locus-tag	class	description
wYak_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
wYak_00040	COG3736	Type IV secretory pathway, component VirB8
wYak_00070	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
wYak_00080	COG3505	Type IV secretory pathway VirD4
wYak_00100	COG2890	protein-(glutamine-N5) methyltransferase activity
wYak_00110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
wYak_00140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
wYak_00160	COG0250	Participates in transcription elongation, termination and antitermination
wYak_00170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
wYak_00180	COG0081	regulation of translation
wYak_00190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
wYak_00200	COG0222	ribosome binding
wYak_00210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
wYak_00210	COG0085	RNA polymerase activity
wYak_00220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
wYak_00240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
wYak_00300	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
wYak_00310	COG3827	peptidoglycan binding
wYak_00360	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
wYak_00390	COG0495	leucyl-tRNA aminoacylation
wYak_00420	COG0776	regulation of translation
wYak_00440	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
wYak_00530	COG0823	Involved in the tonB-independent uptake of proteins
wYak_00540	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
wYak_00550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
wYak_00610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
wYak_00660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
wYak_00670	COG0148	phosphopyruvate hydratase activity
wYak_00680	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
wYak_00690	COG0114	fumarate hydratase activity
wYak_00730	COG0280	phosphate acetyltransferase
wYak_00730	COG0281	malic enzyme
wYak_00740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
wYak_00760	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
wYak_00770	COG0217	transcriptional regulatory protein
wYak_00780	COG0739	heme binding
wYak_00830	COG0481	GTPase activity
wYak_00850	COG0022	dehydrogenase e1 component
wYak_00850	COG0508	dehydrogenase complex catalyzes the overall conversion of
wYak_00860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
wYak_00880	COG0477	Major facilitator Superfamily
wYak_00890	COG0590	tRNA wobble adenosine to inosine editing
wYak_00900	COG0504	CTP synthase activity
wYak_00940	COG0525	valine-tRNA ligase activity
wYak_00970	COG0284	orotidine-5'-phosphate decarboxylase activity
wYak_01000	COG1126	abc transporter atp-binding protein
wYak_01010	COG0765	amino acid transport
wYak_01020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
wYak_01030	COG1438	arginine binding
wYak_01040	COG0805	protein transport
wYak_01050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
wYak_01080	COG0617	tRNA 3'-terminal CCA addition
wYak_01100	COG0012	GTP binding
wYak_01130	COG0194	GDP metabolic process
wYak_01150	COG1053	succinate dehydrogenase
wYak_01160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
wYak_01180	COG4770	biotin carboxylase activity
wYak_01190	COG1612	heme a metabolic process
wYak_01230	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
wYak_01240	COG0356	it plays a direct role in the translocation of protons across the membrane
wYak_01260	COG0072	phenylalanine-tRNA ligase activity
wYak_01260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
wYak_01280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
wYak_01300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
wYak_01310	COG1981	membrane
wYak_01320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
wYak_01330	COG0564	pseudouridine synthase activity
wYak_01340	COG0477	Major facilitator Superfamily
wYak_01370	COG4133	protoheme IX ABC transporter activity
wYak_01410	COG0018	arginyl-trna synthetase
wYak_01430	COG1132	(ABC) transporter
wYak_01470	COG2226	methyltransferase
wYak_01480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
wYak_01490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
wYak_01530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
wYak_01550	COG2814	Major facilitator Superfamily
wYak_01630	COG2239	Acts as a magnesium transporter
wYak_01640	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
wYak_01670	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
wYak_01710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
wYak_01730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
wYak_01740	COG1074	ATP-dependent DNA helicase activity
wYak_01760	COG2003	Belongs to the UPF0758 family
wYak_01770	COG1714	RDD family
wYak_01780	COG0305	Participates in initiation and elongation during chromosome replication
wYak_01800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
wYak_01820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
wYak_01830	COG0358	DNA primase activity
wYak_01900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
wYak_01930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
wYak_01970	COG0424	maF-like protein
wYak_01990	COG1115	amino acid carrier protein
wYak_02080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
wYak_02130	COG0544	peptidyl-prolyl cis-trans isomerase activity
wYak_02140	COG0740	serine-type endopeptidase activity
wYak_02150	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
wYak_02160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
wYak_02180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
wYak_02190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
wYak_02200	COG0354	folic acid binding
wYak_02210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
wYak_02220	COG0459	protein refolding
wYak_02240	COG0328	RNA-DNA hybrid ribonuclease activity
wYak_02250	COG0109	protoheme IX farnesyltransferase activity
wYak_02260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
wYak_02270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
wYak_02400	COG1322	Protein conserved in bacteria
wYak_02420	COG0235	Class ii aldolase
wYak_02490	COG4804	nuclease activity
wYak_02510	COG1381	Involved in DNA repair and RecF pathway recombination
wYak_02540	COG2902	Dehydrogenase
wYak_02550	COG0542	response to heat
wYak_02580	COG1217	gtp-binding protein TYPA
wYak_02590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
wYak_02600	COG1301	dicarboxylic acid transport
wYak_02630	COG1138	Cytochrome C-type biogenesis protein
wYak_02660	COG3577	Aspartyl protease
wYak_02720	COG0756	dUTP diphosphatase activity
wYak_02730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
wYak_02740	COG0218	Necessary for normal cell division and for the maintenance of normal septation
wYak_02750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
wYak_02760	COG2814	Major facilitator Superfamily
wYak_02800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
wYak_02810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
wYak_02820	COG0573	inorganic phosphate transmembrane transporter activity
wYak_02870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
wYak_02870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
wYak_02890	COG1253	flavin adenine dinucleotide binding
wYak_02920	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
wYak_02930	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
wYak_02940	COG0237	dephospho-CoA kinase activity
wYak_02990	COG0489	protein tyrosine kinase activity
wYak_03010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
wYak_03030	COG0193	aminoacyl-tRNA hydrolase activity
wYak_03070	COG0275	rRNA processing
wYak_03080	COG0477	Major facilitator Superfamily
wYak_03090	COG0024	Methionine aminopeptidase
wYak_03100	COG0849	cell division
wYak_03110	COG0242	peptide deformylase activity
wYak_03120	COG1573	uracil-dna glycosylase
wYak_03150	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
wYak_03160	COG0113	porphobilinogen synthase activity
wYak_03180	COG0752	glycyl-tRNA synthetase alpha subunit
wYak_03200	COG0322	excinuclease ABC activity
wYak_03210	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
wYak_03220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
wYak_03240	COG3932	Exopolysaccharide synthesis, ExoD
wYak_03250	COG0215	cysteine-tRNA ligase activity
wYak_03280	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
wYak_03290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
wYak_03310	COG1845	cytochrome c oxidase, subunit III
wYak_03360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
wYak_03370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
wYak_03380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
wYak_03390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
wYak_03400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
wYak_03420	COG0307	riboflavin synthase, alpha
wYak_03520	COG1674	ftsk spoiiie
wYak_03550	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
wYak_03580	COG0187	DNA topoisomerase II activity
wYak_03600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
wYak_03630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
wYak_03680	COG1686	Belongs to the peptidase S11 family
wYak_03690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
wYak_03720	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
wYak_03730	COG0758	DNA mediated transformation
wYak_03740	COG0149	triose-phosphate isomerase activity
wYak_03750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
wYak_03780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
wYak_03790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
wYak_03890	COG0154	amidase activity
wYak_03960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
wYak_04010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
wYak_04020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
wYak_04030	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
wYak_04040	COG0792	nuclease activity
wYak_04060	COG0202	RNA polymerase activity
wYak_04070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
wYak_04080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
wYak_04090	COG0563	adenylate kinase activity
wYak_04100	COG0201	protein transport
wYak_04120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
wYak_04140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
wYak_04160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
wYak_04210	COG0255	Belongs to the universal ribosomal protein uL29 family
wYak_04230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
wYak_04260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
wYak_04270	COG0089	rRNA binding
wYak_04290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
wYak_04310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
wYak_04320	COG0505	Belongs to the CarA family
wYak_04350	COG1494	fructose-1,6-bisphosphatase
wYak_04370	COG0574	Belongs to the PEP-utilizing enzyme family
wYak_04370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
wYak_04430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
wYak_04460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
wYak_04480	COG1104	cysteine desulfurase activity
wYak_04490	COG2945	thiolester hydrolase activity
wYak_04520	COG0316	Belongs to the HesB IscA family
wYak_04530	COG0232	Belongs to the dGTPase family. Type 2 subfamily
wYak_04540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
wYak_04540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
wYak_04560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
wYak_04580	COG2171	N-acyltransferase activity
wYak_04630	COG0768	penicillin binding
wYak_04650	COG0606	chelatase, subunit chli
wYak_04710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
wYak_04740	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
wYak_04750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
wYak_04760	COG0745	RESPONSE REGULATOR receiver
wYak_04780	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
wYak_04790	COG0343	queuine tRNA-ribosyltransferase activity
wYak_04810	COG0612	Peptidase, M16
wYak_04820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
wYak_04830	COG1271	oxidase subunit
wYak_04840	COG1294	oxidase, subunit
wYak_04860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
wYak_04920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
wYak_04930	COG4974	Belongs to the 'phage' integrase family
wYak_04960	COG0450	alkyl hydroperoxide reductase
wYak_04990	COG0196	riboflavin kinase activity
wYak_05000	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
wYak_05010	COG0612	Peptidase, M16
wYak_05030	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
wYak_05100	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
wYak_05150	COG0629	single-stranded DNA binding
wYak_05160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
wYak_05170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
wYak_05180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
wYak_05200	COG0360	Binds together with S18 to 16S ribosomal RNA
wYak_05220	COG0359	binds to the 23S rRNA
wYak_05230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
wYak_05250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
wYak_05260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
wYak_05280	COG0473	3-isopropylmalate dehydrogenase activity
wYak_05310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
wYak_05350	COG0142	geranyltranstransferase activity
wYak_05360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
wYak_05390	COG3474	cytochrome
wYak_05440	COG0442	prolyl-tRNA aminoacylation
wYak_05450	COG0736	holo-[acyl-carrier-protein] synthase activity
wYak_05520	COG0009	L-threonylcarbamoyladenylate synthase
wYak_05540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
wYak_05560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
wYak_05630	COG0330	HflC and HflK could
wYak_05680	COG0556	nucleotide-excision repair
wYak_05710	COG4235	cytochrome complex assembly
wYak_05710	COG3088	subunit of a heme lyase
wYak_05740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
wYak_05770	COG0742	ribosomal rna small subunit methyltransferase
wYak_05800	COG3704	protein secretion by the type IV secretion system
wYak_05800	COG1340	protein secretion by the type IV secretion system
wYak_05810	COG3704	protein secretion by the type IV secretion system
wYak_05820	COG3704	protein secretion by the type IV secretion system
wYak_05830	COG3451	type IV secretory pathway VirB4
wYak_05850	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
wYak_05860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
wYak_05900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
wYak_05920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
wYak_05930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
wYak_05940	COG0254	rRNA binding
wYak_05950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
wYak_06020	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
wYak_06040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
wYak_06040	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
wYak_06070	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
wYak_06080	COG0552	protein localization to endoplasmic reticulum
wYak_06090	COG0822	iron-sulfur transferase activity
wYak_06100	COG0316	Belongs to the HesB IscA family
wYak_06110	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
wYak_06130	COG0681	Belongs to the peptidase S26 family
wYak_06150	COG1840	ABC-type Fe3 transport system, periplasmic component
wYak_06190	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
wYak_06210	COG1185	polyribonucleotide nucleotidyltransferase activity
wYak_06280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
wYak_06380	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
wYak_06400	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
wYak_06400	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
wYak_06400	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
wYak_06400	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
wYak_06410	COG1007	ATP synthesis coupled electron transport
wYak_06420	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
wYak_06430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
wYak_06440	COG0713	ATP synthesis coupled electron transport
wYak_06450	COG0839	Belongs to the complex I subunit 6 family
wYak_06500	COG0527	aspartate kinase activity
wYak_06520	COG0531	amino acid
wYak_06550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
wYak_06570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
wYak_06580	COG0670	Belongs to the BI1 family
wYak_06590	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
wYak_06660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
wYak_06670	COG1121	(ABC) transporter
wYak_06710	COG0267	Belongs to the bacterial ribosomal protein bL33 family
wYak_06720	COG1530	ribonuclease E activity
wYak_06730	COG0443	Heat shock 70 kDa protein
wYak_06750	COG0626	cystathionine gamma-synthase activity
wYak_06830	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
wYak_06840	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
wYak_06850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
wYak_06870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
wYak_06880	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
wYak_06890	COG0492	ferredoxin-NADP+ reductase activity
wYak_06900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
wYak_06920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
wYak_06930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
wYak_06940	COG1127	ABC transporter
wYak_06960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
wYak_06990	COG1104	cysteine desulfurase activity
wYak_07000	COG0312	modulator of DNA gyrase
wYak_07050	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
wYak_07050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
wYak_07110	COG0445	tRNA wobble uridine modification
wYak_07140	COG4695	Portal protein
wYak_07160	COG0321	lipoyl(octanoyl) transferase activity
wYak_07190	COG0047	phosphoribosylformylglycinamidine synthase activity
wYak_07230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
wYak_07240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
wYak_07270	COG1253	flavin adenine dinucleotide binding
wYak_07280	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
wYak_07290	COG0436	Aminotransferase
wYak_07340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
wYak_07390	COG1230	cation diffusion facilitator family transporter
wYak_07410	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
wYak_07420	COG1115	amino acid carrier protein
wYak_07430	COG1115	amino acid carrier protein
wYak_07440	COG1183	phosphatidylcholine synthase activity
wYak_07460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
wYak_07470	COG0484	heat shock protein binding
wYak_07480	COG0285	dihydrofolate synthase activity
wYak_07500	COG2867	negative regulation of translational initiation
wYak_07560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
wYak_07570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
wYak_07590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
wYak_07620	COG0101	tRNA pseudouridine synthase activity
wYak_07630	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
wYak_07630	COG2857	Cytochrome c1
wYak_07640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
wYak_07670	COG0484	heat shock protein binding
wYak_07690	COG0124	histidyl-tRNA synthetase
wYak_07710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
wYak_07730	COG0493	'glutamate synthase
wYak_07730	COG0543	2 iron, 2 sulfur cluster binding
wYak_07740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
wYak_07770	COG0750	zinc metalloprotease
wYak_07800	COG0776	regulation of translation
wYak_07810	COG0539	negative regulation of cytoplasmic translation
wYak_07820	COG0220	tRNA (guanine-N7-)-methyltransferase activity
wYak_07870	COG1160	GTP binding
wYak_07890	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
wYak_07900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
wYak_07910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
wYak_07950	COG0651	ATP synthesis coupled electron transport
wYak_07960	COG0772	Belongs to the SEDS family
wYak_07970	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
wYak_07980	COG2094	Belongs to the DNA glycosylase MPG family
wYak_08000	COG2255	four-way junction helicase activity
wYak_08010	COG0632	four-way junction helicase activity
wYak_08060	COG0494	nUDIX hydrolase
wYak_08070	COG0084	hydrolase, TatD family'
wYak_08090	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
wYak_08110	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
wYak_08160	COG1090	epimerase
wYak_08180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
wYak_08190	COG1054	Belongs to the UPF0176 family
wYak_08200	COG1178	ABC-type Fe3 transport system permease component
wYak_08240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
wYak_08250	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
wYak_08250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
wYak_08260	COG0628	permease
wYak_08290	COG4974	Belongs to the 'phage' integrase family
wYak_08310	COG0268	Binds directly to 16S ribosomal RNA
wYak_08320	COG0372	Belongs to the citrate synthase family
wYak_08350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
wYak_08360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
wYak_08370	COG0259	pyridoxamine-phosphate oxidase activity
wYak_08380	COG0658	competence protein
wYak_08380	COG2333	competence protein COMEC
wYak_08400	COG0564	pseudouridine synthase activity
wYak_08430	COG0126	phosphoglycerate kinase activity
wYak_08450	COG2070	2-Nitropropane dioxygenase
wYak_08480	COG3451	type IV secretory pathway VirB4
wYak_08530	COG0723	plastoquinol--plastocyanin reductase activity
wYak_08560	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
wYak_08570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
wYak_08590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
wYak_08600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
wYak_08610	COG0142	geranyltranstransferase activity
wYak_08630	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
wYak_08670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
wYak_08690	COG0105	UTP biosynthetic process
wYak_08700	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
wYak_08730	COG0508	dehydrogenase complex catalyzes the overall conversion of
wYak_08780	COG1268	BioY protein
wYak_08790	COG0778	Nitroreductase
wYak_08810	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
wYak_08820	COG0045	succinate-CoA ligase (ADP-forming) activity
wYak_08840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
wYak_08900	COG1475	DNA binding
wYak_08920	COG0653	protein targeting
wYak_09170	COG4804	nuclease activity
wYak_09220	COG2189	Belongs to the N(4) N(6)-methyltransferase family
wYak_09520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
wYak_09530	COG3621	Patatin-like phospholipase
wYak_09570	COG2003	Belongs to the UPF0758 family
wYak_09730	COG0666	response to abiotic stimulus
wYak_09750	COG2189	Belongs to the N(4) N(6)-methyltransferase family
wYak_10020	COG3621	Patatin-like phospholipase
wYak_10060	COG0649	NAD binding
wYak_10070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
wYak_10080	COG4536	flavin adenine dinucleotide binding
wYak_10090	COG3750	Belongs to the UPF0335 family
wYak_10100	COG0163	prenyltransferase activity
wYak_10110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
wYak_10160	COG0653	protein targeting
wYak_10180	COG0508	dehydrogenase complex catalyzes the overall conversion of
wYak_10200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
wYak_10380	COG1862	Preprotein translocase
wYak_10390	COG0052	Belongs to the universal ribosomal protein uS2 family
wYak_10400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
wYak_10410	COG0528	UMP kinase activity
wYak_10420	COG0233	cytoplasmic translational termination
wYak_10440	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
wYak_10450	COG0575	Belongs to the CDS family
wYak_10470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
wYak_10560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
wYak_10570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
wYak_10610	COG1132	(ABC) transporter
wYak_10660	COG0697	spore germination
wYak_10700	COG2003	Belongs to the UPF0758 family
wYak_10710	COG1396	sequence-specific DNA binding
wYak_10980	COG4804	nuclease activity
wYak_11030	COG2189	Belongs to the N(4) N(6)-methyltransferase family
wYak_11320	COG2009	succinate dehydrogenase
wYak_11330	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
wYak_11390	COG4591	ABC-type transport system involved in lipoprotein release permease component
wYak_11420	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
wYak_11430	COG0312	modulator of DNA gyrase
wYak_11440	COG1278	Cold shock
wYak_11450	COG0513	Belongs to the DEAD box helicase family
wYak_11470	COG1830	Aldolase
wYak_11480	COG0167	dihydroorotate dehydrogenase activity
wYak_11510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
wYak_11590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
wYak_11610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
wYak_11620	COG0037	tRNA processing
wYak_11630	COG2885	chlorophyll binding
wYak_11660	COG0482	sulfurtransferase activity
wYak_11680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
wYak_11690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
wYak_11700	COG0543	2 iron, 2 sulfur cluster binding
wYak_11700	COG0493	'glutamate synthase
wYak_11730	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
wYak_11760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
wYak_11770	COG0326	Molecular chaperone. Has ATPase activity
wYak_11790	COG0156	8-amino-7-oxononanoate synthase activity
wYak_11810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
wYak_11830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
wYak_11840	COG2202	Pas domain
wYak_11840	COG2205	protein histidine kinase activity
wYak_11850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
wYak_11860	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
wYak_11900	COG1295	ribonuclease BN
wYak_11910	COG1028	Short-chain dehydrogenase reductase Sdr
wYak_11920	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
wYak_11950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
wYak_11960	COG1006	Multisubunit Na H antiporter MnhC subunit
wYak_11980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
wYak_11980	COG2111	Na H antiporter
wYak_12030	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
wYak_12050	COG0567	Dehydrogenase, E1 component
wYak_12100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
wYak_12110	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
wYak_12120	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
wYak_12130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
wYak_12150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
wYak_12170	COG0174	glutamine synthetase