locus-tag	class	description
IC757_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IC757_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IC757_00020	COG0187	DNA topoisomerase II activity
IC757_00030	COG0751	glycine-tRNA ligase activity
IC757_00040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IC757_00040	COG0519	Catalyzes the synthesis of GMP from XMP
IC757_00045	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IC757_00050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IC757_00065	COG0733	neurotransmitter:sodium symporter activity
IC757_00095	COG0823	Involved in the tonB-independent uptake of proteins
IC757_00095	COG1506	peptidase
IC757_00100	COG2954	triphosphatase activity
IC757_00115	COG0626	cystathionine gamma-synthase activity
IC757_00120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IC757_00125	COG4232	protein-disulfide reductase activity
IC757_00135	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IC757_00140	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IC757_00165	COG3710	Transcriptional regulator
IC757_00175	COG1278	Cold shock
IC757_00190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IC757_00235	COG2226	methyltransferase
IC757_00265	COG1752	Esterase of the alpha-beta hydrolase superfamily
IC757_00270	COG0693	protein deglycase activity
IC757_00280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IC757_00280	COG1648	precorrin-2 dehydrogenase activity
IC757_00285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IC757_00290	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IC757_00295	COG0175	sulfate reduction
IC757_00305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IC757_00310	COG0626	cystathionine gamma-synthase activity
IC757_00340	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IC757_00345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IC757_00355	COG2003	Belongs to the UPF0758 family
IC757_00360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IC757_00375	COG1187	pseudouridine synthase activity
IC757_00390	COG0601	transmembrane transport
IC757_00395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IC757_00400	COG0444	Belongs to the ABC transporter superfamily
IC757_00405	COG4608	Belongs to the ABC transporter superfamily
IC757_00410	COG0357	Ribosomal RNA small subunit methyltransferase G
IC757_00415	COG1192	Involved in chromosome partitioning
IC757_00420	COG1475	DNA binding
IC757_00430	COG0356	it plays a direct role in the translocation of protons across the membrane
IC757_00445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IC757_00450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IC757_00455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IC757_00460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IC757_00465	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IC757_00480	COG0037	tRNA processing
IC757_00490	COG2937	Belongs to the GPAT DAPAT family
IC757_00495	COG0284	orotidine-5'-phosphate decarboxylase activity
IC757_00500	COG0596	Alpha beta hydrolase
IC757_00505	COG0210	DNA helicase
IC757_00510	COG0151	Belongs to the GarS family
IC757_00515	COG0138	bifunctional purine biosynthesis protein purh
IC757_00540	COG1136	(ABC) transporter
IC757_00545	COG0577	efflux transmembrane transporter activity
IC757_00555	COG0708	Exodeoxyribonuclease III
IC757_00560	COG2807	transmembrane transport
IC757_00575	COG0739	heme binding
IC757_00580	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IC757_00595	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IC757_00600	COG0137	argininosuccinate synthase activity
IC757_00605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IC757_00610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IC757_00620	COG0165	Argininosuccinate lyase
IC757_00650	COG4067	protein conserved in archaea
IC757_00650	COG0189	ligase activity
IC757_00665	COG1301	dicarboxylic acid transport
IC757_00670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IC757_00680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IC757_00685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IC757_00690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IC757_00695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IC757_00700	COG0301	tRNA thio-modification
IC757_00700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IC757_00715	COG3795	YCII-related domain
IC757_00725	COG4941	Belongs to the sigma-70 factor family
IC757_00730	COG3795	YCII-related domain
IC757_00770	COG2234	aminopeptidase activity
IC757_00790	COG3549	Plasmid maintenance system killer
IC757_00805	COG0604	alcohol dehydrogenase
IC757_00805	COG3321	synthase
IC757_00815	COG4115	mRNA cleavage
IC757_00820	COG2161	toxin-antitoxin pair type II binding
IC757_00855	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IC757_00900	COG3177	Filamentation induced by cAMP protein fic
IC757_00905	COG1061	Type III restriction enzyme res subunit
IC757_00915	COG3457	Alanine racemase
IC757_00935	COG3275	phosphorelay sensor kinase activity
IC757_00940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IC757_00945	COG1283	sodium-dependent phosphate transmembrane transporter activity
IC757_00950	COG0704	Plays a role in the regulation of phosphate uptake
IC757_00960	COG4636	protein conserved in cyanobacteria
IC757_00965	COG4942	peptidase
IC757_00980	COG1487	ribonuclease activity
IC757_01080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IC757_01085	COG1077	Cell shape determining protein MreB Mrl
IC757_01090	COG1792	Involved in formation and maintenance of cell shape
IC757_01095	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IC757_01100	COG0768	penicillin binding
IC757_01105	COG0772	Belongs to the SEDS family
IC757_01110	COG2951	lytic endotransglycosylase activity
IC757_01115	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IC757_01120	COG1686	Belongs to the peptidase S11 family
IC757_01130	COG0321	lipoyl(octanoyl) transferase activity
IC757_01135	COG0793	Belongs to the peptidase S41A family
IC757_01140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IC757_01145	COG4953	penicillin-binding protein 1C
IC757_01160	COG0405	Gamma-glutamyltransferase
IC757_01165	COG0254	rRNA binding
IC757_01180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IC757_01185	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IC757_01190	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IC757_01195	COG1561	YicC-like family, N-terminal region
IC757_01205	COG1758	RNA polymerase activity
IC757_01210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IC757_01225	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IC757_01240	COG0372	Belongs to the citrate synthase family
IC757_01245	COG1028	Short-chain dehydrogenase reductase Sdr
IC757_01250	COG0586	Pfam SNARE associated Golgi protein
IC757_01260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IC757_01280	COG0205	6-phosphofructokinase activity
IC757_01285	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IC757_01290	COG4206	TonB-dependent receptor
IC757_01300	COG4372	Transposase
IC757_01325	COG0811	peptide transport
IC757_01330	COG0848	biopolymer transport protein
IC757_01335	COG0848	biopolymer transport protein
IC757_01355	COG4999	Histidine kinase
IC757_01355	COG3850	Histidine kinase
IC757_01355	COG3437	response regulator, receiver
IC757_01355	COG2205	protein histidine kinase activity
IC757_01360	COG1704	LemA family
IC757_01365	COG0501	Belongs to the peptidase M48B family
IC757_01380	COG1028	Short-chain dehydrogenase reductase Sdr
IC757_01390	COG0302	gtp cyclohydrolase
IC757_01390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IC757_01400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IC757_01415	COG0358	DNA primase activity
IC757_01435	COG5001	Diguanylate cyclase
IC757_01435	COG3300	MHYT domain
IC757_01445	COG2885	chlorophyll binding
IC757_01455	COG0154	amidase activity
IC757_01460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IC757_01465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IC757_01470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IC757_01475	COG5285	phytanoyl-CoA dioxygenase
IC757_01485	COG3064	Membrane
IC757_01495	COG1272	protein, Hemolysin III
IC757_01500	COG0745	RESPONSE REGULATOR receiver
IC757_01510	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IC757_01515	COG2894	cell division
IC757_01530	COG1473	amidohydrolase
IC757_01535	COG3360	Dodecin
IC757_01540	COG0488	(ABC) transporter
IC757_01560	COG3483	tryptophan 2,3-dioxygenase activity
IC757_01565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC757_01570	COG3844	kynureninase activity
IC757_01585	COG0662	Cupin 2, conserved barrel domain protein
IC757_01615	COG2986	histidine ammonia-lyase
IC757_01630	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IC757_01690	COG2226	methyltransferase
IC757_01695	COG1040	competence protein
IC757_01715	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IC757_01725	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IC757_01730	COG1461	Dihydroxyacetone kinase
IC757_01740	COG1760	l-serine dehydratase
IC757_01745	COG0739	heme binding
IC757_01795	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IC757_01800	COG1121	(ABC) transporter
IC757_01815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IC757_01830	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IC757_01835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IC757_01840	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IC757_01845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IC757_01855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IC757_01855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IC757_01890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IC757_01905	COG0084	hydrolase, TatD family'
IC757_01910	COG1959	2 iron, 2 sulfur cluster binding
IC757_01920	COG2832	Protein of unknown function (DUF454)
IC757_01930	COG3961	Belongs to the TPP enzyme family
IC757_01935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IC757_01935	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IC757_01945	COG0509	glycine decarboxylation via glycine cleavage system
IC757_01950	COG1515	deoxyribonuclease V activity
IC757_01960	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IC757_01975	COG0459	protein refolding
IC757_01980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IC757_01990	COG4232	protein-disulfide reductase activity
IC757_01995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IC757_02005	COG0511	ligase activity, forming carbon-carbon bonds
IC757_02010	COG0439	Biotin carboxylase
IC757_02020	COG0784	Response regulator, receiver
IC757_02020	COG0643	Histidine kinase
IC757_02020	COG2198	Histidine kinase
IC757_02025	COG0840	transmembrane signaling receptor activity
IC757_02040	COG0189	ligase activity
IC757_02045	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IC757_02050	COG1678	Uncharacterized ACR, COG1678
IC757_02055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IC757_02070	COG2022	thiamine diphosphate biosynthetic process
IC757_02075	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IC757_02080	COG0142	geranyltranstransferase activity
IC757_02090	COG0564	pseudouridine synthase activity
IC757_02100	COG0504	CTP synthase activity
IC757_02105	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IC757_02110	COG0148	phosphopyruvate hydratase activity
IC757_02115	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IC757_02140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IC757_02145	COG0252	asparaginase activity
IC757_02165	COG1393	Belongs to the ArsC family
IC757_02170	COG1959	2 iron, 2 sulfur cluster binding
IC757_02170	COG1295	ribonuclease BN
IC757_02175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IC757_02180	COG1254	Belongs to the acylphosphatase family
IC757_02185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IC757_02195	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IC757_02200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IC757_02220	COG0750	zinc metalloprotease
IC757_02225	COG0575	Belongs to the CDS family
IC757_02230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IC757_02235	COG0233	cytoplasmic translational termination
IC757_02240	COG0528	UMP kinase activity
IC757_02245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IC757_02250	COG0052	Belongs to the universal ribosomal protein uS2 family
IC757_02255	COG3264	Mechanosensitive ion channel
IC757_02255	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IC757_02265	COG1231	oxidoreductase activity
IC757_02280	COG0442	prolyl-tRNA aminoacylation
IC757_02285	COG1183	phosphatidylcholine synthase activity
IC757_02305	COG0823	Involved in the tonB-independent uptake of proteins
IC757_02305	COG1506	peptidase
IC757_02305	COG4946	Tricorn protease homolog
IC757_02315	COG4191	Histidine kinase
IC757_02315	COG0784	Response regulator, receiver
IC757_02320	COG0366	Alpha amylase catalytic
IC757_02340	COG1501	Belongs to the glycosyl hydrolase 31 family
IC757_02350	COG3550	peptidyl-serine autophosphorylation
IC757_02360	COG1874	Beta-galactosidase
IC757_02360	COG0366	Alpha amylase catalytic
IC757_02370	COG0800	Aldolase
IC757_02375	COG0837	glucose binding
IC757_02385	COG0363	glucosamine-6-phosphate deaminase activity
IC757_02390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IC757_02400	COG3706	GGDEF domain
IC757_02400	COG2203	Gaf domain
IC757_02400	COG4251	negative regulation of phosphorylation
IC757_02400	COG5001	Diguanylate cyclase
IC757_02415	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IC757_02420	COG0795	lipopolysaccharide-transporting ATPase activity
IC757_02445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IC757_02450	COG0047	phosphoribosylformylglycinamidine synthase activity
IC757_02450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IC757_02460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IC757_02465	COG1459	type II secretion system
IC757_02470	COG2165	general secretion pathway protein
IC757_02490	COG3156	type II secretion system protein K
IC757_02510	COG1450	Type ii and iii secretion system protein
IC757_02530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IC757_02555	COG0463	Glycosyl transferase, family 2
IC757_02565	COG0667	Aldo Keto reductase
IC757_02570	COG0488	(ABC) transporter
IC757_02575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IC757_02580	COG2119	membrane
IC757_02595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IC757_02610	COG0217	transcriptional regulatory protein
IC757_02615	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IC757_02620	COG0632	four-way junction helicase activity
IC757_02625	COG2255	four-way junction helicase activity
IC757_02630	COG0824	Thioesterase
IC757_02650	COG0823	Involved in the tonB-independent uptake of proteins
IC757_02655	COG2885	chlorophyll binding
IC757_02665	COG0602	queuosine metabolic process
IC757_02670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IC757_02685	COG0612	Peptidase, M16
IC757_02690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IC757_02695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IC757_02720	COG5001	Diguanylate cyclase
IC757_02770	COG0135	phosphoribosylanthranilate isomerase activity
IC757_02770	COG0134	indole-3-glycerol-phosphate synthase activity
IC757_02840	COG1067	ATP-dependent peptidase activity
IC757_02855	COG0527	aspartate kinase activity
IC757_02875	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IC757_02890	COG0488	(ABC) transporter
IC757_02905	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IC757_02910	COG0720	synthase
IC757_02950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IC757_02995	COG0483	inositol monophosphate 1-phosphatase activity
IC757_03000	COG0494	nUDIX hydrolase
IC757_03005	COG1981	membrane
IC757_03015	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IC757_03020	COG1228	amidohydrolase
IC757_03030	COG0577	efflux transmembrane transporter activity
IC757_03035	COG1136	(ABC) transporter
IC757_03045	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IC757_03050	COG0166	Belongs to the GPI family
IC757_03055	COG4946	Tricorn protease homolog
IC757_03055	COG1506	peptidase
IC757_03055	COG0823	Involved in the tonB-independent uptake of proteins
IC757_03060	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IC757_03065	COG1131	(ABC) transporter
IC757_03070	COG0842	Transport permease protein
IC757_03080	COG2095	MarC family integral membrane protein
IC757_03155	COG2828	Protein conserved in bacteria
IC757_03200	COG0405	Gamma-glutamyltransferase
IC757_03240	COG0009	L-threonylcarbamoyladenylate synthase
IC757_03245	COG0418	dihydroorotase activity
IC757_03275	COG1611	Belongs to the LOG family
IC757_03290	COG0275	rRNA processing
IC757_03295	COG3116	cell division
IC757_03305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IC757_03310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IC757_03315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IC757_03320	COG0772	Belongs to the SEDS family
IC757_03325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IC757_03330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IC757_03335	COG1181	Belongs to the D-alanine--D-alanine ligase family
IC757_03355	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IC757_03365	COG0653	protein targeting
IC757_03370	COG0494	nUDIX hydrolase
IC757_03380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IC757_03395	COG2226	methyltransferase
IC757_03405	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IC757_03420	COG2610	gluconate transmembrane transporter activity
IC757_03455	COG0596	Alpha beta hydrolase
IC757_03470	COG4152	abc transporter atp-binding protein
IC757_03480	COG2197	response regulator
IC757_03485	COG4585	Histidine kinase
IC757_03515	COG1131	(ABC) transporter
IC757_03550	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
IC757_03590	COG1595	DNA-templated transcription, initiation
IC757_03650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC757_03650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IC757_03690	COG1487	ribonuclease activity
IC757_03740	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IC757_03745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IC757_03760	COG0617	tRNA 3'-terminal CCA addition
IC757_03765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IC757_03770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IC757_03775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IC757_03780	COG1192	Involved in chromosome partitioning
IC757_03815	COG0339	signal peptide processing
IC757_03820	COG0436	Aminotransferase
IC757_03840	COG4657	Part of a membrane complex involved in electron transport
IC757_03845	COG4660	Part of a membrane complex involved in electron transport
IC757_03855	COG4658	electron transport chain
IC757_03860	COG4656	Part of a membrane complex involved in electron transport
IC757_03865	COG1013	pyruvate-flavodoxin oxidoreductase activity
IC757_03865	COG0674	pyruvate-flavodoxin oxidoreductase activity
IC757_03865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IC757_03865	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IC757_03870	COG2878	Part of a membrane complex involved in electron transport
IC757_03880	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IC757_03895	COG3038	cytochrome b561
IC757_03900	COG2353	YceI-like domain
IC757_03920	COG0492	ferredoxin-NADP+ reductase activity
IC757_03925	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IC757_03935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC757_03940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IC757_03945	COG0006	proline dipeptidase activity
IC757_03980	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IC757_03985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IC757_03995	COG1834	amidinotransferase
IC757_04015	COG3956	TIGRFAM MazG family protein
IC757_04025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IC757_04025	COG1181	Belongs to the D-alanine--D-alanine ligase family
IC757_04040	COG4106	trans-aconitate 2-methyltransferase activity
IC757_04050	COG2205	protein histidine kinase activity
IC757_04050	COG2198	Histidine kinase
IC757_04050	COG0784	Response regulator, receiver
IC757_04060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IC757_04065	COG0596	Alpha beta hydrolase
IC757_04070	COG0318	PFAM AMP-dependent synthetase and ligase
IC757_04075	COG2079	MmgE PrpD family protein
IC757_04090	COG1473	amidohydrolase
IC757_04095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IC757_04100	COG0006	proline dipeptidase activity
IC757_04105	COG1012	belongs to the aldehyde dehydrogenase family
IC757_04130	COG1231	oxidoreductase activity
IC757_04140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IC757_04150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IC757_04155	COG0642	Histidine kinase
IC757_04175	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IC757_04180	COG0745	RESPONSE REGULATOR receiver
IC757_04190	COG3118	belongs to the thioredoxin family
IC757_04195	COG0513	Belongs to the DEAD box helicase family
IC757_04220	COG2884	Cell division ATP-binding protein ftsE
IC757_04225	COG2177	Part of the ABC transporter FtsEX involved in
IC757_04245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IC757_04270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IC757_04275	COG0081	regulation of translation
IC757_04280	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IC757_04285	COG0222	ribosome binding
IC757_04290	COG0085	RNA polymerase activity
IC757_04295	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IC757_04300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IC757_04305	COG0049	tRNA binding
IC757_04310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IC757_04315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IC757_04320	COG0051	transcription antitermination factor activity, RNA binding
IC757_04325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IC757_04330	COG0088	Forms part of the polypeptide exit tunnel
IC757_04335	COG0089	rRNA binding
IC757_04340	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IC757_04345	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IC757_04350	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IC757_04355	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IC757_04380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IC757_04385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IC757_04390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IC757_04395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IC757_04400	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IC757_04405	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IC757_04415	COG1841	ribosomal large subunit assembly
IC757_04420	COG0200	Binds to the 23S rRNA
IC757_04425	COG0201	protein transport
IC757_04430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IC757_04435	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IC757_04440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IC757_04445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IC757_04450	COG0202	RNA polymerase activity
IC757_04455	COG0203	ribosomal protein L17
IC757_04495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IC757_04505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IC757_04510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IC757_04510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IC757_04525	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IC757_04530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IC757_04535	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IC757_04540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IC757_04550	COG2823	Periplasmic or secreted lipoprotein
IC757_04555	COG0792	nuclease activity
IC757_04570	COG2738	Putative neutral zinc metallopeptidase
IC757_04590	COG0688	phosphatidylethanolamine metabolic process
IC757_04595	COG2890	protein-(glutamine-N5) methyltransferase activity
IC757_04600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IC757_04610	COG2086	electron transfer activity
IC757_04620	COG3706	GGDEF domain
IC757_04630	COG1201	RNA secondary structure unwinding
IC757_04710	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IC757_04725	COG5001	Diguanylate cyclase
IC757_04730	COG3706	GGDEF domain
IC757_04735	COG2610	gluconate transmembrane transporter activity
IC757_04740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IC757_04745	COG0083	homoserine kinase activity
IC757_04750	COG0460	homoserine dehydrogenase
IC757_04750	COG0527	aspartate kinase activity
IC757_04755	COG2855	membrane
IC757_04760	COG1505	serine-type exopeptidase activity
IC757_04785	COG0616	signal peptide processing
IC757_04790	COG0673	inositol 2-dehydrogenase activity
IC757_04815	COG0662	Cupin 2, conserved barrel domain protein
IC757_04820	COG0800	Aldolase
IC757_04825	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IC757_04830	COG0167	dihydroorotate dehydrogenase activity
IC757_04835	COG1012	belongs to the aldehyde dehydrogenase family
IC757_04860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IC757_04865	COG0481	GTPase activity
IC757_04870	COG0681	Belongs to the peptidase S26 family
IC757_04880	COG0571	ribonuclease III activity
IC757_04885	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IC757_04890	COG1381	Involved in DNA repair and RecF pathway recombination
IC757_04895	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IC757_04910	COG4536	flavin adenine dinucleotide binding
IC757_04920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IC757_04925	COG0228	four-way junction DNA binding
IC757_04935	COG0336	Belongs to the RNA methyltransferase TrmD family
IC757_04975	COG2433	Pfam Transposase IS66
IC757_04980	COG4372	Transposase
IC757_05035	COG4372	Transposase
IC757_05060	COG4372	Transposase
IC757_05100	COG0406	alpha-ribazole phosphatase activity
IC757_05105	COG0335	large ribosomal subunit rRNA binding
IC757_05120	COG0326	Molecular chaperone. Has ATPase activity
IC757_05150	COG3706	GGDEF domain
IC757_05160	COG1047	Peptidyl-prolyl cis-trans
IC757_05165	COG1288	antiporter activity
IC757_05170	COG1960	acyl-CoA dehydrogenase activity
IC757_05195	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IC757_05230	COG1028	Short-chain dehydrogenase reductase Sdr
IC757_05245	COG0183	Belongs to the thiolase family
IC757_05250	COG0183	Belongs to the thiolase family
IC757_05255	COG1021	2,3-dihydroxybenzoate-AMP ligase
IC757_05260	COG2070	2-Nitropropane dioxygenase
IC757_05270	COG4771	TonB-dependent receptor
IC757_05275	COG0564	pseudouridine synthase activity
IC757_05290	COG2866	Carboxypeptidase
IC757_05300	COG1028	Short-chain dehydrogenase reductase Sdr
IC757_05310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IC757_05315	COG1295	ribonuclease BN
IC757_05325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IC757_05340	COG0517	IMP dehydrogenase activity
IC757_05340	COG1994	Peptidase M50
IC757_05355	COG4181	ATPase activity
IC757_05370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IC757_05385	COG0101	tRNA pseudouridine synthase activity
IC757_05390	COG0135	phosphoribosylanthranilate isomerase activity
IC757_05395	COG0133	tryptophan synthase activity
IC757_05400	COG0159	tryptophan synthase activity
IC757_05405	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IC757_05410	COG0285	dihydrofolate synthase activity
IC757_05420	COG1286	toxin biosynthetic process
IC757_05430	COG0415	Belongs to the DNA photolyase family
IC757_05445	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IC757_05450	COG4783	chaperone-mediated protein folding
IC757_05470	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IC757_05475	COG0473	3-isopropylmalate dehydrogenase activity
IC757_05480	COG0351	phosphomethylpyrimidine kinase
IC757_05505	COG0142	geranyltranstransferase activity
IC757_05545	COG1024	Enoyl-CoA hydratase
IC757_05565	COG1842	Phage shock protein A
IC757_05570	COG0545	Peptidyl-prolyl cis-trans isomerase
IC757_05610	COG1028	Short-chain dehydrogenase reductase Sdr
IC757_05620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IC757_05625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IC757_05630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IC757_05635	COG0268	Binds directly to 16S ribosomal RNA
IC757_05645	COG0003	Pfam Anion-transporting ATPase
IC757_05655	COG1966	Carbon starvation protein
IC757_05660	COG0196	riboflavin kinase activity
IC757_05665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IC757_05670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IC757_05680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IC757_05690	COG0193	aminoacyl-tRNA hydrolase activity
IC757_05695	COG0012	GTP binding
IC757_05720	COG0668	transmembrane transport
IC757_05730	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IC757_05745	COG2815	serine threonine protein kinase
IC757_05745	COG0515	serine threonine protein kinase
IC757_05755	COG1968	undecaprenyl-diphosphatase activity
IC757_05760	COG3385	transposase activity
IC757_05780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IC757_05795	COG0181	hydroxymethylbilane synthase activity
IC757_05840	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IC757_05850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IC757_05850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IC757_05880	COG0717	Belongs to the dCTP deaminase family
IC757_05885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IC757_05890	COG0723	plastoquinol--plastocyanin reductase activity
IC757_05895	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IC757_05900	COG2857	Cytochrome c1
IC757_05905	COG0625	glutathione transferase activity
IC757_05910	COG2969	positive regulation of protein catabolic process
IC757_05925	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IC757_05930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IC757_05950	COG1534	Rna-binding protein
IC757_05955	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IC757_05960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IC757_05965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IC757_05970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IC757_06015	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IC757_06020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IC757_06020	COG3153	acetyltransferase
IC757_06070	COG3311	Transcriptional regulator
IC757_06110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IC757_06130	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IC757_06135	COG3593	DNA synthesis involved in DNA repair
IC757_06140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IC757_06145	COG2867	negative regulation of translational initiation
IC757_06150	COG2914	Belongs to the UPF0125 (RnfH) family
IC757_06155	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IC757_06165	COG0497	DNA recombination
IC757_06170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IC757_06175	COG0443	Heat shock 70 kDa protein
IC757_06180	COG0484	heat shock protein binding
IC757_06185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IC757_06225	COG0463	Glycosyl transferase, family 2
IC757_06245	COG0651	ATP synthesis coupled electron transport
IC757_06250	COG0651	ATP synthesis coupled electron transport
IC757_06255	COG0651	ATP synthesis coupled electron transport
IC757_06270	COG1320	monovalent cation:proton antiporter activity
IC757_06280	COG1863	multisubunit Na H antiporter MnhE subunit
IC757_06315	COG0017	Asparaginyl-tRNA synthetase
IC757_06330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IC757_06330	COG0519	Catalyzes the synthesis of GMP from XMP
IC757_06335	COG0706	membrane insertase activity
IC757_06350	COG1368	sulfuric ester hydrolase activity
IC757_06355	COG0500	methyltransferase
IC757_06360	COG0590	tRNA wobble adenosine to inosine editing
IC757_06380	COG0339	signal peptide processing
IC757_06400	COG1215	transferase activity, transferring glycosyl groups
IC757_06415	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IC757_06580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IC757_06600	COG3385	transposase activity
IC757_06605	COG1216	Glycosyl transferase, family 2
IC757_06645	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IC757_06680	COG1216	Glycosyl transferase, family 2
IC757_06705	COG0529	Catalyzes the synthesis of activated sulfate
IC757_06705	COG2895	sulfate adenylyltransferase (ATP) activity
IC757_06710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IC757_06730	COG1960	acyl-CoA dehydrogenase activity
IC757_06735	COG2902	Dehydrogenase
IC757_06745	COG0402	S-adenosylhomocysteine deaminase activity
IC757_06755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IC757_06765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IC757_06780	COG3549	Plasmid maintenance system killer
IC757_06790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IC757_06820	COG2165	general secretion pathway protein
IC757_06840	COG1459	type II secretion system
IC757_06845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IC757_06855	COG3409	Peptidoglycan-binding domain 1 protein
IC757_06855	COG3267	Type II secretory pathway component ExeA
IC757_06915	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IC757_06920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IC757_06935	COG2925	Exonuclease
IC757_06940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IC757_06960	COG0741	lytic transglycosylase activity
IC757_06965	COG5002	protein histidine kinase activity
IC757_06970	COG0745	RESPONSE REGULATOR receiver
IC757_06980	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IC757_07000	COG1013	pyruvate-flavodoxin oxidoreductase activity
IC757_07005	COG0674	pyruvate-flavodoxin oxidoreductase activity
IC757_07005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IC757_07025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IC757_07030	COG2239	Acts as a magnesium transporter
IC757_07040	COG0360	Binds together with S18 to 16S ribosomal RNA
IC757_07060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IC757_07065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IC757_07070	COG1702	phosphate starvation-inducible protein PhoH
IC757_07075	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IC757_07080	COG4535	Mg2 and Co2 transporter CorC
IC757_07095	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IC757_07100	COG4988	ABC transporter
IC757_07105	COG1294	oxidase, subunit
IC757_07110	COG1271	oxidase subunit
IC757_07115	COG0432	Pfam Uncharacterised protein family UPF0047
IC757_07120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IC757_07125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IC757_07145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IC757_07150	COG1288	antiporter activity
IC757_07155	COG1960	acyl-CoA dehydrogenase activity
IC757_07170	COG0626	cystathionine gamma-synthase activity
IC757_07175	COG1522	sequence-specific DNA binding
IC757_07200	COG2915	High frequency lysogenization protein hflD homolog
IC757_07205	COG0482	sulfurtransferase activity
IC757_07215	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IC757_07220	COG2224	Isocitrate lyase
IC757_07225	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IC757_07230	COG0542	response to heat
IC757_07235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IC757_07260	COG0628	permease
IC757_07265	COG2235	arginine
IC757_07310	COG2815	serine threonine protein kinase
IC757_07310	COG0515	serine threonine protein kinase
IC757_07325	COG3093	addiction module antidote protein HigA
IC757_07375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC757_07390	COG0402	S-adenosylhomocysteine deaminase activity
IC757_07395	COG2133	pyrroloquinoline quinone binding
IC757_07435	COG0471	metal ion transport
IC757_07460	COG0515	serine threonine protein kinase
IC757_07460	COG2815	serine threonine protein kinase
IC757_07465	COG0501	Belongs to the peptidase M48B family
IC757_07475	COG2226	methyltransferase
IC757_07480	COG2217	Heavy metal translocating P-type atpase
IC757_07500	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC757_07520	COG2032	superoxide dismutase activity
IC757_07525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IC757_07530	COG0714	Associated with various cellular activities
IC757_07540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IC757_07545	COG0277	FAD linked oxidase domain protein
IC757_07550	COG1764	response to oxidative stress
IC757_07555	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IC757_07570	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IC757_07580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IC757_07585	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IC757_07590	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IC757_07595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IC757_07600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IC757_07605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IC757_07605	COG0072	phenylalanine-tRNA ligase activity
IC757_07610	COG0776	regulation of translation
IC757_07625	COG1469	GTP cyclohydrolase I activity
IC757_07635	COG0739	heme binding
IC757_07640	COG1388	LysM domain
IC757_07640	COG0741	lytic transglycosylase activity
IC757_07645	COG0557	exoribonuclease II activity
IC757_07650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IC757_07655	COG0590	tRNA wobble adenosine to inosine editing
IC757_07665	COG4191	Histidine kinase
IC757_07670	COG2204	response regulator
IC757_07675	COG2885	chlorophyll binding
IC757_07680	COG1187	pseudouridine synthase activity
IC757_07685	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IC757_07690	COG2350	Protein conserved in bacteria
IC757_07705	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IC757_07715	COG3115	cell septum assembly
IC757_07720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IC757_07735	COG0105	UTP biosynthetic process
IC757_07740	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IC757_07755	COG0124	histidyl-tRNA synthetase
IC757_07760	COG2976	Protein conserved in bacteria
IC757_07765	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IC757_07775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IC757_07785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IC757_07800	COG0183	Belongs to the thiolase family
IC757_07805	COG1250	3-hydroxyacyl-CoA dehydrogenase
IC757_07805	COG1024	Enoyl-CoA hydratase
IC757_07810	COG0424	maF-like protein
IC757_07815	COG1399	metal-binding, possibly nucleic acid-binding protein
IC757_07820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IC757_07825	COG0416	fatty acid biosynthetic process
IC757_07830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IC757_07835	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IC757_07850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IC757_07855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IC757_07860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IC757_07865	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IC757_07885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IC757_07890	COG0318	PFAM AMP-dependent synthetase and ligase
IC757_07910	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IC757_07920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IC757_07925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IC757_07940	COG3267	Type II secretory pathway component ExeA
IC757_07940	COG3409	Peptidoglycan-binding domain 1 protein
IC757_07965	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IC757_07975	COG4942	peptidase
IC757_07980	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IC757_07990	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IC757_07995	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IC757_08015	COG3459	Glycosyltransferase 36 associated
IC757_08020	COG0589	response to stress
IC757_08040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC757_08040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IC757_08075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IC757_08095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IC757_08120	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IC757_08140	COG4585	Histidine kinase
IC757_08145	COG2197	response regulator
IC757_08150	COG2329	Antibiotic biosynthesis monooxygenase
IC757_08155	COG0625	glutathione transferase activity
IC757_08195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IC757_08240	COG3267	Type II secretory pathway component ExeA
IC757_08240	COG3409	Peptidoglycan-binding domain 1 protein
IC757_08285	COG0732	type I restriction modification DNA specificity domain
IC757_08345	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IC757_08365	COG5001	Diguanylate cyclase
IC757_08385	COG4520	surface antigen
IC757_08395	COG5001	Diguanylate cyclase
IC757_08395	COG5002	protein histidine kinase activity
IC757_08410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IC757_08420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IC757_08425	COG0513	Belongs to the DEAD box helicase family
IC757_08435	COG3706	GGDEF domain
IC757_08465	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IC757_08475	COG1053	succinate dehydrogenase
IC757_08490	COG5508	conserved small protein
IC757_08495	COG0354	folic acid binding
IC757_08515	COG0322	excinuclease ABC activity
IC757_08520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IC757_08525	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IC757_08530	COG1663	tetraacyldisaccharide 4'-kinase activity
IC757_08535	COG1132	(ABC) transporter
IC757_08540	COG0848	biopolymer transport protein
IC757_08545	COG0811	peptide transport
IC757_08555	COG1136	(ABC) transporter
IC757_08560	COG4591	ABC-type transport system involved in lipoprotein release permease component
IC757_08565	COG0564	pseudouridine synthase activity
IC757_08570	COG1530	ribonuclease E activity
IC757_08580	COG2133	pyrroloquinoline quinone binding
IC757_08590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IC757_08605	COG4946	Tricorn protease homolog
IC757_08605	COG0823	Involved in the tonB-independent uptake of proteins
IC757_08605	COG1506	peptidase
IC757_08620	COG0537	adenosine 5'-monophosphoramidase activity
IC757_08645	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IC757_08650	COG0546	phosphoglycolate phosphatase activity
IC757_08655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IC757_08660	COG0402	S-adenosylhomocysteine deaminase activity
IC757_08665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IC757_08670	COG1509	lysine 2,3-aminomutase activity
IC757_08680	COG0501	Belongs to the peptidase M48B family
IC757_08685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IC757_08695	COG0037	tRNA processing
IC757_08710	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IC757_08715	COG1674	ftsk spoiiie
IC757_08720	COG0686	Belongs to the AlaDH PNT family
IC757_08725	COG0492	ferredoxin-NADP+ reductase activity
IC757_08735	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IC757_08755	COG0204	Acyl-transferase
IC757_08760	COG0071	Belongs to the small heat shock protein (HSP20) family
IC757_08765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IC757_08780	COG2815	serine threonine protein kinase
IC757_08780	COG0515	serine threonine protein kinase
IC757_08790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IC757_08795	COG2850	peptidyl-arginine hydroxylation
IC757_08800	COG0567	Dehydrogenase, E1 component
IC757_08815	COG0604	alcohol dehydrogenase
IC757_08825	COG0678	peroxiredoxin activity
IC757_08845	COG0109	protoheme IX farnesyltransferase activity
IC757_08850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IC757_08850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IC757_08865	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IC757_08870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IC757_08875	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IC757_08880	COG0492	ferredoxin-NADP+ reductase activity
IC757_08885	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IC757_08895	COG2201	protein-glutamate methylesterase activity
IC757_08900	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IC757_08905	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IC757_08910	COG0840	transmembrane signaling receptor activity
IC757_08920	COG0835	chemotaxis
IC757_08925	COG0840	transmembrane signaling receptor activity
IC757_08930	COG5002	protein histidine kinase activity
IC757_08930	COG5001	Diguanylate cyclase
IC757_08940	COG0835	chemotaxis
IC757_08950	COG1192	Involved in chromosome partitioning
IC757_08955	COG1360	Flagellar Motor Protein
IC757_08960	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IC757_08965	COG0784	Response regulator, receiver
IC757_08965	COG2198	Histidine kinase
IC757_08965	COG0643	Histidine kinase
IC757_08970	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IC757_09000	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IC757_09020	COG3190	flagellar
IC757_09060	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IC757_09070	COG1677	Flagellar hook-basal body complex protein FliE
IC757_09135	COG1943	Transposase
IC757_09140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IC757_09145	COG1256	bacterial-type flagellum assembly
IC757_09150	COG1705	Flagellar rod assembly protein muramidase FlgJ
IC757_09150	COG3951	Flagellar rod assembly protein muramidase FlgJ
IC757_09155	COG1706	bacterial-type flagellum-dependent cell motility
IC757_09160	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IC757_09170	COG4786	Flagellar basal body rod
IC757_09180	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IC757_09185	COG1558	bacterial-type flagellum-dependent cell motility
IC757_09190	COG1815	bacterial-type flagellum-dependent cell motility
IC757_09215	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IC757_09230	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IC757_09240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IC757_09245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IC757_09255	COG0505	Belongs to the CarA family
IC757_09265	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IC757_09275	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IC757_09280	COG1162	GTPase activity
IC757_09310	COG2957	Belongs to the agmatine deiminase family
IC757_09315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IC757_09320	COG2249	NAD(P)H dehydrogenase (quinone) activity
IC757_09345	COG1757	Na H antiporter
IC757_09375	COG0668	transmembrane transport
IC757_09380	COG1472	Belongs to the glycosyl hydrolase 3 family
IC757_09385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IC757_09405	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IC757_09410	COG3706	GGDEF domain
IC757_09420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IC757_09425	COG1063	alcohol dehydrogenase
IC757_09430	COG0156	8-amino-7-oxononanoate synthase activity
IC757_09440	COG4221	oxidoreductase activity
IC757_09445	COG1288	antiporter activity
IC757_09465	COG4221	oxidoreductase activity
IC757_09475	COG1309	transcriptional regulator
IC757_09520	COG0508	dehydrogenase complex catalyzes the overall conversion of
IC757_09525	COG4067	protein conserved in archaea
IC757_09525	COG0189	ligase activity
IC757_09530	COG0189	ligase activity
IC757_09555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IC757_09570	COG1850	ribulose-bisphosphate carboxylase activity
IC757_09575	COG1607	acyl-coa hydrolase
IC757_09580	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IC757_09585	COG0450	alkyl hydroperoxide reductase
IC757_09590	COG0583	DNA-binding transcription factor activity
IC757_09615	COG1131	(ABC) transporter
IC757_09625	COG2706	6-phosphogluconolactonase activity
IC757_09670	COG0372	Belongs to the citrate synthase family
IC757_09675	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IC757_09705	COG1960	acyl-CoA dehydrogenase activity
IC757_09715	COG1217	gtp-binding protein TYPA
IC757_09735	COG1946	Acyl-CoA thioesterase
IC757_09745	COG0039	L-malate dehydrogenase activity
IC757_09750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IC757_09755	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IC757_09770	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IC757_09775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IC757_09780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IC757_09815	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IC757_09820	COG2986	histidine ammonia-lyase
IC757_09825	COG1228	amidohydrolase
IC757_09840	COG0515	serine threonine protein kinase
IC757_09840	COG2815	serine threonine protein kinase
IC757_09845	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IC757_09860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IC757_09865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IC757_09870	COG1862	Preprotein translocase
IC757_09880	COG0515	serine threonine protein kinase
IC757_09885	COG0343	queuine tRNA-ribosyltransferase activity
IC757_09890	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IC757_09905	COG0463	Glycosyl transferase, family 2
IC757_09910	COG1404	Belongs to the peptidase S8 family
IC757_09925	COG4133	protoheme IX ABC transporter activity
IC757_09935	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IC757_09945	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IC757_09950	COG1138	Cytochrome C-type biogenesis protein
IC757_09955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IC757_09960	COG3088	subunit of a heme lyase
IC757_09990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IC757_10000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IC757_10010	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IC757_10015	COG1805	sodium ion transport
IC757_10020	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IC757_10030	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IC757_10035	COG2871	sodium ion transport
IC757_10040	COG1477	protein flavinylation
IC757_10070	COG0840	transmembrane signaling receptor activity
IC757_10095	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IC757_10115	COG0287	Prephenate dehydrogenase
IC757_10115	COG1605	Chorismate mutase
IC757_10125	COG3706	GGDEF domain
IC757_10140	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IC757_10145	COG0489	protein tyrosine kinase activity
IC757_10165	COG0640	Transcriptional regulator
IC757_10190	COG1960	acyl-CoA dehydrogenase activity
IC757_10195	COG0471	metal ion transport
IC757_10195	COG3273	potassium ion transport
IC757_10200	COG0183	Belongs to the thiolase family
IC757_10210	COG1127	ABC transporter
IC757_10215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IC757_10220	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IC757_10245	COG0339	signal peptide processing
IC757_10250	COG0405	Gamma-glutamyltransferase
IC757_10255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IC757_10260	COG0742	ribosomal rna small subunit methyltransferase
IC757_10265	COG0552	protein localization to endoplasmic reticulum
IC757_10270	COG1194	a g-specific adenine glycosylase
IC757_10275	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IC757_10290	COG5001	Diguanylate cyclase
IC757_10295	COG2890	protein-(glutamine-N5) methyltransferase activity
IC757_10305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IC757_10330	COG3237	CsbD-like
IC757_10345	COG0671	phosphoesterase, PA-phosphatase related
IC757_10365	COG0477	Major facilitator Superfamily
IC757_10370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IC757_10370	COG1703	isobutyryl-CoA mutase activity
IC757_10370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IC757_10375	COG0640	Transcriptional regulator
IC757_10380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IC757_10395	COG0745	RESPONSE REGULATOR receiver
IC757_10400	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IC757_10400	COG2199	diguanylate cyclase activity
IC757_10405	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IC757_10405	COG2199	diguanylate cyclase activity
IC757_10410	COG3590	peptidase
IC757_10415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IC757_10415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IC757_10420	COG4657	Part of a membrane complex involved in electron transport
IC757_10440	COG1429	ligase activity, forming nitrogen-metal bonds
IC757_10445	COG4771	TonB-dependent receptor
IC757_10475	COG2878	Part of a membrane complex involved in electron transport
IC757_10485	COG4658	electron transport chain
IC757_10540	COG1468	defense response to virus
IC757_10540	COG1518	maintenance of DNA repeat elements
IC757_10545	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IC757_10570	COG4659	FMN binding
IC757_10575	COG4660	Part of a membrane complex involved in electron transport
IC757_10580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IC757_10590	COG3220	belongs to the UPF0276 family
IC757_10615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IC757_10630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IC757_10640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IC757_10650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IC757_10680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC757_10695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IC757_10720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IC757_10730	COG0544	peptidyl-prolyl cis-trans isomerase activity
IC757_10775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IC757_10780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IC757_10790	COG2137	regulation of response to DNA damage stimulus
IC757_10795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IC757_10805	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IC757_10820	COG1546	Belongs to the CinA family
IC757_10825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IC757_10830	COG0515	serine threonine protein kinase
IC757_10830	COG2815	serine threonine protein kinase
IC757_10840	COG0802	atpase or kinase
IC757_10845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IC757_10845	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IC757_10865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IC757_10875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IC757_10885	COG0704	Plays a role in the regulation of phosphate uptake
IC757_10890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IC757_10895	COG0581	inorganic phosphate transmembrane transporter activity
IC757_10930	COG0735	belongs to the Fur family
IC757_10935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IC757_10940	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IC757_10945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IC757_10960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IC757_10965	COG2165	general secretion pathway protein
IC757_11030	COG4974	Belongs to the 'phage' integrase family
IC757_11080	COG3209	COG3209 Rhs family protein
IC757_11120	COG0640	Transcriptional regulator
IC757_11130	COG1410	methionine synthase
IC757_11130	COG0646	methionine synthase
IC757_11155	COG1131	(ABC) transporter
IC757_11170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IC757_11175	COG2897	thiosulfate sulfurtransferase activity
IC757_11180	COG2391	methyltransferase activity
IC757_11230	COG1051	belongs to the nudix hydrolase family
IC757_11245	COG0436	Aminotransferase
IC757_11255	COG0587	DNA-directed DNA polymerase activity
IC757_11285	COG0446	pyridine nucleotide-disulphide oxidoreductase
IC757_11285	COG1902	pentaerythritol trinitrate reductase activity
IC757_11295	COG0515	serine threonine protein kinase
IC757_11295	COG2815	serine threonine protein kinase
IC757_11305	COG1309	transcriptional regulator
IC757_11310	COG1960	acyl-CoA dehydrogenase activity
IC757_11315	COG1024	Enoyl-CoA hydratase
IC757_11315	COG1250	3-hydroxyacyl-CoA dehydrogenase
IC757_11320	COG0183	Belongs to the thiolase family
IC757_11325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IC757_11325	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IC757_11335	COG2154	pterin-4-alpha-carbinolamine dehydratase
IC757_11340	COG0714	Associated with various cellular activities
IC757_11360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IC757_11365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IC757_11370	COG2833	Protein of unknown function (DUF455)
IC757_11385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IC757_11390	COG1960	acyl-CoA dehydrogenase activity
IC757_11420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IC757_11425	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IC757_11435	COG0776	regulation of translation
IC757_11445	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IC757_11450	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IC757_11460	COG1605	Chorismate mutase
IC757_11460	COG0077	Prephenate dehydratase
IC757_11465	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IC757_11470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IC757_11480	COG0330	HflC and HflK could
IC757_11485	COG0330	HflC and HflK could
IC757_11490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IC757_11495	COG1923	regulation of RNA biosynthetic process
IC757_11500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IC757_11505	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IC757_11510	COG0625	glutathione transferase activity
IC757_11520	COG2885	chlorophyll binding
IC757_11545	COG0626	cystathionine gamma-synthase activity
IC757_11555	COG0585	pseudouridine synthase activity
IC757_11565	COG0745	RESPONSE REGULATOR receiver
IC757_11570	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IC757_11575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IC757_11580	COG3549	Plasmid maintenance system killer
IC757_11600	COG3695	enzyme binding
IC757_11605	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IC757_11620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IC757_11625	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IC757_11630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IC757_11635	COG0195	Participates in both transcription termination and antitermination
IC757_11635	COG2251	uridine kinase activity
IC757_11640	COG0779	Required for maturation of 30S ribosomal subunits
IC757_11660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IC757_11665	COG2010	Cytochrome c
IC757_11665	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IC757_11680	COG1506	peptidase
IC757_11680	COG0823	Involved in the tonB-independent uptake of proteins
IC757_11680	COG4946	Tricorn protease homolog
IC757_11690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IC757_11700	COG0822	iron-sulfur transferase activity
IC757_11710	COG1012	belongs to the aldehyde dehydrogenase family
IC757_11715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IC757_11720	COG0719	Fe-S assembly protein
IC757_11725	COG0396	ATPase activity
IC757_11730	COG0719	Fe-S assembly protein
IC757_11735	COG1959	2 iron, 2 sulfur cluster binding
IC757_11750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IC757_11755	COG3853	Toxic anion resistance protein (TelA)
IC757_11765	COG2268	Band 7 protein
IC757_11795	COG0367	asparagine synthase
IC757_11805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IC757_11815	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IC757_11820	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IC757_11850	COG0859	PFAM glycosyl transferase family 9
IC757_11865	COG1185	polyribonucleotide nucleotidyltransferase activity
IC757_11870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IC757_11875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IC757_11880	COG1024	Enoyl-CoA hydratase
IC757_11935	COG4948	Mandelate Racemase Muconate Lactonizing
IC757_11945	COG0542	response to heat
IC757_11950	COG1012	belongs to the aldehyde dehydrogenase family
IC757_11955	COG2096	Adenosyltransferase
IC757_11960	COG0123	including yeast histone deacetylase and acetoin utilization protein
IC757_11970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IC757_11985	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IC757_11990	COG1393	Belongs to the ArsC family
IC757_11995	COG2171	N-acyltransferase activity
IC757_12000	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IC757_12005	COG0024	Methionine aminopeptidase
IC757_12010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IC757_12030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IC757_12035	COG2971	BadF BadG BcrA BcrD
IC757_12045	COG1609	Transcriptional regulator
IC757_12055	COG0363	glucosamine-6-phosphate deaminase activity
IC757_12060	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IC757_12065	COG0363	glucosamine-6-phosphate deaminase activity
IC757_12085	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IC757_12105	COG2197	response regulator
IC757_12110	COG4585	Histidine kinase
IC757_12135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IC757_12165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IC757_12165	COG0543	2 iron, 2 sulfur cluster binding
IC757_12175	COG4269	membrane
IC757_12185	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IC757_12195	COG4771	TonB-dependent receptor
IC757_12215	COG2010	Cytochrome c
IC757_12220	COG4771	TonB-dependent receptor
IC757_12245	COG3848	Pyruvate phosphate dikinase
IC757_12245	COG0574	Belongs to the PEP-utilizing enzyme family
IC757_12260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IC757_12300	COG0616	signal peptide processing
IC757_12335	COG0589	response to stress
IC757_12340	COG0659	secondary active sulfate transmembrane transporter activity
IC757_12350	COG1404	Belongs to the peptidase S8 family
IC757_12405	COG0134	indole-3-glycerol-phosphate synthase activity
IC757_12410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IC757_12450	COG0134	indole-3-glycerol-phosphate synthase activity
IC757_12455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IC757_12460	COG0512	Glutamine amidotransferase of anthranilate synthase
IC757_12475	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IC757_12480	COG3307	-O-antigen
IC757_12490	COG1560	Kdo2-lipid A biosynthetic process
IC757_12495	COG1519	Transferase
IC757_12500	COG1538	Outer membrane efflux protein
IC757_12505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IC757_12510	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IC757_12530	COG0308	aminopeptidase N
IC757_12540	COG1956	GAF domain-containing protein
IC757_12605	COG0445	tRNA wobble uridine modification
IC757_12615	COG1115	amino acid carrier protein
IC757_12630	COG0616	signal peptide processing
IC757_12640	COG1666	GTP binding
IC757_12645	COG0006	proline dipeptidase activity
IC757_12650	COG0215	cysteine-tRNA ligase activity
IC757_12655	COG2166	iron-sulfur cluster assembly
IC757_12665	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IC757_12670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IC757_12675	COG0271	Belongs to the BolA IbaG family
IC757_12690	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IC757_12705	COG1137	ATPase activity
IC757_12710	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IC757_12745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IC757_12750	COG1214	PFAM Peptidase M22, glycoprotease
IC757_12755	COG1199	ATP-dependent helicase activity
IC757_12765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IC757_12770	COG0438	transferase activity, transferring glycosyl groups
IC757_12770	COG1216	Glycosyl transferase, family 2
IC757_12775	COG1216	Glycosyl transferase, family 2
IC757_12780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IC757_12790	COG1643	Atp-dependent helicase
IC757_12815	COG0427	acetyl-CoA hydrolase
IC757_12825	COG3094	Invasion gene expression up-regulator, SirB
IC757_12840	COG5001	Diguanylate cyclase
IC757_12880	COG0348	domain, Protein
IC757_12880	COG3901	Regulator of nitric oxide reductase transcription
IC757_12885	COG4263	nitrous-oxide reductase activity
IC757_12900	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IC757_12910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IC757_12935	COG2153	protein acetylation
IC757_12950	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IC757_12955	COG0288	reversible hydration of carbon dioxide
IC757_12960	COG0708	Exodeoxyribonuclease III
IC757_12965	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IC757_12970	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IC757_12975	COG0067	glutamate synthase
IC757_12975	COG0070	glutamate synthase
IC757_12975	COG0069	glutamate synthase activity
IC757_12990	COG0493	'glutamate synthase
IC757_13000	COG0116	Belongs to the methyltransferase superfamily
IC757_13000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IC757_13020	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IC757_13040	COG1309	transcriptional regulator
IC757_13050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IC757_13055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IC757_13060	COG0248	Ppx GppA phosphatase
IC757_13070	COG1073	alpha beta
IC757_13085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IC757_13095	COG3530	Putative quorum-sensing-regulated virulence factor
IC757_13105	COG1476	TRANSCRIPTIONal
IC757_13115	COG1131	(ABC) transporter
IC757_13120	COG1668	transmembrane transport
IC757_13125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IC757_13155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IC757_13170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IC757_13175	COG3938	Belongs to the proline racemase family
IC757_13185	COG3291	Pkd domain containing protein
IC757_13190	COG1228	amidohydrolase
IC757_13235	COG3177	Filamentation induced by cAMP protein fic
IC757_13275	COG3764	Sortase (surface protein transpeptidase)
IC757_13285	COG3447	MASE1 domain protein
IC757_13285	COG5001	Diguanylate cyclase
IC757_13285	COG5002	protein histidine kinase activity
IC757_13290	COG2823	Periplasmic or secreted lipoprotein
IC757_13300	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
IC757_13360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IC757_13365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IC757_13370	COG1216	Glycosyl transferase, family 2
IC757_13380	COG1215	transferase activity, transferring glycosyl groups
IC757_13455	COG1045	serine acetyltransferase
IC757_13460	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IC757_13490	COG0438	transferase activity, transferring glycosyl groups
IC757_13580	COG0628	permease
IC757_13585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IC757_13655	COG2885	chlorophyll binding
IC757_13700	COG0473	3-isopropylmalate dehydrogenase activity
IC757_13710	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IC757_13715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IC757_13720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IC757_13735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IC757_13740	COG0129	dihydroxy-acid dehydratase activity
IC757_13750	COG1074	ATP-dependent DNA helicase activity
IC757_13770	COG1007	ATP synthesis coupled electron transport
IC757_13790	COG0713	ATP synthesis coupled electron transport
IC757_13800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IC757_13805	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IC757_13810	COG1034	ATP synthesis coupled electron transport
IC757_13815	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IC757_13825	COG0649	NAD binding
IC757_13830	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IC757_13835	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IC757_13840	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IC757_13850	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IC757_13855	COG0149	triose-phosphate isomerase activity
IC757_13860	COG2353	YceI-like domain
IC757_13870	COG0312	modulator of DNA gyrase
IC757_13875	COG0312	modulator of DNA gyrase
IC757_13895	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IC757_13905	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IC757_13910	COG1466	dna polymerase III delta subunit
IC757_13920	COG0495	leucyl-tRNA aminoacylation
IC757_13930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IC757_13940	COG0071	Belongs to the small heat shock protein (HSP20) family
IC757_13945	COG2989	Protein conserved in bacteria
IC757_13970	COG1127	ABC transporter
IC757_13975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IC757_13985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IC757_13995	COG2814	Major facilitator Superfamily
IC757_14005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IC757_14015	COG3655	Transcriptional regulator
IC757_14030	COG2205	protein histidine kinase activity
IC757_14030	COG0784	Response regulator, receiver
IC757_14045	COG5002	protein histidine kinase activity
IC757_14050	COG0745	RESPONSE REGULATOR receiver
IC757_14055	COG5002	protein histidine kinase activity
IC757_14055	COG2176	DNA-directed DNA polymerase activity
IC757_14080	COG1360	Flagellar Motor Protein
IC757_14085	COG2183	response to ionizing radiation
IC757_14090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IC757_14100	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IC757_14100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IC757_14115	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IC757_14120	COG1446	asparaginase
IC757_14125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IC757_14150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IC757_14155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IC757_14160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IC757_14165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IC757_14185	COG1320	monovalent cation:proton antiporter activity
IC757_14200	COG1006	Multisubunit Na H antiporter MnhC subunit
IC757_14205	COG0651	ATP synthesis coupled electron transport
IC757_14210	COG0651	ATP synthesis coupled electron transport
IC757_14220	COG0651	ATP synthesis coupled electron transport
IC757_14235	COG0471	metal ion transport
IC757_14235	COG3273	potassium ion transport
IC757_14240	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IC757_14255	COG4221	oxidoreductase activity
IC757_14260	COG0840	transmembrane signaling receptor activity
IC757_14270	COG2135	peptidase activity
IC757_14300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IC757_14305	COG3409	Peptidoglycan-binding domain 1 protein
IC757_14305	COG3267	Type II secretory pathway component ExeA
IC757_14320	COG2165	general secretion pathway protein
IC757_14360	COG0515	serine threonine protein kinase
IC757_14365	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IC757_14370	COG1136	(ABC) transporter
IC757_14370	COG0577	efflux transmembrane transporter activity
IC757_14375	COG1136	(ABC) transporter
IC757_14375	COG0577	efflux transmembrane transporter activity
IC757_14385	COG5000	phosphorelay sensor kinase activity
IC757_14405	COG2234	aminopeptidase activity
IC757_14410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IC757_14485	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IC757_14500	COG1960	acyl-CoA dehydrogenase activity
IC757_14505	COG4206	TonB-dependent receptor
IC757_14525	COG2151	metal-sulfur cluster biosynthetic enzyme
IC757_14530	COG0308	aminopeptidase N
IC757_14540	COG0347	Belongs to the P(II) protein family
IC757_14555	COG1215	transferase activity, transferring glycosyl groups
IC757_14590	COG0606	chelatase, subunit chli
IC757_14645	COG2801	Transposase and inactivated derivatives
IC757_14680	COG0606	chelatase, subunit chli
IC757_14700	COG2911	Protein conserved in bacteria
IC757_14725	COG2217	Heavy metal translocating P-type atpase
IC757_14745	COG2010	Cytochrome c
IC757_14760	COG3278	Belongs to the heme-copper respiratory oxidase family
IC757_14770	COG1160	GTP binding
IC757_14775	COG1278	Cold shock
IC757_14790	COG0519	Catalyzes the synthesis of GMP from XMP
IC757_14795	COG4251	negative regulation of phosphorylation
IC757_14795	COG3706	GGDEF domain
IC757_14795	COG5001	Diguanylate cyclase
IC757_14795	COG2203	Gaf domain
IC757_14800	COG2095	MarC family integral membrane protein
IC757_14805	COG1506	peptidase
IC757_14805	COG0823	Involved in the tonB-independent uptake of proteins
IC757_14815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IC757_14830	COG0174	glutamine synthetase
IC757_14840	COG3852	Histidine kinase
IC757_14855	COG1136	(ABC) transporter
IC757_14870	COG1490	D-aminoacyl-tRNA deacylase activity
IC757_14895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IC757_14900	COG0569	domain protein
IC757_14905	COG2204	response regulator
IC757_14910	COG5000	phosphorelay sensor kinase activity
IC757_14920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IC757_14920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IC757_14925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IC757_14930	COG0242	peptide deformylase activity
IC757_14940	COG0758	DNA mediated transformation
IC757_14945	COG2922	Belongs to the Smg family
IC757_14950	COG1754	DNA topoisomerase type I activity
IC757_14950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IC757_14955	COG0408	coproporphyrinogen oxidase activity
IC757_14975	COG1228	amidohydrolase
IC757_14980	COG0402	S-adenosylhomocysteine deaminase activity
IC757_14990	COG3145	DNA-N1-methyladenine dioxygenase activity
IC757_15005	COG1917	Cupin 2, conserved barrel domain protein
IC757_15010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IC757_15015	COG0456	acetyltransferase
IC757_15060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IC757_15070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IC757_15080	COG0514	ATP-dependent DNA helicase (RecQ)
IC757_15095	COG1051	belongs to the nudix hydrolase family
IC757_15100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IC757_15105	COG1120	ATPase activity
IC757_15120	COG0617	tRNA 3'-terminal CCA addition
IC757_15125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IC757_15135	COG0730	response to heat
IC757_15155	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IC757_15165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IC757_15170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IC757_15175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IC757_15195	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IC757_15200	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IC757_15210	COG0598	Magnesium transport protein CorA
IC757_15240	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IC757_15250	COG1331	Highly conserved protein containing a thioredoxin domain
IC757_15260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IC757_15265	COG0471	metal ion transport
IC757_15265	COG3273	potassium ion transport
IC757_15295	COG2409	Drug exporters of the RND superfamily
IC757_15335	COG0471	metal ion transport
IC757_15335	COG0490	domain, Protein
IC757_15340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IC757_15350	COG0508	dehydrogenase complex catalyzes the overall conversion of
IC757_15365	COG2815	serine threonine protein kinase
IC757_15365	COG0515	serine threonine protein kinase
IC757_15440	COG3588	fructose-bisphosphate aldolase
IC757_15445	COG0469	pyruvate kinase activity
IC757_15450	COG4191	Histidine kinase
IC757_15450	COG0784	Response regulator, receiver
IC757_15455	COG1506	peptidase
IC757_15455	COG0823	Involved in the tonB-independent uptake of proteins
IC757_15455	COG4946	Tricorn protease homolog
IC757_15460	COG0625	glutathione transferase activity
IC757_15470	COG2205	protein histidine kinase activity
IC757_15470	COG4191	Histidine kinase
IC757_15470	COG0745	RESPONSE REGULATOR receiver
IC757_15475	COG0745	RESPONSE REGULATOR receiver
IC757_15510	COG3458	cephalosporin-C deacetylase activity
IC757_15530	COG1136	(ABC) transporter
IC757_15545	COG1595	DNA-templated transcription, initiation
IC757_15580	COG0126	phosphoglycerate kinase activity
IC757_15585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IC757_15590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IC757_15610	COG0642	Histidine kinase
IC757_15615	COG0745	RESPONSE REGULATOR receiver
IC757_15630	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IC757_15640	COG0762	integral membrane protein
IC757_15650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IC757_15670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IC757_15680	COG3909	cytochrome
IC757_15685	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
IC757_15695	COG4946	Tricorn protease homolog
IC757_15695	COG0793	Belongs to the peptidase S41A family
IC757_15725	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IC757_15750	COG0517	IMP dehydrogenase activity
IC757_15755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IC757_15760	COG0028	Belongs to the TPP enzyme family
IC757_15765	COG1304	FMN binding
IC757_15780	COG0521	Mo-molybdopterin cofactor biosynthetic process
IC757_15785	COG0303	'Molybdopterin
IC757_15790	COG3005	denitrification pathway
IC757_15800	COG0243	molybdopterin cofactor binding
IC757_15810	COG2878	Part of a membrane complex involved in electron transport
IC757_15815	COG4459	periplasmic nitrate reductase
IC757_15825	COG0315	cyclic pyranopterin monophosphate synthase activity
IC757_15840	COG0314	molybdopterin synthase activity
IC757_15870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IC757_15910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IC757_15915	COG4191	Histidine kinase
IC757_15920	COG4566	intracellular signal transduction
IC757_15930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IC757_15940	COG4772	TonB-dependent receptor
IC757_15945	COG0826	peptidase U32
IC757_15950	COG0826	peptidase U32
IC757_15960	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IC757_15965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IC757_15965	COG0674	pyruvate-flavodoxin oxidoreductase activity
IC757_15970	COG1013	pyruvate-flavodoxin oxidoreductase activity
IC757_15985	COG0277	FAD linked oxidase domain protein
IC757_16000	COG1643	Atp-dependent helicase
IC757_16010	COG0668	transmembrane transport
IC757_16020	COG0583	DNA-binding transcription factor activity
IC757_16025	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IC757_16035	COG3154	lipid carrier protein
IC757_16060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IC757_16085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IC757_16105	COG1612	heme a metabolic process
IC757_16110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IC757_16120	COG1121	(ABC) transporter
IC757_16150	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IC757_16155	COG1166	arginine decarboxylase activity
IC757_16160	COG2084	Dehydrogenase
IC757_16165	COG1115	amino acid carrier protein
IC757_16175	COG0018	arginyl-trna synthetase
IC757_16180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IC757_16185	COG0656	L-ascorbic acid biosynthetic process
IC757_16195	COG0330	HflC and HflK could
IC757_16210	COG1404	Belongs to the peptidase S8 family
IC757_16215	COG0842	Transport permease protein
IC757_16220	COG1131	(ABC) transporter
IC757_16230	COG4555	ABC transporter
IC757_16235	COG1668	transmembrane transport
IC757_16265	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IC757_16270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IC757_16275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IC757_16280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IC757_16280	COG0131	Imidazoleglycerol-phosphate dehydratase
IC757_16285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IC757_16290	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IC757_16305	COG1402	creatininase
IC757_16315	COG5001	Diguanylate cyclase
IC757_16315	COG5002	protein histidine kinase activity
IC757_16320	COG1376	ErfK ybiS ycfS ynhG family protein
IC757_16370	COG3039	Transposase
IC757_16400	COG3344	reverse transcriptase
IC757_16410	COG3344	reverse transcriptase
IC757_16420	COG3344	reverse transcriptase
IC757_16425	COG1598	PFAM Uncharacterised protein family UPF0150
IC757_16445	COG3039	Transposase
IC757_16465	COG3344	reverse transcriptase
IC757_16510	COG3344	reverse transcriptase
IC757_16550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IC757_16555	COG0352	thiamine-phosphate diphosphorylase activity
IC757_16565	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IC757_16575	COG0210	DNA helicase
IC757_16585	COG0583	DNA-binding transcription factor activity
IC757_16595	COG0435	Glutathione S-transferase
IC757_16600	COG3001	Fructosamine kinase
IC757_16605	COG0517	IMP dehydrogenase activity
IC757_16610	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IC757_16615	COG0488	(ABC) transporter
IC757_16620	COG0706	membrane insertase activity
IC757_16630	COG0230	Belongs to the bacterial ribosomal protein bL34 family