locus-tag	class	description
MIS46_00010	COG0592	DNA-directed DNA polymerase activity
MIS46_00055	COG0617	tRNA 3'-terminal CCA addition
MIS46_00065	COG1047	Peptidyl-prolyl cis-trans
MIS46_00080	COG0730	response to heat
MIS46_00110	COG1335	isochorismatase
MIS46_00115	COG0697	spore germination
MIS46_00140	COG2116	formate transmembrane transporter activity
MIS46_00150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MIS46_00190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MIS46_00200	COG0201	protein transport
MIS46_00205	COG0200	Binds to the 23S rRNA
MIS46_00260	COG1473	amidohydrolase
MIS46_00290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MIS46_00295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MIS46_00350	COG1279	arginine transmembrane transporter activity
MIS46_00365	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MIS46_00390	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MIS46_00395	COG0471	metal ion transport
MIS46_00475	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MIS46_00480	COG0116	Belongs to the methyltransferase superfamily
MIS46_00480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MIS46_00485	COG0557	exoribonuclease II activity
MIS46_00490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MIS46_00495	COG1476	TRANSCRIPTIONal
MIS46_00530	COG0038	chloride channel
MIS46_00545	COG2194	sulfuric ester hydrolase activity
MIS46_00550	COG1012	belongs to the aldehyde dehydrogenase family
MIS46_00555	COG0859	PFAM glycosyl transferase family 9
MIS46_00640	COG2884	Cell division ATP-binding protein ftsE
MIS46_00645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MIS46_00650	COG4452	Inner membrane protein CreD
MIS46_00655	COG0745	RESPONSE REGULATOR receiver
MIS46_00660	COG2205	protein histidine kinase activity
MIS46_00665	COG0758	DNA mediated transformation
MIS46_00665	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MIS46_00785	COG1690	Belongs to the RtcB family
MIS46_00800	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MIS46_00805	COG0142	geranyltranstransferase activity
MIS46_00830	COG0142	geranyltranstransferase activity
MIS46_00835	COG2707	UPF0756 membrane protein
MIS46_00875	COG0393	Putative heavy-metal-binding
MIS46_00880	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MIS46_00920	COG3263	regulation of cellular component size
MIS46_00925	COG1702	phosphate starvation-inducible protein PhoH
MIS46_00930	COG1115	amino acid carrier protein
MIS46_00960	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
MIS46_00975	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MIS46_00975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MIS46_00985	COG1132	(ABC) transporter
MIS46_01000	COG1538	Outer membrane efflux protein
MIS46_01020	COG2304	oxidoreductase activity
MIS46_01075	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MIS46_01115	COG0628	permease
MIS46_01175	COG2259	Doxx family
MIS46_01180	COG4783	chaperone-mediated protein folding
MIS46_01185	COG0393	Putative heavy-metal-binding
MIS46_01190	COG0393	Putative heavy-metal-binding
MIS46_01205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MIS46_01245	COG0494	nUDIX hydrolase
MIS46_01270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MIS46_01285	COG1216	Glycosyl transferase, family 2
MIS46_01305	COG2954	triphosphatase activity
MIS46_01320	COG3739	integral membrane protein
MIS46_01325	COG0800	Aldolase
MIS46_01350	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MIS46_01390	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
MIS46_01405	COG2852	Protein conserved in bacteria
MIS46_01450	COG1335	isochorismatase
MIS46_01465	COG1979	alcohol dehydrogenase
MIS46_01480	COG0514	ATP-dependent DNA helicase (RecQ)
MIS46_01490	COG0840	transmembrane signaling receptor activity
MIS46_01500	COG0840	transmembrane signaling receptor activity
MIS46_01520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MIS46_01525	COG2235	arginine
MIS46_01555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MIS46_01600	COG2233	PERMEase
MIS46_01665	COG0339	signal peptide processing
MIS46_01695	COG0826	peptidase U32
MIS46_01700	COG1476	TRANSCRIPTIONal
MIS46_01715	COG1216	Glycosyl transferase, family 2
MIS46_01780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MIS46_01815	COG1268	BioY protein
MIS46_01825	COG0523	cobalamin synthesis protein
MIS46_01845	COG2911	Protein conserved in bacteria
MIS46_01880	COG1399	metal-binding, possibly nucleic acid-binding protein
MIS46_01930	COG1490	D-aminoacyl-tRNA deacylase activity
MIS46_01935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MIS46_01940	COG0251	oxidation-reduction process
MIS46_01945	COG1519	Transferase
MIS46_01960	COG0626	cystathionine gamma-synthase activity
MIS46_01975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MIS46_01985	COG2239	Acts as a magnesium transporter
MIS46_01995	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MIS46_02020	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MIS46_02020	COG0037	tRNA processing
MIS46_02040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MIS46_02045	COG1522	sequence-specific DNA binding
MIS46_02070	COG1115	amino acid carrier protein
MIS46_02085	COG2201	protein-glutamate methylesterase activity
MIS46_02090	COG0643	Histidine kinase
MIS46_02090	COG2198	Histidine kinase
MIS46_02105	COG0356	it plays a direct role in the translocation of protons across the membrane
MIS46_02160	COG4650	regulator
MIS46_02185	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
MIS46_02210	COG2321	neutral zinc metallopeptidase
MIS46_02285	COG2267	carboxylic ester hydrolase activity
MIS46_02295	COG0795	lipopolysaccharide-transporting ATPase activity
MIS46_02315	COG0793	Belongs to the peptidase S41A family
MIS46_02320	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MIS46_02330	COG0824	Thioesterase
MIS46_02360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MIS46_02365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MIS46_02375	COG1127	ABC transporter
MIS46_02410	COG1811	Na channel or pump
MIS46_02420	COG0406	alpha-ribazole phosphatase activity
MIS46_02475	COG0723	plastoquinol--plastocyanin reductase activity
MIS46_02480	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MIS46_02485	COG2857	Cytochrome c1
MIS46_02575	COG0268	Binds directly to 16S ribosomal RNA
MIS46_02580	COG2824	Alkylphosphonate utilization operon protein PhnA
MIS46_02610	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MIS46_02620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MIS46_02685	COG4150	thiosulfate binding
MIS46_02695	COG4208	sulfate ABC transporter
MIS46_02715	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MIS46_02725	COG0471	metal ion transport
MIS46_02750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MIS46_02755	COG0305	Participates in initiation and elongation during chromosome replication
MIS46_02800	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MIS46_02865	COG3278	Belongs to the heme-copper respiratory oxidase family
MIS46_02880	COG2010	Cytochrome c
MIS46_02895	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MIS46_02900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MIS46_02965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MIS46_02970	COG2841	Protein conserved in bacteria
MIS46_03000	COG2350	Protein conserved in bacteria
MIS46_03015	COG0429	hydrolase of the alpha beta-hydrolase fold
MIS46_03060	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MIS46_03065	COG0123	including yeast histone deacetylase and acetoin utilization protein
MIS46_03085	COG0428	transporter
MIS46_03120	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MIS46_03130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MIS46_03135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MIS46_03165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MIS46_03170	COG0741	lytic transglycosylase activity
MIS46_03170	COG1388	LysM domain
MIS46_03170	COG1388	LysM domain
MIS46_03170	COG0741	lytic transglycosylase activity
MIS46_03220	COG0513	Belongs to the DEAD box helicase family
MIS46_03225	COG2878	Part of a membrane complex involved in electron transport
MIS46_03235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MIS46_03280	COG4615	Cyclic peptide transporter
MIS46_03325	COG1177	transmembrane transport
MIS46_03330	COG1176	ABC-type spermidine putrescine transport system, permease component I
MIS46_03335	COG3842	ATPase activity
MIS46_03340	COG0569	domain protein
MIS46_03355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MIS46_03405	COG0084	hydrolase, TatD family'
MIS46_03465	COG2995	paraquat-inducible protein a
MIS46_03480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MIS46_03500	COG0248	Ppx GppA phosphatase
MIS46_03565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MIS46_03595	COG0511	ligase activity, forming carbon-carbon bonds
MIS46_03605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MIS46_03610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MIS46_03615	COG1620	l-lactate permease
MIS46_03620	COG1139	Iron-sulfur cluster binding protein
MIS46_03630	COG0247	lactate metabolic process
MIS46_03635	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MIS46_03640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MIS46_03655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MIS46_03670	COG0024	Methionine aminopeptidase
MIS46_03695	COG2960	long-chain fatty acid transporting porin activity
MIS46_03715	COG1448	Aminotransferase
MIS46_03720	COG1757	Na H antiporter
MIS46_03770	COG1562	ergosterol biosynthetic process
MIS46_03790	COG5000	phosphorelay sensor kinase activity
MIS46_03795	COG2204	response regulator
MIS46_03800	COG2089	acid synthase
MIS46_03865	COG1929	Belongs to the glycerate kinase type-1 family
MIS46_03880	COG1643	Atp-dependent helicase
MIS46_03895	COG1943	Transposase
MIS46_03900	COG1643	Atp-dependent helicase
MIS46_03905	COG1401	restriction endodeoxyribonuclease activity
MIS46_03925	COG2610	gluconate transmembrane transporter activity
MIS46_03930	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
MIS46_03940	COG0366	Alpha amylase catalytic
MIS46_03955	COG1388	LysM domain
MIS46_03955	COG4942	peptidase
MIS46_03965	COG1686	Belongs to the peptidase S11 family
MIS46_03970	COG1408	metallophosphoesterase
MIS46_03990	COG0822	iron-sulfur transferase activity
MIS46_04025	COG1854	S-ribosylhomocysteine lyase activity
MIS46_04030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MIS46_04075	COG1686	Belongs to the peptidase S11 family
MIS46_04080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MIS46_04125	COG0318	PFAM AMP-dependent synthetase and ligase
MIS46_04200	COG4396	Host-nuclease inhibitor protein Gam
MIS46_04215	COG0776	regulation of translation
MIS46_04220	COG4382	Mu-like prophage protein Gp16
MIS46_04300	COG2369	cell adhesion
MIS46_04390	COG3392	D12 class N6 adenine-specific DNA methyltransferase
MIS46_04405	COG1652	LysM domain
MIS46_04420	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MIS46_04460	COG1619	proteins homologs of microcin C7 resistance protein MccF
MIS46_04470	COG1289	transmembrane transporter activity
MIS46_04475	COG1960	acyl-CoA dehydrogenase activity
MIS46_04480	COG2608	mercury ion transmembrane transporter activity
MIS46_04485	COG2217	Heavy metal translocating P-type atpase
MIS46_04505	COG1086	Polysaccharide biosynthesis protein
MIS46_04510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MIS46_04540	COG0714	Associated with various cellular activities
MIS46_04565	COG0285	dihydrofolate synthase activity
MIS46_04595	COG0737	Belongs to the 5'-nucleotidase family
MIS46_04600	COG2274	protein secretion by the type I secretion system
MIS46_04610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MIS46_04620	COG2814	Major facilitator Superfamily
MIS46_04625	COG2885	chlorophyll binding
MIS46_04640	COG0280	phosphate acetyltransferase
MIS46_04640	COG0857	belongs to the CobB CobQ family
MIS46_04660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MIS46_04660	COG2813	Specifically methylates the guanine in position
MIS46_04675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MIS46_04690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MIS46_04695	COG1194	a g-specific adenine glycosylase
MIS46_04700	COG0084	hydrolase, TatD family'
MIS46_04715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MIS46_04720	COG0436	Aminotransferase
MIS46_04735	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MIS46_04745	COG1063	alcohol dehydrogenase
MIS46_04750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIS46_04775	COG0210	DNA helicase
MIS46_04825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MIS46_04830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MIS46_04850	COG4589	Belongs to the CDS family
MIS46_04860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MIS46_04880	COG2354	Protein conserved in bacteria
MIS46_04915	COG1028	Short-chain dehydrogenase reductase Sdr
MIS46_04940	COG1999	signal sequence binding
MIS46_04955	COG4535	Mg2 and Co2 transporter CorC
MIS46_04970	COG4178	(ABC) transporter
MIS46_04980	COG0741	lytic transglycosylase activity
MIS46_04990	COG4989	oxidoreductase activity
MIS46_05000	COG3041	Addiction module toxin RelE StbE family
MIS46_05015	COG0786	glutamate:sodium symporter activity
MIS46_05025	COG2949	membrane
MIS46_05040	COG1560	Kdo2-lipid A biosynthetic process
MIS46_05075	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MIS46_05085	COG2807	transmembrane transport
MIS46_05100	COG0308	aminopeptidase N
MIS46_05125	COG0312	modulator of DNA gyrase
MIS46_05150	COG3111	PFAM Bacterial OB fold (BOF) protein
MIS46_05175	COG2070	2-Nitropropane dioxygenase
MIS46_05195	COG1113	amino acid transport
MIS46_05210	COG1561	YicC-like family, N-terminal region
MIS46_05225	COG0508	dehydrogenase complex catalyzes the overall conversion of
MIS46_05230	COG3042	response to heat
MIS46_05235	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MIS46_05255	COG0756	dUTP diphosphatase activity
MIS46_05285	COG1530	ribonuclease E activity
MIS46_05300	COG1426	Protein conserved in bacteria
MIS46_05315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIS46_05320	COG0105	UTP biosynthetic process
MIS46_05330	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MIS46_05335	COG1028	Short-chain dehydrogenase reductase Sdr
MIS46_05445	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MIS46_05465	COG0163	prenyltransferase activity
MIS46_05475	COG0489	protein tyrosine kinase activity
MIS46_05490	COG3045	CreA protein
MIS46_05495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MIS46_05500	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MIS46_05510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MIS46_05520	COG1862	Preprotein translocase
MIS46_05525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MIS46_05530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MIS46_05535	COG0492	ferredoxin-NADP+ reductase activity
MIS46_05560	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MIS46_05570	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MIS46_05575	COG1083	cytidylyl-transferase
MIS46_05580	COG4783	chaperone-mediated protein folding
MIS46_05600	COG2431	L-lysine efflux transmembrane transporter activity
MIS46_05605	COG1214	PFAM Peptidase M22, glycoprotease
MIS46_05635	COG0488	(ABC) transporter
MIS46_05645	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MIS46_05660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MIS46_05670	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MIS46_05675	COG0579	oxidoreductase
MIS46_05680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MIS46_05715	COG0708	Exodeoxyribonuclease III
MIS46_05725	COG1522	sequence-specific DNA binding
MIS46_05735	COG1131	(ABC) transporter
MIS46_05740	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MIS46_05745	COG0307	riboflavin synthase, alpha
MIS46_05790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MIS46_05815	COG1333	cytochrome c biogenesis protein
MIS46_05825	COG4969	Belongs to the N-Me-Phe pilin family
MIS46_05835	COG0028	Belongs to the TPP enzyme family
MIS46_05840	COG0440	acetolactate synthase activity
MIS46_05850	COG1187	pseudouridine synthase activity
MIS46_05860	COG2959	enzyme of heme biosynthesis
MIS46_05880	COG1959	2 iron, 2 sulfur cluster binding
MIS46_05905	COG0613	PHP domain protein
MIS46_05910	COG2839	Protein conserved in bacteria
MIS46_05920	COG4783	chaperone-mediated protein folding
MIS46_05980	COG0741	lytic transglycosylase activity
MIS46_05985	COG2999	glutathione oxidoreductase activity
MIS46_06005	COG0802	atpase or kinase
MIS46_06080	COG1217	gtp-binding protein TYPA
MIS46_06105	COG2944	sequence-specific DNA binding
MIS46_06125	COG3501	Rhs element vgr protein
MIS46_06255	COG1192	Involved in chromosome partitioning
MIS46_06310	COG0582	viral genome integration into host DNA
MIS46_06315	COG0582	viral genome integration into host DNA
MIS46_06335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MIS46_06355	COG0488	(ABC) transporter
MIS46_06375	COG1442	glycosyl transferase family 8
MIS46_06440	COG0586	Pfam SNARE associated Golgi protein
MIS46_06465	COG1085	galactose-1-phosphate uridylyltransferase
MIS46_06475	COG1129	ABC transporter
MIS46_06480	COG4211	Belongs to the binding-protein-dependent transport system permease family
MIS46_06500	COG1280	lysine exporter protein (LysE YggA)
MIS46_06535	COG0633	Ferredoxin
MIS46_06540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MIS46_06545	COG2195	Cleaves the N-terminal amino acid of tripeptides
MIS46_06555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MIS46_06565	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MIS46_06570	COG1794	racemase activity, acting on amino acids and derivatives
MIS46_06575	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MIS46_06595	COG1307	EDD domain protein, DegV family
MIS46_06600	COG1115	amino acid carrier protein
MIS46_06615	COG1199	ATP-dependent helicase activity
MIS46_06625	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MIS46_06635	COG0442	prolyl-tRNA aminoacylation
MIS46_06660	COG0805	protein transport
MIS46_06680	COG0697	spore germination
MIS46_06695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MIS46_06705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MIS46_06710	COG1970	mechanosensitive ion channel activity
MIS46_06725	COG0512	Glutamine amidotransferase of anthranilate synthase
MIS46_06735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MIS46_06745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MIS46_06765	COG0488	(ABC) transporter
MIS46_06770	COG0859	PFAM glycosyl transferase family 9
MIS46_06780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MIS46_06795	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
MIS46_06810	COG0488	(ABC) transporter
MIS46_06830	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MIS46_06835	COG1496	oxidoreductase activity
MIS46_06865	COG3038	cytochrome b561
MIS46_06870	COG0688	phosphatidylethanolamine metabolic process
MIS46_06880	COG0497	DNA recombination
MIS46_06940	COG1538	Outer membrane efflux protein
MIS46_06945	COG0577	efflux transmembrane transporter activity
MIS46_06945	COG1136	(ABC) transporter
MIS46_06950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MIS46_06975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MIS46_06990	COG1216	Glycosyl transferase, family 2
MIS46_06990	COG1442	glycosyl transferase family 8
MIS46_06995	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MIS46_07015	COG0557	exoribonuclease II activity
MIS46_07030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MIS46_07035	COG1178	ABC-type Fe3 transport system permease component
MIS46_07050	COG1902	pentaerythritol trinitrate reductase activity
MIS46_07050	COG0446	pyridine nucleotide-disulphide oxidoreductase
MIS46_07060	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MIS46_07065	COG1733	regulation of RNA biosynthetic process
MIS46_07135	COG0560	Phosphoserine phosphatase
MIS46_07140	COG1074	ATP-dependent DNA helicase activity
MIS46_07160	COG1045	serine acetyltransferase
MIS46_07195	COG0494	nUDIX hydrolase
MIS46_07200	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MIS46_07200	COG3264	Mechanosensitive ion channel
MIS46_07215	COG0633	Ferredoxin
MIS46_07245	COG2814	Major facilitator Superfamily
MIS46_07255	COG0575	Belongs to the CDS family
MIS46_07260	COG0252	asparaginase activity
MIS46_07270	COG1247	-acetyltransferase
MIS46_07285	COG3094	Invasion gene expression up-regulator, SirB
MIS46_07295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MIS46_07310	COG0513	Belongs to the DEAD box helicase family
MIS46_07315	COG3700	Belongs to the class B bacterial acid phosphatase family
MIS46_07320	COG0295	cytidine deaminase activity
MIS46_07325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MIS46_07330	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MIS46_07335	COG0813	purine-nucleoside phosphorylase activity
MIS46_07365	COG0531	amino acid
MIS46_07370	COG0705	Rhomboid family
MIS46_07370	COG0457	Tetratricopeptide repeat
MIS46_07380	COG0121	glutamine amidotransferase
MIS46_07395	COG3620	sequence-specific DNA binding
MIS46_07400	COG4735	regulation of single-species biofilm formation
MIS46_07425	COG1393	Belongs to the ArsC family
MIS46_07440	COG0433	COG0433 Predicted ATPase
MIS46_07450	COG0312	modulator of DNA gyrase
MIS46_07470	COG0280	phosphate acetyltransferase
MIS46_07470	COG0281	malic enzyme
MIS46_07535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MIS46_07535	COG3008	intermembrane lipid transfer
MIS46_07590	COG1077	Cell shape determining protein MreB Mrl
MIS46_07600	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MIS46_07605	COG0768	penicillin binding
MIS46_07610	COG0772	Belongs to the SEDS family
MIS46_07615	COG2095	MarC family integral membrane protein
MIS46_07670	COG0738	Major facilitator superfamily
MIS46_07680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MIS46_07690	COG1760	l-serine dehydratase
MIS46_07695	COG1196	nuclear chromosome segregation
MIS46_07700	COG2610	gluconate transmembrane transporter activity
MIS46_07705	COG3265	gluconokinase activity
MIS46_07735	COG3307	-O-antigen
MIS46_07745	COG0739	heme binding
MIS46_07865	COG1114	Component of the transport system for branched-chain amino acids
MIS46_07890	COG1505	serine-type exopeptidase activity
MIS46_07925	COG4977	sequence-specific DNA binding
MIS46_07935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MIS46_07955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MIS46_07960	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MIS46_07965	COG0778	Nitroreductase
MIS46_07985	COG1064	alcohol dehydrogenase
MIS46_08000	COG3335	DDE superfamily endonuclease
MIS46_08005	COG2189	Belongs to the N(4) N(6)-methyltransferase family
MIS46_08015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MIS46_08020	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MIS46_08040	COG1373	ATPase (AAA superfamily
MIS46_08065	COG2249	NAD(P)H dehydrogenase (quinone) activity
MIS46_08090	COG0583	DNA-binding transcription factor activity
MIS46_08095	COG1902	pentaerythritol trinitrate reductase activity
MIS46_08135	COG0583	DNA-binding transcription factor activity
MIS46_08140	COG1764	response to oxidative stress
MIS46_08145	COG3836	Belongs to the HpcH HpaI aldolase family
MIS46_08160	COG0778	Nitroreductase
MIS46_08175	COG1902	pentaerythritol trinitrate reductase activity
MIS46_08180	COG1902	pentaerythritol trinitrate reductase activity
MIS46_08185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MIS46_08220	COG1733	regulation of RNA biosynthetic process
MIS46_08225	COG0519	Catalyzes the synthesis of GMP from XMP
MIS46_08265	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MIS46_08275	COG0456	acetyltransferase
MIS46_08340	COG1442	glycosyl transferase family 8
MIS46_08340	COG1216	Glycosyl transferase, family 2
MIS46_08345	COG1575	Belongs to the MenA family. Type 1 subfamily
MIS46_08360	COG1216	Glycosyl transferase, family 2
MIS46_08365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MIS46_08385	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MIS46_08405	COG1137	ATPase activity
MIS46_08410	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MIS46_08415	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MIS46_08425	COG1192	Involved in chromosome partitioning
MIS46_08460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MIS46_08475	COG2390	Transcriptional regulator
MIS46_08485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MIS46_08505	COG2194	sulfuric ester hydrolase activity
MIS46_08565	COG1396	sequence-specific DNA binding
MIS46_08590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MIS46_08595	COG0859	PFAM glycosyl transferase family 9
MIS46_08600	COG2814	Major facilitator Superfamily
MIS46_08610	COG0501	Belongs to the peptidase M48B family
MIS46_08645	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MIS46_08665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MIS46_08665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MIS46_08670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MIS46_08675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MIS46_08680	COG0745	RESPONSE REGULATOR receiver
MIS46_08695	COG2223	nitrite transmembrane transporter activity
MIS46_08725	COG0814	amino acid
MIS46_08730	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MIS46_08745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MIS46_08750	COG1105	Belongs to the carbohydrate kinase PfkB family
MIS46_08770	COG0012	GTP binding
MIS46_08780	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MIS46_08795	COG2975	iron-sulfur cluster assembly
MIS46_08815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MIS46_08815	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MIS46_08845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MIS46_08860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MIS46_08865	COG0678	peroxiredoxin activity
MIS46_08865	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MIS46_08880	COG1278	Cold shock
MIS46_08890	COG0542	response to heat
MIS46_08900	COG0009	L-threonylcarbamoyladenylate synthase
MIS46_08910	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MIS46_08915	COG0237	dephospho-CoA kinase activity
MIS46_08940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MIS46_08945	COG2833	Protein of unknown function (DUF455)
MIS46_08970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MIS46_09005	COG1126	abc transporter atp-binding protein
MIS46_09010	COG0765	amino acid transport
MIS46_09015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIS46_09025	COG0778	Nitroreductase
MIS46_09055	COG0435	Glutathione S-transferase
MIS46_09145	COG0277	FAD linked oxidase domain protein
MIS46_09155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MIS46_09180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MIS46_09185	COG0583	DNA-binding transcription factor activity
MIS46_09245	COG1530	ribonuclease E activity
MIS46_09290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MIS46_09315	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
MIS46_09335	COG2189	Belongs to the N(4) N(6)-methyltransferase family
MIS46_09340	COG3421	Type III restriction
MIS46_09345	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MIS46_09355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MIS46_09360	COG0583	DNA-binding transcription factor activity
MIS46_09365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIS46_09395	COG0583	DNA-binding transcription factor activity
MIS46_09405	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MIS46_09410	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MIS46_09415	COG1984	allophanate hydrolase subunit 2
MIS46_09440	COG1914	H( )-stimulated, divalent metal cation uptake system
MIS46_09545	COG2056	Na+-H+ antiporter family
MIS46_09600	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MIS46_09640	COG0195	Participates in both transcription termination and antitermination
MIS46_09640	COG2251	uridine kinase activity
MIS46_09700	COG1564	THIamine pyrophosphokinase
MIS46_09725	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MIS46_09735	COG1183	phosphatidylcholine synthase activity
MIS46_10045	COG2217	Heavy metal translocating P-type atpase
MIS46_10050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MIS46_10055	COG0477	Major facilitator Superfamily
MIS46_10070	COG0697	spore germination
MIS46_10110	COG0477	Major facilitator Superfamily
MIS46_10115	COG2233	PERMEase
MIS46_10120	COG1765	OsmC-like protein
MIS46_10130	COG0330	HflC and HflK could
MIS46_10135	COG0625	glutathione transferase activity
MIS46_10140	COG2969	positive regulation of protein catabolic process
MIS46_10175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MIS46_10195	COG2837	iron assimilation
MIS46_10210	COG4589	Belongs to the CDS family
MIS46_10225	COG1120	ATPase activity
MIS46_10235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MIS46_10330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MIS46_10340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MIS46_10345	COG0287	Prephenate dehydrogenase
MIS46_10350	COG0765	amino acid transport
MIS46_10355	COG0196	riboflavin kinase activity
MIS46_10360	COG4604	ABC transporter, ATP-binding protein
MIS46_10365	COG1846	Transcriptional regulator
MIS46_10370	COG2193	ferroxidase activity
MIS46_10375	COG1764	response to oxidative stress
MIS46_10385	COG4605	iron ion homeostasis
MIS46_10395	COG1373	ATPase (AAA superfamily
MIS46_10405	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MIS46_10440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MIS46_10440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MIS46_10465	COG0424	maF-like protein
MIS46_10470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MIS46_10475	COG0799	negative regulation of ribosome biogenesis
MIS46_10485	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MIS46_10505	COG2951	lytic endotransglycosylase activity
MIS46_10510	COG3012	SEC-C Motif Domain Protein
MIS46_10595	COG3909	cytochrome
MIS46_10600	COG4221	oxidoreductase activity
MIS46_10610	COG4682	membrane
MIS46_10625	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MIS46_10635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MIS46_10640	COG2011	ABC-type metal ion transport system permease component
MIS46_10645	COG1464	Belongs to the NlpA lipoprotein family
MIS46_10660	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MIS46_10665	COG0561	phosphatase activity
MIS46_10690	COG0210	DNA helicase
MIS46_10695	COG2906	2 iron, 2 sulfur cluster binding
MIS46_10715	COG0586	Pfam SNARE associated Golgi protein
MIS46_10720	COG0612	Peptidase, M16
MIS46_10730	COG0753	catalase activity
MIS46_10735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MIS46_10770	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MIS46_10770	COG0616	signal peptide processing
MIS46_10780	COG1793	dna ligase
MIS46_10785	COG0583	DNA-binding transcription factor activity
MIS46_10805	COG4804	nuclease activity
MIS46_10830	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
MIS46_10865	COG2364	Membrane
MIS46_10895	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MIS46_10900	COG2866	Carboxypeptidase
MIS46_10905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MIS46_10910	COG1064	alcohol dehydrogenase
MIS46_10965	COG0542	response to heat
MIS46_10985	COG3977	Valine--pyruvate aminotransferase
MIS46_11000	COG0277	FAD linked oxidase domain protein
MIS46_11030	COG0288	reversible hydration of carbon dioxide
MIS46_11040	COG0803	Belongs to the bacterial solute-binding protein 9 family
MIS46_11045	COG0842	Transport permease protein
MIS46_11045	COG1129	ABC transporter
MIS46_11050	COG0842	Transport permease protein
MIS46_11060	COG1555	photosystem II stabilization
MIS46_11060	COG1596	polysaccharide export
MIS46_11075	COG2252	PERMEase
MIS46_11080	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MIS46_11115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MIS46_11125	COG2271	Major facilitator Superfamily
MIS46_11150	COG0519	Catalyzes the synthesis of GMP from XMP
MIS46_11150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MIS46_11155	COG1115	amino acid carrier protein
MIS46_11170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MIS46_11175	COG0469	pyruvate kinase activity
MIS46_11185	COG3842	ATPase activity
MIS46_11200	COG0346	lactoylglutathione lyase activity
MIS46_11205	COG0671	phosphoesterase, PA-phosphatase related
MIS46_11205	COG2453	phosphatase
MIS46_11210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MIS46_11220	COG1610	YqeY-like protein
MIS46_11235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MIS46_11240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIS46_11250	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MIS46_11270	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MIS46_11275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MIS46_11290	COG1297	OPT oligopeptide transporter protein
MIS46_11295	COG3738	Protein conserved in bacteria
MIS46_11345	COG1739	Uncharacterized protein family UPF0029
MIS46_11370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane