COG1187	pseudouridine synthase activity
N4P52_08830	COG0700	Nucleoside recognition
N4P52_08835	COG2715	membrane protein required for spore maturation
N4P52_08840	COG1686	Belongs to the peptidase S11 family
N4P52_08845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N4P52_08870	COG0697	spore germination
N4P52_08890	COG1191	sigma factor activity
N4P52_08905	COG1686	Belongs to the peptidase S11 family
N4P52_08910	COG4974	Belongs to the 'phage' integrase family
N4P52_08920	COG0735	belongs to the Fur family
N4P52_08925	COG1300	Membrane
N4P52_08930	COG1379	DNA repair
N4P52_08945	COG0667	Aldo Keto reductase
N4P52_08955	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
N4P52_08960	COG3853	Toxic anion resistance protein (TelA)
N4P52_08965	COG1073	alpha beta
N4P52_08970	COG1388	LysM domain
N4P52_08970	COG3858	chitin binding
N4P52_08980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N4P52_08985	COG0300	oxidoreductase activity
N4P52_08990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N4P52_09000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N4P52_09005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N4P52_09015	COG2195	Cleaves the N-terminal amino acid of tripeptides
N4P52_09025	COG1376	ErfK ybiS ycfS ynhG family protein
N4P52_09035	COG1105	Belongs to the carbohydrate kinase PfkB family
N4P52_09040	COG0508	dehydrogenase complex catalyzes the overall conversion of
N4P52_09045	COG0022	dehydrogenase e1 component
N4P52_09050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N4P52_09055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N4P52_09065	COG3290	protein histidine kinase activity
N4P52_09065	COG3829	transcription factor binding
N4P52_09075	COG0584	glycerophosphoryl diester phosphodiesterase
N4P52_09080	COG0745	RESPONSE REGULATOR receiver
N4P52_09085	COG0750	zinc metalloprotease
N4P52_09090	COG0497	DNA recombination
N4P52_09100	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
N4P52_09105	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N4P52_09120	COG1570	exodeoxyribonuclease VII activity
N4P52_09135	COG1302	Protein conserved in bacteria
N4P52_09140	COG0439	Biotin carboxylase
N4P52_09145	COG0511	ligase activity, forming carbon-carbon bonds
N4P52_09185	COG3854	ATPases associated with a variety of cellular activities
N4P52_09190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N4P52_09195	COG0006	proline dipeptidase activity
N4P52_09200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N4P52_09210	COG3872	metal-dependent enzyme
N4P52_09220	COG1752	Esterase of the alpha-beta hydrolase superfamily
N4P52_09230	COG3327	negative regulation of DNA-templated transcription, initiation
N4P52_09235	COG0183	Belongs to the thiolase family
N4P52_09240	COG1250	3-hydroxyacyl-CoA dehydrogenase
N4P52_09245	COG1012	belongs to the aldehyde dehydrogenase family
N4P52_09250	COG1024	Enoyl-CoA hydratase
N4P52_09260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N4P52_09265	COG0095	Lipoate-protein ligase
N4P52_09270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N4P52_09275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N4P52_09285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N4P52_09290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N4P52_09305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N4P52_09330	COG4537	Required for transformation and DNA binding
N4P52_09335	COG1459	type II secretion system
N4P52_09340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N4P52_09355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N4P52_09365	COG1940	carbohydrate kinase activity
N4P52_09370	COG4483	Protein conserved in bacteria
N4P52_09375	COG0457	Tetratricopeptide repeat
N4P52_09375	COG0705	Rhomboid family
N4P52_09385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N4P52_09395	COG0768	penicillin binding
N4P52_09400	COG0477	Major facilitator Superfamily
N4P52_09405	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N4P52_09415	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N4P52_09420	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
N4P52_09425	COG0735	belongs to the Fur family
N4P52_09430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N4P52_09435	COG1121	(ABC) transporter
N4P52_09445	COG3883	PFAM NLP P60 protein
N4P52_09445	COG0791	NLP P60 protein
N4P52_09450	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
N4P52_09455	COG0513	Belongs to the DEAD box helicase family
N4P52_09465	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N4P52_09470	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N4P52_09475	COG2384	SAM-dependent methyltransferase
N4P52_09480	COG2010	Cytochrome c
N4P52_09490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N4P52_09495	COG0358	DNA primase activity
N4P52_09505	COG0517	IMP dehydrogenase activity
N4P52_09510	COG1381	Involved in DNA repair and RecF pathway recombination
N4P52_09525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N4P52_09530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N4P52_09535	COG1480	7TM receptor with intracellular HD hydrolase
N4P52_09540	COG1702	phosphate starvation-inducible protein PhoH
N4P52_09555	COG1610	YqeY-like protein
N4P52_09570	COG1283	sodium-dependent phosphate transmembrane transporter activity
N4P52_09575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N4P52_09580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N4P52_09585	COG2264	protein methyltransferase activity
N4P52_09595	COG0443	Heat shock 70 kDa protein
N4P52_09600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N4P52_09610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N4P52_09615	COG0481	GTPase activity
N4P52_09620	COG0860	N-Acetylmuramoyl-L-alanine amidase
N4P52_09625	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
N4P52_09630	COG0268	Binds directly to 16S ribosomal RNA
N4P52_09635	COG1466	dna polymerase III delta subunit
N4P52_09645	COG0658	competence protein
N4P52_09645	COG2333	competence protein COMEC
N4P52_09650	COG2131	deaminase
N4P52_09655	COG1555	photosystem II stabilization
N4P52_09655	COG1596	polysaccharide export
