locus-tag	class	description
WPG_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
WPG_0002	ENOG4105KJF	protein tyrosine phosphatase
WPG_0007	ENOG4105HHA	aminodeoxychorismate lyase
WPG_0009	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
WPG_0010	ENOG4105C0H	protease
WPG_0015	ENOG4108NEV	two component transcriptional regulator, LytTR family
WPG_0018	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
WPG_0022	ENOG4108HRK	Histidine kinase
WPG_0027	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
WPG_0028	ENOG4105SFS	phosphoesterase RecJ domain protein
WPG_0030	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
WPG_0032	ENOG4105VEJ	Heat shock protein
WPG_0033	ENOG4105FQ6	thiopurine methyltransferase
WPG_0034	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
WPG_0035	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
WPG_0037	ENOG4105EWK	phytoene
WPG_0040	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WPG_0042	ENOG4108I0Z	Aconitate hydratase
WPG_0043	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
WPG_0044	ENOG41085KW	ppic-type peptidyL-prolyl cis-trans isomerase
WPG_0046	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
WPG_0052	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
WPG_0065	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
WPG_0066	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
WPG_0069	ENOG4105VIE	preprotein translocase, subunit YajC
WPG_0071	ENOG4107R6T	Involved in the transcription termination process (By similarity)
WPG_0072	ENOG4107RDP	Dehydrogenase
WPG_0073	ENOG4105BZ1	(ABC) transporter
WPG_0076	ENOG4108Z7R	Chaperone CsaA
WPG_0079	ENOG41068WN	
WPG_0082	ENOG4105CEP	NADH dehydrogenase
WPG_0088	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
WPG_0090	ENOG4105EN6	Membrane
WPG_0096	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
WPG_0103	ENOG4105C5Q	Transcriptional regulator
WPG_0113	ENOG4105C3M	thioredoxin reductase
WPG_0115	ENOG4105D8V	Glucose sorbosone dehydrogenase
WPG_0119	ENOG4105CMN	Methylmalonyl-coA mutase
WPG_0121	ENOG4105D5P	Methylmalonyl-coA mutase
WPG_0123	ENOG4107QJE	Chromosome Partitioning Protein
WPG_0124	ENOG4105FA0	parb-like partition protein
WPG_0126	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
WPG_0127	ENOG4105C3F	Signal peptidase i
WPG_0132	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
WPG_0135	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
WPG_0137	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
WPG_0145	ENOG4105CZV	ABC transporter
WPG_0147	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
WPG_0149	ENOG4105C9U	ATP-dependent DNA helicase RecQ
WPG_0150	ENOG4105C2X	Arabinose 5-phosphate isomerase
WPG_0151	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
WPG_0153	ENOG4108IUZ	ABC transporter
WPG_0155	ENOG4105EE5	Membrane protein terC
WPG_0156	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
WPG_0160	ENOG4107T8Q	Glycosyl transferase (Group 1
WPG_0162	ENOG4105CGN	Glycosyl transferase (Group 1
WPG_0168	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
WPG_0169	ENOG4107SE4	UDP-N-acetylglucosamine 2-epimerase
WPG_0170	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
WPG_0171	ENOG4105D2T	synthase
WPG_0176	ENOG4105K64	Glycosyl transferase, family 2
WPG_0178	ENOG4105CMR	udp-glucose 4-epimerase
WPG_0182	ENOG4105EY8	ABC transporter
WPG_0184	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
WPG_0186	ENOG4107QQG	Dehydrogenase
WPG_0187	ENOG4105D3Q	Sugar transferase
WPG_0190	ENOG4105C5H	ABC transporter
WPG_0192	ENOG4105C19	ABC transporter
WPG_0196	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
WPG_0199	ENOG4105C34	Pseudouridine synthase
WPG_0209	ENOG4105EMN	RNA polymerase sigma factor
WPG_0211	ENOG4105DJT	lAO AO transport system ATPase
WPG_0212	ENOG4105CKK	Glycosyl transferase, family 2
WPG_0213	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
WPG_0217	ENOG4107QI1	Mate efflux family protein
WPG_0218	ENOG4105EA8	2-Nitropropane dioxygenase
WPG_0220	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
WPG_0224	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
WPG_0225	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
WPG_0228	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
WPG_0230	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
WPG_0232	ENOG4105E9K	Isocitrate dehydrogenase
WPG_0235	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
WPG_0237	ENOG4105C22	threonyL-tRNA synthetase
WPG_0238	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
WPG_0239	ENOG4105VJV	50s ribosomal protein L35
WPG_0240	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
WPG_0241	ENOG4108Q35	Adenylate
WPG_0244	ENOG4105DSF	transport protein
WPG_0246	ENOG4105CDU	Replicative dna helicase
WPG_0247	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
WPG_0250	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
WPG_0251	ENOG4108HHA	Transketolase
WPG_0253	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
WPG_0255	ENOG4105CIN	aminoacyl-histidine dipeptidase
WPG_0257	ENOG4105CD3	dihydroorotase
WPG_0262	ENOG4108RWN	rrna methyltransferase
WPG_0263	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
WPG_0266	ENOG4105CA0	peroxidase
WPG_0267	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
WPG_0269	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
WPG_0271	ENOG4105C8Y	Acetylornithine aminotransferase
WPG_0275	ENOG4105E2X	shikimate dehydrogenase
WPG_0278	ENOG4105DXN	mazG family
WPG_0280	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
WPG_0281	ENOG4107ZNS	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
WPG_0282	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
WPG_0284	ENOG4105K64	Glycosyl transferase, family 2
WPG_0285	ENOG4107R51	Glycosyl transferase, family 2
WPG_0286	ENOG4106WTF	Glycosyl transferase, family 2
WPG_0292	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
WPG_0293	ENOG4105KY5	gCN5-related N-acetyltransferase
WPG_0294	ENOG4107SF2	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
WPG_0297	ENOG4105CJ1	ABC, transporter
WPG_0307	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
WPG_0311	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
WPG_0313	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
WPG_0318	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
WPG_0326	ENOG4105CSR	polyphosphate kinase 2
WPG_0327	ENOG4108WS4	fmn reductase
WPG_0330	ENOG4105EGS	Mechanosensitive ion channel
WPG_0331	ENOG4105RHA	ABC transporter, permease
WPG_0332	ENOG4108IUX	(ABC) transporter
WPG_0333	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
WPG_0334	ENOG4107XPB	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WPG_0338	ENOG4105CM2	brancheD-chain amino acid aminotransferase
WPG_0340	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
WPG_0341	ENOG4105ECP	epimerase
WPG_0347	ENOG41083GQ	Protein CrcB homolog
WPG_0355	ENOG4108AEY	RNA polymerase sigma factor
WPG_0356	ENOG4105D5P	Methylmalonyl-coA mutase
WPG_0361	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
WPG_0362	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
WPG_0363	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
WPG_0364	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
WPG_0371	ENOG4107R5B	glutamine synthetase
WPG_0377	ENOG4108K8S	endonuclease I
WPG_0381	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
WPG_0393	ENOG4105CEY	Amp-dependent synthetase and ligase
WPG_0394	ENOG4107YAK	holo-(acyl carrier protein) synthase 2
WPG_0395	ENOG41069AG	Ankyrin repeat
WPG_0412	ENOG4108VCT	Sulfite exporter TauE/SafE
WPG_0413	ENOG4105C5X	domain protein
WPG_0416	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
WPG_0417	ENOG4105CP7	Triose-phosphate isomerase
WPG_0421	ENOG4105EEI	dihydropteroate synthase
WPG_0426	ENOG4105BZ1	(ABC) transporter
WPG_0427	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
WPG_0430	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
WPG_0431	ENOG4105RA3	Binds directly to 16S ribosomal RNA (By similarity)
WPG_0432	ENOG4107R1M	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity)
WPG_0437	ENOG4105EUJ	GTP cyclohydrolase i
