locus-tag	class	description
WM2015_1	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
WM2015_10	ENOG4105CY0	Metallo-Beta-Lactamase
WM2015_1002	ENOG4105BZS	acriflavin resistance protein
WM2015_1005	ENOG4105ETX	regulatoR
WM2015_1006	ENOG4105E27	serine threonine protein kinase
WM2015_101	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
WM2015_1010	ENOG4107QRT	dEAD DEAH box helicase
WM2015_1011	ENOG4107QIM	DNA ligase
WM2015_1014	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
WM2015_1017	ENOG4105JHY	Membrane
WM2015_1022	ENOG4105CJW	magnesium transporter
WM2015_103	ENOG4105CHM	Aminotransferase
WM2015_1031	ENOG4105BZ8	glutamate synthase
WM2015_1032	ENOG4105CBC	glutamate synthase
WM2015_1033	ENOG4105CVB	Vitamin K epoxide reductase
WM2015_1037	ENOG4105CAY	ferredoxin--nadp reductase
WM2015_1038	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
WM2015_104	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
WM2015_1040	ENOG4105D0A	hydroxylase
WM2015_1041	ENOG4105D0A	hydroxylase
WM2015_1042	ENOG4107RAQ	aminopeptidase
WM2015_1045	ENOG410687F	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
WM2015_1046	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
WM2015_1048	ENOG4105E66	phosphoriboisomerase A
WM2015_105	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
WM2015_1050	ENOG4105BZU	Histidine kinase
WM2015_1051	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
WM2015_1052	ENOG4105CIK	Amidinotransferase
WM2015_1054	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
WM2015_1055	ENOG4105IFJ	Histidine kinase
WM2015_1056	ENOG4105DXN	mazG family
WM2015_1058	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
WM2015_106	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
WM2015_1061	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
WM2015_1065	ENOG4105BZM	domain protein
WM2015_1067	ENOG4105D9P	serine threonine protein kinase
WM2015_1071	ENOG4108V1T	peptidylprolyl cis-trans isomerase
WM2015_1081	ENOG4105E6M	Sulphatase-modifying factor protein
WM2015_1090	ENOG4108UKI	Enoyl-CoA hydratase
WM2015_1091	ENOG4107QX3	carboxylase
WM2015_1093	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
WM2015_1094	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
WM2015_1097	ENOG4105DKP	glycosyl transferase, family 9
WM2015_1099	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
WM2015_11	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
WM2015_1102	ENOG4108PCN	EamA-like transporter family
WM2015_1104	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
WM2015_1105	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WM2015_1106	ENOG4105CDV	Ompa motb domain protein
WM2015_1107	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
WM2015_1108	ENOG4105C8N	cysteinyl-tRNA synthetase
WM2015_1109	ENOG4105D9Y	Splits dipeptides with a prolyl residue in the C- terminal position (By similarity)
WM2015_1111	ENOG4108UQY	Iron-storage protein
WM2015_1113	ENOG4105CPI	Metal Dependent Phosphohydrolase
WM2015_1115	ENOG4108I0Z	Aconitate hydratase
WM2015_1116	ENOG4105C7F	AcnD-accessory protein PrpF
WM2015_112	ENOG4105CI2	imidazolone-5-propionate hydrolase
WM2015_1121	ENOG4108MR6	WD40-like Beta Propeller Repeat
WM2015_1128	ENOG4105CS1	NAD(P)H quinone oxidoreductase
WM2015_1129	ENOG4105CC0	LysR family Transcriptional regulator
WM2015_1131	ENOG4108KTG	Membrane protein, drug metabolite transporter
WM2015_1137	ENOG4107QIJ	Aconitate hydratase 2
WM2015_1139	ENOG4105NA0	Transcriptional regulator
WM2015_114	ENOG4105KDC	50s ribosomal protein l28
WM2015_115	ENOG4105W0E	50S ribosomal protein L33
WM2015_1152	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
WM2015_1154	ENOG4105CBG	Sulfatase
WM2015_116	ENOG4105W5Q	DNA repair protein (RadC
WM2015_1162	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
WM2015_1167	ENOG4105D9P	serine threonine protein kinase
WM2015_117	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
WM2015_1175	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
WM2015_118	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
WM2015_119	ENOG4107QKV	phosphomannomutase
WM2015_1196	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
WM2015_120	ENOG4108R99	pseudouridine synthase
WM2015_1203	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
WM2015_1207	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
WM2015_1211	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
WM2015_1212	ENOG4105EJ2	Transcriptional regulator
WM2015_1213	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
WM2015_122	ENOG4107QSI	ABC, transporter
WM2015_1222	ENOG4105BZU	Histidine kinase
WM2015_1223	ENOG4105FUQ	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
WM2015_123	ENOG4107QSI	ABC, transporter
WM2015_1230	ENOG4105C1G	acyl-Coa dehydrogenase
WM2015_1235	ENOG41080HT	Transcriptional regulator, arsr family
WM2015_1236	ENOG4105D5P	Methylmalonyl-coA mutase
WM2015_1239	ENOG4105DUX	Transporter
WM2015_124	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
WM2015_1240	ENOG4105C0B	DNA polymerase III (alpha subunit)
WM2015_1248	ENOG4108TQ9	Histidine kinase
WM2015_1249	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
WM2015_125	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
WM2015_1253	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
WM2015_1257	ENOG4105D9P	serine threonine protein kinase
WM2015_126	ENOG4105PGM	cation diffusion facilitator family transporter
WM2015_1262	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
WM2015_1263	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
WM2015_1264	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
WM2015_1266	ENOG4105K70	DNA-binding protein
WM2015_1267	ENOG4105EIN	peptidylprolyl cis-trans isomerase
WM2015_1268	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
WM2015_1269	ENOG4108YYH	Nadph-dependent fmn reductase
WM2015_127	ENOG4105C3U	ABC transporter
WM2015_1271	ENOG4105E6M	Sulphatase-modifying factor protein
WM2015_1272	ENOG4108NST	exported protein
WM2015_1274	ENOG4105DWV	Homoserine O-trans-acetylase
WM2015_1275	ENOG4105EIF	outer membrane protein W
WM2015_1276	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
WM2015_1277	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
WM2015_128	ENOG4108JQ7	(ABC) transporter
WM2015_1280	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
WM2015_1282	ENOG4105C8Y	Acetylornithine aminotransferase
WM2015_1283	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
WM2015_1287	ENOG4105CSM	endonuclease III
WM2015_1293	ENOG4108R3D	Electron transport complex
WM2015_1296	ENOG4105DGN	Electron transport complex
WM2015_1297	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
WM2015_1298	ENOG4105D1F	ATP-binding protein
WM2015_130	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
WM2015_1300	ENOG4105C0H	protease
WM2015_1302	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
WM2015_1303	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
WM2015_1304	ENOG4105EIX	cytochrome c1
WM2015_1305	ENOG4107MKT	Stringent starvation protein a
WM2015_1306	ENOG4105KB2	stringent starvation protein b
WM2015_1309	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
WM2015_131	ENOG4107QJE	Chromosome Partitioning Protein
WM2015_1310	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
WM2015_1311	ENOG4108UM1	dedA family
WM2015_1312	ENOG4108K5P	(LipO)protein
WM2015_1314	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
WM2015_1315	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
WM2015_1316	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
WM2015_1317	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
WM2015_1318	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
WM2015_1319	ENOG4107QJR	hflk protein
WM2015_132	ENOG4105FA0	parb-like partition protein
WM2015_1320	ENOG4105EPW	hflc protein
WM2015_1321	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
WM2015_1322	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
WM2015_1323	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
WM2015_1325	ENOG4105CIH	Imidazole acetol-phosphate transaminase
WM2015_1326	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
WM2015_1327	ENOG4105CAT	Cytidine monophosphate kinase
WM2015_1328	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
WM2015_1329	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
WM2015_133	ENOG4108HWS	Histidine kinase
WM2015_1331	ENOG4105CFV	Tetratricopeptide repeat protein
WM2015_1335	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
WM2015_1337	ENOG4106RE7	Cytochrome
WM2015_1338	ENOG4105C1G	acyl-Coa dehydrogenase
WM2015_1340	ENOG41066DG	(EAL) domain protein
WM2015_1341	ENOG4107RN6	Monooxygenase
WM2015_1343	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
WM2015_1344	ENOG4105CPQ	Dehydrogenase
WM2015_1345	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
WM2015_1346	ENOG4105C7K	acetolactate synthase
WM2015_1348	ENOG4105E51	psp operon transcriptional activator
WM2015_1349	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
WM2015_135	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
WM2015_1351	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
WM2015_1352	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
WM2015_1353	ENOG4105D64	Mechanosensitive ion channel
WM2015_1355	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
WM2015_136	ENOG4107RBB	ABC transporter, permease
WM2015_1360	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
WM2015_1361	ENOG4107TH8	cina domain protein
WM2015_1362	ENOG4108784	2'-5' rna ligase
WM2015_1363	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
WM2015_1364	ENOG4105Y3E	Modulates RecA activity (By similarity)
WM2015_1365	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
WM2015_1366	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
WM2015_1367	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
WM2015_1368	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
WM2015_1369	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
WM2015_137	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
WM2015_1370	ENOG4108Z6B	deaminase
WM2015_1371	ENOG4105DGW	oligopeptidase A
WM2015_1373	ENOG4105C1G	acyl-Coa dehydrogenase
WM2015_1374	ENOG4105C7I	Dehydrogenase
WM2015_1375	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
WM2015_1378	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
WM2015_1381	ENOG4105BZU	Histidine kinase
WM2015_1382	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
WM2015_1383	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
WM2015_1386	ENOG4108M8H	domain protein
WM2015_1389	ENOG4105C9K	Endothelin-converting enzyme 1
WM2015_1390	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
WM2015_1391	ENOG4105M3Z	response regulator
WM2015_1393	ENOG4105CK7	Sodium proline symporter
WM2015_1394	ENOG4108JJ8	(ABC) transporter
WM2015_1395	ENOG4108JJ9	ABC, transporter
WM2015_1396	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
WM2015_1397	ENOG4105C4M	(Ubiquinol oxidase) subunit I
WM2015_140	ENOG4108IXY	short-chain dehydrogenase reductase
WM2015_1400	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
WM2015_1401	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
WM2015_1402	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
WM2015_1403	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
WM2015_1407	ENOG4105EW9	transcriptional regulator AsnC family
WM2015_1408	ENOG4107QM5	aconitate hydratase
WM2015_1412	ENOG4105D9P	serine threonine protein kinase
WM2015_1413	ENOG41075W9	High frequency lysogenization protein HflD homolog
WM2015_1414	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
WM2015_1415	ENOG4107R11	Transcriptional regulator
WM2015_1416	ENOG4107QP3	malate synthase g
WM2015_1418	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
WM2015_1419	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
WM2015_142	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
WM2015_1420	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
WM2015_1421	ENOG4108VDT	Glycosyl transferase family protein
WM2015_1423	ENOG4105D9P	serine threonine protein kinase
WM2015_1424	ENOG4105CEU	Arginine dihydrolase
WM2015_1425	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
WM2015_1428	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
WM2015_1429	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
WM2015_143	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
WM2015_1430	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
WM2015_1431	ENOG4105C9Q	fumarate hydratase class II
WM2015_1432	ENOG4108RRZ	Transcription elongation factor GreB
WM2015_1433	ENOG4108ZNX	Heat shock protein
WM2015_1438	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
WM2015_144	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
WM2015_1440	ENOG4105C3M	thioredoxin reductase
WM2015_1441	ENOG4105DCF	alanine dehydrogenase
WM2015_1442	ENOG4105CNU	cell division protein FtsK
WM2015_1443	ENOG4107TMZ	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
WM2015_1449	ENOG4105BZ1	(ABC) transporter
WM2015_145	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
WM2015_1453	ENOG4105WH1	Two component transcriptional regulator luxr family
WM2015_146	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
WM2015_1460	ENOG4105VS7	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity)
WM2015_1461	ENOG4105C3W	Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity)
WM2015_1465	ENOG4105C5S	asparaginyl-tRNA synthetase
WM2015_1466	ENOG4108Z4V	iron-sulfur cluster assembly
WM2015_1468	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
WM2015_1469	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
WM2015_147	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
WM2015_1470	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
WM2015_1471	ENOG4105CDU	Replicative dna helicase
WM2015_1472	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
WM2015_1473	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
WM2015_1474	ENOG4105C9A	Phoh family
WM2015_1475	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
WM2015_1476	ENOG4108JU5	Magnesium and cobalt efflux protein
WM2015_148	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
WM2015_1482	ENOG4105DQ4	alcohol dehydrogenase
WM2015_1485	ENOG4108IQE	Amp-dependent synthetase and ligase
WM2015_1487	ENOG4105CH2	amidohydrolase
WM2015_149	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
WM2015_1493	ENOG4107RY6	amino acid
WM2015_1497	ENOG4105C5H	ABC transporter
WM2015_15	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
WM2015_150	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
WM2015_1501	ENOG4108M3R	transcriptional activator CadC
WM2015_1503	ENOG4108JA2	transcriptioN-repair coupling factor
WM2015_1505	ENOG4108YZY	peptidylprolyl cis-trans isomerase
WM2015_1506	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
WM2015_1507	ENOG4105C31	Tryptophanyl-tRNA synthetase
WM2015_1513	ENOG4106PVI	ATP-dependent carboxylate-amine ligase (By similarity)
WM2015_1515	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
WM2015_1520	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WM2015_1521	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
WM2015_1526	ENOG4105EHV	domain protein
WM2015_1527	ENOG4105M3Z	response regulator
WM2015_1530	ENOG4105C7S	Dehydrogenase
WM2015_1531	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
WM2015_1532	ENOG4105EZE	Cupin 4 family protein
WM2015_1533	ENOG4107QTF	adenylosuccinate lyase
WM2015_1538	ENOG4108RU0	short-chain dehydrogenase reductase
WM2015_1539	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
WM2015_154	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
WM2015_1540	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
WM2015_1542	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
WM2015_1544	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
WM2015_1545	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
WM2015_1546	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
WM2015_1548	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
WM2015_1550	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
WM2015_1553	ENOG4105CUT	histidyl-tRNA synthetase
WM2015_1554	ENOG4105N21	Membrane
WM2015_1555	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
WM2015_1556	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
WM2015_1558	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
WM2015_156	ENOG4105E55	glycerol-3-phosphate acyltransferase
WM2015_1560	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
WM2015_1562	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
WM2015_1563	ENOG4105CHU	acetyl-coa acetyltransferase
WM2015_1564	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
WM2015_1565	ENOG4108UHJ	MAF-like protein
WM2015_1566	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
WM2015_1567	ENOG4105VGS	50s ribosomal protein l32
WM2015_1568	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
WM2015_1569	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
WM2015_157	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
WM2015_1570	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
WM2015_1571	ENOG4105CHR	reductase
WM2015_1572	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
WM2015_1573	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
WM2015_1575	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
WM2015_1576	ENOG4105HHA	aminodeoxychorismate lyase
WM2015_1577	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
WM2015_1578	ENOG4107QRG	dna polymerase iii
WM2015_158	ENOG4108YIQ	Alpha beta hydrolase
WM2015_1580	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
WM2015_1581	ENOG4105CEY	Amp-dependent synthetase and ligase
WM2015_1584	ENOG4107QRT	dEAD DEAH box helicase
WM2015_1585	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
WM2015_1586	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
WM2015_1589	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
WM2015_159	ENOG4105C4R	Atp-dependent dna helicase
WM2015_1591	ENOG4105C26	Dehydrogenase
WM2015_1596	ENOG4105CFC	Transporter
WM2015_1597	ENOG4105PXI	polysaccharide deacetylase
WM2015_1598	ENOG4105CN1	protease
WM2015_1599	ENOG41063SB	peptidase
WM2015_160	ENOG4105C12	Phosphoribosylglycinamide synthetase
WM2015_1600	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
WM2015_1601	ENOG4107YZP	Rhodanese domain protein
WM2015_1602	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
WM2015_1603	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
WM2015_1604	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
WM2015_1605	ENOG4107QYD	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
WM2015_161	ENOG4105DC1	bifunctional purine biosynthesis protein purh
WM2015_1617	ENOG4108REF	Sporulation integral membrane protein ytvi
WM2015_1619	ENOG4107S6Z	Na H antiporter
WM2015_1620	ENOG4105C0B	DNA polymerase III (alpha subunit)
WM2015_1621	ENOG4105VEJ	Heat shock protein
WM2015_1623	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
WM2015_1627	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
WM2015_1628	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
WM2015_1629	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
WM2015_1630	ENOG4105K5M	30s ribosomal protein S16
WM2015_1633	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
WM2015_1634	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
WM2015_1635	ENOG4106H78	methyltransferase
WM2015_1636	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
WM2015_1637	ENOG4105CEN	a g-specific adenine glycosylase
WM2015_1639	ENOG4105BZU	Histidine kinase
WM2015_1641	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
WM2015_1643	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
WM2015_1645	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
WM2015_1646	ENOG4107YZX	Universal stress protein
WM2015_1647	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
WM2015_1648	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
WM2015_165	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
WM2015_1650	ENOG4107YRI	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
WM2015_1653	ENOG4105K9H	YciI-like protein
WM2015_1654	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
WM2015_1655	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
WM2015_1656	ENOG4105FE9	pseudouridine synthase
WM2015_1658	ENOG4105C2N	RNA methyltransferase TrmH family group 3
WM2015_1659	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
WM2015_166	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
WM2015_1660	ENOG4105E9H	Lytic Murein transglycosylase
WM2015_1663	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
WM2015_1664	ENOG4105WJX	transcriptional regulator MERR family
WM2015_1665	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
WM2015_1666	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
WM2015_1669	ENOG41082NX	50s ribosomal protein l35
WM2015_1670	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
WM2015_1671	ENOG4105C22	threonyL-tRNA synthetase
WM2015_1677	ENOG4108IJF	Heavy metal efflux pump, CzcA
WM2015_1682	ENOG4105C1J	atp-dependent rna helicase
WM2015_1683	ENOG4105FQ6	thiopurine methyltransferase
WM2015_1687	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
WM2015_1689	ENOG4105KA0	thioesterase Superfamily protein
WM2015_169	ENOG4107RDJ	Sulfotransferase
WM2015_1690	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
WM2015_1691	ENOG4105CQB	FAD linked oxidase domain protein
WM2015_1692	ENOG4108JQ1	Dehydrogenase
WM2015_1694	ENOG4105C8Y	Acetylornithine aminotransferase
WM2015_1695	ENOG4105KKX	ATPase associated with various cellular activities aaa_5
WM2015_1696	ENOG4107QHF	type ii secretion system protein e
WM2015_1697	ENOG4105K59	histidine triad (HIT) protein
WM2015_1698	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
WM2015_17	ENOG4105C8J	)-transporter
WM2015_170	ENOG4105CGK	Exodeoxyribonuclease III
WM2015_1702	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
WM2015_1703	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
WM2015_1705	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
WM2015_1706	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
WM2015_1707	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
WM2015_1709	ENOG4105D0M	Protease HtpX homolog
WM2015_1710	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
WM2015_1722	ENOG41083PU	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
WM2015_1723	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
WM2015_1724	ENOG4107YDW	inorganic pyrophosphatase EC 3.6.1.1
WM2015_1727	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WM2015_1730	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
WM2015_1737	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
WM2015_1738	ENOG4105JNK	Glycosyl transferase (Group 1
WM2015_1742	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
WM2015_1743	ENOG4105EEI	dihydropteroate synthase
WM2015_1745	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
WM2015_1746	ENOG4105HBR	Rna-binding protein
WM2015_1748	ENOG4105CSU	acyl-Coa dehydrogenase
WM2015_1750	ENOG4108X7C	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
WM2015_1751	ENOG4105D3R	alkyl hydroperoxide reductase
WM2015_1752	ENOG4105C5Q	Transcriptional regulator
WM2015_1756	ENOG4105CJ1	ABC, transporter
WM2015_1763	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
WM2015_1764	ENOG4105DF3	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity)
WM2015_1765	ENOG4105BZN	citrate synthase
WM2015_1766	ENOG4105CR4	methylisocitrate lyase
WM2015_1767	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
WM2015_1768	ENOG4105MIR	Phenylalanine 4-monooxygenase
WM2015_1769	ENOG41090A4	Pterin carbinolamine dehydratase
WM2015_177	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
WM2015_1770	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
WM2015_1772	ENOG4105F8C	transglutaminase domain-containing protein
WM2015_1773	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
WM2015_1774	ENOG4105CZ7	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
WM2015_1775	ENOG4105ED9	Protein of unknown function (DUF455)
WM2015_178	ENOG4108K5P	(LipO)protein
WM2015_1784	ENOG4108VYJ	response regulator receiver protein
WM2015_1785	ENOG4105CFH	Aspartokinase
WM2015_1786	ENOG4105C28	cystathionine
WM2015_1787	ENOG4105DWV	Homoserine O-trans-acetylase
WM2015_1789	ENOG4107R11	Transcriptional regulator
WM2015_179	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
WM2015_1790	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
WM2015_1792	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WM2015_1794	ENOG4105PDP	Short chain dehydrogenase
WM2015_1802	ENOG4105HJ8	Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity)
WM2015_1803	ENOG4107RUY	(E1 component), alpha subunit
WM2015_1804	ENOG4105CPP	Dehydrogenase, E1 component
WM2015_1805	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
WM2015_1806	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
WM2015_1807	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
WM2015_1810	ENOG4105E33	succinate dehydrogenase
WM2015_1813	ENOG410612Q	succinate dehydrogenase (cytochrome b-556 subunit)
WM2015_1815	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
WM2015_1819	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
WM2015_182	ENOG4108RAC	Rubrerythrin
WM2015_1821	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
WM2015_1823	ENOG4105BZ1	(ABC) transporter
WM2015_1824	ENOG4109015	Biopolymer transport protein exbD tolR
WM2015_1826	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
WM2015_1827	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
WM2015_1828	ENOG4105D60	lipoprotein releasing system transmembrane protein
WM2015_1829	ENOG4105EI2	Pseudouridine synthase
WM2015_1830	ENOG4105C03	ribonuclease
WM2015_1832	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
WM2015_1834	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WM2015_1835	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
WM2015_1836	ENOG41090R7	Ferric uptake
WM2015_1837	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
WM2015_1838	ENOG4105VDB	UPF0125 protein
WM2015_1839	ENOG4108Z1B	Cyclase dehydrase
WM2015_184	ENOG4105DBV	ornithine carbamoyltransferase
WM2015_1840	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
WM2015_1842	ENOG4105CMM	transposase
WM2015_1845	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
WM2015_1846	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
WM2015_1849	ENOG4105K8N	protein family UPF0079, ATPase
WM2015_185	ENOG4105CDH	Citrulline--aspartate ligase
WM2015_1850	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
WM2015_1851	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
WM2015_1852	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
WM2015_1854	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
WM2015_1855	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
WM2015_1856	ENOG4105C8U	phosphate abc transporter
WM2015_1857	ENOG4105C8U	phosphate abc transporter
WM2015_1863	ENOG4109015	Biopolymer transport protein exbD tolR
WM2015_1867	ENOG4105BZU	Histidine kinase
WM2015_1868	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
WM2015_187	ENOG4105CAS	nag kinase
WM2015_1870	ENOG4105MYN	Zinc uptake regulation protein
WM2015_1871	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
WM2015_1872	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
WM2015_1873	ENOG4108JDX	DNA polymerase iii, epsilon subunit
WM2015_1874	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
WM2015_1876	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
WM2015_1884	ENOG4105KHS	type IV fimbrial pilin protein
WM2015_1886	ENOG4107QHF	type ii secretion system protein e
WM2015_189	ENOG4105CH7	arginosuccinase
WM2015_1891	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
WM2015_1892	ENOG4105K63	Thioredoxin
WM2015_1893	ENOG4105C1J	atp-dependent rna helicase
WM2015_1894	ENOG4105C0H	protease
WM2015_1896	ENOG4107QHF	type ii secretion system protein e
WM2015_1897	ENOG4105D7Q	type ii secretion system
WM2015_1899	ENOG4105CAK	Cell division ATP-binding protein ftsE
WM2015_19	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
WM2015_1900	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
WM2015_1901	ENOG4108ZEY	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
WM2015_1905	ENOG4105DHQ	Histidine kinase
WM2015_1906	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
WM2015_1908	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
WM2015_191	ENOG4105CK2	sodium dicarboxylate symporter
WM2015_1914	ENOG4107QPN	acyl-Coa dehydrogenase
WM2015_1916	ENOG4105CHU	acetyl-coa acetyltransferase
WM2015_192	ENOG4105CX6	glutaminyL-tRNA synthetase
WM2015_1920	ENOG4105D9P	serine threonine protein kinase
WM2015_1923	ENOG4105C1G	acyl-Coa dehydrogenase
WM2015_1925	ENOG4105C29	acyl-CoA thioesterase
WM2015_1928	ENOG410601J	HemY protein
WM2015_1930	ENOG41076E6	Uroporphyrinogen-III Synthase
WM2015_1931	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
WM2015_1932	ENOG4108NEV	two component transcriptional regulator, LytTR family
WM2015_1935	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
WM2015_1936	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
WM2015_1938	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
WM2015_1939	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
WM2015_1940	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
WM2015_1941	ENOG4105DHJ	ABC, transporter
WM2015_1942	ENOG4105CY3	ABC transporter, permease
WM2015_1943	ENOG4107PE3	Mammalian cell entry related domain protein
WM2015_1947	ENOG4105BZU	Histidine kinase
WM2015_1948	ENOG41082YX	Transcriptional regulator, arsr family
WM2015_1949	ENOG4105C3R	Methionine synthase
WM2015_1950	ENOG4105C3R	Methionine synthase
WM2015_1952	ENOG4108V1T	peptidylprolyl cis-trans isomerase
WM2015_1955	ENOG4105CZV	ABC transporter
WM2015_1959	ENOG4105CD3	dihydroorotase
WM2015_196	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
WM2015_1960	ENOG4105CE4	GlcNAc 6-P deacetylase
WM2015_1961	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
WM2015_1962	ENOG4105DZQ	phospholipase D Transphosphatidylase
WM2015_1965	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
WM2015_1968	ENOG4105C4K	Nad synthetase
WM2015_1969	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
WM2015_1971	ENOG4107TUY	Histidine kinase
WM2015_1972	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
WM2015_1977	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
WM2015_1978	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
WM2015_1979	ENOG41080I0	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
WM2015_1981	ENOG4105C26	Dehydrogenase
WM2015_1984	ENOG4107TE5	Lipid kinase
WM2015_1985	ENOG4107ENK	receptor
WM2015_1986	ENOG4107F3C	Hemin uptake protein
WM2015_1990	ENOG4105KSC	Transcriptional regulator, TraR DksA family
WM2015_1992	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
WM2015_1994	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WM2015_1995	ENOG4105K46	50S ribosomal protein l27
WM2015_1996	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
WM2015_1998	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
WM2015_2	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
WM2015_200	ENOG410804D	Sensor Signal Transduction Histidine Kinase
WM2015_2007	ENOG4108V1T	peptidylprolyl cis-trans isomerase
WM2015_2008	ENOG41087YS	Phage shock protein A
WM2015_201	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
WM2015_2012	ENOG4105E39	Enoyl-CoA hydratase
WM2015_2017	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
WM2015_2018	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
WM2015_2021	ENOG4108UUM	single-stranded DNA-binding protein
WM2015_2022	ENOG4105EAH	synthase
WM2015_2023	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
WM2015_2027	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
WM2015_2028	ENOG4105VW4	glutaredoxin 3
WM2015_203	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
WM2015_2031	ENOG4105ERG	peptidase m48, ste24p
WM2015_2032	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
WM2015_2033	ENOG4105C9X	ppx gppa phosphatase
WM2015_2034	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
WM2015_2037	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
WM2015_2039	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
WM2015_204	ENOG4105D6S	protein involved in catabolism of external DNA
WM2015_2040	ENOG4105E96	Colicin v production protein
WM2015_2042	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
WM2015_2043	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
WM2015_2044	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
WM2015_2045	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
WM2015_2046	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
WM2015_2047	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
WM2015_2049	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
WM2015_205	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
WM2015_2050	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
WM2015_2051	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
WM2015_2052	ENOG4108UJV	acyl-CoA thioesterase i
WM2015_2053	ENOG4108I0Y	(ABC) transporter
WM2015_2058	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WM2015_206	ENOG4105BZS	acriflavin resistance protein
WM2015_2063	ENOG41082CG	Protein CrcB homolog
WM2015_2064	ENOG4105DGW	oligopeptidase A
WM2015_2065	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WM2015_2066	ENOG4106KVJ	cytochrome C assembly protein
WM2015_2067	ENOG4108JU6	CBS domain protein
WM2015_2069	ENOG4105BZU	Histidine kinase
WM2015_207	ENOG4105KAV	tspo and mbr like protein
WM2015_2071	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
WM2015_2073	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
WM2015_2075	ENOG4105C3F	Signal peptidase i
WM2015_2076	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
WM2015_2077	ENOG4105C0H	protease
WM2015_208	ENOG4105I82	acetyl xylan esterase
WM2015_2081	ENOG4105EMN	RNA polymerase sigma factor
WM2015_2082	ENOG4105C26	Dehydrogenase
WM2015_2083	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
WM2015_2084	ENOG4105D4A	Cell wall formation (By similarity)
WM2015_2086	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
WM2015_2090	ENOG4105CFH	Aspartokinase
WM2015_2092	ENOG4105MPN	Membrane
WM2015_2093	ENOG4105C59	p-type ATPase
WM2015_210	ENOG4106FGB	Beta-lactamase
WM2015_2111	ENOG4105C84	Histidine ammonia-lyase
WM2015_2112	ENOG4105CI2	imidazolone-5-propionate hydrolase
WM2015_2116	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
WM2015_2117	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
WM2015_2118	ENOG4105VIE	preprotein translocase, subunit YajC
WM2015_212	ENOG4105CYM	Glutathione S-transferase
WM2015_2122	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
WM2015_2124	ENOG4105D9P	serine threonine protein kinase
WM2015_2126	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
WM2015_2127	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
WM2015_2130	ENOG4105CKY	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
WM2015_2131	ENOG4107RQD	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
WM2015_2135	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
WM2015_2136	ENOG4105DC8	reductase
WM2015_2137	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
WM2015_2138	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
WM2015_2139	ENOG41060IM	Heme exporter protein
WM2015_214	ENOG4107YPT	transcriptional regulator
WM2015_2141	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
WM2015_2142	ENOG4105DA4	cytochrome c-type biogenesis protein
WM2015_2143	ENOG4107QX9	Thiol disulfide interChange protein
WM2015_2144	ENOG4105KWW	Biogenesis protein
WM2015_2145	ENOG4108M1T	Cytochrome c-type biogenesis protein
WM2015_2146	ENOG4107IX6	phosphate transport regulator
WM2015_2147	ENOG4105CJ3	phosphate transporter
WM2015_2151	ENOG4105CJR	Integral membrane protein (MviN
WM2015_2152	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
WM2015_2153	ENOG4107YZX	Universal stress protein
WM2015_2154	ENOG4105E4C	Lytic transglycosylase catalytic
WM2015_2157	ENOG4105CJB	Exodeoxyribonuclease I
WM2015_2159	ENOG4105KQC	Competence protein
WM2015_2160	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
WM2015_2161	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
WM2015_2162	ENOG4107QMP	dna polymerase iii subunits gamma and tau
WM2015_2163	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
WM2015_2164	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
WM2015_2165	ENOG4108V0P	LemA family
WM2015_2167	ENOG4105CHM	Aminotransferase
WM2015_2169	ENOG4106RHG	Yeca family
WM2015_2170	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
WM2015_2179	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
WM2015_219	ENOG4105BZU	Histidine kinase
WM2015_2190	ENOG4105FQP	Beta-lactamase
WM2015_2194	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
WM2015_2196	ENOG4105JAB	phenazine biosynthesis protein, phzf family
WM2015_2197	ENOG4108UPT	UPF0178 protein
WM2015_2198	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
WM2015_2199	ENOG4105E1V	na solute symporter
WM2015_22	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
WM2015_2204	ENOG4105CHU	acetyl-coa acetyltransferase
WM2015_2205	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
WM2015_2212	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
WM2015_2220	ENOG4105C10	Electron transfer flavoprotein
WM2015_2221	ENOG4105BZJ	Electron transfer flavoprotein
WM2015_2222	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
WM2015_2224	ENOG4105DJ4	phosphatidylserine decarboxylase
WM2015_2228	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
WM2015_223	ENOG4105E39	Enoyl-CoA hydratase
WM2015_2230	ENOG41082RQ	UPF0102 protein
WM2015_2232	ENOG4108ZAI	phosphatidylglycerophosphatase a
WM2015_2233	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
WM2015_2234	ENOG4107YIM	Involved in the transcription termination process (By similarity)
WM2015_2235	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
WM2015_2236	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
