locus-tag class description COG0445 tRNA wobble uridine modification COG0356 it plays a direct role in the translocation of protons across the membrane COG0449 glutamine-fructose-6-phosphate transaminase (isomerizing) activity COG1136 (ABC) transporter COG4591 ABC-type transport system involved in lipoprotein release permease component COG0015 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily COG0482 sulfurtransferase activity COG0501 Belongs to the peptidase M48B family COG1253 flavin adenine dinucleotide binding COG0616 signal peptide processing COG0057 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity COG0576 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0061 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP COG0486 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 COG2867 negative regulation of translational initiation COG0691 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene COG0173 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) COG0817 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group COG1108 ABC-type Mn2 Zn2 transport systems permease components COG1121 (ABC) transporter COG0739 heme binding COG1914 H( )-stimulated, divalent metal cation uptake system COG2226 methyltransferase COG0706 membrane insertase activity COG0661 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis COG0043 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity COG4635 menaquinone-dependent protoporphyrinogen oxidase activity COG0230 Belongs to the bacterial ribosomal protein bL34 family COG1448 Aminotransferase COG0491 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid COG0008 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) COG0382 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate COG0018 arginyl-trna synthetase COG0167 dihydroorotate dehydrogenase activity COG0113 porphobilinogen synthase activity COG0796 Provides the (R)-glutamate required for cell wall biosynthesis COG1502 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol COG0306 phosphate transporter COG0469 pyruvate kinase activity COG0590 tRNA wobble adenosine to inosine editing COG0103 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) COG0102 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly COG0187 DNA topoisomerase II activity COG1485 Reduces the stability of FtsZ polymers in the presence of ATP COG3105 Protein conserved in bacteria COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain COG1154 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) COG0142 geranyltranstransferase activity COG1893 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid COG1622 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor COG0843 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B COG1845 cytochrome c oxidase, subunit III COG3125 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor COG0109 protoheme IX farnesyltransferase activity COG0760 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation COG0466 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner COG1219 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP COG0740 serine-type endopeptidase activity COG0544 peptidyl-prolyl cis-trans isomerase activity COG2814 Major facilitator Superfamily COG0379 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate COG0463 Glycosyl transferase, family 2 COG0223 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus COG0451 ADP-glyceromanno-heptose 6-epimerase activity COG0760 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation COG0726 polysaccharide deacetylase COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family COG0816 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA COG1678 Uncharacterized ACR, COG1678 COG0189 ligase activity COG1385 rRNA (uridine-N3-)-methyltransferase activity COG0495 leucyl-tRNA aminoacylation COG1466 dna polymerase III delta subunit COG1995 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) COG1057 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) COG0768 penicillin binding COG0772 Belongs to the SEDS family COG1686 Belongs to the peptidase S11 family COG0321 lipoyl(octanoyl) transferase activity COG0320 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives COG0566 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family COG0104 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP COG0280 phosphate acetyltransferase COG0857 belongs to the CobB CobQ family COG0030 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity COG0282 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction COG0415 Belongs to the DNA photolyase family COG0324 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) COG1923 regulation of RNA biosynthetic process COG0330 HflC and HflK could COG0330 HflC and HflK could COG2814 Major facilitator Superfamily COG0765 amino acid transport COG0765 amino acid transport COG0639 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain COG0237 dephospho-CoA kinase activity COG0481 GTPase activity COG0571 ribonuclease III activity COG0854 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate COG0736 holo-[acyl-carrier-protein] synthase activity COG1191 sigma factor activity COG0653 protein targeting COG0262 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis COG0774 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity COG0206 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity COG0849 cell division COG0773 UDP-N-acetylmuramate-L-alanine ligase activity COG0707 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) COG0772 Belongs to the SEDS family COG0771 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) COG0472 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan COG0770 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity COG0458 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity COG0769 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan COG0768 penicillin binding COG3116 cell division COG0275 rRNA processing COG1528 Iron-storage protein COG1181 Belongs to the D-alanine--D-alanine ligase family COG0588 phosphoglycerate mutase activity COG1132 (ABC) transporter COG1132 (ABC) transporter COG0505 Belongs to the CarA family COG0513 Belongs to the DEAD box helicase family COG1185 polyribonucleotide nucleotidyltransferase activity COG0184 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome COG0130 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs COG0858 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA COG0532 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex COG0195 Participates in both transcription termination and antitermination COG1314 P-P-bond-hydrolysis-driven protein transmembrane transporter activity COG0289 4-hydroxy-tetrahydrodipicolinate reductase COG1109 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate COG0294 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives COG0782 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus COG0013 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain COG0468 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage COG0722 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) COG0628 permease COG0108 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate COG0617 tRNA 3'-terminal CCA addition COG0361 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex COG0190 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate COG0215 cysteine-tRNA ligase activity COG2908 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell COG0041 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) COG0048 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit COG0026 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) COG2918 glutathione biosynthetic process COG0541 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0228 four-way junction DNA binding COG0335 large ribosomal subunit rRNA binding COG1212 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria COG2835 tetraacyldisaccharide 4'-kinase activity COG1663 tetraacyldisaccharide 4'-kinase activity COG1132 (ABC) transporter COG1862 Preprotein translocase COG0049 tRNA binding COG0258 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity COG1651 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process COG0459 protein refolding COG0234 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter COG0359 binds to the 23S rRNA COG0238 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit COG0360 Binds together with S18 to 16S ribosomal RNA COG0017 Asparaginyl-tRNA synthetase COG0801 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG1330 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity COG0480 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome COG1074 ATP-dependent DNA helicase activity COG0253 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan COG1011 Hydrolase COG0210 DNA helicase COG0598 Magnesium transport protein CorA COG0149 triose-phosphate isomerase activity COG1018 Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress COG2814 Major facilitator Superfamily COG1220 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis COG5405 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery COG0254 rRNA binding COG1131 (ABC) transporter COG0842 Transport permease protein COG0624 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls COG0692 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine COG0483 inositol monophosphate 1-phosphatase activity COG0711 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) COG0231 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase COG0008 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) COG0669 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate COG1519 Transferase COG0027 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate COG0761 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis COG0597 This protein specifically catalyzes the removal of signal peptides from prolipoproteins COG0060 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) COG0196 riboflavin kinase activity COG0268 Binds directly to 16S ribosomal RNA COG3004 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons COG0484 heat shock protein binding COG0443 Heat shock 70 kDa protein COG0764 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity COG0694 Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins COG0399 UDP-4-amino-4-deoxy-L-arabinose aminotransferase COG1158 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template COG3118 belongs to the thioredoxin family COG0126 phosphoglycerate kinase activity COG0191 fructose-bisphosphate aldolase activity COG0496 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates COG0111 D-isomer specific 2-hydroxyacid dehydrogenase COG0101 tRNA pseudouridine synthase activity COG0777 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA COG0285 dihydrofolate synthase activity COG0034 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine COG0558 Belongs to the CDP-alcohol phosphatidyltransferase class-I family COG0192 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme COG0302 gtp cyclohydrolase COG0351 phosphomethylpyrimidine kinase COG0682 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins COG1298 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin COG0207 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis COG1249 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family COG0508 dehydrogenase complex catalyzes the overall conversion of COG2609 component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) COG0157 Belongs to the NadC ModD family COG3117 lipopolysaccharide transmembrane transporter activity COG1137 ATPase activity COG5007 Belongs to the BolA IbaG family COG0766 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine COG0152 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity COG0329 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) COG0150 phosphoribosylformylglycinamidine cyclo-ligase activity COG0307 riboflavin synthase, alpha COG0278 Belongs to the glutaredoxin family. Monothiol subfamily COG0847 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease COG1846 Transcriptional regulator COG0259 pyridoxamine-phosphate oxidase activity COG0162 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) COG0177 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate COG0114 fumarate hydratase activity COG2877 3-deoxy-8-phosphooctulonate synthase activity COG0216 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA COG0373 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) COG3017 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein COG1947 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol COG1815 bacterial-type flagellum-dependent cell motility COG0462 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) COG0193 aminoacyl-tRNA hydrolase activity COG0012 GTP binding COG1376 ErfK ybiS ycfS ynhG family protein COG0148 phosphopyruvate hydratase activity COG0504 CTP synthase activity COG2166 iron-sulfur cluster assembly COG0520 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine COG0719 Fe-S assembly protein COG1558 bacterial-type flagellum-dependent cell motility COG0396 ATPase activity COG0719 Fe-S assembly protein COG0316 Belongs to the HesB IscA family COG0623 enoyl-[acyl-carrier-protein] reductase (NADH) activity COG0284 orotidine-5'-phosphate decarboxylase activity COG0807 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate COG1502 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol COG2916 Histone family protein nucleoid-structuring protein H-NS COG1843 Required for flagellar hook formation. May act as a scaffolding protein COG1210 Utp--glucose-1-phosphate uridylyltransferase COG0788 formyltetrahydrofolate deformylase activity COG0851 Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell COG2894 cell division COG0850 regulation of cytokinetic process COG0787 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids COG3263 regulation of cellular component size COG0825 malonyl-CoA metabolic process COG0712 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation COG1749 Flagellar hook protein flgE COG0763 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell COG1043 involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell COG1044 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell COG2825 PFAM Outer membrane chaperone Skp (OmpH) COG4775 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane COG0750 zinc metalloprotease COG0575 Belongs to the CDS family COG0020 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids COG0743 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity COG4787 bacterial-type flagellum-dependent cell motility COG0233 cytoplasmic translational termination COG0264 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome COG0052 Belongs to the universal ribosomal protein uS2 family COG0024 Methionine aminopeptidase COG2171 N-acyltransferase activity COG0037 tRNA processing COG0461 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) COG0756 dUTP diphosphatase activity COG0452 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine COG0227 Belongs to the bacterial ribosomal protein bL28 family COG0267 Belongs to the bacterial ribosomal protein bL33 family COG1758 RNA polymerase activity COG0194 GDP metabolic process COG1846 Transcriptional regulator COG2063 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation COG0304 beta-ketoacyl-acyl-carrier-protein synthase II activity COG2890 protein-(glutamine-N5) methyltransferase activity COG2885 chlorophyll binding COG0823 Involved in the tonB-independent uptake of proteins COG0848 biopolymer transport protein COG0811 peptide transport COG0074 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit COG1706 bacterial-type flagellum-dependent cell motility COG0045 succinate-CoA ligase (ADP-forming) activity COG0508 dehydrogenase complex catalyzes the overall conversion of COG0567 Dehydrogenase, E1 component COG1053 succinate dehydrogenase COG2142 Succinate dehydrogenase hydrophobic membrane anchor COG0327 Belongs to the GTP cyclohydrolase I type 2 NIF3 family COG0033 Phosphoglucomutase COG0716 FMN binding COG1511 domain protein COG3264 Mechanosensitive ion channel COG0688 phosphatidylethanolamine metabolic process COG1949 3'-to-5' exoribonuclease specific for small oligoribonucleotides COG0586 Pfam SNARE associated Golgi protein COG0654 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases COG0006 proline dipeptidase activity COG3027 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division COG0506 proline dehydrogenase activity COG3905 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source COG4230 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source COG0272 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA COG0354 folic acid binding COG2938 An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH COG0608 single-stranded DNA 5'-3' exodeoxyribonuclease activity COG1190 Belongs to the class-II aminoacyl-tRNA synthetase family COG2095 MarC family integral membrane protein COG0136 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate COG2227 3-demethylubiquinone-9 3-O-methyltransferase activity COG0815 Transfers the fatty acyl group on membrane lipoproteins COG0319 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA COG0414 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate COG0413 3-methyl-2-oxobutanoate hydroxymethyltransferase activity COG0313 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA COG2823 Periplasmic or secreted lipoprotein COG0161 adenosylmethionine-8-amino-7-oxononanoate transaminase activity COG0502 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism COG2226 methyltransferase COG0132 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring COG0795 lipopolysaccharide-transporting ATPase activity COG0795 lipopolysaccharide-transporting ATPase activity COG0260 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides COG0525 valine-tRNA ligase activity COG0540 Belongs to the ATCase OTCase family COG0117 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate COG1985 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate COG0054 6,7-dimethyl-8-ribityllumazine synthase activity COG0781 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons COG0611 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 COG1338 Plays a role in the flagellum-specific transport system COG1267 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) COG0358 DNA primase activity COG0828 Belongs to the bacterial ribosomal protein bS21 family COG0533 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction COG1539 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin COG1968 undecaprenyl-diphosphatase activity COG0654 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases COG0056 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit COG1338 Plays a role in the flagellum-specific transport system COG3190 flagellar COG0536 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0211 Belongs to the bacterial ribosomal protein bL27 family COG0261 This protein binds to 23S rRNA in the presence of protein L20 COG0142 geranyltranstransferase activity COG0158 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 COG0221 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions COG2911 Protein conserved in bacteria COG0729 surface antigen COG0539 negative regulation of cytoplasmic translation COG0283 belongs to the cytidylate kinase family. Type 1 subfamily COG1932 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine COG0450 alkyl hydroperoxide reductase COG0172 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) COG2834 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) COG0492 ferredoxin-NADP+ reductase activity COG0814 amino acid COG0223 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus COG0242 peptide deformylase activity COG0009 L-threonylcarbamoyladenylate synthase COG0629 single-stranded DNA binding COG0112 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism COG0120 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate COG3785 DNA binding COG1580 Controls the rotational direction of flagella during chemotaxis COG2022 thiamine diphosphate biosynthetic process COG0422 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction COG0407 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III COG0151 Belongs to the GarS family COG0138 bifunctional purine biosynthesis protein purh COG0812 UDP-N-acetylmuramate dehydrogenase activity COG0340 biotin-[acetyl-CoA-carboxylase] ligase activity COG1654 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon COG1072 (Pantothenic acid kinase)) COG3144 bacterial-type flagellum assembly COG0050 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis COG0690 P-P-bond-hydrolysis-driven protein transmembrane transporter activity COG0250 Participates in transcription elongation, termination and antitermination COG0080 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors COG0081 regulation of translation COG0244 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors COG0222 ribosome binding COG0085 RNA polymerase activity COG0086 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates COG2812 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity COG0718 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection COG0326 Molecular chaperone. Has ATPase activity COG0563 adenylate kinase activity COG0276 Catalyzes the ferrous insertion into protoporphyrin IX COG0670 Belongs to the BI1 family COG0245 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity COG1211 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity COG4105 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane COG0564 pseudouridine synthase activity COG0143 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation COG0717 Belongs to the dCTP deaminase family COG0745 RESPONSE REGULATOR receiver COG0240 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity COG0695 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins COG0607 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS COG0051 transcription antitermination factor activity, RNA binding COG0087 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit COG0088 Forms part of the polypeptide exit tunnel COG0089 rRNA binding COG0090 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0185 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA COG0091 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome COG0092 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation COG1536 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation COG0197 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs COG0255 Belongs to the universal ribosomal protein uL29 family COG0186 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA COG0093 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome COG0198 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit COG0094 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0199 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site COG0096 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit COG0097 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center COG0256 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance COG1766 The M ring may be actively involved in energy transduction COG0098 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body COG1841 ribosomal large subunit assembly COG0200 Binds to the 23S rRNA COG0201 protein transport COG0257 Belongs to the bacterial ribosomal protein bL36 family COG0099 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0100 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome COG0522 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit COG0202 RNA polymerase activity COG0203 ribosomal protein L17 COG0224 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex COG1677 Flagellar hook-basal body complex protein FliE COG0105 UTP biosynthetic process COG0820 rRNA (adenine-C2-)-methyltransferase activity COG1426 Protein conserved in bacteria COG0821 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate COG0124 histidyl-tRNA synthetase COG2976 Protein conserved in bacteria COG1866 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA COG0703 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate COG0036 Belongs to the ribulose-phosphate 3-epimerase family COG0180 Tryptophanyl-tRNA synthetase COG0021 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate COG0176 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway COG0408 coproporphyrinogen oxidase activity COG0596 Alpha beta hydrolase COG0367 asparagine synthase COG1988 membrane-bound metal-dependent COG0174 glutamine synthetase COG1781 'de novo' pyrimidine nucleobase biosynthetic process COG0460 homoserine dehydrogenase COG0527 aspartate kinase activity COG0752 glycyl-tRNA synthetase alpha subunit COG0751 glycine-tRNA ligase activity COG0605 Destroys radicals which are normally produced within the cells and which are toxic to biological systems COG0744 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors COG0442 prolyl-tRNA aminoacylation COG0166 Belongs to the GPI family COG2891 Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins COG1792 Involved in formation and maintenance of cell shape COG1077 Cell shape determining protein MreB Mrl COG0511 ligase activity, forming carbon-carbon bonds COG0439 Biotin carboxylase COG1054 Belongs to the UPF0176 family COG0579 oxidoreductase COG0516 GMP reductase activity COG0517 IMP dehydrogenase activity COG0519 Catalyzes the synthesis of GMP from XMP COG1561 YicC-like family, N-terminal region COG3158 transport of potassium into the cell COG0209 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides COG2943 transferase activity, transferring hexosyl groups COG1780 Probably involved in ribonucleotide reductase function COG0491 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid COG0328 RNA-DNA hybrid ribonuclease activity COG0847 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease COG0742 ribosomal rna small subunit methyltransferase COG0055 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits COG0552 protein localization to endoplasmic reticulum COG0001 glutamate-1-semialdehyde 2,1-aminomutase activity COG0316 Belongs to the HesB IscA family COG0741 lytic transglycosylase activity COG2924 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes COG0635 Involved in the biosynthesis of porphyrin-containing compound COG0127 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions COG0345 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline COG0325 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis COG0355 proton-transporting ATP synthase activity, rotational mechanism COG0441 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) COG0290 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins COG0291 Belongs to the bacterial ribosomal protein bL35 family COG0292 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit COG0016 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily COG0072 phenylalanine-tRNA ligase activity COG0418 dihydroorotase activity COG1530 ribonuclease E activity COG0333 Belongs to the bacterial ribosomal protein bL32 family COG0331 [acyl-carrier-protein] S-malonyltransferase activity COG1207 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain COG1028 Short-chain dehydrogenase reductase Sdr COG0236 Carrier of the growing fatty acid chain in fatty acid biosynthesis COG1559 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation COG0125 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis COG0470 DNA polymerase III COG0084 hydrolase, TatD family' COG0537 adenosine 5'-monophosphoramidase activity COG1252 NADH dehydrogenase COG1197 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site COG4591 ABC-type transport system involved in lipoprotein release permease component