N4P52_09660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N4P52_09665	COG2226	methyltransferase
N4P52_09670	COG0799	negative regulation of ribosome biogenesis
N4P52_09675	COG1713	HD superfamily hydrolase involved in NAD metabolism
N4P52_09680	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N4P52_09685	COG1534	Rna-binding protein
N4P52_09695	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
N4P52_09700	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
N4P52_09705	COG0247	lactate metabolic process
N4P52_09710	COG0277	FAD linked oxidase domain protein
N4P52_09715	COG3835	regulator
N4P52_09720	COG2132	Multicopper oxidase
N4P52_09725	COG0071	Belongs to the small heat shock protein (HSP20) family
N4P52_09730	COG2210	Belongs to the sulfur carrier protein TusA family
N4P52_09745	COG0446	pyridine nucleotide-disulphide oxidoreductase
N4P52_09755	COG2132	Multicopper oxidase
N4P52_09760	COG0071	Belongs to the small heat shock protein (HSP20) family
N4P52_09770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N4P52_09780	COG1704	LemA family
N4P52_09790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N4P52_09810	COG1183	phosphatidylcholine synthase activity
N4P52_09825	COG3634	alkyl hydroperoxide reductase activity
N4P52_09830	COG0450	alkyl hydroperoxide reductase
N4P52_09860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N4P52_09865	COG0572	uridine kinase
N4P52_09870	COG4122	O-methyltransferase activity
N4P52_09875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N4P52_09880	COG3906	Belongs to the UPF0473 family
N4P52_09885	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N4P52_09890	COG4472	Bacterial protein of unknown function (DUF965)
N4P52_09895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N4P52_09900	COG0628	permease
N4P52_09930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N4P52_09940	COG0482	sulfurtransferase activity
N4P52_09945	COG1104	cysteine desulfurase activity
N4P52_09950	COG1959	2 iron, 2 sulfur cluster binding
N4P52_09965	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_09970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N4P52_09975	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N4P52_09980	COG0385	Bile acid
N4P52_09990	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N4P52_09995	COG0124	histidyl-tRNA synthetase
N4P52_10005	COG3103	Sh3 type 3 domain protein
N4P52_10005	COG4991	sh3 domain protein
N4P52_10005	COG0860	N-Acetylmuramoyl-L-alanine amidase
N4P52_10010	COG2814	Major facilitator Superfamily
N4P52_10015	COG1566	PFAM secretion protein HlyD family protein
N4P52_10020	COG1846	Transcriptional regulator
N4P52_10025	COG1490	D-aminoacyl-tRNA deacylase activity
N4P52_10030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N4P52_10035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N4P52_10040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N4P52_10040	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
N4P52_10045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N4P52_10045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N4P52_10055	COG2244	polysaccharide biosynthetic process
N4P52_10060	COG2323	membrane
N4P52_10070	COG1862	Preprotein translocase
N4P52_10075	COG0343	queuine tRNA-ribosyltransferase activity
N4P52_10080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N4P52_10095	COG0632	four-way junction helicase activity
N4P52_10100	COG0217	transcriptional regulatory protein
N4P52_10115	COG1827	regulation of RNA biosynthetic process
N4P52_10120	COG0077	Prephenate dehydratase
N4P52_10125	COG4492	Belongs to the UPF0735 family
N4P52_10130	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N4P52_10135	COG3290	protein histidine kinase activity
N4P52_10140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N4P52_10145	COG2868	ribosomal protein
N4P52_10150	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N4P52_10155	COG1530	ribonuclease E activity
N4P52_10160	COG1994	Peptidase M50
N4P52_10170	COG2894	cell division
N4P52_10175	COG0850	regulation of cytokinetic process
N4P52_10185	COG1792	Involved in formation and maintenance of cell shape
N4P52_10190	COG1077	Cell shape determining protein MreB Mrl
N4P52_10195	COG2003	Belongs to the UPF0758 family
N4P52_10205	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
N4P52_10230	COG1459	type II secretion system
N4P52_10240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N4P52_10275	COG0285	dihydrofolate synthase activity
N4P52_10290	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N4P52_10295	COG1388	LysM domain
N4P52_10295	COG1388	LysM domain
N4P52_10300	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N4P52_10305	COG0113	porphobilinogen synthase activity
N4P52_10315	COG0181	hydroxymethylbilane synthase activity
N4P52_10320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N4P52_10335	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N4P52_10340	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N4P52_10345	COG0470	DNA polymerase III
N4P52_10345	COG1067	ATP-dependent peptidase activity
N4P52_10355	COG0544	peptidyl-prolyl cis-trans isomerase activity
N4P52_10360	COG1477	protein flavinylation
N4P52_10360	COG0457	Tetratricopeptide repeat
N4P52_10380	COG0622	Phosphoesterase
N4P52_10385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N4P52_10390	COG5401	PFAM Sporulation and spore germination
N4P52_10400	COG5577	PFAM Coat F domain
N4P52_10405	COG1063	alcohol dehydrogenase
N4P52_10410	COG5577	PFAM Coat F domain
N4P52_10425	COG1846	Transcriptional regulator
N4P52_10450	COG2197	response regulator
N4P52_10455	COG0824	Thioesterase
N4P52_10460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N4P52_10465	COG1053	succinate dehydrogenase
N4P52_10470	COG2009	succinate dehydrogenase
N4P52_10475	COG1719	4-vinyl reductase, 4VR
N4P52_10485	COG0322	excinuclease ABC activity
N4P52_10490	COG3118	belongs to the thioredoxin family
N4P52_10495	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
N4P52_10500	COG2086	electron transfer activity
N4P52_10505	COG1024	Enoyl-CoA hydratase
N4P52_10510	COG1309	transcriptional regulator
N4P52_10515	COG0318	PFAM AMP-dependent synthetase and ligase
N4P52_10520	COG1193	negative regulation of DNA recombination
N4P52_10525	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
N4P52_10525	COG1796	DNA polymerase
N4P52_10530	COG1286	toxin biosynthetic process
N4P52_10535	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
N4P52_10545	COG0072	phenylalanine-tRNA ligase activity
N4P52_10545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N4P52_10550	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N4P52_10555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N4P52_10590	COG2329	Antibiotic biosynthesis monooxygenase
N4P52_10600	COG1695	Transcriptional regulator
N4P52_10620	COG0431	NADPH-dependent FMN reductase
N4P52_10655	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N4P52_10665	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N4P52_10675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N4P52_10685	COG1484	DNA-dependent DNA replication
N4P52_10690	COG3611	Membrane attachment protein
N4P52_10695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N4P52_10700	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N4P52_10705	COG0237	dephospho-CoA kinase activity
N4P52_10710	COG1971	Probably functions as a manganese efflux pump
N4P52_10715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N4P52_10720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N4P52_10720	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N4P52_10725	COG0039	L-malate dehydrogenase activity
N4P52_10730	COG0538	isocitrate dehydrogenase activity
N4P52_10735	COG0372	Belongs to the citrate synthase family
N4P52_10740	COG2707	UPF0756 membrane protein
N4P52_10745	COG0628	permease
N4P52_10755	COG0205	6-phosphofructokinase activity
N4P52_10760	COG0825	malonyl-CoA metabolic process
N4P52_10765	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N4P52_10770	COG0281	malic enzyme
N4P52_10775	COG0587	DNA-directed DNA polymerase activity
N4P52_10790	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
N4P52_10800	COG4109	DRTGG domain
N4P52_10805	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N4P52_10810	COG0006	proline dipeptidase activity
N4P52_10820	COG0589	response to stress
N4P52_10830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N4P52_10835	COG0827	DNA restriction-modification system
N4P52_10840	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
N4P52_10845	COG3874	Sporulation protein YtfJ
N4P52_10855	COG1714	RDD family
N4P52_10860	COG0616	signal peptide processing
N4P52_10865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N4P52_10875	COG0301	tRNA thio-modification
N4P52_10880	COG1104	cysteine desulfurase activity
N4P52_10885	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
N4P52_10895	COG1309	transcriptional regulator
N4P52_10900	COG1956	GAF domain-containing protein
N4P52_10905	COG2199	diguanylate cyclase activity
N4P52_10905	COG2203	Gaf domain
N4P52_10910	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N4P52_10915	COG0506	proline dehydrogenase activity
N4P52_10920	COG1012	belongs to the aldehyde dehydrogenase family
N4P52_10925	COG3290	protein histidine kinase activity
N4P52_10925	COG3829	transcription factor binding
N4P52_10935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N4P52_10950	COG3383	formate dehydrogenase (NAD+) activity
N4P52_10955	COG2427	Protein of unknown function (DUF1641)
N4P52_10960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N4P52_10965	COG0315	cyclic pyranopterin monophosphate synthase activity
N4P52_10970	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N4P52_10975	COG0314	molybdopterin synthase activity
N4P52_10980	COG1763	Mo-molybdopterin cofactor biosynthetic process
N4P52_10985	COG0303	'Molybdopterin
N4P52_11000	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N4P52_11005	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N4P52_11010	COG4149	molybdate abc transporter
N4P52_11020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N4P52_11025	COG0454	-acetyltransferase
N4P52_11030	COG0517	IMP dehydrogenase activity
N4P52_11035	COG0123	including yeast histone deacetylase and acetoin utilization protein
N4P52_11045	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
N4P52_11045	COG1605	Chorismate mutase
N4P52_11050	COG4980	gas vesicle protein
N4P52_11060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N4P52_11065	COG1674	ftsk spoiiie
N4P52_11075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N4P52_11080	COG4848	Belongs to the UPF0354 family
N4P52_11085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N4P52_11090	COG2208	phosphoserine phosphatase activity
N4P52_11095	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N4P52_11100	COG5002	protein histidine kinase activity
N4P52_11100	COG0784	Response regulator, receiver
N4P52_11125	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
N4P52_11130	COG1363	Peptidase, m42
N4P52_11135	COG5584	Small secreted protein
N4P52_11140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N4P52_11145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N4P52_11155	COG0510	thiamine kinase activity
N4P52_11180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N4P52_11185	COG1349	DNA-binding transcription factor activity
N4P52_11190	COG2244	polysaccharide biosynthetic process
N4P52_11210	COG0495	leucyl-tRNA aminoacylation
N4P52_11215	COG2814	Major facilitator Superfamily
N4P52_11225	COG0275	rRNA processing
N4P52_11235	COG2267	carboxylic ester hydrolase activity
N4P52_11240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
N4P52_11245	COG0367	asparagine synthase
N4P52_11250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N4P52_11265	COG1506	peptidase
N4P52_11290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N4P52_11295	COG1116	anion transmembrane transporter activity
N4P52_11300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N4P52_11315	COG0783	Belongs to the Dps family
N4P52_11320	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N4P52_11330	COG0803	Belongs to the bacterial solute-binding protein 9 family
N4P52_11340	COG4948	Mandelate Racemase Muconate Lactonizing
N4P52_11345	COG0318	PFAM AMP-dependent synthetase and ligase
N4P52_11350	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
N4P52_11355	COG0596	Alpha beta hydrolase
N4P52_11360	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
N4P52_11365	COG1169	isochorismate synthase
N4P52_11370	COG1575	Belongs to the MenA family. Type 1 subfamily
N4P52_11495	COG0577	efflux transmembrane transporter activity
N4P52_11495	COG1136	(ABC) transporter
N4P52_11515	COG1285	pathogenesis
N4P52_11530	COG2217	Heavy metal translocating P-type atpase
N4P52_11535	COG2608	mercury ion transmembrane transporter activity
N4P52_11550	COG1522	sequence-specific DNA binding
N4P52_11570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N4P52_11590	COG0726	polysaccharide deacetylase
N4P52_11615	COG0038	chloride channel
N4P52_11625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N4P52_11625	COG0425	Belongs to the sulfur carrier protein TusA family
N4P52_11630	COG1937	Protein conserved in bacteria
N4P52_11640	COG1525	nuclease
N4P52_11645	COG2190	(PTS) system
N4P52_11655	COG2160	L-arabinose isomerase activity
N4P52_11660	COG4214	carbohydrate transport
N4P52_11670	COG4213	ABC transporter substrate-binding protein
N4P52_11675	COG1609	Transcriptional regulator
N4P52_11680	COG2160	L-arabinose isomerase activity
N4P52_11685	COG0235	Class ii aldolase
N4P52_11700	COG1609	Transcriptional regulator
N4P52_11710	COG0840	transmembrane signaling receptor activity
N4P52_11725	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_11730	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
N4P52_11745	COG1012	belongs to the aldehyde dehydrogenase family
N4P52_11765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N4P52_11775	COG2155	Conserved Protein
N4P52_11790	COG1098	S1 RNA binding domain
N4P52_11805	COG0656	L-ascorbic acid biosynthetic process
N4P52_11825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N4P52_11835	COG2814	Major facilitator Superfamily
N4P52_11840	COG2050	protein possibly involved in aromatic compounds catabolism
N4P52_11855	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N4P52_11865	COG0697	spore germination
N4P52_11875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N4P52_11880	COG3584	3D domain protein
N4P52_11890	COG1252	NADH dehydrogenase
N4P52_11895	COG0492	ferredoxin-NADP+ reductase activity
N4P52_11920	COG0316	Belongs to the HesB IscA family
N4P52_11925	COG4837	Protein of unknown function (DUF1462)
N4P52_11930	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
N4P52_11935	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N4P52_11940	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N4P52_11945	COG0647	UMP catabolic process
N4P52_11950	COG2445	Protein of unknown function DUF86
N4P52_11955	COG4470	Protein conserved in bacteria
N4P52_11965	COG0739	heme binding
N4P52_11975	COG3377	Domain of unknown function (DUF1805)
N4P52_11980	COG0737	Belongs to the 5'-nucleotidase family
N4P52_11985	COG0719	Fe-S assembly protein
N4P52_11990	COG0822	iron-sulfur transferase activity
N4P52_11995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N4P52_12000	COG0719	Fe-S assembly protein
N4P52_12005	COG0396	ATPase activity
N4P52_12015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N4P52_12020	COG0509	glycine decarboxylation via glycine cleavage system
N4P52_12025	COG1393	Belongs to the ArsC family
N4P52_12030	COG1960	acyl-CoA dehydrogenase activity
N4P52_12035	COG0183	Belongs to the thiolase family
N4P52_12040	COG1024	Enoyl-CoA hydratase
N4P52_12040	COG1250	3-hydroxyacyl-CoA dehydrogenase
N4P52_12055	COG5577	PFAM Coat F domain
N4P52_12060	COG0772	Belongs to the SEDS family
N4P52_12065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N4P52_12080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N4P52_12085	COG2200	EAL domain
N4P52_12085	COG2199	diguanylate cyclase activity
N4P52_12085	COG2202	Pas domain
N4P52_12090	COG0753	catalase activity
N4P52_12095	COG0671	phosphoesterase, PA-phosphatase related
N4P52_12105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N4P52_12120	COG1595	DNA-templated transcription, initiation
N4P52_12125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N4P52_12140	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N4P52_12155	COG2610	gluconate transmembrane transporter activity
N4P52_12160	COG1312	Catalyzes the dehydration of D-mannonate
N4P52_12165	COG0246	Mannitol dehydrogenase
N4P52_12170	COG2721	sulfolactate sulfo-lyase activity
N4P52_12175	COG0246	Mannitol dehydrogenase
N4P52_12185	COG0800	Aldolase
N4P52_12190	COG1414	Transcriptional regulator
N4P52_12195	COG3328	transposase activity
N4P52_12255	COG0557	exoribonuclease II activity
N4P52_12260	COG1647	Serine aminopeptidase, S33
N4P52_12265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N4P52_12275	COG0148	phosphopyruvate hydratase activity
N4P52_12280	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N4P52_12290	COG0126	phosphoglycerate kinase activity
N4P52_12310	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
N4P52_12330	COG3383	formate dehydrogenase (NAD+) activity
N4P52_12365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N4P52_12380	COG4608	Belongs to the ABC transporter superfamily
N4P52_12385	COG0791	NLP P60 protein
N4P52_12390	COG4166	transmembrane transport
N4P52_12395	COG0444	Belongs to the ABC transporter superfamily
N4P52_12400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N4P52_12405	COG0601	transmembrane transport
N4P52_12410	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N4P52_12420	COG0598	Magnesium transport protein CorA
N4P52_12430	COG2719	SpoVR family
N4P52_12435	COG3594	Acyltransferase
N4P52_12460	COG1392	Phosphate transport regulator
N4P52_12465	COG0306	phosphate transporter
N4P52_12480	COG2718	Belongs to the UPF0229 family
N4P52_12485	COG2766	serine protein kinase
N4P52_12490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N4P52_12505	COG2095	MarC family integral membrane protein
N4P52_12515	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
N4P52_12520	COG0596	Alpha beta hydrolase
N4P52_12525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4P52_12530	COG0765	amino acid transport
N4P52_12535	COG1126	abc transporter atp-binding protein