WM2015_2238	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
WM2015_2239	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
WM2015_2240	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
WM2015_2243	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
WM2015_2246	ENOG4105WH1	Two component transcriptional regulator luxr family
WM2015_2247	ENOG4105EEF	Alkane 1-monooxygenase
WM2015_2251	ENOG4107QKV	phosphomannomutase
WM2015_2254	ENOG4107QQG	Dehydrogenase
WM2015_2255	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
WM2015_2258	ENOG4108UT2	hemolysin iii
WM2015_226	ENOG4105DFF	Rod shape-determining protein mreb
WM2015_2260	ENOG4105BZ1	(ABC) transporter
WM2015_2261	ENOG4105FR1	rard protein
WM2015_2263	ENOG4108ZT0	50S ribosomal protein l17
WM2015_2264	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
WM2015_2266	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
WM2015_2267	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WM2015_2268	ENOG41067V7	50S ribosomal protein L36
WM2015_2269	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
WM2015_227	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
WM2015_2270	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
WM2015_2271	ENOG4105VPB	50S ribosomal protein L30
WM2015_2272	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
WM2015_2273	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
WM2015_2274	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
WM2015_2275	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
WM2015_2276	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
WM2015_2277	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WM2015_2278	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
WM2015_2279	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
WM2015_2280	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
WM2015_2281	ENOG41083MP	50s ribosomal protein l29
WM2015_2282	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
WM2015_2283	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
WM2015_2284	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
WM2015_2285	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
WM2015_2286	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WM2015_2287	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
WM2015_2288	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
WM2015_2289	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
WM2015_229	ENOG4105CJN	penicillin-binding protein
WM2015_2290	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
WM2015_2291	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
WM2015_2292	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
WM2015_2293	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
WM2015_2294	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
WM2015_23	ENOG41080ZE	Adenylate cyclase
WM2015_230	ENOG4105CNI	cell division protein FtsW
WM2015_2302	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
WM2015_2303	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
WM2015_2304	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
WM2015_2305	ENOG4108VZM	50s ribosomal protein L10
WM2015_2306	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
WM2015_2307	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
WM2015_2308	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
WM2015_2309	ENOG4105PM1	preprotein translocase subunit SecE
WM2015_231	ENOG4105CVE	Lytic murein transglycosylase
WM2015_2310	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
WM2015_2311	ENOG4105C3G	gtp-binding protein
WM2015_2312	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
WM2015_2313	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
WM2015_2314	ENOG4108MN8	Membrane
WM2015_2317	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
WM2015_2318	ENOG4105DTN	riboflavin biosynthesis protein ribF
WM2015_2328	ENOG4105DR9	pseudouridine synthase
WM2015_2329	ENOG41062A4	Transcriptional regulator
WM2015_233	ENOG4105DZ1	carboxypeptidase
WM2015_2330	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
WM2015_2331	ENOG4105F1J	Homogentisate 1,2-dioxygenase
WM2015_2336	ENOG4105DHQ	Histidine kinase
WM2015_2337	ENOG4105ETX	regulatoR
WM2015_2338	ENOG4105TMR	Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity)
WM2015_234	ENOG4108Z43	UPF0250 protein
WM2015_2344	ENOG4108RXX	maleylacetoacetate isomerase
WM2015_2346	ENOG4105UYK	outer membrane protein a
WM2015_2349	ENOG4105CFC	Transporter
WM2015_235	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
WM2015_2353	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
WM2015_2356	ENOG4105M6F	mutator MutT protein
WM2015_2357	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
WM2015_2359	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
WM2015_236	ENOG4105CN1	protease
WM2015_2360	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
WM2015_2361	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
WM2015_2363	ENOG4105CPF	Cell wall formation (By similarity)
WM2015_2364	ENOG4105DFU	Cell wall formation (By similarity)
WM2015_2365	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
WM2015_2367	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
WM2015_2368	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
WM2015_2369	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
WM2015_237	ENOG4105C25	Primosomal protein n'
WM2015_2370	ENOG4105CJN	penicillin-binding protein
WM2015_2371	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
WM2015_2372	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
WM2015_2373	ENOG4108V6E	Cell division protein mraZ
WM2015_2375	ENOG4105EWT	decarboxylase family
WM2015_2376	ENOG4108KPZ	tonB-dependent Receptor
WM2015_2379	ENOG4105D1H	recombination factor protein RarA
WM2015_2387	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
WM2015_2388	ENOG4105CPK	Glycosyl transferase (Group 1
WM2015_2389	ENOG410901P	UPF0249 protein
WM2015_2390	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
WM2015_2396	ENOG4105EGZ	biosynthesis protein
WM2015_2397	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
WM2015_2399	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
WM2015_240	ENOG4105NRA	50s ribosomal protein l31 type b
WM2015_2402	ENOG4107YJ4	chain length determinant protein
WM2015_2405	ENOG4108UK5	Transposase
WM2015_2406	ENOG4105BZU	Histidine kinase
WM2015_2408	ENOG4105CY2	Citrate transporter
WM2015_2411	ENOG4105C28	cystathionine
WM2015_2413	ENOG4105E2T	synthase III
WM2015_2414	ENOG4108J2P	Alpha beta hydrolase fold
WM2015_2415	ENOG410680H	amp-dependent synthetase and ligase
WM2015_2416	ENOG4105ESV	Glycosyl transferase, family 4
WM2015_2419	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
WM2015_2421	ENOG4105CJZ	response regulator
WM2015_2423	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
WM2015_2424	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
WM2015_2425	ENOG4105ECY	inositol monophosphatase
WM2015_2426	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
WM2015_2428	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
WM2015_2429	ENOG41080Z8	PHOSPHOCARRIER protein
WM2015_2431	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
WM2015_2432	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
WM2015_2433	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
WM2015_2434	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
WM2015_2435	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
WM2015_2438	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
WM2015_2439	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
WM2015_2440	ENOG4105CHV	Transcription elongation factor NusA
WM2015_2448	ENOG4105IIU	Aminopeptidase
WM2015_2450	ENOG4105D9P	serine threonine protein kinase
WM2015_2453	ENOG4105JRK	feS assembly protein SufD
WM2015_2454	ENOG4105C3K	feS assembly ATPase SufC
WM2015_2459	ENOG4105EHM	Aminoglycoside phosphotransferase
WM2015_2460	ENOG4108S0S	Nucleotidyl transferase
WM2015_2461	ENOG4105G6Z	alkaline phosphatase
WM2015_2463	ENOG4105CAQ	asparagine synthetase
WM2015_2464	ENOG4108KZ1	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity)
WM2015_2465	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
WM2015_2468	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
WM2015_2470	ENOG4105D0M	Protease HtpX homolog
WM2015_2475	ENOG4105CD8	aminopeptidase N
WM2015_248	ENOG4106855	Competence protein
WM2015_2480	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
WM2015_2483	ENOG4105E4G	Type IV pilus
WM2015_2488	ENOG4108JQC	penicillin-binding protein 1A
WM2015_2493	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
WM2015_2497	ENOG4105D07	Signal peptide peptidase, SppA
WM2015_2498	ENOG4107QI1	Mate efflux family protein
WM2015_25	ENOG4105C28	cystathionine
WM2015_2500	ENOG4105D9P	serine threonine protein kinase
WM2015_2504	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
WM2015_2506	ENOG4108SNX	Mammalian cell entry related domain protein
WM2015_2507	ENOG4105DHJ	ABC, transporter
WM2015_251	ENOG4105CSA	Coproporphyrinogen iii oxidase
WM2015_2510	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
WM2015_2513	ENOG4109066	lysm domain bon superfamily protein
WM2015_2514	ENOG4105BZU	Histidine kinase
WM2015_2516	ENOG4107QN1	sodium solute
WM2015_2520	ENOG4108IRC	dna polymerase iii
WM2015_2521	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
WM2015_2529	ENOG4105BZU	Histidine kinase
WM2015_253	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
WM2015_2533	ENOG4105DHZ	alpha beta
WM2015_2534	ENOG4105D6Z	AFG1 family ATPase
WM2015_2537	ENOG4107QPN	acyl-Coa dehydrogenase
WM2015_2538	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
WM2015_2539	ENOG4105CJ2	(LipO)protein
WM2015_254	ENOG4105DSJ	YicC domain protein
WM2015_2540	ENOG4105BZU	Histidine kinase
WM2015_2546	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
WM2015_2547	ENOG4105EHG	Permease protein
WM2015_2548	ENOG4105E0A	ABC, transporter
WM2015_255	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
WM2015_2553	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
WM2015_2555	ENOG4105BZU	Histidine kinase
WM2015_2556	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
WM2015_2558	ENOG4107SC1	transglycosylase
WM2015_2559	ENOG4105HF0	Membrane
WM2015_256	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
WM2015_2562	ENOG4106RE7	Cytochrome
WM2015_2563	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
WM2015_2565	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
WM2015_257	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
WM2015_2573	ENOG4105F8V	Hydrolase, tatD family
WM2015_2575	ENOG4105WD1	Membrane
WM2015_2580	ENOG4109015	Biopolymer transport protein exbD tolR
WM2015_2581	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
WM2015_2582	ENOG4105C2M	dna polymerase I
WM2015_2584	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
WM2015_2585	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
WM2015_2586	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
WM2015_2587	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
WM2015_2589	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
WM2015_259	ENOG4105CB5	ATP-dependent DNA helicase recG
WM2015_2591	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
WM2015_2597	ENOG4105EYF	MMPL domain protein
WM2015_2599	ENOG4105D25	secreted protein
WM2015_26	ENOG4105BZU	Histidine kinase
WM2015_2603	ENOG4105K3M	)-transporter
WM2015_2606	ENOG4107SE4	UDP-N-acetylglucosamine 2-epimerase
WM2015_2613	ENOG4107QN2	dihydrolipoyl dehydrogenase
WM2015_2614	ENOG4105D9P	serine threonine protein kinase
WM2015_2617	ENOG4107QSN	dihydrolipoamide acetyltransferase
WM2015_2618	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
WM2015_2619	ENOG4106IPI	cyclase, family
WM2015_2621	ENOG4105C6K	Malic enzyme
WM2015_2622	ENOG4107R1Y	fructose-bisphosphate aldolase
WM2015_2623	ENOG4105CA9	Pyruvate kinase
WM2015_2624	ENOG4105CYM	Glutathione S-transferase
WM2015_2626	ENOG4108K8S	endonuclease I
WM2015_2630	ENOG4105VZ8	Transcriptional regulator
WM2015_264	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
WM2015_2643	ENOG4105CKK	Glycosyl transferase, family 2
WM2015_2649	ENOG4105D0M	Protease HtpX homolog
WM2015_265	ENOG4108KF1	Membrane
WM2015_2652	ENOG4105BZU	Histidine kinase
WM2015_266	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
WM2015_2662	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
WM2015_2668	ENOG4108ESX	Receptor
WM2015_267	ENOG4105DFU	Cell wall formation (By similarity)
WM2015_2672	ENOG4105EZE	Cupin 4 family protein
WM2015_2677	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
WM2015_2679	ENOG4107QHI	-hydrogenase
WM2015_269	ENOG41084XP	SirA-like domain-containing protein
WM2015_2690	ENOG4105DDY	UPF0142 protein ycaO
WM2015_2692	ENOG4105C0H	protease
WM2015_2693	ENOG4105K63	Thioredoxin
WM2015_2699	ENOG4105CMM	transposase
WM2015_270	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
WM2015_2702	ENOG4105BZA	Phosphoglycerate kinase
WM2015_2703	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
WM2015_2704	ENOG4105CV1	Transketolase (EC 2.2.1.1)
WM2015_2708	ENOG4105DHQ	Histidine kinase
WM2015_271	ENOG4105CTQ	phosphohexokinase
WM2015_2710	ENOG4105CZX	twitching motility protein
WM2015_2711	ENOG4105CZX	twitching motility protein
WM2015_2712	ENOG4105DFA	alanine racemase domain protein
WM2015_2713	ENOG4105II7	pyrroline-5-carboxylate reductase
WM2015_2714	ENOG4108VIA	integral membrane protein
WM2015_2719	ENOG4108YZA	Nitrogen regulatory protein pii
WM2015_272	ENOG4105D9N	nucleoside
WM2015_2720	ENOG4105W0Z	cytoplasmic protein
WM2015_2721	ENOG4105BZU	Histidine kinase
WM2015_2722	ENOG4105C0P	Mg chelatase subunit ChlI
WM2015_2723	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WM2015_2725	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
WM2015_273	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
WM2015_2731	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
WM2015_2735	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
WM2015_2736	ENOG4105BZU	Histidine kinase
WM2015_2737	ENOG4108YXG	UPF0502 protein
WM2015_2742	ENOG4108NJZ	Sensory box GGDEF EAL domain protein
WM2015_2745	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
WM2015_2747	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
WM2015_2750	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
WM2015_2754	ENOG4105C59	p-type ATPase
WM2015_276	ENOG4105GFR	rna polymerase sigma factor
WM2015_2762	ENOG4105D4P	Coproporphyrinogen iii oxidase
WM2015_2763	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
WM2015_2769	ENOG4105C5F	glutamine synthetase
WM2015_2771	ENOG4105CUX	Signal transduction histidine kinase
WM2015_2772	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
WM2015_2773	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
WM2015_2775	ENOG4105WKW	Pfam:DUF1458
WM2015_2776	ENOG4105D0M	Protease HtpX homolog
WM2015_2777	ENOG4108V0P	LemA family
WM2015_2778	ENOG4105BZU	Histidine kinase
WM2015_2782	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
WM2015_2785	ENOG4105D9P	serine threonine protein kinase
WM2015_279	ENOG4105E0X	reductase
WM2015_2793	ENOG4108JUA	Transcriptional regulator
WM2015_2794	ENOG4105D9P	serine threonine protein kinase
WM2015_280	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WM2015_2800	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
WM2015_2807	ENOG41082BM	Transcriptional regulator, arsr family
WM2015_2808	ENOG4105DR5	peptidase
WM2015_2809	ENOG4105EJQ	L-serine dehydratase
WM2015_2811	ENOG4105CJP	fad dependent oxidoreductase
WM2015_2815	ENOG4105DP4	dak2 domain fusion protein ylov
WM2015_2816	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
WM2015_2817	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
WM2015_2818	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
WM2015_282	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
WM2015_2820	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
WM2015_2821	ENOG4105MJ2	Competence protein
WM2015_2822	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
WM2015_2823	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
WM2015_2827	ENOG4105BZU	Histidine kinase
WM2015_2828	ENOG4105BZU	Histidine kinase
WM2015_283	ENOG4105VCC	30S ribosomal protein S21
WM2015_2830	ENOG4108VWS	Yaeq family
WM2015_2836	ENOG4106TD9	Diguanylate cyclase
WM2015_2837	ENOG4105EMU	Dehydrogenase
WM2015_2839	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
WM2015_2842	ENOG4105RYD	Toxic component of a toxin-antitoxin (TA) module. A
WM2015_285	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
WM2015_286	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
WM2015_2863	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
WM2015_2864	ENOG41083X2	DNA polymerase III, epsilon subunit
WM2015_2867	ENOG4105KRP	Plasmid stabilization system
WM2015_2868	ENOG4105YAJ	CopG Arc MetJ
WM2015_2869	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
WM2015_2876	ENOG4105DZP	Membrane-associated zinc metalloprotease
WM2015_2881	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
WM2015_2885	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
WM2015_2887	ENOG4105EUB	pirin domain protein
WM2015_2888	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
WM2015_2889	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
WM2015_2891	ENOG4105EG6	Saccharopine dehydrogenase
WM2015_2892	ENOG4105EKE	dihydroorotase
WM2015_2895	ENOG4107TE5	Lipid kinase
WM2015_2898	ENOG4108VPT	UPF0234 protein
WM2015_2899	ENOG4106HNH	Acyl-transferase
WM2015_2900	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
WM2015_2901	ENOG4105CHR	reductase
WM2015_2903	ENOG4105CSU	acyl-Coa dehydrogenase
WM2015_2909	ENOG4108115	UPF0145 protein
WM2015_291	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
WM2015_2913	ENOG4105CQB	FAD linked oxidase domain protein
WM2015_292	ENOG4105D49	3-dehydroquinate synthase
WM2015_2920	ENOG4105EUB	pirin domain protein
WM2015_2921	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
WM2015_2925	ENOG4105CQ7	ATP-dependent helicase
WM2015_2926	ENOG4105CQ7	ATP-dependent helicase
WM2015_293	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
WM2015_2934	ENOG4105CKW	Inner membrane protein yedI
WM2015_2937	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
WM2015_2938	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
WM2015_2943	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
WM2015_2947	ENOG4107QJN	gtp cyclohydrolase ii
WM2015_2949	ENOG4105UGU	tonB-dependent Receptor
WM2015_2957	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
WM2015_2958	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
WM2015_296	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
WM2015_2963	ENOG4105BZG	amino acid carrier protein
WM2015_2964	ENOG4105D8V	Glucose sorbosone dehydrogenase
WM2015_2968	ENOG4105C75	arginyL-tRNA synthetase
WM2015_2969	ENOG4108Z0R	Transferase
WM2015_297	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
WM2015_2970	ENOG4105CV8	reductase
WM2015_2972	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
WM2015_2973	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
WM2015_2976	ENOG4105E3A	(ABC) transporter
WM2015_2977	ENOG4105DA5	(ABC) transporter
WM2015_2979	ENOG4108IUW	ABC transporter
WM2015_2980	ENOG4108SDH	ABC, transporter
WM2015_2982	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
WM2015_2989	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
WM2015_299	ENOG4105C9U	ATP-dependent DNA helicase RecQ
WM2015_2990	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
WM2015_2991	ENOG4105CIH	Imidazole acetol-phosphate transaminase
WM2015_2992	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
WM2015_2994	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
WM2015_2995	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
WM2015_2996	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
WM2015_2997	ENOG4108KMM	Diguanylate cyclase
WM2015_3	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
WM2015_30	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
WM2015_300	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
WM2015_3000	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
WM2015_3003	ENOG4105D5U	fad dependent oxidoreductase
WM2015_3009	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
WM2015_3014	ENOG4105C2D	reductase
WM2015_302	ENOG41086H8	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
WM2015_303	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
WM2015_3030	ENOG4108UVJ	appr-1-p processing domain protein
WM2015_3034	ENOG4105BZU	Histidine kinase
WM2015_3045	ENOG4105EQR	Transposase IS116 IS110 IS902
WM2015_3046	ENOG4105EQR	Transposase IS116 IS110 IS902
WM2015_3048	ENOG4105EQR	Transposase IS116 IS110 IS902
WM2015_3050	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
WM2015_3052	ENOG4105VCQ	rubredoxin
WM2015_3053	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
WM2015_3055	ENOG4105C4R	Atp-dependent dna helicase
WM2015_3059	ENOG4105ETT	transcriptional Regulator, LysR family
WM2015_306	ENOG4108URH	decarboxylase
WM2015_3062	ENOG4105CHF	Glutathione S-transferase
WM2015_3064	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
WM2015_3065	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
WM2015_3066	ENOG41067YR	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
WM2015_312	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
WM2015_313	ENOG4108RPN	Protein smg homolog
WM2015_314	ENOG4105C79	DNA protecting protein DprA
WM2015_316	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
WM2015_318	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
WM2015_32	ENOG4108YZA	Nitrogen regulatory protein pii
WM2015_320	ENOG4105ES5	Histidine kinase
WM2015_321	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
WM2015_322	ENOG4105C1A	potassium transporter peripheral membrane
WM2015_323	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
WM2015_324	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
WM2015_327	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
WM2015_330	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
WM2015_331	ENOG4105D60	lipoprotein releasing system transmembrane protein
WM2015_335	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
WM2015_337	ENOG4105C7Z	Conserved Protein
WM2015_338	ENOG4106TD9	Diguanylate cyclase
WM2015_341	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
WM2015_343	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
WM2015_346	ENOG4105D52	delta-aminolevulinic acid dehydratase
WM2015_347	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
WM2015_350	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
WM2015_351	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
WM2015_353	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
WM2015_354	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
WM2015_355	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
WM2015_357	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
WM2015_358	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WM2015_359	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
WM2015_36	ENOG4105D7A	ATP-binding protein
WM2015_360	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
WM2015_361	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
WM2015_363	ENOG4105CBS	Chea signal transduction histidine kinase
WM2015_364	ENOG4105C8Q	Methyl-accepting chemotaxis
WM2015_366	ENOG4108UNF	response regulator
WM2015_367	ENOG4105D7Z	glutathione synthase
WM2015_368	ENOG41067XB	TonB family
WM2015_369	ENOG4108UJU	UPF0301 protein
WM2015_370	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
WM2015_371	ENOG4105CXT	aspartate transcarbamylase
WM2015_372	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
WM2015_377	ENOG4108JPZ	Monovalent cation H antiporter subunit D
WM2015_379	ENOG4108JPZ	Monovalent cation H antiporter subunit D
WM2015_380	ENOG4108JPZ	Monovalent cation H antiporter subunit D
WM2015_381	ENOG4105MKQ	Monovalent cation H antiporter subunit C
WM2015_384	ENOG4105KJM	monovalent cation h antiporter subunit g
WM2015_387	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
WM2015_388	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
WM2015_389	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
WM2015_39	ENOG4105VEQ	Cold shock protein
WM2015_390	ENOG4105SYT	Methylenetetrahydrofolate reductase
WM2015_392	ENOG4105D44	asparaginase
WM2015_394	ENOG4108YZ4	nudix hydrolase
WM2015_396	ENOG4105C2M	dna polymerase I
WM2015_398	ENOG4105C0H	protease
WM2015_399	ENOG4107RY6	amino acid
WM2015_4	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
WM2015_400	ENOG4105CSR	polyphosphate kinase 2
WM2015_402	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
WM2015_404	ENOG4105CTB	Polyprenyl synthetase
WM2015_405	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WM2015_406	ENOG4105C34	Pseudouridine synthase
WM2015_407	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
WM2015_408	ENOG4105CBC	glutamate synthase
WM2015_41	ENOG4105DY8	decarboxylase
WM2015_410	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
WM2015_411	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
WM2015_412	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
WM2015_413	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
WM2015_415	ENOG4107QKW	extracellular solute-binding protein family 1
WM2015_417	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
WM2015_418	ENOG4105HDK	L-asparaginase
WM2015_421	ENOG4105CS1	NAD(P)H quinone oxidoreductase
WM2015_422	ENOG4105K89	arsenate reductase
WM2015_423	ENOG4107S2Z	UPF0761 membrane protein
WM2015_424	ENOG4108IFH	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WM2015_428	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
WM2015_430	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
WM2015_431	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
WM2015_432	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
WM2015_434	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WM2015_435	ENOG4105DZP	Membrane-associated zinc metalloprotease
WM2015_436	ENOG4105KNE	Phosphatidate cytidylyltransferase
WM2015_437	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
WM2015_438	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
WM2015_439	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
WM2015_44	ENOG4105BZU	Histidine kinase
WM2015_440	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
WM2015_441	ENOG4105CE9	30S ribosomal protein S2
WM2015_442	ENOG4105C72	UPF0176 protein
WM2015_443	ENOG4105EGS	Mechanosensitive ion channel
WM2015_444	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
WM2015_446	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
WM2015_465	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
WM2015_467	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
WM2015_474	ENOG4109015	Biopolymer transport protein exbD tolR
WM2015_478	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
WM2015_479	ENOG4105T95	Thiol disulfide interChange protein
WM2015_480	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
WM2015_482	ENOG4107QHF	type ii secretion system protein e
WM2015_483	ENOG4105D7Q	type ii secretion system
WM2015_485	ENOG4105WMT	general secretion pathway protein h
WM2015_488	ENOG4105UV2	general secretion pathway protein K
WM2015_492	ENOG4105GVR	general secretion pathway protein D
WM2015_496	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
WM2015_504	ENOG4105C5H	ABC transporter
WM2015_505	ENOG4107VBM	3-beta hydroxysteroid dehydrogenase isomerase
WM2015_508	ENOG4105C9M	aspartyl-trna synthetase
WM2015_511	ENOG4105CDY	transcriptional regulatory protein
WM2015_512	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
WM2015_513	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
WM2015_515	ENOG4107YD3	Thioesterase
WM2015_516	ENOG4105E02	MotA TolQ exbB proton channel
WM2015_517	ENOG4105M8F	Biopolymer transport protein exbD tolR
WM2015_52	ENOG4105E3A	(ABC) transporter
WM2015_520	ENOG4105KCK	Peptidoglycan-associated lipoprotein
WM2015_522	ENOG4107VRB	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
WM2015_523	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
WM2015_524	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
WM2015_525	ENOG4105C11	sulfate adenylyltransferase), subunit 2
WM2015_528	ENOG4105C1V	Peptidase, M16
WM2015_53	ENOG4105DA5	(ABC) transporter
WM2015_530	ENOG4105E0X	reductase
WM2015_531	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
WM2015_532	ENOG4105DAN	ATP-dependent protease
WM2015_534	ENOG4105CFH	Aspartokinase
WM2015_537	ENOG4105D9P	serine threonine protein kinase
WM2015_538	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
WM2015_539	ENOG4105FDS	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
WM2015_542	ENOG4105C5H	ABC transporter
WM2015_544	ENOG4108FUT	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
WM2015_545	ENOG4105VEQ	Cold shock protein
WM2015_548	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
WM2015_550	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
WM2015_554	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
WM2015_555	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
WM2015_557	ENOG4108VAU	general secretion pathway protein G
WM2015_558	ENOG4105VWV	general secretion pathway protein h
WM2015_559	ENOG4105X5Z	General secretion pathway protein I
WM2015_560	ENOG4108WWZ	General secretion pathway protein J
WM2015_565	ENOG4107TK4	histidinol-phosphate phosphatase
WM2015_566	ENOG4107RK2	ADP-ribose diphosphatase NudE
WM2015_568	ENOG4108YXA	Membrane
WM2015_569	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
WM2015_570	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
WM2015_574	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
WM2015_576	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
WM2015_579	ENOG4105E18	UPF0276 protein
WM2015_581	ENOG4109045	doxx family
WM2015_582	ENOG4105C8T	Leucyl-tRNA synthetase
WM2015_585	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
WM2015_588	ENOG4108Z03	MAF-like protein
WM2015_589	ENOG4105C03	ribonuclease
WM2015_591	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
WM2015_592	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
WM2015_595	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
WM2015_597	ENOG4105CP7	Triose-phosphate isomerase
WM2015_598	ENOG4107EJC	Preprotein translocase subunit SecG
WM2015_599	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WM2015_6	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
WM2015_600	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
WM2015_601	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WM2015_602	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
WM2015_604	ENOG4107QIZ	NADH dehydrogenase
WM2015_606	ENOG4108IEH	NADH dehydrogenase subunit g
WM2015_607	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
WM2015_608	ENOG41081XG	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
WM2015_609	ENOG4105DF2	NADH dehydrogenase subunit j
WM2015_610	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
WM2015_612	ENOG4105C8S	subunit m
WM2015_614	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
WM2015_615	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
WM2015_616	ENOG41072GX	Peptidase M22 Glycoprotease
WM2015_619	ENOG4105CMM	transposase
WM2015_622	ENOG4105DVT	helicase
WM2015_624	ENOG4105BZ4	penicillin-binding protein
WM2015_628	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
WM2015_63	ENOG4105CP2	von willebrand factor, type a
WM2015_634	ENOG4105CQ7	ATP-dependent helicase
WM2015_635	ENOG4105C5W	Aldolase
WM2015_636	ENOG4108IUZ	ABC transporter
WM2015_639	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
WM2015_640	ENOG4105C2X	Arabinose 5-phosphate isomerase
WM2015_643	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
WM2015_644	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
WM2015_645	ENOG4105DFG	type I secretion outer membrane protein
WM2015_646	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
WM2015_647	ENOG4105D1S	lipid A biosynthesis
WM2015_648	ENOG4106WTF	Glycosyl transferase, family 2
WM2015_650	ENOG4105C8V	SAICAR synthetase
WM2015_651	ENOG4105DJV	ribulose-phosphate 3-epimerase
WM2015_653	ENOG4105CRQ	synthase (Component I)
WM2015_654	ENOG4105DDQ	anthranilate synthase
WM2015_655	ENOG4107QYG	anthranilate phosphoribosyltransferase
WM2015_656	ENOG4105DK0	Indole-3-glycerol phosphate synthase
WM2015_657	ENOG4108EX3	reductase
WM2015_662	ENOG4106ZX3	phosphonate ABC transporter, periplasmic phosphonate-binding protein
WM2015_663	ENOG4105D5T	phosphonate abc transporter
WM2015_669	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
WM2015_670	ENOG4108UJD	30S ribosomal protein S9
WM2015_674	ENOG4105BZU	Histidine kinase
WM2015_675	ENOG4105WH1	Two component transcriptional regulator luxr family
WM2015_676	ENOG4105IIU	Aminopeptidase
WM2015_682	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
WM2015_683	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
WM2015_684	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
WM2015_685	ENOG4105KUZ	arsenate reductase
WM2015_686	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
WM2015_691	ENOG4107RDJ	Sulfotransferase
WM2015_696	ENOG4105CBX	hi0933 family
WM2015_699	ENOG4105D9P	serine threonine protein kinase
WM2015_7	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
WM2015_708	ENOG4105DGW	oligopeptidase A
WM2015_71	ENOG4105CI2	imidazolone-5-propionate hydrolase
WM2015_717	ENOG4105BZU	Histidine kinase
WM2015_719	ENOG4105CK2	sodium dicarboxylate symporter
WM2015_723	ENOG4105C0D	helicase
WM2015_726	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
WM2015_728	ENOG4105CSR	polyphosphate kinase 2
WM2015_730	ENOG4105D9P	serine threonine protein kinase
WM2015_739	ENOG4105J8Z	peptidase S8 and S53, subtilisin, kexin, sedolisin
WM2015_744	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
WM2015_745	ENOG4107UU3	sucrose-phosphate synthase (EC 2.4.1.14)
WM2015_749	ENOG4105CRW	Short chain fatty acid transporter
WM2015_750	ENOG4105FQP	Beta-lactamase
WM2015_751	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
WM2015_755	ENOG4107S9D	Alpha beta hydrolase
WM2015_757	ENOG4105NXH	GreA GreB family elongation factor
WM2015_760	ENOG4105F64	nitrite reductase
WM2015_761	ENOG4107ENK	receptor
WM2015_763	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
WM2015_764	ENOG4108VGI	doxx family
WM2015_765	ENOG4105CBN	LysR family transcriptional regulator
WM2015_768	ENOG4105WCN	acetyltransferase
WM2015_780	ENOG4105E3J	oxidoreductase
WM2015_782	ENOG4105CHF	Glutathione S-transferase
WM2015_785	ENOG4105D9P	serine threonine protein kinase
WM2015_795	ENOG4105MRD	Phage derived protein Gp49-like (DUF891)
WM2015_8	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
WM2015_807	ENOG4105VMP	Transcriptional regulator
WM2015_811	ENOG4108A04	Beta-lactamase
WM2015_82	ENOG4108HRK	Histidine kinase
WM2015_823	ENOG4108V9Q	carbonic anhydrase
WM2015_824	ENOG4108YAB	Invasion protein
WM2015_83	ENOG4108VAC	response regulator
WM2015_839	ENOG4107ZSV	Receptor
WM2015_84	ENOG4105CNG	UPF0061 protein
WM2015_843	ENOG4105D9P	serine threonine protein kinase
WM2015_844	ENOG4105BZS	acriflavin resistance protein
WM2015_845	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
WM2015_847	ENOG4105C94	Transporter
WM2015_848	ENOG4105C94	Transporter
WM2015_85	ENOG410906A	Beta-Ig-H3 fasciclin
WM2015_850	ENOG4108WBT	adenosyltransferase
WM2015_859	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
WM2015_86	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
WM2015_861	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
WM2015_864	ENOG4107TVC	Glycosyl transferase, family 2
WM2015_866	ENOG4105BZS	acriflavin resistance protein
WM2015_867	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
WM2015_869	ENOG4108IAJ	Nad-dependent epimerase dehydratase
WM2015_873	ENOG4105DHF	Membrane
WM2015_876	ENOG4105EQR	Transposase IS116 IS110 IS902
WM2015_887	ENOG4105CPQ	Dehydrogenase
WM2015_891	ENOG4105DP0	ferredoxin-NADP reductase
WM2015_90	ENOG4105CK7	Sodium proline symporter
WM2015_902	ENOG4105C8P	)-transporter
WM2015_903	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
WM2015_91	ENOG4105CM2	brancheD-chain amino acid aminotransferase
WM2015_910	ENOG4108IAB	Phoh family
WM2015_911	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WM2015_912	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
WM2015_914	ENOG4108Z4U	Ferredoxin
WM2015_915	ENOG4105DJ0	Poly(A) Polymerase
WM2015_916	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WM2015_917	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
WM2015_918	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
WM2015_928	ENOG4105N42	UPF0307 protein
WM2015_93	ENOG4107RE3	peptidase, S41
WM2015_931	ENOG4107QPV	Serine Threonine protein kinase
WM2015_935	ENOG4105CGZ	zinc metallopeptidase
WM2015_939	ENOG4108M15	ABC transporter
WM2015_941	ENOG4105CI2	imidazolone-5-propionate hydrolase
WM2015_942	ENOG4108ZGX	Histidine kinase
WM2015_943	ENOG4108S01	response regulator
WM2015_946	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
WM2015_949	ENOG41066YJ	Beta-lactamase
WM2015_95	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
WM2015_950	ENOG4105MGK	May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity)
WM2015_951	ENOG4107IFA	Lipase (EC 3.1.1.3)
WM2015_953	ENOG4105D9P	serine threonine protein kinase
WM2015_96	ENOG4105C19	ABC transporter
WM2015_960	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
WM2015_961	ENOG41080IJ	Diacylglycerol kinase
WM2015_962	ENOG4105DGW	oligopeptidase A
WM2015_963	ENOG4105CHM	Aminotransferase
WM2015_964	ENOG4105M2J	Glutaredoxin
WM2015_966	ENOG4105CD5	CoA-binding domain protein
WM2015_967	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
WM2015_968	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
WM2015_969	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
WM2015_97	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
WM2015_973	ENOG4105BZU	Histidine kinase
WM2015_978	ENOG4107YB6	acetyltransferase, (GNAT) family
WM2015_984	ENOG4105CHR	reductase
WM2015_987	ENOG4105CYC	Transferase