locus-tag	class	description
MIS45_00010	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MIS45_00020	COG0592	DNA-directed DNA polymerase activity
MIS45_00075	COG0617	tRNA 3'-terminal CCA addition
MIS45_00085	COG1047	Peptidyl-prolyl cis-trans
MIS45_00095	COG0730	response to heat
MIS45_00110	COG0741	lytic transglycosylase activity
MIS45_00150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MIS45_00150	COG0551	DNA topoisomerase type I activity
MIS45_00155	COG3736	Type IV secretory pathway, component VirB8
MIS45_00260	COG0582	viral genome integration into host DNA
MIS45_00280	COG1335	isochorismatase
MIS45_00285	COG0697	spore germination
MIS45_00310	COG2116	formate transmembrane transporter activity
MIS45_00320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MIS45_00360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MIS45_00370	COG0201	protein transport
MIS45_00375	COG0200	Binds to the 23S rRNA
MIS45_00430	COG1473	amidohydrolase
MIS45_00460	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MIS45_00465	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MIS45_00510	COG1279	arginine transmembrane transporter activity
MIS45_00540	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MIS45_00545	COG0471	metal ion transport
MIS45_00625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MIS45_00630	COG0116	Belongs to the methyltransferase superfamily
MIS45_00630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MIS45_00635	COG0557	exoribonuclease II activity
MIS45_00640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MIS45_00670	COG0038	chloride channel
MIS45_00685	COG2194	sulfuric ester hydrolase activity
MIS45_00690	COG1012	belongs to the aldehyde dehydrogenase family
MIS45_00695	COG0859	PFAM glycosyl transferase family 9
MIS45_00760	COG2884	Cell division ATP-binding protein ftsE
MIS45_00765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MIS45_00770	COG4452	Inner membrane protein CreD
MIS45_00775	COG0745	RESPONSE REGULATOR receiver
MIS45_00780	COG2205	protein histidine kinase activity
MIS45_00785	COG0758	DNA mediated transformation
MIS45_00850	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MIS45_00875	COG1690	Belongs to the RtcB family
MIS45_00890	COG0142	geranyltranstransferase activity
MIS45_00915	COG0142	geranyltranstransferase activity
MIS45_00920	COG2707	UPF0756 membrane protein
MIS45_00940	COG1609	Transcriptional regulator
MIS45_00960	COG0393	Putative heavy-metal-binding
MIS45_00965	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MIS45_01050	COG0628	permease
MIS45_01085	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MIS45_01100	COG1538	Outer membrane efflux protein
MIS45_01115	COG2304	oxidoreductase activity
MIS45_01180	COG1132	(ABC) transporter
MIS45_01190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MIS45_01190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MIS45_01205	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
MIS45_01230	COG4143	(ABC) transporter
MIS45_01235	COG1115	amino acid carrier protein
MIS45_01240	COG1702	phosphate starvation-inducible protein PhoH
MIS45_01245	COG3263	regulation of cellular component size
MIS45_01280	COG2259	Doxx family
MIS45_01285	COG4783	chaperone-mediated protein folding
MIS45_01290	COG0393	Putative heavy-metal-binding
MIS45_01295	COG0393	Putative heavy-metal-binding
MIS45_01310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MIS45_01350	COG0494	nUDIX hydrolase
MIS45_01375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MIS45_01390	COG1216	Glycosyl transferase, family 2
MIS45_01400	COG2954	triphosphatase activity
MIS45_01415	COG3739	integral membrane protein
MIS45_01420	COG0800	Aldolase
MIS45_01445	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MIS45_01490	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
MIS45_01510	COG2852	Protein conserved in bacteria
MIS45_01515	COG1034	ATP synthesis coupled electron transport
MIS45_01525	COG2852	Protein conserved in bacteria
MIS45_01570	COG1979	alcohol dehydrogenase
MIS45_01585	COG0514	ATP-dependent DNA helicase (RecQ)
MIS45_01610	COG0840	transmembrane signaling receptor activity
MIS45_01620	COG0840	transmembrane signaling receptor activity