WPG_0438	ENOG4105C8N	cysteinyl-tRNA synthetase
WPG_0439	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
WPG_0440	ENOG4107QZC	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
WPG_0443	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
WPG_0446	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
WPG_0448	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
WPG_0452	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
WPG_0456	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
WPG_0457	ENOG4106IPI	cyclase, family
WPG_0458	ENOG4105CAQ	asparagine synthetase
WPG_0460	ENOG4105CAQ	asparagine synthetase
WPG_0466	ENOG4108Q9V	regulatoR
WPG_0468	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
WPG_0469	ENOG4105KME	endoribonuclease L-psp
WPG_0470	ENOG4105D7A	ATP-binding protein
WPG_0472	ENOG4108Z2K	Cupin 2, conserved barrel domain protein
WPG_0474	ENOG4105FE9	pseudouridine synthase
WPG_0483	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
WPG_0487	ENOG4108S3W	Anti-feci sigma factor, fecr
WPG_0489	ENOG4108YYS	metal-dependent hydrolase (By similarity)
WPG_0491	ENOG4105C75	arginyL-tRNA synthetase
WPG_0492	ENOG4106FKC	arabinogalactan endo-1,4-beta-galactosidase
WPG_0493	ENOG4105BZU	Histidine kinase
WPG_0494	ENOG4105J0A	Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity)
WPG_0498	ENOG41062IR	nudix hydrolase
WPG_0499	ENOG4107RIV	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
WPG_0501	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
WPG_0502	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
WPG_0503	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
WPG_0505	ENOG4105KNE	Phosphatidate cytidylyltransferase
WPG_0506	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
WPG_0510	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
WPG_0511	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
WPG_0513	ENOG4108ZT0	50S ribosomal protein l17
WPG_0514	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
WPG_0515	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
WPG_0516	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
WPG_0517	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WPG_0518	ENOG410864M	50S ribosomal protein L36
WPG_0519	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
WPG_0520	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
WPG_0521	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
WPG_0522	ENOG41084HK	50S ribosomal protein L30
WPG_0523	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
WPG_0524	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
WPG_0525	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
WPG_0526	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
WPG_0527	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
WPG_0528	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WPG_0529	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
WPG_0530	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
WPG_0531	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
WPG_0532	ENOG4105WNB	50s ribosomal protein l29
WPG_0533	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
WPG_0534	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
WPG_0535	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
WPG_0536	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
WPG_0537	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WPG_0538	ENOG41082S5	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
WPG_0539	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
WPG_0540	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
WPG_0541	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
WPG_0542	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
WPG_0543	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
WPG_0544	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
WPG_0546	ENOG4105C27	TonB-dependent Receptor Plug
WPG_0548	ENOG4105C2N	RNA methyltransferase TrmH family group 3
WPG_0550	ENOG4105D1H	recombination factor protein RarA
WPG_0555	ENOG4105W5Q	DNA repair protein (RadC
WPG_0566	ENOG4105DFU	Cell wall formation (By similarity)
WPG_0570	ENOG4108JJA	ABC, transporter
WPG_0580	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WPG_0581	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
WPG_0582	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
WPG_0583	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
WPG_0584	ENOG4105DGW	oligopeptidase A
WPG_0592	ENOG4105ECP	epimerase
WPG_0596	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WPG_0597	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
WPG_0599	ENOG4107R8N	Glycosyl transferase, family 2
WPG_0602	ENOG4105DHJ	ABC, transporter
WPG_0606	ENOG4105CP2	von willebrand factor, type a
WPG_0610	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
WPG_0611	ENOG4105CHR	reductase
WPG_0615	ENOG4105C7S	Dehydrogenase
WPG_0617	ENOG4105KG3	cytidine deaminase
WPG_0620	ENOG4105E6M	Sulphatase-modifying factor protein
WPG_0621	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
WPG_0622	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
WPG_0624	ENOG4109015	Biopolymer transport protein exbD tolR
WPG_0625	ENOG4105M8K	biopolymer transport protein
WPG_0626	ENOG4105DN9	Na H antiporter
WPG_0629	ENOG4105C1G	acyl-Coa dehydrogenase
WPG_0630	ENOG4107QUV	Domain protein
WPG_0636	ENOG4105C27	TonB-dependent Receptor Plug
WPG_0637	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
WPG_0643	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
WPG_0646	ENOG4105WH1	Two component transcriptional regulator luxr family
WPG_0649	ENOG4105CRK	lysyL-tRNA synthetase
WPG_0663	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
WPG_0665	ENOG4105K6H	D-cysteine desulfhydrase
WPG_0668	ENOG4105CGP	Urocanate hydratase
WPG_0670	ENOG4105CHH	sulfate transporter
WPG_0671	ENOG4105VEQ	Cold shock protein
WPG_0672	ENOG4105FFC	UPF0187 protein
WPG_0673	ENOG4105CPP	Dehydrogenase, E1 component
WPG_0674	ENOG4105CM2	brancheD-chain amino acid aminotransferase
WPG_0675	ENOG4105C7S	Dehydrogenase
WPG_0676	ENOG4105J0Q	Transcriptional regulator
WPG_0679	ENOG4105DXM	phenylacetic acid degradation protein
WPG_0680	ENOG4105CHU	acetyl-coa acetyltransferase
WPG_0682	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
WPG_0684	ENOG4108UKI	Enoyl-CoA hydratase
WPG_0685	ENOG4108ZA2	phenylacetate-CoA oxygenase PaaJ subunit
WPG_0686	ENOG4105D9S	phenylacetate-CoA oxygenase PaaI subunit
WPG_0687	ENOG4105N76	Phenylacetate-CoA oxygenase, subunit
WPG_0688	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
WPG_0689	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
WPG_0691	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
WPG_0698	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
WPG_0699	ENOG4105WH1	Two component transcriptional regulator luxr family
WPG_0700	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
WPG_0706	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
WPG_0707	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
WPG_0708	ENOG4107S18	3-phosphoshikimate 1-carboxyvinyltransferase
WPG_0713	ENOG4105S2T	inner membrane protein YbcI
WPG_0714	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
WPG_0715	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
WPG_0718	ENOG410624X	efflux transporter, rnd family, mfp subunit
WPG_0722	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
WPG_0724	ENOG4105CHM	Aminotransferase
WPG_0726	ENOG4105DA5	(ABC) transporter
WPG_0729	ENOG4107Z7P	Ferredoxin
WPG_0730	ENOG4105CAY	ferredoxin--nadp reductase
WPG_0731	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
WPG_0732	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
WPG_0733	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
WPG_0736	ENOG4107YXA	Transcriptional regulator, BadM Rrf2 family
WPG_0740	ENOG4105C28	cystathionine
WPG_0741	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
WPG_0753	ENOG4105ZMH	deoxynucleoside kinase
WPG_0759	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
WPG_0760	ENOG4105F0N	pyrophosphate phospho-hydrolase
WPG_0765	ENOG4105CPP	Dehydrogenase, E1 component
WPG_0766	ENOG4105BZJ	Electron transfer flavoprotein
