locus-tag	class	description
AXE80_00010	ENOG4105CZ7	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
AXE80_00015	ENOG4105CHM	Aminotransferase
AXE80_00020	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
AXE80_00030	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
AXE80_00050	ENOG4107R37	Glutamate dehydrogenase
AXE80_00055	ENOG4106KS4	Sulfatase
AXE80_00070	ENOG4105C1J	atp-dependent rna helicase
AXE80_00085	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
AXE80_00095	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
AXE80_00120	ENOG4105CAK	Cell division ATP-binding protein ftsE
AXE80_00150	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
AXE80_00160	ENOG4108Z6B	deaminase
AXE80_00170	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
AXE80_00180	ENOG41090A1	ferritin
AXE80_00185	ENOG4105C9M	aspartyl-trna synthetase
AXE80_00190	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
AXE80_00195	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
AXE80_00200	ENOG4107T8J	thymidine kinase
AXE80_00235	ENOG41081UC	Inherit from COG: Competence protein
AXE80_00245	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
AXE80_00250	ENOG4105D6J	arsenicaL-resistance protein
AXE80_00265	ENOG41080HT	Transcriptional regulator, arsr family
AXE80_00270	ENOG4107T7F	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
AXE80_00280	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
AXE80_00290	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
AXE80_00295	ENOG4108Y6J	UPF0403 protein
AXE80_00310	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
AXE80_00320	ENOG4107YM1	mraZ protein
AXE80_00325	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
AXE80_00335	ENOG4105CJN	penicillin-binding protein
AXE80_00340	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
AXE80_00345	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
AXE80_00350	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
AXE80_00355	ENOG4105CNI	cell division protein FtsW
AXE80_00360	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
AXE80_00365	ENOG4105DFU	Cell wall formation (By similarity)
AXE80_00375	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
AXE80_00385	ENOG4105KTH	gatB Yqey
AXE80_00390	ENOG4108S4H	thioesterase Superfamily protein
AXE80_00400	ENOG4105ETE	Transcriptional regulator (LacI family
AXE80_00405	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
AXE80_00420	ENOG4105C5H	ABC transporter
AXE80_00445	ENOG4105CCT	upf0313 protein
AXE80_00450	ENOG4105CBG	Sulfatase
AXE80_00455	ENOG4105D64	Mechanosensitive ion channel
AXE80_00460	ENOG4105CBG	Sulfatase
AXE80_00470	ENOG4105CDH	Citrulline--aspartate ligase
AXE80_00475	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
AXE80_00480	ENOG4105C8Y	Acetylornithine aminotransferase
AXE80_00500	ENOG4107REN	Carbamoyltransferase
AXE80_00505	ENOG4107T6X	nag kinase
AXE80_00515	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
AXE80_00525	ENOG4105CH7	arginosuccinase
AXE80_00555	ENOG4108V1U	phospholipid-binding protein
AXE80_00560	ENOG4107QN2	dihydrolipoyl dehydrogenase
AXE80_00575	ENOG4105DGW	oligopeptidase A
AXE80_00580	ENOG4105CRQ	synthase (Component I)
AXE80_00585	ENOG4105DDQ	anthranilate synthase
AXE80_00590	ENOG4107RI6	Anthranilate phosphoribosyltransferase
AXE80_00595	ENOG4105DK0	Indole-3-glycerol phosphate synthase
AXE80_00600	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
AXE80_00605	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
AXE80_00610	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
AXE80_00615	ENOG41077A9	carbonic anhydrase
AXE80_00635	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
AXE80_00640	ENOG4105DTN	riboflavin biosynthesis protein ribF
AXE80_00650	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
AXE80_00660	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
AXE80_00665	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
AXE80_00680	ENOG4105C02	permease
AXE80_00685	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
AXE80_00690	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
AXE80_00705	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
AXE80_00710	ENOG4105C9A	Phoh family
AXE80_00715	ENOG4107QWK	SAICAR synthetase
AXE80_00725	ENOG4105E18	UPF0276 protein
AXE80_00750	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
AXE80_00755	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AXE80_00770	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
AXE80_00780	ENOG4105CHM	Aminotransferase
AXE80_00800	ENOG41072GX	Peptidase M22 Glycoprotease
AXE80_00830	ENOG4107R91	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
AXE80_00835	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
AXE80_00840	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
AXE80_00845	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
AXE80_00855	ENOG4105C8T	Leucyl-tRNA synthetase
AXE80_00860	ENOG4108HWS	Histidine kinase
AXE80_00870	ENOG4105E39	Enoyl-CoA hydratase
AXE80_00880	ENOG4105C7B	Threonine dehydratase
AXE80_00885	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
AXE80_00890	ENOG4108ZP8	Acetolactate synthase small subunit
AXE80_00895	ENOG4105C7K	acetolactate synthase
AXE80_00900	ENOG4105C01	Dihydroxy-acid dehydratase
AXE80_00910	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
AXE80_00915	ENOG4105D2N	Aldolase
AXE80_00925	ENOG4108RWN	rrna methyltransferase
AXE80_00935	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
AXE80_00940	ENOG41083MR	nifu domain-containing protein
AXE80_00955	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
AXE80_00965	ENOG4105RA3	Binds directly to 16S ribosomal RNA (By similarity)
AXE80_00975	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
AXE80_00980	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
AXE80_00990	ENOG4109015	Biopolymer transport protein exbD tolR
AXE80_01000	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
AXE80_01025	ENOG4107R5Z	Oxidoreductase domain protein
AXE80_01030	ENOG4107QQG	Dehydrogenase
AXE80_01035	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
AXE80_01040	ENOG4105DG6	mannose-6-phosphate isomerase
AXE80_01045	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
AXE80_01050	ENOG4108IJ1	Dehydrogenase
AXE80_01065	ENOG4106WTF	Glycosyl transferase, family 2
AXE80_01075	ENOG4105ER6	polysaccharide biosynthesis protein
AXE80_01095	ENOG4108PTS	heparinase ii
AXE80_01120	ENOG4105ER6	polysaccharide biosynthesis protein
AXE80_01130	ENOG4105CGN	Glycosyl transferase (Group 1
AXE80_01145	ENOG4105D75	Capsular exopolysaccharide family
AXE80_01155	ENOG4105CQC	Prephenate dehydratase
AXE80_01160	ENOG4105CHM	Aminotransferase
AXE80_01170	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
AXE80_01175	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
AXE80_01180	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
AXE80_01195	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
AXE80_01200	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
AXE80_01205	ENOG4105CJ1	ABC, transporter
AXE80_01225	ENOG4107RUZ	Sss sodium solute transporter superfamily
AXE80_01230	ENOG410667J	hydrolase
AXE80_01235	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
AXE80_01245	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
AXE80_01255	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
AXE80_01265	ENOG4105C10	Electron transfer flavoprotein
AXE80_01270	ENOG4105BZJ	Electron transfer flavoprotein
AXE80_01275	ENOG4105CPP	Dehydrogenase, E1 component
AXE80_01285	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
AXE80_01290	ENOG4105ZMH	deoxynucleoside kinase
AXE80_01300	ENOG4105C26	Dehydrogenase
AXE80_01305	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
AXE80_01315	ENOG4105DWV	Homoserine O-trans-acetylase
AXE80_01320	ENOG4105CFH	Aspartokinase
AXE80_01325	ENOG4105C28	cystathionine
AXE80_01340	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
AXE80_01345	ENOG4105D7N	magnesium and cobalt transport protein CorA
AXE80_01350	ENOG4105EGS	Mechanosensitive ion channel
AXE80_01355	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
AXE80_01360	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
AXE80_01380	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
AXE80_01385	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
AXE80_01390	ENOG4105VCQ	rubredoxin
AXE80_01395	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