MIS45_01630	COG1253	flavin adenine dinucleotide binding
MIS45_01640	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MIS45_01645	COG2235	arginine
MIS45_01675	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MIS45_01785	COG0339	signal peptide processing
MIS45_01815	COG0826	peptidase U32
MIS45_01835	COG1216	Glycosyl transferase, family 2
MIS45_01900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MIS45_01935	COG1268	BioY protein
MIS45_01945	COG0523	cobalamin synthesis protein
MIS45_01950	COG0463	Glycosyl transferase, family 2
MIS45_01970	COG2911	Protein conserved in bacteria
MIS45_02005	COG1399	metal-binding, possibly nucleic acid-binding protein
MIS45_02055	COG1490	D-aminoacyl-tRNA deacylase activity
MIS45_02060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MIS45_02065	COG0251	oxidation-reduction process
MIS45_02070	COG1519	Transferase
MIS45_02085	COG0626	cystathionine gamma-synthase activity
MIS45_02100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MIS45_02110	COG2239	Acts as a magnesium transporter
MIS45_02125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MIS45_02155	COG3676	manually curated
MIS45_02170	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MIS45_02175	COG1522	sequence-specific DNA binding
MIS45_02195	COG1115	amino acid carrier protein
MIS45_02210	COG2201	protein-glutamate methylesterase activity
MIS45_02215	COG2198	Histidine kinase
MIS45_02215	COG0643	Histidine kinase
MIS45_02230	COG0356	it plays a direct role in the translocation of protons across the membrane
MIS45_02300	COG4650	regulator
MIS45_02330	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
MIS45_02355	COG2321	neutral zinc metallopeptidase
MIS45_02430	COG2267	carboxylic ester hydrolase activity
MIS45_02440	COG0795	lipopolysaccharide-transporting ATPase activity
MIS45_02460	COG0793	Belongs to the peptidase S41A family
MIS45_02465	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MIS45_02475	COG0824	Thioesterase
MIS45_02505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MIS45_02510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MIS45_02520	COG1127	ABC transporter
MIS45_02555	COG1811	Na channel or pump
MIS45_02600	COG1070	Carbohydrate kinase
MIS45_02645	COG0723	plastoquinol--plastocyanin reductase activity
MIS45_02650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MIS45_02655	COG2857	Cytochrome c1
MIS45_02750	COG0268	Binds directly to 16S ribosomal RNA
MIS45_02755	COG2824	Alkylphosphonate utilization operon protein PhnA
MIS45_02785	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MIS45_02795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MIS45_02820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIS45_02855	COG4150	thiosulfate binding
MIS45_02865	COG4208	sulfate ABC transporter
MIS45_02875	COG0702	epimerase
MIS45_02900	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MIS45_02910	COG0471	metal ion transport
MIS45_02935	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MIS45_02940	COG0305	Participates in initiation and elongation during chromosome replication
MIS45_03070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MIS45_03075	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MIS45_03090	COG2010	Cytochrome c
MIS45_03105	COG3278	Belongs to the heme-copper respiratory oxidase family
MIS45_03155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MIS45_03165	COG2841	Protein conserved in bacteria
MIS45_03195	COG2350	Protein conserved in bacteria
MIS45_03210	COG0429	hydrolase of the alpha beta-hydrolase fold
MIS45_03255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MIS45_03260	COG0123	including yeast histone deacetylase and acetoin utilization protein
MIS45_03285	COG1388	LysM domain
MIS45_03285	COG0741	lytic transglycosylase activity
MIS45_03285	COG1388	LysM domain
MIS45_03285	COG0741	lytic transglycosylase activity
MIS45_03290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MIS45_03320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MIS45_03325	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MIS45_03335	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MIS45_03370	COG0428	transporter
MIS45_03410	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MIS45_03415	COG0513	Belongs to the DEAD box helicase family
MIS45_03420	COG2878	Part of a membrane complex involved in electron transport
MIS45_03510	COG0084	hydrolase, TatD family'
MIS45_03565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MIS45_03590	COG0569	domain protein
MIS45_03595	COG3842	ATPase activity
MIS45_03600	COG1176	ABC-type spermidine putrescine transport system, permease component I
MIS45_03605	COG1177	transmembrane transport
MIS45_03645	COG4615	Cyclic peptide transporter
MIS45_03675	COG2995	paraquat-inducible protein a
MIS45_03690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MIS45_03710	COG0248	Ppx GppA phosphatase
MIS45_03760	COG0733	neurotransmitter:sodium symporter activity
MIS45_03770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MIS45_03795	COG0511	ligase activity, forming carbon-carbon bonds
MIS45_03805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MIS45_03810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MIS45_03815	COG1620	l-lactate permease
MIS45_03820	COG1139	Iron-sulfur cluster binding protein
MIS45_03830	COG0247	lactate metabolic process
MIS45_03835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MIS45_03840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MIS45_03865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MIS45_03880	COG0024	Methionine aminopeptidase
MIS45_03905	COG2960	long-chain fatty acid transporting porin activity
MIS45_03915	COG1448	Aminotransferase
MIS45_03920	COG1757	Na H antiporter
MIS45_03970	COG1562	ergosterol biosynthetic process
MIS45_03990	COG5000	phosphorelay sensor kinase activity
MIS45_03995	COG2204	response regulator
MIS45_04000	COG2089	acid synthase
MIS45_04060	COG1929	Belongs to the glycerate kinase type-1 family
MIS45_04075	COG1643	Atp-dependent helicase
MIS45_04095	COG1943	Transposase
MIS45_04100	COG1643	Atp-dependent helicase
MIS45_04105	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MIS45_04130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIS45_04165	COG0366	Alpha amylase catalytic
MIS45_04175	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
MIS45_04180	COG2610	gluconate transmembrane transporter activity
MIS45_04215	COG1388	LysM domain
MIS45_04215	COG4942	peptidase
MIS45_04225	COG1686	Belongs to the peptidase S11 family
MIS45_04230	COG1408	metallophosphoesterase
MIS45_04245	COG0822	iron-sulfur transferase activity
MIS45_04280	COG1854	S-ribosylhomocysteine lyase activity
MIS45_04285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MIS45_04310	COG1686	Belongs to the peptidase S11 family
MIS45_04315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MIS45_04375	COG0318	PFAM AMP-dependent synthetase and ligase
MIS45_04380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIS45_04385	COG1652	LysM domain
MIS45_04395	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MIS45_04405	COG1619	proteins homologs of microcin C7 resistance protein MccF
MIS45_04415	COG1289	transmembrane transporter activity
MIS45_04420	COG1960	acyl-CoA dehydrogenase activity
MIS45_04425	COG2608	mercury ion transmembrane transporter activity
MIS45_04430	COG2217	Heavy metal translocating P-type atpase
MIS45_04455	COG0285	dihydrofolate synthase activity
MIS45_04485	COG0737	Belongs to the 5'-nucleotidase family
MIS45_04490	COG1943	Transposase
MIS45_04505	COG2274	protein secretion by the type I secretion system
MIS45_04515	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MIS45_04520	COG2814	Major facilitator Superfamily
MIS45_04525	COG2885	chlorophyll binding
MIS45_04540	COG0857	belongs to the CobB CobQ family
MIS45_04540	COG0280	phosphate acetyltransferase
MIS45_04545	COG1971	Probably functions as a manganese efflux pump
MIS45_04560	COG2813	Specifically methylates the guanine in position
MIS45_04560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MIS45_04575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MIS45_04590	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MIS45_04595	COG1194	a g-specific adenine glycosylase
MIS45_04600	COG0084	hydrolase, TatD family'
MIS45_04615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MIS45_04620	COG0436	Aminotransferase