WPG_0767	ENOG4105C10	Electron transfer flavoprotein
WPG_0769	ENOG4105D9N	nucleoside
WPG_0770	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
WPG_0772	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
WPG_0774	ENOG4105CJ1	ABC, transporter
WPG_0777	ENOG4105DZ0	fad dependent oxidoreductase
WPG_0778	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
WPG_0779	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
WPG_0780	ENOG4105CMR	udp-glucose 4-epimerase
WPG_0781	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
WPG_0785	ENOG4105C7Z	Conserved Protein
WPG_0799	ENOG4105C27	TonB-dependent Receptor Plug
WPG_0809	ENOG4107B57	rieske 2fe-2S domain-containing protein
WPG_0812	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
WPG_0813	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
WPG_0815	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
WPG_0816	ENOG4108IAJ	Nad-dependent epimerase dehydratase
WPG_0817	ENOG4108RYC	glycosyltransferase
WPG_0820	ENOG4107T8Q	Glycosyl transferase (Group 1
WPG_0821	ENOG4105ER6	polysaccharide biosynthesis protein
WPG_0823	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
WPG_0828	ENOG4107TY6	Acylneuraminate cytidylyltransferase
WPG_0830	ENOG4108MK9	spermidine N(1)-acetyltransferase
WPG_0831	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
WPG_0832	ENOG4105C5E	polysaccharide biosynthesis protein
WPG_0833	ENOG4105ESV	Glycosyl transferase, family 4
WPG_0834	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
WPG_0840	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
WPG_0841	ENOG41083X6	30S ribosomal protein S21
WPG_0846	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
WPG_0847	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
WPG_0848	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
WPG_0849	ENOG41086DT	Membrane protein of unknown function
WPG_0851	ENOG4105EV9	Alpha Beta Hydrolase
WPG_0852	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
WPG_0854	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
WPG_0856	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
WPG_0860	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
WPG_0862	ENOG4108Z0R	Transferase
WPG_0863	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
WPG_0864	ENOG4108HRK	Histidine kinase
WPG_0870	ENOG41083MR	nifu domain-containing protein
WPG_0872	ENOG4105D64	Mechanosensitive ion channel
WPG_0873	ENOG41072GX	Peptidase M22 Glycoprotease
WPG_0874	ENOG410624X	efflux transporter, rnd family, mfp subunit
WPG_0876	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
WPG_0877	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
WPG_0878	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
WPG_0879	ENOG4105C19	ABC transporter
WPG_0881	ENOG4108SJC	Membrane
WPG_0882	ENOG4108KF3	Electron transport protein SCO1 SenC
WPG_0886	ENOG4107R3R	Cytochrome o ubiquinol oxidase subunit III
WPG_0887	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
WPG_0895	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
WPG_0897	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
WPG_0898	ENOG4105C6K	Malic enzyme
WPG_0900	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
WPG_0901	ENOG4105CA0	peroxidase
WPG_0902	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
WPG_0903	ENOG4105BZ9	Cytochrome C oxidase, subunit I
WPG_0904	ENOG4105E2S	oxidase) subunit II
WPG_0908	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
WPG_0909	ENOG4107SFQ	iron-sulfur binding
WPG_0913	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
WPG_0914	ENOG4105CHV	Transcription elongation factor NusA
WPG_0915	ENOG41090IP	Required for maturation of 30S ribosomal subunits (By similarity)
WPG_0916	ENOG4107YZX	Universal stress protein
WPG_0919	ENOG4108ZJ4	polysaccharide deacetylase
WPG_0920	ENOG4105K63	Thioredoxin
WPG_0923	ENOG4106N3A	copper homeostasis protein cutc
WPG_0924	ENOG4105E2D	ec 3.2.1.52
WPG_0927	ENOG4105CWX	Alpha-1,2-mannosidase
WPG_0931	ENOG4105ENE	Histidine kinase
WPG_0932	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
WPG_0938	ENOG4108DIG	cyanophycin synthetase
WPG_0941	ENOG4105D44	asparaginase
WPG_0945	ENOG4105C2M	dna polymerase I
WPG_0954	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
WPG_0958	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
WPG_0965	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
WPG_0972	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
WPG_0973	ENOG4108UJD	30S ribosomal protein S9
WPG_0974	ENOG4105CE9	30S ribosomal protein S2
WPG_0975	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
WPG_0976	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
WPG_0977	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
WPG_0980	ENOG4105C5S	asparaginyl-tRNA synthetase
WPG_0981	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
WPG_0988	ENOG4105HDK	L-asparaginase
WPG_0989	ENOG4105F8V	Hydrolase, tatD family
WPG_0992	ENOG4105C7S	Dehydrogenase
WPG_0993	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
WPG_0996	ENOG4105EAH	synthase
WPG_0997	ENOG4108IG5	Transcriptional regulator
WPG_1001	ENOG4105BZS	acriflavin resistance protein
WPG_1002	ENOG4105C9M	aspartyl-trna synthetase
WPG_1007	ENOG4105VEQ	Cold shock protein
WPG_1008	ENOG4108Z6B	deaminase
WPG_1011	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
WPG_1014	ENOG4105C27	TonB-dependent Receptor Plug
WPG_1020	ENOG4107QX9	Thiol disulfide interChange protein
WPG_1022	ENOG4105DY9	regulatoR
WPG_1023	ENOG4107QYD	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
WPG_1024	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
WPG_1033	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
WPG_1036	ENOG4105CN1	protease
WPG_1039	ENOG4105C3R	Methionine synthase
WPG_1040	ENOG41061CK	Antibiotic biosynthesis monooxygenase
WPG_1041	ENOG4105C3R	Methionine synthase
WPG_1042	ENOG4105SYT	Methylenetetrahydrofolate reductase
WPG_1047	ENOG4105D49	3-dehydroquinate synthase
WPG_1055	ENOG4107KJX	Transcriptional regulator
WPG_1056	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
WPG_1057	ENOG4107ZQV	short-chain dehydrogenase reductase
WPG_1060	ENOG4105DPW	Major facilitator superfamily MFS_1
WPG_1061	ENOG4107YCY	Transcriptional regulator
WPG_1065	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
WPG_1074	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
WPG_1075	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
WPG_1076	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
WPG_1077	ENOG4105DTN	riboflavin biosynthesis protein ribF
WPG_1079	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
WPG_1083	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
WPG_1084	ENOG4105CJW	magnesium transporter
WPG_1087	ENOG4108JQ1	Dehydrogenase
WPG_1089	ENOG4105WH1	Two component transcriptional regulator luxr family
WPG_1099	ENOG4105CFH	Aspartokinase
WPG_1101	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WPG_1103	ENOG4108JA2	transcriptioN-repair coupling factor
WPG_1108	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
WPG_1113	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
WPG_1117	ENOG4105CHH	sulfate transporter
WPG_1124	ENOG4107QVM	von Willebrand factor, type A
WPG_1128	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
WPG_1130	ENOG4107QM2	Aldo Keto reductase
WPG_1131	ENOG4105EMU	Dehydrogenase
WPG_1137	ENOG4105CDV	Ompa motb domain protein
WPG_1140	ENOG4105C26	Dehydrogenase
WPG_1141	ENOG4105D44	asparaginase
WPG_1143	ENOG4107SP2	The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity
WPG_1149	ENOG4105KAC	Antibiotic biosynthesis monooxygenase
WPG_1152	ENOG4108JQB	penicillin-binding protein 1C
WPG_1163	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
WPG_1164	ENOG4105K46	50S ribosomal protein l27
WPG_1165	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
WPG_1166	ENOG4105IIU	Aminopeptidase
WPG_1167	ENOG4105E33	succinate dehydrogenase
WPG_1176	ENOG4107RAQ	aminopeptidase
WPG_1178	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
WPG_1180	ENOG4108MUZ	hydrolase
WPG_1183	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
WPG_1186	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
