locus-tag	class	description
H0I32_00035	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H0I32_00045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0I32_00055	COG0492	ferredoxin-NADP+ reductase activity
H0I32_00065	COG0069	glutamate synthase activity
H0I32_00095	COG4251	negative regulation of phosphorylation
H0I32_00105	COG1733	regulation of RNA biosynthetic process
H0I32_00110	COG0778	Nitroreductase
H0I32_00140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0I32_00165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H0I32_00165	COG0784	Response regulator, receiver
H0I32_00170	COG2807	transmembrane transport
H0I32_00185	COG1012	belongs to the aldehyde dehydrogenase family
H0I32_00190	COG1278	Cold shock
H0I32_00205	COG1028	Short-chain dehydrogenase reductase Sdr
H0I32_00210	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H0I32_00220	COG4942	peptidase
H0I32_00235	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H0I32_00240	COG1278	Cold shock
H0I32_00255	COG2814	Major facilitator Superfamily
H0I32_00260	COG0668	transmembrane transport
H0I32_00290	COG0668	transmembrane transport
H0I32_00300	COG0101	tRNA pseudouridine synthase activity
H0I32_00305	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0I32_00305	COG0140	phosphoribosyl-ATP diphosphatase activity
H0I32_00310	COG0107	imidazoleglycerol-phosphate synthase activity
H0I32_00315	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H0I32_00325	COG0131	Imidazoleglycerol-phosphate dehydratase
H0I32_00325	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H0I32_00330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0I32_00335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0I32_00340	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0I32_00355	COG1028	Short-chain dehydrogenase reductase Sdr
H0I32_00360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H0I32_00365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0I32_00370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0I32_00375	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0I32_00380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0I32_00380	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H0I32_00385	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0I32_00390	COG1078	dGTPase activity
H0I32_00395	COG2204	response regulator
H0I32_00400	COG0802	atpase or kinase
H0I32_00425	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H0I32_00430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0I32_00440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H0I32_00450	COG1522	sequence-specific DNA binding
H0I32_00500	COG0012	GTP binding
H0I32_00505	COG4251	negative regulation of phosphorylation
H0I32_00510	COG0784	Response regulator, receiver
H0I32_00550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0I32_00560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H0I32_00565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0I32_00620	COG1228	amidohydrolase
H0I32_00630	COG0010	Belongs to the arginase family
H0I32_00635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I32_00675	COG3279	Response regulator of the LytR AlgR family
H0I32_00695	COG3275	phosphorelay sensor kinase activity
H0I32_00735	COG1404	Belongs to the peptidase S8 family
H0I32_00735	COG4935	Belongs to the peptidase S8 family
H0I32_00745	COG3118	belongs to the thioredoxin family
H0I32_00780	COG0577	efflux transmembrane transporter activity
H0I32_00780	COG1136	(ABC) transporter
H0I32_00785	COG1136	(ABC) transporter
H0I32_00790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0I32_00800	COG1703	isobutyryl-CoA mutase activity
H0I32_00810	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0I32_00810	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0I32_00815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0I32_00820	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H0I32_00825	COG0511	ligase activity, forming carbon-carbon bonds
H0I32_00835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0I32_00840	COG0346	lactoylglutathione lyase activity
H0I32_00845	COG0095	Lipoate-protein ligase
H0I32_00850	COG1272	protein, Hemolysin III
H0I32_00865	COG1131	(ABC) transporter
H0I32_00870	COG1363	Peptidase, m42
H0I32_00895	COG2339	peptidase activity
H0I32_00905	COG0439	Biotin carboxylase
H0I32_00910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0I32_00915	COG1132	(ABC) transporter
H0I32_00920	COG2814	Major facilitator Superfamily
H0I32_00925	COG0009	L-threonylcarbamoyladenylate synthase
H0I32_00945	COG3279	Response regulator of the LytR AlgR family
H0I32_00950	COG3275	phosphorelay sensor kinase activity
H0I32_00980	COG0438	transferase activity, transferring glycosyl groups
H0I32_00985	COG1472	Belongs to the glycosyl hydrolase 3 family
H0I32_00990	COG0560	Phosphoserine phosphatase
H0I32_00990	COG3830	Belongs to the UPF0237 family
H0I32_01015	COG0247	lactate metabolic process
H0I32_01015	COG2181	nitrate reductase activity
H0I32_01025	COG0247	lactate metabolic process
H0I32_01025	COG2181	nitrate reductase activity
H0I32_01030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H0I32_01035	COG0860	N-Acetylmuramoyl-L-alanine amidase
H0I32_01045	COG0251	oxidation-reduction process
H0I32_01065	COG4251	negative regulation of phosphorylation
H0I32_01075	COG0463	Glycosyl transferase, family 2
H0I32_01115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0I32_01120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0I32_01140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0I32_01190	COG0156	8-amino-7-oxononanoate synthase activity
H0I32_01205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H0I32_01220	COG1393	Belongs to the ArsC family
H0I32_01235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0I32_01245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0I32_01260	COG0745	RESPONSE REGULATOR receiver
H0I32_01265	COG5002	protein histidine kinase activity
H0I32_01270	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0I32_01305	COG3237	CsbD-like
H0I32_01310	COG1309	transcriptional regulator
H0I32_01320	COG0778	Nitroreductase
H0I32_01325	COG2130	NADP-dependent
H0I32_01330	COG1979	alcohol dehydrogenase
H0I32_01345	COG0352	thiamine-phosphate diphosphorylase activity
H0I32_01355	COG2066	Belongs to the glutaminase family
H0I32_01365	COG2308	Evidence 4 Homologs of previously reported genes of
H0I32_01365	COG2307	Protein conserved in bacteria
H0I32_01385	COG2308	Evidence 4 Homologs of previously reported genes of
H0I32_01390	COG1902	pentaerythritol trinitrate reductase activity
H0I32_01395	COG1289	transmembrane transporter activity
H0I32_01415	COG2176	DNA-directed DNA polymerase activity
H0I32_01425	COG1136	(ABC) transporter
H0I32_01425	COG0577	efflux transmembrane transporter activity
H0I32_01430	COG4181	ATPase activity
H0I32_01440	COG0513	Belongs to the DEAD box helicase family
H0I32_01450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0I32_01465	COG2274	protein secretion by the type I secretion system
H0I32_01480	COG2373	Large extracellular alpha-helical protein
H0I32_01485	COG1278	Cold shock
H0I32_01545	COG1187	pseudouridine synthase activity
H0I32_01555	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0I32_01575	COG0022	dehydrogenase e1 component
H0I32_01595	COG0813	purine-nucleoside phosphorylase activity
H0I32_01605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H0I32_01610	COG1288	antiporter activity
H0I32_01615	COG1193	negative regulation of DNA recombination
H0I32_01620	COG3011	Protein conserved in bacteria
H0I32_01675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H0I32_01680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H0I32_01685	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H0I32_01690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H0I32_01695	COG0561	phosphatase activity
H0I32_01705	COG3279	Response regulator of the LytR AlgR family
H0I32_01725	COG0305	Participates in initiation and elongation during chromosome replication
H0I32_01730	COG0825	malonyl-CoA metabolic process
H0I32_01745	COG0343	queuine tRNA-ribosyltransferase activity
H0I32_01750	COG3959	Transketolase, thiamine diphosphate binding domain
H0I32_01755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H0I32_01780	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H0I32_01785	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H0I32_01810	COG1233	COG1233 Phytoene dehydrogenase and related
H0I32_01825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I32_01845	COG0714	Associated with various cellular activities
H0I32_01850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0I32_01860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0I32_01885	COG0308	aminopeptidase N
H0I32_01890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0I32_01905	COG0427	acetyl-CoA hydrolase
H0I32_01965	COG0339	signal peptide processing
H0I32_01975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H0I32_01980	COG1461	Dihydroxyacetone kinase
H0I32_01985	COG2376	Dihydroxyacetone kinase
H0I32_02010	COG1454	alcohol dehydrogenase
H0I32_02025	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H0I32_02035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0I32_02050	COG0742	ribosomal rna small subunit methyltransferase
H0I32_02060	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0I32_02085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H0I32_02105	COG2885	chlorophyll binding
H0I32_02125	COG0259	pyridoxamine-phosphate oxidase activity
H0I32_02135	COG1234	tRNA 3'-trailer cleavage
H0I32_02145	COG0540	Belongs to the ATCase OTCase family
H0I32_02150	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H0I32_02165	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H0I32_02175	COG1705	Flagellar rod assembly protein muramidase FlgJ
H0I32_02175	COG1388	LysM domain
H0I32_02180	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H0I32_02200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0I32_02200	COG0047	phosphoribosylformylglycinamidine synthase activity
H0I32_02205	COG4585	Histidine kinase
H0I32_02210	COG2197	response regulator
H0I32_02215	COG1862	Preprotein translocase
H0I32_02225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0I32_02230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0I32_02235	COG1132	(ABC) transporter
H0I32_02245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0I32_02265	COG0542	response to heat
H0I32_02275	COG2986	histidine ammonia-lyase
H0I32_02280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I32_02285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I32_02290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0I32_02295	COG0460	homoserine dehydrogenase
H0I32_02295	COG0527	aspartate kinase activity
H0I32_02300	COG0083	homoserine kinase activity
H0I32_02310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0I32_02345	COG0516	GMP reductase activity
H0I32_02345	COG0517	IMP dehydrogenase activity
H0I32_02360	COG3487	Iron-regulated protein
H0I32_02390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H0I32_02440	COG0167	dihydroorotate dehydrogenase activity
H0I32_02445	COG0589	response to stress
H0I32_02450	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0I32_02480	COG1846	Transcriptional regulator
H0I32_02485	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0I32_02485	COG1024	Enoyl-CoA hydratase
H0I32_02490	COG0183	Belongs to the thiolase family
H0I32_02500	COG1960	acyl-CoA dehydrogenase activity
H0I32_02520	COG3387	PFAM Glycoside hydrolase 15-related
H0I32_02555	COG0783	Belongs to the Dps family
H0I32_02595	COG2205	protein histidine kinase activity
H0I32_02595	COG0784	Response regulator, receiver
H0I32_02620	COG0492	ferredoxin-NADP+ reductase activity
H0I32_02690	COG1012	belongs to the aldehyde dehydrogenase family
H0I32_02730	COG1858	cytochrome C peroxidase
H0I32_02770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0I32_02785	COG4206	TonB-dependent receptor
H0I32_02815	COG0572	uridine kinase
H0I32_02825	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0I32_02830	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0I32_02830	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0I32_02835	COG0612	Peptidase, M16
H0I32_02840	COG1192	Involved in chromosome partitioning
H0I32_02845	COG1475	DNA binding
H0I32_02855	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H0I32_02860	COG0681	Belongs to the peptidase S26 family
H0I32_02890	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0I32_02905	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H0I32_02915	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H0I32_02940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H0I32_02955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0I32_02980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0I32_02985	COG4166	transmembrane transport
H0I32_03000	COG0254	rRNA binding
H0I32_03015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0I32_03020	COG1132	(ABC) transporter
H0I32_03025	COG1595	DNA-templated transcription, initiation
H0I32_03100	COG1595	DNA-templated transcription, initiation
H0I32_03110	COG3279	Response regulator of the LytR AlgR family
H0I32_03125	COG3275	phosphorelay sensor kinase activity
H0I32_03155	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H0I32_03160	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H0I32_03170	COG1674	ftsk spoiiie
H0I32_03185	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0I32_03185	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0I32_03190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0I32_03205	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H0I32_03210	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H0I32_03220	COG0626	cystathionine gamma-synthase activity
H0I32_03225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H0I32_03225	COG1333	cytochrome c biogenesis protein
H0I32_03230	COG1970	mechanosensitive ion channel activity
H0I32_03245	COG0513	Belongs to the DEAD box helicase family
H0I32_03260	COG2217	Heavy metal translocating P-type atpase
H0I32_03270	COG3278	Belongs to the heme-copper respiratory oxidase family
H0I32_03285	COG0348	domain, Protein
H0I32_03305	COG1073	alpha beta
H0I32_03350	COG1482	cell wall glycoprotein biosynthetic process
H0I32_03360	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H0I32_03370	COG2885	chlorophyll binding
H0I32_03385	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H0I32_03395	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H0I32_03400	COG0085	RNA polymerase activity
H0I32_03405	COG0222	ribosome binding
H0I32_03410	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0I32_03415	COG0081	regulation of translation
H0I32_03420	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H0I32_03440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0I32_03465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H0I32_03470	COG4974	Belongs to the 'phage' integrase family
H0I32_03485	COG1115	amino acid carrier protein
H0I32_03490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0I32_03505	COG2205	protein histidine kinase activity
H0I32_03505	COG0784	Response regulator, receiver
H0I32_03515	COG2264	protein methyltransferase activity
H0I32_03530	COG0577	efflux transmembrane transporter activity
H0I32_03535	COG3876	Protein conserved in bacteria
H0I32_03540	COG0584	glycerophosphoryl diester phosphodiesterase
H0I32_03565	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H0I32_03580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H0I32_03605	COG4452	Inner membrane protein CreD
H0I32_03620	COG0300	oxidoreductase activity
H0I32_03635	COG1858	cytochrome C peroxidase
H0I32_03670	COG1047	Peptidyl-prolyl cis-trans
H0I32_03675	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0I32_03680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0I32_03700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H0I32_03715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0I32_03720	COG0512	Glutamine amidotransferase of anthranilate synthase
H0I32_03720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0I32_03725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0I32_03730	COG0134	indole-3-glycerol-phosphate synthase activity
H0I32_03735	COG0135	phosphoribosylanthranilate isomerase activity
H0I32_03740	COG0133	tryptophan synthase activity
H0I32_03745	COG2884	Cell division ATP-binding protein ftsE
H0I32_03750	COG0463	Glycosyl transferase, family 2
H0I32_03750	COG1216	Glycosyl transferase, family 2
H0I32_03755	COG1215	transferase activity, transferring glycosyl groups
H0I32_03765	COG0438	transferase activity, transferring glycosyl groups
H0I32_03780	COG2244	polysaccharide biosynthetic process
H0I32_03805	COG1217	gtp-binding protein TYPA
H0I32_03815	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H0I32_03835	COG0492	ferredoxin-NADP+ reductase activity
H0I32_03850	COG1595	DNA-templated transcription, initiation
H0I32_03860	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0I32_03860	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0I32_03860	COG1703	isobutyryl-CoA mutase activity
H0I32_03865	COG0788	formyltetrahydrofolate deformylase activity
H0I32_03880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H0I32_03885	COG0284	orotidine-5'-phosphate decarboxylase activity
H0I32_03890	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0I32_03895	COG1129	ABC transporter
H0I32_03905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H0I32_03915	COG0174	glutamine synthetase
H0I32_03940	COG2356	endonuclease I
H0I32_03960	COG0419	ATPase involved in DNA repair
H0I32_03965	COG0420	3'-5' exonuclease activity
H0I32_03970	COG3550	peptidyl-serine autophosphorylation
H0I32_03980	COG1396	sequence-specific DNA binding
H0I32_04015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H0I32_04145	COG0730	response to heat
H0I32_04165	COG2264	protein methyltransferase activity
H0I32_04175	COG0149	triose-phosphate isomerase activity
H0I32_04180	COG0601	transmembrane transport
H0I32_04195	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0I32_04220	COG1132	(ABC) transporter
H0I32_04225	COG0101	tRNA pseudouridine synthase activity
H0I32_04265	COG4251	negative regulation of phosphorylation
H0I32_04270	COG0784	Response regulator, receiver
H0I32_04365	COG0488	(ABC) transporter
H0I32_04375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0I32_04395	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0I32_04415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0I32_04445	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H0I32_04450	COG0459	protein refolding
H0I32_04460	COG2855	membrane
H0I32_04465	COG0583	DNA-binding transcription factor activity
H0I32_04495	COG1956	GAF domain-containing protein
H0I32_04505	COG0138	bifunctional purine biosynthesis protein purh
H0I32_04510	COG1077	Cell shape determining protein MreB Mrl
H0I32_04525	COG0768	penicillin binding
H0I32_04530	COG0772	Belongs to the SEDS family
H0I32_04535	COG0525	valine-tRNA ligase activity
H0I32_04545	COG0436	Aminotransferase