N4P52_12540	COG2116	formate transmembrane transporter activity
N4P52_12560	COG1882	Formate acetyltransferase
N4P52_12565	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N4P52_12570	COG0431	NADPH-dependent FMN reductase
N4P52_12585	COG1131	(ABC) transporter
N4P52_12610	COG0745	RESPONSE REGULATOR receiver
N4P52_12615	COG5002	protein histidine kinase activity
N4P52_12615	COG3850	Histidine kinase
N4P52_12625	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
N4P52_12630	COG2188	Transcriptional regulator
N4P52_12655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N4P52_12665	COG2323	membrane
N4P52_12770	COG3527	Alpha-acetolactate decarboxylase
N4P52_12775	COG0028	Belongs to the TPP enzyme family
N4P52_12780	COG0583	DNA-binding transcription factor activity
N4P52_12785	COG0735	belongs to the Fur family
N4P52_12800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N4P52_12805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N4P52_12810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N4P52_12815	COG1116	anion transmembrane transporter activity
N4P52_12820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N4P52_12825	COG2814	Major facilitator Superfamily
N4P52_12840	COG4129	membrane
N4P52_12845	COG1737	Transcriptional regulator
N4P52_12855	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
N4P52_12865	COG1132	(ABC) transporter
N4P52_12870	COG3557	Belongs to the UPF0374 family
N4P52_12885	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_12890	COG0583	DNA-binding transcription factor activity
N4P52_12895	COG0067	glutamate synthase
N4P52_12895	COG0069	glutamate synthase activity
N4P52_12895	COG0070	glutamate synthase
N4P52_12900	COG0493	'glutamate synthase
N4P52_12925	COG1988	membrane-bound metal-dependent
N4P52_12930	COG1194	a g-specific adenine glycosylase
N4P52_12955	COG0159	tryptophan synthase activity
N4P52_12965	COG0133	tryptophan synthase activity
N4P52_12970	COG0134	indole-3-glycerol-phosphate synthase activity
N4P52_12975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N4P52_12980	COG0512	Glutamine amidotransferase of anthranilate synthase
N4P52_12980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N4P52_12990	COG0577	efflux transmembrane transporter activity
N4P52_12995	COG0577	efflux transmembrane transporter activity
N4P52_12995	COG1136	(ABC) transporter
N4P52_13000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4P52_13020	COG1131	(ABC) transporter
N4P52_13055	COG2197	response regulator
N4P52_13060	COG4585	Histidine kinase
N4P52_13075	COG1012	belongs to the aldehyde dehydrogenase family
N4P52_13075	COG1012	belongs to the aldehyde dehydrogenase family
N4P52_13085	COG0058	SHG alpha-glucan phosphorylase activity
N4P52_13090	COG0840	transmembrane signaling receptor activity
N4P52_13095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N4P52_13100	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N4P52_13105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N4P52_13120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N4P52_13125	COG0066	3-isopropylmalate dehydratase activity
N4P52_13130	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N4P52_13140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N4P52_13145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N4P52_13150	COG0440	acetolactate synthase activity
N4P52_13155	COG0028	Belongs to the TPP enzyme family
N4P52_13160	COG0129	dihydroxy-acid dehydratase activity
N4P52_13165	COG1114	Component of the transport system for branched-chain amino acids
N4P52_13170	COG1366	Belongs to the anti-sigma-factor antagonist family
N4P52_13195	COG2124	cytochrome p450
N4P52_13200	COG0670	Belongs to the BI1 family
N4P52_13205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N4P52_13210	COG2223	nitrite transmembrane transporter activity
N4P52_13215	COG3279	Response regulator of the LytR AlgR family
N4P52_13220	COG3275	phosphorelay sensor kinase activity
N4P52_13225	COG0252	asparaginase activity
N4P52_13230	COG2132	Multicopper oxidase
N4P52_13235	COG1309	transcriptional regulator
N4P52_13240	COG1511	domain protein
N4P52_13280	COG3739	integral membrane protein
N4P52_13285	COG3655	Transcriptional regulator
N4P52_13300	COG1823	symporter activity
N4P52_13305	COG2839	Protein conserved in bacteria
N4P52_13330	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
N4P52_13335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N4P52_13340	COG1279	arginine transmembrane transporter activity
N4P52_13345	COG1132	(ABC) transporter
N4P52_13350	COG1846	Transcriptional regulator
N4P52_13355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N4P52_13375	COG1401	restriction endodeoxyribonuclease activity
N4P52_13395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N4P52_13400	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
N4P52_13420	COG0387	Pfam Sodium calcium exchanger
N4P52_13425	COG0477	Major facilitator Superfamily
N4P52_13430	COG1295	ribonuclease BN
N4P52_13435	COG4840	Belongs to the UPF0435 family
N4P52_13440	COG0024	Methionine aminopeptidase
N4P52_13445	COG0693	protein deglycase activity
N4P52_13450	COG1360	Flagellar Motor Protein
N4P52_13455	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N4P52_13465	COG3189	MarR family transcriptional regulator
N4P52_13475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N4P52_13480	COG1607	acyl-coa hydrolase
N4P52_13485	COG1077	Cell shape determining protein MreB Mrl
N4P52_13490	COG2268	Band 7 protein
N4P52_13495	COG1585	Membrane protein implicated in regulation of membrane protease activity
N4P52_13500	COG0626	cystathionine gamma-synthase activity
N4P52_13505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N4P52_13510	COG1854	S-ribosylhomocysteine lyase activity
N4P52_13515	COG2226	methyltransferase
N4P52_13520	COG0288	reversible hydration of carbon dioxide
N4P52_13525	COG0860	N-Acetylmuramoyl-L-alanine amidase
N4P52_13535	COG2197	response regulator
N4P52_13555	COG4086	secreted protein
N4P52_13560	COG0737	Belongs to the 5'-nucleotidase family
N4P52_13575	COG3620	sequence-specific DNA binding
N4P52_13585	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
N4P52_13590	COG1518	maintenance of DNA repeat elements
N4P52_13630	COG0778	Nitroreductase
N4P52_13640	COG1304	FMN binding
N4P52_13645	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
N4P52_13650	COG0166	Belongs to the GPI family
N4P52_13655	COG0025	NhaP-type Na H and K H
N4P52_13665	COG1349	DNA-binding transcription factor activity
N4P52_13675	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
N4P52_13685	COG0561	phosphatase activity
N4P52_13710	COG2814	Major facilitator Superfamily
N4P52_13715	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N4P52_13730	COG2357	RelA SpoT domain protein
N4P52_13735	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N4P52_13740	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
N4P52_13745	COG1461	Dihydroxyacetone kinase
N4P52_13750	COG2376	Dihydroxyacetone kinase
N4P52_13760	COG0778	Nitroreductase
N4P52_13765	COG1113	amino acid transport
N4P52_13770	COG0730	response to heat
N4P52_13775	COG2233	PERMEase
N4P52_13785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N4P52_13810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N4P52_13815	COG1024	Enoyl-CoA hydratase
N4P52_13820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N4P52_13825	COG0511	ligase activity, forming carbon-carbon bonds
N4P52_13830	COG0439	Biotin carboxylase
N4P52_13835	COG1960	acyl-CoA dehydrogenase activity
N4P52_13840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N4P52_13855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N4P52_13860	COG3829	transcription factor binding
N4P52_13870	COG0833	amino acid
N4P52_13875	COG1309	transcriptional regulator
N4P52_13905	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
N4P52_13910	COG1140	nitrate reductase beta subunit
N4P52_13920	COG2181	nitrate reductase activity
N4P52_13925	COG2223	nitrite transmembrane transporter activity
N4P52_13930	COG3588	fructose-bisphosphate aldolase
N4P52_13935	COG1657	PFAM Prenyltransferase squalene oxidase
N4P52_13940	COG1349	DNA-binding transcription factor activity
N4P52_14015	COG0753	catalase activity
N4P52_14040	COG5444	nuclease activity
N4P52_14055	COG4268	DNA restriction-modification system
N4P52_14060	COG1401	restriction endodeoxyribonuclease activity
N4P52_14075	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N4P52_14115	COG1280	lysine exporter protein (LysE YggA)
N4P52_14125	COG0386	Belongs to the glutathione peroxidase family
N4P52_14130	COG2190	(PTS) system
N4P52_14145	COG3403	YqcI/YcgG family
N4P52_14180	COG1328	CTP reductase activity
N4P52_14190	COG1063	alcohol dehydrogenase
N4P52_14195	COG1929	Belongs to the glycerate kinase type-1 family
N4P52_14210	COG1879	ABC-type sugar transport system periplasmic component
N4P52_14215	COG1172	Belongs to the binding-protein-dependent transport system permease family
N4P52_14220	COG1129	ABC transporter
N4P52_14225	COG1869	D-ribose catabolic process
N4P52_14230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N4P52_14235	COG1609	Transcriptional regulator
N4P52_14275	COG4549	nuclear export factor GLE1
N4P52_14280	COG2372	response to copper ion
N4P52_14280	COG1276	copper resistance
N4P52_14290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N4P52_14295	COG1609	Transcriptional regulator
N4P52_14310	COG5002	protein histidine kinase activity
N4P52_14315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N4P52_14320	COG1278	Cold shock
N4P52_14325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N4P52_14330	COG0697	spore germination
N4P52_14350	COG1472	Belongs to the glycosyl hydrolase 3 family
N4P52_14360	COG3876	Protein conserved in bacteria
N4P52_14375	COG1132	(ABC) transporter
N4P52_14380	COG1132	(ABC) transporter
N4P52_14400	COG1388	LysM domain
N4P52_14400	COG0791	NLP P60 protein
N4P52_14420	COG2272	Belongs to the type-B carboxylesterase lipase family
N4P52_14425	COG0154	amidase activity
N4P52_14430	COG0154	amidase activity
N4P52_14435	COG2814	Major facilitator Superfamily
N4P52_14490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N4P52_14490	COG3153	acetyltransferase
N4P52_14495	COG5583	Uncharacterized small protein (DUF2292)
N4P52_14500	COG0431	NADPH-dependent FMN reductase
N4P52_14505	COG1116	anion transmembrane transporter activity
N4P52_14510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N4P52_14515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N4P52_14520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N4P52_14545	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N4P52_14560	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
N4P52_14570	COG2390	Transcriptional regulator
N4P52_14580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N4P52_14590	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
N4P52_14605	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N4P52_14610	COG1984	allophanate hydrolase subunit 2
N4P52_14615	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
N4P52_14620	COG2814	Major facilitator Superfamily
N4P52_14625	COG1764	response to oxidative stress
N4P52_14630	COG1126	abc transporter atp-binding protein
N4P52_14635	COG0765	amino acid transport
N4P52_14640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4P52_14650	COG0626	cystathionine gamma-synthase activity
N4P52_14670	COG0800	Aldolase
N4P52_14695	COG0326	Molecular chaperone. Has ATPase activity
N4P52_14705	COG3335	DDE superfamily endonuclease
N4P52_14715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N4P52_14735	COG1064	alcohol dehydrogenase
N4P52_14785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N4P52_14790	COG1597	lipid kinase activity
N4P52_14815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N4P52_14820	COG0154	amidase activity
N4P52_14825	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N4P52_14830	COG2224	Isocitrate lyase
N4P52_14835	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N4P52_14840	COG4851	CamS sex pheromone cAM373 precursor
N4P52_14860	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
N4P52_14865	COG4496	protein, YerC YecD
N4P52_14870	COG1470	cell adhesion involved in biofilm formation
N4P52_14885	COG0151	Belongs to the GarS family
N4P52_14890	COG0138	bifunctional purine biosynthesis protein purh
N4P52_14895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N4P52_14900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N4P52_14905	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N4P52_14910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N4P52_14915	COG0047	phosphoribosylformylglycinamidine synthase activity
N4P52_14920	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N4P52_14930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N4P52_14935	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N4P52_14940	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N4P52_14950	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
N4P52_14955	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N4P52_14975	COG1301	dicarboxylic acid transport
N4P52_14985	COG3711	transcriptional antiterminator
N4P52_14990	COG2252	PERMEase
N4P52_15000	COG1132	(ABC) transporter
N4P52_15005	COG2814	Major facilitator Superfamily
N4P52_15010	COG2197	response regulator
N4P52_15015	COG3850	Histidine kinase
N4P52_15020	COG1131	(ABC) transporter
N4P52_15030	COG0842	Transport permease protein
N4P52_15045	COG0179	Fumarylacetoacetate (FAA) hydrolase
N4P52_15065	COG0824	Thioesterase
N4P52_15070	COG0318	PFAM AMP-dependent synthetase and ligase
N4P52_15075	COG0183	Belongs to the thiolase family
N4P52_15080	COG1024	Enoyl-CoA hydratase
N4P52_15085	COG1250	3-hydroxyacyl-CoA dehydrogenase
N4P52_15095	COG2814	Major facilitator Superfamily
N4P52_15105	COG0179	Fumarylacetoacetate (FAA) hydrolase
N4P52_15115	COG0471	metal ion transport
N4P52_15140	COG1131	(ABC) transporter
N4P52_15145	COG1725	Transcriptional regulator
N4P52_15150	COG1695	Transcriptional regulator
N4P52_15155	COG3479	Phenolic acid decarboxylase
N4P52_15160	COG2910	NAD(P)H-binding
N4P52_15165	COG1959	2 iron, 2 sulfur cluster binding
N4P52_15175	COG0535	radical SAM domain protein
N4P52_15180	COG1994	Peptidase M50
N4P52_15185	COG1131	(ABC) transporter
N4P52_15200	COG4372	Transposase
N4P52_15210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N4P52_15225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N4P52_15240	COG0425	Belongs to the sulfur carrier protein TusA family
N4P52_15245	COG2391	methyltransferase activity
N4P52_15255	COG1028	Short-chain dehydrogenase reductase Sdr
N4P52_15270	COG1132	(ABC) transporter
N4P52_15280	COG1137	ATPase activity
N4P52_15310	COG1120	ATPase activity
N4P52_15315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N4P52_15340	COG3620	sequence-specific DNA binding
N4P52_15355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N4P52_15355	COG0519	Catalyzes the synthesis of GMP from XMP
N4P52_15360	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N4P52_15365	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N4P52_15370	COG1335	isochorismatase
N4P52_15375	COG4948	Mandelate Racemase Muconate Lactonizing
N4P52_15385	COG0463	Glycosyl transferase, family 2
N4P52_15390	COG2246	polysaccharide biosynthetic process
N4P52_15395	COG0459	protein refolding
N4P52_15400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N4P52_15405	COG1266	CAAX protease self-immunity
N4P52_15415	COG0805	protein transport
N4P52_15420	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
N4P52_15425	COG0488	(ABC) transporter
N4P52_15435	COG0456	acetyltransferase
N4P52_15440	COG1214	PFAM Peptidase M22, glycoprotease
N4P52_15445	COG0802	atpase or kinase
N4P52_15530	COG3091	SprT-like family
N4P52_15540	COG2183	response to ionizing radiation
N4P52_15545	COG2208	phosphoserine phosphatase activity
N4P52_15550	COG1191	sigma factor activity
N4P52_15555	COG2172	sigma factor antagonist activity
N4P52_15560	COG1366	Belongs to the anti-sigma-factor antagonist family
N4P52_15565	COG2208	phosphoserine phosphatase activity
N4P52_15570	COG2172	sigma factor antagonist activity
N4P52_15575	COG1366	Belongs to the anti-sigma-factor antagonist family
N4P52_15580	COG1366	Belongs to the anti-sigma-factor antagonist family
N4P52_15585	COG2337	Toxic component of a toxin-antitoxin (TA) module
N4P52_15590	COG0864	Transcriptional regulator
N4P52_15600	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
N4P52_15605	COG0736	holo-[acyl-carrier-protein] synthase activity
N4P52_15610	COG0705	Rhomboid family
N4P52_15615	COG0513	Belongs to the DEAD box helicase family
N4P52_15625	COG1280	lysine exporter protein (LysE YggA)
N4P52_15630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N4P52_15635	COG1609	Transcriptional regulator
N4P52_15640	COG0366	Alpha amylase catalytic
N4P52_15650	COG2182	Extracellular solute-binding protein
N4P52_15655	COG1175	transmembrane transport
N4P52_15660	COG3833	ABC-type maltose transport systems, permease component
N4P52_15670	COG1554	hydrolase, family 65, central catalytic
N4P52_15680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N4P52_15685	COG1181	Belongs to the D-alanine--D-alanine ligase family
N4P52_15695	COG1253	flavin adenine dinucleotide binding
N4P52_15700	COG0789	Transcriptional regulator
N4P52_15705	COG1253	flavin adenine dinucleotide binding
N4P52_15720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N4P52_15735	COG0629	single-stranded DNA binding
N4P52_15745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N4P52_15750	COG4786	Flagellar basal body rod
N4P52_15755	COG4786	Flagellar basal body rod
N4P52_15760	COG1077	Cell shape determining protein MreB Mrl
N4P52_15765	COG1609	Transcriptional regulator
N4P52_15770	COG0739	heme binding
N4P52_15775	COG2385	sporulation resulting in formation of a cellular spore
N4P52_15780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N4P52_15790	COG4836	Membrane
N4P52_15795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N4P52_15800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N4P52_15805	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N4P52_15810	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N4P52_15815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N4P52_15825	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N4P52_15830	COG0356	it plays a direct role in the translocation of protons across the membrane