AXE80_01405	ENOG4107SFQ	iron-sulfur binding
AXE80_01420	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
AXE80_01435	ENOG4108DEF	Globin
AXE80_01450	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
AXE80_01460	ENOG4105D7T	ABC transporter
AXE80_01465	ENOG4105D7T	ABC transporter
AXE80_01470	ENOG4105DG7	nitrate ABC transporter
AXE80_01475	ENOG4105D7T	ABC transporter
AXE80_01485	ENOG4107QZF	nitrite reductase NADPH large subunit
AXE80_01490	ENOG4107QZF	nitrite reductase NADPH large subunit
AXE80_01495	ENOG4107YXA	Transcriptional regulator, BadM Rrf2 family
AXE80_01515	ENOG4105C11	sulfate adenylyltransferase), subunit 2
AXE80_01520	ENOG4107QK2	May be the GTPase, regulating ATP sulfurylase activity (By similarity)
AXE80_01525	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
AXE80_01530	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
AXE80_01535	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
AXE80_01540	ENOG4105CAY	ferredoxin--nadp reductase
AXE80_01550	ENOG4108ZIT	Ferredoxin, 2FE-2S
AXE80_01575	ENOG4105CNT	hydrolase family 2
AXE80_01580	ENOG4105QRC	ig domain protein group 2 domain protein
AXE80_01590	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_01595	ENOG4105TT1	Ragb susd domain-containing protein
AXE80_01610	ENOG4105QRC	ig domain protein group 2 domain protein
AXE80_01620	ENOG4105CPQ	Dehydrogenase
AXE80_01630	ENOG4105CHR	reductase
AXE80_01640	ENOG4105C26	Dehydrogenase
AXE80_01645	ENOG41061MV	Arylsulfatase
AXE80_01650	ENOG4105DIA	mandelate racemase muconate lactonizing
AXE80_01655	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
AXE80_01680	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
AXE80_01685	ENOG4105CNI	cell division protein FtsW
AXE80_01690	ENOG4105CJN	penicillin-binding protein
AXE80_01705	ENOG4105DFF	Rod shape-determining protein mreb
AXE80_01710	ENOG4105DC1	bifunctional purine biosynthesis protein purh
AXE80_01735	ENOG4105CJW	magnesium transporter
AXE80_01740	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
AXE80_01750	ENOG4108SJC	Membrane
AXE80_01755	ENOG4108KF3	Electron transport protein SCO1 SenC
AXE80_01770	ENOG4105CCU	oxidase (Subunit III)
AXE80_01775	ENOG4107R3R	Cytochrome o ubiquinol oxidase subunit III
AXE80_01780	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
AXE80_01795	ENOG4105C3M	thioredoxin reductase
AXE80_01810	ENOG4108YBP	pseudouridine synthase
AXE80_01815	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
AXE80_01820	ENOG4105C2N	RNA methyltransferase TrmH family group 3
AXE80_01845	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
AXE80_01855	ENOG4105CFP	Peptidase U32
AXE80_01865	ENOG4105CIY	formyltetrahydrofolate deformylase
AXE80_01870	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
AXE80_01875	ENOG4105CEV	competence damage-inducible protein
AXE80_01880	ENOG4105KDC	50s ribosomal protein l28
AXE80_01885	ENOG41083ND	50S ribosomal protein L33
AXE80_01890	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
AXE80_01895	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
AXE80_01945	ENOG4105C7S	Dehydrogenase
AXE80_01950	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
AXE80_01980	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
AXE80_01995	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
AXE80_02005	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
AXE80_02010	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AXE80_02020	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
AXE80_02030	ENOG4105CXT	aspartate transcarbamylase
AXE80_02035	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
AXE80_02055	ENOG4105E2X	shikimate dehydrogenase
AXE80_02090	ENOG4105C3F	Signal peptidase i
AXE80_02095	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
AXE80_02105	ENOG4105FA0	parb-like partition protein
AXE80_02110	ENOG4107QJE	Chromosome Partitioning Protein
AXE80_02115	ENOG4105CIN	aminoacyl-histidine dipeptidase
AXE80_02130	ENOG4105CPP	Dehydrogenase, E1 component
AXE80_02140	ENOG4108URH	decarboxylase
AXE80_02160	ENOG41082IR	Excinuclease ABC C subunit domain protein
AXE80_02180	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
AXE80_02190	ENOG4105BZU	Histidine kinase
AXE80_02195	ENOG4105BZM	domain protein
AXE80_02200	ENOG4107SVH	Potassium channel protein
AXE80_02205	ENOG4105BZG	amino acid carrier protein
AXE80_02215	ENOG4105C1G	acyl-Coa dehydrogenase
AXE80_02220	ENOG41083X6	30S ribosomal protein S21
AXE80_02225	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AXE80_02255	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
AXE80_02275	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
AXE80_02280	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
AXE80_02285	ENOG4107VNI	ribosomal protein l10
AXE80_02290	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
AXE80_02295	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AXE80_02300	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AXE80_02315	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
AXE80_02320	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
AXE80_02325	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
AXE80_02345	ENOG4105C9U	ATP-dependent DNA helicase RecQ
AXE80_02370	ENOG4105F1N	DNA alkylation repair
AXE80_02385	ENOG4105CSR	polyphosphate kinase 2
AXE80_02400	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
AXE80_02435	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
AXE80_02460	ENOG4105CDU	Replicative dna helicase
AXE80_02465	ENOG4108HCJ	Hydrolase
AXE80_02470	ENOG4108RWN	rrna methyltransferase
AXE80_02475	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
AXE80_02480	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
AXE80_02485	ENOG41090R7	Ferric uptake
AXE80_02490	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
AXE80_02505	ENOG4105C8Y	Acetylornithine aminotransferase
AXE80_02510	ENOG4105ETE	Transcriptional regulator (LacI family
AXE80_02515	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
AXE80_02520	ENOG4105XDZ	Tripartite ATP-independent periplasmic transporter
AXE80_02525	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
AXE80_02530	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
AXE80_02535	ENOG4105CHR	reductase
AXE80_02540	ENOG4105DKQ	ROK family
AXE80_02545	ENOG4108HHA	Transketolase
AXE80_02560	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
AXE80_02585	ENOG4105C37	(CBS) domain
AXE80_02590	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
AXE80_02595	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
AXE80_02615	ENOG4108RR8	protoporphyrinogen oxidase
AXE80_02625	ENOG4105C9Q	fumarate hydratase class II
AXE80_02630	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AXE80_02645	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AXE80_02665	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
AXE80_02670	ENOG4105KNE	Phosphatidate cytidylyltransferase
AXE80_02680	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
AXE80_02700	ENOG4107RIV	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
AXE80_02705	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
AXE80_02725	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
AXE80_02730	ENOG4105CKK	Glycosyl transferase, family 2
AXE80_02740	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
AXE80_02755	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
AXE80_02790	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
AXE80_02800	ENOG41080B9	Binds together with S18 to 16S ribosomal RNA (By similarity)
AXE80_02805	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
AXE80_02810	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
AXE80_02820	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
AXE80_02855	ENOG4105DCF	alanine dehydrogenase
AXE80_02860	ENOG4105K8N	protein family UPF0079, ATPase
AXE80_02885	ENOG41061MV	Arylsulfatase
AXE80_02930	ENOG4105ENH	Sulfatase
AXE80_02940	ENOG4105CNT	hydrolase family 2
AXE80_02945	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_02970	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
AXE80_02980	ENOG4105VEJ	Heat shock protein
AXE80_02995	ENOG4105C6K	Malic enzyme
AXE80_03000	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
AXE80_03010	ENOG4105EE5	Membrane protein terC
AXE80_03015	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
AXE80_03020	ENOG4105VJV	50s ribosomal protein L35
AXE80_03025	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
