locus-tag	class	description
L0Z56_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L0Z56_00025	COG3736	Type IV secretory pathway, component VirB8
L0Z56_00040	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
L0Z56_00045	COG3505	Type IV secretory pathway VirD4
L0Z56_00055	COG2890	protein-(glutamine-N5) methyltransferase activity
L0Z56_00065	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L0Z56_00080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L0Z56_00095	COG0250	Participates in transcription elongation, termination and antitermination
L0Z56_00100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L0Z56_00105	COG0081	regulation of translation
L0Z56_00110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L0Z56_00115	COG0222	ribosome binding
L0Z56_00120	COG0085	RNA polymerase activity
L0Z56_00120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L0Z56_00125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L0Z56_00145	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L0Z56_00175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L0Z56_00180	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L0Z56_00185	COG0823	Involved in the tonB-independent uptake of proteins
L0Z56_00195	COG0484	heat shock protein binding
L0Z56_00255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L0Z56_00265	COG0776	regulation of translation
L0Z56_00280	COG0495	leucyl-tRNA aminoacylation
L0Z56_00290	COG2801	Transposase and inactivated derivatives
L0Z56_00295	COG2801	Transposase and inactivated derivatives
L0Z56_00310	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L0Z56_00325	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L0Z56_00335	COG3827	peptidoglycan binding
L0Z56_00340	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
L0Z56_00375	COG2801	Transposase and inactivated derivatives
L0Z56_00380	COG2801	Transposase and inactivated derivatives
L0Z56_00405	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L0Z56_00410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L0Z56_00440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L0Z56_00450	COG0149	triose-phosphate isomerase activity
L0Z56_00455	COG0758	DNA mediated transformation
L0Z56_00460	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L0Z56_00475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L0Z56_00480	COG1686	Belongs to the peptidase S11 family
L0Z56_00505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L0Z56_00520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L0Z56_00535	COG0187	DNA topoisomerase II activity
L0Z56_00550	COG2801	Transposase and inactivated derivatives
L0Z56_00565	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L0Z56_00580	COG1674	ftsk spoiiie
L0Z56_00635	COG0307	riboflavin synthase, alpha
L0Z56_00645	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L0Z56_00650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L0Z56_00655	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L0Z56_00660	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L0Z56_00670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L0Z56_00680	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L0Z56_00690	COG1845	cytochrome c oxidase, subunit III
L0Z56_00695	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L0Z56_00700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L0Z56_00710	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L0Z56_00725	COG0215	cysteine-tRNA ligase activity
L0Z56_00730	COG3932	Exopolysaccharide synthesis, ExoD
L0Z56_00740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L0Z56_00745	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L0Z56_00755	COG0322	excinuclease ABC activity
L0Z56_00765	COG0752	glycyl-tRNA synthetase alpha subunit
L0Z56_00775	COG0113	porphobilinogen synthase activity
L0Z56_00780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L0Z56_00800	COG1573	uracil-dna glycosylase
L0Z56_00805	COG0242	peptide deformylase activity
L0Z56_00810	COG0849	cell division
L0Z56_00815	COG0024	Methionine aminopeptidase
L0Z56_00820	COG0477	Major facilitator Superfamily
L0Z56_00825	COG0275	rRNA processing
L0Z56_00845	COG0193	aminoacyl-tRNA hydrolase activity
L0Z56_00860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L0Z56_00895	COG2801	Transposase and inactivated derivatives
L0Z56_00900	COG2801	Transposase and inactivated derivatives
L0Z56_00915	COG0237	dephospho-CoA kinase activity
L0Z56_00920	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
L0Z56_00925	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L0Z56_00940	COG1253	flavin adenine dinucleotide binding
L0Z56_00950	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L0Z56_00950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L0Z56_00985	COG0573	inorganic phosphate transmembrane transporter activity
L0Z56_00990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L0Z56_00995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L0Z56_01020	COG0235	Class ii aldolase
L0Z56_01065	COG4804	nuclease activity
L0Z56_01075	COG1381	Involved in DNA repair and RecF pathway recombination
L0Z56_01095	COG2902	Dehydrogenase
L0Z56_01100	COG0542	response to heat
L0Z56_01115	COG1217	gtp-binding protein TYPA
L0Z56_01120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L0Z56_01125	COG1823	symporter activity
L0Z56_01145	COG1138	Cytochrome C-type biogenesis protein
L0Z56_01165	COG3577	Aspartyl protease
L0Z56_01210	COG0756	dUTP diphosphatase activity
L0Z56_01215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L0Z56_01220	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L0Z56_01225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L0Z56_01230	COG2814	Major facilitator Superfamily
L0Z56_01255	COG1322	Protein conserved in bacteria
L0Z56_01265	COG3328	transposase activity
L0Z56_01285	COG2003	Belongs to the UPF0758 family
L0Z56_01315	COG2189	Belongs to the N(4) N(6)-methyltransferase family
L0Z56_01475	COG2963	transposase activity
L0Z56_01485	COG2801	Transposase and inactivated derivatives
L0Z56_01490	COG2801	Transposase and inactivated derivatives
L0Z56_01495	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L0Z56_01500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L0Z56_01505	COG0109	protoheme IX farnesyltransferase activity
L0Z56_01510	COG0328	RNA-DNA hybrid ribonuclease activity
L0Z56_01520	COG0459	protein refolding
L0Z56_01525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L0Z56_01530	COG0354	folic acid binding
L0Z56_01535	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L0Z56_01550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L0Z56_01560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L0Z56_01565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L0Z56_01570	COG0740	serine-type endopeptidase activity
L0Z56_01575	COG0544	peptidyl-prolyl cis-trans isomerase activity
L0Z56_01605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L0Z56_01640	COG1115	amino acid carrier protein
L0Z56_01655	COG0424	maF-like protein
L0Z56_01675	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L0Z56_01695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L0Z56_01725	COG2801	Transposase and inactivated derivatives
L0Z56_01730	COG2801	Transposase and inactivated derivatives
L0Z56_01745	COG0358	DNA primase activity
L0Z56_01755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L0Z56_01765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L0Z56_01775	COG0305	Participates in initiation and elongation during chromosome replication
L0Z56_01785	COG1714	RDD family
L0Z56_01790	COG2003	Belongs to the UPF0758 family
L0Z56_01800	COG1074	ATP-dependent DNA helicase activity
L0Z56_01805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L0Z56_01815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L0Z56_01840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L0Z56_01860	COG2801	Transposase and inactivated derivatives
L0Z56_01865	COG2801	Transposase and inactivated derivatives
L0Z56_01875	COG2239	Acts as a magnesium transporter
L0Z56_01880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L0Z56_01885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L0Z56_01925	COG2814	Major facilitator Superfamily
L0Z56_01940	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L0Z56_01965	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L0Z56_01970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L0Z56_01975	COG2226	methyltransferase
L0Z56_01995	COG3344	reverse transcriptase
L0Z56_02010	COG1132	(ABC) transporter
L0Z56_02020	COG0018	arginyl-trna synthetase
L0Z56_02050	COG4133	protoheme IX ABC transporter activity
L0Z56_02060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L0Z56_02065	COG0477	Major facilitator Superfamily
L0Z56_02070	COG0564	pseudouridine synthase activity
L0Z56_02075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L0Z56_02080	COG1981	membrane
L0Z56_02090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L0Z56_02105	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L0Z56_02115	COG0072	phenylalanine-tRNA ligase activity
L0Z56_02115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L0Z56_02125	COG0356	it plays a direct role in the translocation of protons across the membrane
L0Z56_02130	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L0Z56_02150	COG1612	heme a metabolic process
L0Z56_02155	COG4770	biotin carboxylase activity
L0Z56_02165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L0Z56_02170	COG1053	succinate dehydrogenase
L0Z56_02180	COG0194	GDP metabolic process
L0Z56_02200	COG0012	GTP binding
L0Z56_02210	COG0617	tRNA 3'-terminal CCA addition
L0Z56_02235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L0Z56_02240	COG0805	protein transport
L0Z56_02245	COG1438	arginine binding
L0Z56_02250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L0Z56_02255	COG0765	amino acid transport
L0Z56_02260	COG1126	abc transporter atp-binding protein
L0Z56_02285	COG0284	orotidine-5'-phosphate decarboxylase activity
L0Z56_02300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L0Z56_02305	COG0525	valine-tRNA ligase activity
L0Z56_02325	COG0504	CTP synthase activity
L0Z56_02330	COG0590	tRNA wobble adenosine to inosine editing
L0Z56_02335	COG0477	Major facilitator Superfamily
L0Z56_02345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L0Z56_02350	COG0022	dehydrogenase e1 component
L0Z56_02350	COG0508	dehydrogenase complex catalyzes the overall conversion of
L0Z56_02360	COG0481	GTPase activity
L0Z56_02385	COG0739	heme binding
L0Z56_02390	COG0217	transcriptional regulatory protein
L0Z56_02395	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L0Z56_02405	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L0Z56_02410	COG0281	malic enzyme
L0Z56_02410	COG0280	phosphate acetyltransferase
L0Z56_02430	COG0114	fumarate hydratase activity
L0Z56_02440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L0Z56_02445	COG0148	phosphopyruvate hydratase activity
L0Z56_02450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L0Z56_02480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L0Z56_02485	COG0154	amidase activity
L0Z56_02510	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L0Z56_02565	COG2963	transposase activity
L0Z56_02570	COG2801	Transposase and inactivated derivatives
L0Z56_02575	COG2801	Transposase and inactivated derivatives
L0Z56_02595	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L0Z56_02605	COG0575	Belongs to the CDS family
L0Z56_02610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L0Z56_02620	COG0233	cytoplasmic translational termination
L0Z56_02625	COG0528	UMP kinase activity
L0Z56_02630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L0Z56_02635	COG0052	Belongs to the universal ribosomal protein uS2 family
L0Z56_02645	COG1862	Preprotein translocase
L0Z56_02665	COG3344	reverse transcriptase
L0Z56_02685	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L0Z56_02695	COG0508	dehydrogenase complex catalyzes the overall conversion of
L0Z56_02720	COG0653	protein targeting
L0Z56_02745	COG2801	Transposase and inactivated derivatives
L0Z56_02755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L0Z56_02760	COG0163	prenyltransferase activity
L0Z56_02765	COG3750	Belongs to the UPF0335 family
L0Z56_02770	COG4536	flavin adenine dinucleotide binding
L0Z56_02775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L0Z56_02780	COG0649	NAD binding
L0Z56_02805	COG3621	Patatin-like phospholipase
L0Z56_02945	COG2189	Belongs to the N(4) N(6)-methyltransferase family
L0Z56_02955	COG0666	response to abiotic stimulus
L0Z56_03020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L0Z56_03025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L0Z56_03030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L0Z56_03050	COG1132	(ABC) transporter
L0Z56_03075	COG0697	spore germination
L0Z56_03095	COG2003	Belongs to the UPF0758 family
L0Z56_03100	COG1396	sequence-specific DNA binding
L0Z56_03205	COG2801	Transposase and inactivated derivatives
L0Z56_03210	COG2963	transposase activity
L0Z56_03215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L0Z56_03240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L0Z56_03245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L0Z56_03250	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L0Z56_03255	COG0792	nuclease activity
L0Z56_03265	COG0202	RNA polymerase activity
L0Z56_03270	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L0Z56_03275	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L0Z56_03280	COG0563	adenylate kinase activity
L0Z56_03285	COG0201	protein transport
L0Z56_03295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L0Z56_03305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L0Z56_03315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L0Z56_03340	COG0255	Belongs to the universal ribosomal protein uL29 family
L0Z56_03350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L0Z56_03365	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L0Z56_03375	COG0088	Forms part of the polypeptide exit tunnel
L0Z56_03380	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L0Z56_03385	COG0051	transcription antitermination factor activity, RNA binding
L0Z56_03390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L0Z56_03405	COG0505	Belongs to the CarA family
L0Z56_03420	COG1494	fructose-1,6-bisphosphatase
L0Z56_03435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L0Z56_03435	COG0574	Belongs to the PEP-utilizing enzyme family
L0Z56_03450	COG3344	reverse transcriptase
L0Z56_03460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L0Z56_03480	COG3547	Transposase (IS116 IS110 IS902 family)
L0Z56_03485	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L0Z56_03500	COG1104	cysteine desulfurase activity
L0Z56_03505	COG2945	thiolester hydrolase activity
L0Z56_03520	COG0316	Belongs to the HesB IscA family
L0Z56_03525	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L0Z56_03530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L0Z56_03530	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L0Z56_03540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L0Z56_03550	COG2171	N-acyltransferase activity
L0Z56_03575	COG0768	penicillin binding
L0Z56_03585	COG0606	chelatase, subunit chli
L0Z56_03615	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L0Z56_03630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L0Z56_03635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L0Z56_03640	COG0745	RESPONSE REGULATOR receiver
L0Z56_03655	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
L0Z56_03660	COG0343	queuine tRNA-ribosyltransferase activity
L0Z56_03670	COG0612	Peptidase, M16
L0Z56_03675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L0Z56_03680	COG1271	oxidase subunit
L0Z56_03685	COG1294	oxidase, subunit
L0Z56_03690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L0Z56_03735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L0Z56_03740	COG4974	Belongs to the 'phage' integrase family
L0Z56_03760	COG0450	alkyl hydroperoxide reductase
L0Z56_03775	COG0196	riboflavin kinase activity
L0Z56_03780	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L0Z56_03785	COG0612	Peptidase, M16
L0Z56_03795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L0Z56_03820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L0Z56_03850	COG0629	single-stranded DNA binding
L0Z56_03855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L0Z56_03860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L0Z56_03865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L0Z56_03875	COG0360	Binds together with S18 to 16S ribosomal RNA
L0Z56_03885	COG0359	binds to the 23S rRNA
L0Z56_03900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L0Z56_03915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L0Z56_03920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L0Z56_03930	COG0473	3-isopropylmalate dehydrogenase activity
L0Z56_03945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L0Z56_03965	COG0142	geranyltranstransferase activity
L0Z56_03970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L0Z56_03985	COG3474	cytochrome
L0Z56_04015	COG0442	prolyl-tRNA aminoacylation
L0Z56_04020	COG0736	holo-[acyl-carrier-protein] synthase activity
L0Z56_04050	COG0009	L-threonylcarbamoyladenylate synthase
L0Z56_04060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L0Z56_04070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L0Z56_04115	COG0330	HflC and HflK could
L0Z56_04145	COG0556	nucleotide-excision repair
L0Z56_04165	COG3088	subunit of a heme lyase
L0Z56_04165	COG4235	cytochrome complex assembly
L0Z56_04185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L0Z56_04200	COG0742	ribosomal rna small subunit methyltransferase
L0Z56_04215	COG1340	protein secretion by the type IV secretion system
L0Z56_04215	COG3704	protein secretion by the type IV secretion system
L0Z56_04220	COG3704	protein secretion by the type IV secretion system
L0Z56_04225	COG3704	protein secretion by the type IV secretion system
L0Z56_04230	COG3451	type IV secretory pathway VirB4
L0Z56_04240	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
L0Z56_04255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L0Z56_04270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L0Z56_04275	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L0Z56_04290	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L0Z56_04295	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L0Z56_04300	COG0254	rRNA binding
L0Z56_04305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L0Z56_04320	COG2801	Transposase and inactivated derivatives
L0Z56_04370	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
L0Z56_04385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L0Z56_04385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L0Z56_04400	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L0Z56_04405	COG0552	protein localization to endoplasmic reticulum
L0Z56_04410	COG0822	iron-sulfur transferase activity
L0Z56_04415	COG0316	Belongs to the HesB IscA family
L0Z56_04420	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
L0Z56_04430	COG0681	Belongs to the peptidase S26 family
L0Z56_04440	COG1840	ABC-type Fe3 transport system, periplasmic component
L0Z56_04480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L0Z56_04485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L0Z56_04490	COG1185	polyribonucleotide nucleotidyltransferase activity
L0Z56_04520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L0Z56_04575	COG0626	cystathionine gamma-synthase activity
L0Z56_04585	COG0443	Heat shock 70 kDa protein
L0Z56_04590	COG1530	ribonuclease E activity
L0Z56_04595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L0Z56_04630	COG1121	(ABC) transporter
L0Z56_04635	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L0Z56_04690	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
L0Z56_04695	COG0670	Belongs to the BI1 family
L0Z56_04700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L0Z56_04710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L0Z56_04730	COG0531	amino acid
L0Z56_04750	COG0527	aspartate kinase activity
L0Z56_04775	COG0839	Belongs to the complex I subunit 6 family
L0Z56_04780	COG0713	ATP synthesis coupled electron transport
L0Z56_04785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L0Z56_04790	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L0Z56_04795	COG1007	ATP synthesis coupled electron transport
L0Z56_04800	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L0Z56_04800	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L0Z56_04800	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L0Z56_04800	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L0Z56_04810	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
L0Z56_04840	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L0Z56_04845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L0Z56_04850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L0Z56_04860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L0Z56_04865	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L0Z56_04875	COG0492	ferredoxin-NADP+ reductase activity
L0Z56_04885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L0Z56_04890	COG0416	fatty acid biosynthetic process
L0Z56_04895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L0Z56_04900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L0Z56_04905	COG1127	ABC transporter
L0Z56_04915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L0Z56_04930	COG3344	reverse transcriptase
L0Z56_04940	COG1104	cysteine desulfurase activity
L0Z56_04950	COG0312	modulator of DNA gyrase
L0Z56_04980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L0Z56_04980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L0Z56_04985	COG2801	Transposase and inactivated derivatives
L0Z56_04990	COG2801	Transposase and inactivated derivatives
L0Z56_05025	COG0445	tRNA wobble uridine modification
L0Z56_05045	COG4695	Portal protein
L0Z56_05060	COG0321	lipoyl(octanoyl) transferase activity
L0Z56_05075	COG0047	phosphoribosylformylglycinamidine synthase activity
L0Z56_05095	COG0336	Belongs to the RNA methyltransferase TrmD family
L0Z56_05100	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L0Z56_05105	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L0Z56_05120	COG1253	flavin adenine dinucleotide binding
L0Z56_05125	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L0Z56_05130	COG0436	Aminotransferase
L0Z56_05160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L0Z56_05190	COG1230	cation diffusion facilitator family transporter
L0Z56_05200	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L0Z56_05205	COG1115	amino acid carrier protein
L0Z56_05210	COG1115	amino acid carrier protein
L0Z56_05215	COG1183	phosphatidylcholine synthase activity
L0Z56_05225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L0Z56_05230	COG0484	heat shock protein binding
L0Z56_05235	COG0285	dihydrofolate synthase activity
L0Z56_05250	COG2867	negative regulation of translational initiation
L0Z56_05285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L0Z56_05290	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L0Z56_05300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L0Z56_05315	COG0101	tRNA pseudouridine synthase activity
L0Z56_05325	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L0Z56_05325	COG2857	Cytochrome c1
L0Z56_05330	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L0Z56_05345	COG0484	heat shock protein binding
L0Z56_05355	COG0124	histidyl-tRNA synthetase
L0Z56_05360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L0Z56_05365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L0Z56_05375	COG0493	'glutamate synthase
L0Z56_05375	COG0543	2 iron, 2 sulfur cluster binding
L0Z56_05380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L0Z56_05395	COG0750	zinc metalloprotease
L0Z56_05410	COG0776	regulation of translation
L0Z56_05415	COG0539	negative regulation of cytoplasmic translation
L0Z56_05420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L0Z56_05445	COG1160	GTP binding
L0Z56_05455	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
L0Z56_05465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L0Z56_05470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L0Z56_05490	COG0651	ATP synthesis coupled electron transport
L0Z56_05495	COG0772	Belongs to the SEDS family
L0Z56_05500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L0Z56_05505	COG2094	Belongs to the DNA glycosylase MPG family
L0Z56_05515	COG2255	four-way junction helicase activity
L0Z56_05520	COG0632	four-way junction helicase activity
L0Z56_05565	COG0494	nUDIX hydrolase
L0Z56_05570	COG0084	hydrolase, TatD family'
L0Z56_05580	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L0Z56_05590	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L0Z56_05615	COG1090	epimerase
L0Z56_05630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L0Z56_05635	COG1054	Belongs to the UPF0176 family
L0Z56_05640	COG1178	ABC-type Fe3 transport system permease component
L0Z56_05650	COG3344	reverse transcriptase
L0Z56_05670	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L0Z56_05675	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L0Z56_05675	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L0Z56_05680	COG0628	permease
L0Z56_05690	COG4974	Belongs to the 'phage' integrase family
L0Z56_05705	COG0268	Binds directly to 16S ribosomal RNA
L0Z56_05710	COG0372	Belongs to the citrate synthase family
L0Z56_05730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L0Z56_05740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L0Z56_05745	COG0259	pyridoxamine-phosphate oxidase activity
L0Z56_05755	COG0658	competence protein
L0Z56_05755	COG2333	competence protein COMEC
L0Z56_05765	COG0564	pseudouridine synthase activity
L0Z56_05790	COG0126	phosphoglycerate kinase activity
L0Z56_05800	COG2070	2-Nitropropane dioxygenase
L0Z56_05815	COG3451	type IV secretory pathway VirB4
L0Z56_05835	COG0508	dehydrogenase complex catalyzes the overall conversion of
L0Z56_05850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L0Z56_05860	COG0105	UTP biosynthetic process
L0Z56_05875	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L0Z56_05895	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
L0Z56_05905	COG0142	geranyltranstransferase activity
L0Z56_05910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L0Z56_05915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L0Z56_05930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L0Z56_05935	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
L0Z56_05950	COG0723	plastoquinol--plastocyanin reductase activity
L0Z56_05985	COG1268	BioY protein
L0Z56_05990	COG0778	Nitroreductase
L0Z56_06000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L0Z56_06005	COG0045	succinate-CoA ligase (ADP-forming) activity
L0Z56_06020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L0Z56_06050	COG1475	DNA binding
L0Z56_06070	COG2009	succinate dehydrogenase
L0Z56_06075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L0Z56_06105	COG4591	ABC-type transport system involved in lipoprotein release permease component
L0Z56_06125	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L0Z56_06130	COG0312	modulator of DNA gyrase
L0Z56_06135	COG1278	Cold shock
L0Z56_06140	COG0513	Belongs to the DEAD box helicase family
L0Z56_06150	COG1830	Aldolase
L0Z56_06160	COG0167	dihydroorotate dehydrogenase activity
L0Z56_06180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L0Z56_06225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L0Z56_06235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L0Z56_06240	COG0037	tRNA processing
L0Z56_06245	COG2885	chlorophyll binding
L0Z56_06260	COG0482	sulfurtransferase activity
L0Z56_06275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L0Z56_06290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L0Z56_06295	COG0493	'glutamate synthase
L0Z56_06295	COG0543	2 iron, 2 sulfur cluster binding
L0Z56_06315	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
L0Z56_06330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L0Z56_06340	COG0326	Molecular chaperone. Has ATPase activity
L0Z56_06350	COG0156	8-amino-7-oxononanoate synthase activity
L0Z56_06360	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L0Z56_06370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L0Z56_06375	COG2202	Pas domain
L0Z56_06375	COG2205	protein histidine kinase activity
L0Z56_06380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L0Z56_06385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L0Z56_06405	COG1295	ribonuclease BN
L0Z56_06410	COG1028	Short-chain dehydrogenase reductase Sdr
L0Z56_06420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L0Z56_06440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L0Z56_06445	COG1006	Multisubunit Na H antiporter MnhC subunit
L0Z56_06455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L0Z56_06455	COG2111	Na H antiporter
L0Z56_06480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L0Z56_06490	COG0567	Dehydrogenase, E1 component
L0Z56_06520	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L0Z56_06525	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L0Z56_06530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L0Z56_06535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L0Z56_06545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L0Z56_06555	COG0174	glutamine synthetase