locus-tag	class	description
wSan_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
wSan_00040	COG3736	Type IV secretory pathway, component VirB8
wSan_00070	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
wSan_00080	COG3505	Type IV secretory pathway VirD4
wSan_00100	COG2890	protein-(glutamine-N5) methyltransferase activity
wSan_00110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
wSan_00140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
wSan_00160	COG0250	Participates in transcription elongation, termination and antitermination
wSan_00170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
wSan_00180	COG0081	regulation of translation
wSan_00190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
wSan_00200	COG0222	ribosome binding
wSan_00210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
wSan_00210	COG0085	RNA polymerase activity
wSan_00220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
wSan_00240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
wSan_00300	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
wSan_00310	COG3827	peptidoglycan binding
wSan_00360	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
wSan_00390	COG0495	leucyl-tRNA aminoacylation
wSan_00420	COG0776	regulation of translation
wSan_00440	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
wSan_00530	COG0823	Involved in the tonB-independent uptake of proteins
wSan_00540	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
wSan_00550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
wSan_00620	COG0154	amidase activity
wSan_00720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
wSan_00730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
wSan_00760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
wSan_00770	COG0149	triose-phosphate isomerase activity
wSan_00780	COG0758	DNA mediated transformation
wSan_00790	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
wSan_00820	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
wSan_00830	COG1686	Belongs to the peptidase S11 family
wSan_00880	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
wSan_00910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
wSan_00930	COG0187	DNA topoisomerase II activity
wSan_00960	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
wSan_00990	COG1674	ftsk spoiiie
wSan_01090	COG0307	riboflavin synthase, alpha
wSan_01110	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
wSan_01120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
wSan_01130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
wSan_01140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
wSan_01150	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
wSan_01200	COG1845	cytochrome c oxidase, subunit III
wSan_01220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
wSan_01230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
wSan_01260	COG0215	cysteine-tRNA ligase activity
wSan_01270	COG3932	Exopolysaccharide synthesis, ExoD
wSan_01290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
wSan_01300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
wSan_01310	COG0322	excinuclease ABC activity
wSan_01330	COG0752	glycyl-tRNA synthetase alpha subunit
wSan_01350	COG0113	porphobilinogen synthase activity
wSan_01360	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
wSan_01390	COG1573	uracil-dna glycosylase
wSan_01400	COG0242	peptide deformylase activity
wSan_01410	COG0849	cell division
wSan_01420	COG0024	Methionine aminopeptidase
wSan_01430	COG0477	Major facilitator Superfamily
wSan_01440	COG0275	rRNA processing
wSan_01480	COG0193	aminoacyl-tRNA hydrolase activity
wSan_01500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
wSan_01520	COG0489	protein tyrosine kinase activity
wSan_01570	COG0237	dephospho-CoA kinase activity
wSan_01580	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
wSan_01590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
wSan_01620	COG1253	flavin adenine dinucleotide binding
wSan_01640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
wSan_01640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
wSan_01690	COG0573	inorganic phosphate transmembrane transporter activity
wSan_01700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
wSan_01710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
wSan_01750	COG2814	Major facilitator Superfamily
wSan_01760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
wSan_01770	COG0218	Necessary for normal cell division and for the maintenance of normal septation
wSan_01780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
wSan_01790	COG0756	dUTP diphosphatase activity
wSan_01850	COG3577	Aspartyl protease
wSan_01880	COG1138	Cytochrome C-type biogenesis protein
wSan_01910	COG1301	dicarboxylic acid transport
wSan_01920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
wSan_01930	COG1217	gtp-binding protein TYPA
wSan_01960	COG0542	response to heat
wSan_01970	COG2902	Dehydrogenase
wSan_02000	COG1381	Involved in DNA repair and RecF pathway recombination
wSan_02020	COG4804	nuclease activity
wSan_02090	COG0235	Class ii aldolase
wSan_02110	COG1322	Protein conserved in bacteria
wSan_02240	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
wSan_02250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
wSan_02260	COG0109	protoheme IX farnesyltransferase activity
wSan_02270	COG0328	RNA-DNA hybrid ribonuclease activity
wSan_02290	COG0459	protein refolding
wSan_02300	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
wSan_02310	COG0354	folic acid binding
wSan_02320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
wSan_02330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
wSan_02350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
wSan_02360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
wSan_02370	COG0740	serine-type endopeptidase activity
wSan_02380	COG0544	peptidyl-prolyl cis-trans isomerase activity
wSan_02430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
wSan_02520	COG1115	amino acid carrier protein
wSan_02540	COG0424	maF-like protein
wSan_02580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
wSan_02610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
wSan_02680	COG0358	DNA primase activity
wSan_02690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
wSan_02710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
wSan_02730	COG0305	Participates in initiation and elongation during chromosome replication
wSan_02740	COG1714	RDD family
wSan_02750	COG2003	Belongs to the UPF0758 family
wSan_02770	COG1074	ATP-dependent DNA helicase activity
wSan_02780	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
wSan_02800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
wSan_02840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
wSan_02870	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
wSan_02880	COG2239	Acts as a magnesium transporter
wSan_02960	COG2814	Major facilitator Superfamily
wSan_02980	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
wSan_03020	COG0227	Belongs to the bacterial ribosomal protein bL28 family
wSan_03030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
wSan_03040	COG2226	methyltransferase
wSan_03070	COG3344	reverse transcriptase
wSan_03080	COG1132	(ABC) transporter
wSan_03100	COG0018	arginyl-trna synthetase
wSan_03140	COG4133	protoheme IX ABC transporter activity
wSan_03170	COG0477	Major facilitator Superfamily
wSan_03180	COG0564	pseudouridine synthase activity
wSan_03190	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
wSan_03200	COG1981	membrane
wSan_03210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
wSan_03230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
wSan_03250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
wSan_03250	COG0072	phenylalanine-tRNA ligase activity
wSan_03270	COG0356	it plays a direct role in the translocation of protons across the membrane
wSan_03280	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
wSan_03320	COG1612	heme a metabolic process
wSan_03330	COG4770	biotin carboxylase activity
wSan_03350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
wSan_03360	COG1053	succinate dehydrogenase
wSan_03380	COG0194	GDP metabolic process
wSan_03410	COG0012	GTP binding
wSan_03430	COG0617	tRNA 3'-terminal CCA addition
wSan_03460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
wSan_03470	COG0805	protein transport
wSan_03480	COG1438	arginine binding
wSan_03490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
wSan_03500	COG0765	amino acid transport
wSan_03510	COG1126	abc transporter atp-binding protein
wSan_03540	COG0284	orotidine-5'-phosphate decarboxylase activity
wSan_03570	COG0525	valine-tRNA ligase activity
wSan_03610	COG0504	CTP synthase activity
wSan_03620	COG0590	tRNA wobble adenosine to inosine editing
wSan_03630	COG0477	Major facilitator Superfamily
wSan_03650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
wSan_03660	COG0508	dehydrogenase complex catalyzes the overall conversion of
wSan_03660	COG0022	dehydrogenase e1 component
wSan_03680	COG0481	GTPase activity
wSan_03730	COG0739	heme binding
wSan_03740	COG0217	transcriptional regulatory protein
wSan_03750	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
wSan_03770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
wSan_03780	COG0280	phosphate acetyltransferase
wSan_03780	COG0281	malic enzyme
wSan_03820	COG0114	fumarate hydratase activity
wSan_03830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
wSan_03840	COG0148	phosphopyruvate hydratase activity
wSan_03850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
wSan_03900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
wSan_03960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
wSan_04010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
wSan_04020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
wSan_04030	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
wSan_04040	COG0792	nuclease activity
wSan_04060	COG0202	RNA polymerase activity
wSan_04070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
wSan_04080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
wSan_04090	COG0563	adenylate kinase activity
wSan_04100	COG0201	protein transport
wSan_04120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
wSan_04140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
wSan_04160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
wSan_04210	COG0255	Belongs to the universal ribosomal protein uL29 family
wSan_04230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
wSan_04260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
wSan_04270	COG0089	rRNA binding
wSan_04290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
wSan_04310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
wSan_04320	COG0505	Belongs to the CarA family
wSan_04350	COG1494	fructose-1,6-bisphosphatase
wSan_04370	COG0574	Belongs to the PEP-utilizing enzyme family
wSan_04370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
wSan_04430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
wSan_04460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
wSan_04480	COG1104	cysteine desulfurase activity
wSan_04490	COG2945	thiolester hydrolase activity
wSan_04520	COG0316	Belongs to the HesB IscA family
wSan_04530	COG0232	Belongs to the dGTPase family. Type 2 subfamily
wSan_04540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
wSan_04540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
wSan_04560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
wSan_04580	COG2171	N-acyltransferase activity
wSan_04630	COG0768	penicillin binding
wSan_04650	COG0606	chelatase, subunit chli
wSan_04710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
wSan_04740	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
wSan_04750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
wSan_04760	COG0745	RESPONSE REGULATOR receiver
wSan_04780	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
wSan_04790	COG0343	queuine tRNA-ribosyltransferase activity
wSan_04810	COG0612	Peptidase, M16
wSan_04820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
wSan_04830	COG1271	oxidase subunit
wSan_04840	COG1294	oxidase, subunit
wSan_04860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
wSan_04920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
wSan_04930	COG4974	Belongs to the 'phage' integrase family
wSan_04960	COG0450	alkyl hydroperoxide reductase
wSan_04990	COG0196	riboflavin kinase activity
wSan_05000	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
wSan_05010	COG0612	Peptidase, M16
wSan_05030	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
wSan_05100	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
wSan_05150	COG0629	single-stranded DNA binding
wSan_05160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
wSan_05170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
wSan_05180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
wSan_05200	COG0360	Binds together with S18 to 16S ribosomal RNA
wSan_05220	COG0359	binds to the 23S rRNA
wSan_05230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
wSan_05250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
wSan_05260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
wSan_05280	COG0473	3-isopropylmalate dehydrogenase activity
wSan_05310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
wSan_05350	COG0142	geranyltranstransferase activity
wSan_05360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
wSan_05390	COG3474	cytochrome
wSan_05440	COG0442	prolyl-tRNA aminoacylation
wSan_05450	COG0736	holo-[acyl-carrier-protein] synthase activity
wSan_05520	COG0009	L-threonylcarbamoyladenylate synthase
wSan_05540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
wSan_05560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
wSan_05630	COG0330	HflC and HflK could
wSan_05680	COG0556	nucleotide-excision repair
wSan_05710	COG3088	subunit of a heme lyase
wSan_05710	COG4235	cytochrome complex assembly
wSan_05740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
wSan_05770	COG0742	ribosomal rna small subunit methyltransferase
wSan_05800	COG3704	protein secretion by the type IV secretion system
wSan_05800	COG1340	protein secretion by the type IV secretion system
wSan_05810	COG3704	protein secretion by the type IV secretion system
wSan_05820	COG3704	protein secretion by the type IV secretion system
wSan_05830	COG3451	type IV secretory pathway VirB4
wSan_05850	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
wSan_05860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
wSan_05900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
wSan_05920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
wSan_05930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
wSan_05940	COG0254	rRNA binding
wSan_05950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
wSan_06020	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
wSan_06040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
wSan_06040	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
wSan_06070	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
wSan_06080	COG0552	protein localization to endoplasmic reticulum
wSan_06090	COG0822	iron-sulfur transferase activity
wSan_06100	COG0316	Belongs to the HesB IscA family
wSan_06110	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
wSan_06130	COG0681	Belongs to the peptidase S26 family
wSan_06150	COG1840	ABC-type Fe3 transport system, periplasmic component
wSan_06200	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
wSan_06210	COG0670	Belongs to the BI1 family
wSan_06220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
wSan_06240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
wSan_06270	COG0531	amino acid
wSan_06290	COG0527	aspartate kinase activity
wSan_06340	COG0839	Belongs to the complex I subunit 6 family
wSan_06350	COG0713	ATP synthesis coupled electron transport
wSan_06360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
wSan_06370	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
wSan_06380	COG1007	ATP synthesis coupled electron transport
wSan_06390	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
wSan_06390	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
wSan_06390	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
wSan_06390	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
wSan_06410	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
wSan_06500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
wSan_06570	COG1185	polyribonucleotide nucleotidyltransferase activity
wSan_06590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
wSan_06650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
wSan_06660	COG1121	(ABC) transporter
wSan_06700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
wSan_06710	COG1530	ribonuclease E activity
wSan_06720	COG0443	Heat shock 70 kDa protein
wSan_06740	COG0626	cystathionine gamma-synthase activity
wSan_06820	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
wSan_06830	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
wSan_06840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
wSan_06860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
wSan_06870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
wSan_06880	COG0492	ferredoxin-NADP+ reductase activity
wSan_06890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
wSan_06910	COG0333	Belongs to the bacterial ribosomal protein bL32 family
wSan_06920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
wSan_06930	COG1127	ABC transporter
wSan_06950	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
wSan_06980	COG1104	cysteine desulfurase activity
wSan_06990	COG0312	modulator of DNA gyrase
wSan_07040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
wSan_07040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
wSan_07100	COG0445	tRNA wobble uridine modification
wSan_07130	COG4695	Portal protein
wSan_07150	COG0321	lipoyl(octanoyl) transferase activity
wSan_07180	COG0047	phosphoribosylformylglycinamidine synthase activity
wSan_07220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
wSan_07230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
wSan_07260	COG1253	flavin adenine dinucleotide binding
wSan_07270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
wSan_07280	COG0436	Aminotransferase
wSan_07330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
wSan_07380	COG1230	cation diffusion facilitator family transporter
wSan_07400	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
wSan_07410	COG1115	amino acid carrier protein
wSan_07420	COG1115	amino acid carrier protein
wSan_07430	COG1183	phosphatidylcholine synthase activity
wSan_07450	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
wSan_07460	COG0484	heat shock protein binding
wSan_07470	COG0285	dihydrofolate synthase activity
wSan_07490	COG2867	negative regulation of translational initiation
wSan_07550	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
wSan_07560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
wSan_07580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
wSan_07610	COG0101	tRNA pseudouridine synthase activity
wSan_07630	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
wSan_07630	COG2857	Cytochrome c1
wSan_07640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
wSan_07670	COG0484	heat shock protein binding
wSan_07690	COG0124	histidyl-tRNA synthetase
wSan_07710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
wSan_07730	COG0543	2 iron, 2 sulfur cluster binding
wSan_07730	COG0493	'glutamate synthase
wSan_07740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
wSan_07770	COG0750	zinc metalloprotease
wSan_07800	COG0776	regulation of translation
wSan_07810	COG0539	negative regulation of cytoplasmic translation
wSan_07820	COG0220	tRNA (guanine-N7-)-methyltransferase activity
wSan_07870	COG1160	GTP binding
wSan_07890	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
wSan_07900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
wSan_07910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
wSan_07950	COG0651	ATP synthesis coupled electron transport
wSan_07960	COG0772	Belongs to the SEDS family
wSan_07970	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
wSan_07980	COG2094	Belongs to the DNA glycosylase MPG family
wSan_08000	COG2255	four-way junction helicase activity
wSan_08010	COG0632	four-way junction helicase activity
wSan_08060	COG0494	nUDIX hydrolase
wSan_08070	COG0084	hydrolase, TatD family'
wSan_08090	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
wSan_08110	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
wSan_08160	COG1090	epimerase
wSan_08180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
wSan_08190	COG1054	Belongs to the UPF0176 family
wSan_08200	COG1178	ABC-type Fe3 transport system permease component
wSan_08240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
wSan_08250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
wSan_08250	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
wSan_08260	COG0628	permease
wSan_08290	COG4974	Belongs to the 'phage' integrase family
wSan_08310	COG0268	Binds directly to 16S ribosomal RNA
wSan_08320	COG0372	Belongs to the citrate synthase family
wSan_08350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
wSan_08360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
wSan_08370	COG0259	pyridoxamine-phosphate oxidase activity
wSan_08380	COG2333	competence protein COMEC
wSan_08380	COG0658	competence protein
wSan_08400	COG0564	pseudouridine synthase activity
wSan_08430	COG0126	phosphoglycerate kinase activity
wSan_08450	COG2070	2-Nitropropane dioxygenase
wSan_08480	COG3451	type IV secretory pathway VirB4
wSan_08530	COG0723	plastoquinol--plastocyanin reductase activity
wSan_08560	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
wSan_08570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
wSan_08590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
wSan_08600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
wSan_08610	COG0142	geranyltranstransferase activity
wSan_08630	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
wSan_08670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
wSan_08690	COG0105	UTP biosynthetic process
wSan_08700	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
wSan_08730	COG0508	dehydrogenase complex catalyzes the overall conversion of
wSan_08780	COG1268	BioY protein
wSan_08790	COG0778	Nitroreductase
wSan_08810	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
wSan_08820	COG0045	succinate-CoA ligase (ADP-forming) activity
wSan_08840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
wSan_08900	COG1475	DNA binding
wSan_08920	COG0653	protein targeting
wSan_09150	COG4804	nuclease activity
wSan_09200	COG2189	Belongs to the N(4) N(6)-methyltransferase family
wSan_09670	COG2189	Belongs to the N(4) N(6)-methyltransferase family
wSan_09690	COG0666	response to abiotic stimulus
wSan_09730	COG4804	nuclease activity
wSan_10030	COG1396	sequence-specific DNA binding
wSan_10040	COG2003	Belongs to the UPF0758 family
wSan_10080	COG0697	spore germination
wSan_10130	COG1132	(ABC) transporter
wSan_10170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
wSan_10180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
wSan_10350	COG2189	Belongs to the N(4) N(6)-methyltransferase family
wSan_10660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
wSan_10670	COG3621	Patatin-like phospholipase
wSan_10710	COG2003	Belongs to the UPF0758 family
wSan_10810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
wSan_10830	COG0575	Belongs to the CDS family
wSan_10840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
wSan_10860	COG0233	cytoplasmic translational termination
wSan_10870	COG0528	UMP kinase activity
wSan_10880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
wSan_10890	COG0052	Belongs to the universal ribosomal protein uS2 family
wSan_10900	COG1862	Preprotein translocase
wSan_11070	COG3344	reverse transcriptase
wSan_11080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
wSan_11100	COG0508	dehydrogenase complex catalyzes the overall conversion of
wSan_11120	COG0653	protein targeting
wSan_11170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
wSan_11180	COG0163	prenyltransferase activity
wSan_11190	COG3750	Belongs to the UPF0335 family
wSan_11200	COG4536	flavin adenine dinucleotide binding
wSan_11210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
wSan_11220	COG0649	NAD binding
wSan_11260	COG3621	Patatin-like phospholipase
wSan_11550	COG2009	succinate dehydrogenase
wSan_11560	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
wSan_11620	COG4591	ABC-type transport system involved in lipoprotein release permease component
wSan_11650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
wSan_11660	COG0312	modulator of DNA gyrase
wSan_11670	COG1278	Cold shock
wSan_11680	COG0513	Belongs to the DEAD box helicase family
wSan_11700	COG1830	Aldolase
wSan_11710	COG0167	dihydroorotate dehydrogenase activity
wSan_11740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
wSan_11820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
wSan_11840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
wSan_11850	COG0037	tRNA processing
wSan_11860	COG2885	chlorophyll binding
wSan_11890	COG0482	sulfurtransferase activity
wSan_11910	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
wSan_11920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
wSan_11930	COG0543	2 iron, 2 sulfur cluster binding
wSan_11930	COG0493	'glutamate synthase
wSan_11960	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
wSan_11990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
wSan_12000	COG0326	Molecular chaperone. Has ATPase activity
wSan_12020	COG0156	8-amino-7-oxononanoate synthase activity
wSan_12040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
wSan_12060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
wSan_12070	COG2202	Pas domain
wSan_12070	COG2205	protein histidine kinase activity
wSan_12080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
wSan_12090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
wSan_12130	COG1295	ribonuclease BN
wSan_12140	COG1028	Short-chain dehydrogenase reductase Sdr
wSan_12150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
wSan_12180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
wSan_12190	COG1006	Multisubunit Na H antiporter MnhC subunit
wSan_12210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
wSan_12210	COG2111	Na H antiporter
wSan_12260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
wSan_12280	COG0567	Dehydrogenase, E1 component
wSan_12330	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
wSan_12340	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
wSan_12350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
wSan_12360	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
wSan_12380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
wSan_12400	COG0174	glutamine synthetase