locus-tag	class	description
wHa_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
wHa_00040	COG3736	Type IV secretory pathway, component VirB8
wHa_00070	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
wHa_00100	COG2890	protein-(glutamine-N5) methyltransferase activity
wHa_00110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
wHa_00120	COG0049	tRNA binding
wHa_00130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
wHa_00140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
wHa_00160	COG0250	Participates in transcription elongation, termination and antitermination
wHa_00170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
wHa_00180	COG0081	regulation of translation
wHa_00190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
wHa_00210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
wHa_00210	COG0085	RNA polymerase activity
wHa_00220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
wHa_00240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
wHa_00280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
wHa_00290	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
wHa_00300	COG0823	Involved in the tonB-independent uptake of proteins
wHa_00390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
wHa_00410	COG0776	regulation of translation
wHa_00470	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
wHa_00520	COG3827	peptidoglycan binding
wHa_00530	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
wHa_00550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
wHa_00560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
wHa_00570	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
wHa_00590	COG1845	cytochrome c oxidase, subunit III
wHa_00610	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
wHa_00620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
wHa_00660	COG3932	Exopolysaccharide synthesis, ExoD
wHa_00680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
wHa_00690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
wHa_00710	COG0751	glycine-tRNA ligase activity
wHa_00720	COG0752	glycyl-tRNA synthetase alpha subunit
wHa_00740	COG0113	porphobilinogen synthase activity
wHa_00750	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
wHa_00780	COG1573	uracil-dna glycosylase
wHa_00790	COG0242	peptide deformylase activity
wHa_00820	COG0024	Methionine aminopeptidase
wHa_00830	COG0477	Major facilitator Superfamily
wHa_00870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
wHa_00880	COG0193	aminoacyl-tRNA hydrolase activity
wHa_00900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
wHa_01030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
wHa_01040	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
wHa_01060	COG0307	riboflavin synthase, alpha
wHa_01120	COG1674	ftsk spoiiie
wHa_01210	COG0187	DNA topoisomerase II activity
wHa_01230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
wHa_01250	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
wHa_01260	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
wHa_01270	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
wHa_01270	COG0506	proline dehydrogenase activity
wHa_01270	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
wHa_01290	COG2076	Multidrug Resistance protein
wHa_01310	COG1686	Belongs to the peptidase S11 family
wHa_01320	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
wHa_01350	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
wHa_01360	COG0758	DNA mediated transformation
wHa_01370	COG0149	triose-phosphate isomerase activity
wHa_01410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
wHa_01420	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
wHa_01470	COG0237	dephospho-CoA kinase activity
wHa_01480	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
wHa_01530	COG1253	flavin adenine dinucleotide binding
wHa_01540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
wHa_01540	COG0519	Catalyzes the synthesis of GMP from XMP
wHa_01550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
wHa_01550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
wHa_01580	COG0230	Belongs to the bacterial ribosomal protein bL34 family
wHa_01590	COG0573	inorganic phosphate transmembrane transporter activity
wHa_01600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
wHa_01610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
wHa_01650	COG2814	Major facilitator Superfamily
wHa_01660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
wHa_01670	COG0218	Necessary for normal cell division and for the maintenance of normal septation
wHa_01680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
wHa_01690	COG0756	dUTP diphosphatase activity
wHa_01720	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
wHa_01740	COG3577	Aspartyl protease
wHa_01770	COG1138	Cytochrome C-type biogenesis protein
wHa_01800	COG1301	dicarboxylic acid transport
wHa_01810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
wHa_01850	COG0542	response to heat
wHa_01860	COG2902	Dehydrogenase
wHa_01880	COG0745	RESPONSE REGULATOR receiver
wHa_01880	COG3706	GGDEF domain
wHa_01980	COG0235	Class ii aldolase
wHa_02000	COG1322	Protein conserved in bacteria
wHa_02060	COG0697	spore germination
wHa_02110	COG1132	(ABC) transporter
wHa_02150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
wHa_02160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
wHa_02170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
wHa_02230	COG2189	Belongs to the N(4) N(6)-methyltransferase family
wHa_02240	COG2801	Transposase and inactivated derivatives
wHa_02320	COG1396	sequence-specific DNA binding
wHa_02380	COG2189	Belongs to the N(4) N(6)-methyltransferase family
wHa_02740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
wHa_02790	COG0154	amidase activity
wHa_02800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
wHa_02850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
wHa_02880	COG0114	fumarate hydratase activity
wHa_02920	COG0281	malic enzyme
wHa_02920	COG0280	phosphate acetyltransferase
wHa_02930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
wHa_02950	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
wHa_02970	COG0739	heme binding
wHa_03060	COG0508	dehydrogenase complex catalyzes the overall conversion of
wHa_03060	COG0022	dehydrogenase e1 component
wHa_03070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
wHa_03090	COG0477	Major facilitator Superfamily
wHa_03100	COG0590	tRNA wobble adenosine to inosine editing
wHa_03110	COG0504	CTP synthase activity
wHa_03150	COG0525	valine-tRNA ligase activity
wHa_03190	COG0284	orotidine-5'-phosphate decarboxylase activity
wHa_03220	COG1126	abc transporter atp-binding protein
wHa_03230	COG0765	amino acid transport
wHa_03240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
wHa_03250	COG1438	arginine binding
wHa_03260	COG0805	protein transport
wHa_03270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
wHa_03310	COG0617	tRNA 3'-terminal CCA addition
wHa_03330	COG0012	GTP binding
wHa_03360	COG0194	GDP metabolic process
wHa_03380	COG1053	succinate dehydrogenase
wHa_03870	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
wHa_03920	COG0653	protein targeting
wHa_03940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
wHa_03960	COG0439	Biotin carboxylase
wHa_04010	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
wHa_04020	COG0356	it plays a direct role in the translocation of protons across the membrane
wHa_04040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
wHa_04040	COG0072	phenylalanine-tRNA ligase activity
wHa_04060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
wHa_04080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
wHa_04100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
wHa_04110	COG0564	pseudouridine synthase activity
wHa_04120	COG0477	Major facilitator Superfamily
wHa_04150	COG4133	protoheme IX ABC transporter activity
wHa_04200	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
wHa_04220	COG0575	Belongs to the CDS family
wHa_04250	COG0528	UMP kinase activity
wHa_04270	COG0052	Belongs to the universal ribosomal protein uS2 family
wHa_04280	COG1862	Preprotein translocase
wHa_04310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
wHa_04330	COG0508	dehydrogenase complex catalyzes the overall conversion of
wHa_04350	COG0653	protein targeting
wHa_04370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
wHa_04430	COG2801	Transposase and inactivated derivatives
wHa_04450	COG0163	prenyltransferase activity
wHa_04460	COG3750	Belongs to the UPF0335 family
wHa_04470	COG4536	flavin adenine dinucleotide binding
wHa_04480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
wHa_04490	COG0649	NAD binding
wHa_04510	COG0018	arginyl-trna synthetase
wHa_04550	COG1132	(ABC) transporter
wHa_04580	COG2226	methyltransferase
wHa_04590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
wHa_04600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
wHa_04630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
wHa_04640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
wHa_04660	COG2814	Major facilitator Superfamily
wHa_04700	COG0717	Belongs to the dCTP deaminase family
wHa_04730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
wHa_04740	COG2239	Acts as a magnesium transporter
wHa_04750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
wHa_04780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
wHa_04820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
wHa_04850	COG1074	ATP-dependent DNA helicase activity
wHa_04860	COG2003	Belongs to the UPF0758 family
wHa_04870	COG1714	RDD family
wHa_04880	COG0305	Participates in initiation and elongation during chromosome replication
wHa_04910	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
wHa_04930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
wHa_04940	COG0358	DNA primase activity
wHa_04990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
wHa_05000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
wHa_05010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
wHa_05100	COG1115	amino acid carrier protein
wHa_05130	COG0459	protein refolding
wHa_05150	COG0354	folic acid binding
wHa_05160	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
wHa_05170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
wHa_05190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
wHa_05200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
wHa_05220	COG0544	peptidyl-prolyl cis-trans isomerase activity
wHa_05250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
wHa_05270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
wHa_05330	COG0109	protoheme IX farnesyltransferase activity
wHa_05340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
wHa_05350	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
wHa_05460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
wHa_05510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
wHa_05530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
wHa_05540	COG0792	nuclease activity
wHa_05550	COG0203	ribosomal protein L17
wHa_05560	COG0202	RNA polymerase activity
wHa_05570	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
wHa_05580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
wHa_05600	COG0201	protein transport
wHa_05610	COG0200	Binds to the 23S rRNA
wHa_05620	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
wHa_05630	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
wHa_05640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
wHa_05650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
wHa_05660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
wHa_05670	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
wHa_05680	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
wHa_05690	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
wHa_05700	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
wHa_05720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
wHa_05730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
wHa_05740	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
wHa_05750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
wHa_05760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
wHa_05790	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
wHa_05810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
wHa_05820	COG0505	Belongs to the CarA family
wHa_05850	COG1494	fructose-1,6-bisphosphatase
wHa_05870	COG0574	Belongs to the PEP-utilizing enzyme family
wHa_05870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
wHa_05890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
wHa_05930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
wHa_05950	COG1104	cysteine desulfurase activity
wHa_05960	COG2945	thiolester hydrolase activity
wHa_05990	COG0316	Belongs to the HesB IscA family
wHa_06000	COG0232	Belongs to the dGTPase family. Type 2 subfamily
wHa_06010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
wHa_06010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
wHa_06030	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
wHa_06050	COG2171	N-acyltransferase activity
wHa_06100	COG0768	penicillin binding
wHa_06120	COG0606	chelatase, subunit chli
wHa_06160	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
wHa_06170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
wHa_06190	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
wHa_06210	COG0745	RESPONSE REGULATOR receiver
wHa_06230	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
wHa_06240	COG0343	queuine tRNA-ribosyltransferase activity
wHa_06260	COG0612	Peptidase, M16
wHa_06270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
wHa_06280	COG1271	oxidase subunit
wHa_06290	COG1294	oxidase, subunit
wHa_06310	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
wHa_06380	COG4974	Belongs to the 'phage' integrase family
wHa_06410	COG0450	alkyl hydroperoxide reductase
wHa_06440	COG0196	riboflavin kinase activity
wHa_06450	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
wHa_06460	COG0612	Peptidase, M16
wHa_06480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
wHa_06520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
wHa_06580	COG0629	single-stranded DNA binding
wHa_06590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
wHa_06600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
wHa_06610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
wHa_06620	COG0587	DNA-directed DNA polymerase activity
wHa_06630	COG0360	Binds together with S18 to 16S ribosomal RNA
wHa_06640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
wHa_06660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
wHa_06680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
wHa_06690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
wHa_06700	COG0473	3-isopropylmalate dehydrogenase activity
wHa_06730	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
wHa_06760	COG0228	four-way junction DNA binding
wHa_06770	COG0142	geranyltranstransferase activity
wHa_06810	COG3474	cytochrome
wHa_06920	COG0009	L-threonylcarbamoyladenylate synthase
wHa_06960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
wHa_07040	COG0330	HflC and HflK could
wHa_07140	COG0556	nucleotide-excision repair
wHa_07180	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
wHa_07190	COG0552	protein localization to endoplasmic reticulum
wHa_07200	COG0822	iron-sulfur transferase activity
wHa_07210	COG0316	Belongs to the HesB IscA family
wHa_07230	COG0443	Heat shock 70 kDa protein
wHa_07240	COG0681	Belongs to the peptidase S26 family
wHa_07250	COG0540	Belongs to the ATCase OTCase family
wHa_07260	COG1840	ABC-type Fe3 transport system, periplasmic component
wHa_07310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
wHa_07340	COG0742	ribosomal rna small subunit methyltransferase
wHa_07360	COG3704	protein secretion by the type IV secretion system
wHa_07360	COG0419	ATPase involved in DNA repair
wHa_07370	COG3704	protein secretion by the type IV secretion system
wHa_07380	COG3704	protein secretion by the type IV secretion system
wHa_07390	COG3704	protein secretion by the type IV secretion system
wHa_07400	COG3451	type IV secretory pathway VirB4
wHa_07420	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
wHa_07430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
wHa_07450	COG0291	Belongs to the bacterial ribosomal protein bL35 family
wHa_07480	COG0138	bifunctional purine biosynthesis protein purh
wHa_07490	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
wHa_07500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
wHa_07510	COG0254	rRNA binding
wHa_07520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
wHa_07550	COG1185	polyribonucleotide nucleotidyltransferase activity
wHa_07570	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
wHa_07600	COG4235	cytochrome complex assembly
wHa_07600	COG3088	subunit of a heme lyase
wHa_07640	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
wHa_07640	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
wHa_07650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
wHa_07650	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
wHa_07670	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
wHa_07720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
wHa_07780	COG0626	cystathionine gamma-synthase activity
wHa_07810	COG1530	ribonuclease E activity
wHa_07820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
wHa_07840	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
wHa_07850	COG1121	(ABC) transporter
wHa_07860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
wHa_07930	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
wHa_07940	COG0670	Belongs to the BI1 family
wHa_07950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
wHa_07970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
wHa_08000	COG0531	amino acid
wHa_08020	COG0527	aspartate kinase activity
wHa_08070	COG0839	Belongs to the complex I subunit 6 family
wHa_08080	COG0713	ATP synthesis coupled electron transport
wHa_08090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
wHa_08100	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
wHa_08110	COG1007	ATP synthesis coupled electron transport
wHa_08120	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
wHa_08120	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
wHa_08170	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
wHa_08180	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
wHa_08190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
wHa_08200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
wHa_08220	COG0492	ferredoxin-NADP+ reductase activity
wHa_08230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
wHa_08250	COG0333	Belongs to the bacterial ribosomal protein bL32 family
wHa_08260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
wHa_08270	COG1127	ABC transporter
wHa_08290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
wHa_08310	COG1104	cysteine desulfurase activity
wHa_08320	COG0312	modulator of DNA gyrase
wHa_08370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
wHa_08370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
wHa_08430	COG0445	tRNA wobble uridine modification
wHa_08460	COG4695	Portal protein
wHa_08490	COG0321	lipoyl(octanoyl) transferase activity
wHa_08520	COG0047	phosphoribosylformylglycinamidine synthase activity
wHa_08540	COG0335	large ribosomal subunit rRNA binding
wHa_08570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
wHa_08600	COG1253	flavin adenine dinucleotide binding
wHa_08640	COG0477	Major facilitator Superfamily
wHa_08660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
wHa_08690	COG1230	cation diffusion facilitator family transporter
wHa_08710	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
wHa_08720	COG1115	amino acid carrier protein
wHa_08730	COG1115	amino acid carrier protein
wHa_08740	COG1183	phosphatidylcholine synthase activity
wHa_08750	COG0688	phosphatidylethanolamine metabolic process
wHa_08760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
wHa_08770	COG0484	heat shock protein binding
wHa_08780	COG0285	dihydrofolate synthase activity
wHa_08800	COG2867	negative regulation of translational initiation
wHa_08810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
wHa_08850	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
wHa_08860	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
wHa_08890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
wHa_08910	COG0592	DNA-directed DNA polymerase activity
wHa_08940	COG2857	Cytochrome c1
wHa_08940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
wHa_08950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
wHa_08970	COG0484	heat shock protein binding
wHa_08990	COG0124	histidyl-tRNA synthetase
wHa_09010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
wHa_09030	COG0493	'glutamate synthase
wHa_09030	COG0543	2 iron, 2 sulfur cluster binding
wHa_09070	COG0750	zinc metalloprotease
wHa_09100	COG0776	regulation of translation
wHa_09110	COG0539	negative regulation of cytoplasmic translation
wHa_09120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
wHa_09140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
wHa_09170	COG1160	GTP binding
wHa_09260	COG0651	ATP synthesis coupled electron transport
wHa_09270	COG0772	Belongs to the SEDS family
wHa_09280	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
wHa_09290	COG2094	Belongs to the DNA glycosylase MPG family
wHa_09310	COG2255	four-way junction helicase activity
wHa_09340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
wHa_09380	COG0084	hydrolase, TatD family'
wHa_09390	COG0039	L-malate dehydrogenase activity
wHa_09400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
wHa_09410	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
wHa_09420	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
wHa_09470	COG1090	epimerase
wHa_09490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
wHa_09520	COG1178	ABC-type Fe3 transport system permease component
wHa_09540	COG2967	ApaG domain
wHa_09550	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
wHa_09560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
wHa_09560	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
wHa_09570	COG0628	permease
wHa_09600	COG4974	Belongs to the 'phage' integrase family
wHa_09630	COG0372	Belongs to the citrate synthase family
wHa_09660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
wHa_09670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
wHa_09680	COG0259	pyridoxamine-phosphate oxidase activity
wHa_09690	COG2333	competence protein COMEC
wHa_09690	COG0658	competence protein
wHa_09710	COG0564	pseudouridine synthase activity
wHa_09740	COG0126	phosphoglycerate kinase activity
wHa_09760	COG2070	2-Nitropropane dioxygenase
wHa_09790	COG3451	type IV secretory pathway VirB4
wHa_09830	COG0508	dehydrogenase complex catalyzes the overall conversion of
wHa_09860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
wHa_09870	COG0105	UTP biosynthetic process
wHa_09890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
wHa_09920	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
wHa_09930	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
wHa_09950	COG0142	geranyltranstransferase activity
wHa_09960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
wHa_09970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
wHa_10000	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
wHa_10030	COG0723	plastoquinol--plastocyanin reductase activity
wHa_10070	COG1268	BioY protein
wHa_10080	COG0778	Nitroreductase
wHa_10110	COG0045	succinate-CoA ligase (ADP-forming) activity
wHa_10130	COG1385	rRNA (uridine-N3-)-methyltransferase activity
wHa_10170	COG1192	Involved in chromosome partitioning
wHa_10180	COG1475	DNA binding
wHa_10200	COG2009	succinate dehydrogenase
wHa_10210	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
wHa_10240	COG4591	ABC-type transport system involved in lipoprotein release permease component
wHa_10270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
wHa_10280	COG0312	modulator of DNA gyrase
wHa_10290	COG1278	Cold shock
wHa_10300	COG0513	Belongs to the DEAD box helicase family
wHa_10320	COG1830	Aldolase
wHa_10330	COG0167	dihydroorotate dehydrogenase activity
wHa_10340	COG0571	ribonuclease III activity
wHa_10440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
wHa_10460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
wHa_10480	COG2885	chlorophyll binding
wHa_10530	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
wHa_10550	COG0543	2 iron, 2 sulfur cluster binding
wHa_10550	COG0493	'glutamate synthase
wHa_10580	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
wHa_10610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
wHa_10620	COG0326	Molecular chaperone. Has ATPase activity
wHa_10640	COG0156	8-amino-7-oxononanoate synthase activity
wHa_10670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
wHa_10680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
wHa_10690	COG2202	Pas domain
wHa_10690	COG2205	protein histidine kinase activity
wHa_10700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
wHa_10710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
wHa_10750	COG1295	ribonuclease BN
wHa_10760	COG1028	Short-chain dehydrogenase reductase Sdr
wHa_10800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
wHa_10810	COG1006	Multisubunit Na H antiporter MnhC subunit
wHa_10830	COG2111	Na H antiporter
wHa_10830	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
wHa_10860	COG1758	RNA polymerase activity
wHa_10880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
wHa_10900	COG0567	Dehydrogenase, E1 component
wHa_10960	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
wHa_10970	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
wHa_10980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
wHa_10990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
wHa_11010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
wHa_11030	COG0174	glutamine synthetase