locus-tag	class	description
WM2015_1	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WM2015_10	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
WM2015_1002	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WM2015_1005	COG0745	RESPONSE REGULATOR receiver
WM2015_1006	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WM2015_1010	COG1201	RNA secondary structure unwinding
WM2015_1011	COG1793	dna ligase
WM2015_1014	COG1506	peptidase
WM2015_1014	COG0823	Involved in the tonB-independent uptake of proteins
WM2015_1014	COG4946	Tricorn protease homolog
WM2015_1017	COG5505	Protein of unknown function (DUF819)
WM2015_1022	COG2239	Acts as a magnesium transporter
WM2015_103	COG0436	Aminotransferase
WM2015_1031	COG0493	'glutamate synthase
WM2015_1032	COG0069	glutamate synthase activity
WM2015_1032	COG0067	glutamate synthase
WM2015_1032	COG0070	glutamate synthase
WM2015_1033	COG4243	Vitamin k epoxide reductase
WM2015_1037	COG0492	ferredoxin-NADP+ reductase activity
WM2015_1038	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WM2015_104	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
WM2015_1040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WM2015_1041	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WM2015_1042	COG0006	proline dipeptidase activity
WM2015_1045	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
WM2015_1046	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WM2015_1048	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WM2015_105	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
WM2015_1050	COG3706	GGDEF domain
WM2015_1051	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WM2015_1052	COG1834	amidinotransferase
WM2015_1054	COG0745	RESPONSE REGULATOR receiver
WM2015_1055	COG2205	protein histidine kinase activity
WM2015_1056	COG3956	TIGRFAM MazG family protein
WM2015_1058	COG4106	trans-aconitate 2-methyltransferase activity
WM2015_106	COG0235	Class ii aldolase
WM2015_1065	COG2183	response to ionizing radiation
WM2015_1068	COG1404	Belongs to the peptidase S8 family
WM2015_1071	COG0545	Peptidyl-prolyl cis-trans isomerase
WM2015_1072	COG0515	serine threonine protein kinase
WM2015_1072	COG2815	serine threonine protein kinase
WM2015_1081	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WM2015_1090	COG1024	Enoyl-CoA hydratase
WM2015_1091	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WM2015_1093	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WM2015_1094	COG1185	polyribonucleotide nucleotidyltransferase activity
WM2015_1097	COG0859	PFAM glycosyl transferase family 9
WM2015_11	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
WM2015_1102	COG0697	spore germination
WM2015_1104	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
WM2015_1105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WM2015_1107	COG2166	iron-sulfur cluster assembly
WM2015_1108	COG0215	cysteine-tRNA ligase activity
WM2015_1115	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WM2015_1116	COG2828	Protein conserved in bacteria
WM2015_112	COG1228	amidohydrolase
WM2015_1121	COG0823	Involved in the tonB-independent uptake of proteins
WM2015_1128	COG0655	NAD(P)H dehydrogenase (quinone) activity
WM2015_1129	COG0583	DNA-binding transcription factor activity
WM2015_1131	COG0697	spore germination
WM2015_114	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WM2015_115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WM2015_1152	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WM2015_1154	COG3119	arylsulfatase activity
WM2015_116	COG2003	Belongs to the UPF0758 family
WM2015_1162	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WM2015_117	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WM2015_1175	COG1506	peptidase
WM2015_1175	COG0823	Involved in the tonB-independent uptake of proteins
WM2015_118	COG0756	dUTP diphosphatase activity
WM2015_1182	COG1288	antiporter activity
WM2015_1188	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WM2015_119	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WM2015_1196	COG0714	Associated with various cellular activities
WM2015_1203	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WM2015_1207	COG0604	alcohol dehydrogenase
WM2015_1211	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WM2015_1211	COG1017	nitric oxide dioxygenase activity
WM2015_1212	COG1309	transcriptional regulator
WM2015_1213	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WM2015_1222	COG3706	GGDEF domain
WM2015_1223	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WM2015_1230	COG1960	acyl-CoA dehydrogenase activity
WM2015_1235	COG0640	Transcriptional regulator
WM2015_1236	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WM2015_1236	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WM2015_1236	COG1703	isobutyryl-CoA mutase activity
WM2015_1239	COG3104	oligopeptide transport
WM2015_124	COG0601	transmembrane transport
WM2015_1240	COG0587	DNA-directed DNA polymerase activity
WM2015_1242	COG0515	serine threonine protein kinase
WM2015_1248	COG2205	protein histidine kinase activity
WM2015_1249	COG0745	RESPONSE REGULATOR receiver
WM2015_125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WM2015_1251	COG2304	oxidoreductase activity
WM2015_1253	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WM2015_1257	COG2815	serine threonine protein kinase
WM2015_1257	COG0515	serine threonine protein kinase
WM2015_1262	COG0544	peptidyl-prolyl cis-trans isomerase activity
WM2015_1263	COG0740	serine-type endopeptidase activity
WM2015_1264	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WM2015_1267	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WM2015_1271	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WM2015_1271	COG0515	serine threonine protein kinase
WM2015_1272	COG3064	Membrane
WM2015_1274	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WM2015_1276	COG3046	protein related to deoxyribodipyrimidine photolyase
WM2015_128	COG4608	Belongs to the ABC transporter superfamily
WM2015_1282	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WM2015_1283	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WM2015_1287	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WM2015_1293	COG2878	Part of a membrane complex involved in electron transport
WM2015_1296	COG4657	Part of a membrane complex involved in electron transport
WM2015_1297	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WM2015_1297	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WM2015_1300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WM2015_1302	COG0723	plastoquinol--plastocyanin reductase activity
WM2015_1303	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WM2015_1304	COG2857	Cytochrome c1
WM2015_1305	COG0625	glutathione transferase activity
WM2015_1306	COG2969	positive regulation of protein catabolic process
WM2015_1309	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WM2015_131	COG1192	Involved in chromosome partitioning
WM2015_1311	COG1238	metal cluster binding
WM2015_1313	COG1959	2 iron, 2 sulfur cluster binding
WM2015_1314	COG0860	N-Acetylmuramoyl-L-alanine amidase
WM2015_1315	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WM2015_1316	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WM2015_1317	COG1923	regulation of RNA biosynthetic process
WM2015_1318	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WM2015_1319	COG0330	HflC and HflK could
WM2015_132	COG1475	DNA binding
WM2015_1320	COG0330	HflC and HflK could
WM2015_1321	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WM2015_1322	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WM2015_1323	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WM2015_1325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WM2015_1326	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WM2015_1327	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WM2015_1328	COG0539	negative regulation of cytoplasmic translation
WM2015_1329	COG0776	regulation of translation
WM2015_133	COG5000	phosphorelay sensor kinase activity
WM2015_1331	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
WM2015_1332	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WM2015_1338	COG1960	acyl-CoA dehydrogenase activity
WM2015_1339	COG0508	dehydrogenase complex catalyzes the overall conversion of
WM2015_1339	COG0022	dehydrogenase e1 component
WM2015_1340	COG4943	cyclic-guanylate-specific phosphodiesterase activity
WM2015_1343	COG0156	8-amino-7-oxononanoate synthase activity
WM2015_1344	COG1063	alcohol dehydrogenase
WM2015_1348	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WM2015_135	COG1136	(ABC) transporter
WM2015_135	COG0577	efflux transmembrane transporter activity
WM2015_1351	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WM2015_1352	COG1472	Belongs to the glycosyl hydrolase 3 family
WM2015_1353	COG0668	transmembrane transport
WM2015_136	COG0577	efflux transmembrane transporter activity
WM2015_1360	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WM2015_1361	COG1546	Belongs to the CinA family
WM2015_1362	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
WM2015_1363	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WM2015_1364	COG2137	regulation of response to DNA damage stimulus
WM2015_1365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WM2015_1366	COG0662	Cupin 2, conserved barrel domain protein
WM2015_1367	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WM2015_1368	COG0516	GMP reductase activity
WM2015_1368	COG0517	IMP dehydrogenase activity
WM2015_1369	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WM2015_1369	COG0519	Catalyzes the synthesis of GMP from XMP
WM2015_137	COG1136	(ABC) transporter
WM2015_137	COG0577	efflux transmembrane transporter activity
WM2015_1370	COG0590	tRNA wobble adenosine to inosine editing
WM2015_1373	COG1960	acyl-CoA dehydrogenase activity
WM2015_1374	COG2902	Dehydrogenase
WM2015_1375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WM2015_1378	COG0402	S-adenosylhomocysteine deaminase activity
WM2015_1381	COG3706	GGDEF domain
WM2015_1382	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WM2015_1383	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WM2015_1386	COG4943	cyclic-guanylate-specific phosphodiesterase activity
WM2015_1389	COG3590	peptidase
WM2015_1390	COG3437	response regulator, receiver
WM2015_1390	COG2770	Histidine kinase
WM2015_1393	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WM2015_1394	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WM2015_1395	COG4988	ABC transporter
WM2015_1396	COG1294	oxidase, subunit
WM2015_1397	COG1271	oxidase subunit
WM2015_1398	COG0432	Pfam Uncharacterised protein family UPF0047
WM2015_140	COG0300	oxidoreductase activity
WM2015_1400	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WM2015_1402	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WM2015_1403	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WM2015_1404	COG1288	antiporter activity
WM2015_1406	COG0626	cystathionine gamma-synthase activity
WM2015_1407	COG1522	sequence-specific DNA binding
WM2015_1413	COG2915	High frequency lysogenization protein hflD homolog
WM2015_1414	COG0482	sulfurtransferase activity
WM2015_1415	COG0583	DNA-binding transcription factor activity
WM2015_1416	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WM2015_1417	COG2224	Isocitrate lyase
WM2015_1418	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WM2015_1419	COG0542	response to heat
WM2015_142	COG0356	it plays a direct role in the translocation of protons across the membrane
WM2015_1420	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WM2015_1421	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
WM2015_1424	COG2235	arginine
WM2015_1425	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WM2015_1428	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WM2015_1429	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WM2015_1430	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
WM2015_1431	COG0114	fumarate hydratase activity
WM2015_1432	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WM2015_1433	COG0071	Belongs to the small heat shock protein (HSP20) family
WM2015_1438	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WM2015_144	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WM2015_1440	COG0492	ferredoxin-NADP+ reductase activity
WM2015_1441	COG0686	Belongs to the AlaDH PNT family
WM2015_1442	COG1674	ftsk spoiiie
WM2015_1443	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WM2015_1449	COG1132	(ABC) transporter
WM2015_145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WM2015_1453	COG2197	response regulator
WM2015_146	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WM2015_1461	COG0662	Cupin 2, conserved barrel domain protein
WM2015_1465	COG0017	Asparaginyl-tRNA synthetase
WM2015_1466	COG0316	Belongs to the HesB IscA family
WM2015_1468	COG0360	Binds together with S18 to 16S ribosomal RNA
WM2015_1469	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WM2015_147	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WM2015_1471	COG0305	Participates in initiation and elongation during chromosome replication
WM2015_1472	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WM2015_1473	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WM2015_1474	COG1702	phosphate starvation-inducible protein PhoH
WM2015_1475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WM2015_1476	COG4535	Mg2 and Co2 transporter CorC
WM2015_148	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WM2015_1482	COG1064	alcohol dehydrogenase
WM2015_1484	COG3228	Belongs to the MtfA family
WM2015_1485	COG1022	Amp-dependent synthetase and ligase
WM2015_149	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WM2015_1490	COG0463	Glycosyl transferase, family 2
WM2015_1493	COG0531	amino acid
WM2015_15	COG0500	methyltransferase
WM2015_150	COG1404	Belongs to the peptidase S8 family
WM2015_1501	COG3710	Transcriptional regulator
WM2015_1503	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WM2015_1505	COG1047	Peptidyl-prolyl cis-trans
WM2015_1506	COG1850	ribulose-bisphosphate carboxylase activity
WM2015_1513	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
WM2015_1519	COG4946	Tricorn protease homolog
WM2015_1519	COG0793	Belongs to the peptidase S41A family
WM2015_1520	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WM2015_1520	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WM2015_1521	COG0109	protoheme IX farnesyltransferase activity
WM2015_1522	COG1612	heme a metabolic process
WM2015_1526	COG0678	peroxiredoxin activity
WM2015_1526	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WM2015_1528	COG0604	alcohol dehydrogenase
WM2015_1532	COG2850	peptidyl-arginine hydroxylation
WM2015_1535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WM2015_1539	COG1162	GTPase activity
WM2015_154	COG0037	tRNA processing
WM2015_1540	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WM2015_1542	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WM2015_1544	COG0505	Belongs to the CarA family
WM2015_1545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WM2015_1546	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WM2015_1548	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WM2015_1550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WM2015_1553	COG0124	histidyl-tRNA synthetase
WM2015_1554	COG2976	Protein conserved in bacteria
WM2015_1555	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WM2015_1556	COG1160	GTP binding
WM2015_1557	COG0386	Belongs to the glutathione peroxidase family
WM2015_1558	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WM2015_156	COG2937	Belongs to the GPAT DAPAT family
WM2015_1560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
WM2015_1563	COG0183	Belongs to the thiolase family
WM2015_1565	COG0424	maF-like protein
WM2015_1566	COG1399	metal-binding, possibly nucleic acid-binding protein
WM2015_1567	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WM2015_1569	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WM2015_157	COG0284	orotidine-5'-phosphate decarboxylase activity
WM2015_1572	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WM2015_1573	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WM2015_1574	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WM2015_1575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WM2015_1576	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WM2015_1577	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WM2015_158	COG0596	Alpha beta hydrolase
WM2015_1580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WM2015_1581	COG0318	PFAM AMP-dependent synthetase and ligase
WM2015_1584	COG1201	RNA secondary structure unwinding
WM2015_1586	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WM2015_1588	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WM2015_1589	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WM2015_159	COG0210	DNA helicase
WM2015_1592	COG3267	Type II secretory pathway component ExeA
WM2015_1592	COG3409	Peptidoglycan-binding domain 1 protein
WM2015_1596	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
WM2015_1597	COG2861	carbohydrate metabolic process
WM2015_1598	COG0793	Belongs to the peptidase S41A family
WM2015_1599	COG4942	peptidase
WM2015_160	COG0151	Belongs to the GarS family
WM2015_1600	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WM2015_1601	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WM2015_1602	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WM2015_1603	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WM2015_1604	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WM2015_1605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WM2015_161	COG0138	bifunctional purine biosynthesis protein purh
WM2015_1619	COG1757	Na H antiporter
WM2015_1621	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
WM2015_1623	COG0326	Molecular chaperone. Has ATPase activity
WM2015_1628	COG0336	Belongs to the RNA methyltransferase TrmD family
WM2015_1629	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WM2015_1630	COG0228	four-way junction DNA binding
WM2015_1633	COG0405	Gamma-glutamyltransferase
WM2015_1634	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WM2015_1635	COG0742	ribosomal rna small subunit methyltransferase
WM2015_1636	COG0552	protein localization to endoplasmic reticulum
WM2015_1637	COG1194	a g-specific adenine glycosylase
WM2015_1639	COG4585	Histidine kinase
WM2015_1641	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
WM2015_1643	COG2890	protein-(glutamine-N5) methyltransferase activity
WM2015_1645	COG0237	dephospho-CoA kinase activity
WM2015_1646	COG0589	response to stress
WM2015_1647	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WM2015_165	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WM2015_1650	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WM2015_1653	COG2350	Protein conserved in bacteria
WM2015_1654	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WM2015_1655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WM2015_1658	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WM2015_1659	COG0557	exoribonuclease II activity
WM2015_166	COG1136	(ABC) transporter
WM2015_1660	COG1388	LysM domain
WM2015_1660	COG0741	lytic transglycosylase activity
WM2015_1663	COG1469	GTP cyclohydrolase I activity
WM2015_1665	COG0776	regulation of translation
WM2015_1666	COG0072	phenylalanine-tRNA ligase activity
WM2015_1666	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WM2015_1669	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WM2015_1670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WM2015_1671	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WM2015_1677	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WM2015_1682	COG0513	Belongs to the DEAD box helicase family
WM2015_1683	COG0500	methyltransferase
WM2015_1686	COG1253	flavin adenine dinucleotide binding
WM2015_1687	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WM2015_169	COG0457	Tetratricopeptide repeat
WM2015_1690	COG4946	Tricorn protease homolog
WM2015_1690	COG0823	Involved in the tonB-independent uptake of proteins
WM2015_1690	COG1506	peptidase
WM2015_1691	COG0277	FAD linked oxidase domain protein
WM2015_1692	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WM2015_1694	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WM2015_1695	COG0714	Associated with various cellular activities
WM2015_1696	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WM2015_1697	COG0537	adenosine 5'-monophosphoramidase activity
WM2015_17	COG0733	neurotransmitter:sodium symporter activity
WM2015_170	COG0708	Exodeoxyribonuclease III
WM2015_1702	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WM2015_1705	COG0402	S-adenosylhomocysteine deaminase activity
WM2015_1706	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WM2015_1707	COG1509	lysine 2,3-aminomutase activity
WM2015_1709	COG0501	Belongs to the peptidase M48B family
WM2015_1710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WM2015_1712	COG0037	tRNA processing
WM2015_1719	COG0456	acetyltransferase
WM2015_1722	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WM2015_1723	COG0156	8-amino-7-oxononanoate synthase activity
WM2015_1724	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WM2015_1727	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WM2015_1728	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WM2015_1734	COG2133	pyrroloquinoline quinone binding
WM2015_1737	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WM2015_1737	COG3153	acetyltransferase
WM2015_1738	COG0438	transferase activity, transferring glycosyl groups
WM2015_1742	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WM2015_1743	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WM2015_1745	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WM2015_1748	COG1960	acyl-CoA dehydrogenase activity
WM2015_1749	COG1607	acyl-coa hydrolase
WM2015_1750	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WM2015_1751	COG0450	alkyl hydroperoxide reductase
WM2015_1752	COG0583	DNA-binding transcription factor activity
WM2015_1756	COG1131	(ABC) transporter
WM2015_1763	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WM2015_1764	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WM2015_1765	COG0372	Belongs to the citrate synthase family
WM2015_1766	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WM2015_1767	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WM2015_1767	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WM2015_1770	COG0714	Associated with various cellular activities
WM2015_1773	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WM2015_1774	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WM2015_1775	COG2833	Protein of unknown function (DUF455)
WM2015_178	COG4942	peptidase
WM2015_1785	COG0527	aspartate kinase activity
WM2015_1785	COG0460	homoserine dehydrogenase
WM2015_1786	COG0626	cystathionine gamma-synthase activity
WM2015_1787	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WM2015_179	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WM2015_1790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WM2015_1792	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WM2015_1794	COG4221	oxidoreductase activity
WM2015_1802	COG3483	tryptophan 2,3-dioxygenase activity
WM2015_1804	COG0022	dehydrogenase e1 component
WM2015_1805	COG0508	dehydrogenase complex catalyzes the overall conversion of
WM2015_1806	COG4067	protein conserved in archaea
WM2015_1806	COG0189	ligase activity
WM2015_1807	COG0189	ligase activity
WM2015_1812	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WM2015_1813	COG2009	succinate dehydrogenase
WM2015_1814	COG5508	conserved small protein
WM2015_1819	COG0322	excinuclease ABC activity
WM2015_182	COG1592	Rubrerythrin
WM2015_1820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WM2015_1821	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WM2015_1823	COG1132	(ABC) transporter
WM2015_1824	COG0848	biopolymer transport protein
WM2015_1825	COG0811	peptide transport
WM2015_1826	COG0658	competence protein
WM2015_1826	COG2333	competence protein COMEC
WM2015_1827	COG1136	(ABC) transporter
WM2015_1828	COG4591	ABC-type transport system involved in lipoprotein release permease component
WM2015_1830	COG1530	ribonuclease E activity
WM2015_1832	COG0484	heat shock protein binding
WM2015_1834	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WM2015_1835	COG0497	DNA recombination
WM2015_1837	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WM2015_1838	COG2914	Belongs to the UPF0125 (RnfH) family
WM2015_184	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WM2015_1840	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WM2015_1841	COG0582	viral genome integration into host DNA
WM2015_1842	COG2801	Transposase and inactivated derivatives
WM2015_1845	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
WM2015_1846	COG2226	methyltransferase
WM2015_185	COG0137	argininosuccinate synthase activity
WM2015_1850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WM2015_1850	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WM2015_1851	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
WM2015_1852	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WM2015_1854	COG0704	Plays a role in the regulation of phosphate uptake
WM2015_1855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WM2015_1856	COG0573	inorganic phosphate transmembrane transporter activity
WM2015_1863	COG0848	biopolymer transport protein
WM2015_1864	COG0811	peptide transport
WM2015_1865	COG0811	peptide transport
WM2015_187	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WM2015_1870	COG0735	belongs to the Fur family
WM2015_1871	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WM2015_1872	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WM2015_1873	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WM2015_1874	COG0328	RNA-DNA hybrid ribonuclease activity
WM2015_1876	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WM2015_1884	COG4969	Belongs to the N-Me-Phe pilin family
WM2015_189	COG0165	Argininosuccinate lyase
WM2015_1892	COG3118	belongs to the thioredoxin family
WM2015_1893	COG0513	Belongs to the DEAD box helicase family
WM2015_1894	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WM2015_1897	COG1459	type II secretion system
WM2015_1899	COG2884	Cell division ATP-binding protein ftsE
WM2015_1900	COG2177	Part of the ABC transporter FtsEX involved in
WM2015_1901	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WM2015_1905	COG0642	Histidine kinase
WM2015_1906	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WM2015_1908	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WM2015_191	COG1301	dicarboxylic acid transport
WM2015_1915	COG1024	Enoyl-CoA hydratase
WM2015_1915	COG1250	3-hydroxyacyl-CoA dehydrogenase
WM2015_1916	COG0183	Belongs to the thiolase family
WM2015_192	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WM2015_1920	COG0515	serine threonine protein kinase
WM2015_1920	COG2815	serine threonine protein kinase
WM2015_1923	COG1960	acyl-CoA dehydrogenase activity
WM2015_1925	COG1946	Acyl-CoA thioesterase
WM2015_1928	COG3071	HemY protein
WM2015_1931	COG0181	hydroxymethylbilane synthase activity
WM2015_1935	COG4106	trans-aconitate 2-methyltransferase activity
WM2015_1936	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WM2015_1938	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
WM2015_1940	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WM2015_1941	COG1127	ABC transporter
WM2015_1942	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WM2015_1943	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WM2015_1947	COG3300	MHYT domain
WM2015_1947	COG5001	Diguanylate cyclase
WM2015_1948	COG0640	Transcriptional regulator
WM2015_1950	COG0646	methionine synthase
WM2015_1950	COG1410	methionine synthase
WM2015_1955	COG1131	(ABC) transporter
WM2015_1959	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WM2015_196	COG1970	mechanosensitive ion channel activity
WM2015_1963	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
WM2015_1968	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WM2015_1968	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WM2015_1969	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WM2015_1977	COG0039	L-malate dehydrogenase activity
WM2015_1978	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
WM2015_1981	COG1012	belongs to the aldehyde dehydrogenase family
WM2015_1984	COG1597	lipid kinase activity
WM2015_1985	COG4771	TonB-dependent receptor
WM2015_1990	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WM2015_1992	COG1902	pentaerythritol trinitrate reductase activity
WM2015_1992	COG0446	pyridine nucleotide-disulphide oxidoreductase
WM2015_1993	COG2133	pyrroloquinoline quinone binding
WM2015_1994	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WM2015_1995	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WM2015_1996	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WM2015_2008	COG1842	Phage shock protein A
WM2015_201	COG0745	RESPONSE REGULATOR receiver
WM2015_2012	COG1024	Enoyl-CoA hydratase
WM2015_2017	COG1091	dTDP-4-dehydrorhamnose reductase activity
WM2015_2022	COG0142	geranyltranstransferase activity
WM2015_2027	COG0473	3-isopropylmalate dehydrogenase activity
WM2015_203	COG4946	Tricorn protease homolog
WM2015_203	COG1506	peptidase
WM2015_203	COG0823	Involved in the tonB-independent uptake of proteins
WM2015_2031	COG4783	chaperone-mediated protein folding
WM2015_2032	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WM2015_2033	COG0248	Ppx GppA phosphatase
WM2015_2034	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
WM2015_2037	COG0415	Belongs to the DNA photolyase family
WM2015_204	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WM2015_2040	COG1286	toxin biosynthetic process
WM2015_2042	COG0285	dihydrofolate synthase activity
WM2015_2043	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WM2015_2044	COG0159	tryptophan synthase activity
WM2015_2045	COG0133	tryptophan synthase activity
WM2015_2046	COG0135	phosphoribosylanthranilate isomerase activity
WM2015_2047	COG0101	tRNA pseudouridine synthase activity
WM2015_2049	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WM2015_205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM2015_2050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WM2015_2053	COG4181	ATPase activity
WM2015_2058	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WM2015_206	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WM2015_2063	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WM2015_2064	COG0339	signal peptide processing
WM2015_2065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WM2015_2066	COG4137	Cytochrome C assembly protein
WM2015_2067	COG4536	flavin adenine dinucleotide binding
WM2015_207	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
WM2015_2071	COG1381	Involved in DNA repair and RecF pathway recombination
WM2015_2073	COG0571	ribonuclease III activity
WM2015_2075	COG0681	Belongs to the peptidase S26 family
WM2015_2076	COG0481	GTPase activity
WM2015_2077	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WM2015_208	COG3458	cephalosporin-C deacetylase activity
WM2015_2082	COG1012	belongs to the aldehyde dehydrogenase family
WM2015_2083	COG0167	dihydroorotate dehydrogenase activity
WM2015_2087	COG1505	serine-type exopeptidase activity
WM2015_2090	COG0527	aspartate kinase activity
WM2015_2090	COG0460	homoserine dehydrogenase
WM2015_2092	COG2968	Membrane
WM2015_2093	COG2217	Heavy metal translocating P-type atpase
WM2015_2111	COG2986	histidine ammonia-lyase
WM2015_2112	COG1228	amidohydrolase
WM2015_2117	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WM2015_2118	COG1862	Preprotein translocase
WM2015_212	COG0625	glutathione transferase activity
WM2015_2122	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WM2015_2124	COG0515	serine threonine protein kinase
WM2015_2124	COG2815	serine threonine protein kinase
WM2015_2126	COG0343	queuine tRNA-ribosyltransferase activity
WM2015_2127	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WM2015_2131	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WM2015_2135	COG1404	Belongs to the peptidase S8 family
WM2015_2137	COG4133	protoheme IX ABC transporter activity
WM2015_2138	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WM2015_2139	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WM2015_214	COG1733	regulation of RNA biosynthetic process
WM2015_2141	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WM2015_2142	COG1138	Cytochrome C-type biogenesis protein
WM2015_2143	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WM2015_2146	COG1392	Phosphate transport regulator
WM2015_2147	COG0306	phosphate transporter
WM2015_2152	COG0268	Binds directly to 16S ribosomal RNA
WM2015_2153	COG0589	response to stress
WM2015_2154	COG0741	lytic transglycosylase activity
WM2015_2155	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_2157	COG2925	Exonuclease
WM2015_2159	COG1555	photosystem II stabilization
WM2015_2159	COG1596	polysaccharide export
WM2015_216	COG0515	serine threonine protein kinase
WM2015_2160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WM2015_2161	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WM2015_2162	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WM2015_2163	COG1404	Belongs to the peptidase S8 family
WM2015_2164	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WM2015_2165	COG1704	LemA family
WM2015_2169	COG3318	Belongs to the UPF0149 family
WM2015_2169	COG3012	SEC-C Motif Domain Protein
WM2015_2179	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM2015_2190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WM2015_2194	COG0653	protein targeting
WM2015_2197	COG1671	Belongs to the UPF0178 family
WM2015_2199	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WM2015_22	COG0823	Involved in the tonB-independent uptake of proteins
WM2015_22	COG1506	peptidase
WM2015_2204	COG0183	Belongs to the thiolase family
WM2015_2209	COG0668	transmembrane transport
WM2015_2212	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WM2015_2218	COG0515	serine threonine protein kinase
WM2015_2224	COG0688	phosphatidylethanolamine metabolic process
WM2015_2227	COG2738	Putative neutral zinc metallopeptidase
WM2015_223	COG1024	Enoyl-CoA hydratase
WM2015_2230	COG0792	nuclease activity
WM2015_2232	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WM2015_2234	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WM2015_2235	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WM2015_2238	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WM2015_2238	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WM2015_2239	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WM2015_2240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WM2015_2243	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WM2015_2246	COG2197	response regulator
WM2015_2247	COG3239	Fatty acid desaturase
WM2015_2251	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WM2015_2254	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WM2015_2255	COG4464	protein tyrosine phosphatase activity
WM2015_2258	COG1272	protein, Hemolysin III
WM2015_226	COG1077	Cell shape determining protein MreB Mrl
WM2015_2260	COG1132	(ABC) transporter
WM2015_2261	COG2962	Rard protein
WM2015_2263	COG0203	ribosomal protein L17
WM2015_2264	COG0202	RNA polymerase activity
WM2015_2266	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WM2015_2267	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WM2015_2268	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WM2015_2269	COG0201	protein transport
WM2015_227	COG1792	Involved in formation and maintenance of cell shape
WM2015_2270	COG0200	Binds to the 23S rRNA
WM2015_2271	COG1841	ribosomal large subunit assembly
WM2015_2272	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WM2015_2274	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WM2015_2275	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WM2015_2276	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WM2015_2277	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WM2015_2278	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WM2015_2279	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WM2015_2280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WM2015_2281	COG0255	Belongs to the universal ribosomal protein uL29 family
WM2015_2282	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WM2015_2283	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WM2015_2284	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WM2015_2285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WM2015_2286	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WM2015_2287	COG0089	rRNA binding
WM2015_2288	COG0088	Forms part of the polypeptide exit tunnel
WM2015_2289	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WM2015_229	COG0768	penicillin binding
WM2015_2290	COG0051	transcription antitermination factor activity, RNA binding
WM2015_2291	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WM2015_2292	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WM2015_2294	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WM2015_230	COG0772	Belongs to the SEDS family
WM2015_2302	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WM2015_2303	COG0085	RNA polymerase activity
WM2015_2304	COG0222	ribosome binding
WM2015_2305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WM2015_2306	COG0081	regulation of translation
WM2015_2307	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WM2015_2309	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WM2015_231	COG2951	lytic endotransglycosylase activity
WM2015_2310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WM2015_2311	COG0012	GTP binding
WM2015_2312	COG0193	aminoacyl-tRNA hydrolase activity
WM2015_2313	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WM2015_2317	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WM2015_2318	COG0196	riboflavin kinase activity
WM2015_2322	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_2327	COG2866	Carboxypeptidase
WM2015_2328	COG0564	pseudouridine synthase activity
WM2015_233	COG1686	Belongs to the peptidase S11 family
WM2015_2331	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WM2015_2336	COG0642	Histidine kinase
WM2015_2337	COG0745	RESPONSE REGULATOR receiver
WM2015_2338	COG0693	protein deglycase activity
WM2015_234	COG2921	Belongs to the UPF0250 family
WM2015_2344	COG0625	glutathione transferase activity
WM2015_2349	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
WM2015_235	COG0321	lipoyl(octanoyl) transferase activity
WM2015_2355	COG2091	lysine biosynthetic process via aminoadipic acid
WM2015_2356	COG0494	nUDIX hydrolase
WM2015_2357	COG0653	protein targeting
WM2015_2359	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WM2015_2363	COG1181	Belongs to the D-alanine--D-alanine ligase family
WM2015_2365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WM2015_2367	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WM2015_2368	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WM2015_2369	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WM2015_237	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WM2015_2371	COG3116	cell division
WM2015_2372	COG0275	rRNA processing
WM2015_2373	COG2001	Belongs to the MraZ family
WM2015_2375	COG1611	Belongs to the LOG family
WM2015_2379	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WM2015_2387	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WM2015_2388	COG0438	transferase activity, transferring glycosyl groups
WM2015_2389	COG3394	polysaccharide catabolic process
WM2015_239	COG0405	Gamma-glutamyltransferase
WM2015_2390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WM2015_2396	COG2244	polysaccharide biosynthetic process
WM2015_2397	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WM2015_2399	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WM2015_240	COG0254	rRNA binding
WM2015_2402	COG0489	protein tyrosine kinase activity
WM2015_2405	COG1943	Transposase
WM2015_2406	COG2198	Histidine kinase
WM2015_2406	COG2205	protein histidine kinase activity
WM2015_2406	COG0784	Response regulator, receiver
WM2015_2408	COG2610	gluconate transmembrane transporter activity
WM2015_2411	COG0626	cystathionine gamma-synthase activity
WM2015_2413	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WM2015_2414	COG0596	Alpha beta hydrolase
WM2015_2415	COG0318	PFAM AMP-dependent synthetase and ligase
WM2015_2419	COG0585	pseudouridine synthase activity
WM2015_2421	COG0745	RESPONSE REGULATOR receiver
WM2015_2423	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WM2015_2424	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WM2015_2428	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WM2015_2429	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WM2015_2431	COG1660	Displays ATPase and GTPase activities
WM2015_2432	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
WM2015_2434	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WM2015_2438	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WM2015_2439	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WM2015_2440	COG0195	Participates in both transcription termination and antitermination
WM2015_2440	COG2251	uridine kinase activity
WM2015_2448	COG4935	Belongs to the peptidase S8 family
WM2015_2448	COG2234	aminopeptidase activity
WM2015_2450	COG2815	serine threonine protein kinase
WM2015_2450	COG0515	serine threonine protein kinase
WM2015_2452	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WM2015_2453	COG0719	Fe-S assembly protein
WM2015_2454	COG0396	ATPase activity
WM2015_2456	COG0719	Fe-S assembly protein
WM2015_2457	COG1959	2 iron, 2 sulfur cluster binding
WM2015_2460	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WM2015_2463	COG0367	asparagine synthase
WM2015_2464	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WM2015_2465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WM2015_2468	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WM2015_2470	COG0501	Belongs to the peptidase M48B family
WM2015_2475	COG0308	aminopeptidase N
WM2015_2478	COG1956	GAF domain-containing protein
WM2015_248	COG4968	Prepilin-type N-terminal cleavage methylation domain
WM2015_2480	COG0402	S-adenosylhomocysteine deaminase activity
WM2015_2494	COG1115	amino acid carrier protein
WM2015_2497	COG0616	signal peptide processing
WM2015_2498	COG0534	Mate efflux family protein
WM2015_25	COG0626	cystathionine gamma-synthase activity
WM2015_2500	COG0515	serine threonine protein kinase
WM2015_2500	COG2815	serine threonine protein kinase
WM2015_2504	COG0745	RESPONSE REGULATOR receiver
WM2015_2506	COG3218	ABC-type transport auxiliary lipoprotein component
WM2015_2506	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WM2015_2507	COG1127	ABC transporter
WM2015_251	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WM2015_2510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WM2015_2513	COG1652	LysM domain
WM2015_2514	COG2198	Histidine kinase
WM2015_2514	COG2205	protein histidine kinase activity
WM2015_2514	COG0784	Response regulator, receiver
WM2015_2516	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WM2015_2520	COG2176	DNA-directed DNA polymerase activity
WM2015_2520	COG5002	protein histidine kinase activity
WM2015_2521	COG0517	IMP dehydrogenase activity
WM2015_2521	COG0516	GMP reductase activity
WM2015_2522	COG0515	serine threonine protein kinase
WM2015_253	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WM2015_2533	COG2945	thiolester hydrolase activity
WM2015_2534	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WM2015_2537	COG1960	acyl-CoA dehydrogenase activity
WM2015_2539	COG1477	protein flavinylation
WM2015_254	COG1561	YicC-like family, N-terminal region
WM2015_2540	COG3706	GGDEF domain
WM2015_2546	COG1051	belongs to the nudix hydrolase family
WM2015_2547	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WM2015_2548	COG1120	ATPase activity
WM2015_2549	COG2308	Evidence 4 Homologs of previously reported genes of
WM2015_255	COG0194	GDP metabolic process
WM2015_2553	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM2015_2555	COG5001	Diguanylate cyclase
WM2015_2555	COG3300	MHYT domain
WM2015_2556	COG0617	tRNA 3'-terminal CCA addition
WM2015_2558	COG0741	lytic transglycosylase activity
WM2015_2559	COG0730	response to heat
WM2015_256	COG1758	RNA polymerase activity
WM2015_2563	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WM2015_2565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WM2015_257	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WM2015_2573	COG0084	hydrolase, TatD family'
WM2015_2574	COG3256	nitric oxide reductase
WM2015_2575	COG2832	Protein of unknown function (DUF454)
WM2015_2577	COG1959	2 iron, 2 sulfur cluster binding
WM2015_2580	COG0848	biopolymer transport protein
WM2015_2581	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WM2015_2585	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WM2015_2587	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
WM2015_2589	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WM2015_2591	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_2597	COG2409	Drug exporters of the RND superfamily
WM2015_26	COG3706	GGDEF domain
WM2015_260	COG0473	3-isopropylmalate dehydrogenase activity
WM2015_2606	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
WM2015_2613	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WM2015_2614	COG2815	serine threonine protein kinase
WM2015_2614	COG0515	serine threonine protein kinase
WM2015_2617	COG0508	dehydrogenase complex catalyzes the overall conversion of
WM2015_2619	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
WM2015_2622	COG3588	fructose-bisphosphate aldolase
WM2015_2623	COG0469	pyruvate kinase activity
WM2015_2624	COG0625	glutathione transferase activity
WM2015_2626	COG2356	endonuclease I
WM2015_2629	COG5642	Protein of unknown function (DUF2384)
WM2015_2630	COG1476	TRANSCRIPTIONal
WM2015_264	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_2643	COG0463	Glycosyl transferase, family 2
WM2015_2649	COG0501	Belongs to the peptidase M48B family
WM2015_265	COG0586	Pfam SNARE associated Golgi protein
WM2015_2652	COG5001	Diguanylate cyclase
WM2015_2652	COG3300	MHYT domain
WM2015_266	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WM2015_2662	COG3425	synthase
WM2015_2668	COG4774	siderophore transport
WM2015_267	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WM2015_2672	COG2850	peptidyl-arginine hydroxylation
WM2015_2677	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WM2015_269	COG0425	Belongs to the sulfur carrier protein TusA family
WM2015_2690	COG1944	ATP diphosphatase activity
WM2015_2692	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WM2015_2693	COG3118	belongs to the thioredoxin family
WM2015_2702	COG0126	phosphoglycerate kinase activity
WM2015_2703	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WM2015_2704	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WM2015_2708	COG0642	Histidine kinase
WM2015_271	COG0205	6-phosphofructokinase activity
WM2015_2714	COG0762	integral membrane protein
WM2015_2719	COG0347	Belongs to the P(II) protein family
WM2015_272	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WM2015_2721	COG5002	protein histidine kinase activity
WM2015_2721	COG5001	Diguanylate cyclase
WM2015_2722	COG0606	chelatase, subunit chli
WM2015_2725	COG1575	Belongs to the MenA family. Type 1 subfamily
WM2015_273	COG0446	pyridine nucleotide-disulphide oxidoreductase
WM2015_2731	COG0519	Catalyzes the synthesis of GMP from XMP
WM2015_2737	COG3132	Protein of unknown function, DUF480
WM2015_2742	COG2199	diguanylate cyclase activity
WM2015_2742	COG2200	EAL domain
WM2015_2742	COG2203	Gaf domain
WM2015_2745	COG1160	GTP binding
WM2015_2747	COG3278	Belongs to the heme-copper respiratory oxidase family
WM2015_2750	COG2010	Cytochrome c
WM2015_2754	COG2217	Heavy metal translocating P-type atpase
WM2015_276	COG1595	DNA-templated transcription, initiation
WM2015_2763	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WM2015_2769	COG0174	glutamine synthetase
WM2015_2771	COG3852	Histidine kinase
WM2015_2772	COG2204	response regulator
WM2015_2773	COG1490	D-aminoacyl-tRNA deacylase activity
WM2015_2775	COG3360	Dodecin
WM2015_2776	COG0501	Belongs to the peptidase M48B family
WM2015_2777	COG1704	LemA family
WM2015_2782	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
WM2015_2785	COG2815	serine threonine protein kinase
WM2015_2785	COG0515	serine threonine protein kinase
WM2015_279	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WM2015_2793	COG3604	Transcriptional regulator
WM2015_2794	COG2815	serine threonine protein kinase
WM2015_2794	COG0515	serine threonine protein kinase
WM2015_280	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WM2015_2800	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
WM2015_2807	COG0640	Transcriptional regulator
WM2015_2808	COG0739	heme binding
WM2015_2809	COG1760	l-serine dehydratase
WM2015_281	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WM2015_2811	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WM2015_2815	COG1461	Dihydroxyacetone kinase
WM2015_2816	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WM2015_2817	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WM2015_2817	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WM2015_2818	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
WM2015_282	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WM2015_2820	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WM2015_2821	COG1040	competence protein
WM2015_2822	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WM2015_2823	COG0156	8-amino-7-oxononanoate synthase activity
WM2015_2827	COG3706	GGDEF domain
WM2015_2827	COG0745	RESPONSE REGULATOR receiver
WM2015_283	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WM2015_2830	COG4681	YaeQ
WM2015_2836	COG3706	GGDEF domain
WM2015_2837	COG4221	oxidoreductase activity
WM2015_2839	COG0415	Belongs to the DNA photolyase family
WM2015_2842	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
WM2015_285	COG0358	DNA primase activity
WM2015_286	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WM2015_2864	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WM2015_2867	COG3668	Plasmid stabilization system
WM2015_2868	COG3609	addiction module antidote protein, CC2985 family
WM2015_2869	COG2226	methyltransferase
WM2015_2876	COG0750	zinc metalloprotease
WM2015_2881	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WM2015_2883	COG0330	HflC and HflK could
WM2015_2887	COG1741	Belongs to the pirin family
WM2015_2888	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WM2015_2889	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WM2015_2891	COG3268	Saccharopine dehydrogenase
WM2015_2892	COG0418	dihydroorotase activity
WM2015_2895	COG1597	lipid kinase activity
WM2015_2898	COG1666	GTP binding
WM2015_2899	COG0204	Acyl-transferase
WM2015_2900	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WM2015_2901	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_2903	COG1960	acyl-CoA dehydrogenase activity
WM2015_2909	COG0393	Putative heavy-metal-binding
WM2015_291	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WM2015_2913	COG0277	FAD linked oxidase domain protein
WM2015_292	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WM2015_2921	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WM2015_2925	COG1643	Atp-dependent helicase
WM2015_2926	COG1643	Atp-dependent helicase
WM2015_293	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WM2015_2934	COG2354	Protein conserved in bacteria
WM2015_2935	COG0346	lactoylglutathione lyase activity
WM2015_2937	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
WM2015_2943	COG0297	glycogen (starch) synthase activity
WM2015_2958	COG1166	arginine decarboxylase activity
WM2015_2959	COG2084	Dehydrogenase
WM2015_2963	COG1115	amino acid carrier protein
WM2015_2968	COG0018	arginyl-trna synthetase
WM2015_2969	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WM2015_297	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WM2015_2970	COG0656	L-ascorbic acid biosynthetic process
WM2015_2972	COG1404	Belongs to the peptidase S8 family
WM2015_2973	COG1404	Belongs to the peptidase S8 family
WM2015_2976	COG0842	Transport permease protein
WM2015_2977	COG1131	(ABC) transporter
WM2015_2979	COG4555	ABC transporter
WM2015_2980	COG1668	transmembrane transport
WM2015_2982	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WM2015_2990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WM2015_2991	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WM2015_2992	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WM2015_2992	COG0131	Imidazoleglycerol-phosphate dehydratase
WM2015_2994	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WM2015_2997	COG2200	EAL domain
WM2015_2997	COG2199	diguanylate cyclase activity
WM2015_3	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WM2015_30	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WM2015_300	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WM2015_3000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WM2015_3003	COG0579	oxidoreductase
WM2015_3009	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WM2015_3014	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_3015	COG2311	Membrane
WM2015_302	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WM2015_3029	COG1794	racemase activity, acting on amino acids and derivatives
WM2015_303	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WM2015_3030	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
WM2015_3034	COG4585	Histidine kinase
WM2015_3050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WM2015_3052	COG1773	rubredoxin
WM2015_3053	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
WM2015_3055	COG0210	DNA helicase
WM2015_3058	COG4251	negative regulation of phosphorylation
WM2015_3058	COG3706	GGDEF domain
WM2015_3058	COG5001	Diguanylate cyclase
WM2015_3058	COG2203	Gaf domain
WM2015_3059	COG0583	DNA-binding transcription factor activity
WM2015_3062	COG0435	Glutathione S-transferase
WM2015_3064	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WM2015_3065	COG0706	membrane insertase activity
WM2015_3066	COG0594	ribonuclease P activity
WM2015_3067	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WM2015_31	COG0004	ammonium transporteR
WM2015_312	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WM2015_312	COG1754	DNA topoisomerase type I activity
WM2015_313	COG2922	Belongs to the Smg family
WM2015_314	COG0758	DNA mediated transformation
WM2015_316	COG0242	peptide deformylase activity
WM2015_320	COG5000	phosphorelay sensor kinase activity
WM2015_321	COG2204	response regulator
WM2015_322	COG0569	domain protein
WM2015_323	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WM2015_324	COG0009	L-threonylcarbamoyladenylate synthase
WM2015_327	COG0116	Belongs to the methyltransferase superfamily
WM2015_327	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WM2015_330	COG1136	(ABC) transporter
WM2015_331	COG4591	ABC-type transport system involved in lipoprotein release permease component
WM2015_334	COG3273	potassium ion transport
WM2015_334	COG0471	metal ion transport
WM2015_335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WM2015_336	COG3273	potassium ion transport
WM2015_336	COG0471	metal ion transport
WM2015_337	COG1331	Highly conserved protein containing a thioredoxin domain
WM2015_338	COG3706	GGDEF domain
WM2015_341	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WM2015_343	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WM2015_347	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WM2015_347	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WM2015_350	COG0509	glycine decarboxylation via glycine cleavage system
WM2015_351	COG1515	deoxyribonuclease V activity
WM2015_354	COG0459	protein refolding
WM2015_355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WM2015_357	COG4232	protein-disulfide reductase activity
WM2015_358	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WM2015_359	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WM2015_36	COG0433	COG0433 Predicted ATPase
WM2015_360	COG0511	ligase activity, forming carbon-carbon bonds
WM2015_361	COG0439	Biotin carboxylase
WM2015_364	COG0840	transmembrane signaling receptor activity
WM2015_367	COG0189	ligase activity
WM2015_368	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
WM2015_369	COG1678	Uncharacterized ACR, COG1678
WM2015_370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WM2015_371	COG0540	Belongs to the ATCase OTCase family
WM2015_373	COG0471	metal ion transport
WM2015_373	COG3273	potassium ion transport
WM2015_377	COG0651	ATP synthesis coupled electron transport
WM2015_379	COG0651	ATP synthesis coupled electron transport
WM2015_380	COG0651	ATP synthesis coupled electron transport
WM2015_381	COG1006	Multisubunit Na H antiporter MnhC subunit
WM2015_384	COG1320	monovalent cation:proton antiporter activity
WM2015_387	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WM2015_388	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WM2015_39	COG1278	Cold shock
WM2015_390	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
WM2015_392	COG1446	asparaginase
WM2015_394	COG0494	nUDIX hydrolase
WM2015_396	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WM2015_396	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WM2015_398	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WM2015_399	COG0531	amino acid
WM2015_4	COG0187	DNA topoisomerase II activity
WM2015_402	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WM2015_404	COG0142	geranyltranstransferase activity
WM2015_406	COG0564	pseudouridine synthase activity
WM2015_408	COG0069	glutamate synthase activity
WM2015_41	COG0076	glutamate decarboxylase activity
WM2015_410	COG0504	CTP synthase activity
WM2015_411	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WM2015_412	COG0148	phosphopyruvate hydratase activity
WM2015_417	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WM2015_418	COG0252	asparaginase activity
WM2015_422	COG1393	Belongs to the ArsC family
WM2015_423	COG1959	2 iron, 2 sulfur cluster binding
WM2015_423	COG1295	ribonuclease BN
WM2015_424	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WM2015_425	COG1254	Belongs to the acylphosphatase family
WM2015_428	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WM2015_430	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WM2015_431	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WM2015_432	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WM2015_434	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WM2015_435	COG0750	zinc metalloprotease
WM2015_436	COG0575	Belongs to the CDS family
WM2015_437	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WM2015_438	COG0233	cytoplasmic translational termination
WM2015_439	COG0528	UMP kinase activity
WM2015_440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WM2015_441	COG0052	Belongs to the universal ribosomal protein uS2 family
WM2015_443	COG3264	Mechanosensitive ion channel
WM2015_443	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WM2015_444	COG0442	prolyl-tRNA aminoacylation
WM2015_446	COG1183	phosphatidylcholine synthase activity
WM2015_467	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WM2015_472	COG0811	peptide transport
WM2015_473	COG0811	peptide transport
WM2015_474	COG0848	biopolymer transport protein
WM2015_478	COG4974	Belongs to the 'phage' integrase family
WM2015_479	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WM2015_482	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WM2015_483	COG1459	type II secretion system
WM2015_484	COG2165	general secretion pathway protein
WM2015_485	COG4970	Tfp pilus assembly protein FimT
WM2015_486	COG2165	general secretion pathway protein
WM2015_488	COG3156	type II secretion system protein K
WM2015_492	COG1450	Type ii and iii secretion system protein
WM2015_496	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WM2015_504	COG0488	(ABC) transporter
WM2015_505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WM2015_506	COG0515	serine threonine protein kinase
WM2015_508	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WM2015_511	COG0217	transcriptional regulatory protein
WM2015_512	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WM2015_513	COG0632	four-way junction helicase activity
WM2015_515	COG0824	Thioesterase
WM2015_52	COG0842	Transport permease protein
WM2015_520	COG2885	chlorophyll binding
WM2015_522	COG0602	queuosine metabolic process
WM2015_523	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WM2015_525	COG0175	sulfate reduction
WM2015_528	COG0612	Peptidase, M16
WM2015_529	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WM2015_53	COG1131	(ABC) transporter
WM2015_530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WM2015_532	COG1067	ATP-dependent peptidase activity
WM2015_534	COG0527	aspartate kinase activity
WM2015_537	COG0515	serine threonine protein kinase
WM2015_537	COG2815	serine threonine protein kinase
WM2015_538	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WM2015_539	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
WM2015_542	COG0488	(ABC) transporter
WM2015_544	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
WM2015_545	COG1278	Cold shock
WM2015_548	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
WM2015_549	COG0671	phosphoesterase, PA-phosphatase related
WM2015_550	COG0720	synthase
WM2015_552	COG2226	methyltransferase
WM2015_554	COG2264	protein methyltransferase activity
WM2015_555	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WM2015_565	COG0483	inositol monophosphate 1-phosphatase activity
WM2015_566	COG0494	nUDIX hydrolase
WM2015_569	COG0316	Belongs to the HesB IscA family
WM2015_570	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
WM2015_574	COG1136	(ABC) transporter
WM2015_576	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
WM2015_577	COG0166	Belongs to the GPI family
WM2015_579	COG3220	belongs to the UPF0276 family
WM2015_581	COG2259	Doxx family
WM2015_582	COG0495	leucyl-tRNA aminoacylation
WM2015_585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WM2015_588	COG0424	maF-like protein
WM2015_589	COG1530	ribonuclease E activity
WM2015_591	COG0312	modulator of DNA gyrase
WM2015_592	COG0312	modulator of DNA gyrase
WM2015_595	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_597	COG0149	triose-phosphate isomerase activity
WM2015_599	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WM2015_6	COG0751	glycine-tRNA ligase activity
WM2015_600	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WM2015_601	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WM2015_602	COG0649	NAD binding
WM2015_604	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WM2015_606	COG1034	ATP synthesis coupled electron transport
WM2015_607	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WM2015_608	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WM2015_610	COG0713	ATP synthesis coupled electron transport
WM2015_614	COG1007	ATP synthesis coupled electron transport
WM2015_615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WM2015_616	COG1214	PFAM Peptidase M22, glycoprotease
WM2015_622	COG1199	ATP-dependent helicase activity
WM2015_624	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WM2015_625	COG1216	Glycosyl transferase, family 2
WM2015_625	COG0438	transferase activity, transferring glycosyl groups
WM2015_628	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WM2015_63	COG2304	oxidoreductase activity
WM2015_634	COG1643	Atp-dependent helicase
WM2015_636	COG1137	ATPase activity
WM2015_639	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WM2015_643	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WM2015_644	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WM2015_645	COG1538	Outer membrane efflux protein
WM2015_646	COG1519	Transferase
WM2015_647	COG1560	Kdo2-lipid A biosynthetic process
WM2015_648	COG0463	Glycosyl transferase, family 2
WM2015_650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WM2015_651	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WM2015_655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WM2015_657	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WM2015_657	COG0543	2 iron, 2 sulfur cluster binding
WM2015_662	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
WM2015_663	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
WM2015_664	COG3639	organic phosphonate transmembrane transporter activity
WM2015_665	COG3639	organic phosphonate transmembrane transporter activity
WM2015_669	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WM2015_674	COG4585	Histidine kinase
WM2015_675	COG2197	response regulator
WM2015_676	COG2234	aminopeptidase activity
WM2015_682	COG0024	Methionine aminopeptidase
WM2015_683	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WM2015_684	COG2171	N-acyltransferase activity
WM2015_685	COG1393	Belongs to the ArsC family
WM2015_686	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WM2015_691	COG0457	Tetratricopeptide repeat
WM2015_696	COG2081	HI0933 family
WM2015_699	COG0515	serine threonine protein kinase
WM2015_699	COG2815	serine threonine protein kinase
WM2015_708	COG0339	signal peptide processing
WM2015_71	COG1228	amidohydrolase
WM2015_719	COG1301	dicarboxylic acid transport
WM2015_723	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WM2015_726	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WM2015_728	COG2326	polyphosphate kinase activity
WM2015_739	COG1404	Belongs to the peptidase S8 family
WM2015_74	COG1404	Belongs to the peptidase S8 family
WM2015_744	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WM2015_745	COG0438	transferase activity, transferring glycosyl groups
WM2015_749	COG2031	fatty acid transporter
WM2015_750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WM2015_751	COG1162	GTPase activity
WM2015_755	COG2267	carboxylic ester hydrolase activity
WM2015_757	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WM2015_758	COG1959	2 iron, 2 sulfur cluster binding
WM2015_763	COG3384	dioxygenase
WM2015_764	COG2259	Doxx family
WM2015_765	COG0583	DNA-binding transcription factor activity
WM2015_768	COG1247	-acetyltransferase
WM2015_780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WM2015_782	COG0435	Glutathione S-transferase
WM2015_785	COG2815	serine threonine protein kinase
WM2015_785	COG0515	serine threonine protein kinase
WM2015_795	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
WM2015_799	COG1598	PFAM Uncharacterised protein family UPF0150
WM2015_8	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WM2015_8	COG0519	Catalyzes the synthesis of GMP from XMP
WM2015_807	COG3655	Transcriptional regulator
WM2015_811	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WM2015_819	COG2311	Membrane
WM2015_82	COG3275	phosphorelay sensor kinase activity
WM2015_823	COG0288	reversible hydration of carbon dioxide
WM2015_824	COG3710	Transcriptional regulator
WM2015_824	COG0457	Tetratricopeptide repeat
WM2015_839	COG4771	TonB-dependent receptor
WM2015_84	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WM2015_843	COG2815	serine threonine protein kinase
WM2015_843	COG0515	serine threonine protein kinase
WM2015_844	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WM2015_845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM2015_847	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WM2015_848	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WM2015_849	COG0123	including yeast histone deacetylase and acetoin utilization protein
WM2015_85	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
WM2015_850	COG2096	Adenosyltransferase
WM2015_859	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WM2015_864	COG0463	Glycosyl transferase, family 2
WM2015_864	COG0457	Tetratricopeptide repeat
WM2015_866	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WM2015_867	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM2015_869	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WM2015_873	COG2311	Membrane
WM2015_884	COG1113	amino acid transport
WM2015_887	COG1063	alcohol dehydrogenase
WM2015_90	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WM2015_901	COG1012	belongs to the aldehyde dehydrogenase family
WM2015_902	COG0471	metal ion transport
WM2015_903	COG0542	response to heat
WM2015_910	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WM2015_911	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WM2015_912	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WM2015_914	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WM2015_915	COG0617	tRNA 3'-terminal CCA addition
WM2015_917	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WM2015_918	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WM2015_919	COG1192	Involved in chromosome partitioning
WM2015_925	COG3273	potassium ion transport
WM2015_925	COG0471	metal ion transport
WM2015_928	COG3028	Belongs to the UPF0307 family
WM2015_93	COG4946	Tricorn protease homolog
WM2015_93	COG0793	Belongs to the peptidase S41A family
WM2015_935	COG2321	neutral zinc metallopeptidase
WM2015_937	COG0347	Belongs to the P(II) protein family
WM2015_939	COG1131	(ABC) transporter
WM2015_941	COG1228	amidohydrolase
WM2015_942	COG4585	Histidine kinase
WM2015_943	COG2197	response regulator
WM2015_946	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
WM2015_947	COG5001	Diguanylate cyclase
WM2015_947	COG4251	negative regulation of phosphorylation
WM2015_947	COG3706	GGDEF domain
WM2015_947	COG2203	Gaf domain
WM2015_949	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WM2015_95	COG1136	(ABC) transporter
WM2015_95	COG0577	efflux transmembrane transporter activity
WM2015_950	COG5380	lipid catabolic process
WM2015_951	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
WM2015_953	COG2815	serine threonine protein kinase
WM2015_953	COG0515	serine threonine protein kinase
WM2015_96	COG1136	(ABC) transporter
WM2015_960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WM2015_961	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WM2015_963	COG0436	Aminotransferase
WM2015_964	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WM2015_966	COG1042	CoA-binding domain protein
WM2015_966	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WM2015_966	COG0045	succinate-CoA ligase (ADP-forming) activity
WM2015_967	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WM2015_968	COG1968	undecaprenyl-diphosphatase activity
WM2015_969	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
WM2015_97	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM2015_971	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
WM2015_972	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_978	COG2153	protein acetylation
WM2015_984	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_986	COG3094	Invasion gene expression up-regulator, SirB
WM2015_987	COG0427	acetyl-CoA hydrolase