locus-tag	class	description
L2227_00080	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2227_00190	COG1396	sequence-specific DNA binding
L2227_00200	COG2003	Belongs to the UPF0758 family
L2227_00205	COG1396	sequence-specific DNA binding
L2227_00220	COG3344	reverse transcriptase
L2227_00245	COG0484	heat shock protein binding
L2227_00345	COG4804	nuclease activity
L2227_00370	COG2189	Belongs to the N(4) N(6)-methyltransferase family
L2227_00410	COG0101	tRNA pseudouridine synthase activity
L2227_00425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L2227_00450	COG2963	transposase activity
L2227_00455	COG2801	Transposase and inactivated derivatives
L2227_00465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2227_00470	COG0254	rRNA binding
L2227_00475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2227_00480	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2227_00535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L2227_00555	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
L2227_00565	COG3451	type IV secretory pathway VirB4
L2227_00570	COG3704	protein secretion by the type IV secretion system
L2227_00575	COG3704	protein secretion by the type IV secretion system
L2227_00580	COG1340	protein secretion by the type IV secretion system
L2227_00580	COG3704	protein secretion by the type IV secretion system
L2227_00595	COG0742	ribosomal rna small subunit methyltransferase
L2227_00610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L2227_00625	COG3088	subunit of a heme lyase
L2227_00625	COG4235	cytochrome complex assembly
L2227_00640	COG0285	dihydrofolate synthase activity
L2227_00655	COG2867	negative regulation of translational initiation
L2227_00660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2227_00675	COG3547	Transposase (IS116 IS110 IS902 family)
L2227_00690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2227_00700	COG0574	Belongs to the PEP-utilizing enzyme family
L2227_00700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2227_00710	COG1494	fructose-1,6-bisphosphatase
L2227_00725	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2227_00755	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L2227_00760	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2227_00765	COG2226	methyltransferase
L2227_00780	COG3344	reverse transcriptase
L2227_00795	COG1132	(ABC) transporter
L2227_00805	COG0018	arginyl-trna synthetase
L2227_00835	COG4133	protoheme IX ABC transporter activity
L2227_00850	COG0477	Major facilitator Superfamily
L2227_00855	COG0564	pseudouridine synthase activity
L2227_00860	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2227_00865	COG1981	membrane
L2227_00885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L2227_00900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2227_00910	COG0072	phenylalanine-tRNA ligase activity
L2227_00910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2227_00920	COG0356	it plays a direct role in the translocation of protons across the membrane
L2227_00925	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L2227_00950	COG4770	biotin carboxylase activity
L2227_00960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2227_00965	COG1053	succinate dehydrogenase
L2227_00975	COG0194	GDP metabolic process
L2227_01000	COG0012	GTP binding
L2227_01010	COG0617	tRNA 3'-terminal CCA addition
L2227_01035	COG0805	protein transport
L2227_01040	COG1438	arginine binding
L2227_01045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2227_01050	COG0765	amino acid transport
L2227_01055	COG1126	abc transporter atp-binding protein
L2227_01075	COG0284	orotidine-5'-phosphate decarboxylase activity
L2227_01090	COG0525	valine-tRNA ligase activity
L2227_01140	COG1115	amino acid carrier protein
L2227_01175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2227_01205	COG0544	peptidyl-prolyl cis-trans isomerase activity
L2227_01215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L2227_01220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L2227_01230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2227_01240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2227_01255	COG0354	folic acid binding
L2227_01260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L2227_01265	COG0459	protein refolding
L2227_01270	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L2227_01270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L2227_01285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2227_01290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2227_01300	COG2801	Transposase and inactivated derivatives
L2227_01305	COG2963	transposase activity
L2227_01310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2227_01340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2227_01350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L2227_01355	COG0792	nuclease activity
L2227_01365	COG0202	RNA polymerase activity
L2227_01370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L2227_01375	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L2227_01385	COG0201	protein transport
L2227_01395	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L2227_01405	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L2227_01415	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L2227_01450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L2227_01465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L2227_01480	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L2227_01490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L2227_01505	COG0505	Belongs to the CarA family
L2227_01525	COG2814	Major facilitator Superfamily
L2227_01560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2227_01565	COG2239	Acts as a magnesium transporter
L2227_01575	COG2801	Transposase and inactivated derivatives
L2227_01580	COG2801	Transposase and inactivated derivatives
L2227_01590	COG2963	transposase activity
L2227_01610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L2227_01625	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2227_01670	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2227_01670	COG0022	dehydrogenase e1 component
L2227_01675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2227_01685	COG0477	Major facilitator Superfamily
L2227_01705	COG0590	tRNA wobble adenosine to inosine editing
L2227_01710	COG0504	CTP synthase activity
L2227_01735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2227_01740	COG0358	DNA primase activity
L2227_01755	COG2801	Transposase and inactivated derivatives
L2227_01760	COG2801	Transposase and inactivated derivatives
L2227_01770	COG2963	transposase activity
L2227_01780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L2227_01800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2227_01815	COG1074	ATP-dependent DNA helicase activity
L2227_01825	COG2003	Belongs to the UPF0758 family
L2227_01855	COG0697	spore germination
L2227_01865	COG2271	Major facilitator Superfamily
L2227_01880	COG1132	(ABC) transporter
L2227_01900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2227_01905	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L2227_01915	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2227_01930	COG3621	Patatin-like phospholipase
L2227_02130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2227_02175	COG1714	RDD family
L2227_02185	COG0305	Participates in initiation and elongation during chromosome replication
L2227_02195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2227_02230	COG0739	heme binding
L2227_02235	COG0217	transcriptional regulatory protein
L2227_02240	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2227_02250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2227_02255	COG0280	phosphate acetyltransferase
L2227_02255	COG0281	malic enzyme
L2227_02280	COG0114	fumarate hydratase activity
L2227_02290	COG0148	phosphopyruvate hydratase activity
L2227_02300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2227_02325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L2227_02350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L2227_02350	COG2857	Cytochrome c1
L2227_02360	COG0484	heat shock protein binding
L2227_02370	COG0124	histidyl-tRNA synthetase
L2227_02380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2227_02390	COG0493	'glutamate synthase
L2227_02390	COG0543	2 iron, 2 sulfur cluster binding
L2227_02410	COG0750	zinc metalloprotease
L2227_02425	COG0776	regulation of translation
L2227_02430	COG0539	negative regulation of cytoplasmic translation
L2227_02435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2227_02495	COG4804	nuclease activity
L2227_02500	COG1381	Involved in DNA repair and RecF pathway recombination
L2227_02515	COG2902	Dehydrogenase
L2227_02520	COG0542	response to heat
L2227_02535	COG1217	gtp-binding protein TYPA
L2227_02540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L2227_02545	COG1301	dicarboxylic acid transport
L2227_02560	COG1138	Cytochrome C-type biogenesis protein
L2227_02590	COG3577	Aspartyl protease
L2227_02640	COG3344	reverse transcriptase
L2227_02760	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2227_02835	COG1396	sequence-specific DNA binding
L2227_02860	COG0697	spore germination
L2227_02870	COG2271	Major facilitator Superfamily
L2227_02895	COG1132	(ABC) transporter
L2227_02915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2227_02920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L2227_02925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L2227_02940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2227_02955	COG2963	transposase activity
L2227_02960	COG2801	Transposase and inactivated derivatives
L2227_02980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L2227_02990	COG0575	Belongs to the CDS family
L2227_02995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2227_03010	COG0528	UMP kinase activity
L2227_03015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L2227_03020	COG0052	Belongs to the universal ribosomal protein uS2 family
L2227_03030	COG1862	Preprotein translocase
L2227_03065	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2227_03080	COG0653	protein targeting
L2227_03115	COG2963	transposase activity
L2227_03125	COG2801	Transposase and inactivated derivatives
L2227_03130	COG2801	Transposase and inactivated derivatives
L2227_03140	COG0163	prenyltransferase activity
L2227_03145	COG3750	Belongs to the UPF0335 family
L2227_03150	COG4536	flavin adenine dinucleotide binding
L2227_03155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2227_03160	COG0649	NAD binding
L2227_03175	COG1322	Protein conserved in bacteria
L2227_03185	COG0235	Class ii aldolase
L2227_03195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L2227_03220	COG1104	cysteine desulfurase activity
L2227_03225	COG2945	thiolester hydrolase activity
L2227_03240	COG0316	Belongs to the HesB IscA family
L2227_03245	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L2227_03250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2227_03250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2227_03260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2227_03270	COG2171	N-acyltransferase activity
L2227_03305	COG2094	Belongs to the DNA glycosylase MPG family
L2227_03310	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L2227_03315	COG0772	Belongs to the SEDS family
L2227_03320	COG0651	ATP synthesis coupled electron transport
L2227_03345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2227_03350	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
L2227_03360	COG1160	GTP binding
L2227_03410	COG0307	riboflavin synthase, alpha
L2227_03425	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L2227_03435	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L2227_03445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L2227_03455	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2227_03465	COG1845	cytochrome c oxidase, subunit III
L2227_03495	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2227_03505	COG0215	cysteine-tRNA ligase activity
L2227_03515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L2227_03520	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2227_03530	COG0322	excinuclease ABC activity
L2227_03540	COG0752	glycyl-tRNA synthetase alpha subunit
L2227_03550	COG0113	porphobilinogen synthase activity
L2227_03555	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L2227_03560	COG1034	ATP synthesis coupled electron transport
L2227_03575	COG1573	uracil-dna glycosylase
L2227_03580	COG0242	peptide deformylase activity
L2227_03585	COG0849	cell division
L2227_03590	COG0024	Methionine aminopeptidase
L2227_03595	COG0477	Major facilitator Superfamily
L2227_03600	COG0275	rRNA processing
L2227_03630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2227_03640	COG0489	protein tyrosine kinase activity
L2227_03670	COG0632	four-way junction helicase activity
L2227_03715	COG0556	nucleotide-excision repair
L2227_03750	COG0330	HflC and HflK could
L2227_03835	COG4804	nuclease activity
L2227_03890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2227_03990	COG3621	Patatin-like phospholipase
L2227_04050	COG2003	Belongs to the UPF0758 family
L2227_04085	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2227_04105	COG0009	L-threonylcarbamoyladenylate synthase
L2227_04135	COG0736	holo-[acyl-carrier-protein] synthase activity
L2227_04200	COG2003	Belongs to the UPF0758 family
L2227_04210	COG0768	penicillin binding
L2227_04235	COG0567	Dehydrogenase, E1 component
L2227_04245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L2227_04285	COG1006	Multisubunit Na H antiporter MnhC subunit
L2227_04290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L2227_04315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L2227_04325	COG1028	Short-chain dehydrogenase reductase Sdr
L2227_04330	COG1295	ribonuclease BN
L2227_04340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L2227_04345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2227_04350	COG2202	Pas domain
L2227_04350	COG2205	protein histidine kinase activity
L2227_04355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2227_04365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L2227_04375	COG0156	8-amino-7-oxononanoate synthase activity
L2227_04385	COG0326	Molecular chaperone. Has ATPase activity
L2227_04395	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L2227_04410	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
L2227_04425	COG0543	2 iron, 2 sulfur cluster binding
L2227_04425	COG0493	'glutamate synthase
L2227_04430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2227_04440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2227_04465	COG2885	chlorophyll binding
L2227_04475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2227_04485	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L2227_04505	COG3346	SURF1 family
L2227_04530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2227_04550	COG0167	dihydroorotate dehydrogenase activity
L2227_04560	COG1830	Aldolase
L2227_04570	COG0513	Belongs to the DEAD box helicase family
L2227_04575	COG1278	Cold shock
L2227_04580	COG0312	modulator of DNA gyrase
L2227_04585	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L2227_04625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2227_04630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2227_04635	COG0823	Involved in the tonB-independent uptake of proteins
L2227_04680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L2227_04700	COG0776	regulation of translation
L2227_04715	COG0495	leucyl-tRNA aminoacylation
L2227_04730	COG2801	Transposase and inactivated derivatives
L2227_04735	COG2801	Transposase and inactivated derivatives
L2227_04750	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2227_04775	COG3827	peptidoglycan binding
L2227_04780	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
L2227_04825	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L2227_04830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2227_04865	COG0149	triose-phosphate isomerase activity
L2227_04870	COG0758	DNA mediated transformation
L2227_04875	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2227_04895	COG1181	Belongs to the D-alanine--D-alanine ligase family
L2227_04900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2227_04905	COG1686	Belongs to the peptidase S11 family
L2227_04910	COG2076	Multidrug Resistance protein
L2227_04940	COG0372	Belongs to the citrate synthase family
L2227_04955	COG4974	Belongs to the 'phage' integrase family
L2227_04965	COG0628	permease
L2227_04970	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L2227_04970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L2227_04975	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2227_04995	COG3344	reverse transcriptase
L2227_05005	COG1178	ABC-type Fe3 transport system permease component
L2227_05010	COG1054	Belongs to the UPF0176 family
L2227_05025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L2227_05040	COG1090	epimerase
L2227_05065	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2227_05075	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2227_05085	COG0084	hydrolase, TatD family'
L2227_05125	COG1840	ABC-type Fe3 transport system, periplasmic component
L2227_05135	COG0681	Belongs to the peptidase S26 family
L2227_05150	COG0316	Belongs to the HesB IscA family
L2227_05155	COG0822	iron-sulfur transferase activity
L2227_05160	COG0552	protein localization to endoplasmic reticulum
L2227_05165	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L2227_05185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2227_05185	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2227_05195	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
L2227_05240	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L2227_05245	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2227_05280	COG2867	negative regulation of translational initiation
L2227_05295	COG0285	dihydrofolate synthase activity
L2227_05310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L2227_05320	COG1183	phosphatidylcholine synthase activity
L2227_05325	COG1115	amino acid carrier protein
L2227_05330	COG1115	amino acid carrier protein
L2227_05335	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L2227_05345	COG1230	cation diffusion facilitator family transporter
L2227_05360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L2227_05385	COG0436	Aminotransferase
L2227_05395	COG1253	flavin adenine dinucleotide binding
L2227_05410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L2227_05440	COG0047	phosphoribosylformylglycinamidine synthase activity
L2227_05450	COG0321	lipoyl(octanoyl) transferase activity
L2227_05455	COG4695	Portal protein
L2227_05475	COG0445	tRNA wobble uridine modification
L2227_05480	COG0006	proline dipeptidase activity
L2227_05510	COG2801	Transposase and inactivated derivatives
L2227_05515	COG2801	Transposase and inactivated derivatives
L2227_05520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L2227_05520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L2227_05550	COG0312	modulator of DNA gyrase
L2227_05560	COG1104	cysteine desulfurase activity
L2227_05570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L2227_05580	COG1127	ABC transporter
L2227_05585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2227_05590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L2227_05600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L2227_05605	COG0492	ferredoxin-NADP+ reductase activity
L2227_05615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L2227_05620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2227_05635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L2227_05640	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2227_05675	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L2227_05675	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L2227_05675	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L2227_05675	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L2227_05680	COG1007	ATP synthesis coupled electron transport
L2227_05685	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2227_05690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2227_05695	COG0713	ATP synthesis coupled electron transport
L2227_05700	COG0839	Belongs to the complex I subunit 6 family
L2227_05720	COG0527	aspartate kinase activity
L2227_05740	COG0531	amino acid
L2227_05790	COG1396	sequence-specific DNA binding
L2227_05800	COG3344	reverse transcriptase
L2227_05850	COG1674	ftsk spoiiie
L2227_05875	COG0105	UTP biosynthetic process
L2227_05905	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
L2227_05915	COG0142	geranyltranstransferase activity
L2227_05920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2227_05925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2227_05945	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
L2227_05960	COG0723	plastoquinol--plastocyanin reductase activity
L2227_05985	COG1268	BioY protein
L2227_05990	COG0778	Nitroreductase
L2227_06005	COG0045	succinate-CoA ligase (ADP-forming) activity
L2227_06020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2227_06055	COG0187	DNA topoisomerase II activity
L2227_06060	COG1999	signal sequence binding
L2227_06065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2227_06080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2227_06105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2227_06150	COG0626	cystathionine gamma-synthase activity
L2227_06165	COG1530	ribonuclease E activity
L2227_06170	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L2227_06185	COG1121	(ABC) transporter
L2227_06190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2227_06195	COG3547	Transposase (IS116 IS110 IS902 family)
