locus-tag	class	description
WD_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WD_0004	COG3736	Type IV secretory pathway, component VirB8
WD_0007	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
WD_0010	COG2890	protein-(glutamine-N5) methyltransferase activity
WD_0014	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WD_0015	COG0049	tRNA binding
WD_0016	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WD_0017	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WD_0019	COG0250	Participates in transcription elongation, termination and antitermination
WD_0020	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WD_0021	COG0081	regulation of translation
WD_0022	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WD_0024	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WD_0024	COG0085	RNA polymerase activity
WD_0025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WD_0028	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WD_0036	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WD_0037	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WD_0038	COG0823	Involved in the tonB-independent uptake of proteins
WD_0040	COG0484	heat shock protein binding
WD_0054	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WD_0057	COG0776	regulation of translation
WD_0060	COG0495	leucyl-tRNA aminoacylation
WD_0064	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WD_0067	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WD_0069	COG3827	peptidoglycan binding
WD_0070	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WD_0085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WD_0086	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WD_0090	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WD_0091	COG0149	triose-phosphate isomerase activity
WD_0092	COG0758	DNA mediated transformation
WD_0093	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WD_0095	COG1181	Belongs to the D-alanine--D-alanine ligase family
WD_0096	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WD_0098	COG1686	Belongs to the peptidase S11 family
WD_0100	COG2076	Multidrug Resistance protein
WD_0105	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WD_0106	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WD_0108	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WD_0112	COG0187	DNA topoisomerase II activity
WD_0116	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WD_0120	COG1674	ftsk spoiiie
WD_0130	COG0307	riboflavin synthase, alpha
WD_0132	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WD_0133	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WD_0134	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WD_0135	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WD_0136	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WD_0139	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WD_0141	COG1845	cytochrome c oxidase, subunit III
WD_0142	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WD_0143	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WD_0146	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WD_0149	COG0215	cysteine-tRNA ligase activity
WD_0150	COG3932	Exopolysaccharide synthesis, ExoD
WD_0152	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WD_0153	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WD_0154	COG0322	excinuclease ABC activity
WD_0156	COG0752	glycyl-tRNA synthetase alpha subunit
WD_0158	COG0113	porphobilinogen synthase activity
WD_0159	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WD_0164	COG1573	uracil-dna glycosylase
WD_0165	COG0242	peptide deformylase activity
WD_0166	COG0849	cell division
WD_0167	COG0024	Methionine aminopeptidase
WD_0168	COG0477	Major facilitator Superfamily
WD_0170	COG0275	rRNA processing
WD_0174	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WD_0175	COG0193	aminoacyl-tRNA hydrolase activity
WD_0177	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WD_0185	COG0237	dephospho-CoA kinase activity
WD_0186	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WD_0190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WD_0194	COG1253	flavin adenine dinucleotide binding
WD_0195	COG0519	Catalyzes the synthesis of GMP from XMP
WD_0195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WD_0197	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WD_0197	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WD_0201	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WD_0202	COG0573	inorganic phosphate transmembrane transporter activity
WD_0203	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WD_0204	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WD_0208	COG0235	Class ii aldolase
WD_0217	COG4804	nuclease activity
WD_0219	COG1381	Involved in DNA repair and RecF pathway recombination
WD_0221	COG0745	RESPONSE REGULATOR receiver
WD_0221	COG3706	GGDEF domain
WD_0223	COG2902	Dehydrogenase
WD_0224	COG0542	response to heat
WD_0228	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WD_0229	COG1823	symporter activity
WD_0232	COG1138	Cytochrome C-type biogenesis protein
WD_0236	COG3577	Aspartyl protease
WD_0238	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WD_0243	COG0756	dUTP diphosphatase activity
WD_0245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WD_0246	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WD_0247	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WD_0248	COG2814	Major facilitator Superfamily
WD_0251	COG1322	Protein conserved in bacteria
WD_0253	COG3328	transposase activity
WD_0257	COG2003	Belongs to the UPF0758 family
WD_0263	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WD_0300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WD_0301	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WD_0302	COG0109	protoheme IX farnesyltransferase activity
WD_0304	COG0328	RNA-DNA hybrid ribonuclease activity
WD_0307	COG0459	protein refolding
WD_0308	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WD_0309	COG0354	folic acid binding
WD_0312	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WD_0315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WD_0317	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WD_0318	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WD_0319	COG0740	serine-type endopeptidase activity
WD_0320	COG0544	peptidyl-prolyl cis-trans isomerase activity
WD_0323	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WD_0325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WD_0330	COG1115	amino acid carrier protein
WD_0333	COG0424	maF-like protein
WD_0337	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WD_0340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WD_0341	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WD_0342	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WD_0348	COG0358	DNA primase activity
WD_0350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WD_0352	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WD_0354	COG0305	Participates in initiation and elongation during chromosome replication
WD_0355	COG1714	RDD family
WD_0357	COG2003	Belongs to the UPF0758 family
WD_0359	COG1074	ATP-dependent DNA helicase activity
WD_0360	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WD_0362	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WD_0370	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WD_0375	COG2239	Acts as a magnesium transporter
WD_0379	COG0717	Belongs to the dCTP deaminase family
WD_0384	COG2814	Major facilitator Superfamily
WD_0387	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WD_0388	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WD_0391	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WD_0392	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WD_0393	COG2226	methyltransferase
WD_0400	COG1132	(ABC) transporter
WD_0402	COG0018	arginyl-trna synthetase
WD_0411	COG4133	protoheme IX ABC transporter activity
WD_0413	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WD_0414	COG0477	Major facilitator Superfamily
WD_0415	COG0564	pseudouridine synthase activity
WD_0416	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WD_0421	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WD_0423	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WD_0425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WD_0425	COG0072	phenylalanine-tRNA ligase activity
WD_0427	COG0356	it plays a direct role in the translocation of protons across the membrane
WD_0428	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WD_0432	COG1612	heme a metabolic process
WD_0433	COG0439	Biotin carboxylase
WD_0435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WD_0437	COG1053	succinate dehydrogenase
WD_0439	COG0194	GDP metabolic process
WD_0442	COG0012	GTP binding
WD_0444	COG0617	tRNA 3'-terminal CCA addition
WD_0451	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WD_0452	COG0805	protein transport
WD_0453	COG1438	arginine binding
WD_0455	COG1126	abc transporter atp-binding protein
WD_0461	COG0284	orotidine-5'-phosphate decarboxylase activity
WD_0463	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WD_0464	COG0525	valine-tRNA ligase activity
WD_0468	COG0504	CTP synthase activity
WD_0469	COG0590	tRNA wobble adenosine to inosine editing
WD_0470	COG0477	Major facilitator Superfamily
WD_0472	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WD_0473	COG0508	dehydrogenase complex catalyzes the overall conversion of
WD_0473	COG0022	dehydrogenase e1 component
WD_0477	COG0481	GTPase activity
WD_0483	COG0739	heme binding
WD_0484	COG0217	transcriptional regulatory protein
WD_0485	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WD_0487	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WD_0488	COG0280	phosphate acetyltransferase
WD_0488	COG0281	malic enzyme
WD_0492	COG0114	fumarate hydratase activity
WD_0493	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WD_0494	COG0148	phosphopyruvate hydratase activity
WD_0495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WD_0503	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WD_0505	COG0154	amidase activity
WD_0509	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WD_0524	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WD_0526	COG0575	Belongs to the CDS family
WD_0527	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WD_0529	COG0233	cytoplasmic translational termination
WD_0530	COG0528	UMP kinase activity
WD_0531	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WD_0532	COG0052	Belongs to the universal ribosomal protein uS2 family
WD_0534	COG1862	Preprotein translocase
WD_0541	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WD_0544	COG0508	dehydrogenase complex catalyzes the overall conversion of
WD_0549	COG0653	protein targeting
WD_0551	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WD_0555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WD_0556	COG0163	prenyltransferase activity
WD_0557	COG3750	Belongs to the UPF0335 family
WD_0558	COG4536	flavin adenine dinucleotide binding
WD_0559	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WD_0560	COG0649	NAD binding
WD_0594	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WD_0596	COG0666	response to abiotic stimulus
WD_0610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WD_0611	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WD_0612	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WD_0616	COG1132	(ABC) transporter
WD_0621	COG0697	spore germination
WD_0625	COG2003	Belongs to the UPF0758 family
WD_0626	COG1396	sequence-specific DNA binding
WD_0637	COG0666	response to abiotic stimulus
WD_0649	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WD_0654	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WD_0655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WD_0656	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WD_0657	COG0203	ribosomal protein L17
WD_0658	COG0202	RNA polymerase activity
WD_0659	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WD_0660	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WD_0661	COG0563	adenylate kinase activity
WD_0662	COG0201	protein transport
WD_0663	COG0200	Binds to the 23S rRNA
WD_0664	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WD_0665	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WD_0666	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WD_0667	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WD_0668	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WD_0669	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WD_0670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WD_0671	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WD_0672	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WD_0673	COG0255	Belongs to the universal ribosomal protein uL29 family
WD_0674	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WD_0675	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WD_0676	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WD_0677	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WD_0678	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WD_0680	COG0088	Forms part of the polypeptide exit tunnel
WD_0681	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WD_0682	COG0051	transcription antitermination factor activity, RNA binding
WD_0683	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WD_0684	COG0505	Belongs to the CarA family
WD_0687	COG1494	fructose-1,6-bisphosphatase
WD_0690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WD_0690	COG0574	Belongs to the PEP-utilizing enzyme family
WD_0693	COG3344	reverse transcriptase
WD_0695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WD_0699	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WD_0705	COG1104	cysteine desulfurase activity
WD_0706	COG2945	thiolester hydrolase activity
WD_0708	COG0316	Belongs to the HesB IscA family
WD_0709	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WD_0710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WD_0710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WD_0712	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WD_0714	COG2171	N-acyltransferase activity
WD_0719	COG0768	penicillin binding
WD_0721	COG0606	chelatase, subunit chli
WD_0726	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WD_0727	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WD_0730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WD_0731	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WD_0732	COG0745	RESPONSE REGULATOR receiver
WD_0734	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WD_0735	COG0343	queuine tRNA-ribosyltransferase activity
WD_0737	COG0612	Peptidase, M16
WD_0738	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WD_0740	COG1271	oxidase subunit
WD_0741	COG1294	oxidase, subunit
WD_0743	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WD_0751	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WD_0752	COG4974	Belongs to the 'phage' integrase family
WD_0756	COG0450	alkyl hydroperoxide reductase
WD_0759	COG0196	riboflavin kinase activity
WD_0760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WD_0761	COG0612	Peptidase, M16
WD_0763	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WD_0767	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WD_0768	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WD_0774	COG0629	single-stranded DNA binding
WD_0775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WD_0776	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WD_0778	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WD_0780	COG0587	DNA-directed DNA polymerase activity
WD_0781	COG0360	Binds together with S18 to 16S ribosomal RNA
WD_0782	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WD_0783	COG0359	binds to the 23S rRNA
WD_0786	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WD_0788	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WD_0789	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WD_0791	COG0473	3-isopropylmalate dehydrogenase activity
WD_0795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WD_0798	COG0228	four-way junction DNA binding
WD_0799	COG0142	geranyltranstransferase activity
WD_0800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WD_0803	COG3474	cytochrome
WD_0813	COG0442	prolyl-tRNA aminoacylation
WD_0814	COG0736	holo-[acyl-carrier-protein] synthase activity
WD_0820	COG0009	L-threonylcarbamoyladenylate synthase
WD_0822	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WD_0824	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WD_0832	COG0330	HflC and HflK could
WD_0839	COG0556	nucleotide-excision repair
WD_0844	COG3088	subunit of a heme lyase
WD_0844	COG4235	cytochrome complex assembly
WD_0849	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WD_0852	COG0742	ribosomal rna small subunit methyltransferase
WD_0855	COG3704	protein secretion by the type IV secretion system
WD_0855	COG1340	protein secretion by the type IV secretion system
WD_0856	COG3704	protein secretion by the type IV secretion system
WD_0857	COG3704	protein secretion by the type IV secretion system
WD_0858	COG3451	type IV secretory pathway VirB4
WD_0860	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WD_0862	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WD_0864	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WD_0865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WD_0866	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WD_0868	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WD_0869	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WD_0870	COG0254	rRNA binding
WD_0871	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WD_0880	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
WD_0883	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WD_0883	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WD_0887	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WD_0888	COG0552	protein localization to endoplasmic reticulum
WD_0889	COG0822	iron-sulfur transferase activity
WD_0890	COG0316	Belongs to the HesB IscA family
WD_0891	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WD_0893	COG0681	Belongs to the peptidase S26 family
WD_0895	COG0540	Belongs to the ATCase OTCase family
WD_0897	COG1840	ABC-type Fe3 transport system, periplasmic component
WD_0904	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WD_0905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WD_0906	COG1185	polyribonucleotide nucleotidyltransferase activity
WD_0913	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WD_0925	COG0626	cystathionine gamma-synthase activity
WD_0928	COG0443	Heat shock 70 kDa protein
WD_0929	COG1530	ribonuclease E activity
WD_0930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WD_0938	COG1121	(ABC) transporter
WD_0939	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WD_0949	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WD_0950	COG0670	Belongs to the BI1 family
WD_0951	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WD_0954	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WD_0957	COG0531	amino acid
WD_0960	COG0527	aspartate kinase activity
WD_0965	COG0839	Belongs to the complex I subunit 6 family
WD_0966	COG0713	ATP synthesis coupled electron transport
WD_0967	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WD_0968	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WD_0969	COG1007	ATP synthesis coupled electron transport
WD_0970	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WD_0970	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WD_0970	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WD_0970	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WD_0972	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WD_0976	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WD_0977	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WD_0978	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WD_0980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WD_0981	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WD_0982	COG0492	ferredoxin-NADP+ reductase activity
WD_0985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WD_0986	COG0416	fatty acid biosynthetic process
WD_0987	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WD_0989	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WD_0990	COG1127	ABC transporter
WD_0992	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WD_0995	COG3344	reverse transcriptase
WD_0997	COG1104	cysteine desulfurase activity
WD_0998	COG0312	modulator of DNA gyrase
WD_1003	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WD_1003	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WD_1009	COG0445	tRNA wobble uridine modification
WD_1012	COG4695	Portal protein
WD_1014	COG0321	lipoyl(octanoyl) transferase activity
WD_1015	COG1619	proteins homologs of microcin C7 resistance protein MccF
WD_1018	COG0047	phosphoribosylformylglycinamidine synthase activity
WD_1021	COG0335	large ribosomal subunit rRNA binding
WD_1022	COG0336	Belongs to the RNA methyltransferase TrmD family
WD_1023	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WD_1024	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WD_1027	COG1253	flavin adenine dinucleotide binding
WD_1028	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WD_1035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WD_1042	COG1230	cation diffusion facilitator family transporter
WD_1045	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WD_1046	COG1115	amino acid carrier protein
WD_1047	COG1115	amino acid carrier protein
WD_1048	COG1183	phosphatidylcholine synthase activity
WD_1049	COG0688	phosphatidylethanolamine metabolic process
WD_1050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WD_1051	COG0484	heat shock protein binding
WD_1052	COG0285	dihydrofolate synthase activity
WD_1054	COG2867	negative regulation of translational initiation
WD_1060	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WD_1061	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WD_1064	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WD_1067	COG0592	DNA-directed DNA polymerase activity
WD_1068	COG0101	tRNA pseudouridine synthase activity
WD_1070	COG2857	Cytochrome c1
WD_1070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WD_1071	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WD_1074	COG0484	heat shock protein binding
WD_1076	COG0124	histidyl-tRNA synthetase
WD_1077	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WD_1080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WD_1082	COG0543	2 iron, 2 sulfur cluster binding
WD_1082	COG0493	'glutamate synthase
WD_1083	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WD_1086	COG0750	zinc metalloprotease
WD_1089	COG0776	regulation of translation
WD_1090	COG0539	negative regulation of cytoplasmic translation
WD_1091	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WD_1094	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WD_1098	COG1160	GTP binding
WD_1102	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WD_1103	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WD_1107	COG0651	ATP synthesis coupled electron transport
WD_1108	COG0772	Belongs to the SEDS family
WD_1109	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WD_1110	COG2094	Belongs to the DNA glycosylase MPG family
WD_1112	COG2255	four-way junction helicase activity
WD_1113	COG0632	four-way junction helicase activity
WD_1115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WD_1119	COG0494	nUDIX hydrolase
WD_1120	COG0084	hydrolase, TatD family'
WD_1121	COG0039	L-malate dehydrogenase activity
WD_1122	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WD_1123	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WD_1124	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WD_1129	COG1090	epimerase
WD_1133	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WD_1136	COG1178	ABC-type Fe3 transport system permease component
WD_1138	COG3344	reverse transcriptase
WD_1141	COG2967	ApaG domain
WD_1142	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WD_1143	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WD_1143	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WD_1144	COG0628	permease
WD_1148	COG4974	Belongs to the 'phage' integrase family
WD_1150	COG0268	Binds directly to 16S ribosomal RNA
WD_1151	COG0372	Belongs to the citrate synthase family
WD_1157	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WD_1158	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WD_1159	COG0259	pyridoxamine-phosphate oxidase activity
WD_1160	COG2333	competence protein COMEC
WD_1160	COG0658	competence protein
WD_1162	COG0564	pseudouridine synthase activity
WD_1167	COG0126	phosphoglycerate kinase activity
WD_1170	COG2070	2-Nitropropane dioxygenase
WD_1173	COG3451	type IV secretory pathway VirB4
WD_1177	COG0508	dehydrogenase complex catalyzes the overall conversion of
WD_1180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WD_1183	COG0105	UTP biosynthetic process
WD_1186	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WD_1189	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WD_1190	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WD_1192	COG0142	geranyltranstransferase activity
WD_1193	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WD_1194	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WD_1197	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WD_1198	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
WD_1201	COG0723	plastoquinol--plastocyanin reductase activity
WD_1206	COG1268	BioY protein
WD_1207	COG0778	Nitroreductase
WD_1209	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WD_1210	COG0045	succinate-CoA ligase (ADP-forming) activity
WD_1212	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WD_1217	COG1192	Involved in chromosome partitioning
WD_1218	COG1475	DNA binding
WD_1221	COG2009	succinate dehydrogenase
WD_1222	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WD_1229	COG4591	ABC-type transport system involved in lipoprotein release permease component
WD_1233	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WD_1234	COG0312	modulator of DNA gyrase
WD_1235	COG1278	Cold shock
WD_1236	COG0513	Belongs to the DEAD box helicase family
WD_1238	COG1830	Aldolase
WD_1239	COG0167	dihydroorotate dehydrogenase activity
WD_1240	COG0571	ribonuclease III activity
WD_1251	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WD_1253	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WD_1254	COG0037	tRNA processing
WD_1255	COG2885	chlorophyll binding
WD_1259	COG0482	sulfurtransferase activity
WD_1263	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WD_1266	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WD_1267	COG0543	2 iron, 2 sulfur cluster binding
WD_1267	COG0493	'glutamate synthase
WD_1271	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WD_1274	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WD_1277	COG0326	Molecular chaperone. Has ATPase activity
WD_1279	COG0156	8-amino-7-oxononanoate synthase activity
WD_1281	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WD_1282	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WD_1283	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WD_1284	COG2202	Pas domain
WD_1284	COG2205	protein histidine kinase activity
WD_1285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WD_1286	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WD_1292	COG1295	ribonuclease BN
WD_1293	COG1028	Short-chain dehydrogenase reductase Sdr
WD_1295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WD_1298	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WD_1299	COG1006	Multisubunit Na H antiporter MnhC subunit
WD_1303	COG1758	RNA polymerase activity
WD_1305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WD_1309	COG0567	Dehydrogenase, E1 component
WD_1315	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WD_1316	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WD_1317	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WD_1318	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WD_1320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WD_1322	COG0174	glutamine synthetase