AXE80_03030	ENOG4105C22	threonyL-tRNA synthetase
AXE80_03035	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
AXE80_03040	ENOG41068JE	domain protein
AXE80_03050	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
AXE80_03060	ENOG4108KF3	Electron transport protein SCO1 SenC
AXE80_03065	ENOG4105DZP	Membrane-associated zinc metalloprotease
AXE80_03075	ENOG4105K5M	30s ribosomal protein S16
AXE80_03080	ENOG4107YAY	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
AXE80_03085	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
AXE80_03090	ENOG4105M08	Membrane
AXE80_03100	ENOG4105CD3	dihydroorotase
AXE80_03105	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
AXE80_03130	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
AXE80_03140	ENOG4105CUT	histidyl-tRNA synthetase
AXE80_03145	ENOG4105EUJ	GTP cyclohydrolase i
AXE80_03155	ENOG4105EP8	Glycosyl Hydrolase Family 88
AXE80_03165	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
AXE80_03190	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
AXE80_03205	ENOG4105CBG	Sulfatase
AXE80_03250	ENOG41061MV	Arylsulfatase
AXE80_03260	ENOG41061MV	Arylsulfatase
AXE80_03305	ENOG41061MV	Arylsulfatase
AXE80_03315	ENOG41061MV	Arylsulfatase
AXE80_03320	ENOG4105ENH	Sulfatase
AXE80_03325	ENOG41061MV	Arylsulfatase
AXE80_03330	ENOG41061MV	Arylsulfatase
AXE80_03350	ENOG4105ENH	Sulfatase
AXE80_03355	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
AXE80_03365	ENOG41061MV	Arylsulfatase
AXE80_03390	ENOG41061MV	Arylsulfatase
AXE80_03410	ENOG4105CBG	Sulfatase
AXE80_03460	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_03465	ENOG4105TT1	Ragb susd domain-containing protein
AXE80_03485	ENOG41061MV	Arylsulfatase
AXE80_03505	ENOG41061MV	Arylsulfatase
AXE80_03515	ENOG4105CBG	Sulfatase
AXE80_03530	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_03560	ENOG4106KS4	Sulfatase
AXE80_03620	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
AXE80_03625	ENOG4105CHR	reductase
AXE80_03645	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
AXE80_03660	ENOG41080WS	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
AXE80_03675	ENOG4108YZA	Nitrogen regulatory protein pii
AXE80_03680	ENOG4108YZA	Nitrogen regulatory protein pii
AXE80_03690	ENOG4108YZA	Nitrogen regulatory protein pii
AXE80_03725	ENOG4105DHJ	ABC, transporter
AXE80_03745	ENOG4105CNT	hydrolase family 2
AXE80_03755	ENOG4105CBG	Sulfatase
AXE80_03760	ENOG4105CNT	hydrolase family 2
AXE80_03770	ENOG41061MV	Arylsulfatase
AXE80_03780	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_03790	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_03815	ENOG4105CHR	reductase
AXE80_03830	ENOG41081WG	50s ribosomal protein l31
AXE80_03835	ENOG4108IAB	Phoh family
AXE80_03845	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
AXE80_03850	ENOG4105CN1	protease
AXE80_03855	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
AXE80_03865	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
AXE80_03870	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
AXE80_03875	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
AXE80_03880	ENOG4105DUX	Transporter
AXE80_03910	ENOG4105KA0	thioesterase Superfamily protein
AXE80_03915	ENOG4105E4F	Isochorismate synthase
AXE80_03930	ENOG4105JVQ	RNA Polymerase
AXE80_03940	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
AXE80_03950	ENOG4105CD3	dihydroorotase
AXE80_03955	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
AXE80_03965	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
AXE80_03970	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
AXE80_03985	ENOG4105BZ1	(ABC) transporter
AXE80_03990	ENOG4107R6T	Involved in the transcription termination process (By similarity)
AXE80_04005	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
AXE80_04015	ENOG4105CAT	Cytidine monophosphate kinase
AXE80_04020	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
AXE80_04035	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
AXE80_04045	ENOG4105E0X	reductase
AXE80_04065	ENOG4107QTF	adenylosuccinate lyase
AXE80_04075	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
AXE80_04085	ENOG4105EA8	2-Nitropropane dioxygenase
AXE80_04105	ENOG4105F27	Major Facilitator
AXE80_04115	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
AXE80_04120	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
AXE80_04125	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
AXE80_04130	ENOG4105C19	ABC transporter
AXE80_04135	ENOG4105E9H	Lytic Murein transglycosylase
AXE80_04145	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
AXE80_04155	ENOG4108Z7R	Chaperone CsaA
AXE80_04160	ENOG4107QI1	Mate efflux family protein
AXE80_04170	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
AXE80_04185	ENOG4105FE9	pseudouridine synthase
AXE80_04210	ENOG4107XPB	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AXE80_04215	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
AXE80_04225	ENOG4107QIJ	Aconitate hydratase 2
AXE80_04235	ENOG4105E0A	ABC, transporter
AXE80_04240	ENOG4105EHG	Permease protein
AXE80_04245	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
AXE80_04250	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
AXE80_04260	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
AXE80_04265	ENOG4107U9T	Pfam:Ribonuclease_BN
AXE80_04270	ENOG4105CS2	ec 3.2.1.21
AXE80_04300	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
AXE80_04305	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
AXE80_04310	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
AXE80_04315	ENOG4105CIH	Imidazole acetol-phosphate transaminase
AXE80_04320	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
AXE80_04325	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
AXE80_04330	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
AXE80_04335	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
AXE80_04340	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
AXE80_04345	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
AXE80_04355	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
AXE80_04360	ENOG4105DCI	Phosphohydrolase
AXE80_04365	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
AXE80_04370	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
AXE80_04375	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
AXE80_04380	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
AXE80_04385	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
AXE80_04390	ENOG4105CHR	reductase
AXE80_04400	ENOG4105E0M	Sulfatase
AXE80_04405	ENOG4107VIJ	nudix hydrolase
AXE80_04430	ENOG41061MV	Arylsulfatase
AXE80_04435	ENOG4105F2W	methyltransferase
AXE80_04450	ENOG4108IJF	Heavy metal efflux pump, CzcA
AXE80_04465	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
AXE80_04470	ENOG41082MP	copper ion binding protein
AXE80_04495	ENOG4105E0K	tonB-dependent siderophore receptor
AXE80_04505	ENOG4107RNH	Outer membrane receptor FepA
AXE80_04545	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
AXE80_04555	ENOG4105CP7	Triose-phosphate isomerase
AXE80_04570	ENOG4105D9R	oxidoreductase
AXE80_04575	ENOG41061MV	Arylsulfatase
AXE80_04595	ENOG4107XVH	Transcriptional regulator
AXE80_04620	ENOG4108RMU	ferritin dps family protein
AXE80_04625	ENOG4105D64	Mechanosensitive ion channel
AXE80_04640	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
AXE80_04655	ENOG4105CA0	peroxidase
AXE80_04665	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
AXE80_04670	ENOG4105C4M	(Ubiquinol oxidase) subunit I
AXE80_04705	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
AXE80_04715	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
AXE80_04725	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
AXE80_04735	ENOG4105C98	muts2 protein
AXE80_04740	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
AXE80_04780	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
AXE80_04795	ENOG4105C5H	ABC transporter
AXE80_04800	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AXE80_04805	ENOG4105GR3	Histidine kinase
AXE80_04835	ENOG4105BZU	Histidine kinase
AXE80_04840	ENOG4107QNK	)-transporter
AXE80_04845	ENOG4108HKT	sucrose-6-phosphate hydrolase
AXE80_04850	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_04870	ENOG4105D7K	pfkb domain protein
AXE80_04890	ENOG4105CFH	Aspartokinase
AXE80_04895	ENOG4107RDY	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
AXE80_04900	ENOG4105D98	threonine synthase
AXE80_04905	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
AXE80_04910	ENOG4105CGY	Dna recombination protein
AXE80_04945	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
AXE80_04950	ENOG4105SFS	phosphoesterase RecJ domain protein
AXE80_04960	ENOG4108V1T	peptidylprolyl cis-trans isomerase
AXE80_04965	ENOG4105C8N	cysteinyl-tRNA synthetase
AXE80_04970	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
AXE80_04975	ENOG4107QZC	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
AXE80_04980	ENOG4105EQ6	Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity)
AXE80_04985	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
AXE80_05000	ENOG4105CNU	cell division protein FtsK
AXE80_05005	ENOG4107YR5	Diacylglycerol kinase
AXE80_05045	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
AXE80_05050	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
AXE80_05065	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
AXE80_05090	ENOG41076HS	cation diffusion facilitator family transporter
AXE80_05095	ENOG4108YZY	peptidylprolyl cis-trans isomerase
AXE80_05110	ENOG4107QN2	dihydrolipoyl dehydrogenase
AXE80_05115	ENOG4105C75	arginyL-tRNA synthetase
AXE80_05130	ENOG4105C59	p-type ATPase
AXE80_05165	ENOG4105C58	cytochrome c oxidase accessory protein ccog
AXE80_05205	ENOG4105EHZ	conserved protein UCP016719
AXE80_05215	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
AXE80_05220	ENOG4105K3M	)-transporter
AXE80_05225	ENOG4108WQI	RNA Polymerase
AXE80_05230	ENOG4107QJZ	Glycosyl transferase, family 2
AXE80_05250	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
AXE80_05255	ENOG4107R0I	Cell wall formation (By similarity)
AXE80_05275	ENOG4108JYZ	YitT family
AXE80_05280	ENOG4105II7	pyrroline-5-carboxylate reductase
AXE80_05285	ENOG4105CHM	Aminotransferase
AXE80_05295	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
AXE80_05305	ENOG4107SET	aldo keto reductase
AXE80_05310	ENOG4105CNG	UPF0061 protein
AXE80_05320	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
AXE80_05325	ENOG4105E0X	reductase
AXE80_05340	ENOG4105VIG	Sec-independent protein translocase protein TatC
AXE80_05370	ENOG4105D75	Capsular exopolysaccharide family
AXE80_05395	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
AXE80_05400	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
AXE80_05415	ENOG4105HCZ	
AXE80_05420	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
AXE80_05430	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
AXE80_05435	ENOG4105EYW	Ion transport protein
AXE80_05440	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
AXE80_05445	ENOG4105T16	Transcriptional regulator (AraC family)
AXE80_05450	ENOG4105C2C	drug resistance transporter, Bcr CflA
AXE80_05460	ENOG4105DFA	alanine racemase domain protein
AXE80_05470	ENOG4108JQ1	Dehydrogenase
AXE80_05475	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
AXE80_05485	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
AXE80_05530	ENOG4105DR9	pseudouridine synthase
AXE80_05560	ENOG4107RQD	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
AXE80_05565	ENOG4105BZU	Histidine kinase
AXE80_05585	ENOG4107QJZ	Glycosyl transferase, family 2
AXE80_05595	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
AXE80_05605	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AXE80_05610	ENOG4105ID8	Transcriptional regulator, ARAC family
AXE80_05615	ENOG41082BM	Transcriptional regulator, arsr family
AXE80_05695	ENOG41082BM	Transcriptional regulator, arsr family
AXE80_05715	ENOG4105CZ9	Domain of unknown function (DU1801)
AXE80_05735	ENOG4105NAE	bifunctional deaminase-reductase domain protein
AXE80_05845	ENOG4105CAY	ferredoxin--nadp reductase
AXE80_05865	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
AXE80_05870	ENOG4105ECR	NmrA family
AXE80_05905	ENOG4105BZU	Histidine kinase
AXE80_05920	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_05940	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
AXE80_05945	ENOG4105FDP	GntR family transcriptional regulator
AXE80_05955	ENOG4105CBG	Sulfatase
AXE80_05960	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
AXE80_05975	ENOG4105CBG	Sulfatase
AXE80_05985	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_06040	ENOG4105E4I	Glycoside hydrolase family 28
AXE80_06055	ENOG4107QZ2	Sulfatase
AXE80_06080	ENOG4105M10	Involved in the anomeric conversion of L-rhamnose (By similarity)
AXE80_06110	ENOG4105CNT	hydrolase family 2
AXE80_06130	ENOG41061MV	Arylsulfatase
AXE80_06135	ENOG4105CBG	Sulfatase
AXE80_06140	ENOG4106KS4	Sulfatase
AXE80_06160	ENOG4105C9F	isomerase
AXE80_06165	ENOG4105DET	Rhamnulokinase
AXE80_06170	ENOG4105DMF	Dehydrogenase
AXE80_06185	ENOG4105CA0	peroxidase
AXE80_06215	ENOG4105C3M	thioredoxin reductase
AXE80_06220	ENOG4105CKK	Glycosyl transferase, family 2
AXE80_06225	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
AXE80_06240	ENOG4105BZR	domain protein
AXE80_06245	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
AXE80_06250	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
AXE80_06270	ENOG41061MV	Arylsulfatase
AXE80_06275	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
AXE80_06290	ENOG41067MG	lrgb family
AXE80_06295	ENOG4105M6F	mutator MutT protein
AXE80_06305	ENOG4107QI6	Cysteine desulfurase
AXE80_06310	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
AXE80_06325	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
AXE80_06335	ENOG4105CSM	endonuclease III
AXE80_06350	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AXE80_06365	ENOG4107ZAE	6-carboxy-5,6,7,8-tetrahydropterin synthase
AXE80_06370	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
AXE80_06395	ENOG4105CA0	peroxidase
AXE80_06410	ENOG4105C25	Primosomal protein n'
AXE80_06425	ENOG4105DSF	transport protein
AXE80_06445	ENOG4108V06	Glutathione peroxidase
AXE80_06450	ENOG4105FJR	Lmbe family
AXE80_06460	ENOG4105BZU	Histidine kinase
AXE80_06465	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
AXE80_06490	ENOG4105DZ2	Transcriptional regulator
AXE80_06505	ENOG4105E0C	molybdate abc transporter
AXE80_06510	ENOG4105C9U	ATP-dependent DNA helicase RecQ
AXE80_06520	ENOG4105D49	3-dehydroquinate synthase
AXE80_06550	ENOG4105K5B	UPF0225 protein
AXE80_06555	ENOG4105C1G	acyl-Coa dehydrogenase
AXE80_06560	ENOG4105CHU	acetyl-coa acetyltransferase
AXE80_06575	ENOG4108IUX	(ABC) transporter
AXE80_06585	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
AXE80_06620	ENOG4108I6A	alcohol dehydrogenase
AXE80_06625	ENOG4108RCM	Nitroreductase
AXE80_06630	ENOG4105Y7M	Transcriptional regulator, TetR family
AXE80_06640	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
AXE80_06655	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
AXE80_06660	ENOG4105C2J	ABC transporter
AXE80_06665	ENOG4105CNN	ABC, transporter
AXE80_06670	ENOG4105DEI	Mannitol dehydrogenase
AXE80_06675	ENOG4108KPW	sugar kinase
AXE80_06680	ENOG4105ETE	Transcriptional regulator (LacI family
AXE80_06685	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_06695	ENOG4105D7K	pfkb domain protein
AXE80_06700	ENOG4107RK0	Sucrose phosphorylase
AXE80_06715	ENOG4108ZG0	Ompa motb domain protein
AXE80_06735	ENOG4108VVK	transcriptional Regulator, AsnC
AXE80_06750	ENOG4105CD8	aminopeptidase N
AXE80_06755	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
AXE80_06765	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
AXE80_06780	ENOG4105CE1	Ferrous iron transport protein b
AXE80_06820	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
AXE80_06825	ENOG4105CPC	Aldo Keto reductase
AXE80_06830	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
AXE80_06845	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
AXE80_06875	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
AXE80_06905	ENOG4105TT1	Ragb susd domain-containing protein
AXE80_06910	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_06915	ENOG4105CBG	Sulfatase
AXE80_06955	ENOG4105CPQ	Dehydrogenase
AXE80_06960	ENOG4105CTX	dehydratase
AXE80_06965	ENOG4107QZW	Altronate oxidoreductase
AXE80_06980	ENOG4105EDR	glucose galactose transporter
AXE80_06985	ENOG4105QJH	Domain of unknown function (DUF718)
AXE80_07075	ENOG4105C1J	atp-dependent rna helicase
AXE80_07140	ENOG4105P4J	Allophanate hydrolase, subunit 1
AXE80_07145	ENOG4105E7W	lamb ycsf family protein
AXE80_07175	ENOG4105CIF	Ornithine Cyclodeaminase
AXE80_07180	ENOG4105VC4	domain protein
AXE80_07185	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
AXE80_07190	ENOG4108I7H	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AXE80_07280	ENOG4105EXC	Acyl-transferase
AXE80_07330	ENOG4105C0H	protease
AXE80_07335	ENOG41061MV	Arylsulfatase
AXE80_07340	ENOG41061MV	Arylsulfatase
AXE80_07395	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_07400	ENOG4105CBG	Sulfatase
AXE80_07415	ENOG41061MV	Arylsulfatase
AXE80_07485	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
AXE80_07490	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
AXE80_07515	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
AXE80_07520	ENOG4105C0H	protease
AXE80_07530	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
AXE80_07540	ENOG4105HHA	aminodeoxychorismate lyase
AXE80_07545	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
AXE80_07555	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
AXE80_07560	ENOG41082UD	thioesterase Superfamily protein
AXE80_07565	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
AXE80_07570	ENOG4108TZV	Membrane
AXE80_07575	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
AXE80_07585	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
AXE80_07590	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
AXE80_07600	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
AXE80_07620	ENOG4105D5Q	Arginine ornithine antiporter
AXE80_07660	ENOG4105EWI	Short-chain dehydrogenase reductase Sdr
AXE80_07670	ENOG410874W	AraC family transcriptional regulator
AXE80_07710	ENOG4106HB6	Alpha beta hydrolase
AXE80_07720	ENOG4105C1J	atp-dependent rna helicase
AXE80_07725	ENOG4105BZ1	(ABC) transporter
AXE80_07745	ENOG4105D05	Receptor
AXE80_07760	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
AXE80_07765	ENOG4105NPQ	Pfam:DUF403
AXE80_07780	ENOG4105NPQ	Pfam:DUF403
AXE80_07795	ENOG4105M08	Membrane
AXE80_07825	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
AXE80_07835	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
AXE80_07865	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
AXE80_07875	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
AXE80_07880	ENOG4105D52	delta-aminolevulinic acid dehydratase
AXE80_07890	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
AXE80_07895	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
AXE80_07905	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
AXE80_07910	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
AXE80_07925	ENOG4105D4X	repressor
AXE80_07930	ENOG4105D2H	Uronic isomerase
AXE80_07935	ENOG41061MV	Arylsulfatase
AXE80_07940	ENOG41084I7	Alpha-galactosidase. Removes both branched alpha-1,3- linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures
AXE80_07945	ENOG4105CNT	hydrolase family 2
AXE80_07950	ENOG4105CBG	Sulfatase
AXE80_07955	ENOG4105CBG	Sulfatase
AXE80_07960	ENOG4105CBG	Sulfatase
AXE80_07965	ENOG41084I7	Alpha-galactosidase. Removes both branched alpha-1,3- linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures
AXE80_07970	ENOG4105CBG	Sulfatase
AXE80_07980	ENOG4105CNT	hydrolase family 2
AXE80_07985	ENOG41061MV	Arylsulfatase
AXE80_08005	ENOG4105CNT	hydrolase family 2
AXE80_08015	ENOG4105CBG	Sulfatase
AXE80_08025	ENOG41061MV	Arylsulfatase
AXE80_08030	ENOG4105CBG	Sulfatase
AXE80_08035	ENOG4105CBG	Sulfatase
AXE80_08060	ENOG41084I7	Alpha-galactosidase. Removes both branched alpha-1,3- linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures
AXE80_08070	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
AXE80_08075	ENOG4105CBG	Sulfatase
AXE80_08120	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_08125	ENOG4105BZU	Histidine kinase
AXE80_08135	ENOG4105CNT	hydrolase family 2
AXE80_08170	ENOG4105ESI	atpase involved in dna repair
AXE80_08175	ENOG4107J0C	type IIi
AXE80_08185	ENOG4107QMH	DNA methylase
AXE80_08195	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
AXE80_08205	ENOG4108RAV	Conserved protein
AXE80_08235	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AXE80_08245	ENOG4105K63	Thioredoxin
AXE80_08250	ENOG4105C3R	Methionine synthase
AXE80_08255	ENOG4105C3R	Methionine synthase
AXE80_08265	ENOG4105D17	glycoside hydrolase, family 3 domain protein
AXE80_08285	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
AXE80_08295	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
AXE80_08325	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
AXE80_08335	ENOG4105C9U	ATP-dependent DNA helicase RecQ
AXE80_08340	ENOG4105C2X	Arabinose 5-phosphate isomerase
AXE80_08345	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
AXE80_08350	ENOG4108IUZ	ABC transporter
AXE80_08385	ENOG4107T8Q	Glycosyl transferase (Group 1
AXE80_08395	ENOG4105CG5	Glycosyl transferase (Group 1
AXE80_08425	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
AXE80_08435	ENOG4108JQ1	Dehydrogenase
AXE80_08440	ENOG4105F0R	Cytidylyltransferase
AXE80_08445	ENOG4107SE4	UDP-N-acetylglucosamine 2-epimerase
AXE80_08450	ENOG4105D2T	synthase
AXE80_08470	ENOG4105MEV	Acyl-transferase
AXE80_08475	ENOG4105JNK	Glycosyl transferase (Group 1
AXE80_08480	ENOG4107S6X	Glycosyl transferase, family 2
AXE80_08485	ENOG4105K64	Glycosyl transferase, family 2
AXE80_08490	ENOG4107T8Q	Glycosyl transferase (Group 1
AXE80_08510	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
AXE80_08515	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AXE80_08520	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
AXE80_08555	ENOG4105DWY	Agmatine deiminase
AXE80_08565	ENOG4105VC4	domain protein
AXE80_08585	ENOG4105VEQ	Cold shock protein
AXE80_08590	ENOG4105EDR	glucose galactose transporter
AXE80_08600	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
AXE80_08635	ENOG41074B2	UPF0747 protein
AXE80_08655	ENOG4105D3R	alkyl hydroperoxide reductase
AXE80_08670	ENOG4105CZN	Potassium uptake protein
AXE80_08675	ENOG4107ZYR	domain protein
AXE80_08685	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
AXE80_08705	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
AXE80_08715	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
AXE80_08735	ENOG4105KIR	Thiol-disulfide oxidoreductase dcc
AXE80_08765	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
AXE80_08775	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
AXE80_08790	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
AXE80_08795	ENOG4105ECY	inositol monophosphatase
AXE80_08805	ENOG4105CFH	Aspartokinase
AXE80_08820	ENOG4105EE0	oxidoreductase
AXE80_08825	ENOG4107QZT	geranylgeranyl reductase
AXE80_08830	ENOG4105CRE	cytochrome C
AXE80_08840	ENOG4105CPK	Glycosyl transferase (Group 1
AXE80_08875	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_08905	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AXE80_08910	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AXE80_08915	ENOG4105CMG	Carbohydrate kinase
AXE80_08925	ENOG4105C9J	Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity)
AXE80_08930	ENOG4106HBX	Transcriptional Regulator AraC Family
AXE80_08940	ENOG4105C26	Dehydrogenase
AXE80_08945	ENOG4105EDR	glucose galactose transporter
AXE80_08950	ENOG4105DMF	Dehydrogenase
AXE80_08960	ENOG4107R5B	glutamine synthetase
AXE80_08965	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
AXE80_08970	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
AXE80_08975	ENOG4105EGD	dinuclear metal center protein, YbgI family
AXE80_08990	ENOG4105VEQ	Cold shock protein
AXE80_08995	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
AXE80_09000	ENOG4105CHV	Transcription elongation factor NusA
AXE80_09005	ENOG41090IP	Required for maturation of 30S ribosomal subunits (By similarity)
AXE80_09020	ENOG4108ZJ4	polysaccharide deacetylase
AXE80_09030	ENOG4105C2M	dna polymerase I
AXE80_09035	ENOG4105E0M	Sulfatase
AXE80_09040	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
AXE80_09045	ENOG4108UJD	30S ribosomal protein S9
AXE80_09050	ENOG4105CE9	30S ribosomal protein S2
AXE80_09055	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
AXE80_09060	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
AXE80_09065	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
AXE80_09075	ENOG4105CHH	sulfate transporter
AXE80_09120	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
AXE80_09135	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
AXE80_09140	ENOG4105VN1	Heat shock protein
AXE80_09150	ENOG4105CFG	Acts as a chaperone (By similarity)
AXE80_09160	ENOG4105D1Q	UPF0246 protein
AXE80_09165	ENOG4105C34	Pseudouridine synthase
AXE80_09175	ENOG4105CPF	Cell wall formation (By similarity)
AXE80_09180	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
AXE80_09210	ENOG4105BZ1	(ABC) transporter
AXE80_09240	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
AXE80_09245	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
AXE80_09250	ENOG4105DSQ	Nitric oxide reductase
AXE80_09260	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
AXE80_09290	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
AXE80_09295	ENOG4107RUZ	Sss sodium solute transporter superfamily
AXE80_09300	ENOG4105C93	Xylose Isomerase
AXE80_09305	ENOG4105CMG	Carbohydrate kinase
AXE80_09335	ENOG4105D3G	Pseudouridine synthase
AXE80_09345	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
AXE80_09365	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_09375	ENOG4105C72	UPF0176 protein
AXE80_09380	ENOG4107TPS	domain protein
AXE80_09400	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
AXE80_09410	ENOG410667J	hydrolase
AXE80_09425	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
AXE80_09435	ENOG4105D3R	alkyl hydroperoxide reductase
AXE80_09455	ENOG4105C5H	ABC transporter
AXE80_09460	ENOG4107RNU	major facilitator superfamily MFS_1
AXE80_09465	ENOG4107Y03	Nitroreductase
AXE80_09475	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
AXE80_09485	ENOG4108Z03	MAF-like protein
AXE80_09495	ENOG4108RMU	ferritin dps family protein
AXE80_09500	ENOG4105C5Q	Transcriptional regulator
AXE80_09505	ENOG4108IQE	Amp-dependent synthetase and ligase
AXE80_09515	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
AXE80_09520	ENOG4105BZ1	(ABC) transporter
AXE80_09530	ENOG4108JQC	penicillin-binding protein 1A
AXE80_09535	ENOG4108Z5K	methylglyoxal synthase
AXE80_09545	ENOG4105CTQ	phosphohexokinase
AXE80_09560	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
AXE80_09580	ENOG4105E6M	Sulphatase-modifying factor protein
AXE80_09585	ENOG4105C0B	DNA polymerase III (alpha subunit)
AXE80_09595	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
AXE80_09600	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
AXE80_09605	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
AXE80_09635	ENOG4105NBK	UPF0345 protein
AXE80_09645	ENOG4105BZ9	Cytochrome C oxidase, subunit I
AXE80_09675	ENOG4105QAX	Iron-sulfur
AXE80_09695	ENOG4105C5H	ABC transporter
AXE80_09705	ENOG4105EUB	pirin domain protein
AXE80_09725	ENOG4107QX3	carboxylase
AXE80_09730	ENOG4105CDY	transcriptional regulatory protein
AXE80_09770	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
AXE80_09795	ENOG4105HFZ	Membrane
AXE80_09810	ENOG4105WH1	Two component transcriptional regulator luxr family
AXE80_09820	ENOG41085GJ	domain protein
AXE80_09825	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
AXE80_09835	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
AXE80_09840	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
AXE80_09855	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
AXE80_09865	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
AXE80_09905	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
AXE80_09910	ENOG4108JQ1	Dehydrogenase
AXE80_09915	ENOG4105D7W	serine acetyltransferase
AXE80_09920	ENOG4105C6T	cysteine synthase
AXE80_09930	ENOG41081FY	multiple antibiotic resistance (MarC)-related
AXE80_09935	ENOG4105PGM	cation diffusion facilitator family transporter
AXE80_09955	ENOG4105CMR	udp-glucose 4-epimerase
AXE80_09975	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
AXE80_09980	ENOG4108XXK	NUDIX hydrolase
AXE80_09995	ENOG4105CH6	catalase
AXE80_10000	ENOG4105DWT	malate dehydrogenase (quinone)
AXE80_10005	ENOG4106AM8	polysaccharide lyase family 8
AXE80_10010	ENOG4105C1J	atp-dependent rna helicase
AXE80_10015	ENOG4107QKV	phosphomannomutase
AXE80_10025	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
AXE80_10050	ENOG4105DHU	Bile acid
AXE80_10065	ENOG41061MV	Arylsulfatase
AXE80_10070	ENOG4105CTM	Glycoside hydrolase family 5
AXE80_10105	ENOG4107RAN	Peptidase, M16
AXE80_10115	ENOG4105C26	Dehydrogenase
AXE80_10120	ENOG4105CXK	mandelate racemase muconate lactonizing
AXE80_10135	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_10140	ENOG4105ENH	Sulfatase
AXE80_10160	ENOG4105EI3	2-dehydro-3-deoxygalactonokinase EC 2.7.1.58
AXE80_10165	ENOG4108RTU	Aldolase
AXE80_10170	ENOG4105CF7	AraC family transcriptional regulator
AXE80_10175	ENOG41061MV	Arylsulfatase
AXE80_10205	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
AXE80_10210	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
AXE80_10225	ENOG4105ENH	Sulfatase
AXE80_10235	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
AXE80_10240	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
AXE80_10265	ENOG4105C4R	Atp-dependent dna helicase
AXE80_10270	ENOG4105EYW	Ion transport protein
AXE80_10275	ENOG4105EEI	dihydropteroate synthase
AXE80_10305	ENOG4108K2F	hydrolase Family 5
AXE80_10320	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
AXE80_10325	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
AXE80_10330	ENOG4105CBG	Sulfatase
AXE80_10335	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
AXE80_10345	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_10360	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
AXE80_10375	ENOG4105CBG	Sulfatase
AXE80_10420	ENOG4105TT1	Ragb susd domain-containing protein
AXE80_10425	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_10435	ENOG4105D9R	oxidoreductase
AXE80_10460	ENOG4105DEN	Luciferase family
AXE80_10465	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
AXE80_10480	ENOG4105J5G	Transferase hexapeptide repeat containing protein
AXE80_10485	ENOG4107FCW	Abortive infection protein
AXE80_10490	ENOG4105DTQ	mandelate racemase muconate lactonizing
AXE80_10505	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
AXE80_10510	ENOG4105DF6	Fe-S oxidoreductase
AXE80_10515	ENOG4105DF6	Fe-S oxidoreductase
AXE80_10535	ENOG4105C8B	TIGR00159 family
AXE80_10565	ENOG4108YZT	Adenosylcobinamide kinase
AXE80_10575	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
AXE80_10590	ENOG4105DF5	DNA topoisomerase IV, subunit A
AXE80_10595	ENOG4105DNX	Dna topoisomerase iv (Subunit b)
AXE80_10605	ENOG4105C3G	gtp-binding protein
AXE80_10615	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
AXE80_10625	ENOG4105DMW	Dehydrogenase reductase
AXE80_10630	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
AXE80_10635	ENOG4105DWY	Agmatine deiminase
AXE80_10650	ENOG4105DZ0	fad dependent oxidoreductase
AXE80_10655	ENOG4105C1J	atp-dependent rna helicase
AXE80_10665	ENOG4105C1J	atp-dependent rna helicase
AXE80_10670	ENOG4105C34	Pseudouridine synthase
AXE80_10685	ENOG4105CKK	Glycosyl transferase, family 2
AXE80_10695	ENOG4105BZ1	(ABC) transporter
AXE80_10700	ENOG4105C98	muts2 protein
AXE80_10710	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
AXE80_10825	ENOG4107H6E	
AXE80_10920	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
AXE80_10925	ENOG4108X3M	OsmC Ohr family protein
AXE80_10945	ENOG4105C26	Dehydrogenase
AXE80_10950	ENOG4105CSA	Coproporphyrinogen iii oxidase
AXE80_10955	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
AXE80_10970	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
AXE80_10975	ENOG4105CM2	brancheD-chain amino acid aminotransferase
AXE80_10980	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
AXE80_10985	ENOG4108IYU	L-aspartate oxidase
AXE80_11005	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
AXE80_11010	ENOG4108RG0	uracil-dna glycosylase
AXE80_11015	ENOG4107S4Z	Activates expression of the rhaBAD and rhaT operons (By similarity)
AXE80_11035	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
AXE80_11040	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
AXE80_11050	ENOG4105FE9	pseudouridine synthase
AXE80_11075	ENOG4105CBX	hi0933 family
AXE80_11080	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
AXE80_11105	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
AXE80_11115	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
AXE80_11130	ENOG4105C9U	ATP-dependent DNA helicase RecQ
AXE80_11135	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
AXE80_11140	ENOG4105K70	DNA-binding protein
AXE80_11145	ENOG4108UJU	UPF0301 protein
AXE80_11170	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AXE80_11180	ENOG4105DPW	Major facilitator superfamily MFS_1
AXE80_11185	ENOG4107YCY	Transcriptional regulator
AXE80_11210	ENOG4105C27	TonB-dependent Receptor Plug
AXE80_11225	ENOG4105EY3	heparinase II III family protein
AXE80_11235	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
AXE80_11240	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
AXE80_11255	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
AXE80_11290	ENOG4108TJN	glycosyl transferase group 1
AXE80_11295	ENOG4105CPK	Glycosyl transferase (Group 1
AXE80_11305	ENOG4107ZNS	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
AXE80_11315	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
AXE80_11320	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
AXE80_11325	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
AXE80_11330	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
AXE80_11335	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
AXE80_11345	ENOG4105DXN	mazG family
AXE80_11350	ENOG4108JMC	lipopolysaccharide core biosynthesis protein
AXE80_11355	ENOG4108JMC	lipopolysaccharide core biosynthesis protein
AXE80_11365	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
AXE80_11370	ENOG4108ZT0	50S ribosomal protein l17
AXE80_11375	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AXE80_11380	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
AXE80_11385	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
AXE80_11390	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AXE80_11395	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
AXE80_11400	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
AXE80_11405	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
AXE80_11410	ENOG41084HK	50S ribosomal protein L30
AXE80_11415	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
AXE80_11425	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
AXE80_11430	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
AXE80_11435	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
AXE80_11440	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AXE80_11445	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
AXE80_11450	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
AXE80_11455	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
AXE80_11460	ENOG4105WNB	50s ribosomal protein l29
AXE80_11465	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
AXE80_11470	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
AXE80_11475	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
AXE80_11480	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
AXE80_11485	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AXE80_11490	ENOG41082S5	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
AXE80_11495	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
AXE80_11500	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
AXE80_11505	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
AXE80_11510	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
AXE80_11515	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
AXE80_11520	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
AXE80_11535	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
AXE80_11540	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
AXE80_11545	ENOG4105CBG	Sulfatase
AXE80_11550	ENOG4105CBG	Sulfatase
AXE80_11560	ENOG4105WJF	
AXE80_11570	ENOG4107QZF	nitrite reductase NADPH large subunit
AXE80_11590	ENOG4105CND	Glycosyl transferase, family 2
AXE80_11605	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
AXE80_11615	ENOG4109015	Biopolymer transport protein exbD tolR
AXE80_11630	ENOG4105HDK	L-asparaginase
AXE80_11635	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
AXE80_11645	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
AXE80_11650	ENOG4105WXV	50S ribosomal protein L32
AXE80_11660	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
AXE80_11665	ENOG4108R6K	riboflavin synthase, subunit alpha
AXE80_11675	ENOG4105CKK	Glycosyl transferase, family 2
AXE80_11710	ENOG4105DY9	regulatoR
AXE80_11720	ENOG4105BZU	Histidine kinase
AXE80_11770	ENOG4105BZS	acriflavin resistance protein
AXE80_11800	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
AXE80_11805	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
AXE80_11815	ENOG4107RJ9	Cell division protein FtsX
AXE80_11820	ENOG4105H4N	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
AXE80_11830	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
AXE80_11845	ENOG4105QJH	Domain of unknown function (DUF718)
AXE80_11850	ENOG4105EDR	glucose galactose transporter
AXE80_11870	ENOG4105CPQ	Dehydrogenase
AXE80_11885	ENOG4107RUZ	Sss sodium solute transporter superfamily
AXE80_11910	ENOG4105CHU	acetyl-coa acetyltransferase
AXE80_11915	ENOG4107SN7	NLP P60 protein
AXE80_11925	ENOG4107QP7	CoA-transferase subunit A
AXE80_11935	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AXE80_11950	ENOG4105KT5	UmuD protein
AXE80_11955	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
AXE80_11995	ENOG4105C5Z	peptidase
AXE80_12005	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
AXE80_12010	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
AXE80_12015	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
AXE80_12025	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
AXE80_12035	ENOG4105NWN	ApaG protein
AXE80_12065	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
AXE80_12080	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
AXE80_12090	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
AXE80_12095	ENOG4105VG1	fes assembly suf system protein
AXE80_12115	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
AXE80_12130	ENOG4108K2F	hydrolase Family 5
AXE80_12135	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
AXE80_12140	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
AXE80_12150	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
AXE80_12155	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
AXE80_12185	ENOG4108K5P	(LipO)protein
AXE80_12190	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
AXE80_12200	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
AXE80_12215	ENOG4108QBX	(LipO)protein
AXE80_12230	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
AXE80_12245	ENOG4107S18	3-phosphoshikimate 1-carboxyvinyltransferase
AXE80_12250	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
AXE80_12255	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
AXE80_12265	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
AXE80_12280	ENOG4105DWF	phosphomethylpyrimidine kinase
AXE80_12290	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
AXE80_12300	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
AXE80_12305	ENOG4105D41	biosynthesis protein thiH
AXE80_12320	ENOG4105C9M	aspartyl-trna synthetase
AXE80_12340	ENOG4105C8P	)-transporter
AXE80_12350	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AXE80_12365	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
AXE80_12375	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
AXE80_12380	ENOG4105C1A	potassium transporter peripheral membrane
AXE80_12385	ENOG4105W5Q	DNA repair protein (RadC
AXE80_12400	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
AXE80_12415	ENOG4105D1H	recombination factor protein RarA
AXE80_12425	ENOG4106A4F	Removes the N-terminal methionine from nascent proteins (By similarity)
AXE80_12435	ENOG4108CSZ	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
AXE80_12440	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
AXE80_12450	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
AXE80_12455	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
AXE80_12460	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
AXE80_12465	ENOG4105UYK	outer membrane protein a
AXE80_12480	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AXE80_12485	ENOG4105DJV	ribulose-phosphate 3-epimerase
AXE80_12490	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
AXE80_12505	ENOG4105E9Q	Acyl-transferase
AXE80_12525	ENOG4105E6M	Sulphatase-modifying factor protein
AXE80_12540	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
AXE80_12545	ENOG4107WT5	transcriptional regulator (NifA
AXE80_12565	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
AXE80_12570	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
AXE80_12580	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
AXE80_12585	ENOG4107RWD	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
AXE80_12590	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
AXE80_12600	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
AXE80_12630	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
AXE80_12635	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
AXE80_12640	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
AXE80_12650	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
AXE80_12655	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
AXE80_12665	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
AXE80_12675	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
AXE80_12680	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
AXE80_12685	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
AXE80_12690	ENOG4105CBG	Sulfatase
AXE80_12695	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
AXE80_12715	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AXE80_12720	ENOG4105UYK	outer membrane protein a
AXE80_12740	ENOG4107RBD	ABC, transporter
AXE80_12745	ENOG4107RPQ	ABC transporter
AXE80_12750	ENOG4105DIK	(ABC) transporter
AXE80_12755	ENOG4105DSE	periplasmic solute binding protein
AXE80_12765	ENOG4105D05	Receptor
AXE80_12775	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
AXE80_12795	ENOG4107RW9	nh(3)-dependent nad( ) synthetase
AXE80_12820	ENOG4105VRT	cytoplasmic protein
AXE80_12825	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
AXE80_12835	ENOG4105DFU	Cell wall formation (By similarity)
AXE80_12845	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
AXE80_12855	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
AXE80_12865	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
AXE80_12870	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
AXE80_12875	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
AXE80_12880	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AXE80_12885	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
AXE80_12890	ENOG4105BZU	Histidine kinase
AXE80_12905	ENOG4105BZU	Histidine kinase
AXE80_12925	ENOG4105WH1	Two component transcriptional regulator luxr family
AXE80_12930	ENOG4105C0P	Mg chelatase subunit ChlI
AXE80_12945	ENOG4107V87	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity)
AXE80_12950	ENOG4105EV9	Alpha Beta Hydrolase
AXE80_12955	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
AXE80_12965	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
AXE80_12975	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
AXE80_12980	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AXE80_13000	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
AXE80_13020	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
AXE80_13025	ENOG4105CJ2	(LipO)protein
AXE80_13035	ENOG4107QNM	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity)
AXE80_13045	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
AXE80_13060	ENOG4105ER2	Ompa motb domain protein
AXE80_13065	ENOG4105CGK	Exodeoxyribonuclease III
AXE80_13070	ENOG4108JQC	penicillin-binding protein 1A
AXE80_13075	ENOG410647Z	gliding motility-associated lipoprotein GldH
AXE80_13080	ENOG4105MA4	psp1 domain protein
AXE80_13105	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
AXE80_13115	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
AXE80_13120	ENOG4105C6K	Malic enzyme
AXE80_13130	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
AXE80_13145	ENOG4107QP8	phosphohexose isomerase
AXE80_13165	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
AXE80_13170	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
AXE80_13175	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
AXE80_13180	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
AXE80_13185	ENOG4108B1Q	Ribonuclease
AXE80_13205	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
AXE80_13210	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
AXE80_13215	ENOG4105D78	K07001 NTE family protein
AXE80_13225	ENOG4105C03	ribonuclease
AXE80_13230	ENOG4105K70	DNA-binding protein
AXE80_13240	ENOG4108UUM	single-stranded DNA-binding protein
AXE80_13245	ENOG4105C37	(CBS) domain
AXE80_13270	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
AXE80_13275	ENOG4105K46	50S ribosomal protein l27
AXE80_13300	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
AXE80_13305	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
AXE80_13325	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AXE80_13330	ENOG4105BZU	Histidine kinase
AXE80_13335	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
AXE80_13340	ENOG4105C12	Phosphoribosylglycinamide synthetase
AXE80_13355	ENOG4105WG6	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
AXE80_13365	ENOG41060VI	Involved in DNA repair and RecF pathway recombination (By similarity)
AXE80_13375	ENOG41080ZE	Adenylate cyclase
AXE80_13380	ENOG4108UT2	hemolysin iii
AXE80_13385	ENOG4105C31	Tryptophanyl-tRNA synthetase
AXE80_13395	ENOG4105CNT	hydrolase family 2
AXE80_13410	ENOG4107Z7P	Ferredoxin
AXE80_13415	ENOG4106A3M	Cytochrome p-450
AXE80_13420	ENOG4108MCI	Transcriptional regulator, ARAC family
AXE80_13425	ENOG4105CPC	Aldo Keto reductase
AXE80_13430	ENOG4105BZA	Phosphoglycerate kinase
AXE80_13435	ENOG4107QRG	dna polymerase iii
AXE80_13440	ENOG4105BZU	Histidine kinase
AXE80_13455	ENOG4105DU6	RNA polymerase
AXE80_13480	ENOG4108NEV	two component transcriptional regulator, LytTR family
AXE80_13485	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
AXE80_13490	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
AXE80_13495	ENOG41080AX	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
AXE80_13500	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
AXE80_13520	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
AXE80_13530	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
AXE80_13540	ENOG4108YZG	isomerase
AXE80_13550	ENOG4105E6M	Sulphatase-modifying factor protein
AXE80_13560	ENOG4105CN1	protease
AXE80_13565	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
AXE80_13575	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
AXE80_13620	ENOG4105D64	Mechanosensitive ion channel
AXE80_13660	ENOG41080R2	UPF0102 protein
AXE80_13665	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
AXE80_13670	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
AXE80_13690	ENOG4105EW9	transcriptional regulator AsnC family
AXE80_13695	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
AXE80_13710	ENOG4107RAQ	aminopeptidase
AXE80_13725	ENOG4108JA2	transcriptioN-repair coupling factor
AXE80_13730	ENOG4108EF6	Proline imino-peptidase
AXE80_13735	ENOG4105DKW	ABC transporter
AXE80_13740	ENOG4105CTX	dehydratase
AXE80_13745	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
AXE80_13750	ENOG4105ERH	Fumarylacetoacetate hydrolase
AXE80_13755	ENOG4105DMF	Dehydrogenase
AXE80_13760	ENOG4107XMK	single-stranded DNA-binding protein
AXE80_13800	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
AXE80_13820	ENOG4105E33	succinate dehydrogenase
AXE80_13825	ENOG4108N5B	2-phosphosulfolactate phosphatase
AXE80_13830	ENOG4105F8V	Hydrolase, tatD family
AXE80_13835	ENOG4107R4J	Chloride channel
AXE80_13855	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
AXE80_13860	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
AXE80_13870	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
AXE80_13880	ENOG4105BZU	Histidine kinase
AXE80_13890	ENOG4105EN6	Membrane
AXE80_13895	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
AXE80_13935	ENOG4105CRK	lysyL-tRNA synthetase
AXE80_13945	ENOG4105NGQ	Thioredoxin
AXE80_13950	ENOG4105CX6	glutaminyL-tRNA synthetase
AXE80_13960	ENOG4105C7W	Xanthine dehydrogenase
AXE80_13965	ENOG4105XRQ	Xanthine dehydrogenase accessory factor
AXE80_13985	ENOG4108ZFX	Mannosyl-3-phosphoglycerate phosphatase
AXE80_13990	ENOG4105D1Z	hydroxypyruvate reductase
AXE80_13995	ENOG4105C3Q	Glycosyl transferase, family 2
AXE80_14000	ENOG4107QW3	Sucrose phosphorylase
AXE80_14005	ENOG4105C8F	Beta-lactamase domain protein
AXE80_14040	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
AXE80_14050	ENOG4107Z65	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
AXE80_14055	ENOG4107Z4P	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
AXE80_14060	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
AXE80_14065	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
AXE80_14085	ENOG4107UGT	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
AXE80_14140	ENOG4105C5H	ABC transporter
AXE80_14190	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)