MIS45_04640	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MIS45_04650	COG1063	alcohol dehydrogenase
MIS45_04655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIS45_04680	COG0210	DNA helicase
MIS45_04730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MIS45_04735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MIS45_04755	COG4589	Belongs to the CDS family
MIS45_04775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MIS45_04795	COG2354	Protein conserved in bacteria
MIS45_04810	COG1028	Short-chain dehydrogenase reductase Sdr
MIS45_04835	COG1999	signal sequence binding
MIS45_04850	COG4535	Mg2 and Co2 transporter CorC
MIS45_04865	COG4178	(ABC) transporter
MIS45_04875	COG0741	lytic transglycosylase activity
MIS45_04885	COG4989	oxidoreductase activity
MIS45_04895	COG3041	Addiction module toxin RelE StbE family
MIS45_04915	COG0786	glutamate:sodium symporter activity
MIS45_04925	COG2949	membrane
MIS45_04940	COG1560	Kdo2-lipid A biosynthetic process
MIS45_04975	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MIS45_04985	COG2807	transmembrane transport
MIS45_04995	COG0308	aminopeptidase N
MIS45_05010	COG0312	modulator of DNA gyrase
MIS45_05035	COG3111	PFAM Bacterial OB fold (BOF) protein
MIS45_05085	COG1086	Polysaccharide biosynthesis protein
MIS45_05090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MIS45_05115	COG0714	Associated with various cellular activities
MIS45_05125	COG2070	2-Nitropropane dioxygenase
MIS45_05145	COG1113	amino acid transport
MIS45_05160	COG1561	YicC-like family, N-terminal region
MIS45_05175	COG0508	dehydrogenase complex catalyzes the overall conversion of
MIS45_05180	COG3042	response to heat
MIS45_05185	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MIS45_05205	COG0756	dUTP diphosphatase activity
MIS45_05235	COG1530	ribonuclease E activity
MIS45_05265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIS45_05275	COG0105	UTP biosynthetic process
MIS45_05280	COG1562	ergosterol biosynthetic process
MIS45_05285	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MIS45_05290	COG1028	Short-chain dehydrogenase reductase Sdr
MIS45_05320	COG1476	TRANSCRIPTIONal
MIS45_05405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MIS45_05425	COG0163	prenyltransferase activity
MIS45_05435	COG0489	protein tyrosine kinase activity
MIS45_05450	COG3045	CreA protein
MIS45_05455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MIS45_05460	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MIS45_05465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MIS45_05475	COG1862	Preprotein translocase
MIS45_05480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MIS45_05485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MIS45_05490	COG0492	ferredoxin-NADP+ reductase activity
MIS45_05515	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MIS45_05525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MIS45_05530	COG1083	cytidylyl-transferase
MIS45_05535	COG4783	chaperone-mediated protein folding
MIS45_05560	COG2431	L-lysine efflux transmembrane transporter activity
MIS45_05565	COG1214	PFAM Peptidase M22, glycoprotease
MIS45_05600	COG0586	Pfam SNARE associated Golgi protein
MIS45_05630	COG1085	galactose-1-phosphate uridylyltransferase
MIS45_05635	COG1879	ABC-type sugar transport system periplasmic component
MIS45_05640	COG1129	ABC transporter
MIS45_05645	COG4211	Belongs to the binding-protein-dependent transport system permease family
MIS45_05695	COG0633	Ferredoxin
MIS45_05700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MIS45_05705	COG2195	Cleaves the N-terminal amino acid of tripeptides
MIS45_05715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MIS45_05725	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MIS45_05730	COG1794	racemase activity, acting on amino acids and derivatives
MIS45_05735	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MIS45_05755	COG1307	EDD domain protein, DegV family
MIS45_05765	COG1115	amino acid carrier protein
MIS45_05780	COG1199	ATP-dependent helicase activity
MIS45_05790	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MIS45_05800	COG0442	prolyl-tRNA aminoacylation
MIS45_05825	COG0805	protein transport
MIS45_05860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MIS45_05870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MIS45_05875	COG1970	mechanosensitive ion channel activity
MIS45_05890	COG0512	Glutamine amidotransferase of anthranilate synthase
MIS45_05900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MIS45_05955	COG1442	glycosyl transferase family 8
MIS45_05970	COG0488	(ABC) transporter
MIS45_05980	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MIS45_06050	COG1217	gtp-binding protein TYPA
MIS45_06110	COG0347	Belongs to the P(II) protein family
MIS45_06125	COG0802	atpase or kinase
MIS45_06135	COG2501	S4 domain
MIS45_06145	COG2999	glutathione oxidoreductase activity
MIS45_06150	COG0741	lytic transglycosylase activity
MIS45_06210	COG4783	chaperone-mediated protein folding
MIS45_06220	COG2839	Protein conserved in bacteria
MIS45_06225	COG0613	PHP domain protein
MIS45_06250	COG1959	2 iron, 2 sulfur cluster binding
MIS45_06270	COG2959	enzyme of heme biosynthesis
MIS45_06280	COG1187	pseudouridine synthase activity
MIS45_06290	COG0440	acetolactate synthase activity
MIS45_06295	COG0028	Belongs to the TPP enzyme family
MIS45_06305	COG4969	Belongs to the N-Me-Phe pilin family
MIS45_06315	COG1333	cytochrome c biogenesis protein
MIS45_06340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MIS45_06385	COG0307	riboflavin synthase, alpha
MIS45_06390	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MIS45_06395	COG1131	(ABC) transporter
MIS45_06405	COG1522	sequence-specific DNA binding
MIS45_06415	COG0708	Exodeoxyribonuclease III
MIS45_06450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MIS45_06455	COG0579	oxidoreductase
MIS45_06460	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MIS45_06470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MIS45_06485	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MIS45_06495	COG0488	(ABC) transporter
MIS45_06540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MIS45_06555	COG0488	(ABC) transporter
MIS45_06600	COG3676	manually curated
MIS45_06605	COG0859	PFAM glycosyl transferase family 9
MIS45_06615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MIS45_06630	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
MIS45_06645	COG0488	(ABC) transporter
MIS45_06665	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MIS45_06670	COG1496	oxidoreductase activity
MIS45_06695	COG0497	DNA recombination
MIS45_06730	COG3038	cytochrome b561
MIS45_06735	COG0688	phosphatidylethanolamine metabolic process
MIS45_06760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MIS45_06775	COG0557	exoribonuclease II activity
MIS45_06795	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MIS45_06800	COG1216	Glycosyl transferase, family 2
MIS45_06800	COG1442	glycosyl transferase family 8
MIS45_06815	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MIS45_06835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MIS45_06840	COG1136	(ABC) transporter
MIS45_06840	COG0577	efflux transmembrane transporter activity
MIS45_06845	COG1538	Outer membrane efflux protein
MIS45_06855	COG1178	ABC-type Fe3 transport system permease component
MIS45_06870	COG1733	regulation of RNA biosynthetic process
MIS45_06875	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MIS45_06885	COG0446	pyridine nucleotide-disulphide oxidoreductase
MIS45_06885	COG1902	pentaerythritol trinitrate reductase activity
MIS45_06890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MIS45_06940	COG0560	Phosphoserine phosphatase
MIS45_06945	COG1074	ATP-dependent DNA helicase activity
MIS45_06965	COG1045	serine acetyltransferase
MIS45_07000	COG0494	nUDIX hydrolase
MIS45_07005	COG3264	Mechanosensitive ion channel
MIS45_07005	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MIS45_07025	COG0633	Ferredoxin
MIS45_07055	COG2814	Major facilitator Superfamily
MIS45_07065	COG0575	Belongs to the CDS family
MIS45_07070	COG0252	asparaginase activity
MIS45_07080	COG1247	-acetyltransferase
MIS45_07095	COG3094	Invasion gene expression up-regulator, SirB
MIS45_07105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MIS45_07120	COG0513	Belongs to the DEAD box helicase family
MIS45_07125	COG3700	Belongs to the class B bacterial acid phosphatase family
MIS45_07135	COG0295	cytidine deaminase activity
MIS45_07140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MIS45_07145	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MIS45_07155	COG0813	purine-nucleoside phosphorylase activity
MIS45_07180	COG0531	amino acid
MIS45_07185	COG0457	Tetratricopeptide repeat
MIS45_07185	COG0705	Rhomboid family
MIS45_07195	COG0121	glutamine amidotransferase
MIS45_07220	COG1476	TRANSCRIPTIONal
MIS45_07230	COG4735	regulation of single-species biofilm formation
MIS45_07260	COG1393	Belongs to the ArsC family
MIS45_07275	COG0433	COG0433 Predicted ATPase
MIS45_07285	COG0312	modulator of DNA gyrase
MIS45_07305	COG0281	malic enzyme
MIS45_07305	COG0280	phosphate acetyltransferase
MIS45_07375	COG3008	intermembrane lipid transfer
MIS45_07375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MIS45_07445	COG1077	Cell shape determining protein MreB Mrl
MIS45_07455	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MIS45_07460	COG0768	penicillin binding
MIS45_07465	COG0772	Belongs to the SEDS family
MIS45_07470	COG2095	MarC family integral membrane protein
MIS45_07560	COG0738	Major facilitator superfamily
MIS45_07570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MIS45_07585	COG1760	l-serine dehydratase
MIS45_07590	COG1196	nuclear chromosome segregation
MIS45_07595	COG2610	gluconate transmembrane transporter activity
MIS45_07600	COG3265	gluconokinase activity
MIS45_07630	COG3307	-O-antigen
MIS45_07640	COG0739	heme binding
MIS45_07715	COG1114	Component of the transport system for branched-chain amino acids
MIS45_07745	COG1505	serine-type exopeptidase activity
MIS45_07780	COG4977	sequence-specific DNA binding
MIS45_07790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MIS45_07810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MIS45_07815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MIS45_07845	COG1064	alcohol dehydrogenase
MIS45_07850	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MIS45_07855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MIS45_07880	COG1373	ATPase (AAA superfamily
MIS45_07900	COG2249	NAD(P)H dehydrogenase (quinone) activity
MIS45_07920	COG0583	DNA-binding transcription factor activity
MIS45_07925	COG1902	pentaerythritol trinitrate reductase activity
MIS45_07940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MIS45_07970	COG0778	Nitroreductase
MIS45_07990	COG1902	pentaerythritol trinitrate reductase activity
MIS45_08015	COG1902	pentaerythritol trinitrate reductase activity
MIS45_08020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MIS45_08040	COG1733	regulation of RNA biosynthetic process
MIS45_08045	COG0519	Catalyzes the synthesis of GMP from XMP
MIS45_08080	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MIS45_08090	COG0456	acetyltransferase
MIS45_08150	COG1442	glycosyl transferase family 8
MIS45_08150	COG1216	Glycosyl transferase, family 2
MIS45_08155	COG1575	Belongs to the MenA family. Type 1 subfamily
MIS45_08170	COG1216	Glycosyl transferase, family 2
MIS45_08175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MIS45_08200	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MIS45_08220	COG1137	ATPase activity
MIS45_08225	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MIS45_08230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MIS45_08240	COG1192	Involved in chromosome partitioning
MIS45_08300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MIS45_08315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MIS45_08410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MIS45_08425	COG0859	PFAM glycosyl transferase family 9
MIS45_08430	COG2814	Major facilitator Superfamily
MIS45_08440	COG0501	Belongs to the peptidase M48B family
MIS45_08475	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MIS45_08515	COG2223	nitrite transmembrane transporter activity
MIS45_08525	COG2205	protein histidine kinase activity
MIS45_08530	COG0745	RESPONSE REGULATOR receiver
MIS45_08535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MIS45_08540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MIS45_08545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MIS45_08545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MIS45_08560	COG0814	amino acid
MIS45_08565	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MIS45_08580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MIS45_08585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MIS45_08590	COG0012	GTP binding
MIS45_08600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MIS45_08615	COG2975	iron-sulfur cluster assembly
MIS45_08635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MIS45_08635	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MIS45_08665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MIS45_08680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MIS45_08685	COG0678	peroxiredoxin activity
MIS45_08685	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MIS45_08700	COG1278	Cold shock
MIS45_08710	COG0542	response to heat
MIS45_08720	COG0009	L-threonylcarbamoyladenylate synthase
MIS45_08730	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MIS45_08735	COG0237	dephospho-CoA kinase activity
MIS45_08760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MIS45_08765	COG2833	Protein of unknown function (DUF455)
MIS45_08790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MIS45_08795	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MIS45_08830	COG1126	abc transporter atp-binding protein
MIS45_08835	COG0765	amino acid transport
MIS45_08840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIS45_08850	COG0778	Nitroreductase
MIS45_08855	COG0546	phosphoglycolate phosphatase activity
MIS45_08875	COG0435	Glutathione S-transferase
MIS45_08955	COG0277	FAD linked oxidase domain protein
MIS45_08965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MIS45_08990	COG0527	aspartate kinase activity
MIS45_08995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MIS45_09000	COG0583	DNA-binding transcription factor activity
MIS45_09130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MIS45_09145	COG1530	ribonuclease E activity
MIS45_09205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MIS45_09210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIS45_09225	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
MIS45_09255	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MIS45_09265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MIS45_09270	COG0583	DNA-binding transcription factor activity
MIS45_09275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIS45_09300	COG0583	DNA-binding transcription factor activity
MIS45_09310	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MIS45_09315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MIS45_09320	COG1984	allophanate hydrolase subunit 2
MIS45_09335	COG1914	H( )-stimulated, divalent metal cation uptake system
MIS45_09420	COG2056	Na+-H+ antiporter family
MIS45_09480	COG2251	uridine kinase activity
MIS45_09480	COG0195	Participates in both transcription termination and antitermination
MIS45_09520	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MIS45_09570	COG1564	THIamine pyrophosphokinase
MIS45_09595	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MIS45_09605	COG1183	phosphatidylcholine synthase activity
MIS45_09640	COG2217	Heavy metal translocating P-type atpase
MIS45_09645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MIS45_09650	COG0477	Major facilitator Superfamily
MIS45_09665	COG0697	spore germination
MIS45_09785	COG0477	Major facilitator Superfamily
MIS45_09790	COG2233	PERMEase
MIS45_09795	COG1765	OsmC-like protein
MIS45_09805	COG0330	HflC and HflK could
MIS45_09810	COG0625	glutathione transferase activity
MIS45_09815	COG2969	positive regulation of protein catabolic process
MIS45_09850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MIS45_09870	COG2837	iron assimilation
MIS45_09875	COG0204	Acyl-transferase
MIS45_09895	COG1120	ATPase activity
MIS45_09905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MIS45_09990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MIS45_10000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MIS45_10005	COG0287	Prephenate dehydrogenase
MIS45_10015	COG1846	Transcriptional regulator
MIS45_10020	COG0765	amino acid transport
