locus-tag	class	description
WPG_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WPG_0002	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WPG_0007	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WPG_0009	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WPG_0010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WPG_0018	COG0402	S-adenosylhomocysteine deaminase activity
WPG_0022	COG3275	phosphorelay sensor kinase activity
WPG_0027	COG0105	UTP biosynthetic process
WPG_0028	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WPG_0030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WPG_0034	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
WPG_0035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WPG_0037	COG1233	COG1233 Phytoene dehydrogenase and related
WPG_0040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WPG_0043	COG0714	Associated with various cellular activities
WPG_0044	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WPG_0046	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WPG_0052	COG0516	GMP reductase activity
WPG_0052	COG0517	IMP dehydrogenase activity
WPG_0065	COG0167	dihydroorotate dehydrogenase activity
WPG_0066	COG2195	Cleaves the N-terminal amino acid of tripeptides
WPG_0069	COG1862	Preprotein translocase
WPG_0071	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WPG_0073	COG1132	(ABC) transporter
WPG_0076	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WPG_0079	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WPG_0082	COG1252	NADH dehydrogenase
WPG_0088	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WPG_0096	COG0714	Associated with various cellular activities
WPG_0115	COG2133	pyrroloquinoline quinone binding
WPG_0119	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WPG_0121	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WPG_0121	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WPG_0123	COG1192	Involved in chromosome partitioning
WPG_0124	COG1475	DNA binding
WPG_0126	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WPG_0127	COG0681	Belongs to the peptidase S26 family
WPG_0132	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WPG_0135	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WPG_0137	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WPG_0145	COG1131	(ABC) transporter
WPG_0147	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WPG_0149	COG0514	ATP-dependent DNA helicase (RecQ)
WPG_0151	COG0805	protein transport
WPG_0153	COG1137	ATPase activity
WPG_0155	COG1253	flavin adenine dinucleotide binding
WPG_0156	COG1183	phosphatidylcholine synthase activity
WPG_0159	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WPG_0162	COG0438	transferase activity, transferring glycosyl groups
WPG_0168	COG1696	Membrane protein involved in D-alanine export
WPG_0170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WPG_0171	COG2089	acid synthase
WPG_0174	COG1215	transferase activity, transferring glycosyl groups
WPG_0176	COG1215	transferase activity, transferring glycosyl groups
WPG_0178	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WPG_0186	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WPG_0187	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WPG_0190	COG0488	(ABC) transporter
WPG_0192	COG1136	(ABC) transporter
WPG_0196	COG0653	protein targeting
WPG_0199	COG0564	pseudouridine synthase activity
WPG_0209	COG1595	DNA-templated transcription, initiation
WPG_0211	COG1703	isobutyryl-CoA mutase activity
WPG_0212	COG0463	Glycosyl transferase, family 2
WPG_0213	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WPG_0213	COG3952	Lipid A Biosynthesis
WPG_0215	COG0671	phosphoesterase, PA-phosphatase related
WPG_0217	COG0534	Mate efflux family protein
WPG_0220	COG0482	sulfurtransferase activity
WPG_0222	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
WPG_0224	COG0706	membrane insertase activity
WPG_0225	COG0504	CTP synthase activity
WPG_0228	COG0336	Belongs to the RNA methyltransferase TrmD family
WPG_0230	COG0335	large ribosomal subunit rRNA binding
WPG_0235	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
WPG_0237	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WPG_0238	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WPG_0239	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WPG_0240	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WPG_0241	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
WPG_0246	COG0305	Participates in initiation and elongation during chromosome replication
WPG_0247	COG0825	malonyl-CoA metabolic process
WPG_0250	COG0343	queuine tRNA-ribosyltransferase activity
WPG_0251	COG3959	Transketolase, thiamine diphosphate binding domain
WPG_0253	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WPG_0255	COG2195	Cleaves the N-terminal amino acid of tripeptides
WPG_0257	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WPG_0262	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WPG_0263	COG0501	Belongs to the peptidase M48B family
WPG_0266	COG1858	cytochrome C peroxidase
WPG_0267	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WPG_0269	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WPG_0271	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WPG_0275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WPG_0278	COG3956	TIGRFAM MazG family protein
WPG_0280	COG0242	peptide deformylase activity
WPG_0281	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WPG_0282	COG2171	N-acyltransferase activity
WPG_0284	COG0463	Glycosyl transferase, family 2
WPG_0284	COG1216	Glycosyl transferase, family 2
WPG_0285	COG1216	Glycosyl transferase, family 2
WPG_0286	COG0463	Glycosyl transferase, family 2
WPG_0292	COG0617	tRNA 3'-terminal CCA addition
WPG_0294	COG1612	heme a metabolic process
WPG_0297	COG1131	(ABC) transporter
WPG_0307	COG0556	nucleotide-excision repair
WPG_0311	COG0045	succinate-CoA ligase (ADP-forming) activity
WPG_0313	COG0019	diaminopimelate decarboxylase activity
WPG_0318	COG0823	Involved in the tonB-independent uptake of proteins
WPG_0318	COG4946	Tricorn protease homolog
WPG_0318	COG1506	peptidase
WPG_0326	COG2326	polyphosphate kinase activity
WPG_0327	COG0655	NAD(P)H dehydrogenase (quinone) activity
WPG_0330	COG3264	Mechanosensitive ion channel
WPG_0330	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WPG_0331	COG1668	transmembrane transport
WPG_0332	COG4152	abc transporter atp-binding protein
WPG_0333	COG0484	heat shock protein binding
WPG_0334	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WPG_0338	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WPG_0340	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WPG_0340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WPG_0341	COG1090	epimerase
WPG_0344	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
WPG_0352	COG1522	sequence-specific DNA binding
WPG_0355	COG1595	DNA-templated transcription, initiation
WPG_0356	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WPG_0356	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WPG_0356	COG1703	isobutyryl-CoA mutase activity
WPG_0357	COG0788	formyltetrahydrofolate deformylase activity
WPG_0361	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WPG_0362	COG0284	orotidine-5'-phosphate decarboxylase activity
WPG_0363	COG0563	adenylate kinase activity
WPG_0364	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WPG_0371	COG0174	glutamine synthetase
WPG_0377	COG2356	endonuclease I
WPG_0381	COG4206	TonB-dependent receptor
WPG_0386	COG1960	acyl-CoA dehydrogenase activity
WPG_0389	COG2423	ornithine cyclodeaminase activity
WPG_0393	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WPG_0394	COG2091	lysine biosynthetic process via aminoadipic acid
WPG_0395	COG0666	response to abiotic stimulus
WPG_0412	COG0730	response to heat
WPG_0413	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WPG_0416	COG2264	protein methyltransferase activity
WPG_0417	COG0149	triose-phosphate isomerase activity
WPG_0421	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WPG_0426	COG1132	(ABC) transporter
WPG_0427	COG0101	tRNA pseudouridine synthase activity
WPG_0431	COG0268	Binds directly to 16S ribosomal RNA
WPG_0432	COG0442	prolyl-tRNA aminoacylation
WPG_0437	COG0302	gtp cyclohydrolase
WPG_0438	COG0215	cysteine-tRNA ligase activity
WPG_0439	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
WPG_0440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WPG_0443	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WPG_0446	COG0039	L-malate dehydrogenase activity
WPG_0452	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WPG_0456	COG0187	DNA topoisomerase II activity
WPG_0457	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
WPG_0458	COG0367	asparagine synthase
WPG_0460	COG0367	asparagine synthase
WPG_0468	COG0602	queuosine metabolic process
WPG_0469	COG0251	oxidation-reduction process
WPG_0470	COG0433	COG0433 Predicted ATPase
WPG_0472	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WPG_0472	COG0662	Cupin 2, conserved barrel domain protein
WPG_0483	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WPG_0484	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WPG_0487	COG3712	iron ion homeostasis
WPG_0489	COG2318	DinB family
WPG_0491	COG0018	arginyl-trna synthetase
WPG_0492	COG3867	Arabinogalactan endo-beta-1,4-galactanase
WPG_0499	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WPG_0501	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WPG_0501	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WPG_0502	COG0799	negative regulation of ribosome biogenesis
WPG_0503	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WPG_0506	COG0688	phosphatidylethanolamine metabolic process
WPG_0510	COG0148	phosphopyruvate hydratase activity
WPG_0513	COG0203	ribosomal protein L17
WPG_0514	COG0202	RNA polymerase activity
WPG_0515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WPG_0516	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WPG_0517	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WPG_0518	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WPG_0519	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WPG_0521	COG0200	Binds to the 23S rRNA
WPG_0522	COG1841	ribosomal large subunit assembly
WPG_0523	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WPG_0524	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WPG_0525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WPG_0526	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WPG_0527	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WPG_0528	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WPG_0529	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WPG_0530	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WPG_0531	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WPG_0532	COG0255	Belongs to the universal ribosomal protein uL29 family
WPG_0533	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WPG_0534	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WPG_0535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WPG_0536	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WPG_0537	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WPG_0538	COG0089	rRNA binding
WPG_0539	COG0088	Forms part of the polypeptide exit tunnel
WPG_0540	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WPG_0541	COG0051	transcription antitermination factor activity, RNA binding
WPG_0542	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WPG_0543	COG0049	tRNA binding
WPG_0544	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WPG_0546	COG4206	TonB-dependent receptor
WPG_0546	COG1629	transport
WPG_0548	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WPG_0550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WPG_0553	COG1011	Hydrolase
WPG_0555	COG2003	Belongs to the UPF0758 family
WPG_0566	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WPG_0580	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WPG_0581	COG0563	adenylate kinase activity
WPG_0582	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WPG_0583	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WPG_0584	COG0339	signal peptide processing
WPG_0592	COG1090	epimerase
WPG_0596	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WPG_0596	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WPG_0597	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WPG_0599	COG1215	transferase activity, transferring glycosyl groups
WPG_0601	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WPG_0602	COG1127	ABC transporter
WPG_0606	COG2304	oxidoreductase activity
WPG_0610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WPG_0615	COG0508	dehydrogenase complex catalyzes the overall conversion of
WPG_0616	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WPG_0617	COG0295	cytidine deaminase activity
WPG_0620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WPG_0621	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WPG_0622	COG0285	dihydrofolate synthase activity
WPG_0624	COG0848	biopolymer transport protein
WPG_0625	COG0811	peptide transport
WPG_0629	COG1960	acyl-CoA dehydrogenase activity
WPG_0630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WPG_0636	COG1629	transport
WPG_0636	COG4206	TonB-dependent receptor
WPG_0637	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WPG_0643	COG0321	lipoyl(octanoyl) transferase activity
WPG_0646	COG2197	response regulator
WPG_0649	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WPG_0663	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WPG_0664	COG0791	NLP P60 protein
WPG_0664	COG1388	LysM domain
WPG_0665	COG2515	1-aminocyclopropane-1-carboxylate deaminase
WPG_0668	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
WPG_0670	COG0659	secondary active sulfate transmembrane transporter activity
WPG_0671	COG1278	Cold shock
WPG_0672	COG3781	membrane
WPG_0673	COG0022	dehydrogenase e1 component
WPG_0674	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WPG_0675	COG0508	dehydrogenase complex catalyzes the overall conversion of
WPG_0679	COG1012	belongs to the aldehyde dehydrogenase family
WPG_0679	COG2030	dehydratase
WPG_0680	COG0183	Belongs to the thiolase family
WPG_0682	COG1250	3-hydroxyacyl-CoA dehydrogenase
WPG_0684	COG1024	Enoyl-CoA hydratase
WPG_0685	COG2151	metal-sulfur cluster biosynthetic enzyme
WPG_0686	COG3396	Phenylacetate-CoA oxygenase
WPG_0687	COG3460	Phenylacetate-CoA oxygenase
WPG_0688	COG3396	Phenylacetate-CoA oxygenase
WPG_0689	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WPG_0691	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WPG_0698	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WPG_0699	COG2197	response regulator
WPG_0700	COG0358	DNA primase activity
WPG_0706	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WPG_0707	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WPG_0708	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WPG_0713	COG1988	membrane-bound metal-dependent
WPG_0714	COG1490	D-aminoacyl-tRNA deacylase activity
WPG_0715	COG1162	GTPase activity
WPG_0718	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WPG_0722	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
WPG_0723	COG0287	Prephenate dehydrogenase
WPG_0724	COG0436	Aminotransferase
WPG_0726	COG1131	(ABC) transporter
WPG_0729	COG0633	Ferredoxin
WPG_0730	COG0492	ferredoxin-NADP+ reductase activity
WPG_0733	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WPG_0736	COG1959	2 iron, 2 sulfur cluster binding
WPG_0741	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WPG_0753	COG1428	Deoxynucleoside kinase
WPG_0758	COG3420	alginic acid biosynthetic process
WPG_0759	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
WPG_0760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WPG_0765	COG0508	dehydrogenase complex catalyzes the overall conversion of
WPG_0765	COG0022	dehydrogenase e1 component
WPG_0766	COG2086	electron transfer activity
WPG_0767	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
WPG_0769	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WPG_0770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WPG_0772	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
WPG_0774	COG1131	(ABC) transporter
WPG_0777	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
WPG_0778	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WPG_0779	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WPG_0780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WPG_0785	COG1331	Highly conserved protein containing a thioredoxin domain
WPG_0790	COG2211	Major facilitator Superfamily
WPG_0799	COG1629	transport
WPG_0799	COG4206	TonB-dependent receptor
WPG_0809	COG2146	nitrite reductase [NAD(P)H] activity
WPG_0809	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WPG_0810	COG2192	nodulation
WPG_0813	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WPG_0816	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WPG_0820	COG0438	transferase activity, transferring glycosyl groups
WPG_0821	COG2244	polysaccharide biosynthetic process
WPG_0822	COG2089	acid synthase
WPG_0827	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WPG_0828	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
WPG_0830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WPG_0831	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WPG_0832	COG1086	Polysaccharide biosynthesis protein
WPG_0833	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WPG_0834	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WPG_0837	COG1428	Deoxynucleoside kinase
WPG_0840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WPG_0841	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WPG_0846	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WPG_0847	COG0740	serine-type endopeptidase activity
WPG_0848	COG0544	peptidyl-prolyl cis-trans isomerase activity
WPG_0849	COG1950	PFAM Membrane protein of
WPG_0851	COG0596	Alpha beta hydrolase
WPG_0852	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WPG_0854	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WPG_0856	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WPG_0860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WPG_0862	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WPG_0864	COG3275	phosphorelay sensor kinase activity
WPG_0870	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WPG_0872	COG0668	transmembrane transport
WPG_0873	COG1214	PFAM Peptidase M22, glycoprotease
WPG_0874	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WPG_0876	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WPG_0877	COG0577	efflux transmembrane transporter activity
WPG_0877	COG1136	(ABC) transporter
WPG_0878	COG0577	efflux transmembrane transporter activity
WPG_0878	COG1136	(ABC) transporter
WPG_0879	COG1136	(ABC) transporter
WPG_0881	COG2322	membrane
WPG_0882	COG1999	signal sequence binding
WPG_0886	COG1845	cytochrome c oxidase, subunit III
WPG_0887	COG0109	protoheme IX farnesyltransferase activity
WPG_0895	COG0509	glycine decarboxylation via glycine cleavage system
WPG_0897	COG0632	four-way junction helicase activity
WPG_0898	COG0281	malic enzyme
WPG_0898	COG0280	phosphate acetyltransferase
WPG_0900	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
WPG_0901	COG1858	cytochrome C peroxidase
WPG_0902	COG2255	four-way junction helicase activity
WPG_0903	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WPG_0904	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WPG_0908	COG3743	rRNA binding
WPG_0908	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WPG_0909	COG0437	4 iron, 4 sulfur cluster binding
WPG_0913	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WPG_0914	COG2251	uridine kinase activity
WPG_0914	COG0195	Participates in both transcription termination and antitermination
WPG_0915	COG0779	Required for maturation of 30S ribosomal subunits
WPG_0916	COG0589	response to stress
WPG_0919	COG0726	polysaccharide deacetylase
WPG_0920	COG3118	belongs to the thioredoxin family
WPG_0921	COG1408	metallophosphoesterase
WPG_0923	COG3142	Participates in the control of copper homeostasis
WPG_0924	COG3525	Glycosyl hydrolase, family 20, catalytic domain
WPG_0927	COG3537	Alpha-1,2-mannosidase
WPG_0929	COG1446	asparaginase
WPG_0931	COG4585	Histidine kinase
WPG_0932	COG0745	RESPONSE REGULATOR receiver
WPG_0938	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WPG_0938	COG0189	ligase activity
WPG_0954	COG0009	L-threonylcarbamoyladenylate synthase
WPG_0958	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WPG_0965	COG2813	Specifically methylates the guanine in position
WPG_0972	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WPG_0973	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WPG_0974	COG0052	Belongs to the universal ribosomal protein uS2 family
WPG_0975	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WPG_0976	COG0528	UMP kinase activity
WPG_0977	COG0233	cytoplasmic translational termination
WPG_0980	COG0017	Asparaginyl-tRNA synthetase
WPG_0981	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WPG_0987	COG0811	peptide transport
WPG_0988	COG0252	asparaginase activity
WPG_0989	COG0084	hydrolase, TatD family'
WPG_0991	COG2197	response regulator
WPG_0992	COG0508	dehydrogenase complex catalyzes the overall conversion of
WPG_0993	COG0567	Dehydrogenase, E1 component
WPG_0996	COG0142	geranyltranstransferase activity
WPG_0997	COG1309	transcriptional regulator
WPG_1001	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WPG_1002	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WPG_1008	COG0590	tRNA wobble adenosine to inosine editing
WPG_1011	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WPG_1013	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WPG_1014	COG1629	transport
WPG_1014	COG4206	TonB-dependent receptor
WPG_1020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WPG_1022	COG3279	Response regulator of the LytR AlgR family
WPG_1023	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WPG_1024	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WPG_1024	COG1328	CTP reductase activity
WPG_1033	COG2095	MarC family integral membrane protein
WPG_1036	COG0793	Belongs to the peptidase S41A family
WPG_1039	COG1410	methionine synthase
WPG_1039	COG0646	methionine synthase
WPG_1040	COG2329	Antibiotic biosynthesis monooxygenase
WPG_1042	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
WPG_1052	COG0800	Aldolase
WPG_1055	COG1609	Transcriptional regulator
WPG_1056	COG1028	Short-chain dehydrogenase reductase Sdr
WPG_1057	COG1028	Short-chain dehydrogenase reductase Sdr
WPG_1060	COG2271	Major facilitator Superfamily
WPG_1061	COG2186	Transcriptional regulator
WPG_1074	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WPG_1075	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WPG_1076	COG0193	aminoacyl-tRNA hydrolase activity
WPG_1077	COG0196	riboflavin kinase activity
WPG_1079	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WPG_1083	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WPG_1084	COG2239	Acts as a magnesium transporter
WPG_1087	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WPG_1089	COG2197	response regulator
WPG_1099	COG0527	aspartate kinase activity
WPG_1101	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WPG_1103	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WPG_1108	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WPG_1113	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WPG_1117	COG0659	secondary active sulfate transmembrane transporter activity
WPG_1124	COG2304	oxidoreductase activity
WPG_1125	COG2304	oxidoreductase activity
WPG_1128	COG0714	Associated with various cellular activities
WPG_1130	COG4989	oxidoreductase activity
WPG_1131	COG4221	oxidoreductase activity
WPG_1140	COG1012	belongs to the aldehyde dehydrogenase family
WPG_1141	COG1446	asparaginase
WPG_1143	COG4447	cellulose binding
WPG_1149	COG2329	Antibiotic biosynthesis monooxygenase
WPG_1152	COG4953	penicillin-binding protein 1C
WPG_1162	COG0612	Peptidase, M16
WPG_1163	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WPG_1164	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WPG_1166	COG2234	aminopeptidase activity
WPG_1167	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WPG_1168	COG1053	succinate dehydrogenase
WPG_1176	COG0006	proline dipeptidase activity
WPG_1178	COG1114	Component of the transport system for branched-chain amino acids
WPG_1180	COG2267	carboxylic ester hydrolase activity
WPG_1183	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WPG_1186	COG0316	Belongs to the HesB IscA family
WPG_1187	COG0719	Fe-S assembly protein
WPG_1189	COG0396	ATPase activity
WPG_1190	COG0719	Fe-S assembly protein
WPG_1191	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WPG_1193	COG2166	iron-sulfur cluster assembly
WPG_1194	COG2151	metal-sulfur cluster biosynthetic enzyme
WPG_1197	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WPG_1205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WPG_1207	COG0469	pyruvate kinase activity
WPG_1209	COG0571	ribonuclease III activity
WPG_1210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WPG_1211	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WPG_1213	COG0328	RNA-DNA hybrid ribonuclease activity
WPG_1213	COG3341	Caulimovirus viroplasmin
WPG_1216	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WPG_1217	COG1074	ATP-dependent DNA helicase activity
WPG_1225	COG0720	synthase
WPG_1226	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WPG_1227	COG3119	arylsulfatase activity
WPG_1231	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WPG_1231	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
WPG_1233	COG1765	OsmC-like protein
WPG_1235	COG1573	uracil-dna glycosylase
WPG_1236	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WPG_1239	COG1435	thymidine kinase activity
WPG_1240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WPG_1241	COG1970	mechanosensitive ion channel activity
WPG_1242	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WPG_1244	COG1505	serine-type exopeptidase activity
WPG_1248	COG3842	ATPase activity
WPG_1251	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WPG_1252	COG2234	aminopeptidase activity
WPG_1252	COG4935	Belongs to the peptidase S8 family
WPG_1253	COG0439	Biotin carboxylase
WPG_1254	COG0511	ligase activity, forming carbon-carbon bonds
WPG_1255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WPG_1256	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WPG_1258	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WPG_1265	COG3604	Transcriptional regulator
WPG_1273	COG3525	Glycosyl hydrolase, family 20, catalytic domain
WPG_1275	COG0363	glucosamine-6-phosphate deaminase activity
WPG_1277	COG4206	TonB-dependent receptor
WPG_1277	COG1629	transport
WPG_1278	COG3275	phosphorelay sensor kinase activity
WPG_1279	COG3279	Response regulator of the LytR AlgR family
WPG_1283	COG0346	lactoylglutathione lyase activity
WPG_1284	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WPG_1285	COG4591	ABC-type transport system involved in lipoprotein release permease component
WPG_1286	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WPG_1291	COG0823	Involved in the tonB-independent uptake of proteins
WPG_1293	COG0481	GTPase activity
WPG_1295	COG2197	response regulator
WPG_1299	COG3263	regulation of cellular component size
WPG_1300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WPG_1303	COG0594	ribonuclease P activity
WPG_1304	COG0793	Belongs to the peptidase S41A family
WPG_1306	COG2153	protein acetylation
WPG_1307	COG0698	ribose 5-phosphate isomerase
WPG_1311	COG0557	exoribonuclease II activity
WPG_1312	COG0393	Putative heavy-metal-binding
WPG_1319	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WPG_1325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WPG_1326	COG3239	Fatty acid desaturase
WPG_1328	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WPG_1329	COG0445	tRNA wobble uridine modification
WPG_1332	COG0470	DNA polymerase III
WPG_1333	COG0126	phosphoglycerate kinase activity
WPG_1334	COG1388	LysM domain
WPG_1334	COG0741	lytic transglycosylase activity
WPG_1336	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WPG_1347	COG3551	Protein conserved in bacteria
WPG_1357	COG1215	transferase activity, transferring glycosyl groups
WPG_1359	COG0151	Belongs to the GarS family
WPG_1362	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WPG_1365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WPG_1376	COG0356	it plays a direct role in the translocation of protons across the membrane
WPG_1377	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WPG_1378	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WPG_1379	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WPG_1380	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WPG_1381	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WPG_1385	COG0756	dUTP diphosphatase activity
WPG_1386	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WPG_1391	COG1607	acyl-coa hydrolase
WPG_1393	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WPG_1393	COG0758	DNA mediated transformation
WPG_1394	COG0180	Tryptophanyl-tRNA synthetase
WPG_1399	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WPG_1403	COG1774	PSP1 C-terminal conserved region
WPG_1405	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WPG_1406	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
WPG_1418	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WPG_1419	COG1253	flavin adenine dinucleotide binding
WPG_1426	COG0113	porphobilinogen synthase activity
WPG_1427	COG0556	nucleotide-excision repair
WPG_1431	COG0408	coproporphyrinogen oxidase activity
WPG_1436	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WPG_1438	COG0181	hydroxymethylbilane synthase activity
WPG_1439	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WPG_1443	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WPG_1448	COG1024	Enoyl-CoA hydratase
WPG_1449	COG0673	inositol 2-dehydrogenase activity
WPG_1452	COG2207	Transcriptional regulator
WPG_1454	COG1418	mRNA catabolic process
WPG_1458	COG0484	heat shock protein binding
WPG_1461	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WPG_1462	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WPG_1464	COG1121	(ABC) transporter
WPG_1465	COG0803	Belongs to the bacterial solute-binding protein 9 family
WPG_1466	COG4771	TonB-dependent receptor
WPG_1472	COG1999	signal sequence binding
WPG_1477	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WPG_1479	COG3590	peptidase
WPG_1482	COG0516	GMP reductase activity
WPG_1482	COG0517	IMP dehydrogenase activity
WPG_1485	COG0629	single-stranded DNA binding
WPG_1491	COG4977	sequence-specific DNA binding
WPG_1494	COG1528	Iron-storage protein
WPG_1496	COG3541	Predicted nucleotidyltransferase
WPG_1501	COG1690	Belongs to the RtcB family
WPG_1503	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WPG_1518	COG0123	including yeast histone deacetylase and acetoin utilization protein
WPG_1520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WPG_1520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WPG_1523	COG1619	proteins homologs of microcin C7 resistance protein MccF
WPG_1525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WPG_1527	COG0792	nuclease activity
WPG_1528	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WPG_1529	COG0194	GDP metabolic process
WPG_1530	COG1561	YicC-like family, N-terminal region
WPG_1538	COG0626	cystathionine gamma-synthase activity
WPG_1540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WPG_1542	COG1381	Involved in DNA repair and RecF pathway recombination
WPG_1548	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WPG_1551	COG2268	Band 7 protein
WPG_1555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WPG_1556	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WPG_1558	COG0156	8-amino-7-oxononanoate synthase activity
WPG_1563	COG3655	Transcriptional regulator
WPG_1564	COG2135	peptidase activity
WPG_1565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WPG_1568	COG3279	Response regulator of the LytR AlgR family
WPG_1569	COG3275	phosphorelay sensor kinase activity
WPG_1571	COG0673	inositol 2-dehydrogenase activity
WPG_1572	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WPG_1575	COG1629	transport
WPG_1575	COG4206	TonB-dependent receptor
WPG_1576	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WPG_1578	COG0297	glycogen (starch) synthase activity
WPG_1579	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WPG_1580	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
WPG_1585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WPG_1588	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WPG_1590	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WPG_1591	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WPG_1593	COG0189	ligase activity
WPG_1594	COG0322	excinuclease ABC activity
WPG_1595	COG1752	Esterase of the alpha-beta hydrolase superfamily
WPG_1596	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WPG_1598	COG3185	4-Hydroxyphenylpyruvate dioxygenase
WPG_1600	COG3483	tryptophan 2,3-dioxygenase activity
WPG_1602	COG0166	Belongs to the GPI family
WPG_1608	COG1194	a g-specific adenine glycosylase
WPG_1609	COG0776	regulation of translation
WPG_1610	COG1530	ribonuclease E activity
WPG_1611	COG0667	Aldo Keto reductase
WPG_1613	COG0708	Exodeoxyribonuclease III
WPG_1619	COG0423	glycine-tRNA ligase activity
WPG_1621	COG1040	competence protein
WPG_1623	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WPG_1625	COG0436	Aminotransferase
WPG_1633	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WPG_1635	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
WPG_1640	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WPG_1643	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WPG_1644	COG0537	adenosine 5'-monophosphoramidase activity
WPG_1645	COG3852	Histidine kinase
WPG_1646	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WPG_1648	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WPG_1651	COG0519	Catalyzes the synthesis of GMP from XMP
WPG_1654	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WPG_1655	COG1968	undecaprenyl-diphosphatase activity
WPG_1661	COG2177	Part of the ABC transporter FtsEX involved in
WPG_1662	COG0495	leucyl-tRNA aminoacylation
WPG_1664	COG0686	Belongs to the AlaDH PNT family
WPG_1667	COG1522	sequence-specific DNA binding
WPG_1669	COG2363	Small membrane protein
WPG_1670	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
WPG_1673	COG0463	Glycosyl transferase, family 2
WPG_1674	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WPG_1676	COG1090	epimerase
WPG_1677	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WPG_1681	COG0745	RESPONSE REGULATOR receiver
WPG_1682	COG5002	protein histidine kinase activity
WPG_1684	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WPG_1687	COG0489	protein tyrosine kinase activity
WPG_1688	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WPG_1689	COG0492	ferredoxin-NADP+ reductase activity
WPG_1690	COG0633	Ferredoxin
WPG_1694	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WPG_1695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WPG_1696	COG0228	four-way junction DNA binding
WPG_1702	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WPG_1705	COG4585	Histidine kinase
WPG_1714	COG0463	Glycosyl transferase, family 2
WPG_1717	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WPG_1719	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WPG_1723	COG2315	Protein conserved in bacteria
WPG_1725	COG0784	Response regulator, receiver
WPG_1727	COG4251	negative regulation of phosphorylation
WPG_1729	COG5002	protein histidine kinase activity
WPG_1731	COG3279	Response regulator of the LytR AlgR family
WPG_1732	COG0745	RESPONSE REGULATOR receiver
WPG_1738	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WPG_1740	COG0438	transferase activity, transferring glycosyl groups
WPG_1742	COG0110	maltose O-acetyltransferase activity
WPG_1753	COG1482	cell wall glycoprotein biosynthetic process
WPG_1754	COG2824	Alkylphosphonate utilization operon protein PhnA
WPG_1761	COG2234	aminopeptidase activity
WPG_1766	COG1523	belongs to the glycosyl hydrolase 13 family
WPG_1768	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WPG_1769	COG4206	TonB-dependent receptor
WPG_1769	COG1629	transport
WPG_1772	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WPG_1773	COG1554	hydrolase, family 65, central catalytic
WPG_1774	COG0366	Alpha amylase catalytic
WPG_1775	COG2819	hydrolase of the alpha beta superfamily
WPG_1776	COG1501	Belongs to the glycosyl hydrolase 31 family
WPG_1778	COG0366	Alpha amylase catalytic
WPG_1782	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WPG_1785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WPG_1789	COG2081	HI0933 family
WPG_1794	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WPG_1796	COG1187	pseudouridine synthase activity
WPG_1797	COG2205	protein histidine kinase activity
WPG_1797	COG0784	Response regulator, receiver
WPG_1809	COG1215	transferase activity, transferring glycosyl groups
WPG_1814	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WPG_1825	COG0463	Glycosyl transferase, family 2
WPG_1829	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
WPG_1835	COG3608	succinylglutamate desuccinylase aspartoacylase
WPG_1835	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
WPG_1839	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WPG_1841	COG0590	tRNA wobble adenosine to inosine editing
WPG_1842	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WPG_1843	COG3938	Belongs to the proline racemase family
WPG_1845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WPG_1847	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WPG_1850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WPG_1851	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WPG_1852	COG0066	3-isopropylmalate dehydratase activity
WPG_1853	COG0473	3-isopropylmalate dehydrogenase activity
WPG_1854	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WPG_1855	COG0004	ammonium transporteR
WPG_1857	COG0004	ammonium transporteR
WPG_1859	COG0069	glutamate synthase activity
WPG_1859	COG0067	glutamate synthase
WPG_1859	COG0070	glutamate synthase
WPG_1861	COG0165	Argininosuccinate lyase
WPG_1863	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WPG_1865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WPG_1866	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WPG_1867	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WPG_1868	COG0137	argininosuccinate synthase activity
WPG_1870	COG1012	belongs to the aldehyde dehydrogenase family
WPG_1871	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WPG_1872	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WPG_1874	COG0028	Belongs to the TPP enzyme family
WPG_1875	COG0129	dihydroxy-acid dehydratase activity
WPG_1876	COG2814	Major facilitator Superfamily
WPG_1876	COG0477	Major facilitator Superfamily
WPG_1879	COG1609	Transcriptional regulator
WPG_1880	COG4206	TonB-dependent receptor
WPG_1880	COG1629	transport
WPG_1887	COG0572	uridine kinase
WPG_1891	COG0738	Major facilitator superfamily
WPG_1892	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WPG_1893	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WPG_1894	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
WPG_1900	COG2211	Major facilitator Superfamily
WPG_1901	COG0673	inositol 2-dehydrogenase activity
WPG_1905	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WPG_1906	COG0366	Alpha amylase catalytic
WPG_1907	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
WPG_1916	COG1506	peptidase
WPG_1916	COG0823	Involved in the tonB-independent uptake of proteins
WPG_1917	COG3104	oligopeptide transport
WPG_1918	COG4232	protein-disulfide reductase activity
WPG_1919	COG2333	competence protein COMEC
WPG_1919	COG0658	competence protein
WPG_1920	COG0791	NLP P60 protein
WPG_1921	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WPG_1923	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WPG_1924	COG0793	Belongs to the peptidase S41A family
WPG_1925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WPG_1926	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WPG_1927	COG2267	carboxylic ester hydrolase activity
WPG_1928	COG2001	Belongs to the MraZ family
WPG_1929	COG0275	rRNA processing
WPG_1931	COG0768	penicillin binding
WPG_1932	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WPG_1933	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WPG_1934	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WPG_1935	COG0772	Belongs to the SEDS family
WPG_1936	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WPG_1937	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WPG_1940	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WPG_1941	COG1610	YqeY-like protein
WPG_1948	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
WPG_1949	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WPG_1951	COG0529	Catalyzes the synthesis of activated sulfate
WPG_1955	COG1132	(ABC) transporter
WPG_1959	COG1216	Glycosyl transferase, family 2
WPG_1960	COG0110	maltose O-acetyltransferase activity
WPG_1962	COG1216	Glycosyl transferase, family 2
WPG_1967	COG0297	glycogen (starch) synthase activity
WPG_1975	COG1216	Glycosyl transferase, family 2
WPG_1976	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WPG_1978	COG0489	protein tyrosine kinase activity
WPG_1979	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WPG_1980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WPG_1985	COG1185	polyribonucleotide nucleotidyltransferase activity
WPG_1986	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WPG_1989	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WPG_1990	COG0191	fructose-bisphosphate aldolase activity
WPG_1994	COG2226	methyltransferase
WPG_1995	COG0569	domain protein
WPG_1996	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WPG_2001	COG3239	Fatty acid desaturase
WPG_2002	COG0357	Ribosomal RNA small subunit methyltransferase G
WPG_2006	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WPG_2009	COG1012	belongs to the aldehyde dehydrogenase family
WPG_2011	COG2967	ApaG domain
WPG_2012	COG0076	glutamate decarboxylase activity
WPG_2015	COG1805	sodium ion transport
WPG_2016	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WPG_2017	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WPG_2018	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WPG_2021	COG0471	metal ion transport
WPG_2024	COG1477	protein flavinylation
WPG_2028	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WPG_2030	COG0501	Belongs to the peptidase M48B family
WPG_2032	COG3340	Belongs to the peptidase S51 family
WPG_2037	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WPG_2041	COG0662	Cupin 2, conserved barrel domain protein
WPG_2042	COG1028	Short-chain dehydrogenase reductase Sdr
WPG_2050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WPG_2051	COG3844	kynureninase activity
WPG_2058	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WPG_2059	COG1663	tetraacyldisaccharide 4'-kinase activity
WPG_2060	COG0784	Response regulator, receiver
WPG_2060	COG5002	protein histidine kinase activity
WPG_2061	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WPG_2062	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WPG_2068	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WPG_2070	COG1595	DNA-templated transcription, initiation
WPG_2071	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WPG_2072	COG0436	Aminotransferase
WPG_2075	COG0525	valine-tRNA ligase activity
WPG_2077	COG0772	Belongs to the SEDS family
WPG_2078	COG0768	penicillin binding
WPG_2081	COG1077	Cell shape determining protein MreB Mrl
WPG_2084	COG0138	bifunctional purine biosynthesis protein purh
WPG_2095	COG0459	protein refolding
WPG_2096	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WPG_2103	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WPG_2108	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WPG_2114	COG0488	(ABC) transporter
WPG_2129	COG1574	metal-dependent hydrolase with the TIM-barrel fold
WPG_2131	COG1595	DNA-templated transcription, initiation
WPG_2132	COG0596	Alpha beta hydrolase
WPG_2162	COG3279	Response regulator of the LytR AlgR family
WPG_2163	COG3275	phosphorelay sensor kinase activity
WPG_2166	COG1136	(ABC) transporter
WPG_2167	COG1136	(ABC) transporter
WPG_2167	COG0577	efflux transmembrane transporter activity
WPG_2173	COG3609	addiction module antidote protein, CC2985 family
WPG_2204	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WPG_2221	COG3421	Type III restriction
WPG_2222	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WPG_2229	COG4974	Belongs to the 'phage' integrase family
WPG_2231	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WPG_2234	COG1160	GTP binding
WPG_2243	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WPG_2246	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WPG_2247	COG1181	Belongs to the D-alanine--D-alanine ligase family
WPG_2249	COG0564	pseudouridine synthase activity
WPG_2250	COG3022	response to hydroperoxide
WPG_2255	COG0513	Belongs to the DEAD box helicase family
WPG_2257	COG4628	conserved protein (DUF2132)
WPG_2264	COG0159	tryptophan synthase activity
WPG_2265	COG0133	tryptophan synthase activity
WPG_2266	COG0135	phosphoribosylanthranilate isomerase activity
WPG_2267	COG0134	indole-3-glycerol-phosphate synthase activity
WPG_2268	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WPG_2269	COG0512	Glutamine amidotransferase of anthranilate synthase
WPG_2270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WPG_2272	COG0386	Belongs to the glutathione peroxidase family
WPG_2273	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WPG_2279	COG3852	Histidine kinase
WPG_2282	COG1136	(ABC) transporter
WPG_2283	COG0577	efflux transmembrane transporter activity
WPG_2285	COG0577	efflux transmembrane transporter activity
WPG_2288	COG0577	efflux transmembrane transporter activity
WPG_2291	COG1136	(ABC) transporter
WPG_2300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WPG_2301	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WPG_2311	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WPG_2339	COG3177	Filamentation induced by cAMP protein fic
WPG_2341	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WPG_2355	COG2020	methyltransferase activity
WPG_2360	COG3177	Filamentation induced by cAMP protein fic
WPG_2380	COG0300	oxidoreductase activity
WPG_2384	COG2949	membrane
WPG_2391	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WPG_2403	COG2244	polysaccharide biosynthetic process
WPG_2407	COG0438	transferase activity, transferring glycosyl groups
WPG_2409	COG1215	transferase activity, transferring glycosyl groups
WPG_2411	COG2884	Cell division ATP-binding protein ftsE
WPG_2415	COG1574	metal-dependent hydrolase with the TIM-barrel fold
WPG_2420	COG0584	glycerophosphoryl diester phosphodiesterase
WPG_2422	COG3876	Protein conserved in bacteria
WPG_2430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WPG_2431	COG1115	amino acid carrier protein
WPG_2432	COG1555	photosystem II stabilization
WPG_2433	COG1960	acyl-CoA dehydrogenase activity
WPG_2434	COG4974	Belongs to the 'phage' integrase family
WPG_2435	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WPG_2436	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WPG_2439	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WPG_2440	COG0081	regulation of translation
WPG_2441	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WPG_2442	COG0222	ribosome binding
WPG_2443	COG0085	RNA polymerase activity
WPG_2444	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WPG_2454	COG2885	chlorophyll binding
WPG_2455	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WPG_2465	COG1073	alpha beta
WPG_2472	COG1595	DNA-templated transcription, initiation
WPG_2479	COG0513	Belongs to the DEAD box helicase family
WPG_2481	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
WPG_2482	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WPG_2483	COG2258	MOSC domain
WPG_2486	COG3250	beta-galactosidase activity
WPG_2487	COG3250	beta-galactosidase activity
WPG_2488	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WPG_2491	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WPG_2493	COG0326	Molecular chaperone. Has ATPase activity
WPG_2494	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WPG_2501	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WPG_2503	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WPG_2505	COG0508	dehydrogenase complex catalyzes the overall conversion of
WPG_2507	COG0436	Aminotransferase
WPG_2511	COG3813	Protein conserved in bacteria
WPG_2513	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WPG_2518	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WPG_2519	COG0179	Fumarylacetoacetate (FAA) hydrolase
WPG_2521	COG1546	Belongs to the CinA family
WPG_2521	COG1058	Belongs to the CinA family
WPG_2522	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WPG_2523	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WPG_2525	COG0552	protein localization to endoplasmic reticulum
WPG_2528	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WPG_2533	COG0612	Peptidase, M16
WPG_2535	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
WPG_2540	COG0519	Catalyzes the synthesis of GMP from XMP
WPG_2540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WPG_2543	COG3530	Putative quorum-sensing-regulated virulence factor
WPG_2557	COG1960	acyl-CoA dehydrogenase activity
WPG_2558	COG0183	Belongs to the thiolase family
WPG_2559	COG1024	Enoyl-CoA hydratase
WPG_2559	COG1250	3-hydroxyacyl-CoA dehydrogenase
WPG_2560	COG1846	Transcriptional regulator
WPG_2563	COG0047	phosphoribosylformylglycinamidine synthase activity
WPG_2563	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WPG_2564	COG2356	endonuclease I
WPG_2565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WPG_2565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WPG_2566	COG1595	DNA-templated transcription, initiation
WPG_2581	COG1595	DNA-templated transcription, initiation
WPG_2582	COG1132	(ABC) transporter
WPG_2583	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WPG_2584	COG0463	Glycosyl transferase, family 2
WPG_2586	COG0254	rRNA binding
WPG_2590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WPG_2595	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WPG_2596	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WPG_2598	COG1607	acyl-coa hydrolase
WPG_2603	COG1120	ATPase activity
WPG_2607	COG4206	TonB-dependent receptor
WPG_2611	COG4640	response to antibiotic
WPG_2622	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WPG_2631	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WPG_2635	COG0673	inositol 2-dehydrogenase activity
WPG_2637	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WPG_2639	COG1295	ribonuclease BN
WPG_2640	COG3279	Response regulator of the LytR AlgR family
WPG_2641	COG3275	phosphorelay sensor kinase activity
WPG_2653	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WPG_2654	COG3279	Response regulator of the LytR AlgR family
WPG_2655	COG0360	Binds together with S18 to 16S ribosomal RNA
WPG_2656	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WPG_2657	COG0359	binds to the 23S rRNA
WPG_2658	COG0584	glycerophosphoryl diester phosphodiesterase
WPG_2660	COG0577	efflux transmembrane transporter activity
WPG_2661	COG0124	histidyl-tRNA synthetase
WPG_2666	COG0402	S-adenosylhomocysteine deaminase activity
WPG_2667	COG3291	Pkd domain containing protein
WPG_2671	COG1678	Uncharacterized ACR, COG1678
WPG_2673	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WPG_2678	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WPG_2683	COG0415	Belongs to the DNA photolyase family
WPG_2687	COG0386	Belongs to the glutathione peroxidase family
WPG_2690	COG0302	gtp cyclohydrolase
WPG_2693	COG0415	Belongs to the DNA photolyase family
WPG_2694	COG3046	protein related to deoxyribodipyrimidine photolyase
WPG_2696	COG0415	Belongs to the DNA photolyase family
WPG_2698	COG0702	epimerase
WPG_2702	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WPG_2705	COG0640	Transcriptional regulator
WPG_2713	COG0424	maF-like protein
WPG_2719	COG1970	mechanosensitive ion channel activity
WPG_2720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WPG_2720	COG1333	cytochrome c biogenesis protein
WPG_2725	COG0626	cystathionine gamma-synthase activity
WPG_2726	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
WPG_2727	COG2234	aminopeptidase activity
WPG_2728	COG2234	aminopeptidase activity
WPG_2734	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WPG_2735	COG0778	Nitroreductase
WPG_2736	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WPG_2738	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WPG_2738	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WPG_2741	COG1674	ftsk spoiiie
WPG_2754	COG2031	fatty acid transporter
WPG_2756	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WPG_2757	COG2356	endonuclease I
WPG_2761	COG0069	glutamate synthase activity
WPG_2762	COG1473	amidohydrolase
WPG_2769	COG0009	L-threonylcarbamoyladenylate synthase
WPG_2770	COG2814	Major facilitator Superfamily
WPG_2772	COG1132	(ABC) transporter
WPG_2774	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WPG_2775	COG0439	Biotin carboxylase
WPG_2777	COG2339	peptidase activity
WPG_2778	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WPG_2780	COG1363	Peptidase, m42
WPG_2782	COG1272	protein, Hemolysin III
WPG_2789	COG1028	Short-chain dehydrogenase reductase Sdr
WPG_2790	COG0778	Nitroreductase
WPG_2791	COG1733	regulation of RNA biosynthetic process
WPG_2805	COG3591	Belongs to the peptidase S1B family
WPG_2809	COG0523	cobalamin synthesis protein
WPG_2817	COG2226	methyltransferase
WPG_2818	COG0116	Belongs to the methyltransferase superfamily
WPG_2820	COG3279	Response regulator of the LytR AlgR family
WPG_2821	COG2972	Histidine kinase
WPG_2833	COG1611	Belongs to the LOG family
WPG_2834	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WPG_2843	COG4946	Tricorn protease homolog
WPG_2843	COG0793	Belongs to the peptidase S41A family
WPG_2844	COG0405	Gamma-glutamyltransferase
WPG_2846	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WPG_2848	COG1560	Kdo2-lipid A biosynthetic process
WPG_2850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WPG_2851	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WPG_2853	COG0592	DNA-directed DNA polymerase activity
WPG_2859	COG1702	phosphate starvation-inducible protein PhoH
WPG_2860	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WPG_2868	COG1595	DNA-templated transcription, initiation
WPG_2870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WPG_2876	COG1104	cysteine desulfurase activity
WPG_2882	COG1418	mRNA catabolic process
WPG_2883	COG4974	Belongs to the 'phage' integrase family
WPG_2885	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WPG_2888	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WPG_2890	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WPG_2891	COG0297	glycogen (starch) synthase activity
WPG_2893	COG0366	Alpha amylase catalytic
WPG_2895	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WPG_2898	COG2270	Major facilitator Superfamily
WPG_2905	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WPG_2906	COG1388	LysM domain
WPG_2906	COG1705	Flagellar rod assembly protein muramidase FlgJ
WPG_2908	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WPG_2909	COG1652	LysM domain
WPG_2909	COG2823	Periplasmic or secreted lipoprotein
WPG_2913	COG0540	Belongs to the ATCase OTCase family
WPG_2915	COG1234	tRNA 3'-trailer cleavage
WPG_2917	COG0259	pyridoxamine-phosphate oxidase activity
WPG_2925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WPG_2931	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WPG_2933	COG0742	ribosomal rna small subunit methyltransferase
WPG_2936	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WPG_2938	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WPG_2941	COG1454	alcohol dehydrogenase
WPG_2949	COG1115	amino acid carrier protein
WPG_2951	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WPG_2954	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WPG_2956	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WPG_2962	COG1393	Belongs to the ArsC family
WPG_2964	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WPG_2967	COG1216	Glycosyl transferase, family 2
WPG_2968	COG1216	Glycosyl transferase, family 2
WPG_2970	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WPG_2974	COG0156	8-amino-7-oxononanoate synthase activity
WPG_2986	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WPG_2990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WPG_2991	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WPG_2997	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WPG_2999	COG1215	transferase activity, transferring glycosyl groups
WPG_3005	COG0251	oxidation-reduction process
WPG_3008	COG0860	N-Acetylmuramoyl-L-alanine amidase
WPG_3010	COG0247	lactate metabolic process
WPG_3010	COG2181	nitrate reductase activity
WPG_3012	COG2181	nitrate reductase activity
WPG_3012	COG0247	lactate metabolic process
WPG_3014	COG3830	Belongs to the UPF0237 family
WPG_3014	COG0560	Phosphoserine phosphatase
WPG_3015	COG1472	Belongs to the glycosyl hydrolase 3 family
WPG_3016	COG0438	transferase activity, transferring glycosyl groups
WPG_3020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WPG_3022	COG0346	lactoylglutathione lyase activity
WPG_3029	COG1595	DNA-templated transcription, initiation
WPG_3035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WPG_3040	COG4974	Belongs to the 'phage' integrase family
WPG_3041	COG0217	transcriptional regulatory protein
WPG_3042	COG2154	pterin-4-alpha-carbinolamine dehydratase
WPG_3044	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WPG_3046	COG0277	FAD linked oxidase domain protein
WPG_3046	COG0247	lactate metabolic process
WPG_3048	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WPG_3050	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
WPG_3051	COG1301	dicarboxylic acid transport
WPG_3052	COG0189	ligase activity
WPG_3057	COG3011	Protein conserved in bacteria
WPG_3058	COG1193	negative regulation of DNA recombination
WPG_3059	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WPG_3065	COG0022	dehydrogenase e1 component
WPG_3074	COG1187	pseudouridine synthase activity
WPG_3096	COG1595	DNA-templated transcription, initiation
WPG_3105	COG4181	ATPase activity
WPG_3107	COG1917	Cupin 2, conserved barrel domain protein
WPG_3107	COG2169	Transcriptional regulator
WPG_3126	COG0405	Gamma-glutamyltransferase
WPG_3131	COG2197	response regulator
WPG_3132	COG4585	Histidine kinase
WPG_3149	COG3279	Response regulator of the LytR AlgR family
WPG_3161	COG4942	peptidase
WPG_3166	COG1278	Cold shock
WPG_3176	COG2814	Major facilitator Superfamily
WPG_3177	COG0668	transmembrane transport
WPG_3181	COG1309	transcriptional regulator
WPG_3188	COG0101	tRNA pseudouridine synthase activity
WPG_3189	COG0140	phosphoribosyl-ATP diphosphatase activity
WPG_3189	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WPG_3190	COG0107	imidazoleglycerol-phosphate synthase activity
WPG_3191	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WPG_3192	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WPG_3193	COG0131	Imidazoleglycerol-phosphate dehydratase
WPG_3193	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WPG_3194	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WPG_3195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WPG_3196	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WPG_3199	COG1028	Short-chain dehydrogenase reductase Sdr
WPG_3200	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WPG_3202	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WPG_3203	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WPG_3204	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WPG_3205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WPG_3205	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WPG_3206	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WPG_3208	COG2204	response regulator
WPG_3215	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
WPG_3222	COG1045	serine acetyltransferase
WPG_3223	COG0438	transferase activity, transferring glycosyl groups
WPG_3225	COG0367	asparagine synthase
WPG_3227	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WPG_3230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WPG_3235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WPG_3237	COG1522	sequence-specific DNA binding
WPG_3241	COG0861	Integral membrane protein TerC family
WPG_3251	COG0012	GTP binding
WPG_3256	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WPG_3258	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WPG_3259	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WPG_3272	COG1228	amidohydrolase
WPG_3281	COG0494	nUDIX hydrolase
WPG_3290	COG0488	(ABC) transporter
WPG_3294	COG1741	Belongs to the pirin family
WPG_3298	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WPG_3299	COG2223	nitrite transmembrane transporter activity
WPG_3304	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WPG_3305	COG0205	6-phosphofructokinase activity
WPG_3307	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WPG_3312	COG0628	permease
WPG_3315	COG1480	7TM receptor with intracellular HD hydrolase
WPG_3316	COG0183	Belongs to the thiolase family
WPG_3317	COG0791	NLP P60 protein
WPG_3320	COG0542	response to heat
WPG_3322	COG2986	histidine ammonia-lyase
WPG_3323	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WPG_3324	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WPG_3325	COG0527	aspartate kinase activity
WPG_3325	COG0460	homoserine dehydrogenase
WPG_3326	COG0083	homoserine kinase activity
WPG_3327	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WPG_3335	COG2304	oxidoreductase activity
WPG_3343	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WPG_3352	COG2801	Transposase and inactivated derivatives
WPG_3359	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
WPG_3360	COG0402	S-adenosylhomocysteine deaminase activity
WPG_3369	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
WPG_3370	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WPG_3371	COG1575	Belongs to the MenA family. Type 1 subfamily
WPG_3374	COG2996	Protein conserved in bacteria
WPG_3376	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WPG_3385	COG0659	secondary active sulfate transmembrane transporter activity
WPG_3387	COG2070	2-Nitropropane dioxygenase
WPG_3388	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WPG_3396	COG3246	L-lysine catabolic process to acetate
WPG_3401	COG0443	Heat shock 70 kDa protein
WPG_3403	COG1760	l-serine dehydratase
WPG_3405	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WPG_3406	COG0564	pseudouridine synthase activity
WPG_3407	COG4585	Histidine kinase
WPG_3410	COG1984	allophanate hydrolase subunit 2
WPG_3411	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
WPG_3413	COG1914	H( )-stimulated, divalent metal cation uptake system
WPG_3416	COG0606	chelatase, subunit chli
WPG_3419	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
WPG_3420	COG0037	tRNA processing
WPG_3424	COG0513	Belongs to the DEAD box helicase family
WPG_3425	COG0668	transmembrane transport
WPG_3427	COG1595	DNA-templated transcription, initiation
WPG_3434	COG3279	Response regulator of the LytR AlgR family
WPG_3437	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WPG_3438	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WPG_3442	COG1522	sequence-specific DNA binding
WPG_3447	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WPG_3449	COG0488	(ABC) transporter
WPG_3451	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WPG_3453	COG0300	oxidoreductase activity
WPG_3455	COG1629	transport
WPG_3455	COG4206	TonB-dependent receptor
WPG_3462	COG3275	phosphorelay sensor kinase activity
WPG_3463	COG3279	Response regulator of the LytR AlgR family
WPG_3464	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WPG_3466	COG0564	pseudouridine synthase activity
WPG_3476	COG0542	response to heat
WPG_3480	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
WPG_3483	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WPG_3486	COG2936	dipeptidyl-peptidase activity
WPG_3487	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WPG_3488	COG0673	inositol 2-dehydrogenase activity
WPG_3489	COG1250	3-hydroxyacyl-CoA dehydrogenase
WPG_3495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WPG_3496	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WPG_3499	COG0237	dephospho-CoA kinase activity
WPG_3501	COG0463	Glycosyl transferase, family 2
WPG_3501	COG1216	Glycosyl transferase, family 2
WPG_3504	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WPG_3505	COG0497	DNA recombination
WPG_3511	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WPG_3514	COG0737	Belongs to the 5'-nucleotidase family
WPG_3517	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WPG_3519	COG2890	protein-(glutamine-N5) methyltransferase activity
WPG_3520	COG0456	acetyltransferase
WPG_3522	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WPG_3522	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WPG_3523	COG1011	Hydrolase
WPG_3526	COG1739	Uncharacterized protein family UPF0029
WPG_3527	COG0824	Thioesterase