locus-tag	class	description
AXE80_00010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AXE80_00015	COG0436	Aminotransferase
AXE80_00020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AXE80_00030	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AXE80_00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AXE80_00055	COG3119	arylsulfatase activity
AXE80_00060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXE80_00070	COG0513	Belongs to the DEAD box helicase family
AXE80_00085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AXE80_00095	COG0358	DNA primase activity
AXE80_00120	COG2884	Cell division ATP-binding protein ftsE
AXE80_00135	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AXE80_00150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AXE80_00160	COG0590	tRNA wobble adenosine to inosine editing
AXE80_00170	COG0584	glycerophosphoryl diester phosphodiesterase
AXE80_00180	COG1528	Iron-storage protein
AXE80_00185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AXE80_00190	COG1970	mechanosensitive ion channel activity
AXE80_00195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AXE80_00200	COG1435	thymidine kinase activity
AXE80_00235	COG1040	competence protein
AXE80_00245	COG0423	glycine-tRNA ligase activity
AXE80_00250	COG0798	PFAM Bile acid sodium symporter
AXE80_00265	COG0640	Transcriptional regulator
AXE80_00270	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AXE80_00280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AXE80_00290	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AXE80_00305	COG0564	pseudouridine synthase activity
AXE80_00310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AXE80_00320	COG2001	Belongs to the MraZ family
AXE80_00325	COG0275	rRNA processing
AXE80_00340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AXE80_00345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXE80_00350	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AXE80_00355	COG0772	Belongs to the SEDS family
AXE80_00360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AXE80_00365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AXE80_00385	COG1610	YqeY-like protein
AXE80_00390	COG1607	acyl-coa hydrolase
AXE80_00400	COG1609	Transcriptional regulator
AXE80_00405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AXE80_00405	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AXE80_00420	COG0488	(ABC) transporter
AXE80_00445	COG1032	radical SAM domain protein
AXE80_00450	COG3119	arylsulfatase activity
AXE80_00455	COG0668	transmembrane transport
AXE80_00460	COG3119	arylsulfatase activity
AXE80_00470	COG0137	argininosuccinate synthase activity
AXE80_00475	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AXE80_00480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AXE80_00505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AXE80_00515	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AXE80_00525	COG0165	Argininosuccinate lyase
AXE80_00555	COG1881	PFAM PEBP family protein
AXE80_00560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXE80_00575	COG0339	signal peptide processing
AXE80_00580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AXE80_00585	COG0512	Glutamine amidotransferase of anthranilate synthase
AXE80_00590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AXE80_00595	COG0134	indole-3-glycerol-phosphate synthase activity
AXE80_00600	COG0135	phosphoribosylanthranilate isomerase activity
AXE80_00605	COG0133	tryptophan synthase activity
AXE80_00610	COG0159	tryptophan synthase activity
AXE80_00615	COG0288	reversible hydration of carbon dioxide
AXE80_00635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AXE80_00640	COG0196	riboflavin kinase activity
AXE80_00650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AXE80_00660	COG0156	8-amino-7-oxononanoate synthase activity
AXE80_00665	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AXE80_00680	COG0628	permease
AXE80_00685	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AXE80_00705	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
AXE80_00710	COG1702	phosphate starvation-inducible protein PhoH
AXE80_00715	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AXE80_00725	COG3220	belongs to the UPF0276 family
AXE80_00750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AXE80_00750	COG3153	acetyltransferase
AXE80_00755	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AXE80_00770	COG0357	Ribosomal RNA small subunit methyltransferase G
AXE80_00800	COG1214	PFAM Peptidase M22, glycoprotease
AXE80_00830	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AXE80_00835	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AXE80_00840	COG0297	glycogen (starch) synthase activity
AXE80_00845	COG0481	GTPase activity
AXE80_00855	COG0495	leucyl-tRNA aminoacylation
AXE80_00860	COG5000	phosphorelay sensor kinase activity
AXE80_00870	COG1024	Enoyl-CoA hydratase
AXE80_00880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AXE80_00885	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AXE80_00890	COG0440	acetolactate synthase activity
AXE80_00895	COG0028	Belongs to the TPP enzyme family
AXE80_00900	COG0129	dihydroxy-acid dehydratase activity
AXE80_00910	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AXE80_00915	COG0191	fructose-bisphosphate aldolase activity
AXE80_00925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXE80_00935	COG2226	methyltransferase
AXE80_00940	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AXE80_00955	COG0442	prolyl-tRNA aminoacylation
AXE80_00965	COG0268	Binds directly to 16S ribosomal RNA
AXE80_00975	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AXE80_00980	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AXE80_00990	COG0848	biopolymer transport protein
AXE80_01000	COG0285	dihydrofolate synthase activity
AXE80_01030	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AXE80_01040	COG1482	cell wall glycoprotein biosynthetic process
AXE80_01045	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AXE80_01050	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AXE80_01075	COG2244	polysaccharide biosynthetic process
AXE80_01120	COG2244	polysaccharide biosynthetic process
AXE80_01130	COG0438	transferase activity, transferring glycosyl groups
AXE80_01145	COG3206	protein involved in exopolysaccharide biosynthesis
AXE80_01145	COG0489	protein tyrosine kinase activity
AXE80_01155	COG0077	Prephenate dehydratase
AXE80_01155	COG1605	Chorismate mutase
AXE80_01160	COG0436	Aminotransferase
AXE80_01165	COG0287	Prephenate dehydrogenase
AXE80_01170	COG1605	Chorismate mutase
AXE80_01170	COG0287	Prephenate dehydrogenase
AXE80_01175	COG1162	GTPase activity
AXE80_01180	COG1490	D-aminoacyl-tRNA deacylase activity
AXE80_01195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AXE80_01200	COG0321	lipoyl(octanoyl) transferase activity
AXE80_01205	COG1131	(ABC) transporter
AXE80_01225	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AXE80_01230	COG0561	phosphatase activity
AXE80_01235	COG0326	Molecular chaperone. Has ATPase activity
AXE80_01245	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AXE80_01255	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AXE80_01265	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AXE80_01270	COG2086	electron transfer activity
AXE80_01275	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXE80_01275	COG0022	dehydrogenase e1 component
AXE80_01285	COG1227	inorganic diphosphatase activity
AXE80_01290	COG1428	Deoxynucleoside kinase
AXE80_01300	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AXE80_01300	COG0506	proline dehydrogenase activity
AXE80_01300	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AXE80_01305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AXE80_01315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AXE80_01320	COG0527	aspartate kinase activity
AXE80_01320	COG0460	homoserine dehydrogenase
AXE80_01330	COG0300	oxidoreductase activity
AXE80_01340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AXE80_01345	COG0598	Magnesium transport protein CorA
AXE80_01350	COG1196	nuclear chromosome segregation
AXE80_01350	COG3264	Mechanosensitive ion channel
AXE80_01355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AXE80_01360	COG0521	Mo-molybdopterin cofactor biosynthetic process
AXE80_01360	COG0315	cyclic pyranopterin monophosphate synthase activity
AXE80_01380	COG0746	molybdenum cofactor guanylyltransferase activity
AXE80_01385	COG0303	'Molybdopterin
AXE80_01390	COG1773	rubredoxin
AXE80_01395	COG0243	molybdopterin cofactor binding
AXE80_01405	COG0437	4 iron, 4 sulfur cluster binding
AXE80_01420	COG0243	molybdopterin cofactor binding
AXE80_01435	COG1017	nitric oxide dioxygenase activity
AXE80_01435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AXE80_01460	COG1116	anion transmembrane transporter activity
AXE80_01465	COG1116	anion transmembrane transporter activity
AXE80_01470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AXE80_01475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AXE80_01475	COG1116	anion transmembrane transporter activity
AXE80_01485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXE80_01490	COG2146	nitrite reductase [NAD(P)H] activity
AXE80_01490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXE80_01495	COG1959	2 iron, 2 sulfur cluster binding
AXE80_01515	COG0175	sulfate reduction
AXE80_01520	COG2895	sulfate adenylyltransferase (ATP) activity
AXE80_01525	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXE80_01535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AXE80_01535	COG1648	precorrin-2 dehydrogenase activity
AXE80_01540	COG0492	ferredoxin-NADP+ reductase activity
AXE80_01550	COG0633	Ferredoxin
AXE80_01565	COG1595	DNA-templated transcription, initiation
AXE80_01575	COG3250	beta-galactosidase activity
AXE80_01590	COG1629	transport
AXE80_01590	COG4206	TonB-dependent receptor
AXE80_01595	COG0561	phosphatase activity
AXE80_01620	COG1063	alcohol dehydrogenase
AXE80_01625	COG1472	Belongs to the glycosyl hydrolase 3 family
AXE80_01630	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_01640	COG1012	belongs to the aldehyde dehydrogenase family
AXE80_01645	COG3119	arylsulfatase activity
AXE80_01650	COG4948	Mandelate Racemase Muconate Lactonizing
AXE80_01655	COG2017	converts alpha-aldose to the beta-anomer
AXE80_01680	COG0284	orotidine-5'-phosphate decarboxylase activity
AXE80_01685	COG0772	Belongs to the SEDS family
AXE80_01690	COG0768	penicillin binding
AXE80_01705	COG1077	Cell shape determining protein MreB Mrl
AXE80_01710	COG0138	bifunctional purine biosynthesis protein purh
AXE80_01735	COG2239	Acts as a magnesium transporter
AXE80_01740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AXE80_01750	COG2322	membrane
AXE80_01755	COG1999	signal sequence binding
AXE80_01770	COG1845	cytochrome c oxidase, subunit III
AXE80_01775	COG1845	cytochrome c oxidase, subunit III
AXE80_01780	COG0109	protoheme IX farnesyltransferase activity
AXE80_01795	COG0492	ferredoxin-NADP+ reductase activity
AXE80_01810	COG0564	pseudouridine synthase activity
AXE80_01815	COG2824	Alkylphosphonate utilization operon protein PhnA
AXE80_01820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXE80_01845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AXE80_01855	COG0826	peptidase U32
AXE80_01865	COG0788	formyltetrahydrofolate deformylase activity
AXE80_01870	COG0179	Fumarylacetoacetate (FAA) hydrolase
AXE80_01875	COG1058	Belongs to the CinA family
AXE80_01875	COG1546	Belongs to the CinA family
AXE80_01880	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AXE80_01885	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AXE80_01890	COG0552	protein localization to endoplasmic reticulum
AXE80_01895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXE80_01950	COG0567	Dehydrogenase, E1 component
AXE80_01980	COG2255	four-way junction helicase activity
AXE80_01995	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AXE80_02005	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AXE80_02010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AXE80_02015	COG0616	signal peptide processing
AXE80_02020	COG1234	tRNA 3'-trailer cleavage
AXE80_02030	COG0540	Belongs to the ATCase OTCase family
AXE80_02035	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AXE80_02055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AXE80_02090	COG0681	Belongs to the peptidase S26 family
AXE80_02095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AXE80_02105	COG1475	DNA binding
AXE80_02110	COG1192	Involved in chromosome partitioning
AXE80_02115	COG2195	Cleaves the N-terminal amino acid of tripeptides
AXE80_02120	COG0778	Nitroreductase
AXE80_02130	COG0022	dehydrogenase e1 component
AXE80_02140	COG1611	Belongs to the LOG family
AXE80_02160	COG2827	Endonuclease containing a URI domain
AXE80_02195	COG2183	response to ionizing radiation
AXE80_02200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AXE80_02205	COG1115	amino acid carrier protein
AXE80_02215	COG1960	acyl-CoA dehydrogenase activity
AXE80_02220	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AXE80_02225	COG4974	Belongs to the 'phage' integrase family
AXE80_02275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AXE80_02280	COG0081	regulation of translation
AXE80_02285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AXE80_02290	COG0222	ribosome binding
AXE80_02295	COG0085	RNA polymerase activity
AXE80_02300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AXE80_02315	COG0706	membrane insertase activity
AXE80_02320	COG0504	CTP synthase activity
AXE80_02325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AXE80_02345	COG0551	DNA topoisomerase type I activity
AXE80_02345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AXE80_02370	COG4335	DNA alkylation repair
AXE80_02400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AXE80_02400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXE80_02425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AXE80_02435	COG0167	dihydroorotate dehydrogenase activity
AXE80_02455	COG2755	lipolytic protein G-D-S-L family
AXE80_02455	COG0657	acetylesterase activity
AXE80_02460	COG0305	Participates in initiation and elongation during chromosome replication
AXE80_02465	COG0561	phosphatase activity
AXE80_02470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXE80_02475	COG0501	Belongs to the peptidase M48B family
AXE80_02480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXE80_02490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AXE80_02505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AXE80_02510	COG1609	Transcriptional regulator
AXE80_02520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AXE80_02530	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AXE80_02535	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_02540	COG1940	carbohydrate kinase activity
AXE80_02545	COG3959	Transketolase, thiamine diphosphate binding domain
AXE80_02560	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AXE80_02585	COG1253	flavin adenine dinucleotide binding
AXE80_02590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXE80_02595	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AXE80_02605	COG1187	pseudouridine synthase activity
AXE80_02610	COG1285	pathogenesis
AXE80_02630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXE80_02640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AXE80_02645	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AXE80_02645	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AXE80_02665	COG0688	phosphatidylethanolamine metabolic process
AXE80_02670	COG4589	Belongs to the CDS family
AXE80_02680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AXE80_02700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AXE80_02705	COG0494	nUDIX hydrolase
AXE80_02725	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AXE80_02730	COG0463	Glycosyl transferase, family 2
AXE80_02740	COG0539	negative regulation of cytoplasmic translation
AXE80_02755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AXE80_02760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AXE80_02800	COG0360	Binds together with S18 to 16S ribosomal RNA
AXE80_02805	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AXE80_02810	COG0359	binds to the 23S rRNA
AXE80_02855	COG0686	Belongs to the AlaDH PNT family
AXE80_02860	COG0802	atpase or kinase
AXE80_02885	COG3119	arylsulfatase activity
AXE80_02930	COG3119	arylsulfatase activity
AXE80_02945	COG1629	transport
AXE80_02945	COG4206	TonB-dependent receptor
AXE80_02970	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AXE80_02980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AXE80_02995	COG0857	belongs to the CobB CobQ family
AXE80_02995	COG0280	phosphate acetyltransferase
AXE80_03000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AXE80_03010	COG1253	flavin adenine dinucleotide binding
