locus-tag	class	description
H7F37_00020	COG1077	Cell shape determining protein MreB Mrl
H7F37_00025	COG0138	bifunctional purine biosynthesis protein purh
H7F37_00080	COG2855	membrane
H7F37_00090	COG0459	protein refolding
H7F37_00095	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7F37_00120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7F37_00140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7F37_00160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7F37_00170	COG0488	(ABC) transporter
H7F37_00255	COG3011	Protein conserved in bacteria
H7F37_00260	COG1193	negative regulation of DNA recombination
H7F37_00265	COG1288	antiporter activity
H7F37_00270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7F37_00280	COG0813	purine-nucleoside phosphorylase activity
H7F37_00300	COG0022	dehydrogenase e1 component
H7F37_00330	COG1187	pseudouridine synthase activity
H7F37_00390	COG1278	Cold shock
H7F37_00395	COG2373	Large extracellular alpha-helical protein
H7F37_00425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7F37_00435	COG0513	Belongs to the DEAD box helicase family
H7F37_00445	COG4181	ATPase activity
H7F37_00450	COG1136	(ABC) transporter
H7F37_00450	COG0577	efflux transmembrane transporter activity
H7F37_00460	COG2176	DNA-directed DNA polymerase activity
H7F37_00480	COG1289	transmembrane transporter activity
H7F37_00485	COG1902	pentaerythritol trinitrate reductase activity
H7F37_00490	COG2308	Evidence 4 Homologs of previously reported genes of
H7F37_00510	COG2308	Evidence 4 Homologs of previously reported genes of
H7F37_00510	COG2307	Protein conserved in bacteria
H7F37_00520	COG2066	Belongs to the glutaminase family
H7F37_00530	COG0352	thiamine-phosphate diphosphorylase activity
H7F37_00545	COG1979	alcohol dehydrogenase
H7F37_00550	COG2130	NADP-dependent
H7F37_00555	COG0778	Nitroreductase
H7F37_00565	COG1309	transcriptional regulator
H7F37_00570	COG3237	CsbD-like
H7F37_00605	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7F37_00615	COG5002	protein histidine kinase activity
H7F37_00620	COG0745	RESPONSE REGULATOR receiver
H7F37_00635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7F37_00645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7F37_00660	COG1393	Belongs to the ArsC family
H7F37_00675	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7F37_00690	COG0156	8-amino-7-oxononanoate synthase activity
H7F37_00740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7F37_00760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7F37_00765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7F37_00820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7F37_00830	COG0463	Glycosyl transferase, family 2
H7F37_00840	COG2205	protein histidine kinase activity
H7F37_00840	COG0784	Response regulator, receiver
H7F37_00860	COG0251	oxidation-reduction process
H7F37_00870	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F37_00875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7F37_00880	COG2181	nitrate reductase activity
H7F37_00880	COG0247	lactate metabolic process
H7F37_00890	COG0247	lactate metabolic process
H7F37_00890	COG2181	nitrate reductase activity
H7F37_00920	COG0560	Phosphoserine phosphatase
H7F37_00920	COG3830	Belongs to the UPF0237 family
H7F37_00925	COG1472	Belongs to the glycosyl hydrolase 3 family
H7F37_00930	COG0438	transferase activity, transferring glycosyl groups
H7F37_00960	COG3275	phosphorelay sensor kinase activity
H7F37_00965	COG3279	Response regulator of the LytR AlgR family
H7F37_00985	COG0009	L-threonylcarbamoyladenylate synthase
H7F37_00990	COG2814	Major facilitator Superfamily
H7F37_00995	COG1132	(ABC) transporter
H7F37_01000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7F37_01005	COG0439	Biotin carboxylase
H7F37_01010	COG0511	ligase activity, forming carbon-carbon bonds
H7F37_01015	COG2339	peptidase activity
H7F37_01065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7F37_01085	COG1363	Peptidase, m42
H7F37_01090	COG1131	(ABC) transporter
H7F37_01105	COG1272	protein, Hemolysin III
H7F37_01110	COG0095	Lipoate-protein ligase
H7F37_01115	COG0346	lactoylglutathione lyase activity
H7F37_01120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7F37_01130	COG0511	ligase activity, forming carbon-carbon bonds
H7F37_01135	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H7F37_01140	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7F37_01145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7F37_01145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7F37_01155	COG1703	isobutyryl-CoA mutase activity
H7F37_01165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7F37_01170	COG1136	(ABC) transporter
H7F37_01175	COG1136	(ABC) transporter
H7F37_01175	COG0577	efflux transmembrane transporter activity
H7F37_01230	COG0071	Belongs to the small heat shock protein (HSP20) family
H7F37_01290	COG3118	belongs to the thioredoxin family
H7F37_01490	COG3275	phosphorelay sensor kinase activity
H7F37_01510	COG3279	Response regulator of the LytR AlgR family
H7F37_01530	COG1595	DNA-templated transcription, initiation
H7F37_01550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F37_01555	COG0010	Belongs to the arginase family
H7F37_01565	COG1228	amidohydrolase
H7F37_01635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7F37_01640	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7F37_01650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7F37_01675	COG0784	Response regulator, receiver
H7F37_01680	COG4251	negative regulation of phosphorylation
H7F37_01685	COG0012	GTP binding
H7F37_01720	COG1522	sequence-specific DNA binding
H7F37_01730	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7F37_01740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7F37_01745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H7F37_01760	COG0686	Belongs to the AlaDH PNT family
H7F37_01775	COG0802	atpase or kinase
H7F37_01780	COG2204	response regulator
H7F37_01785	COG1078	dGTPase activity
H7F37_01790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7F37_01795	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H7F37_01795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7F37_01800	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7F37_01805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7F37_01810	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7F37_01815	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H7F37_01820	COG1028	Short-chain dehydrogenase reductase Sdr
H7F37_01835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7F37_01840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7F37_01845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7F37_01850	COG0131	Imidazoleglycerol-phosphate dehydratase
H7F37_01860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7F37_01865	COG0107	imidazoleglycerol-phosphate synthase activity
H7F37_01870	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7F37_01870	COG0140	phosphoribosyl-ATP diphosphatase activity
H7F37_01875	COG0101	tRNA pseudouridine synthase activity
H7F37_01885	COG0668	transmembrane transport
H7F37_01915	COG0668	transmembrane transport
H7F37_01920	COG2814	Major facilitator Superfamily
H7F37_01935	COG1278	Cold shock
H7F37_01940	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H7F37_01955	COG4942	peptidase
H7F37_01965	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7F37_01970	COG1028	Short-chain dehydrogenase reductase Sdr
H7F37_01985	COG1278	Cold shock
H7F37_01990	COG1012	belongs to the aldehyde dehydrogenase family
H7F37_02005	COG2807	transmembrane transport
H7F37_02030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7F37_02065	COG0778	Nitroreductase
H7F37_02070	COG1733	regulation of RNA biosynthetic process
H7F37_02080	COG4251	negative regulation of phosphorylation
H7F37_02130	COG0069	glutamate synthase activity
H7F37_02140	COG0492	ferredoxin-NADP+ reductase activity
H7F37_02150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7F37_02160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7F37_02185	COG4251	negative regulation of phosphorylation
H7F37_02190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7F37_02195	COG0246	Mannitol dehydrogenase
H7F37_02220	COG0038	chloride channel
H7F37_02235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7F37_02245	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7F37_02260	COG2217	Heavy metal translocating P-type atpase
H7F37_02265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7F37_02305	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7F37_02310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F37_02315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7F37_02325	COG1522	sequence-specific DNA binding
H7F37_02335	COG1757	Na H antiporter
H7F37_02340	COG0450	alkyl hydroperoxide reductase
H7F37_02345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F37_02425	COG1595	DNA-templated transcription, initiation
H7F37_02450	COG3588	fructose-bisphosphate aldolase
H7F37_02455	COG0588	phosphoglycerate mutase activity
H7F37_02565	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F37_02575	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H7F37_02590	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7F37_02595	COG1119	ATPase activity
H7F37_02605	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H7F37_02615	COG0488	(ABC) transporter
H7F37_02625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7F37_02630	COG0300	oxidoreductase activity
H7F37_02660	COG0058	SHG alpha-glucan phosphorylase activity
H7F37_02665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7F37_02675	COG0564	pseudouridine synthase activity
H7F37_02690	COG0542	response to heat
H7F37_02700	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H7F37_02705	COG0813	purine-nucleoside phosphorylase activity
H7F37_02720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7F37_02745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7F37_02750	COG0673	inositol 2-dehydrogenase activity
H7F37_02755	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7F37_02770	COG2176	DNA-directed DNA polymerase activity
H7F37_02780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7F37_02785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7F37_02800	COG0237	dephospho-CoA kinase activity
H7F37_02810	COG0463	Glycosyl transferase, family 2
H7F37_02810	COG1216	Glycosyl transferase, family 2
H7F37_02870	COG2304	oxidoreductase activity
H7F37_02885	COG4948	Mandelate Racemase Muconate Lactonizing
H7F37_02890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7F37_02895	COG1575	Belongs to the MenA family. Type 1 subfamily
H7F37_02910	COG2996	Protein conserved in bacteria
H7F37_02920	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H7F37_02940	COG3279	Response regulator of the LytR AlgR family
H7F37_02945	COG4191	Histidine kinase
H7F37_02950	COG2070	2-Nitropropane dioxygenase
H7F37_02955	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7F37_02980	COG0443	Heat shock 70 kDa protein
H7F37_02995	COG1760	l-serine dehydratase
H7F37_03000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7F37_03010	COG0564	pseudouridine synthase activity
H7F37_03120	COG1204	response to ionizing radiation
H7F37_03155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7F37_03240	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7F37_03245	COG0037	tRNA processing
H7F37_03255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7F37_03265	COG0561	phosphatase activity
H7F37_03275	COG0424	maF-like protein
H7F37_03290	COG0598	Magnesium transport protein CorA
H7F37_03305	COG0673	inositol 2-dehydrogenase activity
H7F37_03330	COG0798	PFAM Bile acid sodium symporter
H7F37_03350	COG0702	epimerase
H7F37_03360	COG3046	protein related to deoxyribodipyrimidine photolyase
H7F37_03375	COG0302	gtp cyclohydrolase
H7F37_03400	COG1301	dicarboxylic acid transport
H7F37_03405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7F37_03415	COG0247	lactate metabolic process
H7F37_03415	COG0277	FAD linked oxidase domain protein
H7F37_03450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7F37_03460	COG0217	transcriptional regulatory protein
H7F37_03470	COG4974	Belongs to the 'phage' integrase family
H7F37_03590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F37_03870	COG3547	Transposase (IS116 IS110 IS902 family)
H7F37_04285	COG2274	protein secretion by the type I secretion system
H7F37_04405	COG3547	Transposase (IS116 IS110 IS902 family)
H7F37_04410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F37_04480	COG3547	Transposase (IS116 IS110 IS902 family)
H7F37_04530	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H7F37_04535	COG1022	Amp-dependent synthetase and ligase
H7F37_04580	COG0714	Associated with various cellular activities
H7F37_04600	COG0495	leucyl-tRNA aminoacylation
H7F37_04650	COG0488	(ABC) transporter
H7F37_04660	COG1741	Belongs to the pirin family
H7F37_04685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7F37_04705	COG1803	Methylglyoxal synthase
H7F37_04720	COG0205	6-phosphofructokinase activity
H7F37_04730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7F37_04755	COG0628	permease
H7F37_04785	COG1480	7TM receptor with intracellular HD hydrolase
H7F37_04790	COG0183	Belongs to the thiolase family
H7F37_04795	COG0791	NLP P60 protein
H7F37_04800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7F37_04800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7F37_04825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7F37_04830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7F37_04835	COG0297	glycogen (starch) synthase activity
H7F37_04840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7F37_04845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7F37_04870	COG4974	Belongs to the 'phage' integrase family
H7F37_04880	COG1418	mRNA catabolic process
H7F37_04910	COG1104	cysteine desulfurase activity
H7F37_04940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7F37_04965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7F37_04975	COG1702	phosphate starvation-inducible protein PhoH
H7F37_05005	COG0592	DNA-directed DNA polymerase activity
H7F37_05015	COG3540	Alkaline phosphatase
H7F37_05035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7F37_05045	COG1335	isochorismatase
H7F37_05050	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7F37_05055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7F37_05070	COG1129	ABC transporter
H7F37_05070	COG0842	Transport permease protein
H7F37_05075	COG0842	Transport permease protein
H7F37_05080	COG1131	(ABC) transporter
H7F37_05085	COG1131	(ABC) transporter
H7F37_05090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7F37_05110	COG1294	oxidase, subunit
H7F37_05115	COG1271	oxidase subunit
H7F37_05155	COG1606	tRNA processing
H7F37_05160	COG1691	(AIR) carboxylase
H7F37_05165	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
H7F37_05360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7F37_05380	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7F37_05415	COG2197	response regulator
H7F37_05490	COG3279	Response regulator of the LytR AlgR family
H7F37_05495	COG0745	RESPONSE REGULATOR receiver
H7F37_05495	COG2972	Histidine kinase
H7F37_05575	COG3279	Response regulator of the LytR AlgR family
H7F37_05595	COG0739	heme binding
H7F37_05665	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H7F37_05680	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7F37_05690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F37_05705	COG1560	Kdo2-lipid A biosynthetic process
H7F37_05715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7F37_05770	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
H7F37_05780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7F37_05790	COG1611	Belongs to the LOG family
H7F37_05805	COG2326	polyphosphate kinase activity
H7F37_05810	COG2326	polyphosphate kinase activity
H7F37_05820	COG0116	Belongs to the methyltransferase superfamily
H7F37_05820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7F37_05825	COG2226	methyltransferase
H7F37_05850	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7F37_05860	COG0497	DNA recombination
H7F37_05885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7F37_05900	COG0737	Belongs to the 5'-nucleotidase family
H7F37_05910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7F37_05915	COG1611	Belongs to the LOG family
H7F37_05920	COG2890	protein-(glutamine-N5) methyltransferase activity
H7F37_05935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7F37_05935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7F37_05940	COG1011	Hydrolase
H7F37_05950	COG1739	Uncharacterized protein family UPF0029
H7F37_05955	COG0824	Thioesterase
H7F37_05960	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7F37_05965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7F37_05970	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7F37_05985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7F37_05995	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7F37_06000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7F37_06015	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H7F37_06020	COG0336	Belongs to the RNA methyltransferase TrmD family
H7F37_06030	COG0335	large ribosomal subunit rRNA binding
H7F37_06055	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H7F37_06065	COG0386	Belongs to the glutathione peroxidase family
H7F37_06080	COG0415	Belongs to the DNA photolyase family
H7F37_06085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7F37_06105	COG0514	ATP-dependent DNA helicase (RecQ)
H7F37_06110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7F37_06120	COG1678	Uncharacterized ACR, COG1678
H7F37_06125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7F37_06145	COG1858	cytochrome C peroxidase
H7F37_06185	COG3829	transcription factor binding
H7F37_06200	COG1401	restriction endodeoxyribonuclease activity
H7F37_06205	COG0210	DNA helicase
H7F37_06205	COG0210	DNA helicase
H7F37_06205	COG0210	DNA helicase
H7F37_06210	COG0328	RNA-DNA hybrid ribonuclease activity
H7F37_06315	COG4585	Histidine kinase
H7F37_06320	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H7F37_06325	COG0471	metal ion transport
H7F37_06330	COG3279	Response regulator of the LytR AlgR family
H7F37_06365	COG0124	histidyl-tRNA synthetase
H7F37_06370	COG0577	efflux transmembrane transporter activity
H7F37_06370	COG1136	(ABC) transporter
H7F37_06380	COG0584	glycerophosphoryl diester phosphodiesterase
H7F37_06385	COG0359	binds to the 23S rRNA
H7F37_06390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7F37_06395	COG0360	Binds together with S18 to 16S ribosomal RNA
H7F37_06400	COG3279	Response regulator of the LytR AlgR family
H7F37_06405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7F37_06415	COG1295	ribonuclease BN
H7F37_06425	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7F37_06440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7F37_06460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H7F37_06475	COG1028	Short-chain dehydrogenase reductase Sdr
H7F37_06495	COG0564	pseudouridine synthase activity
H7F37_06560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F37_06565	COG1120	ATPase activity
H7F37_06570	COG1322	Protein conserved in bacteria
H7F37_06585	COG1607	acyl-coa hydrolase
H7F37_06595	COG0693	protein deglycase activity
H7F37_06600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7F37_06610	COG0514	ATP-dependent DNA helicase (RecQ)
H7F37_06615	COG0517	IMP dehydrogenase activity
H7F37_06615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H7F37_06620	COG0805	protein transport
H7F37_06630	COG1137	ATPase activity
H7F37_06640	COG2354	Protein conserved in bacteria
H7F37_06645	COG1183	phosphatidylcholine synthase activity
H7F37_06660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7F37_06690	COG0438	transferase activity, transferring glycosyl groups
H7F37_06720	COG2089	acid synthase
H7F37_06725	COG1083	cytidylyl-transferase
H7F37_06730	COG0367	asparagine synthase
H7F37_06745	COG1216	Glycosyl transferase, family 2
H7F37_06750	COG0463	Glycosyl transferase, family 2
H7F37_06755	COG1216	Glycosyl transferase, family 2
H7F37_06755	COG0463	Glycosyl transferase, family 2
H7F37_06790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7F37_06800	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H7F37_06805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7F37_06810	COG3206	protein involved in exopolysaccharide biosynthesis
H7F37_06810	COG0489	protein tyrosine kinase activity
H7F37_06820	COG0488	(ABC) transporter
H7F37_06830	COG1136	(ABC) transporter
H7F37_06845	COG0653	protein targeting
H7F37_06855	COG1506	peptidase
H7F37_06855	COG0823	Involved in the tonB-independent uptake of proteins
H7F37_06865	COG2827	Endonuclease containing a URI domain
H7F37_06870	COG2827	Endonuclease containing a URI domain
H7F37_06885	COG0463	Glycosyl transferase, family 2
H7F37_06890	COG3952	Lipid A Biosynthesis
H7F37_06890	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7F37_06900	COG0671	phosphoesterase, PA-phosphatase related
H7F37_06910	COG0534	Mate efflux family protein
H7F37_06930	COG3263	regulation of cellular component size
H7F37_06945	COG0482	sulfurtransferase activity
H7F37_06955	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H7F37_06960	COG0706	membrane insertase activity
H7F37_06965	COG0504	CTP synthase activity
H7F37_06980	COG1388	LysM domain
H7F37_06980	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F37_06985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7F37_06985	COG0519	Catalyzes the synthesis of GMP from XMP
H7F37_06990	COG0076	glutamate decarboxylase activity
H7F37_06995	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H7F37_07005	COG0612	Peptidase, M16
H7F37_07010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7F37_07025	COG0552	protein localization to endoplasmic reticulum
H7F37_07035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7F37_07040	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7F37_07045	COG1058	Belongs to the CinA family
H7F37_07045	COG1546	Belongs to the CinA family
H7F37_07055	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7F37_07060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7F37_07065	COG0784	Response regulator, receiver
H7F37_07065	COG2198	Histidine kinase
H7F37_07065	COG5002	protein histidine kinase activity
H7F37_07080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F37_07080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F37_07090	COG1342	Belongs to the UPF0251 family
H7F37_07095	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F37_07105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7F37_07135	COG1482	cell wall glycoprotein biosynthetic process
H7F37_07145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7F37_07150	COG0326	Molecular chaperone. Has ATPase activity
H7F37_07160	COG4206	TonB-dependent receptor
H7F37_07160	COG1629	transport
H7F37_07175	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H7F37_07180	COG0513	Belongs to the DEAD box helicase family
H7F37_07220	COG0589	response to stress
H7F37_07225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7F37_07235	COG2032	superoxide dismutase activity
H7F37_07265	COG4206	TonB-dependent receptor
H7F37_07270	COG0105	UTP biosynthetic process
H7F37_07280	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7F37_07290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7F37_07295	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7F37_07305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7F37_07330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7F37_07335	COG0501	Belongs to the peptidase M48B family
H7F37_07345	COG0300	oxidoreductase activity
H7F37_07350	COG5658	integral membrane protein
H7F37_07355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7F37_07365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7F37_07375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7F37_07395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7F37_07410	COG3956	TIGRFAM MazG family protein
H7F37_07420	COG0242	peptide deformylase activity
H7F37_07425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7F37_07430	COG2171	N-acyltransferase activity
H7F37_07440	COG1216	Glycosyl transferase, family 2
H7F37_07440	COG0463	Glycosyl transferase, family 2
H7F37_07445	COG1216	Glycosyl transferase, family 2
H7F37_07450	COG0463	Glycosyl transferase, family 2
H7F37_07485	COG0517	IMP dehydrogenase activity
H7F37_07485	COG0617	tRNA 3'-terminal CCA addition
H7F37_07485	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7F37_07490	COG1612	heme a metabolic process
H7F37_07505	COG1131	(ABC) transporter
H7F37_07550	COG0556	nucleotide-excision repair
H7F37_07575	COG0045	succinate-CoA ligase (ADP-forming) activity
H7F37_07585	COG0019	diaminopimelate decarboxylase activity
H7F37_07595	COG2326	polyphosphate kinase activity
H7F37_07610	COG3264	Mechanosensitive ion channel
H7F37_07610	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H7F37_07615	COG1668	transmembrane transport
H7F37_07620	COG4152	abc transporter atp-binding protein
H7F37_07625	COG0484	heat shock protein binding
H7F37_07630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7F37_07650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7F37_07675	COG0640	Transcriptional regulator
H7F37_07690	COG0583	DNA-binding transcription factor activity
H7F37_07695	COG1280	lysine exporter protein (LysE YggA)
H7F37_07715	COG0583	DNA-binding transcription factor activity
H7F37_07750	COG1733	regulation of RNA biosynthetic process
H7F37_07755	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7F37_07770	COG1538	Outer membrane efflux protein
H7F37_07800	COG0159	tryptophan synthase activity
H7F37_07815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7F37_07830	COG4628	conserved protein (DUF2132)
H7F37_07840	COG0513	Belongs to the DEAD box helicase family
H7F37_07865	COG4771	TonB-dependent receptor
H7F37_07880	COG3022	response to hydroperoxide
H7F37_07885	COG0564	pseudouridine synthase activity
H7F37_07895	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7F37_07900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7F37_07905	COG5297	Belongs to the glycosyl hydrolase family 6
H7F37_07905	COG2273	Hydrolase Family 16
H7F37_07915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7F37_07925	COG0789	Transcriptional regulator
H7F37_07925	COG4978	Transcriptional regulator
H7F37_07955	COG1160	GTP binding
H7F37_07960	COG1388	LysM domain
H7F37_07960	COG0791	NLP P60 protein
H7F37_07985	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H7F37_07990	COG0268	Binds directly to 16S ribosomal RNA
H7F37_08000	COG0442	prolyl-tRNA aminoacylation
H7F37_08025	COG0302	gtp cyclohydrolase
H7F37_08030	COG0215	cysteine-tRNA ligase activity
H7F37_08035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7F37_08040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7F37_08050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7F37_08070	COG0187	DNA topoisomerase II activity
H7F37_08080	COG0367	asparagine synthase
H7F37_08095	COG0602	queuosine metabolic process
H7F37_08100	COG0433	COG0433 Predicted ATPase
H7F37_08110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7F37_08110	COG0662	Cupin 2, conserved barrel domain protein
H7F37_08120	COG1187	pseudouridine synthase activity
H7F37_08125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7F37_08130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7F37_08160	COG0018	arginyl-trna synthetase
H7F37_08165	COG5002	protein histidine kinase activity
H7F37_08185	COG0189	ligase activity
H7F37_08205	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7F37_08220	COG0799	negative regulation of ribosome biogenesis
H7F37_08225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7F37_08240	COG0688	phosphatidylethanolamine metabolic process
H7F37_08260	COG0148	phosphopyruvate hydratase activity
H7F37_08270	COG0203	ribosomal protein L17
H7F37_08275	COG0202	RNA polymerase activity
H7F37_08280	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7F37_08285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7F37_08290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7F37_08295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7F37_08300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7F37_08305	COG0201	protein transport
H7F37_08310	COG0200	Binds to the 23S rRNA
H7F37_08315	COG1841	ribosomal large subunit assembly
H7F37_08320	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7F37_08325	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7F37_08330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7F37_08335	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7F37_08340	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7F37_08345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7F37_08350	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7F37_08355	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7F37_08360	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7F37_08365	COG0255	Belongs to the universal ribosomal protein uL29 family
H7F37_08370	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7F37_08375	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7F37_08380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7F37_08385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7F37_08390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7F37_08395	COG0089	rRNA binding
H7F37_08400	COG0088	Forms part of the polypeptide exit tunnel
H7F37_08405	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7F37_08410	COG0051	transcription antitermination factor activity, RNA binding
H7F37_08415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7F37_08420	COG0049	tRNA binding
H7F37_08425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7F37_08435	COG4771	TonB-dependent receptor
H7F37_08455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7F37_08465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7F37_08475	COG1011	Hydrolase
H7F37_08485	COG2003	Belongs to the UPF0758 family
H7F37_08535	COG1028	Short-chain dehydrogenase reductase Sdr
H7F37_08555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7F37_08560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7F37_08565	COG0563	adenylate kinase activity
H7F37_08570	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7F37_08575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7F37_08585	COG0339	signal peptide processing
H7F37_08595	COG1510	regulation of RNA biosynthetic process
H7F37_08635	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7F37_08635	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7F37_08640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7F37_08650	COG0275	rRNA processing
H7F37_08655	COG1215	transferase activity, transferring glycosyl groups
H7F37_08670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7F37_08675	COG1127	ABC transporter
H7F37_08695	COG0484	heat shock protein binding
H7F37_08700	COG0789	Transcriptional regulator
H7F37_08720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7F37_08725	COG0295	cytidine deaminase activity
H7F37_08740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7F37_08745	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7F37_08750	COG0671	phosphoesterase, PA-phosphatase related
H7F37_08775	COG0358	DNA primase activity
H7F37_08805	COG1196	nuclear chromosome segregation
H7F37_08825	COG2234	aminopeptidase activity
H7F37_08830	COG2234	aminopeptidase activity
H7F37_08845	COG0285	dihydrofolate synthase activity
H7F37_08855	COG0848	biopolymer transport protein
H7F37_08860	COG0811	peptide transport
H7F37_08875	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H7F37_08880	COG1960	acyl-CoA dehydrogenase activity
H7F37_08885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7F37_08920	COG1404	Belongs to the peptidase S8 family
H7F37_08940	COG1629	transport
H7F37_08945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7F37_08965	COG0321	lipoyl(octanoyl) transferase activity
H7F37_08975	COG0401	homolog of Blt101
H7F37_08990	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H7F37_09035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7F37_09045	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H7F37_09055	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7F37_09065	COG0659	secondary active sulfate transmembrane transporter activity
H7F37_09070	COG1278	Cold shock
H7F37_09080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7F37_09085	COG2022	thiamine diphosphate biosynthetic process
H7F37_09090	COG0352	thiamine-phosphate diphosphorylase activity
H7F37_09095	COG0351	phosphomethylpyrimidine kinase
H7F37_09095	COG0352	thiamine-phosphate diphosphorylase activity
H7F37_09095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H7F37_09105	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7F37_09115	COG0022	dehydrogenase e1 component
H7F37_09120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7F37_09125	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F37_09150	COG2030	dehydratase
H7F37_09150	COG1012	belongs to the aldehyde dehydrogenase family
H7F37_09155	COG0183	Belongs to the thiolase family
H7F37_09160	COG2321	neutral zinc metallopeptidase
H7F37_09170	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7F37_09175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7F37_09180	COG1024	Enoyl-CoA hydratase
H7F37_09185	COG2151	metal-sulfur cluster biosynthetic enzyme
H7F37_09190	COG3396	Phenylacetate-CoA oxygenase
H7F37_09195	COG3460	Phenylacetate-CoA oxygenase
H7F37_09200	COG3396	Phenylacetate-CoA oxygenase
H7F37_09205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7F37_09210	COG1309	transcriptional regulator
H7F37_09240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7F37_09245	COG2197	response regulator
H7F37_09250	COG0358	DNA primase activity
H7F37_09255	COG2076	Multidrug Resistance protein
H7F37_09290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7F37_09295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7F37_09300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7F37_09325	COG1490	D-aminoacyl-tRNA deacylase activity
H7F37_09330	COG1162	GTPase activity
H7F37_09335	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H7F37_09340	COG0287	Prephenate dehydrogenase
H7F37_09345	COG0436	Aminotransferase
H7F37_09355	COG1131	(ABC) transporter
H7F37_09360	COG0280	phosphate acetyltransferase
H7F37_09360	COG0857	belongs to the CobB CobQ family
H7F37_09365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7F37_09380	COG0492	ferredoxin-NADP+ reductase activity
H7F37_09385	COG1648	precorrin-2 dehydrogenase activity
H7F37_09385	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7F37_09395	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7F37_09400	COG0175	sulfate reduction
H7F37_09410	COG1959	2 iron, 2 sulfur cluster binding
H7F37_09415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H7F37_09420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7F37_09435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7F37_09440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7F37_09450	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H7F37_09455	COG2086	electron transfer activity
H7F37_09460	COG0022	dehydrogenase e1 component
H7F37_09460	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F37_09475	COG1045	serine acetyltransferase
H7F37_09480	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7F37_09485	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H7F37_09535	COG1428	Deoxynucleoside kinase
H7F37_09550	COG1610	YqeY-like protein
H7F37_09555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7F37_09570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7F37_09575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7F37_09580	COG0772	Belongs to the SEDS family
H7F37_09585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7F37_09590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7F37_09595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7F37_09610	COG0275	rRNA processing
H7F37_09615	COG2001	Belongs to the MraZ family
H7F37_09625	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7F37_09630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7F37_09635	COG0793	Belongs to the peptidase S41A family
H7F37_09640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7F37_09645	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7F37_09650	COG0791	NLP P60 protein
H7F37_09655	COG0658	competence protein
H7F37_09655	COG2333	competence protein COMEC
H7F37_09670	COG3104	oligopeptide transport
H7F37_09675	COG0823	Involved in the tonB-independent uptake of proteins
H7F37_09675	COG1506	peptidase
H7F37_09690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7F37_09720	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H7F37_09730	COG2814	Major facilitator Superfamily
H7F37_09730	COG0477	Major facilitator Superfamily
H7F37_09770	COG1629	transport
H7F37_09780	COG0129	dihydroxy-acid dehydratase activity
H7F37_09785	COG0028	Belongs to the TPP enzyme family
H7F37_09795	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7F37_09800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7F37_09805	COG1012	belongs to the aldehyde dehydrogenase family
H7F37_09815	COG0137	argininosuccinate synthase activity
H7F37_09820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7F37_09840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7F37_09850	COG0165	Argininosuccinate lyase
H7F37_09860	COG0067	glutamate synthase
H7F37_09860	COG0069	glutamate synthase activity
H7F37_09860	COG0070	glutamate synthase
H7F37_09870	COG0004	ammonium transporteR
H7F37_09885	COG0066	3-isopropylmalate dehydratase activity
H7F37_09890	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7F37_09895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7F37_09915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7F37_09930	COG0590	tRNA wobble adenosine to inosine editing
H7F37_09950	COG4206	TonB-dependent receptor
H7F37_09950	COG1629	transport
H7F37_09980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H7F37_10015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7F37_10030	COG1215	transferase activity, transferring glycosyl groups
H7F37_10060	COG3153	acetyltransferase
H7F37_10060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7F37_10065	COG1899	peptidyl-lysine modification to peptidyl-hypusine
H7F37_10070	COG0010	Belongs to the arginase family
H7F37_10075	COG1166	arginine decarboxylase activity
H7F37_10085	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
H7F37_10110	COG1349	DNA-binding transcription factor activity
H7F37_10115	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7F37_10120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7F37_10125	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7F37_10135	COG1187	pseudouridine synthase activity
H7F37_10160	COG0784	Response regulator, receiver
H7F37_10160	COG2205	protein histidine kinase activity
H7F37_10165	COG2081	HI0933 family
H7F37_10180	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7F37_10200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7F37_10215	COG1082	Xylose isomerase domain protein TIM barrel
H7F37_10220	COG0366	Alpha amylase catalytic
H7F37_10230	COG1501	Belongs to the glycosyl hydrolase 31 family
H7F37_10235	COG1554	hydrolase, family 65, central catalytic
H7F37_10240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7F37_10255	COG4206	TonB-dependent receptor
H7F37_10255	COG1629	transport
H7F37_10260	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7F37_10270	COG0366	Alpha amylase catalytic
H7F37_10275	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H7F37_10280	COG1454	alcohol dehydrogenase
H7F37_10285	COG2814	Major facilitator Superfamily
H7F37_10320	COG2824	Alkylphosphonate utilization operon protein PhnA
H7F37_10325	COG1482	cell wall glycoprotein biosynthetic process
H7F37_10335	COG0745	RESPONSE REGULATOR receiver
H7F37_10385	COG3279	Response regulator of the LytR AlgR family
H7F37_10395	COG5002	protein histidine kinase activity
H7F37_10405	COG4251	negative regulation of phosphorylation
H7F37_10415	COG0784	Response regulator, receiver
H7F37_10420	COG2315	Protein conserved in bacteria
H7F37_10435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7F37_10440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7F37_10455	COG0463	Glycosyl transferase, family 2
H7F37_10490	COG4585	Histidine kinase
H7F37_10515	COG0596	Alpha beta hydrolase
H7F37_10525	COG1028	Short-chain dehydrogenase reductase Sdr
H7F37_10545	COG0228	four-way junction DNA binding
H7F37_10550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7F37_10555	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H7F37_10560	COG1960	acyl-CoA dehydrogenase activity
H7F37_10580	COG0633	Ferredoxin
H7F37_10585	COG0492	ferredoxin-NADP+ reductase activity
H7F37_10590	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H7F37_10595	COG0489	protein tyrosine kinase activity
H7F37_10610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7F37_10615	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7F37_10620	COG5002	protein histidine kinase activity
H7F37_10625	COG0745	RESPONSE REGULATOR receiver
H7F37_10640	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7F37_10655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7F37_10660	COG0463	Glycosyl transferase, family 2
H7F37_10675	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H7F37_10680	COG2363	Small membrane protein
H7F37_10690	COG1522	sequence-specific DNA binding
H7F37_10695	COG0667	Aldo Keto reductase
H7F37_10700	COG1360	Flagellar Motor Protein
H7F37_10705	COG0708	Exodeoxyribonuclease III
H7F37_10715	COG2072	flavoprotein involved in K transport
H7F37_10750	COG1040	competence protein
H7F37_10760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7F37_10775	COG0436	Aminotransferase
H7F37_10780	COG4717	serine-type aminopeptidase activity
H7F37_10795	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H7F37_10805	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
H7F37_10830	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H7F37_10845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7F37_10860	COG3852	Histidine kinase
H7F37_10865	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7F37_10875	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H7F37_10880	COG0519	Catalyzes the synthesis of GMP from XMP
H7F37_10895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7F37_10900	COG1968	undecaprenyl-diphosphatase activity
H7F37_10915	COG2177	Part of the ABC transporter FtsEX involved in
H7F37_10920	COG0495	leucyl-tRNA aminoacylation
H7F37_10930	COG0686	Belongs to the AlaDH PNT family
H7F37_10945	COG1530	ribonuclease E activity
H7F37_10950	COG0776	regulation of translation
H7F37_10955	COG1194	a g-specific adenine glycosylase
H7F37_10975	COG4206	TonB-dependent receptor
H7F37_10975	COG1629	transport
H7F37_10990	COG0166	Belongs to the GPI family
H7F37_11010	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H7F37_11020	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7F37_11070	COG0193	aminoacyl-tRNA hydrolase activity
H7F37_11080	COG0196	riboflavin kinase activity
H7F37_11090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7F37_11095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7F37_11105	COG3590	peptidase
H7F37_11120	COG0516	GMP reductase activity
H7F37_11120	COG0517	IMP dehydrogenase activity
H7F37_11140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7F37_11160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7F37_11170	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H7F37_11180	COG0527	aspartate kinase activity
H7F37_11205	COG1233	COG1233 Phytoene dehydrogenase and related
H7F37_11210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7F37_11215	COG2239	Acts as a magnesium transporter
H7F37_11220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7F37_11275	COG1999	signal sequence binding
H7F37_11305	COG4771	TonB-dependent receptor
H7F37_11310	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7F37_11315	COG1121	(ABC) transporter
H7F37_11320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7F37_11325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7F37_11350	COG1418	mRNA catabolic process
H7F37_11365	COG2207	Transcriptional regulator
H7F37_11380	COG1024	Enoyl-CoA hydratase
H7F37_11385	COG5000	phosphorelay sensor kinase activity
H7F37_11390	COG1981	membrane
H7F37_11400	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7F37_11455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7F37_11460	COG0181	hydroxymethylbilane synthase activity
H7F37_11465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7F37_11470	COG0569	domain protein
H7F37_11475	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7F37_11485	COG0408	coproporphyrinogen oxidase activity
H7F37_11490	COG3012	SEC-C Motif Domain Protein
H7F37_11500	COG0113	porphobilinogen synthase activity
H7F37_11520	COG1522	sequence-specific DNA binding
H7F37_11540	COG1253	flavin adenine dinucleotide binding
H7F37_11545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7F37_11580	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7F37_11585	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H7F37_11595	COG1774	PSP1 C-terminal conserved region
H7F37_11605	COG0826	peptidase U32
H7F37_11625	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7F37_11650	COG0180	Tryptophanyl-tRNA synthetase
H7F37_11670	COG0758	DNA mediated transformation
H7F37_11670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7F37_11705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7F37_11710	COG0756	dUTP diphosphatase activity
H7F37_11730	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7F37_11735	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7F37_11740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7F37_11745	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7F37_11750	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7F37_11755	COG0356	it plays a direct role in the translocation of protons across the membrane
H7F37_11810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7F37_11825	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7F37_11865	COG0110	maltose O-acetyltransferase activity
H7F37_11895	COG3551	Protein conserved in bacteria
H7F37_11920	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H7F37_11960	COG3584	3D domain protein
H7F37_11960	COG1388	LysM domain
H7F37_11970	COG0126	phosphoglycerate kinase activity
H7F37_11975	COG0470	DNA polymerase III
H7F37_11985	COG2226	methyltransferase
H7F37_11990	COG0445	tRNA wobble uridine modification
H7F37_11995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7F37_12005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7F37_12020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7F37_12060	COG0393	Putative heavy-metal-binding
H7F37_12065	COG0557	exoribonuclease II activity
H7F37_12070	COG0698	ribose 5-phosphate isomerase
H7F37_12075	COG1230	cation diffusion facilitator family transporter
H7F37_12080	COG2153	protein acetylation
H7F37_12090	COG0793	Belongs to the peptidase S41A family
H7F37_12095	COG0594	ribonuclease P activity
H7F37_12115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F37_12125	COG3263	regulation of cellular component size
H7F37_12140	COG0481	GTPase activity
H7F37_12175	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7F37_12180	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7F37_12185	COG0346	lactoylglutathione lyase activity
H7F37_12205	COG5002	protein histidine kinase activity
H7F37_12215	COG1904	glucuronate isomerase
H7F37_12220	COG1312	Catalyzes the dehydration of D-mannonate
H7F37_12225	COG1028	Short-chain dehydrogenase reductase Sdr
H7F37_12230	COG1609	Transcriptional regulator
H7F37_12245	COG0307	riboflavin synthase, alpha
H7F37_12250	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7F37_12260	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7F37_12265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7F37_12270	COG0511	ligase activity, forming carbon-carbon bonds
H7F37_12275	COG0439	Biotin carboxylase
H7F37_12285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7F37_12305	COG0156	8-amino-7-oxononanoate synthase activity
H7F37_12345	COG0358	DNA primase activity
H7F37_12400	COG0534	Mate efflux family protein
H7F37_12415	COG0720	synthase
H7F37_12420	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7F37_12435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H7F37_12435	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H7F37_12450	COG1573	uracil-dna glycosylase
H7F37_12455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7F37_12465	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7F37_12480	COG1435	thymidine kinase activity
H7F37_12485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7F37_12490	COG1970	mechanosensitive ion channel activity
H7F37_12495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7F37_12500	COG1505	serine-type exopeptidase activity
H7F37_12505	COG3842	ATPase activity
H7F37_12520	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H7F37_12550	COG3541	Predicted nucleotidyltransferase
H7F37_12565	COG0351	phosphomethylpyrimidine kinase
H7F37_12565	COG0352	thiamine-phosphate diphosphorylase activity
H7F37_12580	COG0328	RNA-DNA hybrid ribonuclease activity
H7F37_12580	COG3341	Caulimovirus viroplasmin
H7F37_12590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7F37_12595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7F37_12600	COG0571	ribonuclease III activity
H7F37_12610	COG0469	pyruvate kinase activity
H7F37_12615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7F37_12620	COG2954	triphosphatase activity
H7F37_12650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7F37_12675	COG2151	metal-sulfur cluster biosynthetic enzyme
H7F37_12680	COG2166	iron-sulfur cluster assembly
H7F37_12690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7F37_12695	COG0719	Fe-S assembly protein
H7F37_12700	COG0396	ATPase activity
H7F37_12710	COG0719	Fe-S assembly protein
H7F37_12715	COG0316	Belongs to the HesB IscA family
H7F37_12725	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7F37_12740	COG0596	Alpha beta hydrolase
H7F37_12755	COG0527	aspartate kinase activity
H7F37_12760	COG0006	proline dipeptidase activity
H7F37_12765	COG2985	domain, Protein
H7F37_12765	COG0490	domain, Protein
H7F37_12775	COG1053	succinate dehydrogenase
H7F37_12780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7F37_12785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7F37_12795	COG4771	TonB-dependent receptor
H7F37_12805	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7F37_12810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7F37_12815	COG0612	Peptidase, M16
H7F37_12820	COG0612	Peptidase, M16
H7F37_12860	COG4953	penicillin-binding protein 1C
H7F37_12880	COG1012	belongs to the aldehyde dehydrogenase family
H7F37_12900	COG4221	oxidoreductase activity
H7F37_12905	COG4989	oxidoreductase activity
H7F37_12915	COG0714	Associated with various cellular activities
H7F37_12930	COG2304	oxidoreductase activity
H7F37_12960	COG0659	secondary active sulfate transmembrane transporter activity
H7F37_12970	COG0288	reversible hydration of carbon dioxide
H7F37_12985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7F37_12990	COG0469	pyruvate kinase activity
H7F37_12995	COG0656	L-ascorbic acid biosynthetic process
H7F37_13040	COG0629	single-stranded DNA binding
H7F37_13050	COG1528	Iron-storage protein
H7F37_13055	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7F37_13095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F37_13095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F37_13100	COG1619	proteins homologs of microcin C7 resistance protein MccF
H7F37_13115	COG0792	nuclease activity
H7F37_13120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7F37_13125	COG0194	GDP metabolic process
H7F37_13130	COG1561	YicC-like family, N-terminal region
H7F37_13165	COG0626	cystathionine gamma-synthase activity
H7F37_13175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7F37_13185	COG1381	Involved in DNA repair and RecF pathway recombination
H7F37_13220	COG2268	Band 7 protein
H7F37_13265	COG3655	Transcriptional regulator
H7F37_13275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7F37_13290	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7F37_13300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7F37_13310	COG0297	glycogen (starch) synthase activity
H7F37_13315	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7F37_13320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H7F37_13340	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H7F37_13350	COG5183	chlorophyll binding
H7F37_13350	COG2133	pyrroloquinoline quinone binding
H7F37_13355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7F37_13400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7F37_13405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7F37_13415	COG0189	ligase activity
H7F37_13420	COG4067	protein conserved in archaea
H7F37_13420	COG0189	ligase activity
H7F37_13425	COG0322	excinuclease ABC activity
H7F37_13430	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7F37_13435	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7F37_13440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7F37_13475	COG5002	protein histidine kinase activity
H7F37_13480	COG0745	RESPONSE REGULATOR receiver
H7F37_13495	COG0484	heat shock protein binding
H7F37_13515	COG2814	Major facilitator Superfamily
H7F37_13520	COG0531	amino acid
H7F37_13525	COG2095	MarC family integral membrane protein
H7F37_13530	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7F37_13530	COG1024	Enoyl-CoA hydratase
H7F37_13535	COG0783	Belongs to the Dps family
H7F37_13540	COG1017	nitric oxide dioxygenase activity
H7F37_13540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7F37_13550	COG0028	Belongs to the TPP enzyme family
H7F37_13555	COG0588	phosphoglycerate mutase activity
H7F37_13590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7F37_13665	COG0588	phosphoglycerate mutase activity
H7F37_13715	COG4771	TonB-dependent receptor
H7F37_13720	COG0702	epimerase
H7F37_13730	COG2186	Transcriptional regulator
H7F37_13735	COG2271	Major facilitator Superfamily
H7F37_13745	COG1609	Transcriptional regulator
H7F37_13755	COG0800	Aldolase
H7F37_13760	COG1609	Transcriptional regulator
H7F37_13765	COG4771	TonB-dependent receptor
H7F37_13770	COG0702	epimerase
H7F37_13795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H7F37_13805	COG0646	methionine synthase
H7F37_13805	COG1410	methionine synthase
H7F37_13825	COG0793	Belongs to the peptidase S41A family
H7F37_13840	COG2095	MarC family integral membrane protein
H7F37_13855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7F37_13900	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H7F37_13905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7F37_13925	COG1278	Cold shock
H7F37_13940	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7F37_13945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7F37_13960	COG1309	transcriptional regulator
H7F37_13975	COG1959	2 iron, 2 sulfur cluster binding
H7F37_13980	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
H7F37_14045	COG4263	nitrous-oxide reductase activity
H7F37_14060	COG0567	Dehydrogenase, E1 component
H7F37_14105	COG0084	hydrolase, TatD family'
H7F37_14110	COG0252	asparaginase activity
H7F37_14120	COG0811	peptide transport
H7F37_14130	COG0848	biopolymer transport protein
H7F37_14150	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7F37_14155	COG0017	Asparaginyl-tRNA synthetase
H7F37_14190	COG0233	cytoplasmic translational termination
H7F37_14195	COG0528	UMP kinase activity
H7F37_14200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7F37_14205	COG0052	Belongs to the universal ribosomal protein uS2 family
H7F37_14210	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7F37_14215	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7F37_14220	COG0009	L-threonylcarbamoyladenylate synthase
H7F37_14230	COG0488	(ABC) transporter
H7F37_14235	COG1032	radical SAM domain protein
H7F37_14245	COG2852	Protein conserved in bacteria
H7F37_14280	COG0270	DNA (cytosine-5-)-methyltransferase activity
H7F37_14285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7F37_14285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7F37_14305	COG1408	metallophosphoesterase
H7F37_14310	COG3118	belongs to the thioredoxin family
H7F37_14335	COG0779	Required for maturation of 30S ribosomal subunits
H7F37_14340	COG0195	Participates in both transcription termination and antitermination
H7F37_14340	COG2251	uridine kinase activity
H7F37_14345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7F37_14360	COG0437	4 iron, 4 sulfur cluster binding
H7F37_14365	COG3743	rRNA binding
H7F37_14365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7F37_14385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7F37_14390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7F37_14395	COG2255	four-way junction helicase activity
H7F37_14400	COG2124	cytochrome p450
H7F37_14405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7F37_14410	COG0280	phosphate acetyltransferase
H7F37_14410	COG0281	malic enzyme
H7F37_14415	COG0632	four-way junction helicase activity
H7F37_14425	COG0509	glycine decarboxylation via glycine cleavage system
H7F37_14450	COG0109	protoheme IX farnesyltransferase activity
H7F37_14455	COG1845	cytochrome c oxidase, subunit III
H7F37_14475	COG1999	signal sequence binding
H7F37_14480	COG2322	membrane
H7F37_14490	COG1136	(ABC) transporter
H7F37_14495	COG0577	efflux transmembrane transporter activity
H7F37_14495	COG1136	(ABC) transporter
H7F37_14500	COG0577	efflux transmembrane transporter activity
H7F37_14500	COG1136	(ABC) transporter
H7F37_14505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7F37_14520	COG1214	PFAM Peptidase M22, glycoprotease
H7F37_14525	COG0668	transmembrane transport
H7F37_14560	COG3275	phosphorelay sensor kinase activity
H7F37_14580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7F37_14585	COG0740	serine-type endopeptidase activity
H7F37_14590	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7F37_14595	COG1950	PFAM Membrane protein of
H7F37_14600	COG0596	Alpha beta hydrolase
H7F37_14605	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H7F37_14615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7F37_14645	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H7F37_14655	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7F37_14660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H7F37_14680	COG1428	Deoxynucleoside kinase
H7F37_14685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7F37_14695	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7F37_14710	COG0745	RESPONSE REGULATOR receiver
H7F37_14710	COG2205	protein histidine kinase activity
H7F37_14710	COG3292	Two component regulator propeller
H7F37_14745	COG0463	Glycosyl transferase, family 2
H7F37_14750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7F37_14780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7F37_14785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7F37_14795	COG0300	oxidoreductase activity
H7F37_14795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7F37_14795	COG4221	oxidoreductase activity
H7F37_14795	COG3321	synthase
H7F37_14805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7F37_14815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7F37_14820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7F37_14825	COG1028	Short-chain dehydrogenase reductase Sdr
H7F37_14830	COG2986	histidine ammonia-lyase
H7F37_14850	COG4771	TonB-dependent receptor
H7F37_14855	COG0702	epimerase
H7F37_14945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7F37_14955	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7F37_14960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7F37_14965	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H7F37_14980	COG1289	transmembrane transporter activity
H7F37_14985	COG0069	glutamate synthase activity
H7F37_14995	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7F37_15005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7F37_15015	COG1538	Outer membrane efflux protein
H7F37_15025	COG0668	transmembrane transport
H7F37_15030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7F37_15035	COG3228	Belongs to the MtfA family
H7F37_15065	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H7F37_15070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7F37_15080	COG0529	Catalyzes the synthesis of activated sulfate
H7F37_15105	COG1132	(ABC) transporter
H7F37_15120	COG0562	UDP-galactopyranose mutase
H7F37_15140	COG0463	Glycosyl transferase, family 2
H7F37_15150	COG1215	transferase activity, transferring glycosyl groups
H7F37_15155	COG0297	glycogen (starch) synthase activity
H7F37_15155	COG0438	transferase activity, transferring glycosyl groups
H7F37_15175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7F37_15190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7F37_15210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7F37_15215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7F37_15225	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7F37_15230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H7F37_15235	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7F37_15245	COG1185	polyribonucleotide nucleotidyltransferase activity
H7F37_15250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7F37_15255	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7F37_15260	COG0191	fructose-bisphosphate aldolase activity
H7F37_15270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7F37_15280	COG2226	methyltransferase
H7F37_15285	COG0569	domain protein
H7F37_15305	COG0436	Aminotransferase
H7F37_15310	COG3239	Fatty acid desaturase
H7F37_15315	COG0357	Ribosomal RNA small subunit methyltransferase G
H7F37_15325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7F37_15335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F37_15350	COG1012	belongs to the aldehyde dehydrogenase family
H7F37_15360	COG2967	ApaG domain
H7F37_15380	COG1805	sodium ion transport
H7F37_15385	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7F37_15390	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7F37_15395	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7F37_15415	COG2198	Histidine kinase
H7F37_15415	COG0784	Response regulator, receiver
H7F37_15415	COG0643	Histidine kinase
H7F37_15420	COG5002	protein histidine kinase activity
H7F37_15420	COG5001	Diguanylate cyclase
H7F37_15420	COG3447	MASE1 domain protein
H7F37_15430	COG1477	protein flavinylation
H7F37_15435	COG3275	phosphorelay sensor kinase activity
H7F37_15465	COG2363	Small membrane protein
H7F37_15470	COG2226	methyltransferase
H7F37_15490	COG0427	acetyl-CoA hydrolase
H7F37_15500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H7F37_15510	COG3340	Belongs to the peptidase S51 family
H7F37_15540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7F37_15565	COG0662	Cupin 2, conserved barrel domain protein
H7F37_15570	COG1028	Short-chain dehydrogenase reductase Sdr
H7F37_15590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7F37_15600	COG3844	kynureninase activity
H7F37_15605	COG0784	Response regulator, receiver
H7F37_15605	COG2205	protein histidine kinase activity
H7F37_15630	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7F37_15635	COG1663	tetraacyldisaccharide 4'-kinase activity
H7F37_15645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7F37_15650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7F37_15665	COG1216	Glycosyl transferase, family 2
H7F37_15685	COG1595	DNA-templated transcription, initiation
H7F37_15690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7F37_15695	COG0436	Aminotransferase
H7F37_15705	COG0525	valine-tRNA ligase activity
H7F37_15710	COG0772	Belongs to the SEDS family