WPG_1191	ENOG4105C9B	Cysteine desulfurase
WPG_1193	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
WPG_1194	ENOG4105VG1	fes assembly suf system protein
WPG_1197	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
WPG_1201	ENOG4105UYK	outer membrane protein a
WPG_1204	ENOG41080ZE	Adenylate cyclase
WPG_1207	ENOG4105CA9	Pyruvate kinase
WPG_1209	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
WPG_1210	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
WPG_1211	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
WPG_1212	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
WPG_1213	ENOG4108B1Q	Ribonuclease
WPG_1215	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
WPG_1216	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
WPG_1217	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
WPG_1218	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
WPG_1219	ENOG4105UYK	outer membrane protein a
WPG_1225	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
WPG_1226	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
WPG_1227	ENOG4105ENH	Sulfatase
WPG_1229	ENOG4106VK6	Flagellar motor protein
WPG_1231	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
WPG_1233	ENOG4108UKZ	OsmC family
WPG_1235	ENOG4108RG0	uracil-dna glycosylase
WPG_1239	ENOG4107T8J	thymidine kinase
WPG_1240	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
WPG_1241	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
WPG_1242	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
WPG_1248	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
WPG_1251	ENOG4108IYU	L-aspartate oxidase
WPG_1252	ENOG4105IIU	Aminopeptidase
WPG_1253	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
WPG_1254	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
WPG_1255	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
WPG_1256	ENOG4105WXV	50S ribosomal protein L32
WPG_1258	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
WPG_1259	ENOG4108R6K	riboflavin synthase, subunit alpha
WPG_1261	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
WPG_1262	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
WPG_1263	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
WPG_1265	ENOG4108JUA	Transcriptional regulator
WPG_1268	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
WPG_1273	ENOG4105E2D	ec 3.2.1.52
WPG_1275	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
WPG_1277	ENOG4105C27	TonB-dependent Receptor Plug
WPG_1278	ENOG4108HRK	Histidine kinase
WPG_1279	ENOG4105DY9	regulatoR
WPG_1283	ENOG4108ZVT	methylmalonyl-coA epimerase
WPG_1284	ENOG4105H4N	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
WPG_1285	ENOG4105D60	lipoprotein releasing system transmembrane protein
WPG_1286	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
WPG_1291	ENOG4108MR6	WD40-like Beta Propeller Repeat
WPG_1293	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
WPG_1295	ENOG4105WH1	Two component transcriptional regulator luxr family
WPG_1299	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
WPG_1300	ENOG4105C8F	Beta-lactamase domain protein
WPG_1303	ENOG4105WG6	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
WPG_1304	ENOG4105CN1	protease
WPG_1306	ENOG4107YB6	acetyltransferase, (GNAT) family
WPG_1307	ENOG4108YZG	isomerase
WPG_1311	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
WPG_1312	ENOG4105K8R	UPF0145 protein
WPG_1319	ENOG4105CX6	glutaminyL-tRNA synthetase
WPG_1325	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
WPG_1326	ENOG4105EEF	Alkane 1-monooxygenase
WPG_1328	ENOG41080AX	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
WPG_1329	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
WPG_1332	ENOG4107QRG	dna polymerase iii
WPG_1333	ENOG4105BZA	Phosphoglycerate kinase
WPG_1334	ENOG4105E9H	Lytic Murein transglycosylase
WPG_1336	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
WPG_1342	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
WPG_1344	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
WPG_1359	ENOG4105C12	Phosphoribosylglycinamide synthetase
WPG_1362	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
WPG_1365	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
WPG_1376	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
WPG_1377	ENOG4105VHG	atp synthase
WPG_1378	ENOG4107Z65	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
WPG_1379	ENOG4107Z4P	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
WPG_1380	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
WPG_1381	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
WPG_1385	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
WPG_1386	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
WPG_1391	ENOG4105NAU	thioesterase Superfamily protein
WPG_1394	ENOG4105C31	Tryptophanyl-tRNA synthetase
WPG_1399	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
WPG_1403	ENOG4105MA4	psp1 domain protein
WPG_1404	ENOG410647Z	gliding motility-associated lipoprotein GldH
WPG_1405	ENOG4108JQC	penicillin-binding protein 1A
WPG_1406	ENOG4107QP7	CoA-transferase subunit A
WPG_1418	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
WPG_1426	ENOG4105D52	delta-aminolevulinic acid dehydratase
WPG_1427	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
WPG_1431	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
WPG_1436	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
WPG_1438	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
WPG_1439	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
WPG_1443	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
WPG_1448	ENOG4105E39	Enoyl-CoA hydratase
WPG_1449	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
WPG_1452	ENOG4108R6W	Transcriptional regulator, ARAC family
WPG_1457	ENOG4108Y6J	UPF0403 protein
WPG_1458	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
WPG_1461	ENOG4107RBD	ABC, transporter
WPG_1462	ENOG4107RPQ	ABC transporter
WPG_1464	ENOG4105DIK	(ABC) transporter
WPG_1465	ENOG4105DSE	periplasmic solute binding protein
WPG_1466	ENOG4105D05	Receptor
WPG_1470	ENOG4105CE1	Ferrous iron transport protein b
WPG_1472	ENOG4108KF3	Electron transport protein SCO1 SenC
WPG_1477	ENOG4105EXW	epimerase dehydratase
WPG_1479	ENOG4105C9K	Endothelin-converting enzyme 1
WPG_1482	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
WPG_1485	ENOG4108UUM	single-stranded DNA-binding protein
WPG_1491	ENOG41063TF	transcriptional regulator (AraC
WPG_1494	ENOG41090A1	ferritin
WPG_1496	ENOG410756H	nucleotidyltransferase
WPG_1501	ENOG4105E0Y	RtcB Protein
WPG_1503	ENOG4108S2Y	peptide Chain Release factor
WPG_1518	ENOG4105DGU	Histone deacetylase
WPG_1520	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
WPG_1523	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
WPG_1525	ENOG4105FQP	Beta-lactamase
WPG_1527	ENOG41080R2	UPF0102 protein
WPG_1528	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
WPG_1529	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
WPG_1530	ENOG4105DSJ	YicC domain protein
WPG_1536	ENOG4105EEQ	Na H antiporter
WPG_1538	ENOG4105C28	cystathionine
WPG_1540	ENOG4107R37	Glutamate dehydrogenase
WPG_1542	ENOG41060VI	Involved in DNA repair and RecF pathway recombination (By similarity)
WPG_1543	ENOG4107ENK	receptor
WPG_1545	ENOG410902V	Modulates RecA activity (By similarity)
WPG_1548	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
WPG_1555	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
WPG_1556	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
WPG_1558	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
WPG_1563	ENOG4105VMP	Transcriptional regulator
WPG_1564	ENOG4108RAV	Conserved protein
WPG_1565	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
WPG_1566	ENOG4105C0B	DNA polymerase III (alpha subunit)
WPG_1568	ENOG4105DY9	regulatoR
WPG_1569	ENOG4108HRK	Histidine kinase
WPG_1571	ENOG4105CK5	oxidoreductase
WPG_1572	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
WPG_1573	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
WPG_1575	ENOG4105C27	TonB-dependent Receptor Plug
WPG_1576	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
WPG_1578	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
WPG_1579	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
WPG_1580	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
WPG_1585	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
WPG_1588	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
WPG_1590	ENOG4107T7F	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
WPG_1591	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
WPG_1593	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
WPG_1594	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
WPG_1595	ENOG4105D78	K07001 NTE family protein
WPG_1596	ENOG4105F1J	Homogentisate 1,2-dioxygenase
WPG_1598	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
WPG_1600	ENOG4105HJ8	Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity)
WPG_1602	ENOG4107QP8	phosphohexose isomerase
WPG_1603	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
WPG_1606	ENOG4105C37	(CBS) domain
WPG_1607	ENOG4108UUM	single-stranded DNA-binding protein
WPG_1608	ENOG4105CEN	a g-specific adenine glycosylase
WPG_1609	ENOG4105K70	DNA-binding protein
WPG_1610	ENOG4105C03	ribonuclease
WPG_1611	ENOG4105CPC	Aldo Keto reductase
WPG_1613	ENOG4105CGK	Exodeoxyribonuclease III
WPG_1619	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
WPG_1621	ENOG4105MJ2	Competence protein
WPG_1625	ENOG4105CHM	Aminotransferase
WPG_1633	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
WPG_1635	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
WPG_1640	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
WPG_1643	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
WPG_1644	ENOG4107ZUX	Histidine triad (HIT) protein
WPG_1645	ENOG4105BZU	Histidine kinase
WPG_1646	ENOG4105EW6	flavin reductase domain protein, FMN-binding
WPG_1648	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
WPG_1651	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
WPG_1654	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
WPG_1655	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
WPG_1661	ENOG4107RJ9	Cell division protein FtsX
WPG_1662	ENOG4105C8T	Leucyl-tRNA synthetase
WPG_1663	ENOG4105W3H	MtN3 and saliva related transmembrane protein
WPG_1664	ENOG4105DCF	alanine dehydrogenase
WPG_1667	ENOG4108VVK	transcriptional Regulator, AsnC
WPG_1669	ENOG4105M08	Membrane
WPG_1670	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
WPG_1673	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
WPG_1674	ENOG4105CD3	dihydroorotase
WPG_1676	ENOG4105ECP	epimerase
WPG_1677	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
WPG_1681	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
WPG_1682	ENOG4105BZU	Histidine kinase
WPG_1684	ENOG4107UGT	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
WPG_1688	ENOG41083MR	nifu domain-containing protein
WPG_1689	ENOG4105CAY	ferredoxin--nadp reductase
WPG_1690	ENOG4108ZIT	Ferredoxin, 2FE-2S
WPG_1694	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
WPG_1695	ENOG4107YAY	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
WPG_1696	ENOG4105K5M	30s ribosomal protein S16
WPG_1698	ENOG4105C0B	DNA polymerase III (alpha subunit)
WPG_1702	ENOG4105JSC	dimethylmenaquinone methyltransferase
WPG_1705	ENOG4105BZU	Histidine kinase
WPG_1714	ENOG4105CKK	Glycosyl transferase, family 2
WPG_1717	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
WPG_1719	ENOG4105CSA	Coproporphyrinogen iii oxidase
WPG_1723	ENOG4105MSB	protein, conserved in bacteria
WPG_1727	ENOG4105BZU	Histidine kinase
WPG_1729	ENOG4105BZU	Histidine kinase
WPG_1731	ENOG4105DY9	regulatoR
WPG_1732	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
WPG_1738	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
WPG_1740	ENOG4105E2K	Glycosyl transferase (Group 1
WPG_1742	ENOG4108UW5	maltose o-acetyltransferase
WPG_1753	ENOG4105DG6	mannose-6-phosphate isomerase
WPG_1754	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
WPG_1761	ENOG4107VAM	peptidase, m28
WPG_1766	ENOG4108IUM	Glycogen debranching enzyme
WPG_1769	ENOG4105C27	TonB-dependent Receptor Plug
WPG_1770	ENOG4105ETE	Transcriptional regulator (LacI family
WPG_1772	ENOG4107URF	beta-phospho-glucomutase
WPG_1774	ENOG4108IUK	alpha amylase, catalytic
WPG_1775	ENOG4108SA1	esterase
WPG_1776	ENOG4105CJQ	hydrolase, family 31
WPG_1778	ENOG4107T9C	Alpha amylase catalytic region
WPG_1782	ENOG4105CNG	UPF0061 protein
WPG_1785	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
WPG_1789	ENOG4105CBX	hi0933 family
WPG_1796	ENOG4105FE9	pseudouridine synthase
WPG_1809	ENOG4105CND	Glycosyl transferase, family 2
WPG_1814	ENOG4108IFG	nitrite reductase, (NAD(P)H)
WPG_1825	ENOG4105CKK	Glycosyl transferase, family 2
WPG_1829	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
WPG_1835	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
WPG_1839	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
WPG_1841	ENOG4107Y2X	deaminase
WPG_1842	ENOG4107QMZ	Dehydrogenase
WPG_1843	ENOG4105CTU	Proline racemase
WPG_1845	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
WPG_1847	ENOG4105DWV	Homoserine O-trans-acetylase
WPG_1850	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
WPG_1851	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
WPG_1852	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
WPG_1853	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
WPG_1854	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
WPG_1856	ENOG4108YZA	Nitrogen regulatory protein pii
WPG_1861	ENOG4105CH7	arginosuccinase
WPG_1863	ENOG4107T6X	nag kinase
WPG_1864	ENOG4107REN	Carbamoyltransferase
WPG_1865	ENOG4105C8Y	Acetylornithine aminotransferase
WPG_1866	ENOG41063V1	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
WPG_1867	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
WPG_1868	ENOG4105CDH	Citrulline--aspartate ligase
WPG_1870	ENOG4105C26	Dehydrogenase
WPG_1871	ENOG4105C7B	Threonine dehydratase
WPG_1872	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
WPG_1874	ENOG4105C7K	acetolactate synthase
WPG_1875	ENOG4105C01	Dihydroxy-acid dehydratase
WPG_1876	ENOG4107QNK	)-transporter
WPG_1878	ENOG4105ETE	Transcriptional regulator (LacI family
WPG_1879	ENOG4105ETE	Transcriptional regulator (LacI family
WPG_1880	ENOG4105C27	TonB-dependent Receptor Plug
WPG_1887	ENOG4105DBI	uridine monophosphokinase
WPG_1891	ENOG4106UW1	Major Facilitator superfamily
WPG_1892	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
WPG_1893	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
WPG_1894	ENOG41090JD	Blue (Type 1) copper domain protein
WPG_1900	ENOG4105EAA	nucleoside
WPG_1904	ENOG4105CG3	alpha amylase, catalytic region
WPG_1905	ENOG4107RUZ	Sss sodium solute transporter superfamily
WPG_1906	ENOG4107RK0	Sucrose phosphorylase
WPG_1907	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
WPG_1912	ENOG4105C37	(CBS) domain
WPG_1915	ENOG4107EEU	hydroxymethylglutaryL-CoA reductase
WPG_1916	ENOG4105C5Z	peptidase
WPG_1917	ENOG4105DUX	Transporter
WPG_1918	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
WPG_1919	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
WPG_1920	ENOG4108QBX	(LipO)protein
WPG_1921	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
WPG_1923	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
WPG_1924	ENOG4105CN1	protease
WPG_1925	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
WPG_1926	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
WPG_1928	ENOG4107YM1	mraZ protein
WPG_1929	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
WPG_1931	ENOG4105CJN	penicillin-binding protein
WPG_1932	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
WPG_1933	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
WPG_1934	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
WPG_1935	ENOG4105CNI	cell division protein FtsW
WPG_1936	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
WPG_1937	ENOG4105DFU	Cell wall formation (By similarity)
WPG_1939	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
WPG_1940	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
WPG_1941	ENOG4105KTH	gatB Yqey
WPG_1948	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
WPG_1949	ENOG4105C30	Nad-dependent epimerase dehydratase
WPG_1951	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
WPG_1952	ENOG4105C11	sulfate adenylyltransferase), subunit 2
WPG_1954	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
WPG_1955	ENOG4105BZ1	(ABC) transporter
WPG_1959	ENOG4105K64	Glycosyl transferase, family 2
WPG_1960	ENOG4108UW5	maltose o-acetyltransferase
WPG_1962	ENOG4105K64	Glycosyl transferase, family 2
WPG_1967	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
WPG_1975	ENOG4107QRS	glycosyltransferase group 2 family protein
WPG_1976	ENOG4105ESV	Glycosyl transferase, family 4
WPG_1978	ENOG4107YJ4	chain length determinant protein
WPG_1980	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
WPG_1985	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
WPG_1986	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
WPG_1989	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
WPG_1990	ENOG4105D2N	Aldolase
WPG_1994	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
WPG_1995	ENOG4105C1A	potassium transporter peripheral membrane
WPG_1996	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
WPG_2000	ENOG4105CHM	Aminotransferase
WPG_2002	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
WPG_2006	ENOG4107ZT5	Thiol disulfide interchange protein
WPG_2009	ENOG4105C26	Dehydrogenase
WPG_2011	ENOG4105NWN	ApaG protein
WPG_2012	ENOG4105DY8	decarboxylase
WPG_2015	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
WPG_2016	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
WPG_2017	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
WPG_2018	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
WPG_2021	ENOG4105C8P	)-transporter
WPG_2024	ENOG4105CJ2	(LipO)protein
WPG_2028	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
WPG_2030	ENOG4108K0D	peptidase, M48
WPG_2032	ENOG4105EQ6	Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity)
WPG_2037	ENOG4108CSZ	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
WPG_2041	ENOG4105C3W	Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity)
WPG_2042	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
WPG_2050	ENOG4107RQD	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
WPG_2051	ENOG4105CKY	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
WPG_2055	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
WPG_2058	ENOG4105EGD	dinuclear metal center protein, YbgI family
WPG_2059	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
WPG_2060	ENOG4105BZU	Histidine kinase
WPG_2062	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
WPG_2064	ENOG4105K3M	)-transporter
WPG_2068	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
WPG_2070	ENOG4105K6V	RNA polymerase
WPG_2071	ENOG4107R0I	Cell wall formation (By similarity)
WPG_2072	ENOG4105CHM	Aminotransferase
WPG_2075	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
WPG_2076	ENOG4105C6Z	Gluconate
WPG_2077	ENOG4105CNI	cell division protein FtsW
WPG_2078	ENOG4105CJN	penicillin-binding protein
WPG_2081	ENOG4105DFF	Rod shape-determining protein mreb
WPG_2084	ENOG4105DC1	bifunctional purine biosynthesis protein purh
WPG_2095	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
WPG_2096	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
WPG_2101	ENOG4108JUA	Transcriptional regulator
WPG_2103	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
WPG_2108	ENOG4105E6M	Sulphatase-modifying factor protein
WPG_2112	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
WPG_2114	ENOG4105C5H	ABC transporter
WPG_2129	ENOG4105EFZ	amidohydrolase
WPG_2132	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
WPG_2155	ENOG4105BZU	Histidine kinase
WPG_2159	ENOG4108RCM	Nitroreductase
WPG_2162	ENOG4105DY9	regulatoR
WPG_2163	ENOG4108HRK	Histidine kinase
WPG_2166	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
WPG_2167	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
WPG_2173	ENOG4105X54	addiction module antidote protein
WPG_2204	ENOG4108A04	Beta-lactamase
WPG_2221	ENOG4107J0C	type IIi
WPG_2222	ENOG4107QMH	DNA methylase
WPG_2229	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
WPG_2231	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
WPG_2234	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
WPG_2243	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
WPG_2246	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
WPG_2247	ENOG4105CPF	Cell wall formation (By similarity)
WPG_2249	ENOG4105C34	Pseudouridine synthase
WPG_2250	ENOG4105D1Q	UPF0246 protein
WPG_2254	ENOG4108KB1	transcriptional regulator, arac family
WPG_2255	ENOG4105C1J	atp-dependent rna helicase
WPG_2257	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
WPG_2264	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
WPG_2265	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
WPG_2266	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
WPG_2267	ENOG4105DK0	Indole-3-glycerol phosphate synthase
WPG_2268	ENOG4108I0Q	anthranilate phosphoribosyltransferase
WPG_2269	ENOG4105DDQ	anthranilate synthase
WPG_2270	ENOG4105CRQ	synthase (Component I)
WPG_2272	ENOG4108V06	Glutathione peroxidase
WPG_2273	ENOG41085GJ	domain protein
WPG_2274	ENOG4105C72	UPF0176 protein
WPG_2279	ENOG4105BZU	Histidine kinase
WPG_2282	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
WPG_2283	ENOG4107RBB	ABC transporter, permease
WPG_2284	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
WPG_2285	ENOG4107RBB	ABC transporter, permease
WPG_2288	ENOG4107RBB	ABC transporter, permease
WPG_2291	ENOG4105C19	ABC transporter
WPG_2300	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
WPG_2301	ENOG4105E0X	reductase
WPG_2309	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
WPG_2311	ENOG4105FQP	Beta-lactamase
WPG_2341	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
WPG_2355	ENOG4107VUZ	
WPG_2380	ENOG4108IXY	short-chain dehydrogenase reductase
WPG_2384	ENOG4108UB4	uncharacterized protein ygjQ
WPG_2391	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
WPG_2394	ENOG4105CI3	gtp-binding protein typa
WPG_2403	ENOG4105EGZ	biosynthesis protein
WPG_2407	ENOG4107XU6	Glycosyl transferase (Group 1
WPG_2411	ENOG4105CAK	Cell division ATP-binding protein ftsE
WPG_2415	ENOG4105EFZ	amidohydrolase
WPG_2420	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
WPG_2422	ENOG4105EHZ	conserved protein UCP016719
WPG_2427	ENOG4105BZU	Histidine kinase
WPG_2430	ENOG4107SVH	Potassium channel protein
WPG_2431	ENOG4105BZG	amino acid carrier protein
WPG_2432	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
WPG_2433	ENOG4105C1G	acyl-Coa dehydrogenase
WPG_2434	ENOG4108HE4	integrase family
WPG_2435	ENOG4105MS2	ribosomal subunit Interface protein
WPG_2436	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
WPG_2439	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
WPG_2440	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
WPG_2441	ENOG4107VNI	ribosomal protein l10
WPG_2442	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
WPG_2443	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
WPG_2444	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
WPG_2450	ENOG4107X35	defense response to bacterium
WPG_2451	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
WPG_2454	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
WPG_2465	ENOG4105F6J	Alpha beta hydrolase fold
WPG_2472	ENOG4105EMN	RNA polymerase sigma factor
WPG_2479	ENOG4105C1J	atp-dependent rna helicase
WPG_2481	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
WPG_2482	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
WPG_2483	ENOG4108RPX	mosc domain containing protein
WPG_2486	ENOG4105CNT	hydrolase family 2
WPG_2487	ENOG4105CNT	hydrolase family 2
WPG_2488	ENOG4105FQP	Beta-lactamase
WPG_2491	ENOG4105FQP	Beta-lactamase
WPG_2493	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
WPG_2494	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
WPG_2501	ENOG4107RJ1	sodium solute
WPG_2503	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
WPG_2511	ENOG4105XDF	Protein of unknown function (DUF1272)
WPG_2518	ENOG4107RZZ	dna polymerase iii epsilon subunit
WPG_2519	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
WPG_2521	ENOG4105CEV	competence damage-inducible protein
WPG_2522	ENOG4105KDC	50s ribosomal protein l28
WPG_2523	ENOG41083ND	50S ribosomal protein L33
WPG_2525	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
WPG_2528	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
WPG_2533	ENOG4107RAN	Peptidase, M16
WPG_2535	ENOG41074B2	UPF0747 protein
WPG_2540	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
WPG_2543	ENOG4105VRT	cytoplasmic protein
WPG_2557	ENOG4105C1G	acyl-Coa dehydrogenase
WPG_2558	ENOG4105CHU	acetyl-coa acetyltransferase
WPG_2560	ENOG4108T3F	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
WPG_2563	ENOG4108ETH	Formylglycinamide ribotide synthetase
WPG_2564	ENOG4108K8S	endonuclease I
WPG_2581	ENOG4105EMN	RNA polymerase sigma factor
WPG_2582	ENOG4105BZ1	(ABC) transporter
WPG_2584	ENOG4105CKK	Glycosyl transferase, family 2
WPG_2586	ENOG41081WG	50s ribosomal protein l31
WPG_2590	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
WPG_2595	ENOG4105VG0	50S ribosomal protein l34
WPG_2598	ENOG4105NAU	thioesterase Superfamily protein
WPG_2599	ENOG4105CGY	Dna recombination protein
WPG_2603	ENOG4105E0A	ABC, transporter
WPG_2604	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
WPG_2607	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
WPG_2611	ENOG4105T65	Membrane-associated protein
WPG_2614	ENOG4107QTF	adenylosuccinate lyase
WPG_2622	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
WPG_2631	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
WPG_2635	ENOG4105EPC	oxidoreductase
WPG_2637	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
WPG_2638	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
WPG_2639	ENOG4107U9T	Pfam:Ribonuclease_BN
WPG_2640	ENOG4108NEV	two component transcriptional regulator, LytTR family
WPG_2641	ENOG4108HRK	Histidine kinase
WPG_2653	ENOG4105C25	Primosomal protein n'
WPG_2654	ENOG4108NEV	two component transcriptional regulator, LytTR family
WPG_2655	ENOG41080B9	Binds together with S18 to 16S ribosomal RNA (By similarity)
WPG_2656	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
WPG_2657	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
WPG_2658	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
WPG_2660	ENOG4107RBB	ABC transporter, permease
WPG_2661	ENOG4105CUT	histidyl-tRNA synthetase
WPG_2666	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
WPG_2667	ENOG4107MM9	BNR Asp-box repeat-containing protein
WPG_2670	ENOG4105F0I	Aminotransferase
WPG_2671	ENOG4108UJU	UPF0301 protein
WPG_2672	ENOG4105K70	DNA-binding protein
WPG_2673	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
WPG_2674	ENOG4105C9U	ATP-dependent DNA helicase RecQ
WPG_2678	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
WPG_2687	ENOG4108V06	Glutathione peroxidase
WPG_2688	ENOG4105CHR	reductase
WPG_2690	ENOG4105EUJ	GTP cyclohydrolase i
WPG_2693	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
WPG_2694	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
WPG_2696	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
WPG_2698	ENOG4105CGD	Nad-dependent epimerase dehydratase
WPG_2702	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
WPG_2705	ENOG41080HT	Transcriptional regulator, arsr family
WPG_2713	ENOG4108Z03	MAF-like protein
WPG_2719	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
WPG_2720	ENOG4105CRE	cytochrome C
WPG_2725	ENOG4105C28	cystathionine
WPG_2726	ENOG4105FJR	Lmbe family
WPG_2727	ENOG4105IIU	Aminopeptidase
WPG_2728	ENOG4105IIU	Aminopeptidase
WPG_2734	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
WPG_2735	ENOG4108RCM	Nitroreductase
WPG_2736	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
WPG_2738	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
WPG_2741	ENOG4105CNU	cell division protein FtsK
WPG_2744	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
WPG_2754	ENOG4105CRW	Short chain fatty acid transporter
WPG_2757	ENOG4108K8S	endonuclease I
WPG_2761	ENOG4105CBC	glutamate synthase
WPG_2769	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
WPG_2770	ENOG4105C2C	drug resistance transporter, Bcr CflA
WPG_2772	ENOG4105BZ1	(ABC) transporter
WPG_2774	ENOG4107QX3	carboxylase
WPG_2775	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
WPG_2777	ENOG4108PNU	Involved in the degradation of specific anti-sigma factors (By similarity)
WPG_2778	ENOG4108ZEY	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
WPG_2780	ENOG4105CN9	Peptidase m42 family protein
WPG_2782	ENOG4108UT2	hemolysin iii
WPG_2789	ENOG4105EWI	Short-chain dehydrogenase reductase Sdr
WPG_2790	ENOG4108RCM	Nitroreductase
WPG_2805	ENOG4105CZH	peptidase
WPG_2809	ENOG4105CKI	cobalamin synthesis protein
WPG_2812	ENOG4105CIG	ABC transporter
WPG_2817	ENOG4108D32	Methyltransferase
WPG_2820	ENOG4105DY9	regulatoR
WPG_2821	ENOG4105C2F	Histidine kinase
WPG_2830	ENOG4105CPP	Dehydrogenase, E1 component
WPG_2833	ENOG4108URH	decarboxylase
WPG_2834	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
WPG_2843	ENOG4107RE3	peptidase, S41
WPG_2844	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
WPG_2846	ENOG4107QKV	phosphomannomutase
WPG_2848	ENOG4105D1S	lipid A biosynthesis
WPG_2850	ENOG4107ZT5	Thiol disulfide interchange protein
WPG_2851	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
WPG_2853	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
WPG_2858	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
WPG_2859	ENOG4105C9A	Phoh family
WPG_2860	ENOG4107QWK	SAICAR synthetase
WPG_2868	ENOG4105EMN	RNA polymerase sigma factor
WPG_2870	ENOG4105C8Y	Acetylornithine aminotransferase
WPG_2876	ENOG4107QI6	Cysteine desulfurase
WPG_2882	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
WPG_2883	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
WPG_2885	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
WPG_2888	ENOG4107QN2	dihydrolipoyl dehydrogenase
WPG_2890	ENOG4105E0X	reductase
WPG_2891	ENOG4107QPH	glycogen) synthase
WPG_2892	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
WPG_2893	ENOG4107S9Q	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
WPG_2894	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
WPG_2895	ENOG4107R91	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
WPG_2898	ENOG4105DEU	major facilitator superfamily
WPG_2905	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
WPG_2906	ENOG4107X35	defense response to bacterium
WPG_2908	ENOG4105CAT	Cytidine monophosphate kinase
WPG_2909	ENOG4108I7Y	domain protein
WPG_2911	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
WPG_2913	ENOG4105CXT	aspartate transcarbamylase
WPG_2915	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
WPG_2917	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
WPG_2925	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
WPG_2931	ENOG4105C6E	dna polymerase iii
WPG_2933	ENOG4106H78	methyltransferase
WPG_2936	ENOG4105C7H	Helicase, RecD TraA family
WPG_2938	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
WPG_2941	ENOG4107RJC	Iron-containing alcohol dehydrogenase
WPG_2949	ENOG4105BZG	amino acid carrier protein
WPG_2951	ENOG4107QN1	sodium solute
WPG_2954	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
WPG_2956	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
WPG_2960	ENOG4107RNH	Outer membrane receptor FepA
WPG_2962	ENOG4105K89	arsenate reductase
WPG_2964	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
WPG_2967	ENOG4105K64	Glycosyl transferase, family 2
WPG_2968	ENOG4105K64	Glycosyl transferase, family 2
WPG_2970	ENOG41080WS	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
WPG_2974	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
WPG_2986	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
WPG_2990	ENOG4105CSM	endonuclease III
WPG_2991	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WPG_2997	ENOG4105CD3	dihydroorotase
WPG_3008	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
WPG_3010	ENOG4105DF6	Fe-S oxidoreductase
WPG_3012	ENOG4105DF6	Fe-S oxidoreductase
WPG_3014	ENOG4105EAC	phosphoserine phosphatase
WPG_3015	ENOG4105D17	glycoside hydrolase, family 3 domain protein
WPG_3016	ENOG4105CPK	Glycosyl transferase (Group 1
WPG_3020	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
WPG_3022	ENOG41090KQ	Glyoxalase Bleomycin resistance protein (Dioxygenase
WPG_3029	ENOG4105NCT	RNA Polymerase
WPG_3033	ENOG4105ED2	Beta-lactamase
WPG_3041	ENOG4105CDY	transcriptional regulatory protein
WPG_3042	ENOG4105KZX	Pterin carbinolamine dehydratase
WPG_3044	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
WPG_3046	ENOG4105CQB	FAD linked oxidase domain protein
WPG_3048	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
WPG_3051	ENOG4105CK2	sodium dicarboxylate symporter
WPG_3052	ENOG4105D7Z	glutathione synthase
WPG_3057	ENOG4105KIR	Thiol-disulfide oxidoreductase dcc
WPG_3058	ENOG4105C98	muts2 protein
WPG_3059	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
WPG_3065	ENOG4105CPP	Dehydrogenase, E1 component
WPG_3074	ENOG4108R99	pseudouridine synthase
WPG_3096	ENOG4105EMN	RNA polymerase sigma factor
WPG_3104	ENOG4108UJV	acyl-CoA thioesterase i
WPG_3105	ENOG4108I0Y	(ABC) transporter
WPG_3107	ENOG4105EZV	Transcriptional regulator
WPG_3113	ENOG4105EE1	crotonyl-CoA reductase
WPG_3126	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
WPG_3131	ENOG4108WQH	regulatoR
WPG_3132	ENOG4105BZU	Histidine kinase
WPG_3149	ENOG4108NEV	two component transcriptional regulator, LytTR family
WPG_3159	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
WPG_3161	ENOG4108K5P	(LipO)protein
WPG_3166	ENOG4105VEQ	Cold shock protein
WPG_3176	ENOG4105VCH	membrane
WPG_3177	ENOG4105CUY	Mechanosensitive ion channel
WPG_3181	ENOG4108IND	Tetr family transcriptional regulator
WPG_3182	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
WPG_3188	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
WPG_3189	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
WPG_3190	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
WPG_3191	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
WPG_3192	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
WPG_3193	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
WPG_3194	ENOG4105CIH	Imidazole acetol-phosphate transaminase
WPG_3195	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
WPG_3196	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
WPG_3199	ENOG4105CHR	reductase
WPG_3200	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
WPG_3202	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
WPG_3203	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
WPG_3204	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
WPG_3205	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
WPG_3206	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
WPG_3208	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
WPG_3212	ENOG4105DCF	alanine dehydrogenase
WPG_3215	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
WPG_3220	ENOG4105CG5	Glycosyl transferase (Group 1
WPG_3223	ENOG4105CPK	Glycosyl transferase (Group 1
WPG_3224	ENOG4107XU6	Glycosyl transferase (Group 1
WPG_3225	ENOG4105CAQ	asparagine synthetase
WPG_3227	ENOG4105D3Q	Sugar transferase
WPG_3230	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
WPG_3235	ENOG4105D49	3-dehydroquinate synthase
WPG_3237	ENOG4108VVK	transcriptional Regulator, AsnC
WPG_3241	ENOG4105EE5	Membrane protein terC
WPG_3242	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
WPG_3244	ENOG4105DF5	DNA topoisomerase IV, subunit A
WPG_3246	ENOG4105DNX	Dna topoisomerase iv (Subunit b)
WPG_3251	ENOG4105C3G	gtp-binding protein
WPG_3256	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
WPG_3258	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
WPG_3259	ENOG4108JQ1	Dehydrogenase
WPG_3270	ENOG4105C9Q	fumarate hydratase class II
WPG_3272	ENOG4105CI2	imidazolone-5-propionate hydrolase
WPG_3281	ENOG4107VIJ	nudix hydrolase
WPG_3290	ENOG4105C5H	ABC transporter
WPG_3294	ENOG4105C2I	pirin domain protein
WPG_3295	ENOG4105EUB	pirin domain protein
WPG_3298	ENOG4107QX3	carboxylase
WPG_3299	ENOG4108ITV	Inner membrane protein yqcE
WPG_3304	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
WPG_3305	ENOG4105CTQ	phosphohexokinase
WPG_3307	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
WPG_3315	ENOG4105CTJ	Metal Dependent Phosphohydrolase
WPG_3316	ENOG4105CHU	acetyl-coa acetyltransferase
WPG_3317	ENOG4107SN7	NLP P60 protein
WPG_3322	ENOG4105C84	Histidine ammonia-lyase
WPG_3323	ENOG4107ZT5	Thiol disulfide interchange protein
WPG_3324	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
WPG_3325	ENOG4105CFH	Aspartokinase
WPG_3326	ENOG4107RDY	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
WPG_3327	ENOG4105D98	threonine synthase
WPG_3335	ENOG4105CP2	von willebrand factor, type a
WPG_3338	ENOG4105DIA	mandelate racemase muconate lactonizing
WPG_3343	ENOG4107ZT5	Thiol disulfide interchange protein
WPG_3352	ENOG4105DQ6	Transposase
WPG_3359	ENOG4107QHE	Choloylglycine hydrolase
WPG_3360	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
WPG_3369	ENOG4108Q35	Adenylate
WPG_3370	ENOG4107W2A	UPF0173 metal-dependent hydrolase
WPG_3371	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
WPG_3374	ENOG4105QNR	S1 RNA binding domain protein
WPG_3376	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
WPG_3377	ENOG4105E4F	Isochorismate synthase
WPG_3378	ENOG4105KA0	thioesterase Superfamily protein
WPG_3385	ENOG4105CHH	sulfate transporter
WPG_3387	ENOG4105EA8	2-Nitropropane dioxygenase
WPG_3388	ENOG4105DR4	Methyltransferase
WPG_3396	ENOG4105DE9	3-keto-5-aminohexanoate cleavage enzyme
WPG_3401	ENOG4105CFG	Acts as a chaperone (By similarity)
WPG_3403	ENOG4105EJQ	L-serine dehydratase
WPG_3405	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
WPG_3407	ENOG4105BZU	Histidine kinase
WPG_3410	ENOG4107R7A	Allophanate hydrolase subunit 2
WPG_3411	ENOG4105P4J	Allophanate hydrolase, subunit 1
WPG_3412	ENOG4105E7W	lamb ycsf family protein
WPG_3413	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
WPG_3416	ENOG4105C0P	Mg chelatase subunit ChlI
WPG_3419	ENOG4105CPN	adenine deaminase
WPG_3420	ENOG4107THF	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
WPG_3424	ENOG4105C1J	atp-dependent rna helicase
WPG_3434	ENOG4105DY9	regulatoR
WPG_3437	ENOG4105RKW	reductase (By
WPG_3438	ENOG4107QN2	dihydrolipoyl dehydrogenase
WPG_3442	ENOG4108XM1	transcriptional regulator AsnC family
WPG_3445	ENOG4105DFD	Na H antiporter
WPG_3447	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
WPG_3449	ENOG4105C5H	ABC transporter
WPG_3451	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
WPG_3453	ENOG4105E1F	short-chain dehydrogenase reductase
WPG_3455	ENOG4105C27	TonB-dependent Receptor Plug
WPG_3462	ENOG4108HRK	Histidine kinase
WPG_3463	ENOG4108NEV	two component transcriptional regulator, LytTR family
WPG_3464	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
WPG_3466	ENOG4105D3G	Pseudouridine synthase
WPG_3476	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
WPG_3478	ENOG4108IG5	Transcriptional regulator
WPG_3480	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
WPG_3483	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
WPG_3486	ENOG4105GYP	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity)
WPG_3487	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
WPG_3488	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
WPG_3489	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
WPG_3492	ENOG4105DFA	alanine racemase domain protein
WPG_3493	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
WPG_3495	ENOG4105EYW	Ion transport protein
WPG_3496	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
WPG_3499	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
WPG_3504	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
WPG_3505	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
WPG_3511	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
WPG_3514	ENOG4105CGH	5'-nucleotidase
WPG_3517	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
WPG_3518	ENOG4108URH	decarboxylase
WPG_3519	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
WPG_3520	ENOG4108MJ3	acetyltransferase
WPG_3522	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
WPG_3526	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein