locus-tag	class	description
CAI20_00030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CAI20_00085	COG0138	bifunctional purine biosynthesis protein purh
CAI20_00100	COG0473	3-isopropylmalate dehydrogenase activity
CAI20_00115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CAI20_00130	COG0085	RNA polymerase activity
CAI20_00130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CAI20_00140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CAI20_00145	COG0081	regulation of translation
CAI20_00150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CAI20_00155	COG0250	Participates in transcription elongation, termination and antitermination
CAI20_00170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CAI20_00175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CAI20_00180	COG0049	tRNA binding
CAI20_00185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CAI20_00190	COG2890	protein-(glutamine-N5) methyltransferase activity
CAI20_00190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CAI20_00215	COG0544	peptidyl-prolyl cis-trans isomerase activity
CAI20_00220	COG0740	serine-type endopeptidase activity
CAI20_00225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CAI20_00230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CAI20_00235	COG0768	penicillin binding
CAI20_00240	COG0726	polysaccharide deacetylase
CAI20_00245	COG0606	chelatase, subunit chli
CAI20_00265	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CAI20_00270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CAI20_00285	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CAI20_00290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CAI20_00295	COG0745	RESPONSE REGULATOR receiver
CAI20_00310	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CAI20_00315	COG0343	queuine tRNA-ribosyltransferase activity
CAI20_00325	COG0612	Peptidase, M16
CAI20_00330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CAI20_00340	COG0742	ribosomal rna small subunit methyltransferase
CAI20_00355	COG3704	protein secretion by the type IV secretion system
CAI20_00355	COG1340	protein secretion by the type IV secretion system
CAI20_00360	COG3704	protein secretion by the type IV secretion system
CAI20_00365	COG3704	protein secretion by the type IV secretion system
CAI20_00370	COG3451	type IV secretory pathway VirB4
CAI20_00380	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CAI20_00390	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CAI20_00395	COG3827	peptidoglycan binding
CAI20_00405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CAI20_00420	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CAI20_00430	COG0071	Belongs to the small heat shock protein (HSP20) family
CAI20_00435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAI20_00445	COG0439	Biotin carboxylase
CAI20_00450	COG1612	heme a metabolic process
CAI20_00455	COG1215	transferase activity, transferring glycosyl groups
CAI20_00470	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CAI20_00475	COG0356	it plays a direct role in the translocation of protons across the membrane
CAI20_00485	COG0072	phenylalanine-tRNA ligase activity
CAI20_00485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAI20_00495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CAI20_00505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAI20_00510	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CAI20_00515	COG0649	NAD binding
CAI20_00525	COG2070	2-Nitropropane dioxygenase
CAI20_00540	COG3451	type IV secretory pathway VirB4
CAI20_00550	COG0666	response to abiotic stimulus
CAI20_00570	COG0006	proline dipeptidase activity
CAI20_00575	COG0445	tRNA wobble uridine modification
CAI20_00590	COG0728	peptidoglycan biosynthetic process
CAI20_00615	COG4695	Portal protein
CAI20_00620	COG0321	lipoyl(octanoyl) transferase activity
CAI20_00625	COG1619	proteins homologs of microcin C7 resistance protein MccF
CAI20_00650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CAI20_00655	COG0359	binds to the 23S rRNA
CAI20_00660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CAI20_00665	COG0360	Binds together with S18 to 16S ribosomal RNA
CAI20_00670	COG0587	DNA-directed DNA polymerase activity
CAI20_00685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CAI20_00690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CAI20_00695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CAI20_00715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CAI20_00730	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CAI20_00735	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CAI20_00740	COG0254	rRNA binding
CAI20_00745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CAI20_00755	COG1840	ABC-type Fe3 transport system, periplasmic component
CAI20_00760	COG0540	Belongs to the ATCase OTCase family
CAI20_00780	COG0194	GDP metabolic process
CAI20_00790	COG1053	succinate dehydrogenase
CAI20_00800	COG2171	N-acyltransferase activity
CAI20_00845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAI20_00850	COG0371	Dehydrogenase
CAI20_00880	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CAI20_00925	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CAI20_00980	COG1178	ABC-type Fe3 transport system permease component
CAI20_00985	COG2967	ApaG domain
CAI20_00990	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CAI20_00995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CAI20_01005	COG1113	amino acid transport
CAI20_01010	COG0531	amino acid
CAI20_01020	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CAI20_01025	COG0124	histidyl-tRNA synthetase
CAI20_01035	COG0484	heat shock protein binding
CAI20_01060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CAI20_01065	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CAI20_01065	COG2857	Cytochrome c1
CAI20_01070	COG0556	nucleotide-excision repair
CAI20_01080	COG0776	regulation of translation
CAI20_01095	COG0495	leucyl-tRNA aminoacylation
CAI20_01110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CAI20_01115	COG0163	prenyltransferase activity
CAI20_01120	COG3750	Belongs to the UPF0335 family
CAI20_01125	COG4536	flavin adenine dinucleotide binding
CAI20_01130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAI20_01135	COG0105	UTP biosynthetic process
CAI20_01145	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CAI20_01160	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CAI20_01165	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CAI20_01180	COG0142	geranyltranstransferase activity
CAI20_01185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAI20_01190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAI20_01195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CAI20_01200	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CAI20_01250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CAI20_01265	COG0326	Molecular chaperone. Has ATPase activity
CAI20_01280	COG0156	8-amino-7-oxononanoate synthase activity
CAI20_01290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CAI20_01295	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CAI20_01305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAI20_01310	COG2205	protein histidine kinase activity
CAI20_01320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CAI20_01340	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAI20_01355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CAI20_01360	COG0037	tRNA processing
CAI20_01365	COG2885	chlorophyll binding
CAI20_01380	COG0482	sulfurtransferase activity
CAI20_01390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CAI20_01400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAI20_01405	COG0493	'glutamate synthase
CAI20_01405	COG0543	2 iron, 2 sulfur cluster binding
CAI20_01425	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CAI20_01435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CAI20_01460	COG0629	single-stranded DNA binding
CAI20_01465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAI20_01480	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CAI20_01485	COG0670	Belongs to the BI1 family
CAI20_01490	COG1104	cysteine desulfurase activity
CAI20_01495	COG2945	thiolester hydrolase activity
CAI20_01510	COG0316	Belongs to the HesB IscA family
CAI20_01515	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CAI20_01520	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAI20_01520	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAI20_01530	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CAI20_01535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CAI20_01545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CAI20_01560	COG0126	phosphoglycerate kinase activity
CAI20_01565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CAI20_01580	COG2076	Multidrug Resistance protein
CAI20_01590	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CAI20_01595	COG1253	flavin adenine dinucleotide binding
CAI20_01625	COG0772	Belongs to the SEDS family
CAI20_01630	COG1104	cysteine desulfurase activity
CAI20_01655	COG0697	spore germination
CAI20_01680	COG1132	(ABC) transporter
CAI20_01700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAI20_01705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CAI20_01745	COG3344	reverse transcriptase
CAI20_01765	COG0492	ferredoxin-NADP+ reductase activity
CAI20_01775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CAI20_01780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI20_01790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CAI20_01795	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CAI20_01800	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CAI20_01830	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CAI20_01835	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CAI20_01835	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CAI20_01845	COG1007	ATP synthesis coupled electron transport
CAI20_01850	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI20_01855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CAI20_01860	COG0713	ATP synthesis coupled electron transport
CAI20_01865	COG0839	Belongs to the complex I subunit 6 family
CAI20_01885	COG3474	cytochrome
CAI20_01890	COG0632	four-way junction helicase activity
CAI20_01895	COG2255	four-way junction helicase activity
CAI20_01915	COG0372	Belongs to the citrate synthase family
CAI20_01920	COG0268	Binds directly to 16S ribosomal RNA
CAI20_01930	COG4974	Belongs to the 'phage' integrase family
CAI20_01955	COG0628	permease
CAI20_01965	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CAI20_01965	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CAI20_01970	COG1475	DNA binding
CAI20_01975	COG1192	Involved in chromosome partitioning
CAI20_02005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CAI20_02020	COG0045	succinate-CoA ligase (ADP-forming) activity
CAI20_02045	COG1268	BioY protein
CAI20_02070	COG0723	plastoquinol--plastocyanin reductase activity
CAI20_02075	COG0312	modulator of DNA gyrase
CAI20_02095	COG0285	dihydrofolate synthase activity
CAI20_02110	COG2867	negative regulation of translational initiation
CAI20_02115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CAI20_02150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CAI20_02155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CAI20_02165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAI20_02175	COG0592	DNA-directed DNA polymerase activity
CAI20_02180	COG0101	tRNA pseudouridine synthase activity
CAI20_02185	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CAI20_02190	COG0193	aminoacyl-tRNA hydrolase activity
CAI20_02195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CAI20_02215	COG0275	rRNA processing
CAI20_02225	COG0024	Methionine aminopeptidase
CAI20_02230	COG0849	cell division
CAI20_02235	COG0242	peptide deformylase activity
CAI20_02240	COG1573	uracil-dna glycosylase
CAI20_02255	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CAI20_02270	COG1295	ribonuclease BN
CAI20_02275	COG1028	Short-chain dehydrogenase reductase Sdr
CAI20_02280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CAI20_02290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CAI20_02295	COG0564	pseudouridine synthase activity
CAI20_02305	COG0658	competence protein
CAI20_02305	COG2333	competence protein COMEC
CAI20_02315	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CAI20_02335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CAI20_02340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CAI20_02350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CAI20_02360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAI20_02385	COG1160	GTP binding
CAI20_02395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAI20_02425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CAI20_02430	COG0259	pyridoxamine-phosphate oxidase activity
CAI20_02435	COG0047	phosphoribosylformylglycinamidine synthase activity
CAI20_02440	COG0581	inorganic phosphate transmembrane transporter activity
CAI20_02445	COG0335	large ribosomal subunit rRNA binding
CAI20_02450	COG0336	Belongs to the RNA methyltransferase TrmD family
CAI20_02455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CAI20_02460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CAI20_02480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CAI20_02495	COG2094	Belongs to the DNA glycosylase MPG family
CAI20_02500	COG0489	protein tyrosine kinase activity
CAI20_02520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CAI20_02525	COG0799	negative regulation of ribosome biogenesis
CAI20_02535	COG0494	nUDIX hydrolase
CAI20_02540	COG0084	hydrolase, TatD family'
CAI20_02545	COG0039	L-malate dehydrogenase activity
CAI20_02550	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI20_02555	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI20_02560	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAI20_02565	COG0537	adenosine 5'-monophosphoramidase activity
CAI20_02585	COG1090	epimerase
CAI20_02595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAI20_02600	COG0416	fatty acid biosynthetic process
CAI20_02605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CAI20_02610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAI20_02615	COG3842	ATPase activity
CAI20_02620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CAI20_02630	COG0493	'glutamate synthase
CAI20_02630	COG0543	2 iron, 2 sulfur cluster binding
CAI20_02635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAI20_02650	COG0750	zinc metalloprotease
CAI20_02665	COG0776	regulation of translation
CAI20_02670	COG0539	negative regulation of cytoplasmic translation
CAI20_02675	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CAI20_02715	COG0330	HflC and HflK could
CAI20_02735	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CAI20_02745	COG1758	RNA polymerase activity
CAI20_02755	COG1320	monovalent cation:proton antiporter activity
CAI20_02760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CAI20_02760	COG2111	Na H antiporter
CAI20_02770	COG1006	Multisubunit Na H antiporter MnhC subunit
CAI20_02775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAI20_02805	COG2009	succinate dehydrogenase
CAI20_02810	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CAI20_02840	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CAI20_02845	COG0312	modulator of DNA gyrase
CAI20_02850	COG1278	Cold shock
CAI20_02860	COG0542	response to heat
CAI20_02870	COG1830	Aldolase
CAI20_02885	COG0167	dihydroorotate dehydrogenase activity
CAI20_02890	COG0571	ribonuclease III activity
CAI20_02900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CAI20_02910	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CAI20_02915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CAI20_02930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CAI20_02940	COG1034	ATP synthesis coupled electron transport
CAI20_02950	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CAI20_02955	COG0113	porphobilinogen synthase activity
CAI20_02980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAI20_02980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAI20_02985	COG0154	amidase activity
CAI20_02990	COG0187	DNA topoisomerase II activity
CAI20_03005	COG0688	phosphatidylethanolamine metabolic process
CAI20_03010	COG1183	phosphatidylcholine synthase activity
CAI20_03030	COG1115	amino acid carrier protein
CAI20_03035	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CAI20_03045	COG1230	cation diffusion facilitator family transporter
CAI20_03075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAI20_03085	COG0322	excinuclease ABC activity
CAI20_03090	COG0751	glycine-tRNA ligase activity
CAI20_03095	COG0752	glycyl-tRNA synthetase alpha subunit
CAI20_03145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAI20_03155	COG0307	riboflavin synthase, alpha
CAI20_03165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CAI20_03170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CAI20_03185	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CAI20_03190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CAI20_03200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CAI20_03205	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CAI20_03215	COG1845	cytochrome c oxidase, subunit III
CAI20_03220	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CAI20_03230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAI20_03230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CAI20_03260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CAI20_03265	COG0573	inorganic phosphate transmembrane transporter activity
CAI20_03270	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CAI20_03275	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CAI20_03285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CAI20_03315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CAI20_03320	COG0051	transcription antitermination factor activity, RNA binding
CAI20_03325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CAI20_03330	COG0088	Forms part of the polypeptide exit tunnel
CAI20_03340	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CAI20_03345	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CAI20_03350	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CAI20_03355	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CAI20_03360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CAI20_03365	COG0255	Belongs to the universal ribosomal protein uL29 family
CAI20_03370	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CAI20_03375	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CAI20_03380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CAI20_03385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CAI20_03390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CAI20_03395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CAI20_03400	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CAI20_03405	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CAI20_03410	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CAI20_03415	COG0200	Binds to the 23S rRNA
CAI20_03420	COG0201	protein transport
CAI20_03425	COG0563	adenylate kinase activity
CAI20_03430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CAI20_03435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CAI20_03440	COG0202	RNA polymerase activity
CAI20_03445	COG0203	ribosomal protein L17
CAI20_03450	COG0792	nuclease activity
CAI20_03455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CAI20_03460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CAI20_03465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAI20_03500	COG0574	Belongs to the PEP-utilizing enzyme family
CAI20_03500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CAI20_03515	COG1566	PFAM secretion protein HlyD family protein
CAI20_03520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CAI20_03530	COG0280	phosphate acetyltransferase
CAI20_03530	COG0281	malic enzyme
CAI20_03535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CAI20_03550	COG0217	transcriptional regulatory protein
CAI20_03555	COG0739	heme binding
CAI20_03585	COG2814	Major facilitator Superfamily
CAI20_03595	COG1132	(ABC) transporter
CAI20_03610	COG0018	arginyl-trna synthetase
CAI20_03615	COG4133	protoheme IX ABC transporter activity
CAI20_03630	COG0590	tRNA wobble adenosine to inosine editing
CAI20_03640	COG0504	CTP synthase activity
CAI20_03670	COG1862	Preprotein translocase
CAI20_03680	COG0052	Belongs to the universal ribosomal protein uS2 family
CAI20_03685	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CAI20_03690	COG0528	UMP kinase activity
CAI20_03695	COG0233	cytoplasmic translational termination
CAI20_03710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CAI20_03715	COG0717	Belongs to the dCTP deaminase family
CAI20_03740	COG3736	Type IV secretory pathway, component VirB8
CAI20_03755	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CAI20_03760	COG3505	Type IV secretory pathway VirD4
CAI20_03770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CAI20_03775	COG0477	Major facilitator Superfamily
CAI20_03780	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CAI20_03785	COG0552	protein localization to endoplasmic reticulum
CAI20_03790	COG0822	iron-sulfur transferase activity
CAI20_03795	COG0316	Belongs to the HesB IscA family
CAI20_03800	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CAI20_03810	COG0681	Belongs to the peptidase S26 family
CAI20_03820	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAI20_03820	COG0022	dehydrogenase e1 component
CAI20_03850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CAI20_03890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CAI20_03895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CAI20_03900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CAI20_03920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CAI20_03925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CAI20_03935	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CAI20_03940	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CAI20_03945	COG0823	Involved in the tonB-independent uptake of proteins
CAI20_03960	COG0484	heat shock protein binding
CAI20_03975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CAI20_03980	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CAI20_03995	COG0114	fumarate hydratase activity
CAI20_04035	COG3346	SURF1 family
CAI20_04050	COG0148	phosphopyruvate hydratase activity
CAI20_04055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CAI20_04080	COG1115	amino acid carrier protein
CAI20_04100	COG0459	protein refolding
CAI20_04105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CAI20_04130	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAI20_04155	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAI20_04170	COG0237	dephospho-CoA kinase activity
CAI20_04175	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CAI20_04190	COG1714	RDD family
CAI20_04200	COG0305	Participates in initiation and elongation during chromosome replication
CAI20_04220	COG0470	DNA polymerase III
CAI20_04225	COG0009	L-threonylcarbamoyladenylate synthase
CAI20_04235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CAI20_04245	COG0626	cystathionine gamma-synthase activity
CAI20_04250	COG0271	Belongs to the BolA IbaG family
CAI20_04255	COG0443	Heat shock 70 kDa protein
CAI20_04260	COG1530	ribonuclease E activity
CAI20_04265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CAI20_04280	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CAI20_04285	COG1121	(ABC) transporter
CAI20_04290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAI20_04305	COG0450	alkyl hydroperoxide reductase
CAI20_04325	COG0805	protein transport
CAI20_04360	COG0617	tRNA 3'-terminal CCA addition
CAI20_04370	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CAI20_04370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAI20_04395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CAI20_04410	COG1074	ATP-dependent DNA helicase activity
CAI20_04415	COG3088	subunit of a heme lyase
CAI20_04430	COG0484	heat shock protein binding
CAI20_04440	COG0358	DNA primase activity
CAI20_04445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAI20_04465	COG3316	Transposase and inactivated derivatives
CAI20_04475	COG1494	fructose-1,6-bisphosphatase
CAI20_04490	COG3842	ATPase activity
CAI20_04495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAI20_04505	COG3932	Exopolysaccharide synthesis, ExoD
CAI20_04510	COG0215	cysteine-tRNA ligase activity
CAI20_04530	COG0109	protoheme IX farnesyltransferase activity
CAI20_04540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CAI20_04545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAI20_04555	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CAI20_04560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CAI20_04570	COG4974	Belongs to the 'phage' integrase family
CAI20_04585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAI20_04595	COG0525	valine-tRNA ligase activity
CAI20_04610	COG0284	orotidine-5'-phosphate decarboxylase activity
CAI20_04630	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CAI20_04645	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CAI20_04685	COG0736	holo-[acyl-carrier-protein] synthase activity
CAI20_04715	COG0756	dUTP diphosphatase activity
CAI20_04730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CAI20_04740	COG3577	Aspartyl protease
CAI20_04750	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CAI20_04755	COG0174	glutamine synthetase
CAI20_04765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAI20_04775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CAI20_04780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CAI20_04785	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CAI20_04815	COG2239	Acts as a magnesium transporter
CAI20_04820	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CAI20_04840	COG0758	DNA mediated transformation
CAI20_04845	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CAI20_04865	COG1181	Belongs to the D-alanine--D-alanine ligase family
CAI20_04890	COG0564	pseudouridine synthase activity
CAI20_04900	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CAI20_04920	COG1138	Cytochrome C-type biogenesis protein
CAI20_04930	COG2003	Belongs to the UPF0758 family
CAI20_04935	COG1686	Belongs to the peptidase S11 family
CAI20_04940	COG1322	Protein conserved in bacteria
CAI20_05010	COG3316	Transposase and inactivated derivatives
CAI20_05085	COG0653	protein targeting
CAI20_05115	COG3316	Transposase and inactivated derivatives
CAI20_05135	COG3316	Transposase and inactivated derivatives
CAI20_05160	COG3316	Transposase and inactivated derivatives
CAI20_05170	COG0666	response to abiotic stimulus
CAI20_05175	COG3316	Transposase and inactivated derivatives
CAI20_05205	COG1381	Involved in DNA repair and RecF pathway recombination
CAI20_05210	COG3706	GGDEF domain
CAI20_05210	COG0745	RESPONSE REGULATOR receiver
CAI20_05220	COG2902	Dehydrogenase
CAI20_05225	COG0542	response to heat
CAI20_05235	COG3316	Transposase and inactivated derivatives
CAI20_05250	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CAI20_05270	COG4133	protoheme IX ABC transporter activity
CAI20_05275	COG0018	arginyl-trna synthetase
CAI20_05310	COG1132	(ABC) transporter
CAI20_05315	COG3316	Transposase and inactivated derivatives
CAI20_05365	COG3316	Transposase and inactivated derivatives
CAI20_05395	COG3316	Transposase and inactivated derivatives
CAI20_05410	COG0235	Class ii aldolase
CAI20_05425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CAI20_05430	COG0484	heat shock protein binding
CAI20_05435	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CAI20_05450	COG1674	ftsk spoiiie
CAI20_05475	COG0424	maF-like protein
CAI20_05490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CAI20_05500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CAI20_05505	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CAI20_05510	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CAI20_05535	COG3316	Transposase and inactivated derivatives
CAI20_05565	COG3316	Transposase and inactivated derivatives
CAI20_05570	COG2814	Major facilitator Superfamily
CAI20_05580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CAI20_05590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAI20_05615	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CAI20_05625	COG0575	Belongs to the CDS family
CAI20_05630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CAI20_05635	COG3316	Transposase and inactivated derivatives
CAI20_05670	COG3316	Transposase and inactivated derivatives
CAI20_05700	COG3316	Transposase and inactivated derivatives
CAI20_05715	COG3316	Transposase and inactivated derivatives
CAI20_05725	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAI20_05750	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CAI20_05760	COG0012	GTP binding
CAI20_05770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CAI20_05790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CAI20_05795	COG1301	dicarboxylic acid transport
CAI20_05805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CAI20_05820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAI20_05830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAI20_05855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CAI20_05865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CAI20_05870	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CAI20_05875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAI20_05885	COG1450	Type ii and iii secretion system protein
CAI20_05890	COG0519	Catalyzes the synthesis of GMP from XMP
CAI20_05890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAI20_05910	COG0481	GTPase activity
CAI20_05925	COG0196	riboflavin kinase activity
CAI20_05930	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CAI20_05935	COG0612	Peptidase, M16
CAI20_05945	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CAI20_05975	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CAI20_05980	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CAI20_05995	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CAI20_06025	COG0567	Dehydrogenase, E1 component
CAI20_06040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CAI20_06045	COG0142	geranyltranstransferase activity
CAI20_06050	COG0228	four-way junction DNA binding
CAI20_06055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAI20_06070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CAI20_06080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CAI20_06090	COG0149	triose-phosphate isomerase activity
CAI20_06200	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CAI20_06340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAI20_06365	COG2003	Belongs to the UPF0758 family
CAI20_06400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)