H0I32_04550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H0I32_04555	COG1595	DNA-templated transcription, initiation
H0I32_04575	COG1216	Glycosyl transferase, family 2
H0I32_04590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0I32_04595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0I32_04605	COG1663	tetraacyldisaccharide 4'-kinase activity
H0I32_04610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0I32_04635	COG2205	protein histidine kinase activity
H0I32_04635	COG0784	Response regulator, receiver
H0I32_04640	COG3844	kynureninase activity
H0I32_04650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0I32_04670	COG1028	Short-chain dehydrogenase reductase Sdr
H0I32_04675	COG0662	Cupin 2, conserved barrel domain protein
H0I32_04700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H0I32_04730	COG3340	Belongs to the peptidase S51 family
H0I32_04750	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0I32_04760	COG0427	acetyl-CoA hydrolase
H0I32_04780	COG2226	methyltransferase
H0I32_04785	COG2363	Small membrane protein
H0I32_04805	COG3279	Response regulator of the LytR AlgR family
H0I32_04810	COG3275	phosphorelay sensor kinase activity
H0I32_04845	COG3275	phosphorelay sensor kinase activity
H0I32_04850	COG1477	protein flavinylation
H0I32_04860	COG3447	MASE1 domain protein
H0I32_04860	COG5001	Diguanylate cyclase
H0I32_04860	COG5002	protein histidine kinase activity
H0I32_04865	COG0643	Histidine kinase
H0I32_04865	COG2198	Histidine kinase
H0I32_04865	COG0784	Response regulator, receiver
H0I32_04885	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H0I32_04890	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H0I32_04895	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H0I32_04900	COG1805	sodium ion transport
H0I32_04915	COG2967	ApaG domain
H0I32_04920	COG1012	belongs to the aldehyde dehydrogenase family
H0I32_04935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I32_04945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H0I32_04960	COG0357	Ribosomal RNA small subunit methyltransferase G
H0I32_04965	COG3239	Fatty acid desaturase
H0I32_04970	COG0436	Aminotransferase
H0I32_04995	COG0569	domain protein
H0I32_05000	COG2226	methyltransferase
H0I32_05010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0I32_05020	COG0191	fructose-bisphosphate aldolase activity
H0I32_05025	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H0I32_05030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H0I32_05035	COG1185	polyribonucleotide nucleotidyltransferase activity
H0I32_05045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H0I32_05050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H0I32_05055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H0I32_05065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0I32_05070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0I32_05090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0I32_05105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0I32_05155	COG1215	transferase activity, transferring glycosyl groups
H0I32_05165	COG1215	transferase activity, transferring glycosyl groups
H0I32_05175	COG1696	Membrane protein involved in D-alanine export
H0I32_05200	COG3955	Domain of unknown function (DUF1919)
H0I32_05205	COG1215	transferase activity, transferring glycosyl groups
H0I32_05245	COG0529	Catalyzes the synthesis of activated sulfate
H0I32_05255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0I32_05260	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H0I32_05290	COG3228	Belongs to the MtfA family
H0I32_05295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0I32_05300	COG0668	transmembrane transport
H0I32_05310	COG1538	Outer membrane efflux protein
H0I32_05320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0I32_05330	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H0I32_05340	COG0069	glutamate synthase activity
H0I32_05345	COG1289	transmembrane transporter activity
H0I32_05360	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H0I32_05380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H0I32_05385	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H0I32_05395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0I32_05485	COG0702	epimerase
H0I32_05490	COG4771	TonB-dependent receptor
H0I32_05520	COG1028	Short-chain dehydrogenase reductase Sdr
H0I32_05525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0I32_05530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0I32_05540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0I32_05550	COG4221	oxidoreductase activity
H0I32_05550	COG3321	synthase
H0I32_05550	COG0300	oxidoreductase activity
H0I32_05550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0I32_05560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0I32_05565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0I32_05595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0I32_05600	COG0463	Glycosyl transferase, family 2
H0I32_05635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H0I32_05650	COG1428	Deoxynucleoside kinase
H0I32_05670	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H0I32_05675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0I32_05685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0I32_05715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0I32_05725	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0I32_05730	COG0596	Alpha beta hydrolase
H0I32_05735	COG1950	PFAM Membrane protein of
H0I32_05740	COG0544	peptidyl-prolyl cis-trans isomerase activity
H0I32_05745	COG0740	serine-type endopeptidase activity
H0I32_05750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H0I32_05765	COG2204	response regulator
H0I32_05770	COG3275	phosphorelay sensor kinase activity
H0I32_05805	COG0668	transmembrane transport
H0I32_05810	COG1214	PFAM Peptidase M22, glycoprotease
H0I32_05825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0I32_05830	COG0577	efflux transmembrane transporter activity
H0I32_05830	COG1136	(ABC) transporter
H0I32_05835	COG1136	(ABC) transporter
H0I32_05835	COG0577	efflux transmembrane transporter activity
H0I32_05840	COG1136	(ABC) transporter
H0I32_05850	COG2322	membrane
H0I32_05855	COG1999	signal sequence binding
H0I32_05875	COG1845	cytochrome c oxidase, subunit III
H0I32_05880	COG0109	protoheme IX farnesyltransferase activity
H0I32_05905	COG0509	glycine decarboxylation via glycine cleavage system
H0I32_05915	COG0632	four-way junction helicase activity
H0I32_05920	COG0280	phosphate acetyltransferase
H0I32_05920	COG0281	malic enzyme
H0I32_05925	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H0I32_05930	COG2124	cytochrome p450
H0I32_05935	COG2255	four-way junction helicase activity
H0I32_05940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0I32_05945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H0I32_05965	COG3743	rRNA binding
H0I32_05965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H0I32_05970	COG0437	4 iron, 4 sulfur cluster binding
H0I32_05985	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H0I32_05990	COG0195	Participates in both transcription termination and antitermination
H0I32_05990	COG2251	uridine kinase activity
H0I32_05995	COG0779	Required for maturation of 30S ribosomal subunits
H0I32_06020	COG3118	belongs to the thioredoxin family
H0I32_06025	COG1408	metallophosphoesterase
H0I32_06045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0I32_06045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0I32_06060	COG1061	Type III restriction enzyme res subunit
H0I32_06065	COG1032	radical SAM domain protein
H0I32_06070	COG0488	(ABC) transporter
H0I32_06080	COG0009	L-threonylcarbamoyladenylate synthase
H0I32_06085	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0I32_06090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0I32_06095	COG0052	Belongs to the universal ribosomal protein uS2 family
H0I32_06100	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H0I32_06105	COG0528	UMP kinase activity
H0I32_06110	COG0233	cytoplasmic translational termination
H0I32_06145	COG0017	Asparaginyl-tRNA synthetase
H0I32_06150	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H0I32_06170	COG0848	biopolymer transport protein
H0I32_06180	COG0811	peptide transport
H0I32_06190	COG0252	asparaginase activity
H0I32_06195	COG0084	hydrolase, TatD family'
H0I32_06245	COG0567	Dehydrogenase, E1 component
H0I32_06265	COG4263	nitrous-oxide reductase activity
H0I32_06335	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
H0I32_06340	COG1959	2 iron, 2 sulfur cluster binding
H0I32_06355	COG1309	transcriptional regulator
H0I32_06375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H0I32_06390	COG1278	Cold shock
H0I32_06400	COG0590	tRNA wobble adenosine to inosine editing
H0I32_06410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H0I32_06415	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H0I32_06465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0I32_06480	COG2095	MarC family integral membrane protein
H0I32_06495	COG0793	Belongs to the peptidase S41A family
H0I32_06515	COG1410	methionine synthase
H0I32_06515	COG0646	methionine synthase
H0I32_06525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H0I32_06550	COG0702	epimerase
H0I32_06555	COG4771	TonB-dependent receptor
H0I32_06560	COG1609	Transcriptional regulator
H0I32_06565	COG0800	Aldolase
H0I32_06580	COG1028	Short-chain dehydrogenase reductase Sdr
H0I32_06585	COG2271	Major facilitator Superfamily
H0I32_06590	COG2186	Transcriptional regulator
H0I32_06600	COG0702	epimerase