L2227_06235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2227_06245	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L2227_06250	COG0259	pyridoxamine-phosphate oxidase activity
L2227_06260	COG0658	competence protein
L2227_06260	COG2333	competence protein COMEC
L2227_06270	COG0564	pseudouridine synthase activity
L2227_06295	COG2070	2-Nitropropane dioxygenase
L2227_06310	COG3451	type IV secretory pathway VirB4
L2227_06330	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2227_06345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2227_06360	COG1185	polyribonucleotide nucleotidyltransferase activity
L2227_06370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2227_06380	COG3547	Transposase (IS116 IS110 IS902 family)
L2227_06405	COG3547	Transposase (IS116 IS110 IS902 family)
L2227_06425	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
L2227_06430	COG0670	Belongs to the BI1 family
L2227_06435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2227_06465	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L2227_06625	COG2189	Belongs to the N(4) N(6)-methyltransferase family
L2227_06705	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2227_06775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L2227_06820	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L2227_06830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2227_06835	COG0085	RNA polymerase activity
L2227_06835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L2227_06840	COG0222	ribosome binding
L2227_06845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L2227_06850	COG0081	regulation of translation
L2227_06855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L2227_06860	COG0250	Participates in transcription elongation, termination and antitermination
L2227_06875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L2227_06890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L2227_06895	COG2890	protein-(glutamine-N5) methyltransferase activity
L2227_06905	COG3505	Type IV secretory pathway VirD4
L2227_06910	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
L2227_06925	COG3736	Type IV secretory pathway, component VirB8
L2227_06945	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L2227_06955	COG0174	glutamine synthetase
L2227_06965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2227_06975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L2227_06980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L2227_06985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2227_06990	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L2227_07040	COG1475	DNA binding
L2227_07055	COG2009	succinate dehydrogenase
L2227_07060	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2227_07100	COG2801	Transposase and inactivated derivatives
L2227_07105	COG2801	Transposase and inactivated derivatives
L2227_07125	COG2801	Transposase and inactivated derivatives
L2227_07130	COG2801	Transposase and inactivated derivatives
L2227_07145	COG0525	valine-tRNA ligase activity
L2227_07150	COG0237	dephospho-CoA kinase activity
L2227_07155	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
L2227_07165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L2227_07180	COG1253	flavin adenine dinucleotide binding
L2227_07190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2227_07190	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L2227_07230	COG0573	inorganic phosphate transmembrane transporter activity
L2227_07235	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L2227_07240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L2227_07255	COG2814	Major facilitator Superfamily
L2227_07275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L2227_07280	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L2227_07285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L2227_07290	COG0756	dUTP diphosphatase activity
L2227_07325	COG3474	cytochrome
L2227_07345	COG0142	geranyltranstransferase activity
L2227_07365	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L2227_07380	COG0473	3-isopropylmalate dehydrogenase activity
L2227_07385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2227_07390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L2227_07405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2227_07415	COG0359	binds to the 23S rRNA
L2227_07425	COG0360	Binds together with S18 to 16S ribosomal RNA
L2227_07435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2227_07445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2227_07480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L2227_07505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2227_07515	COG0612	Peptidase, M16
L2227_07520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L2227_07525	COG0196	riboflavin kinase activity
L2227_07540	COG0450	alkyl hydroperoxide reductase
L2227_07555	COG4974	Belongs to the 'phage' integrase family
L2227_07560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2227_07600	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2227_07605	COG1294	oxidase, subunit
L2227_07610	COG1271	oxidase subunit
L2227_07615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2227_07620	COG0612	Peptidase, M16
L2227_07630	COG0343	queuine tRNA-ribosyltransferase activity
L2227_07635	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
L2227_07650	COG0745	RESPONSE REGULATOR receiver
L2227_07660	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2227_07675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2227_07705	COG0606	chelatase, subunit chli