locus-tag	class	description
wNo_00010	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
wNo_00020	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
wNo_00030	ENOG4108WIW	Aspartyl protease
wNo_00040	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
wNo_00050	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
wNo_00080	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
wNo_00140	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
wNo_00180	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
wNo_00210	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
wNo_00250	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
wNo_00290	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
wNo_00310	ENOG4108KAG	Cytochrome C oxidase, subunit I
wNo_00330	ENOG4107QN2	dihydrolipoyl dehydrogenase
wNo_00340	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
wNo_00350	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
wNo_00360	ENOG4108JYK	Dehydrogenase
wNo_00370	ENOG4108YXA	Membrane
wNo_00400	ENOG4105BZ9	Cytochrome C oxidase, subunit I
wNo_00410	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
wNo_00450	ENOG4105C8N	cysteinyl-tRNA synthetase
wNo_00470	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
wNo_00480	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
wNo_00500	ENOG4105CBT	Fructose-1,6-bisphosphatase
wNo_00520	ENOG4105C3G	gtp-binding protein
wNo_00550	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
wNo_00630	ENOG4105C2C	drug resistance transporter, Bcr CflA
wNo_00640	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
wNo_00680	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
wNo_00720	ENOG4108Z03	MAF-like protein
wNo_00760	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
wNo_00770	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
wNo_00780	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
wNo_00820	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
wNo_00850	ENOG4107UIS	Involved in DNA repair and RecF pathway recombination (By similarity)
wNo_00860	ENOG4105BZU	Histidine kinase
wNo_00880	ENOG4105C7I	Dehydrogenase
wNo_00890	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
wNo_00930	ENOG4105C7S	Dehydrogenase
wNo_00960	ENOG4105KNE	Phosphatidate cytidylyltransferase
wNo_00980	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
wNo_01410	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
wNo_01420	ENOG4105CK2	sodium dicarboxylate symporter
wNo_01440	ENOG4105D4A	Cell wall formation (By similarity)
wNo_01500	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
wNo_01520	ENOG4105CB5	ATP-dependent DNA helicase recG
wNo_01530	ENOG41087N0	50S ribosomal protein L36
wNo_01540	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
wNo_01550	ENOG41060IM	Heme exporter protein
wNo_01580	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
wNo_01590	ENOG4105EE5	Membrane protein terC
wNo_01620	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
wNo_01650	ENOG4105DTN	riboflavin biosynthesis protein ribF
wNo_01660	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
wNo_01700	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
wNo_01740	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
wNo_01750	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
wNo_01780	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
wNo_01850	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
wNo_01880	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
wNo_01890	ENOG4105EAH	synthase
wNo_01900	ENOG4105K5M	30s ribosomal protein S16
wNo_01910	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
wNo_01940	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
wNo_01950	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
wNo_01960	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
wNo_01970	ENOG4105CP7	Triose-phosphate isomerase
wNo_02000	ENOG4108JHT	EamA-like transporter family
wNo_02050	ENOG4105BZ1	(ABC) transporter
wNo_02090	ENOG4108IAJ	Nad-dependent epimerase dehydratase
wNo_02100	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
wNo_02120	ENOG4105EKQ	RNA-directed DNA polymerase
wNo_02130	ENOG4105EKQ	RNA-directed DNA polymerase
wNo_02170	ENOG4105W5Q	DNA repair protein (RadC
wNo_02210	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
wNo_02270	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
wNo_02310	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
wNo_02340	ENOG4105CXT	aspartate transcarbamylase
wNo_02370	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
wNo_02380	ENOG41082FS	50S ribosomal protein L31
wNo_02390	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
wNo_02400	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
wNo_02420	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
wNo_02460	ENOG41082BR	50S ribosomal protein L35
wNo_02480	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
wNo_02490	ENOG4105DC1	bifunctional purine biosynthesis protein purh
wNo_02500	ENOG4105CSM	endonuclease III
wNo_02550	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
wNo_02580	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
wNo_02590	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
wNo_02600	ENOG4108VZM	50s ribosomal protein L10
wNo_02610	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
wNo_02620	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
wNo_02630	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
wNo_02640	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
wNo_02650	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
wNo_02660	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
wNo_02670	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
wNo_02680	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
wNo_02700	ENOG41082WC	Transport-associated protein
wNo_02710	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
wNo_02720	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
wNo_02730	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
wNo_02740	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
wNo_02750	ENOG4105CJN	penicillin-binding protein
wNo_02770	ENOG4105C0P	Mg chelatase subunit ChlI
wNo_02810	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
wNo_02850	ENOG4108ZAI	phosphatidylglycerophosphatase a
wNo_02860	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
wNo_02870	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
wNo_02900	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
wNo_02920	ENOG4105C1V	Peptidase, M16
wNo_02940	ENOG4106H78	methyltransferase
wNo_02970	ENOG4108QTG	type IV secretion system protein
wNo_03040	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
wNo_03050	ENOG4106HA5	Protein of unknown function (DUF2497) 
wNo_03070	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
wNo_03100	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
wNo_03120	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
wNo_03140	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
wNo_03150	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
wNo_03160	ENOG4107R8N	Glycosyl transferase, family 2
wNo_03190	ENOG41085Y2	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
wNo_03200	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
wNo_03220	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
wNo_03240	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
wNo_03250	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
wNo_03260	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
wNo_03270	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
wNo_03290	ENOG4105EA8	2-Nitropropane dioxygenase
wNo_03380	ENOG4105DC7	peptidase M24
wNo_03390	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
wNo_03470	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
wNo_03500	ENOG4105C0B	DNA polymerase III (alpha subunit)
wNo_03510	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
wNo_03520	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
wNo_03530	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
wNo_03540	ENOG4105C83	adenylosuccinate lyase
wNo_03550	ENOG4108MDK	Dehydrogenase
wNo_03560	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
wNo_03610	ENOG4105EEI	dihydropteroate synthase
wNo_03630	ENOG4107ZH2	Coenzyme PQQ synthesis protein C
wNo_03660	ENOG4105K63	Thioredoxin
wNo_03690	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
wNo_03800	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
wNo_03810	ENOG4105NWN	ApaG protein
wNo_03820	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
wNo_03860	ENOG4105D5Q	Arginine ornithine antiporter
wNo_03880	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
wNo_03890	ENOG4105CUT	histidyl-tRNA synthetase
wNo_03910	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
wNo_03950	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
wNo_03960	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
wNo_03970	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
wNo_03990	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
wNo_04000	ENOG4105WJX	transcriptional regulator MERR family
wNo_04020	ENOG4105C8T	Leucyl-tRNA synthetase
wNo_04040	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
wNo_04050	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
wNo_04060	ENOG4105Y2X	UPF0335 protein
wNo_04070	ENOG4108JU6	CBS domain protein
wNo_04080	ENOG4105C8Y	Acetylornithine aminotransferase
wNo_04090	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
wNo_04120	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
wNo_04150	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
wNo_04160	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
wNo_04180	ENOG4105CTB	Polyprenyl synthetase
wNo_04190	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
wNo_04200	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
wNo_04210	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
wNo_04220	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
wNo_04260	ENOG4105C25	Primosomal protein n'
wNo_04290	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
wNo_04320	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
wNo_04360	ENOG4105EKQ	RNA-directed DNA polymerase
wNo_04400	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
wNo_04420	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
wNo_04430	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
wNo_04450	ENOG4105C8Y	Acetylornithine aminotransferase
wNo_04460	ENOG4105BZU	Histidine kinase
wNo_04480	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
wNo_04500	ENOG4108JJ6	Type I secretion system ATPase
wNo_04550	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
wNo_04570	ENOG4105KCK	Peptidoglycan-associated lipoprotein
wNo_04600	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
wNo_04630	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
wNo_04670	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
wNo_04690	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
wNo_04740	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
wNo_04770	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
wNo_04780	ENOG4105HFZ	Membrane
wNo_04790	ENOG4107QI6	Cysteine desulfurase
wNo_04800	ENOG4105DHZ	alpha beta
wNo_04830	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
wNo_04840	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
wNo_04850	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
wNo_04870	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
wNo_04880	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
wNo_04890	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
wNo_04900	ENOG4105DJV	ribulose-phosphate 3-epimerase
wNo_04930	ENOG4105BZA	Phosphoglycerate kinase
wNo_04940	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
wNo_04970	ENOG4105KPY	Small multidrug resistance protein
wNo_04980	ENOG4105CHM	Aminotransferase
wNo_04990	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
wNo_05040	ENOG4108JPZ	Monovalent cation H antiporter subunit D
wNo_05050	ENOG4105CNI	cell division protein FtsW
wNo_05060	ENOG4105C3J	Cysteine desulfurase
wNo_05070	ENOG4105W5Q	DNA repair protein (RadC
wNo_05160	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
wNo_05170	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
wNo_05190	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
wNo_05200	ENOG4105CFH	Aspartokinase
wNo_05210	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
wNo_05220	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
wNo_05230	ENOG4105D7Z	glutathione synthase
wNo_05240	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
wNo_05290	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
wNo_05310	ENOG4107QX3	carboxylase
wNo_05340	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
wNo_05360	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
wNo_05370	ENOG4105E2Z	phosphate ABC transporter (Permease
wNo_05380	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
wNo_05390	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
wNo_05400	ENOG4107QPR	SAICAR synthetase
wNo_05410	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
wNo_05450	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
wNo_05480	ENOG4108VX5	3-methyladenine DNA glycosylase
wNo_05510	ENOG4105D1F	ATP-binding protein
wNo_05530	ENOG4105EKQ	RNA-directed DNA polymerase
wNo_05560	ENOG4105C02	permease
wNo_05580	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
wNo_05590	ENOG4105FA0	parb-like partition protein
wNo_05600	ENOG4107QJE	Chromosome Partitioning Protein
wNo_05620	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
wNo_05640	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
wNo_05660	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
wNo_05670	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
wNo_05700	ENOG4108RCM	Nitroreductase
wNo_05710	ENOG4107XYW	BioY family
wNo_05750	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
wNo_05770	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
wNo_05800	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
wNo_05820	ENOG4108Z1B	Cyclase dehydrase
wNo_05830	ENOG4107ZQN	disulfide bond
wNo_05880	ENOG4107QMP	dna polymerase iii subunits gamma and tau
wNo_05890	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
wNo_05900	ENOG4108UK9	heat resistant agglutinin 1
wNo_05930	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
wNo_05940	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
wNo_05950	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
wNo_05960	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
wNo_05970	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
wNo_05990	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
wNo_06010	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
wNo_06020	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
wNo_06030	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
wNo_06040	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
wNo_06120	ENOG4105EPW	hflc protein
wNo_06130	ENOG4107RIZ	hflk protein
wNo_06150	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
wNo_06170	ENOG41067UH	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
wNo_06190	ENOG4105KJM	monovalent cation h antiporter subunit g
wNo_06200	ENOG4105C8S	subunit m
wNo_06220	ENOG4105MKQ	Monovalent cation H antiporter subunit C
wNo_06230	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
wNo_06300	ENOG4105D60	lipoprotein releasing system transmembrane protein
wNo_06330	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
wNo_06340	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
wNo_06360	ENOG4105C1J	atp-dependent rna helicase
wNo_06370	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
wNo_06390	ENOG4105EIE	fructose-bisphosphate aldolase
wNo_06410	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
wNo_06420	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
wNo_06460	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
wNo_06470	ENOG4108I0Z	Aconitate hydratase
wNo_06500	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
wNo_06530	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
wNo_06540	ENOG4105D52	delta-aminolevulinic acid dehydratase
wNo_06560	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
wNo_06570	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
wNo_06580	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
wNo_06600	ENOG4105C2N	RNA methyltransferase TrmH family group 3
wNo_06650	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
wNo_06660	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
wNo_06730	ENOG4105EKQ	RNA-directed DNA polymerase
wNo_06760	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
wNo_06780	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
wNo_06790	ENOG4105BZN	citrate synthase
wNo_06810	ENOG4105VC4	domain protein
wNo_06830	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
wNo_06840	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
wNo_06850	ENOG4105G9V	cytochrome C
wNo_06890	ENOG4105DF2	NADH dehydrogenase subunit j
wNo_06900	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
wNo_06930	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
wNo_06940	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
wNo_06960	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
wNo_06990	ENOG4107QIZ	NADH dehydrogenase
wNo_07000	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
wNo_07010	ENOG4105C22	threonyL-tRNA synthetase
wNo_07020	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
wNo_07040	ENOG4105CAY	ferredoxin--nadp reductase
wNo_07090	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
wNo_07110	ENOG4107U9T	Pfam:Ribonuclease_BN
wNo_07120	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
wNo_07130	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
wNo_07140	ENOG41080IJ	Diacylglycerol kinase
wNo_07220	ENOG4105EKQ	RNA-directed DNA polymerase
wNo_07400	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
wNo_07410	ENOG4105F8V	Hydrolase, tatD family
wNo_07420	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
wNo_07430	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
wNo_07440	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
wNo_07450	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
wNo_07460	ENOG4105K59	histidine triad (HIT) protein
wNo_07500	ENOG4105ECP	epimerase
wNo_07510	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
wNo_07520	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
wNo_07540	ENOG4105CY3	ABC transporter, permease
wNo_07550	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
wNo_07610	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
wNo_07620	ENOG4105DZP	Membrane-associated zinc metalloprotease
wNo_07650	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
wNo_07660	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
wNo_07670	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
wNo_07740	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
wNo_07750	ENOG4105PGM	cation diffusion facilitator family transporter
wNo_07770	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
wNo_07780	ENOG4105BZG	amino acid carrier protein
wNo_07790	ENOG4105BZG	amino acid carrier protein
wNo_07800	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
wNo_07810	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
wNo_07850	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
wNo_07920	ENOG4107QKV	phosphomannomutase
wNo_07940	ENOG4108R6K	riboflavin synthase, subunit alpha
wNo_07960	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
wNo_07970	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
wNo_08000	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
wNo_08010	ENOG4105K46	50S ribosomal protein l27
wNo_08020	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
wNo_08030	ENOG4105ETU	transcriptional activator (TenA
wNo_08080	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
wNo_08130	ENOG4105C8U	phosphate abc transporter
wNo_08140	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
wNo_08150	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
wNo_08170	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
wNo_08190	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
wNo_08200	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
wNo_08210	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
wNo_08220	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
wNo_08230	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
wNo_08240	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
wNo_08250	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
wNo_08260	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
wNo_08270	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
wNo_08280	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
wNo_08290	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
wNo_08310	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
wNo_08320	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
wNo_08330	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
wNo_08340	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
wNo_08350	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
wNo_08360	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
wNo_08370	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
wNo_08380	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
wNo_08390	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
wNo_08400	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
wNo_08410	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
wNo_08420	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
wNo_08430	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
wNo_08440	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
wNo_08450	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
wNo_08460	ENOG4108ZT0	50S ribosomal protein l17
wNo_08470	ENOG41082FP	UPF0102 protein
wNo_08490	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
wNo_08500	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
wNo_08510	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
wNo_08570	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
wNo_08590	ENOG4105CW7	secretion protein, HlyD family
wNo_08600	ENOG4105M2J	Glutaredoxin
wNo_08620	ENOG4105C6K	Malic enzyme
wNo_08630	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
wNo_08660	ENOG4105CDY	transcriptional regulatory protein
wNo_08670	ENOG4105DR5	peptidase
wNo_08730	ENOG4105C2C	drug resistance transporter, Bcr CflA
wNo_08750	ENOG4105BZ1	(ABC) transporter
wNo_08780	ENOG4105C75	arginyL-tRNA synthetase
wNo_08790	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
wNo_08820	ENOG4108Z6B	deaminase
wNo_08840	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
wNo_08910	ENOG4105CE9	30S ribosomal protein S2
wNo_08920	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
wNo_08930	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
wNo_08940	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
wNo_08970	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
wNo_08980	ENOG4105DHP	deoxycytidine triphosphate deaminase
wNo_09000	ENOG4105EKQ	RNA-directed DNA polymerase
wNo_09050	ENOG4105CEC	DNA methylase N-4 N-6
wNo_09100	ENOG4105DFS	Conserved Protein
wNo_09200	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
wNo_09210	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
wNo_09220	ENOG4105CAS	nag kinase
wNo_09280	ENOG4105NXV	High-affinity zinc uptake system protein
wNo_09290	ENOG4105FDK	ABC transporter
wNo_09300	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
wNo_09330	ENOG4105C03	ribonuclease
wNo_09340	ENOG4105CFG	Acts as a chaperone (By similarity)
wNo_09350	ENOG4105M85	Bola protein
wNo_09360	ENOG4105C28	cystathionine
wNo_09370	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
wNo_09380	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
wNo_09400	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
wNo_09410	ENOG4107QRG	dna polymerase iii
wNo_09450	ENOG4105CDU	Replicative dna helicase
wNo_09520	ENOG4108UQY	Iron-storage protein
wNo_09530	ENOG4108R6F	Surfeit locus 1 family protein
wNo_09560	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
wNo_09570	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
wNo_09610	ENOG4105CNU	cell division protein FtsK
wNo_09640	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
wNo_09680	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
wNo_09700	ENOG4105MP9	class II Aldolase
wNo_09720	ENOG41072GX	Peptidase M22 Glycoprotease
wNo_09740	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
wNo_09750	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
wNo_09770	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
wNo_09800	ENOG4105KWW	Biogenesis protein
wNo_09810	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
wNo_09840	ENOG4105FAV	ABC, transporter
wNo_09870	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
wNo_09880	ENOG4105CI3	gtp-binding protein typa
wNo_09890	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
wNo_09940	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
wNo_09950	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
wNo_09990	ENOG4105C9M	aspartyl-trna synthetase
wNo_10000	ENOG4105CSH	Transporter
wNo_10040	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
wNo_10050	ENOG4105CJW	magnesium transporter
wNo_10350	ENOG4105W5Q	DNA repair protein (RadC
wNo_10370	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
wNo_10410	ENOG4105CPF	Cell wall formation (By similarity)
wNo_10430	ENOG4108Z4U	Ferredoxin
wNo_10440	ENOG4105C79	DNA protecting protein DprA
wNo_10460	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
wNo_10510	ENOG4105DZ1	carboxypeptidase
wNo_10520	ENOG4105W5Q	DNA repair protein (RadC
wNo_10540	ENOG4105DA4	cytochrome c-type biogenesis protein
wNo_10570	ENOG4105D3R	alkyl hydroperoxide reductase
wNo_10670	ENOG4105EKQ	RNA-directed DNA polymerase
wNo_10710	ENOG4107QJN	gtp cyclohydrolase ii
wNo_10720	ENOG4108V42	Type IV secretion system protein VirB8
wNo_10750	ENOG4108EHY	type IV secretion system
wNo_10790	ENOG4105CSH	Transporter
wNo_10810	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
wNo_10820	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
wNo_10830	ENOG4108Z4V	iron-sulfur cluster assembly
wNo_10850	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
wNo_10860	ENOG4105C3F	Signal peptidase i
wNo_10880	ENOG4105CPP	Dehydrogenase, E1 component
wNo_10930	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
wNo_11000	ENOG4108JDX	DNA polymerase iii, epsilon subunit
wNo_11020	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
wNo_11030	ENOG4105KDC	50s ribosomal protein l28
wNo_11050	ENOG4105WVQ	Fe-S assembly protein IscX
wNo_11060	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
wNo_11090	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
wNo_11100	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
wNo_11120	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
wNo_11140	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
wNo_11170	ENOG4105C9Q	fumarate hydratase class II
wNo_11210	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
wNo_11220	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
wNo_11250	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
wNo_11340	ENOG41082QS	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
wNo_11350	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)