AXE80_03015	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AXE80_03020	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AXE80_03025	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AXE80_03030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AXE80_03035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AXE80_03035	COG0519	Catalyzes the synthesis of GMP from XMP
AXE80_03040	COG1388	LysM domain
AXE80_03040	COG3942	CHAP domain
AXE80_03050	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AXE80_03055	COG1418	mRNA catabolic process
AXE80_03060	COG1999	signal sequence binding
AXE80_03065	COG0750	zinc metalloprotease
AXE80_03075	COG0228	four-way junction DNA binding
AXE80_03080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AXE80_03085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AXE80_03090	COG2363	Small membrane protein
AXE80_03100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AXE80_03105	COG1216	Glycosyl transferase, family 2
AXE80_03140	COG0124	histidyl-tRNA synthetase
AXE80_03145	COG0302	gtp cyclohydrolase
AXE80_03165	COG1472	Belongs to the glycosyl hydrolase 3 family
AXE80_03180	COG2814	Major facilitator Superfamily
AXE80_03200	COG1082	Xylose isomerase domain protein TIM barrel
AXE80_03205	COG3119	arylsulfatase activity
AXE80_03250	COG3119	arylsulfatase activity
AXE80_03260	COG3119	arylsulfatase activity
AXE80_03305	COG3119	arylsulfatase activity
AXE80_03315	COG3119	arylsulfatase activity
AXE80_03320	COG3119	arylsulfatase activity
AXE80_03325	COG3119	arylsulfatase activity
AXE80_03330	COG3119	arylsulfatase activity
AXE80_03350	COG3119	arylsulfatase activity
AXE80_03365	COG3119	arylsulfatase activity
AXE80_03390	COG3119	arylsulfatase activity
AXE80_03405	COG1501	Belongs to the glycosyl hydrolase 31 family
AXE80_03410	COG3119	arylsulfatase activity
AXE80_03435	COG3507	Belongs to the glycosyl hydrolase 43 family
AXE80_03460	COG1629	transport
AXE80_03460	COG4206	TonB-dependent receptor
AXE80_03465	COG0561	phosphatase activity
AXE80_03485	COG3119	arylsulfatase activity
AXE80_03505	COG3119	arylsulfatase activity
AXE80_03515	COG3119	arylsulfatase activity
AXE80_03530	COG4206	TonB-dependent receptor
AXE80_03530	COG1629	transport
AXE80_03560	COG3119	arylsulfatase activity
AXE80_03575	COG3507	Belongs to the glycosyl hydrolase 43 family
AXE80_03620	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AXE80_03625	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_03640	COG0010	Belongs to the arginase family
AXE80_03645	COG1166	arginine decarboxylase activity
AXE80_03660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AXE80_03670	COG0004	ammonium transporteR
AXE80_03675	COG0347	Belongs to the P(II) protein family
AXE80_03680	COG0347	Belongs to the P(II) protein family
AXE80_03685	COG0004	ammonium transporteR
AXE80_03690	COG0347	Belongs to the P(II) protein family
AXE80_03710	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXE80_03720	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AXE80_03725	COG1127	ABC transporter
AXE80_03745	COG3250	beta-galactosidase activity
AXE80_03755	COG3119	arylsulfatase activity
AXE80_03760	COG3250	beta-galactosidase activity
AXE80_03770	COG3119	arylsulfatase activity
AXE80_03780	COG1629	transport
AXE80_03780	COG4206	TonB-dependent receptor
AXE80_03790	COG4206	TonB-dependent receptor
AXE80_03790	COG1629	transport
AXE80_03815	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_03830	COG0254	rRNA binding
AXE80_03835	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AXE80_03845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AXE80_03855	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AXE80_03865	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXE80_03870	COG2333	competence protein COMEC
AXE80_03870	COG0658	competence protein
AXE80_03875	COG4232	protein-disulfide reductase activity
AXE80_03880	COG3104	oligopeptide transport
AXE80_03915	COG1169	isochorismate synthase
AXE80_03930	COG1595	DNA-templated transcription, initiation
AXE80_03940	COG0321	lipoyl(octanoyl) transferase activity
AXE80_03940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AXE80_03950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AXE80_03955	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AXE80_03965	COG0045	succinate-CoA ligase (ADP-forming) activity
AXE80_03970	COG0045	succinate-CoA ligase (ADP-forming) activity
AXE80_03985	COG1132	(ABC) transporter
AXE80_03990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXE80_04005	COG0237	dephospho-CoA kinase activity
AXE80_04015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AXE80_04020	COG0602	queuosine metabolic process
AXE80_04030	COG1472	Belongs to the glycosyl hydrolase 3 family
AXE80_04035	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AXE80_04040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AXE80_04045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXE80_04075	COG0482	sulfurtransferase activity
AXE80_04105	COG2814	Major facilitator Superfamily
AXE80_04115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXE80_04120	COG1136	(ABC) transporter
AXE80_04120	COG0577	efflux transmembrane transporter activity
AXE80_04125	COG1136	(ABC) transporter
AXE80_04125	COG0577	efflux transmembrane transporter activity
AXE80_04130	COG1136	(ABC) transporter
AXE80_04135	COG1388	LysM domain
AXE80_04135	COG0741	lytic transglycosylase activity
AXE80_04145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXE80_04150	COG4166	transmembrane transport
AXE80_04155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXE80_04160	COG0534	Mate efflux family protein
AXE80_04170	COG0009	L-threonylcarbamoyladenylate synthase
AXE80_04185	COG1187	pseudouridine synthase activity
AXE80_04210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AXE80_04215	COG0484	heat shock protein binding
AXE80_04230	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AXE80_04235	COG1120	ATPase activity
AXE80_04240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AXE80_04245	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AXE80_04250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AXE80_04265	COG1295	ribonuclease BN
AXE80_04270	COG2723	6-phospho-beta-galactosidase activity
AXE80_04300	COG4067	protein conserved in archaea
AXE80_04300	COG0189	ligase activity
AXE80_04305	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AXE80_04310	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AXE80_04315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AXE80_04320	COG0131	Imidazoleglycerol-phosphate dehydratase
AXE80_04325	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AXE80_04330	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AXE80_04335	COG0107	imidazoleglycerol-phosphate synthase activity
AXE80_04340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AXE80_04340	COG0140	phosphoribosyl-ATP diphosphatase activity
AXE80_04345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AXE80_04355	COG2204	response regulator
AXE80_04360	COG1078	dGTPase activity
AXE80_04365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXE80_04370	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AXE80_04370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AXE80_04375	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXE80_04380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AXE80_04385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AXE80_04390	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_04400	COG1368	sulfuric ester hydrolase activity
AXE80_04405	COG0494	nUDIX hydrolase
AXE80_04430	COG3119	arylsulfatase activity
AXE80_04435	COG2226	methyltransferase
AXE80_04450	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AXE80_04460	COG2608	mercury ion transmembrane transporter activity
AXE80_04465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXE80_04470	COG2608	mercury ion transmembrane transporter activity
AXE80_04495	COG4774	siderophore transport
AXE80_04545	COG2264	protein methyltransferase activity
AXE80_04555	COG0149	triose-phosphate isomerase activity
AXE80_04570	COG0673	inositol 2-dehydrogenase activity
AXE80_04575	COG3119	arylsulfatase activity
AXE80_04620	COG0783	Belongs to the Dps family
AXE80_04625	COG0668	transmembrane transport
AXE80_04655	COG1858	cytochrome C peroxidase
AXE80_04665	COG1294	oxidase, subunit
AXE80_04670	COG1271	oxidase subunit
AXE80_04705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AXE80_04715	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AXE80_04725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AXE80_04735	COG1193	negative regulation of DNA recombination
AXE80_04740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AXE80_04780	COG4628	conserved protein (DUF2132)
AXE80_04795	COG0488	(ABC) transporter
AXE80_04800	COG0745	RESPONSE REGULATOR receiver
AXE80_04805	COG5002	protein histidine kinase activity
AXE80_04840	COG2814	Major facilitator Superfamily
AXE80_04845	COG1621	beta-fructofuranosidase activity
AXE80_04850	COG1629	transport
AXE80_04850	COG4206	TonB-dependent receptor
AXE80_04890	COG0460	homoserine dehydrogenase
AXE80_04890	COG0527	aspartate kinase activity
AXE80_04895	COG0083	homoserine kinase activity
AXE80_04900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AXE80_04905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AXE80_04945	COG0105	UTP biosynthetic process
AXE80_04950	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AXE80_04965	COG0215	cysteine-tRNA ligase activity
AXE80_04970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AXE80_04975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AXE80_04980	COG3340	Belongs to the peptidase S51 family
AXE80_04985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AXE80_04985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AXE80_05000	COG1674	ftsk spoiiie
AXE80_05005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AXE80_05045	COG0019	diaminopimelate decarboxylase activity
AXE80_05050	COG2195	Cleaves the N-terminal amino acid of tripeptides
AXE80_05065	COG2706	6-phosphogluconolactonase activity
AXE80_05090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AXE80_05110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXE80_05115	COG0018	arginyl-trna synthetase
AXE80_05130	COG2217	Heavy metal translocating P-type atpase
AXE80_05165	COG0348	domain, Protein
AXE80_05180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AXE80_05205	COG3876	Protein conserved in bacteria
AXE80_05215	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AXE80_05225	COG1595	DNA-templated transcription, initiation
AXE80_05230	COG1215	transferase activity, transferring glycosyl groups
AXE80_05250	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AXE80_05255	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AXE80_05275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AXE80_05295	COG0525	valine-tRNA ligase activity
AXE80_05305	COG0667	Aldo Keto reductase
AXE80_05310	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AXE80_05320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXE80_05325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXE80_05330	COG1253	flavin adenine dinucleotide binding
AXE80_05340	COG2346	COG2346, Truncated hemoglobins
AXE80_05360	COG0116	Belongs to the methyltransferase superfamily
AXE80_05395	COG0653	protein targeting
AXE80_05415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AXE80_05420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AXE80_05430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AXE80_05435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXE80_05445	COG1609	Transcriptional regulator
AXE80_05445	COG2207	Transcriptional regulator
AXE80_05450	COG2814	Major facilitator Superfamily
AXE80_05460	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AXE80_05470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AXE80_05475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AXE80_05485	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AXE80_05505	COG1595	DNA-templated transcription, initiation
AXE80_05530	COG0564	pseudouridine synthase activity
AXE80_05540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AXE80_05540	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AXE80_05585	COG1215	transferase activity, transferring glycosyl groups
AXE80_05595	COG0745	RESPONSE REGULATOR receiver
AXE80_05605	COG4974	Belongs to the 'phage' integrase family
AXE80_05610	COG1917	Cupin 2, conserved barrel domain protein
AXE80_05610	COG4977	sequence-specific DNA binding
AXE80_05615	COG0640	Transcriptional regulator
AXE80_05695	COG0640	Transcriptional regulator
AXE80_05715	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
AXE80_05735	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AXE80_05845	COG0492	ferredoxin-NADP+ reductase activity
AXE80_05865	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_05870	COG0702	epimerase
AXE80_05905	COG5002	protein histidine kinase activity
AXE80_05920	COG4206	TonB-dependent receptor
AXE80_05920	COG1629	transport
AXE80_05955	COG3119	arylsulfatase activity
AXE80_05975	COG3119	arylsulfatase activity
AXE80_05985	COG1629	transport
AXE80_05985	COG4206	TonB-dependent receptor
AXE80_06055	COG1368	sulfuric ester hydrolase activity
AXE80_06080	COG3254	rhamnose metabolic process
AXE80_06110	COG3250	beta-galactosidase activity
AXE80_06130	COG3119	arylsulfatase activity
AXE80_06135	COG3119	arylsulfatase activity
AXE80_06140	COG3119	arylsulfatase activity
AXE80_06155	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_06155	COG3347	Dehydrogenase
AXE80_06160	COG4952	isomerase
AXE80_06165	COG1070	Carbohydrate kinase
AXE80_06170	COG1304	FMN binding
AXE80_06185	COG1858	cytochrome C peroxidase
AXE80_06210	COG2207	Transcriptional regulator
AXE80_06210	COG3708	Transcriptional regulator
AXE80_06215	COG0492	ferredoxin-NADP+ reductase activity
AXE80_06220	COG0463	Glycosyl transferase, family 2
AXE80_06225	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AXE80_06240	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AXE80_06245	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AXE80_06270	COG3119	arylsulfatase activity
AXE80_06275	COG0247	lactate metabolic process
AXE80_06290	COG1346	cytolysis
AXE80_06295	COG0494	nUDIX hydrolase
AXE80_06305	COG1104	cysteine desulfurase activity
AXE80_06310	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AXE80_06325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AXE80_06335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AXE80_06350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AXE80_06355	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AXE80_06365	COG0720	synthase
AXE80_06370	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AXE80_06395	COG1858	cytochrome C peroxidase
AXE80_06410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AXE80_06425	COG0628	permease
AXE80_06435	COG0561	phosphatase activity
AXE80_06445	COG0386	Belongs to the glutathione peroxidase family
AXE80_06450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AXE80_06465	COG2204	response regulator
AXE80_06490	COG0583	DNA-binding transcription factor activity
AXE80_06510	COG0514	ATP-dependent DNA helicase (RecQ)
AXE80_06520	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AXE80_06530	COG1408	metallophosphoesterase
AXE80_06550	COG3012	SEC-C Motif Domain Protein
AXE80_06555	COG1960	acyl-CoA dehydrogenase activity
AXE80_06560	COG0183	Belongs to the thiolase family
AXE80_06565	COG1250	3-hydroxyacyl-CoA dehydrogenase
AXE80_06565	COG1024	Enoyl-CoA hydratase
AXE80_06575	COG4152	abc transporter atp-binding protein
AXE80_06620	COG1979	alcohol dehydrogenase
AXE80_06630	COG1309	transcriptional regulator
AXE80_06640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AXE80_06655	COG1879	ABC-type sugar transport system periplasmic component
AXE80_06665	COG1172	Belongs to the binding-protein-dependent transport system permease family
AXE80_06670	COG0246	Mannitol dehydrogenase
AXE80_06675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXE80_06680	COG1609	Transcriptional regulator
AXE80_06685	COG1629	transport
AXE80_06685	COG4206	TonB-dependent receptor
AXE80_06695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXE80_06700	COG0366	Alpha amylase catalytic
AXE80_06715	COG2885	chlorophyll binding
AXE80_06735	COG1522	sequence-specific DNA binding
AXE80_06755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AXE80_06765	COG0516	GMP reductase activity
AXE80_06765	COG0517	IMP dehydrogenase activity
AXE80_06775	COG1301	dicarboxylic acid transport
AXE80_06820	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AXE80_06825	COG0667	Aldo Keto reductase
AXE80_06830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AXE80_06845	COG1401	restriction endodeoxyribonuclease activity
AXE80_06875	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AXE80_06905	COG0561	phosphatase activity
AXE80_06910	COG4206	TonB-dependent receptor
AXE80_06910	COG1629	transport
AXE80_06915	COG3119	arylsulfatase activity
AXE80_06955	COG1063	alcohol dehydrogenase
AXE80_06960	COG2721	sulfolactate sulfo-lyase activity
AXE80_06965	COG0246	Mannitol dehydrogenase
AXE80_06970	COG3618	amidohydrolase
AXE80_06980	COG0738	Major facilitator superfamily
AXE80_06985	COG3254	rhamnose metabolic process
AXE80_07045	COG0673	inositol 2-dehydrogenase activity
AXE80_07075	COG0513	Belongs to the DEAD box helicase family
AXE80_07135	COG1984	allophanate hydrolase subunit 2
AXE80_07140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AXE80_07145	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AXE80_07175	COG2423	ornithine cyclodeaminase activity
AXE80_07180	COG2827	Endonuclease containing a URI domain
AXE80_07190	COG4974	Belongs to the 'phage' integrase family
AXE80_07200	COG3177	Filamentation induced by cAMP protein fic
AXE80_07250	COG3177	Filamentation induced by cAMP protein fic
AXE80_07330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXE80_07335	COG3119	arylsulfatase activity
AXE80_07340	COG3119	arylsulfatase activity
AXE80_07395	COG4206	TonB-dependent receptor
AXE80_07395	COG1629	transport
AXE80_07400	COG3119	arylsulfatase activity
AXE80_07415	COG3119	arylsulfatase activity
AXE80_07485	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AXE80_07490	COG0497	DNA recombination
AXE80_07515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AXE80_07520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXE80_07530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AXE80_07540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AXE80_07545	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AXE80_07550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AXE80_07555	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AXE80_07560	COG0824	Thioesterase
AXE80_07565	COG1739	Uncharacterized protein family UPF0029
AXE80_07570	COG0697	spore germination
AXE80_07575	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXE80_07575	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXE80_07585	COG2890	protein-(glutamine-N5) methyltransferase activity
AXE80_07590	COG0336	Belongs to the RNA methyltransferase TrmD family
AXE80_07600	COG0335	large ribosomal subunit rRNA binding
AXE80_07660	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_07670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AXE80_07670	COG2207	Transcriptional regulator
AXE80_07685	COG1733	regulation of RNA biosynthetic process
AXE80_07710	COG2267	carboxylic ester hydrolase activity
AXE80_07725	COG1132	(ABC) transporter
AXE80_07745	COG4771	TonB-dependent receptor
AXE80_07760	COG0556	nucleotide-excision repair
AXE80_07765	COG2308	Evidence 4 Homologs of previously reported genes of
AXE80_07765	COG2307	Protein conserved in bacteria
AXE80_07770	COG2308	Evidence 4 Homologs of previously reported genes of
AXE80_07780	COG2307	Protein conserved in bacteria
AXE80_07780	COG2308	Evidence 4 Homologs of previously reported genes of
AXE80_07795	COG2363	Small membrane protein
AXE80_07825	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AXE80_07835	COG3201	nicotinamide mononucleotide transporter
AXE80_07860	COG0408	coproporphyrinogen oxidase activity
AXE80_07865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AXE80_07875	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AXE80_07880	COG0113	porphobilinogen synthase activity
AXE80_07890	COG0181	hydroxymethylbilane synthase activity
AXE80_07895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AXE80_07905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AXE80_07910	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AXE80_07930	COG1904	glucuronate isomerase
AXE80_07935	COG3119	arylsulfatase activity
AXE80_07940	COG5434	Belongs to the glycosyl hydrolase 28 family
AXE80_07945	COG3250	beta-galactosidase activity
AXE80_07950	COG3119	arylsulfatase activity
AXE80_07955	COG3119	arylsulfatase activity
AXE80_07960	COG3119	arylsulfatase activity
AXE80_07965	COG5434	Belongs to the glycosyl hydrolase 28 family
AXE80_07970	COG3119	arylsulfatase activity
AXE80_07980	COG3250	beta-galactosidase activity
AXE80_07985	COG3119	arylsulfatase activity
AXE80_08005	COG3250	beta-galactosidase activity
AXE80_08015	COG3119	arylsulfatase activity
AXE80_08025	COG3119	arylsulfatase activity
AXE80_08030	COG3119	arylsulfatase activity
AXE80_08035	COG3119	arylsulfatase activity
AXE80_08060	COG5434	Belongs to the glycosyl hydrolase 28 family
AXE80_08070	COG0445	tRNA wobble uridine modification
AXE80_08075	COG3119	arylsulfatase activity
AXE80_08120	COG4206	TonB-dependent receptor
AXE80_08120	COG1629	transport
AXE80_08125	COG5002	protein histidine kinase activity
AXE80_08135	COG3250	beta-galactosidase activity
AXE80_08170	COG1196	nuclear chromosome segregation
AXE80_08175	COG3421	Type III restriction
AXE80_08185	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AXE80_08195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXE80_08205	COG2135	peptidase activity
AXE80_08235	COG4974	Belongs to the 'phage' integrase family
AXE80_08245	COG3118	belongs to the thioredoxin family
AXE80_08250	COG1410	methionine synthase
AXE80_08250	COG0646	methionine synthase
AXE80_08255	COG0646	methionine synthase
AXE80_08255	COG1410	methionine synthase
AXE80_08265	COG1472	Belongs to the glycosyl hydrolase 3 family
AXE80_08285	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AXE80_08305	COG0069	glutamate synthase activity
AXE80_08305	COG0067	glutamate synthase
AXE80_08305	COG0070	glutamate synthase
AXE80_08335	COG0514	ATP-dependent DNA helicase (RecQ)
AXE80_08345	COG0805	protein transport
AXE80_08350	COG1137	ATPase activity
AXE80_08370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AXE80_08395	COG0438	transferase activity, transferring glycosyl groups
AXE80_08425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AXE80_08435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AXE80_08440	COG1083	cytidylyl-transferase
AXE80_08445	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AXE80_08450	COG2089	acid synthase
AXE80_08460	COG0463	Glycosyl transferase, family 2
AXE80_08465	COG1442	glycosyl transferase family 8
AXE80_08465	COG1216	Glycosyl transferase, family 2
AXE80_08470	COG3274	enterobacterial common antigen metabolic process
AXE80_08475	COG0438	transferase activity, transferring glycosyl groups
AXE80_08480	COG1216	Glycosyl transferase, family 2
AXE80_08485	COG0463	Glycosyl transferase, family 2
AXE80_08490	COG0438	transferase activity, transferring glycosyl groups
AXE80_08510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AXE80_08515	COG4974	Belongs to the 'phage' integrase family
AXE80_08520	COG1418	mRNA catabolic process
AXE80_08560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AXE80_08565	COG2827	Endonuclease containing a URI domain
AXE80_08585	COG1278	Cold shock
AXE80_08590	COG0738	Major facilitator superfamily
AXE80_08600	COG0716	FMN binding
AXE80_08635	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AXE80_08655	COG0450	alkyl hydroperoxide reductase
AXE80_08670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AXE80_08675	COG0569	domain protein
AXE80_08685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AXE80_08715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AXE80_08735	COG3011	Protein conserved in bacteria
AXE80_08765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AXE80_08775	COG0259	pyridoxamine-phosphate oxidase activity
AXE80_08790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AXE80_08795	COG0483	inositol monophosphate 1-phosphatase activity
AXE80_08805	COG0527	aspartate kinase activity
AXE80_08820	COG0673	inositol 2-dehydrogenase activity
AXE80_08825	COG0644	oxidoreductase
AXE80_08830	COG1333	cytochrome c biogenesis protein
AXE80_08830	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AXE80_08840	COG0438	transferase activity, transferring glycosyl groups
AXE80_08875	COG1629	transport
AXE80_08875	COG4206	TonB-dependent receptor
AXE80_08905	COG0745	RESPONSE REGULATOR receiver
AXE80_08910	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AXE80_08915	COG1070	Carbohydrate kinase
AXE80_08925	COG0235	Class ii aldolase
AXE80_08930	COG2207	Transcriptional regulator
AXE80_08930	COG1917	Cupin 2, conserved barrel domain protein
AXE80_08940	COG1012	belongs to the aldehyde dehydrogenase family
AXE80_08945	COG0738	Major facilitator superfamily
AXE80_08950	COG1304	FMN binding
AXE80_08960	COG0174	glutamine synthetase
AXE80_08965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AXE80_08970	COG1663	tetraacyldisaccharide 4'-kinase activity
AXE80_08975	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AXE80_08990	COG1278	Cold shock
AXE80_08995	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AXE80_09000	COG0195	Participates in both transcription termination and antitermination
AXE80_09005	COG0779	Required for maturation of 30S ribosomal subunits
AXE80_09020	COG0726	polysaccharide deacetylase
AXE80_09025	COG3118	belongs to the thioredoxin family
AXE80_09030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXE80_09030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXE80_09035	COG1368	sulfuric ester hydrolase activity
AXE80_09040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AXE80_09045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AXE80_09050	COG0052	Belongs to the universal ribosomal protein uS2 family
AXE80_09055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AXE80_09060	COG0528	UMP kinase activity
AXE80_09065	COG0233	cytoplasmic translational termination
AXE80_09075	COG0659	secondary active sulfate transmembrane transporter activity
AXE80_09120	COG0415	Belongs to the DNA photolyase family
AXE80_09135	COG0432	Pfam Uncharacterised protein family UPF0047
AXE80_09140	COG0071	Belongs to the small heat shock protein (HSP20) family
AXE80_09150	COG0443	Heat shock 70 kDa protein
AXE80_09160	COG3022	response to hydroperoxide
AXE80_09165	COG0564	pseudouridine synthase activity
AXE80_09175	COG1181	Belongs to the D-alanine--D-alanine ligase family
AXE80_09180	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AXE80_09210	COG1132	(ABC) transporter
AXE80_09245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AXE80_09260	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AXE80_09290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AXE80_09295	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AXE80_09300	COG2115	Belongs to the xylose isomerase family
AXE80_09305	COG1070	Carbohydrate kinase
AXE80_09335	COG0564	pseudouridine synthase activity
AXE80_09365	COG4206	TonB-dependent receptor
AXE80_09365	COG1629	transport
AXE80_09380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AXE80_09380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXE80_09400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AXE80_09410	COG0561	phosphatase activity
AXE80_09425	COG0542	response to heat
AXE80_09435	COG0450	alkyl hydroperoxide reductase
AXE80_09455	COG0488	(ABC) transporter
AXE80_09460	COG2223	nitrite transmembrane transporter activity
AXE80_09465	COG0778	Nitroreductase
AXE80_09475	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AXE80_09485	COG0424	maF-like protein
AXE80_09490	COG3958	Transketolase
AXE80_09495	COG0783	Belongs to the Dps family
AXE80_09500	COG0583	DNA-binding transcription factor activity
AXE80_09505	COG1022	Amp-dependent synthetase and ligase
AXE80_09515	COG0101	tRNA pseudouridine synthase activity
AXE80_09520	COG1132	(ABC) transporter
AXE80_09525	COG0251	oxidation-reduction process
AXE80_09530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AXE80_09535	COG1803	Methylglyoxal synthase
AXE80_09545	COG0205	6-phosphofructokinase activity
AXE80_09560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AXE80_09580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AXE80_09595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AXE80_09600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AXE80_09605	COG2095	MarC family integral membrane protein
AXE80_09635	COG3123	guanosine phosphorylase activity
AXE80_09645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AXE80_09675	COG0437	4 iron, 4 sulfur cluster binding
AXE80_09690	COG2197	response regulator
AXE80_09695	COG0488	(ABC) transporter
AXE80_09725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AXE80_09730	COG0217	transcriptional regulatory protein
AXE80_09770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AXE80_09795	COG0670	Belongs to the BI1 family
AXE80_09810	COG2197	response regulator
AXE80_09820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AXE80_09825	COG3290	protein histidine kinase activity
AXE80_09830	COG2755	lipolytic protein G-D-S-L family
AXE80_09830	COG0657	acetylesterase activity
AXE80_09835	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AXE80_09840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AXE80_09855	COG1160	GTP binding
AXE80_09865	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AXE80_09865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AXE80_09900	COG1595	DNA-templated transcription, initiation
AXE80_09905	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AXE80_09910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AXE80_09915	COG1045	serine acetyltransferase
AXE80_09930	COG2095	MarC family integral membrane protein
AXE80_09955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AXE80_09975	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AXE80_09980	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AXE80_09995	COG0753	catalase activity
AXE80_10000	COG0579	oxidoreductase
AXE80_10005	COG5492	domain, Protein
AXE80_10015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXE80_10025	COG0343	queuine tRNA-ribosyltransferase activity
AXE80_10065	COG3119	arylsulfatase activity
AXE80_10105	COG0612	Peptidase, M16
AXE80_10115	COG1012	belongs to the aldehyde dehydrogenase family
AXE80_10120	COG4948	Mandelate Racemase Muconate Lactonizing
AXE80_10135	COG4206	TonB-dependent receptor
AXE80_10135	COG1629	transport
AXE80_10140	COG3119	arylsulfatase activity
AXE80_10160	COG3734	2-keto-3-deoxy-galactonokinase
AXE80_10165	COG0800	Aldolase
AXE80_10170	COG2207	Transcriptional regulator
AXE80_10175	COG3119	arylsulfatase activity
AXE80_10195	COG2814	Major facilitator Superfamily
AXE80_10205	COG0445	tRNA wobble uridine modification
AXE80_10225	COG3119	arylsulfatase activity
AXE80_10235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AXE80_10240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AXE80_10260	COG1999	signal sequence binding
AXE80_10265	COG0210	DNA helicase
AXE80_10270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXE80_10275	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AXE80_10320	COG3693	PFAM glycoside hydrolase, family 10
AXE80_10330	COG3119	arylsulfatase activity
AXE80_10345	COG1629	transport
AXE80_10345	COG4206	TonB-dependent receptor
AXE80_10360	COG1959	2 iron, 2 sulfur cluster binding
AXE80_10375	COG3119	arylsulfatase activity
AXE80_10420	COG0561	phosphatase activity
AXE80_10425	COG1629	transport
AXE80_10425	COG4206	TonB-dependent receptor
AXE80_10435	COG0673	inositol 2-dehydrogenase activity
AXE80_10460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXE80_10465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AXE80_10485	COG1266	CAAX protease self-immunity
AXE80_10490	COG4948	Mandelate Racemase Muconate Lactonizing
AXE80_10505	COG1575	Belongs to the MenA family. Type 1 subfamily
AXE80_10510	COG0247	lactate metabolic process
AXE80_10510	COG2181	nitrate reductase activity
AXE80_10515	COG2181	nitrate reductase activity
AXE80_10515	COG0247	lactate metabolic process
AXE80_10535	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AXE80_10565	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
AXE80_10575	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AXE80_10605	COG0012	GTP binding
AXE80_10615	COG1312	Catalyzes the dehydration of D-mannonate
AXE80_10625	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_10630	COG2171	N-acyltransferase activity
AXE80_10635	COG2957	Belongs to the agmatine deiminase family
AXE80_10650	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AXE80_10655	COG0513	Belongs to the DEAD box helicase family
AXE80_10665	COG0513	Belongs to the DEAD box helicase family
AXE80_10685	COG0463	Glycosyl transferase, family 2
AXE80_10690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXE80_10695	COG1132	(ABC) transporter
AXE80_10700	COG1193	negative regulation of DNA recombination
AXE80_10710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AXE80_10725	COG2197	response regulator
AXE80_10825	COG3392	D12 class N6 adenine-specific DNA methyltransferase
AXE80_10920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AXE80_10925	COG1764	response to oxidative stress
AXE80_10945	COG1012	belongs to the aldehyde dehydrogenase family
AXE80_10950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AXE80_10955	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AXE80_10970	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AXE80_10970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AXE80_10975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AXE80_10985	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AXE80_11005	COG0516	GMP reductase activity
AXE80_11010	COG1573	uracil-dna glycosylase
AXE80_11015	COG4977	sequence-specific DNA binding
AXE80_11035	COG1902	pentaerythritol trinitrate reductase activity
AXE80_11040	COG0825	malonyl-CoA metabolic process
AXE80_11050	COG1187	pseudouridine synthase activity
AXE80_11075	COG2081	HI0933 family
AXE80_11105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXE80_11115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXE80_11130	COG0514	ATP-dependent DNA helicase (RecQ)
AXE80_11135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AXE80_11140	COG0776	regulation of translation
AXE80_11145	COG1678	Uncharacterized ACR, COG1678
AXE80_11165	COG1363	Peptidase, m42
AXE80_11170	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AXE80_11180	COG2271	Major facilitator Superfamily
AXE80_11185	COG2186	Transcriptional regulator
AXE80_11210	COG4206	TonB-dependent receptor
AXE80_11210	COG1629	transport
AXE80_11215	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_11235	COG0617	tRNA 3'-terminal CCA addition
AXE80_11240	COG0009	L-threonylcarbamoyladenylate synthase
AXE80_11255	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AXE80_11295	COG0438	transferase activity, transferring glycosyl groups
AXE80_11305	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AXE80_11325	COG1091	dTDP-4-dehydrorhamnose reductase activity
AXE80_11330	COG1088	dTDP-glucose 4,6-dehydratase activity
AXE80_11335	COG0242	peptide deformylase activity
AXE80_11345	COG3956	TIGRFAM MazG family protein
AXE80_11360	COG1607	acyl-coa hydrolase
AXE80_11365	COG0505	Belongs to the CarA family
AXE80_11370	COG0203	ribosomal protein L17
AXE80_11375	COG0202	RNA polymerase activity
AXE80_11380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AXE80_11385	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AXE80_11390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AXE80_11395	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AXE80_11400	COG0201	protein transport
AXE80_11405	COG0200	Binds to the 23S rRNA
AXE80_11410	COG1841	ribosomal large subunit assembly
AXE80_11415	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AXE80_11425	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AXE80_11430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AXE80_11435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AXE80_11440	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AXE80_11445	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AXE80_11450	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AXE80_11455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AXE80_11460	COG0255	Belongs to the universal ribosomal protein uL29 family
AXE80_11465	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AXE80_11470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AXE80_11475	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AXE80_11480	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AXE80_11485	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AXE80_11490	COG0089	rRNA binding
AXE80_11495	COG0088	Forms part of the polypeptide exit tunnel
AXE80_11500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AXE80_11505	COG0051	transcription antitermination factor activity, RNA binding
AXE80_11510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AXE80_11515	COG0049	tRNA binding
AXE80_11520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AXE80_11535	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AXE80_11540	COG2226	methyltransferase
AXE80_11545	COG3119	arylsulfatase activity
AXE80_11550	COG3119	arylsulfatase activity
AXE80_11570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXE80_11605	COG0148	phosphopyruvate hydratase activity
AXE80_11615	COG0848	biopolymer transport protein
AXE80_11625	COG0811	peptide transport
AXE80_11630	COG0252	asparaginase activity
AXE80_11635	COG0439	Biotin carboxylase
AXE80_11640	COG0511	ligase activity, forming carbon-carbon bonds
AXE80_11645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AXE80_11650	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AXE80_11660	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AXE80_11665	COG0307	riboflavin synthase, alpha
AXE80_11675	COG0463	Glycosyl transferase, family 2
AXE80_11710	COG3279	Response regulator of the LytR AlgR family
AXE80_11720	COG5002	protein histidine kinase activity
AXE80_11730	COG4251	negative regulation of phosphorylation
AXE80_11740	COG0784	Response regulator, receiver
AXE80_11770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AXE80_11800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AXE80_11805	COG1968	undecaprenyl-diphosphatase activity
AXE80_11815	COG2177	Part of the ABC transporter FtsEX involved in
AXE80_11820	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AXE80_11830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AXE80_11845	COG3254	rhamnose metabolic process
AXE80_11850	COG0738	Major facilitator superfamily
AXE80_11855	COG3618	amidohydrolase
AXE80_11860	COG0800	Aldolase
AXE80_11870	COG1063	alcohol dehydrogenase
AXE80_11875	COG1609	Transcriptional regulator
AXE80_11885	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AXE80_11915	COG0791	NLP P60 protein
AXE80_11925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AXE80_11935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AXE80_11940	COG0542	response to heat
AXE80_11955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXE80_11995	COG1506	peptidase
AXE80_11995	COG0823	Involved in the tonB-independent uptake of proteins
AXE80_12005	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AXE80_12010	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AXE80_12035	COG2967	ApaG domain
AXE80_12065	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AXE80_12090	COG2166	iron-sulfur cluster assembly
AXE80_12095	COG2151	metal-sulfur cluster biosynthetic enzyme
AXE80_12115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AXE80_12135	COG0473	3-isopropylmalate dehydrogenase activity
AXE80_12140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXE80_12150	COG0066	3-isopropylmalate dehydratase activity
AXE80_12155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AXE80_12170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AXE80_12190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AXE80_12200	COG0194	GDP metabolic process
AXE80_12215	COG0791	NLP P60 protein
AXE80_12230	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AXE80_12245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AXE80_12250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AXE80_12255	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AXE80_12265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AXE80_12280	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AXE80_12280	COG0352	thiamine-phosphate diphosphorylase activity
AXE80_12280	COG0351	phosphomethylpyrimidine kinase
AXE80_12290	COG0352	thiamine-phosphate diphosphorylase activity
AXE80_12305	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AXE80_12320	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AXE80_12340	COG0471	metal ion transport
AXE80_12350	COG0187	DNA topoisomerase II activity
AXE80_12365	COG0039	L-malate dehydrogenase activity
AXE80_12380	COG0569	domain protein
AXE80_12385	COG2003	Belongs to the UPF0758 family
AXE80_12400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AXE80_12415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AXE80_12425	COG0024	Methionine aminopeptidase
AXE80_12430	COG0671	phosphoesterase, PA-phosphatase related
AXE80_12435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AXE80_12440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXE80_12450	COG0101	tRNA pseudouridine synthase activity
AXE80_12455	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AXE80_12460	COG1185	polyribonucleotide nucleotidyltransferase activity
AXE80_12480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AXE80_12485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AXE80_12490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AXE80_12525	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AXE80_12540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXE80_12545	COG3604	Transcriptional regulator
AXE80_12565	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AXE80_12570	COG0459	protein refolding
AXE80_12585	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AXE80_12590	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AXE80_12600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AXE80_12630	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AXE80_12635	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AXE80_12650	COG1085	galactose-1-phosphate uridylyltransferase
AXE80_12655	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AXE80_12665	COG1725	Transcriptional regulator
AXE80_12675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AXE80_12680	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AXE80_12685	COG0193	aminoacyl-tRNA hydrolase activity
AXE80_12690	COG3119	arylsulfatase activity
AXE80_12695	COG0720	synthase
AXE80_12740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AXE80_12745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AXE80_12750	COG1121	(ABC) transporter
AXE80_12755	COG0803	Belongs to the bacterial solute-binding protein 9 family
AXE80_12765	COG4771	TonB-dependent receptor
AXE80_12775	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AXE80_12795	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AXE80_12820	COG3530	Putative quorum-sensing-regulated virulence factor
AXE80_12825	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AXE80_12835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AXE80_12845	COG1538	Outer membrane efflux protein
AXE80_12855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXE80_12865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXE80_12875	COG0563	adenylate kinase activity
AXE80_12880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AXE80_12885	COG0745	RESPONSE REGULATOR receiver
AXE80_12890	COG5002	protein histidine kinase activity
AXE80_12905	COG4585	Histidine kinase
AXE80_12925	COG2197	response regulator
AXE80_12930	COG0606	chelatase, subunit chli
AXE80_12945	COG0544	peptidyl-prolyl cis-trans isomerase activity
AXE80_12950	COG0596	Alpha beta hydrolase
AXE80_12955	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AXE80_12965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AXE80_12975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AXE80_13000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AXE80_13020	COG2226	methyltransferase
AXE80_13025	COG1477	protein flavinylation
AXE80_13035	COG2226	methyltransferase
AXE80_13045	COG3842	ATPase activity
AXE80_13060	COG1360	Flagellar Motor Protein
AXE80_13065	COG0708	Exodeoxyribonuclease III
AXE80_13070	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AXE80_13080	COG1774	PSP1 C-terminal conserved region
AXE80_13105	COG0509	glycine decarboxylation via glycine cleavage system
AXE80_13115	COG0632	four-way junction helicase activity
AXE80_13130	COG1519	Transferase
AXE80_13145	COG0166	Belongs to the GPI family
AXE80_13165	COG0571	ribonuclease III activity
AXE80_13170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AXE80_13175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AXE80_13180	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AXE80_13185	COG0328	RNA-DNA hybrid ribonuclease activity
AXE80_13185	COG3341	Caulimovirus viroplasmin
AXE80_13205	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AXE80_13210	COG0322	excinuclease ABC activity
AXE80_13215	COG1752	Esterase of the alpha-beta hydrolase superfamily
AXE80_13225	COG1530	ribonuclease E activity
AXE80_13230	COG0776	regulation of translation
AXE80_13240	COG0629	single-stranded DNA binding
AXE80_13270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AXE80_13275	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AXE80_13280	COG0719	Fe-S assembly protein
AXE80_13285	COG0396	ATPase activity
AXE80_13295	COG0719	Fe-S assembly protein
AXE80_13300	COG0316	Belongs to the HesB IscA family
AXE80_13305	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AXE80_13325	COG0745	RESPONSE REGULATOR receiver
AXE80_13330	COG5002	protein histidine kinase activity
AXE80_13335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AXE80_13345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AXE80_13355	COG0594	ribonuclease P activity
AXE80_13365	COG1381	Involved in DNA repair and RecF pathway recombination
AXE80_13380	COG1272	protein, Hemolysin III
AXE80_13385	COG0180	Tryptophanyl-tRNA synthetase
AXE80_13395	COG3250	beta-galactosidase activity
AXE80_13415	COG2124	cytochrome p450
AXE80_13420	COG1917	Cupin 2, conserved barrel domain protein
AXE80_13420	COG2207	Transcriptional regulator
AXE80_13425	COG0667	Aldo Keto reductase
AXE80_13430	COG0126	phosphoglycerate kinase activity
AXE80_13435	COG0470	DNA polymerase III
AXE80_13440	COG5002	protein histidine kinase activity
AXE80_13455	COG1595	DNA-templated transcription, initiation
AXE80_13475	COG2972	Histidine kinase
AXE80_13475	COG0745	RESPONSE REGULATOR receiver
AXE80_13480	COG3279	Response regulator of the LytR AlgR family
AXE80_13485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AXE80_13490	COG0445	tRNA wobble uridine modification
AXE80_13495	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AXE80_13500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXE80_13520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AXE80_13530	COG0557	exoribonuclease II activity
AXE80_13540	COG0698	ribose 5-phosphate isomerase
AXE80_13550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AXE80_13560	COG0793	Belongs to the peptidase S41A family
AXE80_13565	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXE80_13570	COG1472	Belongs to the glycosyl hydrolase 3 family
AXE80_13575	COG0714	Associated with various cellular activities
AXE80_13595	COG2304	oxidoreductase activity
AXE80_13620	COG0668	transmembrane transport
AXE80_13660	COG0792	nuclease activity
AXE80_13665	COG1619	proteins homologs of microcin C7 resistance protein MccF
AXE80_13670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXE80_13670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXE80_13685	COG4109	DRTGG domain
AXE80_13695	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AXE80_13710	COG0006	proline dipeptidase activity
AXE80_13725	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AXE80_13735	COG1119	ATPase activity
AXE80_13740	COG2721	sulfolactate sulfo-lyase activity
AXE80_13745	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_13750	COG0179	Fumarylacetoacetate (FAA) hydrolase
AXE80_13755	COG1304	FMN binding
AXE80_13760	COG0629	single-stranded DNA binding
AXE80_13800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AXE80_13815	COG1053	succinate dehydrogenase
AXE80_13820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AXE80_13825	COG2045	Belongs to the ComB family
AXE80_13830	COG0084	hydrolase, TatD family'
AXE80_13835	COG0038	chloride channel
AXE80_13855	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AXE80_13860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AXE80_13870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AXE80_13880	COG3852	Histidine kinase
AXE80_13895	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AXE80_13935	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AXE80_13950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXE80_13960	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AXE80_13965	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AXE80_13985	COG3769	mannosylglycerate metabolic process
AXE80_13990	COG2379	hydroxypyruvate reductase
AXE80_13995	COG1215	transferase activity, transferring glycosyl groups
AXE80_14000	COG0366	Alpha amylase catalytic
AXE80_14005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXE80_14040	COG0356	it plays a direct role in the translocation of protons across the membrane
AXE80_14045	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXE80_14050	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AXE80_14055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXE80_14060	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AXE80_14065	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AXE80_14085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AXE80_14130	COG0489	protein tyrosine kinase activity
AXE80_14140	COG0488	(ABC) transporter
AXE80_14180	COG0758	DNA mediated transformation
AXE80_14180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AXE80_14190	COG0756	dUTP diphosphatase activity