N4P52_15840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N4P52_15845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N4P52_15855	COG0698	ribose 5-phosphate isomerase
N4P52_15870	COG1971	Probably functions as a manganese efflux pump
N4P52_15875	COG0009	L-threonylcarbamoyladenylate synthase
N4P52_15890	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N4P52_15900	COG1435	thymidine kinase activity
N4P52_15905	COG0254	rRNA binding
N4P52_15910	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N4P52_15915	COG1494	fructose-1,6-bisphosphatase
N4P52_15920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N4P52_15925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N4P52_15930	COG0191	fructose-bisphosphate aldolase activity
N4P52_15935	COG2204	response regulator
N4P52_15950	COG1131	(ABC) transporter
N4P52_15955	COG1725	Transcriptional regulator
N4P52_15960	COG0504	CTP synthase activity
N4P52_15965	COG3343	RNA polymerase activity
N4P52_15970	COG1136	(ABC) transporter
N4P52_15980	COG1703	isobutyryl-CoA mutase activity
N4P52_15980	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N4P52_15980	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N4P52_15985	COG1309	transcriptional regulator
N4P52_15990	COG1960	acyl-CoA dehydrogenase activity
N4P52_15995	COG1960	acyl-CoA dehydrogenase activity
N4P52_16000	COG0183	Belongs to the thiolase family
N4P52_16005	COG2181	nitrate reductase activity
N4P52_16005	COG0247	lactate metabolic process
N4P52_16010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N4P52_16015	COG0018	arginyl-trna synthetase
N4P52_16025	COG0010	Belongs to the arginase family
N4P52_16030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N4P52_16040	COG1994	Peptidase M50
N4P52_16050	COG3465	dGTPase activity
N4P52_16055	COG1078	dGTPase activity
N4P52_16065	COG0095	Lipoate-protein ligase
N4P52_16075	COG0280	phosphate acetyltransferase
N4P52_16080	COG3253	May function as heme-dependent peroxidase
N4P52_16090	COG2363	Small membrane protein
N4P52_16100	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N4P52_16135	COG4555	ABC transporter
N4P52_16150	COG0351	phosphomethylpyrimidine kinase
N4P52_16165	COG0561	phosphatase activity
N4P52_16170	COG0514	ATP-dependent DNA helicase (RecQ)
N4P52_16175	COG1785	Belongs to the alkaline phosphatase family
N4P52_16180	COG1737	Transcriptional regulator
N4P52_16195	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N4P52_16205	COG1346	cytolysis
N4P52_16210	COG1380	Effector of murein hydrolase LrgA
N4P52_16215	COG0583	DNA-binding transcription factor activity
N4P52_16220	COG0367	asparagine synthase
N4P52_16240	COG2966	Psort location CytoplasmicMembrane, score
N4P52_16245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N4P52_16250	COG1966	Carbon starvation protein
N4P52_16260	COG3275	phosphorelay sensor kinase activity
N4P52_16265	COG1464	Belongs to the NlpA lipoprotein family
N4P52_16270	COG2011	ABC-type metal ion transport system permease component
N4P52_16275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N4P52_16280	COG1119	ATPase activity
N4P52_16295	COG0534	Mate efflux family protein
N4P52_16300	COG1442	glycosyl transferase family 8
N4P52_16305	COG2195	Cleaves the N-terminal amino acid of tripeptides
N4P52_16310	COG2814	Major facilitator Superfamily
N4P52_16320	COG0028	Belongs to the TPP enzyme family
N4P52_16325	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N4P52_16330	COG1132	(ABC) transporter
N4P52_16340	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N4P52_16360	COG2188	Transcriptional regulator
N4P52_16365	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
N4P52_16370	COG1366	Belongs to the anti-sigma-factor antagonist family
N4P52_16375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4P52_16405	COG3457	Alanine racemase
N4P52_16415	COG1126	abc transporter atp-binding protein
N4P52_16425	COG0765	amino acid transport
N4P52_16435	COG0579	oxidoreductase
N4P52_16440	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N4P52_16445	COG0732	type I restriction modification DNA specificity domain
N4P52_16460	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N4P52_16485	COG0300	oxidoreductase activity
N4P52_16495	COG1280	lysine exporter protein (LysE YggA)
N4P52_16505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N4P52_16530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N4P52_16535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N4P52_16540	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N4P52_16545	COG4853	Protein conserved in bacteria
N4P52_16550	COG4863	YycH protein
N4P52_16555	COG5002	protein histidine kinase activity
N4P52_16560	COG0745	RESPONSE REGULATOR receiver
N4P52_16575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N4P52_16580	COG0305	Participates in initiation and elongation during chromosome replication
N4P52_16585	COG0359	binds to the 23S rRNA
N4P52_16590	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
N4P52_16600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N4P52_16610	COG0360	Binds together with S18 to 16S ribosomal RNA
N4P52_16615	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N4P52_16620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N4P52_16620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N4P52_16625	COG0307	riboflavin synthase, alpha
N4P52_16630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N4P52_16630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N4P52_16635	COG0012	GTP binding
N4P52_16640	COG4481	Protein conserved in bacteria
N4P52_16645	COG0668	transmembrane transport
N4P52_16655	COG1811	Na channel or pump
N4P52_16660	COG1475	DNA binding
N4P52_16665	COG1192	Involved in chromosome partitioning
N4P52_16670	COG1475	DNA binding
N4P52_16675	COG0357	Ribosomal RNA small subunit methyltransferase G
N4P52_16680	COG0445	tRNA wobble uridine modification
N4P52_16685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N4P52_16690	COG1847	R3H domain protein
N4P52_16695	COG0706	membrane insertase activity
N4P52_16700	COG0594	ribonuclease P activity
N4P52_16705	COG0230	Belongs to the bacterial ribosomal protein bL34 family