MIS45_10025	COG0196	riboflavin kinase activity
MIS45_10030	COG4604	ABC transporter, ATP-binding protein
MIS45_10040	COG4605	iron ion homeostasis
MIS45_10050	COG1373	ATPase (AAA superfamily
MIS45_10060	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MIS45_10095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MIS45_10095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MIS45_10110	COG0424	maF-like protein
MIS45_10115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MIS45_10120	COG0799	negative regulation of ribosome biogenesis
MIS45_10150	COG2951	lytic endotransglycosylase activity
MIS45_10155	COG3012	SEC-C Motif Domain Protein
MIS45_10160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MIS45_10190	COG3909	cytochrome
MIS45_10195	COG4221	oxidoreductase activity
MIS45_10205	COG4682	membrane
MIS45_10210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MIS45_10225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MIS45_10230	COG2011	ABC-type metal ion transport system permease component
MIS45_10235	COG1464	Belongs to the NlpA lipoprotein family
MIS45_10250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MIS45_10255	COG0561	phosphatase activity
MIS45_10280	COG0210	DNA helicase
MIS45_10285	COG2906	2 iron, 2 sulfur cluster binding
MIS45_10305	COG0586	Pfam SNARE associated Golgi protein
MIS45_10310	COG0612	Peptidase, M16
MIS45_10325	COG0753	catalase activity
MIS45_10330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MIS45_10365	COG0616	signal peptide processing
MIS45_10365	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MIS45_10375	COG1793	dna ligase
MIS45_10380	COG0583	DNA-binding transcription factor activity
MIS45_10400	COG4804	nuclease activity
MIS45_10425	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
MIS45_10460	COG2364	Membrane
MIS45_10490	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MIS45_10495	COG2866	Carboxypeptidase
MIS45_10500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MIS45_10505	COG1064	alcohol dehydrogenase
MIS45_10555	COG0542	response to heat
MIS45_10565	COG3977	Valine--pyruvate aminotransferase
MIS45_10585	COG0277	FAD linked oxidase domain protein
MIS45_10590	COG0791	NLP P60 protein
MIS45_10610	COG0288	reversible hydration of carbon dioxide
MIS45_10615	COG0803	Belongs to the bacterial solute-binding protein 9 family
MIS45_10620	COG0842	Transport permease protein
MIS45_10620	COG1129	ABC transporter
MIS45_10625	COG0842	Transport permease protein
MIS45_10635	COG1555	photosystem II stabilization
MIS45_10635	COG1596	polysaccharide export
MIS45_10650	COG2252	PERMEase
MIS45_10655	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MIS45_10690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MIS45_10700	COG2271	Major facilitator Superfamily
MIS45_10730	COG0519	Catalyzes the synthesis of GMP from XMP
MIS45_10730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MIS45_10735	COG1115	amino acid carrier protein
MIS45_10750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MIS45_10755	COG0469	pyruvate kinase activity
MIS45_10765	COG3842	ATPase activity
MIS45_10780	COG0346	lactoylglutathione lyase activity
MIS45_10785	COG0671	phosphoesterase, PA-phosphatase related
MIS45_10785	COG2453	phosphatase
MIS45_10790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MIS45_10800	COG1610	YqeY-like protein
MIS45_10830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MIS45_10835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MIS45_10845	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MIS45_10865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MIS45_10870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MIS45_10885	COG1297	OPT oligopeptide transporter protein
MIS45_10890	COG3738	Protein conserved in bacteria
MIS45_10940	COG1739	Uncharacterized protein family UPF0029
MIS45_10965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MIS45_10985	COG3423	Transcriptional regulator
MIS45_11040	COG4396	Host-nuclease inhibitor protein Gam
MIS45_11055	COG0776	regulation of translation
MIS45_11060	COG4382	Mu-like prophage protein Gp16
MIS45_11140	COG2369	cell adhesion
MIS45_11260	COG3392	D12 class N6 adenine-specific DNA methyltransferase