locus-tag	class	description
WwMa_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WwMa_00030	COG3577	Aspartyl protease
WwMa_00080	COG0756	dUTP diphosphatase activity
WwMa_00140	COG0736	holo-[acyl-carrier-protein] synthase activity
WwMa_00180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WwMa_00210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WwMa_00250	COG0284	orotidine-5'-phosphate decarboxylase activity
WwMa_00280	COG0525	valine-tRNA ligase activity
WwMa_00300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WwMa_00340	COG4974	Belongs to the 'phage' integrase family
WwMa_00350	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WwMa_00360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WwMa_00370	COG1981	membrane
WwMa_00380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WwMa_00390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WwMa_00400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WwMa_00410	COG0109	protoheme IX farnesyltransferase activity
WwMa_00450	COG0215	cysteine-tRNA ligase activity
WwMa_00460	COG3932	Exopolysaccharide synthesis, ExoD
WwMa_00490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WwMa_00500	COG3842	ATPase activity
WwMa_00520	COG1494	fructose-1,6-bisphosphatase
WwMa_00540	COG0012	GTP binding
WwMa_00570	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WwMa_00610	COG2816	NAD+ diphosphatase activity
WwMa_00630	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WwMa_00650	COG2814	Major facilitator Superfamily
WwMa_00660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WwMa_00690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WwMa_00810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WwMa_00830	COG0575	Belongs to the CDS family
WwMa_00860	COG0508	dehydrogenase complex catalyzes the overall conversion of
WwMa_00900	COG0542	response to heat
WwMa_00910	COG2902	Dehydrogenase
WwMa_00940	COG1381	Involved in DNA repair and RecF pathway recombination
WwMa_00970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WwMa_01020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WwMa_01030	COG0459	protein refolding
WwMa_01050	COG1115	amino acid carrier protein
WwMa_01070	COG0424	maF-like protein
WwMa_01190	COG0450	alkyl hydroperoxide reductase
WwMa_01220	COG1138	Cytochrome C-type biogenesis protein
WwMa_01240	COG2003	Belongs to the UPF0758 family
WwMa_01250	COG1686	Belongs to the peptidase S11 family
WwMa_01260	COG1322	Protein conserved in bacteria
WwMa_01300	COG0653	protein targeting
WwMa_01330	COG0758	DNA mediated transformation
WwMa_01340	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WwMa_01370	COG1181	Belongs to the D-alanine--D-alanine ligase family
WwMa_01420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WwMa_01440	COG2003	Belongs to the UPF0758 family
WwMa_01510	COG3621	Patatin-like phospholipase
WwMa_01750	COG2239	Acts as a magnesium transporter
WwMa_01760	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WwMa_01790	COG0564	pseudouridine synthase activity
WwMa_01810	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WwMa_01860	COG0805	protein transport
WwMa_01920	COG0617	tRNA 3'-terminal CCA addition
WwMa_01930	COG1217	gtp-binding protein TYPA
WwMa_01940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WwMa_01940	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WwMa_01970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WwMa_02000	COG1074	ATP-dependent DNA helicase activity
WwMa_02010	COG3088	subunit of a heme lyase
WwMa_02060	COG0358	DNA primase activity
WwMa_02070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WwMa_02110	COG0235	Class ii aldolase
WwMa_02170	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WwMa_02200	COG1674	ftsk spoiiie
WwMa_02240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WwMa_02250	COG0148	phosphopyruvate hydratase activity
WwMa_02280	COG3346	SURF1 family
WwMa_02350	COG0114	fumarate hydratase activity
WwMa_02380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WwMa_02400	COG0484	heat shock protein binding
WwMa_02430	COG0823	Involved in the tonB-independent uptake of proteins
WwMa_02440	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WwMa_02450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WwMa_02460	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WwMa_02470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WwMa_02500	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WwMa_02510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WwMa_02530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WwMa_02600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WwMa_02650	COG0022	dehydrogenase e1 component
WwMa_02650	COG0508	dehydrogenase complex catalyzes the overall conversion of
WwMa_02670	COG0681	Belongs to the peptidase S26 family
WwMa_02680	COG0443	Heat shock 70 kDa protein
WwMa_02700	COG0316	Belongs to the HesB IscA family
WwMa_02710	COG0822	iron-sulfur transferase activity
WwMa_02720	COG0552	protein localization to endoplasmic reticulum
WwMa_02730	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WwMa_02740	COG0477	Major facilitator Superfamily
WwMa_02750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WwMa_02780	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
WwMa_02810	COG3736	Type IV secretory pathway, component VirB8
WwMa_02850	COG3344	reverse transcriptase
WwMa_02890	COG4974	Belongs to the 'phage' integrase family
WwMa_02910	COG0268	Binds directly to 16S ribosomal RNA
WwMa_02920	COG0372	Belongs to the citrate synthase family
WwMa_02950	COG2827	Endonuclease containing a URI domain
WwMa_02980	COG2255	four-way junction helicase activity
WwMa_02990	COG0632	four-way junction helicase activity
WwMa_03000	COG3474	cytochrome
WwMa_03040	COG0839	Belongs to the complex I subunit 6 family
WwMa_03050	COG0713	ATP synthesis coupled electron transport
WwMa_03060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WwMa_03070	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WwMa_03080	COG1007	ATP synthesis coupled electron transport
WwMa_03090	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WwMa_03090	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WwMa_03110	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WwMa_03140	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WwMa_03150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WwMa_03160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WwMa_03170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WwMa_03190	COG0492	ferredoxin-NADP+ reductase activity
WwMa_03330	COG3344	reverse transcriptase
WwMa_03360	COG0489	protein tyrosine kinase activity
WwMa_03390	COG0799	negative regulation of ribosome biogenesis
WwMa_03400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WwMa_03460	COG3344	reverse transcriptase
WwMa_03490	COG0717	Belongs to the dCTP deaminase family
WwMa_03500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WwMa_03530	COG0233	cytoplasmic translational termination
WwMa_03540	COG0528	UMP kinase activity
WwMa_03550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WwMa_03560	COG0052	Belongs to the universal ribosomal protein uS2 family
WwMa_03570	COG1862	Preprotein translocase
WwMa_03610	COG4451	ribulose bisphosphate carboxylase, small
WwMa_03610	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WwMa_03630	COG0504	CTP synthase activity
WwMa_03650	COG0590	tRNA wobble adenosine to inosine editing
WwMa_03680	COG4133	protoheme IX ABC transporter activity
WwMa_03690	COG0018	arginyl-trna synthetase
WwMa_03720	COG1132	(ABC) transporter
WwMa_03740	COG2814	Major facilitator Superfamily
WwMa_03800	COG0739	heme binding
WwMa_03810	COG0217	transcriptional regulatory protein
WwMa_03840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WwMa_03850	COG0280	phosphate acetyltransferase
WwMa_03850	COG0281	malic enzyme
WwMa_03870	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WwMa_03880	COG1566	PFAM secretion protein HlyD family protein
WwMa_03900	COG0574	Belongs to the PEP-utilizing enzyme family
WwMa_03900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WwMa_03980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WwMa_03990	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WwMa_04000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WwMa_04010	COG0792	nuclease activity
WwMa_04020	COG0203	ribosomal protein L17
WwMa_04030	COG0202	RNA polymerase activity
WwMa_04040	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WwMa_04050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WwMa_04060	COG0563	adenylate kinase activity
WwMa_04070	COG0201	protein transport
WwMa_04080	COG0200	Binds to the 23S rRNA
WwMa_04090	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WwMa_04100	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WwMa_04110	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WwMa_04120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WwMa_04130	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WwMa_04140	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WwMa_04150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WwMa_04160	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WwMa_04180	COG0255	Belongs to the universal ribosomal protein uL29 family
WwMa_04190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WwMa_04200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WwMa_04210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WwMa_04220	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WwMa_04230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WwMa_04250	COG0088	Forms part of the polypeptide exit tunnel
WwMa_04260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WwMa_04270	COG0051	transcription antitermination factor activity, RNA binding
WwMa_04280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WwMa_04330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WwMa_04340	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WwMa_04350	COG0573	inorganic phosphate transmembrane transporter activity
WwMa_04355	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WwMa_04400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WwMa_04400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WwMa_04430	COG1845	cytochrome c oxidase, subunit III
WwMa_04450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WwMa_04460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WwMa_04470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WwMa_04480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WwMa_04510	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WwMa_04520	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WwMa_04540	COG0307	riboflavin synthase, alpha
WwMa_04560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WwMa_04620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WwMa_04620	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WwMa_04630	COG0154	amidase activity
WwMa_04640	COG0187	DNA topoisomerase II activity
WwMa_04680	COG1183	phosphatidylcholine synthase activity
WwMa_04690	COG1115	amino acid carrier protein
WwMa_04700	COG1115	amino acid carrier protein
WwMa_04710	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WwMa_04730	COG1230	cation diffusion facilitator family transporter
WwMa_04740	COG0484	heat shock protein binding
WwMa_04810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WwMa_04830	COG0322	excinuclease ABC activity
WwMa_04840	COG0751	glycine-tRNA ligase activity
WwMa_04850	COG0752	glycyl-tRNA synthetase alpha subunit
WwMa_04870	COG0113	porphobilinogen synthase activity
WwMa_04880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WwMa_04890	COG1034	ATP synthesis coupled electron transport
WwMa_04910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WwMa_04940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WwMa_04950	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WwMa_04970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WwMa_04990	COG0571	ribonuclease III activity
WwMa_05000	COG0167	dihydroorotate dehydrogenase activity
WwMa_05020	COG1830	Aldolase
WwMa_05040	COG0542	response to heat
WwMa_05050	COG0513	Belongs to the DEAD box helicase family
WwMa_05060	COG1278	Cold shock
WwMa_05070	COG0312	modulator of DNA gyrase
WwMa_05080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WwMa_05110	COG4591	ABC-type transport system involved in lipoprotein release permease component
WwMa_05140	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WwMa_05150	COG2009	succinate dehydrogenase
WwMa_05180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WwMa_05190	COG1006	Multisubunit Na H antiporter MnhC subunit
WwMa_05210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WwMa_05210	COG2111	Na H antiporter
WwMa_05220	COG1320	monovalent cation:proton antiporter activity
WwMa_05240	COG1758	RNA polymerase activity
WwMa_05260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WwMa_05290	COG0330	HflC and HflK could
WwMa_05340	COG0494	nUDIX hydrolase
WwMa_05350	COG0084	hydrolase, TatD family'
WwMa_05360	COG0039	L-malate dehydrogenase activity
WwMa_05370	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WwMa_05380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WwMa_05390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WwMa_05400	COG0537	adenosine 5'-monophosphoramidase activity
WwMa_05440	COG1090	epimerase
WwMa_05450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WwMa_05460	COG0416	fatty acid biosynthetic process
WwMa_05470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WwMa_05480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WwMa_05490	COG3842	ATPase activity
WwMa_05500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WwMa_05520	COG0493	'glutamate synthase
WwMa_05520	COG0543	2 iron, 2 sulfur cluster binding
WwMa_05560	COG0750	zinc metalloprotease
WwMa_05590	COG0776	regulation of translation
WwMa_05600	COG0539	negative regulation of cytoplasmic translation
WwMa_05610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WwMa_05660	COG2094	Belongs to the DNA glycosylase MPG family
WwMa_05690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WwMa_05730	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WwMa_05740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WwMa_05750	COG0336	Belongs to the RNA methyltransferase TrmD family
WwMa_05760	COG0335	large ribosomal subunit rRNA binding
WwMa_05770	COG0581	inorganic phosphate transmembrane transporter activity
WwMa_05780	COG0047	phosphoribosylformylglycinamidine synthase activity
WwMa_05800	COG0259	pyridoxamine-phosphate oxidase activity
WwMa_05810	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WwMa_05830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WwMa_05880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WwMa_05900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WwMa_05920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WwMa_05930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WwMa_05970	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WwMa_05980	COG2333	competence protein COMEC
WwMa_05980	COG0658	competence protein
WwMa_06020	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WwMa_06030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WwMa_06040	COG1028	Short-chain dehydrogenase reductase Sdr
WwMa_06050	COG1295	ribonuclease BN
WwMa_06070	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WwMa_06120	COG2801	Transposase and inactivated derivatives
WwMa_06150	COG3344	reverse transcriptase
WwMa_06180	COG0156	8-amino-7-oxononanoate synthase activity
WwMa_06200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WwMa_06210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WwMa_06230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WwMa_06240	COG2205	protein histidine kinase activity
WwMa_06260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WwMa_06300	COG0508	dehydrogenase complex catalyzes the overall conversion of
WwMa_06330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WwMa_06350	COG2885	chlorophyll binding
WwMa_06380	COG0482	sulfurtransferase activity
WwMa_06400	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WwMa_06410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WwMa_06420	COG0543	2 iron, 2 sulfur cluster binding
WwMa_06420	COG0493	'glutamate synthase
WwMa_06450	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WwMa_06470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WwMa_06510	COG0629	single-stranded DNA binding
WwMa_06520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WwMa_06550	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WwMa_06560	COG0670	Belongs to the BI1 family
WwMa_06570	COG1104	cysteine desulfurase activity
WwMa_06580	COG2945	thiolester hydrolase activity
WwMa_06610	COG0316	Belongs to the HesB IscA family
WwMa_06620	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WwMa_06630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WwMa_06630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WwMa_06650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WwMa_06660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WwMa_06670	COG1185	polyribonucleotide nucleotidyltransferase activity
WwMa_06680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WwMa_06710	COG0126	phosphoglycerate kinase activity
WwMa_06720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WwMa_06760	COG2076	Multidrug Resistance protein
WwMa_06770	COG0436	Aminotransferase
WwMa_06780	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WwMa_06790	COG1253	flavin adenine dinucleotide binding
WwMa_06840	COG0651	ATP synthesis coupled electron transport
WwMa_06850	COG0772	Belongs to the SEDS family
WwMa_06860	COG1104	cysteine desulfurase activity
WwMa_06870	COG2003	Belongs to the UPF0758 family
WwMa_06960	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
WwMa_06970	COG1573	uracil-dna glycosylase
WwMa_06980	COG0242	peptide deformylase activity
WwMa_06990	COG0849	cell division
WwMa_07000	COG0024	Methionine aminopeptidase
WwMa_07020	COG0275	rRNA processing
WwMa_07040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WwMa_07060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WwMa_07070	COG0101	tRNA pseudouridine synthase activity
WwMa_07100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WwMa_07120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WwMa_07130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WwMa_07190	COG2867	negative regulation of translational initiation
WwMa_07210	COG0285	dihydrofolate synthase activity
WwMa_07240	COG0312	modulator of DNA gyrase
WwMa_07260	COG0723	plastoquinol--plastocyanin reductase activity
WwMa_07300	COG1268	BioY protein
WwMa_07340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WwMa_07350	COG0045	succinate-CoA ligase (ADP-forming) activity
WwMa_07370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WwMa_07420	COG1475	DNA binding
WwMa_07430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WwMa_07430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WwMa_07450	COG0628	permease
WwMa_07480	COG3344	reverse transcriptase
WwMa_07530	COG0326	Molecular chaperone. Has ATPase activity
WwMa_07560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WwMa_07610	COG0666	response to abiotic stimulus
WwMa_07630	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
WwMa_07640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WwMa_07650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WwMa_07660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WwMa_07670	COG0142	geranyltranstransferase activity
WwMa_07690	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WwMa_07700	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WwMa_07730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WwMa_07760	COG0105	UTP biosynthetic process
WwMa_07770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WwMa_07780	COG4536	flavin adenine dinucleotide binding
WwMa_07790	COG3750	Belongs to the UPF0335 family
WwMa_07800	COG0163	prenyltransferase activity
WwMa_07810	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WwMa_07830	COG0495	leucyl-tRNA aminoacylation
WwMa_07860	COG0776	regulation of translation
WwMa_07880	COG0556	nucleotide-excision repair
WwMa_07890	COG2857	Cytochrome c1
WwMa_07890	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WwMa_07900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WwMa_07940	COG0484	heat shock protein binding
WwMa_07960	COG0124	histidyl-tRNA synthetase
WwMa_07970	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WwMa_07990	COG0531	amino acid
WwMa_08020	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WwMa_08030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WwMa_08050	COG1178	ABC-type Fe3 transport system permease component
WwMa_08150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WwMa_08210	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
WwMa_08230	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WwMa_08230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WwMa_08280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WwMa_08300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WwMa_08310	COG0359	binds to the 23S rRNA
WwMa_08330	COG0360	Binds together with S18 to 16S ribosomal RNA
WwMa_08370	COG0321	lipoyl(octanoyl) transferase activity
WwMa_08450	COG0445	tRNA wobble uridine modification
WwMa_08520	COG3451	type IV secretory pathway VirB4
WwMa_08550	COG2070	2-Nitropropane dioxygenase
WwMa_08570	COG0649	NAD binding
WwMa_08580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WwMa_08590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WwMa_08600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WwMa_08620	COG0072	phenylalanine-tRNA ligase activity
WwMa_08620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WwMa_08640	COG0356	it plays a direct role in the translocation of protons across the membrane
WwMa_08650	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WwMa_08680	COG1215	transferase activity, transferring glycosyl groups
WwMa_08690	COG1612	heme a metabolic process
WwMa_08700	COG4770	biotin carboxylase activity
WwMa_08720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WwMa_08740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WwMa_08770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WwMa_08790	COG3827	peptidoglycan binding
WwMa_08800	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WwMa_08820	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WwMa_08840	COG3451	type IV secretory pathway VirB4
WwMa_08850	COG3704	protein secretion by the type IV secretion system
WwMa_08860	COG3704	protein secretion by the type IV secretion system
WwMa_08870	COG1340	protein secretion by the type IV secretion system
WwMa_08870	COG3704	protein secretion by the type IV secretion system
WwMa_08900	COG0742	ribosomal rna small subunit methyltransferase
WwMa_08910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WwMa_08920	COG0612	Peptidase, M16
WwMa_08940	COG0343	queuine tRNA-ribosyltransferase activity
WwMa_08950	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WwMa_08970	COG0745	RESPONSE REGULATOR receiver
WwMa_08980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WwMa_08990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WwMa_09020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WwMa_09030	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WwMa_09070	COG0606	chelatase, subunit chli
WwMa_09080	COG0726	polysaccharide deacetylase
WwMa_09090	COG0768	penicillin binding
WwMa_09100	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WwMa_09110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WwMa_09120	COG0740	serine-type endopeptidase activity
WwMa_09130	COG0544	peptidyl-prolyl cis-trans isomerase activity
WwMa_09160	COG2890	protein-(glutamine-N5) methyltransferase activity
WwMa_09160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WwMa_09170	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WwMa_09180	COG0049	tRNA binding
WwMa_09190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WwMa_09200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WwMa_09210	COG0250	Participates in transcription elongation, termination and antitermination
WwMa_09220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WwMa_09230	COG0081	regulation of translation
WwMa_09240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WwMa_09250	COG0222	ribosome binding
WwMa_09260	COG0085	RNA polymerase activity
WwMa_09260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WwMa_09270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WwMa_09290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WwMa_09320	COG0473	3-isopropylmalate dehydrogenase activity
WwMa_09340	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WwMa_09360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WwMa_09380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WwMa_09420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WwMa_09440	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WwMa_09450	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WwMa_09460	COG0254	rRNA binding
WwMa_09500	COG1840	ABC-type Fe3 transport system, periplasmic component
WwMa_09510	COG0540	Belongs to the ATCase OTCase family
WwMa_09540	COG0194	GDP metabolic process
WwMa_09560	COG1053	succinate dehydrogenase
WwMa_09580	COG2171	N-acyltransferase activity
WwMa_09640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WwMa_09680	COG2003	Belongs to the UPF0758 family
WwMa_09710	COG3344	reverse transcriptase
WwMa_09740	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WwMa_09750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WwMa_09790	COG1132	(ABC) transporter
WwMa_09840	COG0697	spore germination
WwMa_09870	COG0149	triose-phosphate isomerase activity
WwMa_09880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WwMa_09900	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WwMa_09930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WwMa_09940	COG0228	four-way junction DNA binding
WwMa_09950	COG0142	geranyltranstransferase activity
WwMa_09960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WwMa_09990	COG0567	Dehydrogenase, E1 component
WwMa_10060	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WwMa_10090	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WwMa_10100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WwMa_10140	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WwMa_10170	COG0612	Peptidase, M16
WwMa_10180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WwMa_10190	COG0196	riboflavin kinase activity
WwMa_10220	COG0481	GTPase activity
WwMa_10250	COG1253	flavin adenine dinucleotide binding
WwMa_10260	COG0519	Catalyzes the synthesis of GMP from XMP
WwMa_10260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WwMa_10270	COG1450	Type ii and iii secretion system protein
WwMa_10290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WwMa_10300	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WwMa_10310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WwMa_10320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WwMa_10340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WwMa_10380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WwMa_10400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WwMa_10420	COG1301	dicarboxylic acid transport
WwMa_10430	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WwMa_10600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WwMa_10610	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WwMa_10620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WwMa_10690	COG1121	(ABC) transporter
WwMa_10700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WwMa_10720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WwMa_10730	COG1530	ribonuclease E activity
WwMa_10740	COG0443	Heat shock 70 kDa protein
WwMa_10750	COG0271	Belongs to the BolA IbaG family
WwMa_10760	COG0626	cystathionine gamma-synthase activity
WwMa_10780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WwMa_10800	COG0009	L-threonylcarbamoyladenylate synthase
WwMa_10810	COG0470	DNA polymerase III
WwMa_10850	COG0305	Participates in initiation and elongation during chromosome replication
WwMa_10900	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WwMa_10910	COG0237	dephospho-CoA kinase activity
WwMa_10940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WwMa_11020	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WwMa_11030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex