locus-tag	class	description
NHG98_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NHG98_00025	COG3736	Type IV secretory pathway, component VirB8
NHG98_00040	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
NHG98_00045	COG3505	Type IV secretory pathway VirD4
NHG98_00055	COG2890	protein-(glutamine-N5) methyltransferase activity
NHG98_00065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NHG98_00075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NHG98_00080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NHG98_00090	COG0544	peptidyl-prolyl cis-trans isomerase activity
NHG98_00120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NHG98_00140	COG0450	alkyl hydroperoxide reductase
NHG98_00160	COG4974	Belongs to the 'phage' integrase family
NHG98_00185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NHG98_00195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NHG98_00200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NHG98_00215	COG0250	Participates in transcription elongation, termination and antitermination
NHG98_00220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NHG98_00225	COG0081	regulation of translation
NHG98_00230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NHG98_00235	COG0222	ribosome binding
NHG98_00240	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NHG98_00240	COG0085	RNA polymerase activity
NHG98_00245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NHG98_00255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NHG98_00280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NHG98_00300	COG2003	Belongs to the UPF0758 family
NHG98_00375	COG2070	2-Nitropropane dioxygenase
NHG98_00390	COG3451	type IV secretory pathway VirB4
NHG98_00415	COG0508	dehydrogenase complex catalyzes the overall conversion of
NHG98_00430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NHG98_00445	COG3118	belongs to the thioredoxin family
NHG98_00455	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
NHG98_00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NHG98_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NHG98_00470	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NHG98_00485	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NHG98_00490	COG0539	negative regulation of cytoplasmic translation
NHG98_00495	COG0776	regulation of translation
NHG98_00510	COG0750	zinc metalloprotease
NHG98_00530	COG0543	2 iron, 2 sulfur cluster binding
NHG98_00530	COG0493	'glutamate synthase
NHG98_00540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NHG98_00550	COG0124	histidyl-tRNA synthetase
NHG98_00560	COG0484	heat shock protein binding
NHG98_00585	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NHG98_00590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NHG98_00590	COG2857	Cytochrome c1
NHG98_00595	COG0556	nucleotide-excision repair
NHG98_00630	COG0330	HflC and HflK could
NHG98_00720	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NHG98_00730	COG0142	geranyltranstransferase activity
NHG98_00735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NHG98_00740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NHG98_00745	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NHG98_00750	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
NHG98_00775	COG0484	heat shock protein binding
NHG98_00780	COG0285	dihydrofolate synthase activity
NHG98_00795	COG2867	negative regulation of translational initiation
NHG98_00830	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NHG98_00835	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NHG98_00850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NHG98_00885	COG0723	plastoquinol--plastocyanin reductase activity
NHG98_00890	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NHG98_00965	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NHG98_00975	COG0114	fumarate hydratase activity
NHG98_00985	COG1104	cysteine desulfurase activity
NHG98_00990	COG2945	thiolester hydrolase activity
NHG98_01005	COG0316	Belongs to the HesB IscA family
NHG98_01010	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NHG98_01015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NHG98_01015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NHG98_01025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NHG98_01035	COG1185	polyribonucleotide nucleotidyltransferase activity
NHG98_01045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NHG98_01055	COG2171	N-acyltransferase activity
NHG98_01105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NHG98_01110	COG0047	phosphoribosylformylglycinamidine synthase activity
NHG98_01115	COG0581	inorganic phosphate transmembrane transporter activity
NHG98_01135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NHG98_01150	COG1253	flavin adenine dinucleotide binding
NHG98_01160	COG0436	Aminotransferase
NHG98_01175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NHG98_01190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NHG98_01200	COG4770	biotin carboxylase activity
NHG98_01225	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NHG98_01230	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NHG98_01245	COG0072	phenylalanine-tRNA ligase activity
NHG98_01245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NHG98_01255	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NHG98_01265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NHG98_01280	COG1981	membrane
NHG98_01285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NHG98_01315	COG0567	Dehydrogenase, E1 component
NHG98_01340	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NHG98_01345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NHG98_01360	COG0167	dihydroorotate dehydrogenase activity
NHG98_01370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NHG98_01405	COG0626	cystathionine gamma-synthase activity
NHG98_01420	COG1530	ribonuclease E activity
NHG98_01425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NHG98_01445	COG1121	(ABC) transporter
NHG98_01450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NHG98_01465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NHG98_01480	COG0508	dehydrogenase complex catalyzes the overall conversion of
NHG98_01480	COG0022	dehydrogenase e1 component
NHG98_01495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NHG98_01495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NHG98_01530	COG0573	inorganic phosphate transmembrane transporter activity
NHG98_01540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NHG98_01550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NHG98_01570	COG0149	triose-phosphate isomerase activity
NHG98_01575	COG0758	DNA mediated transformation
NHG98_01580	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NHG98_01600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NHG98_01615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NHG98_01625	COG1034	ATP synthesis coupled electron transport
NHG98_01630	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NHG98_01635	COG0113	porphobilinogen synthase activity
NHG98_01645	COG0752	glycyl-tRNA synthetase alpha subunit
NHG98_01650	COG0751	glycine-tRNA ligase activity
NHG98_01680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NHG98_01690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NHG98_01700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NHG98_01705	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NHG98_01715	COG1845	cytochrome c oxidase, subunit III
NHG98_01725	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NHG98_01745	COG0768	penicillin binding
NHG98_01755	COG0606	chelatase, subunit chli
NHG98_01785	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NHG98_01800	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NHG98_01810	COG0745	RESPONSE REGULATOR receiver
NHG98_01825	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
NHG98_01830	COG0343	queuine tRNA-ribosyltransferase activity
NHG98_01840	COG0612	Peptidase, M16
NHG98_01845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NHG98_01865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NHG98_01870	COG0670	Belongs to the BI1 family
NHG98_01875	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
NHG98_01915	COG0084	hydrolase, TatD family'
NHG98_01925	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NHG98_01935	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NHG98_01940	COG0537	adenosine 5'-monophosphoramidase activity
NHG98_01955	COG1090	epimerase
NHG98_01980	COG0187	DNA topoisomerase II activity
NHG98_01990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NHG98_02010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NHG98_02025	COG0326	Molecular chaperone. Has ATPase activity
NHG98_02035	COG0156	8-amino-7-oxononanoate synthase activity
NHG98_02055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NHG98_02060	COG2202	Pas domain
NHG98_02060	COG2205	protein histidine kinase activity
NHG98_02070	COG0776	regulation of translation
NHG98_02085	COG0495	leucyl-tRNA aminoacylation
NHG98_02095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NHG98_02100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NHG98_02105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NHG98_02105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NHG98_02135	COG0312	modulator of DNA gyrase
NHG98_02145	COG0372	Belongs to the citrate synthase family
NHG98_02160	COG4974	Belongs to the 'phage' integrase family
NHG98_02175	COG0628	permease
NHG98_02185	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NHG98_02185	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NHG98_02210	COG4133	protoheme IX ABC transporter activity
NHG98_02225	COG3757	hydrolase, family 25
NHG98_02230	COG0477	Major facilitator Superfamily
NHG98_02235	COG0564	pseudouridine synthase activity
NHG98_02245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NHG98_02245	COG0574	Belongs to the PEP-utilizing enzyme family
NHG98_02255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NHG98_02330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NHG98_02335	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NHG98_02355	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NHG98_02410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NHG98_02425	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
NHG98_02440	COG0543	2 iron, 2 sulfur cluster binding
NHG98_02440	COG0493	'glutamate synthase
NHG98_02460	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NHG98_02485	COG2885	chlorophyll binding
NHG98_02495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NHG98_02530	COG3346	SURF1 family
NHG98_02545	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NHG98_02555	COG0445	tRNA wobble uridine modification
NHG98_02590	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NHG98_02595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NHG98_02605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NHG98_02625	COG0531	amino acid
NHG98_02630	COG0531	amino acid
NHG98_02640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NHG98_02645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NHG98_02660	COG1178	ABC-type Fe3 transport system permease component
NHG98_02665	COG1054	Belongs to the UPF0176 family
NHG98_02695	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NHG98_02695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NHG98_02700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NHG98_02720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NHG98_02730	COG0575	Belongs to the CDS family
NHG98_02735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NHG98_02750	COG0528	UMP kinase activity
NHG98_02760	COG0052	Belongs to the universal ribosomal protein uS2 family
NHG98_02770	COG1862	Preprotein translocase
NHG98_02805	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NHG98_02815	COG0612	Peptidase, M16
NHG98_02820	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NHG98_02825	COG0196	riboflavin kinase activity
NHG98_02845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NHG98_02855	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NHG98_02905	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NHG98_02915	COG1127	ABC transporter
NHG98_02920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NHG98_02955	COG3344	reverse transcriptase
NHG98_02980	COG0739	heme binding
NHG98_02985	COG0217	transcriptional regulatory protein
NHG98_02990	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NHG98_03000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NHG98_03005	COG0281	malic enzyme
NHG98_03005	COG0280	phosphate acetyltransferase
NHG98_03025	COG0358	DNA primase activity
NHG98_03030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NHG98_03115	COG4804	nuclease activity
NHG98_03320	COG0237	dephospho-CoA kinase activity
NHG98_03365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NHG98_03390	COG0305	Participates in initiation and elongation during chromosome replication
NHG98_03400	COG1714	RDD family
NHG98_03405	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
NHG98_03415	COG3451	type IV secretory pathway VirB4
NHG98_03420	COG3704	protein secretion by the type IV secretion system
NHG98_03425	COG3704	protein secretion by the type IV secretion system
NHG98_03430	COG3704	protein secretion by the type IV secretion system
NHG98_03445	COG0742	ribosomal rna small subunit methyltransferase
NHG98_03465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NHG98_03485	COG4235	cytochrome complex assembly
NHG98_03485	COG3088	subunit of a heme lyase
NHG98_03495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NHG98_03505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NHG98_03510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NHG98_03515	COG0629	single-stranded DNA binding
NHG98_03550	COG2827	Endonuclease containing a URI domain
NHG98_03555	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NHG98_03585	COG2009	succinate dehydrogenase
NHG98_03590	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NHG98_03600	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
NHG98_03600	COG0662	Cupin 2, conserved barrel domain protein
NHG98_03615	COG4591	ABC-type transport system involved in lipoprotein release permease component
NHG98_03630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NHG98_03635	COG0312	modulator of DNA gyrase
NHG98_03640	COG1278	Cold shock
NHG98_03645	COG0513	Belongs to the DEAD box helicase family
NHG98_03655	COG1830	Aldolase
NHG98_03670	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NHG98_03685	COG0552	protein localization to endoplasmic reticulum
NHG98_03690	COG0822	iron-sulfur transferase activity
NHG98_03695	COG0316	Belongs to the HesB IscA family
NHG98_03710	COG0681	Belongs to the peptidase S26 family
NHG98_03715	COG0126	phosphoglycerate kinase activity
NHG98_03725	COG0564	pseudouridine synthase activity
NHG98_03735	COG2333	competence protein COMEC
NHG98_03735	COG0658	competence protein
NHG98_03780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NHG98_03805	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NHG98_03815	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NHG98_03820	COG0254	rRNA binding
NHG98_03825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NHG98_03845	COG0492	ferredoxin-NADP+ reductase activity
NHG98_03855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NHG98_03860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NHG98_03865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NHG98_03870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NHG98_03875	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NHG98_03905	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NHG98_03915	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NHG98_03915	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NHG98_03920	COG1007	ATP synthesis coupled electron transport
NHG98_03925	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NHG98_03930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NHG98_03935	COG0713	ATP synthesis coupled electron transport
NHG98_03940	COG0839	Belongs to the complex I subunit 6 family
NHG98_03965	COG3474	cytochrome
NHG98_03970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NHG98_03985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NHG98_03990	COG0359	binds to the 23S rRNA
NHG98_04000	COG0360	Binds together with S18 to 16S ribosomal RNA
NHG98_04015	COG1104	cysteine desulfurase activity
NHG98_04030	COG0321	lipoyl(octanoyl) transferase activity
NHG98_04035	COG4695	Portal protein
NHG98_04045	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NHG98_04080	COG0525	valine-tRNA ligase activity
NHG98_04100	COG0284	orotidine-5'-phosphate decarboxylase activity
NHG98_04120	COG1322	Protein conserved in bacteria
NHG98_04155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NHG98_04170	COG1074	ATP-dependent DNA helicase activity
NHG98_04190	COG2003	Belongs to the UPF0758 family
NHG98_04205	COG1686	Belongs to the peptidase S11 family
NHG98_04215	COG2076	Multidrug Resistance protein
NHG98_04235	COG2239	Acts as a magnesium transporter
NHG98_04245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NHG98_04280	COG2814	Major facilitator Superfamily
NHG98_04290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NHG98_04315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NHG98_04320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NHG98_04345	COG0018	arginyl-trna synthetase
NHG98_04355	COG1132	(ABC) transporter
NHG98_04365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NHG98_04370	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NHG98_04375	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NHG98_04405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NHG98_04440	COG0823	Involved in the tonB-independent uptake of proteins
NHG98_04470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NHG98_04485	COG1253	flavin adenine dinucleotide binding
NHG98_04505	COG0653	protein targeting
NHG98_04540	COG1115	amino acid carrier protein
NHG98_04555	COG0459	protein refolding
NHG98_04565	COG0354	folic acid binding
NHG98_04570	COG0756	dUTP diphosphatase activity
NHG98_04605	COG3577	Aspartyl protease
NHG98_04615	COG1138	Cytochrome C-type biogenesis protein
NHG98_04630	COG1301	dicarboxylic acid transport
NHG98_04635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NHG98_04640	COG1217	gtp-binding protein TYPA
NHG98_04680	COG0666	response to abiotic stimulus
NHG98_04715	COG2801	Transposase and inactivated derivatives
NHG98_04720	COG0632	four-way junction helicase activity
NHG98_04725	COG2255	four-way junction helicase activity
NHG98_04750	COG2094	Belongs to the DNA glycosylase MPG family
NHG98_04755	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NHG98_04760	COG0772	Belongs to the SEDS family
NHG98_04765	COG0651	ATP synthesis coupled electron transport
NHG98_04785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NHG98_04790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NHG98_04795	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
NHG98_04805	COG1160	GTP binding
NHG98_04815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NHG98_04840	COG0259	pyridoxamine-phosphate oxidase activity
NHG98_04850	COG1840	ABC-type Fe3 transport system, periplasmic component
NHG98_04865	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NHG98_04880	COG0228	four-way junction DNA binding
NHG98_04885	COG0142	geranyltranstransferase activity
NHG98_04915	COG0504	CTP synthase activity
NHG98_04925	COG0590	tRNA wobble adenosine to inosine editing
NHG98_04960	COG1295	ribonuclease BN
NHG98_04965	COG4221	oxidoreductase activity
NHG98_04985	COG3842	ATPase activity
NHG98_04990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NHG98_05000	COG3932	Exopolysaccharide synthesis, ExoD
NHG98_05045	COG1494	fructose-1,6-bisphosphatase
NHG98_05070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NHG98_05080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NHG98_05095	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NHG98_05110	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NHG98_05145	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NHG98_05155	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NHG98_05165	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NHG98_05175	COG0201	protein transport
NHG98_05185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NHG98_05195	COG0202	RNA polymerase activity
NHG98_05205	COG0792	nuclease activity
NHG98_05210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NHG98_05220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NHG98_05245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NHG98_05260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NHG98_05265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NHG98_05275	COG0328	RNA-DNA hybrid ribonuclease activity
NHG98_05295	COG0805	protein transport
NHG98_05315	COG0617	tRNA 3'-terminal CCA addition
NHG98_05325	COG0012	GTP binding
NHG98_05340	COG0194	GDP metabolic process
NHG98_05350	COG1053	succinate dehydrogenase
NHG98_05355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NHG98_05360	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NHG98_05380	COG0193	aminoacyl-tRNA hydrolase activity
NHG98_05400	COG0275	rRNA processing
NHG98_05405	COG0477	Major facilitator Superfamily
NHG98_05410	COG0024	Methionine aminopeptidase
NHG98_05425	COG0242	peptide deformylase activity
NHG98_05430	COG1573	uracil-dna glycosylase
NHG98_05500	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NHG98_05530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NHG98_05535	COG0508	dehydrogenase complex catalyzes the overall conversion of
NHG98_05545	COG0477	Major facilitator Superfamily
NHG98_05595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NHG98_05600	COG1006	Multisubunit Na H antiporter MnhC subunit
NHG98_05610	COG2111	Na H antiporter
NHG98_05610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NHG98_05635	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NHG98_05675	COG0651	ATP synthesis coupled electron transport
NHG98_05695	COG0009	L-threonylcarbamoyladenylate synthase
NHG98_05705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NHG98_05715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NHG98_05800	COG0235	Class ii aldolase
NHG98_05805	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NHG98_05835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NHG98_05870	COG2902	Dehydrogenase
NHG98_05875	COG0542	response to heat
NHG98_05890	COG0649	NAD binding
NHG98_05895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NHG98_05900	COG0527	aspartate kinase activity
NHG98_05950	COG0473	3-isopropylmalate dehydrogenase activity
NHG98_05965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NHG98_05980	COG0101	tRNA pseudouridine synthase activity
NHG98_05985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NHG98_05995	COG1183	phosphatidylcholine synthase activity
NHG98_06000	COG1115	amino acid carrier protein
NHG98_06005	COG1115	amino acid carrier protein
NHG98_06015	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NHG98_06025	COG1230	cation diffusion facilitator family transporter
NHG98_06060	COG1475	DNA binding
NHG98_06085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NHG98_06125	COG1268	BioY protein
NHG98_06140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NHG98_06145	COG4536	flavin adenine dinucleotide binding
NHG98_06150	COG3750	Belongs to the UPF0335 family
NHG98_06155	COG0163	prenyltransferase activity
NHG98_06180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NHG98_06195	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NHG98_06200	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NHG98_06205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NHG98_06215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NHG98_06225	COG0174	glutamine synthetase
NHG98_06250	COG0305	Participates in initiation and elongation during chromosome replication
NHG98_06340	COG0792	nuclease activity