locus-tag	class	description
WCLE_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WCLE_00050	COG3736	Type IV secretory pathway, component VirB8
WCLE_00080	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
WCLE_00090	COG3505	Type IV secretory pathway VirD4
WCLE_001000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WCLE_001010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WCLE_001010	COG2857	Cytochrome c1
WCLE_001020	COG0556	nucleotide-excision repair
WCLE_001030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WCLE_001060	COG0758	DNA mediated transformation
WCLE_001070	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WCLE_001130	COG0495	leucyl-tRNA aminoacylation
WCLE_001150	COG0473	3-isopropylmalate dehydrogenase activity
WCLE_001340	COG0330	HflC and HflK could
WCLE_001410	COG0666	response to abiotic stimulus
WCLE_001420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WCLE_001440	COG0305	Participates in initiation and elongation during chromosome replication
WCLE_001460	COG1714	RDD family
WCLE_001470	COG1074	ATP-dependent DNA helicase activity
WCLE_001480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WCLE_001500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WCLE_001520	COG0756	dUTP diphosphatase activity
WCLE_001540	COG0728	peptidoglycan biosynthetic process
WCLE_001620	COG0752	glycyl-tRNA synthetase alpha subunit
WCLE_001630	COG0751	glycine-tRNA ligase activity
WCLE_001640	COG0322	excinuclease ABC activity
WCLE_001650	COG4804	nuclease activity
WCLE_00170	COG0484	heat shock protein binding
WCLE_001730	COG0113	porphobilinogen synthase activity
WCLE_001760	COG0839	Belongs to the complex I subunit 6 family
WCLE_001770	COG0713	ATP synthesis coupled electron transport
WCLE_001780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WCLE_001790	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WCLE_00180	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WCLE_001800	COG1007	ATP synthesis coupled electron transport
WCLE_001830	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WCLE_001840	COG1127	ABC transporter
WCLE_001850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WCLE_001940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WCLE_001960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WCLE_001970	COG0049	tRNA binding
WCLE_001980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WCLE_001990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WCLE_002010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WCLE_002020	COG0088	Forms part of the polypeptide exit tunnel
WCLE_002040	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WCLE_002050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WCLE_002060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WCLE_002070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WCLE_002080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WCLE_002100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WCLE_002110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WCLE_002120	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WCLE_002130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WCLE_002140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WCLE_002150	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WCLE_002160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WCLE_002170	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WCLE_002180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WCLE_002190	COG0200	Binds to the 23S rRNA
WCLE_00220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WCLE_002200	COG0201	protein transport
WCLE_002220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WCLE_002230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WCLE_002240	COG0202	RNA polymerase activity
WCLE_002250	COG0203	ribosomal protein L17
WCLE_002260	COG0792	nuclease activity
WCLE_002440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WCLE_002450	COG0849	cell division
WCLE_002460	COG0242	peptide deformylase activity
WCLE_002470	COG1573	uracil-dna glycosylase
WCLE_002490	COG0477	Major facilitator Superfamily
WCLE_00250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WCLE_002510	COG0590	tRNA wobble adenosine to inosine editing
WCLE_002520	COG0504	CTP synthase activity
WCLE_002540	COG2003	Belongs to the UPF0758 family
WCLE_002580	COG0022	dehydrogenase e1 component
WCLE_002580	COG0508	dehydrogenase complex catalyzes the overall conversion of
WCLE_002590	COG2239	Acts as a magnesium transporter
WCLE_002600	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WCLE_002640	COG0351	phosphomethylpyrimidine kinase
WCLE_002690	COG0450	alkyl hydroperoxide reductase
WCLE_002720	COG4974	Belongs to the 'phage' integrase family
WCLE_002730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WCLE_002750	COG0187	DNA topoisomerase II activity
WCLE_002820	COG0543	2 iron, 2 sulfur cluster binding
WCLE_002820	COG0493	'glutamate synthase
WCLE_00290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WCLE_002960	COG0235	Class ii aldolase
WCLE_003020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WCLE_003060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WCLE_003070	COG0670	Belongs to the BI1 family
WCLE_003080	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WCLE_00310	COG0527	aspartate kinase activity
WCLE_003110	COG0626	cystathionine gamma-synthase activity
WCLE_003140	COG1530	ribonuclease E activity
WCLE_003150	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WCLE_003190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WCLE_003200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WCLE_003220	COG1686	Belongs to the peptidase S11 family
WCLE_003250	COG0617	tRNA 3'-terminal CCA addition
WCLE_003270	COG0012	GTP binding
WCLE_003290	COG1494	fructose-1,6-bisphosphatase
WCLE_003350	COG0574	Belongs to the PEP-utilizing enzyme family
WCLE_003350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WCLE_003380	COG0358	DNA primase activity
WCLE_003390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WCLE_00340	COG4974	Belongs to the 'phage' integrase family
WCLE_003420	COG0564	pseudouridine synthase activity
WCLE_003520	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
WCLE_003520	COG0662	Cupin 2, conserved barrel domain protein
WCLE_003540	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WCLE_003550	COG2009	succinate dehydrogenase
WCLE_003580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WCLE_003630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WCLE_003670	COG0571	ribonuclease III activity
WCLE_003680	COG0167	dihydroorotate dehydrogenase activity
WCLE_00370	COG0372	Belongs to the citrate synthase family
WCLE_003700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WCLE_003750	COG0259	pyridoxamine-phosphate oxidase activity
WCLE_00380	COG0745	RESPONSE REGULATOR receiver
WCLE_003800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WCLE_003820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WCLE_00390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WCLE_003920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WCLE_003920	COG0072	phenylalanine-tRNA ligase activity
WCLE_003950	COG0805	protein transport
WCLE_00400	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WCLE_004040	COG0717	Belongs to the dCTP deaminase family
WCLE_004050	COG1295	ribonuclease BN
WCLE_004060	COG1028	Short-chain dehydrogenase reductase Sdr
WCLE_004070	COG0481	GTPase activity
WCLE_004140	COG2070	2-Nitropropane dioxygenase
WCLE_004170	COG3451	type IV secretory pathway VirB4
WCLE_004220	COG0508	dehydrogenase complex catalyzes the overall conversion of
WCLE_004260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WCLE_004270	COG4536	flavin adenine dinucleotide binding
WCLE_004280	COG3750	Belongs to the UPF0335 family
WCLE_004300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WCLE_004620	COG0328	RNA-DNA hybrid ribonuclease activity
WCLE_004630	COG0109	protoheme IX farnesyltransferase activity
WCLE_004640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WCLE_004650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WCLE_004660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WCLE_004710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WCLE_004720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WCLE_004730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WCLE_004750	COG0484	heat shock protein binding
WCLE_004780	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WCLE_00480	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WCLE_004880	COG1322	Protein conserved in bacteria
WCLE_00490	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WCLE_004990	COG1230	cation diffusion facilitator family transporter
WCLE_005020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WCLE_005030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WCLE_005040	COG1999	signal sequence binding
WCLE_005050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WCLE_005070	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WCLE_005090	COG0045	succinate-CoA ligase (ADP-forming) activity
WCLE_005110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WCLE_005120	COG1268	BioY protein
WCLE_005190	COG2902	Dehydrogenase
WCLE_00520	COG0606	chelatase, subunit chli
WCLE_005200	COG0649	NAD binding
WCLE_005210	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WCLE_005220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WCLE_005240	COG1845	cytochrome c oxidase, subunit III
WCLE_005250	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WCLE_00530	COG0542	response to heat
WCLE_005300	COG0124	histidyl-tRNA synthetase
WCLE_005320	COG0484	heat shock protein binding
WCLE_005330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WCLE_005340	COG0799	negative regulation of ribosome biogenesis
WCLE_005360	COG0494	nUDIX hydrolase
WCLE_005370	COG0084	hydrolase, TatD family'
WCLE_005380	COG0039	L-malate dehydrogenase activity
WCLE_005390	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WCLE_005400	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WCLE_005410	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WCLE_005480	COG3842	ATPase activity
WCLE_005490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WCLE_005500	COG3932	Exopolysaccharide synthesis, ExoD
WCLE_005510	COG0215	cysteine-tRNA ligase activity
WCLE_005530	COG0126	phosphoglycerate kinase activity
WCLE_005540	COG0492	ferredoxin-NADP+ reductase activity
WCLE_005570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WCLE_005580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WCLE_005590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WCLE_005600	COG1104	cysteine desulfurase activity
WCLE_005640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WCLE_005660	COG0439	Biotin carboxylase
WCLE_005700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WCLE_005710	COG0356	it plays a direct role in the translocation of protons across the membrane
WCLE_005750	COG0149	triose-phosphate isomerase activity
WCLE_005790	COG3088	subunit of a heme lyase
WCLE_005820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WCLE_005850	COG0742	ribosomal rna small subunit methyltransferase
WCLE_00590	COG0484	heat shock protein binding
WCLE_005930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WCLE_005950	COG3474	cytochrome
WCLE_005970	COG0114	fumarate hydratase activity
WCLE_005990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WCLE_00600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WCLE_006010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WCLE_006030	COG0573	inorganic phosphate transmembrane transporter activity
WCLE_006040	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WCLE_00610	COG1301	dicarboxylic acid transport
WCLE_006100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WCLE_006100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WCLE_006110	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WCLE_006130	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WCLE_006140	COG1115	amino acid carrier protein
WCLE_006150	COG1183	phosphatidylcholine synthase activity
WCLE_006160	COG0688	phosphatidylethanolamine metabolic process
WCLE_006170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WCLE_006190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WCLE_00620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WCLE_006210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WCLE_006220	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WCLE_006280	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WCLE_006290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WCLE_006330	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
WCLE_006340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WCLE_006420	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WCLE_006430	COG0612	Peptidase, M16
WCLE_006440	COG1132	(ABC) transporter
WCLE_006470	COG0280	phosphate acetyltransferase
WCLE_006470	COG0281	malic enzyme
WCLE_006480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WCLE_006500	COG1674	ftsk spoiiie
WCLE_006530	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WCLE_006540	COG1253	flavin adenine dinucleotide binding
WCLE_006560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WCLE_006570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WCLE_006580	COG0336	Belongs to the RNA methyltransferase TrmD family
WCLE_006590	COG0335	large ribosomal subunit rRNA binding
WCLE_006600	COG0581	inorganic phosphate transmembrane transporter activity
WCLE_006610	COG0047	phosphoribosylformylglycinamidine synthase activity
WCLE_006680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WCLE_00670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WCLE_006710	COG2171	N-acyltransferase activity
WCLE_006750	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WCLE_006780	COG0823	Involved in the tonB-independent uptake of proteins
WCLE_006810	COG0275	rRNA processing
WCLE_00690	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WCLE_006940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WCLE_00700	COG3827	peptidoglycan binding
WCLE_007010	COG0697	spore germination
WCLE_007040	COG1115	amino acid carrier protein
WCLE_007060	COG0459	protein refolding
WCLE_007070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WCLE_007080	COG0354	folic acid binding
WCLE_007130	COG2814	Major facilitator Superfamily
WCLE_007140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WCLE_007150	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WCLE_007190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WCLE_007190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WCLE_00720	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WCLE_007200	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WCLE_007210	COG0316	Belongs to the HesB IscA family
WCLE_007250	COG1104	cysteine desulfurase activity
WCLE_007290	COG4133	protoheme IX ABC transporter activity
WCLE_007380	COG1862	Preprotein translocase
WCLE_007410	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WCLE_007420	COG0237	dephospho-CoA kinase activity
WCLE_007490	COG0681	Belongs to the peptidase S26 family
WCLE_00750	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WCLE_007520	COG0316	Belongs to the HesB IscA family
WCLE_007530	COG0822	iron-sulfur transferase activity
WCLE_007540	COG0552	protein localization to endoplasmic reticulum
WCLE_007550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WCLE_007560	COG0604	alcohol dehydrogenase
WCLE_007560	COG3321	synthase
WCLE_007560	COG1028	Short-chain dehydrogenase reductase Sdr
WCLE_007580	COG0484	heat shock protein binding
WCLE_007600	COG0723	plastoquinol--plastocyanin reductase activity
WCLE_007680	COG1278	Cold shock
WCLE_007690	COG0312	modulator of DNA gyrase
WCLE_007700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WCLE_007840	COG0567	Dehydrogenase, E1 component
WCLE_007920	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WCLE_007950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WCLE_008000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WCLE_00810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WCLE_008120	COG1138	Cytochrome C-type biogenesis protein
WCLE_008150	COG2890	protein-(glutamine-N5) methyltransferase activity
WCLE_008150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WCLE_008180	COG0540	Belongs to the ATCase OTCase family
WCLE_008340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WCLE_00840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WCLE_00850	COG0312	modulator of DNA gyrase
WCLE_008510	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WCLE_008520	COG4106	trans-aconitate 2-methyltransferase activity
WCLE_008550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WCLE_008570	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WCLE_008580	COG2967	ApaG domain
WCLE_008590	COG1178	ABC-type Fe3 transport system permease component
WCLE_008740	COG0009	L-threonylcarbamoyladenylate synthase
WCLE_008790	COG1830	Aldolase
WCLE_00880	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WCLE_008830	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WCLE_008840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WCLE_008860	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WCLE_008880	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WCLE_008890	COG0772	Belongs to the SEDS family
WCLE_00890	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WCLE_008900	COG0651	ATP synthesis coupled electron transport
WCLE_008950	COG0326	Molecular chaperone. Has ATPase activity
WCLE_008970	COG0156	8-amino-7-oxononanoate synthase activity
WCLE_009000	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WCLE_009080	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WCLE_009120	COG0505	Belongs to the CarA family
WCLE_009150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WCLE_009180	COG0250	Participates in transcription elongation, termination and antitermination
WCLE_009190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WCLE_009200	COG0081	regulation of translation
WCLE_009210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WCLE_009230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WCLE_009230	COG0085	RNA polymerase activity
WCLE_009250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WCLE_009260	COG1006	Multisubunit Na H antiporter MnhC subunit
WCLE_009280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WCLE_009280	COG2111	Na H antiporter
WCLE_009310	COG1758	RNA polymerase activity
WCLE_009350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WCLE_00940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WCLE_009430	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WCLE_009440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WCLE_009450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WCLE_009500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WCLE_009540	COG0233	cytoplasmic translational termination
WCLE_009550	COG0528	UMP kinase activity
WCLE_009560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WCLE_009570	COG0052	Belongs to the universal ribosomal protein uS2 family
WCLE_00960	COG0105	UTP biosynthetic process
WCLE_009650	COG0321	lipoyl(octanoyl) transferase activity
WCLE_009660	COG4695	Portal protein
WCLE_009690	COG0592	DNA-directed DNA polymerase activity
WCLE_009700	COG0101	tRNA pseudouridine synthase activity
WCLE_009730	COG0307	riboflavin synthase, alpha
WCLE_009790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WCLE_00980	COG1121	(ABC) transporter
WCLE_009800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WCLE_009870	COG0154	amidase activity
WCLE_009890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WCLE_00990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WCLE_009900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WCLE_009990	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WCLE_010080	COG0138	bifunctional purine biosynthesis protein purh
WCLE_010170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WCLE_010190	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WCLE_010210	COG3451	type IV secretory pathway VirB4
WCLE_010220	COG3704	protein secretion by the type IV secretion system
WCLE_010240	COG1340	protein secretion by the type IV secretion system
WCLE_010240	COG3704	protein secretion by the type IV secretion system
WCLE_010270	COG0024	Methionine aminopeptidase
WCLE_010300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WCLE_010320	COG0543	2 iron, 2 sulfur cluster binding
WCLE_010320	COG0493	'glutamate synthase
WCLE_010330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WCLE_010360	COG0750	zinc metalloprotease
WCLE_010400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WCLE_010500	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WCLE_010530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WCLE_010550	COG1450	Type ii and iii secretion system protein
WCLE_010620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WCLE_010630	COG0629	single-stranded DNA binding
WCLE_010690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WCLE_010700	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WCLE_010740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WCLE_010780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WCLE_010780	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WCLE_010830	COG0525	valine-tRNA ligase activity
WCLE_010850	COG0284	orotidine-5'-phosphate decarboxylase activity
WCLE_010890	COG0508	dehydrogenase complex catalyzes the overall conversion of
WCLE_010920	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WCLE_010930	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WCLE_010960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WCLE_010980	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WCLE_010990	COG0194	GDP metabolic process
WCLE_011040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WCLE_011070	COG1160	GTP binding
WCLE_011130	COG0018	arginyl-trna synthetase
WCLE_011270	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WCLE_011280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WCLE_011360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WCLE_011380	COG1185	polyribonucleotide nucleotidyltransferase activity
WCLE_011390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WCLE_011430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WCLE_011440	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WCLE_011450	COG0740	serine-type endopeptidase activity
WCLE_011460	COG0544	peptidyl-prolyl cis-trans isomerase activity
WCLE_011500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WCLE_011520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WCLE_011530	COG0539	negative regulation of cytoplasmic translation
WCLE_011540	COG0776	regulation of translation
WCLE_011600	COG1840	ABC-type Fe3 transport system, periplasmic component
WCLE_011630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WCLE_011640	COG0254	rRNA binding
WCLE_011650	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WCLE_011670	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WCLE_011720	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
WCLE_011740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WCLE_011740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WCLE_011750	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
WCLE_011790	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WCLE_011800	COG0861	Integral membrane protein TerC family
WCLE_011850	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WCLE_011870	COG0612	Peptidase, M16
WCLE_011880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WCLE_011890	COG0196	riboflavin kinase activity
WCLE_011920	COG2094	Belongs to the DNA glycosylase MPG family
WCLE_011960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WCLE_011980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WCLE_012000	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WCLE_012030	COG0519	Catalyzes the synthesis of GMP from XMP
WCLE_012030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WCLE_012040	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WCLE_012080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WCLE_012090	COG0142	geranyltranstransferase activity
WCLE_012100	COG0228	four-way junction DNA binding
WCLE_012110	COG0736	holo-[acyl-carrier-protein] synthase activity
WCLE_012120	COG0442	prolyl-tRNA aminoacylation
WCLE_012140	COG0768	penicillin binding
WCLE_012210	COG2885	chlorophyll binding
WCLE_012220	COG0037	tRNA processing
WCLE_012230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WCLE_012300	COG0653	protein targeting
WCLE_012340	COG1372	Participates in initiation and elongation during chromosome replication
WCLE_012340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WCLE_012360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WCLE_012370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WCLE_012410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WCLE_012430	COG0587	DNA-directed DNA polymerase activity
WCLE_012440	COG0360	Binds together with S18 to 16S ribosomal RNA
WCLE_012450	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WCLE_012460	COG0359	binds to the 23S rRNA
WCLE_012510	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WCLE_012520	COG1034	ATP synthesis coupled electron transport
WCLE_012560	COG0174	glutamine synthetase