H0I32_06605	COG4771	TonB-dependent receptor
H0I32_06655	COG0588	phosphoglycerate mutase activity
H0I32_06660	COG0028	Belongs to the TPP enzyme family
H0I32_06670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0I32_06670	COG1017	nitric oxide dioxygenase activity
H0I32_06675	COG0783	Belongs to the Dps family
H0I32_06680	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0I32_06680	COG1024	Enoyl-CoA hydratase
H0I32_06685	COG2095	MarC family integral membrane protein
H0I32_06690	COG0531	amino acid
H0I32_06695	COG2814	Major facilitator Superfamily
H0I32_06710	COG0745	RESPONSE REGULATOR receiver
H0I32_06715	COG5002	protein histidine kinase activity
H0I32_06735	COG0784	Response regulator, receiver
H0I32_06735	COG2205	protein histidine kinase activity
H0I32_06750	COG1785	Belongs to the alkaline phosphatase family
H0I32_06765	COG1136	(ABC) transporter
H0I32_06770	COG0523	cobalamin synthesis protein
H0I32_06775	COG0302	gtp cyclohydrolase
H0I32_06795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0I32_06800	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H0I32_06805	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0I32_06810	COG0322	excinuclease ABC activity
H0I32_06815	COG4067	protein conserved in archaea
H0I32_06815	COG0189	ligase activity
H0I32_06820	COG0189	ligase activity
H0I32_06830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0I32_06835	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H0I32_06850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0I32_06855	COG5183	chlorophyll binding
H0I32_06855	COG2133	pyrroloquinoline quinone binding
H0I32_06860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H0I32_06880	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H0I32_06885	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H0I32_06890	COG0297	glycogen (starch) synthase activity
H0I32_06895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0I32_06905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H0I32_06920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0I32_06935	COG3655	Transcriptional regulator
H0I32_06980	COG2268	Band 7 protein
H0I32_07010	COG1381	Involved in DNA repair and RecF pathway recombination
H0I32_07020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0I32_07030	COG0626	cystathionine gamma-synthase activity
H0I32_07065	COG1561	YicC-like family, N-terminal region
H0I32_07070	COG0194	GDP metabolic process
H0I32_07075	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H0I32_07080	COG0792	nuclease activity
H0I32_07095	COG1619	proteins homologs of microcin C7 resistance protein MccF
H0I32_07100	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0I32_07100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0I32_07150	COG0123	including yeast histone deacetylase and acetoin utilization protein
H0I32_07155	COG1528	Iron-storage protein
H0I32_07165	COG0629	single-stranded DNA binding
H0I32_07235	COG0656	L-ascorbic acid biosynthetic process
H0I32_07245	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H0I32_07260	COG0288	reversible hydration of carbon dioxide
H0I32_07270	COG0659	secondary active sulfate transmembrane transporter activity
H0I32_07295	COG2304	oxidoreductase activity
H0I32_07300	COG2304	oxidoreductase activity
H0I32_07315	COG0714	Associated with various cellular activities
H0I32_07325	COG4989	oxidoreductase activity
H0I32_07330	COG4221	oxidoreductase activity
H0I32_07355	COG1012	belongs to the aldehyde dehydrogenase family
H0I32_07375	COG4953	penicillin-binding protein 1C
H0I32_07415	COG0612	Peptidase, M16
H0I32_07420	COG0612	Peptidase, M16
H0I32_07425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H0I32_07430	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H0I32_07440	COG4771	TonB-dependent receptor
H0I32_07450	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H0I32_07455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0I32_07460	COG1053	succinate dehydrogenase
H0I32_07470	COG0490	domain, Protein
H0I32_07470	COG2985	domain, Protein
H0I32_07475	COG0006	proline dipeptidase activity
H0I32_07480	COG0527	aspartate kinase activity
H0I32_07495	COG0596	Alpha beta hydrolase
H0I32_07510	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0I32_07520	COG0316	Belongs to the HesB IscA family
H0I32_07525	COG0719	Fe-S assembly protein
H0I32_07535	COG0396	ATPase activity
H0I32_07540	COG0719	Fe-S assembly protein
H0I32_07545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H0I32_07555	COG2166	iron-sulfur cluster assembly
H0I32_07560	COG2151	metal-sulfur cluster biosynthetic enzyme
H0I32_07580	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H0I32_07585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0I32_07615	COG2954	triphosphatase activity
H0I32_07620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0I32_07625	COG0469	pyruvate kinase activity
H0I32_07635	COG0571	ribonuclease III activity
H0I32_07640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0I32_07645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0I32_07655	COG0328	RNA-DNA hybrid ribonuclease activity
H0I32_07655	COG3341	Caulimovirus viroplasmin
H0I32_07670	COG0351	phosphomethylpyrimidine kinase
H0I32_07670	COG0352	thiamine-phosphate diphosphorylase activity
H0I32_07705	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H0I32_07720	COG3842	ATPase activity
H0I32_07725	COG1505	serine-type exopeptidase activity
H0I32_07730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H0I32_07735	COG1970	mechanosensitive ion channel activity
H0I32_07740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0I32_07745	COG1435	thymidine kinase activity
H0I32_07760	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H0I32_07770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0I32_07775	COG1573	uracil-dna glycosylase
H0I32_07790	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H0I32_07790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0I32_07805	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0I32_07810	COG0720	synthase
H0I32_07840	COG5002	protein histidine kinase activity
H0I32_07840	COG2198	Histidine kinase
H0I32_07840	COG0784	Response regulator, receiver
H0I32_07880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0I32_07890	COG0439	Biotin carboxylase
H0I32_07895	COG0511	ligase activity, forming carbon-carbon bonds
H0I32_07900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0I32_07905	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H0I32_07915	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0I32_07935	COG1609	Transcriptional regulator
H0I32_07940	COG1028	Short-chain dehydrogenase reductase Sdr
H0I32_07945	COG1312	Catalyzes the dehydration of D-mannonate
H0I32_07950	COG1904	glucuronate isomerase
H0I32_07960	COG5002	protein histidine kinase activity
H0I32_07975	COG0346	lactoylglutathione lyase activity
H0I32_07980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H0I32_07985	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0I32_08010	COG0481	GTPase activity
H0I32_08025	COG3263	regulation of cellular component size
H0I32_08035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0I32_08055	COG0594	ribonuclease P activity
H0I32_08060	COG0793	Belongs to the peptidase S41A family
H0I32_08070	COG2153	protein acetylation
H0I32_08075	COG1230	cation diffusion facilitator family transporter
H0I32_08080	COG0698	ribose 5-phosphate isomerase
H0I32_08085	COG0557	exoribonuclease II activity
H0I32_08090	COG0393	Putative heavy-metal-binding
H0I32_08130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0I32_08145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0I32_08155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H0I32_08160	COG0445	tRNA wobble uridine modification
H0I32_08165	COG2226	methyltransferase
H0I32_08175	COG0470	DNA polymerase III
H0I32_08180	COG0126	phosphoglycerate kinase activity
H0I32_08190	COG0791	NLP P60 protein
H0I32_08190	COG1388	LysM domain
H0I32_08230	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H0I32_08245	COG2244	polysaccharide biosynthetic process
H0I32_08310	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H0I32_08325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0I32_08375	COG0356	it plays a direct role in the translocation of protons across the membrane
H0I32_08380	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0I32_08385	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H0I32_08390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0I32_08395	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H0I32_08400	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H0I32_08420	COG0756	dUTP diphosphatase activity
H0I32_08425	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H0I32_08460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0I32_08460	COG0758	DNA mediated transformation
H0I32_08475	COG0180	Tryptophanyl-tRNA synthetase
H0I32_08500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H0I32_08520	COG0826	peptidase U32
H0I32_08530	COG1774	PSP1 C-terminal conserved region
H0I32_08540	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H0I32_08545	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0I32_08575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0I32_08580	COG1253	flavin adenine dinucleotide binding
H0I32_08600	COG1522	sequence-specific DNA binding
H0I32_08620	COG0113	porphobilinogen synthase activity
H0I32_08630	COG3012	SEC-C Motif Domain Protein
H0I32_08635	COG0408	coproporphyrinogen oxidase activity
H0I32_08645	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H0I32_08650	COG0569	domain protein
H0I32_08655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0I32_08660	COG0181	hydroxymethylbilane synthase activity
H0I32_08665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H0I32_08715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H0I32_08725	COG1981	membrane
H0I32_08730	COG5000	phosphorelay sensor kinase activity
H0I32_08735	COG1024	Enoyl-CoA hydratase
H0I32_08750	COG2207	Transcriptional regulator
H0I32_08760	COG1418	mRNA catabolic process
H0I32_08790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0I32_08795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0I32_08800	COG1121	(ABC) transporter
H0I32_08805	COG0803	Belongs to the bacterial solute-binding protein 9 family
H0I32_08820	COG4771	TonB-dependent receptor
H0I32_08850	COG1999	signal sequence binding
H0I32_08905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0I32_08910	COG2239	Acts as a magnesium transporter
H0I32_08915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0I32_08920	COG1233	COG1233 Phytoene dehydrogenase and related
H0I32_08945	COG0527	aspartate kinase activity
H0I32_08955	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H0I32_08965	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0I32_08990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H0I32_09010	COG0517	IMP dehydrogenase activity
H0I32_09010	COG0516	GMP reductase activity
H0I32_09025	COG3590	peptidase
H0I32_09035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0I32_09040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H0I32_09050	COG0196	riboflavin kinase activity
H0I32_09060	COG0193	aminoacyl-tRNA hydrolase activity
H0I32_09100	COG3483	tryptophan 2,3-dioxygenase activity
H0I32_09110	COG0166	Belongs to the GPI family
H0I32_09125	COG4206	TonB-dependent receptor
H0I32_09125	COG1629	transport
H0I32_09145	COG1194	a g-specific adenine glycosylase
H0I32_09150	COG0776	regulation of translation
H0I32_09155	COG1530	ribonuclease E activity
H0I32_09170	COG0686	Belongs to the AlaDH PNT family
H0I32_09180	COG0495	leucyl-tRNA aminoacylation
H0I32_09185	COG2177	Part of the ABC transporter FtsEX involved in
H0I32_09200	COG1968	undecaprenyl-diphosphatase activity
H0I32_09205	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0I32_09220	COG0519	Catalyzes the synthesis of GMP from XMP
H0I32_09225	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H0I32_09235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0I32_09240	COG3852	Histidine kinase
H0I32_09255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0I32_09270	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H0I32_09295	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
H0I32_09305	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H0I32_09310	COG4717	serine-type aminopeptidase activity
H0I32_09315	COG0436	Aminotransferase
H0I32_09330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0I32_09350	COG0423	glycine-tRNA ligase activity
H0I32_09380	COG2072	flavoprotein involved in K transport
H0I32_09390	COG0708	Exodeoxyribonuclease III
H0I32_09395	COG1360	Flagellar Motor Protein
H0I32_09400	COG0667	Aldo Keto reductase
H0I32_09405	COG1522	sequence-specific DNA binding
H0I32_09415	COG2363	Small membrane protein
H0I32_09420	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H0I32_09435	COG0463	Glycosyl transferase, family 2
H0I32_09440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H0I32_09455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0I32_09470	COG0745	RESPONSE REGULATOR receiver
H0I32_09475	COG5002	protein histidine kinase activity
H0I32_09480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H0I32_09485	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0I32_09500	COG0489	protein tyrosine kinase activity
H0I32_09505	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H0I32_09510	COG0492	ferredoxin-NADP+ reductase activity
H0I32_09515	COG0633	Ferredoxin
H0I32_09530	COG1960	acyl-CoA dehydrogenase activity
H0I32_09535	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H0I32_09540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0I32_09545	COG0228	four-way junction DNA binding
H0I32_09570	COG1028	Short-chain dehydrogenase reductase Sdr
H0I32_09580	COG0596	Alpha beta hydrolase
H0I32_09605	COG4585	Histidine kinase
H0I32_09640	COG0463	Glycosyl transferase, family 2
H0I32_09655	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H0I32_09660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0I32_09675	COG2315	Protein conserved in bacteria
H0I32_09680	COG0784	Response regulator, receiver
H0I32_09690	COG4251	negative regulation of phosphorylation
H0I32_09700	COG5002	protein histidine kinase activity
H0I32_09710	COG3279	Response regulator of the LytR AlgR family
H0I32_09755	COG0745	RESPONSE REGULATOR receiver
H0I32_09765	COG1482	cell wall glycoprotein biosynthetic process
H0I32_09770	COG2824	Alkylphosphonate utilization operon protein PhnA
H0I32_09810	COG2814	Major facilitator Superfamily
H0I32_09820	COG0235	Class ii aldolase
H0I32_09825	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
H0I32_09835	COG1454	alcohol dehydrogenase
H0I32_09840	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H0I32_09845	COG0366	Alpha amylase catalytic
H0I32_09855	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H0I32_09860	COG4206	TonB-dependent receptor
H0I32_09860	COG1629	transport
H0I32_09875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0I32_09880	COG1554	hydrolase, family 65, central catalytic
H0I32_09885	COG1501	Belongs to the glycosyl hydrolase 31 family
H0I32_09895	COG0366	Alpha amylase catalytic
H0I32_09900	COG1082	Xylose isomerase domain protein TIM barrel
H0I32_09915	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H0I32_09935	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0I32_09955	COG2081	HI0933 family
H0I32_09985	COG1187	pseudouridine synthase activity
H0I32_09995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H0I32_10000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0I32_10005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H0I32_10010	COG1349	DNA-binding transcription factor activity
H0I32_10040	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
H0I32_10050	COG1166	arginine decarboxylase activity
H0I32_10055	COG0010	Belongs to the arginase family
H0I32_10060	COG1899	peptidyl-lysine modification to peptidyl-hypusine
H0I32_10065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0I32_10065	COG3153	acetyltransferase
H0I32_10095	COG1215	transferase activity, transferring glycosyl groups
H0I32_10110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0I32_10145	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H0I32_10175	COG1629	transport
H0I32_10175	COG4206	TonB-dependent receptor
H0I32_10195	COG0590	tRNA wobble adenosine to inosine editing
H0I32_10210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0I32_10230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0I32_10235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0I32_10240	COG0066	3-isopropylmalate dehydratase activity
H0I32_10255	COG0004	ammonium transporteR
H0I32_10265	COG0069	glutamate synthase activity
H0I32_10265	COG0070	glutamate synthase
H0I32_10265	COG0067	glutamate synthase
H0I32_10275	COG0165	Argininosuccinate lyase
H0I32_10285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0I32_10295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0I32_10305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H0I32_10310	COG0137	argininosuccinate synthase activity
H0I32_10320	COG1012	belongs to the aldehyde dehydrogenase family
H0I32_10325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0I32_10330	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H0I32_10340	COG0028	Belongs to the TPP enzyme family
H0I32_10345	COG0129	dihydroxy-acid dehydratase activity
H0I32_10355	COG4771	TonB-dependent receptor
H0I32_10395	COG0477	Major facilitator Superfamily
H0I32_10395	COG2814	Major facilitator Superfamily
H0I32_10405	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H0I32_10435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0I32_10450	COG0823	Involved in the tonB-independent uptake of proteins
H0I32_10450	COG1506	peptidase
H0I32_10455	COG3104	oligopeptide transport
H0I32_10470	COG0658	competence protein
H0I32_10470	COG2333	competence protein COMEC
H0I32_10475	COG0791	NLP P60 protein
H0I32_10480	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0I32_10485	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H0I32_10490	COG0793	Belongs to the peptidase S41A family
H0I32_10495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H0I32_10500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H0I32_10510	COG2001	Belongs to the MraZ family
H0I32_10515	COG0275	rRNA processing
H0I32_10530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0I32_10535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0I32_10540	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H0I32_10545	COG0772	Belongs to the SEDS family
H0I32_10550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H0I32_10555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0I32_10570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0I32_10575	COG1610	YqeY-like protein
H0I32_10630	COG5002	protein histidine kinase activity
H0I32_10635	COG0745	RESPONSE REGULATOR receiver
H0I32_10645	COG1428	Deoxynucleoside kinase
H0I32_10695	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H0I32_10700	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0I32_10705	COG1045	serine acetyltransferase
H0I32_10720	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0I32_10720	COG0022	dehydrogenase e1 component
H0I32_10725	COG2086	electron transfer activity
H0I32_10730	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H0I32_10740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H0I32_10745	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H0I32_10755	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H0I32_10760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H0I32_10765	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0I32_10770	COG1959	2 iron, 2 sulfur cluster binding
H0I32_10780	COG0175	sulfate reduction
H0I32_10785	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0I32_10795	COG1648	precorrin-2 dehydrogenase activity
H0I32_10795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H0I32_10800	COG0492	ferredoxin-NADP+ reductase activity
H0I32_10815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H0I32_10820	COG0280	phosphate acetyltransferase
H0I32_10820	COG0857	belongs to the CobB CobQ family
H0I32_10825	COG1131	(ABC) transporter
H0I32_10835	COG0436	Aminotransferase
H0I32_10840	COG0287	Prephenate dehydrogenase
H0I32_10845	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H0I32_10850	COG1162	GTPase activity
H0I32_10855	COG1490	D-aminoacyl-tRNA deacylase activity
H0I32_10880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H0I32_10885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H0I32_10890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H0I32_10925	COG2076	Multidrug Resistance protein
H0I32_10930	COG0358	DNA primase activity
H0I32_10935	COG2197	response regulator
H0I32_10940	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0I32_10975	COG1309	transcriptional regulator
H0I32_10980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0I32_10985	COG3396	Phenylacetate-CoA oxygenase
H0I32_10990	COG3460	Phenylacetate-CoA oxygenase
H0I32_10995	COG3396	Phenylacetate-CoA oxygenase
H0I32_11000	COG2151	metal-sulfur cluster biosynthetic enzyme
H0I32_11005	COG1024	Enoyl-CoA hydratase
H0I32_11010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0I32_11015	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0I32_11025	COG2321	neutral zinc metallopeptidase
H0I32_11030	COG0183	Belongs to the thiolase family
H0I32_11035	COG1012	belongs to the aldehyde dehydrogenase family
H0I32_11035	COG2030	dehydratase
H0I32_11055	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0I32_11060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0I32_11065	COG0022	dehydrogenase e1 component
H0I32_11075	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H0I32_11085	COG0351	phosphomethylpyrimidine kinase
H0I32_11090	COG0352	thiamine-phosphate diphosphorylase activity
H0I32_11095	COG2022	thiamine diphosphate biosynthetic process
H0I32_11100	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H0I32_11110	COG1278	Cold shock
H0I32_11115	COG0659	secondary active sulfate transmembrane transporter activity
H0I32_11125	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H0I32_11135	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H0I32_11145	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H0I32_11165	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H0I32_11170	COG0401	homolog of Blt101
H0I32_11180	COG0321	lipoyl(octanoyl) transferase activity
H0I32_11200	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0I32_11205	COG1629	transport
H0I32_11230	COG1404	Belongs to the peptidase S8 family
H0I32_11265	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0I32_11270	COG1960	acyl-CoA dehydrogenase activity
H0I32_11275	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H0I32_11290	COG0811	peptide transport
H0I32_11295	COG0848	biopolymer transport protein
H0I32_11305	COG0285	dihydrofolate synthase activity
H0I32_11320	COG2234	aminopeptidase activity
H0I32_11325	COG4935	Belongs to the peptidase S8 family
H0I32_11325	COG2234	aminopeptidase activity
H0I32_11345	COG0671	phosphoesterase, PA-phosphatase related
H0I32_11350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0I32_11355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0I32_11370	COG0295	cytidine deaminase activity
H0I32_11375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H0I32_11390	COG1028	Short-chain dehydrogenase reductase Sdr
H0I32_11395	COG0789	Transcriptional regulator
H0I32_11400	COG0484	heat shock protein binding
H0I32_11420	COG1127	ABC transporter
H0I32_11425	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0I32_11430	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
H0I32_11440	COG1216	Glycosyl transferase, family 2
H0I32_11450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0I32_11455	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H0I32_11455	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H0I32_11495	COG1510	regulation of RNA biosynthetic process
H0I32_11505	COG0339	signal peptide processing
H0I32_11515	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H0I32_11520	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H0I32_11525	COG0563	adenylate kinase activity
H0I32_11530	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H0I32_11535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0I32_11545	COG1028	Short-chain dehydrogenase reductase Sdr
H0I32_11595	COG2003	Belongs to the UPF0758 family
H0I32_11605	COG1011	Hydrolase
H0I32_11615	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0I32_11635	COG1629	transport
H0I32_11640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0I32_11655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H0I32_11660	COG0049	tRNA binding
H0I32_11665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H0I32_11670	COG0051	transcription antitermination factor activity, RNA binding
H0I32_11675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H0I32_11680	COG0088	Forms part of the polypeptide exit tunnel
H0I32_11685	COG0089	rRNA binding
H0I32_11690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H0I32_11695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H0I32_11700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H0I32_11705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H0I32_11710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H0I32_11715	COG0255	Belongs to the universal ribosomal protein uL29 family
H0I32_11720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H0I32_11725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H0I32_11730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H0I32_11735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H0I32_11740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H0I32_11745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H0I32_11750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H0I32_11755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H0I32_11760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H0I32_11765	COG1841	ribosomal large subunit assembly
H0I32_11770	COG0200	Binds to the 23S rRNA
H0I32_11780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H0I32_11785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H0I32_11790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H0I32_11795	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H0I32_11800	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H0I32_11805	COG0202	RNA polymerase activity
H0I32_11810	COG0203	ribosomal protein L17
H0I32_11820	COG0148	phosphopyruvate hydratase activity
H0I32_11840	COG0688	phosphatidylethanolamine metabolic process
H0I32_11855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0I32_11860	COG0799	negative regulation of ribosome biogenesis
H0I32_11875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H0I32_11895	COG0189	ligase activity
H0I32_11915	COG5002	protein histidine kinase activity
H0I32_11920	COG0018	arginyl-trna synthetase
H0I32_11950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0I32_11955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H0I32_11960	COG1187	pseudouridine synthase activity
H0I32_11970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H0I32_11970	COG0662	Cupin 2, conserved barrel domain protein
H0I32_11980	COG0433	COG0433 Predicted ATPase
H0I32_11985	COG0602	queuosine metabolic process
H0I32_12000	COG0367	asparagine synthase
H0I32_12015	COG0187	DNA topoisomerase II activity
H0I32_12035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0I32_12045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H0I32_12050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H0I32_12055	COG0215	cysteine-tRNA ligase activity
H0I32_12060	COG0302	gtp cyclohydrolase
H0I32_12085	COG0442	prolyl-tRNA aminoacylation
H0I32_12095	COG0268	Binds directly to 16S ribosomal RNA
H0I32_12100	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0I32_12125	COG0791	NLP P60 protein
H0I32_12125	COG1388	LysM domain
H0I32_12130	COG1160	GTP binding
H0I32_12160	COG0789	Transcriptional regulator
H0I32_12160	COG4978	Transcriptional regulator
H0I32_12170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H0I32_12180	COG2273	Hydrolase Family 16
H0I32_12180	COG5297	Belongs to the glycosyl hydrolase family 6
H0I32_12185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H0I32_12190	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0I32_12200	COG0564	pseudouridine synthase activity
H0I32_12205	COG3022	response to hydroperoxide
H0I32_12220	COG4771	TonB-dependent receptor
H0I32_12245	COG0513	Belongs to the DEAD box helicase family
H0I32_12255	COG4628	conserved protein (DUF2132)
H0I32_12260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H0I32_12275	COG0159	tryptophan synthase activity
H0I32_12300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0I32_12310	COG1538	Outer membrane efflux protein
H0I32_12325	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H0I32_12330	COG1733	regulation of RNA biosynthetic process
H0I32_12365	COG0753	catalase activity
H0I32_12380	COG1280	lysine exporter protein (LysE YggA)
H0I32_12385	COG0583	DNA-binding transcription factor activity
H0I32_12400	COG0640	Transcriptional regulator
H0I32_12425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0I32_12440	COG4585	Histidine kinase
H0I32_12445	COG2197	response regulator
H0I32_12460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H0I32_12465	COG0484	heat shock protein binding
H0I32_12470	COG4152	abc transporter atp-binding protein
H0I32_12475	COG1668	transmembrane transport
H0I32_12480	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H0I32_12480	COG3264	Mechanosensitive ion channel
H0I32_12495	COG2326	polyphosphate kinase activity
H0I32_12510	COG0019	diaminopimelate decarboxylase activity
H0I32_12520	COG0045	succinate-CoA ligase (ADP-forming) activity
H0I32_12545	COG0556	nucleotide-excision repair
H0I32_12590	COG1131	(ABC) transporter
H0I32_12605	COG1612	heme a metabolic process
H0I32_12615	COG0617	tRNA 3'-terminal CCA addition
H0I32_12615	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H0I32_12615	COG0517	IMP dehydrogenase activity
H0I32_12670	COG0463	Glycosyl transferase, family 2
H0I32_12675	COG0463	Glycosyl transferase, family 2
H0I32_12680	COG1216	Glycosyl transferase, family 2
H0I32_12680	COG0463	Glycosyl transferase, family 2
H0I32_12690	COG2171	N-acyltransferase activity
H0I32_12695	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0I32_12700	COG0242	peptide deformylase activity
H0I32_12710	COG3956	TIGRFAM MazG family protein
H0I32_12725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H0I32_12745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0I32_12755	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0I32_12765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0I32_12770	COG5658	integral membrane protein
H0I32_12775	COG0300	oxidoreductase activity
H0I32_12785	COG0501	Belongs to the peptidase M48B family
H0I32_12790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0I32_12815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H0I32_12825	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0I32_12830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0I32_12840	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H0I32_12850	COG0105	UTP biosynthetic process
H0I32_12855	COG4206	TonB-dependent receptor
H0I32_12885	COG2032	superoxide dismutase activity
H0I32_12895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0I32_12900	COG0589	response to stress
H0I32_12955	COG0513	Belongs to the DEAD box helicase family
H0I32_12960	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H0I32_12975	COG4206	TonB-dependent receptor
H0I32_12975	COG1629	transport
H0I32_12985	COG0326	Molecular chaperone. Has ATPase activity
H0I32_12990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0I32_13000	COG1482	cell wall glycoprotein biosynthetic process
H0I32_13030	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0I32_13040	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0I32_13045	COG1342	Belongs to the UPF0251 family
H0I32_13055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0I32_13055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0I32_13070	COG5002	protein histidine kinase activity
H0I32_13070	COG2198	Histidine kinase
H0I32_13070	COG0784	Response regulator, receiver
H0I32_13075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0I32_13080	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0I32_13090	COG1546	Belongs to the CinA family
H0I32_13090	COG1058	Belongs to the CinA family
H0I32_13095	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H0I32_13100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H0I32_13110	COG0552	protein localization to endoplasmic reticulum
H0I32_13125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0I32_13130	COG0612	Peptidase, M16
H0I32_13140	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H0I32_13145	COG0076	glutamate decarboxylase activity
H0I32_13150	COG0519	Catalyzes the synthesis of GMP from XMP
H0I32_13150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0I32_13170	COG0504	CTP synthase activity
H0I32_13175	COG0706	membrane insertase activity
H0I32_13185	COG0482	sulfurtransferase activity
H0I32_13200	COG3263	regulation of cellular component size
H0I32_13220	COG0534	Mate efflux family protein
H0I32_13230	COG0671	phosphoesterase, PA-phosphatase related
H0I32_13240	COG3952	Lipid A Biosynthesis
H0I32_13240	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0I32_13245	COG0463	Glycosyl transferase, family 2
H0I32_13270	COG1506	peptidase
H0I32_13270	COG0823	Involved in the tonB-independent uptake of proteins
H0I32_13275	COG2827	Endonuclease containing a URI domain
H0I32_13285	COG0653	protein targeting
H0I32_13300	COG1136	(ABC) transporter
H0I32_13310	COG0488	(ABC) transporter
H0I32_13320	COG3206	protein involved in exopolysaccharide biosynthesis
H0I32_13320	COG0489	protein tyrosine kinase activity
H0I32_13325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0I32_13330	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H0I32_13370	COG0457	Tetratricopeptide repeat
H0I32_13385	COG0463	Glycosyl transferase, family 2
H0I32_13395	COG1215	transferase activity, transferring glycosyl groups
H0I32_13400	COG0438	transferase activity, transferring glycosyl groups
H0I32_13435	COG1696	Membrane protein involved in D-alanine export
H0I32_13455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H0I32_13470	COG0438	transferase activity, transferring glycosyl groups
H0I32_13475	COG0463	Glycosyl transferase, family 2
H0I32_13505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0I32_13520	COG1183	phosphatidylcholine synthase activity
H0I32_13525	COG2354	Protein conserved in bacteria
H0I32_13535	COG1137	ATPase activity
H0I32_13545	COG0805	protein transport
H0I32_13550	COG0517	IMP dehydrogenase activity
H0I32_13550	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0I32_13555	COG0514	ATP-dependent DNA helicase (RecQ)
H0I32_13565	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0I32_13570	COG0693	protein deglycase activity
H0I32_13580	COG1607	acyl-coa hydrolase
H0I32_13595	COG1322	Protein conserved in bacteria
H0I32_13600	COG1120	ATPase activity
H0I32_13605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0I32_13670	COG0564	pseudouridine synthase activity
H0I32_13690	COG1028	Short-chain dehydrogenase reductase Sdr
H0I32_13705	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H0I32_13725	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H0I32_13740	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H0I32_13750	COG1295	ribonuclease BN
H0I32_13760	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0I32_13765	COG3279	Response regulator of the LytR AlgR family
H0I32_13770	COG0360	Binds together with S18 to 16S ribosomal RNA
H0I32_13775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H0I32_13780	COG0359	binds to the 23S rRNA
H0I32_13785	COG0584	glycerophosphoryl diester phosphodiesterase
H0I32_13795	COG1136	(ABC) transporter
H0I32_13795	COG0577	efflux transmembrane transporter activity
H0I32_13800	COG0124	histidyl-tRNA synthetase
H0I32_13825	COG3275	phosphorelay sensor kinase activity
H0I32_13830	COG3279	Response regulator of the LytR AlgR family
H0I32_13835	COG0471	metal ion transport
H0I32_13840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H0I32_13845	COG4585	Histidine kinase
H0I32_13920	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H0I32_13930	COG0732	type I restriction modification DNA specificity domain
H0I32_13940	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H0I32_13995	COG1858	cytochrome C peroxidase
H0I32_14025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0I32_14030	COG1678	Uncharacterized ACR, COG1678
H0I32_14035	COG0776	regulation of translation
H0I32_14040	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H0I32_14045	COG0514	ATP-dependent DNA helicase (RecQ)
H0I32_14065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H0I32_14070	COG0415	Belongs to the DNA photolyase family
H0I32_14085	COG0386	Belongs to the glutathione peroxidase family
H0I32_14095	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H0I32_14120	COG0335	large ribosomal subunit rRNA binding
H0I32_14130	COG0336	Belongs to the RNA methyltransferase TrmD family
H0I32_14135	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H0I32_14150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0I32_14155	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H0I32_14165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0I32_14180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H0I32_14185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0I32_14190	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0I32_14195	COG0824	Thioesterase
H0I32_14200	COG1739	Uncharacterized protein family UPF0029
H0I32_14210	COG1011	Hydrolase
H0I32_14215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0I32_14215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0I32_14230	COG2890	protein-(glutamine-N5) methyltransferase activity
H0I32_14235	COG1611	Belongs to the LOG family
H0I32_14240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0I32_14250	COG0737	Belongs to the 5'-nucleotidase family
H0I32_14265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0I32_14290	COG0497	DNA recombination
H0I32_14300	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H0I32_14325	COG2226	methyltransferase
H0I32_14330	COG0116	Belongs to the methyltransferase superfamily
H0I32_14330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H0I32_14340	COG2326	polyphosphate kinase activity
H0I32_14345	COG2326	polyphosphate kinase activity
H0I32_14360	COG1611	Belongs to the LOG family
H0I32_14370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0I32_14380	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
H0I32_14430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0I32_14440	COG1560	Kdo2-lipid A biosynthetic process
H0I32_14455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I32_14470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H0I32_14550	COG2217	Heavy metal translocating P-type atpase
H0I32_14625	COG1234	tRNA 3'-trailer cleavage
H0I32_14655	COG3279	Response regulator of the LytR AlgR family
H0I32_14725	COG0745	RESPONSE REGULATOR receiver
H0I32_14725	COG2972	Histidine kinase
H0I32_14730	COG3279	Response regulator of the LytR AlgR family
H0I32_14815	COG2197	response regulator
H0I32_14850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0I32_14870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0I32_15070	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
H0I32_15075	COG1691	(AIR) carboxylase
H0I32_15080	COG1606	tRNA processing
H0I32_15095	COG0471	metal ion transport
H0I32_15095	COG3273	potassium ion transport
H0I32_15125	COG1271	oxidase subunit
H0I32_15130	COG1294	oxidase, subunit
H0I32_15150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H0I32_15155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H0I32_15160	COG1335	isochorismatase
H0I32_15170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0I32_15190	COG3540	Alkaline phosphatase
H0I32_15200	COG0592	DNA-directed DNA polymerase activity
H0I32_15230	COG1702	phosphate starvation-inducible protein PhoH
H0I32_15240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H0I32_15265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0I32_15295	COG1104	cysteine desulfurase activity
H0I32_15325	COG1418	mRNA catabolic process
H0I32_15335	COG4974	Belongs to the 'phage' integrase family
H0I32_15360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0I32_15365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0I32_15370	COG0297	glycogen (starch) synthase activity
H0I32_15375	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H0I32_15380	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H0I32_15415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0I32_15415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H0I32_15420	COG0791	NLP P60 protein
H0I32_15425	COG0183	Belongs to the thiolase family
H0I32_15430	COG1480	7TM receptor with intracellular HD hydrolase
H0I32_15440	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0I32_15445	COG3119	arylsulfatase activity
H0I32_15450	COG3119	arylsulfatase activity
H0I32_15455	COG3119	arylsulfatase activity
H0I32_15485	COG3119	arylsulfatase activity
H0I32_15490	COG3119	arylsulfatase activity
H0I32_15495	COG3119	arylsulfatase activity
H0I32_15505	COG3119	arylsulfatase activity
H0I32_15515	COG3119	arylsulfatase activity
H0I32_15520	COG3119	arylsulfatase activity
H0I32_15530	COG3119	arylsulfatase activity
H0I32_15565	COG3119	arylsulfatase activity
H0I32_15575	COG3408	Glycogen debranching enzyme
H0I32_15575	COG3119	arylsulfatase activity
H0I32_15580	COG3119	arylsulfatase activity
H0I32_15590	COG3119	arylsulfatase activity
H0I32_15610	COG3119	arylsulfatase activity
H0I32_15620	COG2205	protein histidine kinase activity
H0I32_15620	COG0745	RESPONSE REGULATOR receiver
H0I32_15620	COG3292	Two component regulator propeller
H0I32_15625	COG1012	belongs to the aldehyde dehydrogenase family
H0I32_15630	COG0738	Major facilitator superfamily
H0I32_15635	COG0247	lactate metabolic process
H0I32_15640	COG1139	Iron-sulfur cluster binding protein
H0I32_15645	COG1556	Lactate utilization protein
H0I32_15675	COG0628	permease
H0I32_15700	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H0I32_15710	COG0205	6-phosphofructokinase activity
H0I32_15725	COG1803	Methylglyoxal synthase
H0I32_15745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0I32_15760	COG0488	(ABC) transporter
H0I32_15825	COG0714	Associated with various cellular activities
H0I32_15870	COG1022	Amp-dependent synthetase and ligase
H0I32_15875	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H0I32_15885	COG2801	Transposase and inactivated derivatives
H0I32_15900	COG3177	Filamentation induced by cAMP protein fic
H0I32_15995	COG3047	cAMP biosynthetic process
H0I32_15995	COG2885	chlorophyll binding
H0I32_16020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I32_16060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I32_16130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H0I32_16315	COG3609	addiction module antidote protein, CC2985 family
H0I32_16415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H0I32_16425	COG3634	alkyl hydroperoxide reductase activity
H0I32_16505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H0I32_16685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0I32_16725	COG2885	chlorophyll binding
H0I32_16725	COG3047	cAMP biosynthetic process
H0I32_16740	COG1695	Transcriptional regulator
H0I32_16885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I32_16905	COG4771	TonB-dependent receptor
H0I32_16930	COG4974	Belongs to the 'phage' integrase family
H0I32_16935	COG0217	transcriptional regulatory protein
H0I32_16945	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H0I32_16980	COG0277	FAD linked oxidase domain protein
H0I32_16980	COG0247	lactate metabolic process
H0I32_16990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H0I32_16995	COG1301	dicarboxylic acid transport
H0I32_17020	COG0302	gtp cyclohydrolase
H0I32_17035	COG3046	protein related to deoxyribodipyrimidine photolyase
H0I32_17050	COG0702	epimerase
H0I32_17070	COG0798	PFAM Bile acid sodium symporter
H0I32_17095	COG0673	inositol 2-dehydrogenase activity
H0I32_17110	COG0598	Magnesium transport protein CorA
H0I32_17125	COG0424	maF-like protein
H0I32_17135	COG0561	phosphatase activity
H0I32_17160	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H0I32_17175	COG0429	hydrolase of the alpha beta-hydrolase fold
H0I32_17205	COG0606	chelatase, subunit chli
H0I32_17230	COG0564	pseudouridine synthase activity
H0I32_17240	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H0I32_17260	COG1760	l-serine dehydratase
H0I32_17275	COG0443	Heat shock 70 kDa protein
H0I32_17300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H0I32_17305	COG2070	2-Nitropropane dioxygenase
H0I32_17310	COG4191	Histidine kinase
H0I32_17315	COG3279	Response regulator of the LytR AlgR family
H0I32_17335	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H0I32_17345	COG2996	Protein conserved in bacteria
H0I32_17360	COG1575	Belongs to the MenA family. Type 1 subfamily
H0I32_17365	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H0I32_17375	COG4948	Mandelate Racemase Muconate Lactonizing
H0I32_17390	COG2304	oxidoreductase activity
H0I32_17445	COG1216	Glycosyl transferase, family 2
H0I32_17445	COG0463	Glycosyl transferase, family 2
H0I32_17455	COG0237	dephospho-CoA kinase activity
H0I32_17470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H0I32_17475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0I32_17485	COG2176	DNA-directed DNA polymerase activity
H0I32_17500	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0I32_17505	COG0673	inositol 2-dehydrogenase activity
H0I32_17510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H0I32_17535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H0I32_17550	COG0813	purine-nucleoside phosphorylase activity
H0I32_17555	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H0I32_17565	COG0542	response to heat
H0I32_17580	COG0564	pseudouridine synthase activity
H0I32_17590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H0I32_17605	COG4946	Tricorn protease homolog
H0I32_17605	COG0823	Involved in the tonB-independent uptake of proteins
H0I32_17605	COG1506	peptidase
H0I32_17635	COG0300	oxidoreductase activity
H0I32_17640	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0I32_17650	COG0488	(ABC) transporter
H0I32_17660	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H0I32_17670	COG1119	ATPase activity
H0I32_17675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H0I32_17690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H0I32_17700	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0I32_17745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I32_17820	COG1595	DNA-templated transcription, initiation
H0I32_17895	COG0450	alkyl hydroperoxide reductase
H0I32_17900	COG1757	Na H antiporter
H0I32_17910	COG1522	sequence-specific DNA binding
H0I32_17920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0I32_17925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0I32_17930	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0I32_17970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0I32_17975	COG2217	Heavy metal translocating P-type atpase
H0I32_17995	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0I32_18020	COG0038	chloride channel
H0I32_18045	COG0246	Mannitol dehydrogenase
H0I32_18050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway