locus-tag	class	description
ASM33_00010	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
ASM33_00050	ENOG4108KQ5	Integrase catalytic subunit
ASM33_00055	ENOG4108ZX6	Electron transport protein SCO1 SenC
ASM33_00065	ENOG4105DHP	deoxycytidine triphosphate deaminase
ASM33_00095	ENOG4105C7I	Dehydrogenase
ASM33_00105	ENOG4105BZU	Histidine kinase
ASM33_00145	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ASM33_00165	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
ASM33_00170	ENOG4105C1V	Peptidase, M16
ASM33_00190	ENOG4105NWN	ApaG protein
ASM33_00220	ENOG4108JPZ	Monovalent cation H antiporter subunit D
ASM33_00245	ENOG4107QM5	aconitate hydratase
ASM33_00250	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
ASM33_00260	ENOG4107RZZ	dna polymerase iii epsilon subunit
ASM33_00275	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
ASM33_00290	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
ASM33_00295	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
ASM33_00300	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
ASM33_00315	ENOG4105C9Q	fumarate hydratase class II
ASM33_00335	ENOG4105VU5	Resolvase domain-containing protein
ASM33_00370	ENOG4108C33	Resolvase
ASM33_00405	ENOG4107XYW	BioY family
ASM33_00410	ENOG4105FG0	Nitroreductase
ASM33_00445	ENOG4105D5Q	Arginine ornithine antiporter
ASM33_00585	ENOG4105N82	Endonuclease
ASM33_00640	ENOG4105VU5	Resolvase domain-containing protein
ASM33_00655	ENOG4105W5Q	DNA repair protein (RadC
ASM33_00675	ENOG4105VU5	Resolvase domain-containing protein
ASM33_00725	ENOG4105C5W	Aldolase
ASM33_00735	ENOG4108JJ7	ABC transporter
ASM33_00765	ENOG4108KQ5	Integrase catalytic subunit
ASM33_00790	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
ASM33_00820	ENOG4105C0D	helicase
ASM33_00855	ENOG4105W5Q	DNA repair protein (RadC
ASM33_00865	ENOG4108WRK	Transcriptional regulator
ASM33_00890	ENOG4108WRK	Transcriptional regulator
ASM33_00900	ENOG4105K46	50S ribosomal protein l27
ASM33_00930	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
ASM33_00945	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
ASM33_00950	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ASM33_00960	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
ASM33_00965	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
ASM33_00980	ENOG4107UWY	Methyltransferase
ASM33_00985	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
ASM33_00995	ENOG4106WCW	Major outer membrane protein
ASM33_01005	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
ASM33_01015	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
ASM33_01020	ENOG4105DHJ	ABC, transporter
ASM33_01025	ENOG4105CY3	ABC transporter, permease
ASM33_01030	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
ASM33_01035	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
ASM33_01050	ENOG4105CJW	magnesium transporter
ASM33_01065	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
ASM33_01070	ENOG4105BZG	amino acid carrier protein
ASM33_01075	ENOG4105BZG	amino acid carrier protein
ASM33_01085	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
ASM33_01095	ENOG4105PGM	cation diffusion facilitator family transporter
ASM33_01105	ENOG4105W5Q	DNA repair protein (RadC
ASM33_01110	ENOG4107QKW	extracellular solute-binding protein family 1
ASM33_01130	ENOG4108KQ5	Integrase catalytic subunit
ASM33_01140	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
ASM33_01145	ENOG41082FS	50S ribosomal protein L31
ASM33_01150	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
ASM33_01155	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
ASM33_01230	ENOG4108MDK	Dehydrogenase
ASM33_01235	ENOG4108KQ5	Integrase catalytic subunit
ASM33_01245	ENOG4105CJN	penicillin-binding protein
ASM33_01255	ENOG4108KQ5	Integrase catalytic subunit
ASM33_01260	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
ASM33_01265	ENOG4105FDK	ABC transporter
ASM33_01270	ENOG4105NXV	High-affinity zinc uptake system protein
ASM33_01285	ENOG41060IM	Heme exporter protein
ASM33_01295	ENOG4108EHY	type IV secretion system
ASM33_01310	ENOG4105PDG	Type IV secretion system protein VirB8
ASM33_01315	ENOG4107QJN	gtp cyclohydrolase ii
ASM33_01350	ENOG4108KQ5	Integrase catalytic subunit
ASM33_01365	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
ASM33_01375	ENOG4105CPF	Cell wall formation (By similarity)
ASM33_01410	ENOG4106HA5	Protein of unknown function (DUF2497) 
ASM33_01415	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
ASM33_01450	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
ASM33_01480	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
ASM33_01500	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
ASM33_01505	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
ASM33_01510	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
ASM33_01515	ENOG41082FP	UPF0102 protein
ASM33_01520	ENOG4108ZT0	50S ribosomal protein l17
ASM33_01525	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
ASM33_01535	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ASM33_01545	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
ASM33_01550	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
ASM33_01555	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
ASM33_01560	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
ASM33_01565	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
ASM33_01570	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
ASM33_01575	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
ASM33_01580	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ASM33_01585	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
ASM33_01590	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
ASM33_01595	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
ASM33_01605	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
ASM33_01610	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
ASM33_01615	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
ASM33_01620	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
ASM33_01625	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ASM33_01630	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
ASM33_01640	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
ASM33_01650	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
ASM33_01665	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
ASM33_01680	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
ASM33_01685	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
ASM33_01690	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
ASM33_01695	ENOG4105C8U	phosphate abc transporter
ASM33_01700	ENOG41084M4	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
ASM33_01715	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
ASM33_01730	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
ASM33_01780	ENOG4105K63	Thioredoxin
ASM33_01800	ENOG4105EE5	Membrane protein terC
ASM33_01805	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
ASM33_01810	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
ASM33_01815	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
ASM33_01835	ENOG4105DZP	Membrane-associated zinc metalloprotease
ASM33_01840	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASM33_01850	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
ASM33_01860	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
ASM33_01875	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
ASM33_01880	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
ASM33_01885	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
ASM33_01895	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
ASM33_01975	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ASM33_01980	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
ASM33_01985	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
ASM33_02045	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
ASM33_02055	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
ASM33_02060	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
ASM33_02065	ENOG4108VZM	50s ribosomal protein L10
ASM33_02070	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
ASM33_02075	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
ASM33_02090	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
ASM33_02095	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
ASM33_02100	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
ASM33_02115	ENOG4105BZG	amino acid carrier protein
ASM33_02130	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
ASM33_02140	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
ASM33_02145	ENOG4105CPW	cytochrome b561
ASM33_02150	ENOG4105EA8	2-Nitropropane dioxygenase
ASM33_02165	ENOG4105W0E	50S ribosomal protein L33
ASM33_02170	ENOG4105C03	ribonuclease
ASM33_02190	ENOG4105CB5	ATP-dependent DNA helicase recG
ASM33_02195	ENOG4108Z03	MAF-like protein
ASM33_02215	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
ASM33_02250	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
ASM33_02270	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ASM33_02275	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
ASM33_02285	ENOG4105KCK	Peptidoglycan-associated lipoprotein
ASM33_02310	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
ASM33_02315	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
ASM33_02320	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
ASM33_02335	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
ASM33_02340	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
ASM33_02360	ENOG4108KQ5	Integrase catalytic subunit
ASM33_02365	ENOG4105C8Y	Acetylornithine aminotransferase
ASM33_02370	ENOG4105BZU	Histidine kinase
ASM33_02395	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
ASM33_02400	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
ASM33_02410	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
ASM33_02445	ENOG4108KQ5	Integrase catalytic subunit
ASM33_02500	ENOG4105WJX	transcriptional regulator MERR family
ASM33_02505	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
ASM33_02520	ENOG4105C9M	aspartyl-trna synthetase
ASM33_02525	ENOG4108KQ5	Integrase catalytic subunit
ASM33_02555	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
ASM33_02565	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
ASM33_02585	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
ASM33_02600	ENOG4108JJ6	Type I secretion system ATPase
ASM33_02615	ENOG4105CK2	sodium dicarboxylate symporter
ASM33_02620	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
ASM33_02630	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
ASM33_02635	ENOG4107QPR	SAICAR synthetase
ASM33_02645	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
ASM33_02655	ENOG4105E2Z	phosphate ABC transporter (Permease
ASM33_02660	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
ASM33_02695	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
ASM33_02700	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
ASM33_02705	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
ASM33_02725	ENOG4108KQ5	Integrase catalytic subunit
ASM33_02740	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
ASM33_02755	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
ASM33_02765	ENOG4105C2C	drug resistance transporter, Bcr CflA
ASM33_02775	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
ASM33_02835	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
ASM33_02845	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
ASM33_02855	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
ASM33_02865	ENOG4108VX5	3-methyladenine DNA glycosylase
ASM33_02880	ENOG4105DTN	riboflavin biosynthesis protein ribF
ASM33_02885	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
ASM33_02890	ENOG4105C1V	Peptidase, M16
ASM33_02900	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
ASM33_02915	ENOG4105DHZ	alpha beta
ASM33_02920	ENOG4107QI6	Cysteine desulfurase
ASM33_02940	ENOG4105HFZ	Membrane
ASM33_02945	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
ASM33_02950	ENOG4108JU6	CBS domain protein
ASM33_02955	ENOG4105Y2X	UPF0335 protein
ASM33_02960	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
ASM33_02965	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
ASM33_02995	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
ASM33_03000	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
ASM33_03010	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
ASM33_03020	ENOG41082WC	Transport-associated protein
ASM33_03025	ENOG4105D7Z	glutathione synthase
ASM33_03040	ENOG4105CSH	Transporter
ASM33_03060	ENOG4105CJR	Integral membrane protein (MviN
ASM33_03085	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
ASM33_03090	ENOG4108KQ5	Integrase catalytic subunit
ASM33_03095	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
ASM33_03115	ENOG4108KQ5	Integrase catalytic subunit
ASM33_03135	ENOG4105MJ2	Competence protein
ASM33_03145	ENOG4105C28	cystathionine
ASM33_03150	ENOG4105M85	Bola protein
ASM33_03170	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
ASM33_03185	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
ASM33_03215	ENOG4105EIN	peptidylprolyl cis-trans isomerase
ASM33_03220	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
ASM33_03265	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
ASM33_03275	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
ASM33_03295	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
ASM33_03300	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ASM33_03310	ENOG4105C22	threonyL-tRNA synthetase
ASM33_03315	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
ASM33_03345	ENOG4108VQJ	O-methyltransferase
ASM33_03365	ENOG4107QMP	dna polymerase iii subunits gamma and tau
ASM33_03390	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
ASM33_03395	ENOG4108KQ5	Integrase catalytic subunit
ASM33_03400	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
ASM33_03405	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
ASM33_03435	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
ASM33_03460	ENOG4105DA4	cytochrome c-type biogenesis protein
ASM33_03470	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
ASM33_03480	ENOG4105F0N	pyrophosphate phospho-hydrolase
ASM33_03495	ENOG4105CNI	cell division protein FtsW
ASM33_03515	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
ASM33_03525	ENOG4108KQ5	Integrase catalytic subunit
ASM33_03550	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
ASM33_03565	ENOG4105F8V	Hydrolase, tatD family
ASM33_03590	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
ASM33_03610	ENOG4106H78	methyltransferase
ASM33_03625	ENOG4106Q4M	protein secretion by the type IV secretion system
ASM33_03665	ENOG4105C3F	Signal peptidase i
ASM33_03680	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
ASM33_03690	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
ASM33_03695	ENOG4105D52	delta-aminolevulinic acid dehydratase
ASM33_03705	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
ASM33_03745	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
ASM33_03755	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
ASM33_03765	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
ASM33_03780	ENOG4105EIX	cytochrome c1
ASM33_03785	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
ASM33_03790	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
ASM33_03810	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
ASM33_03825	ENOG4105FAV	ABC, transporter
ASM33_03845	ENOG41080IJ	Diacylglycerol kinase
ASM33_03880	ENOG4105CDY	transcriptional regulatory protein
ASM33_03900	ENOG4105KDC	50s ribosomal protein l28
ASM33_03915	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
ASM33_03920	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
ASM33_03925	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
ASM33_03945	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
ASM33_03970	ENOG4105C6K	Malic enzyme
ASM33_03975	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
ASM33_03995	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASM33_04000	ENOG4105E33	succinate dehydrogenase
ASM33_04015	ENOG4108ZAI	phosphatidylglycerophosphatase a
ASM33_04035	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
ASM33_04045	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
ASM33_04070	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
ASM33_04085	ENOG4108J01	L-aspartate oxidase
ASM33_04095	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
ASM33_04100	ENOG4105DJV	ribulose-phosphate 3-epimerase
ASM33_04120	ENOG4105BZN	citrate synthase
ASM33_04140	ENOG41083G8	Multidrug resistance protein MdtM
ASM33_04160	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
ASM33_04170	ENOG4105KNE	Phosphatidate cytidylyltransferase
ASM33_04175	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
ASM33_04180	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
ASM33_04185	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
ASM33_04195	ENOG4105CE9	30S ribosomal protein S2
ASM33_04220	ENOG4105ECP	epimerase
ASM33_04230	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
ASM33_04285	ENOG4107QJR	hflk protein
ASM33_04315	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
ASM33_04320	ENOG4105C8T	Leucyl-tRNA synthetase
ASM33_04330	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
ASM33_04335	ENOG4105MKQ	Monovalent cation H antiporter subunit C
ASM33_04355	ENOG41067UH	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
ASM33_04380	ENOG4105DFU	Cell wall formation (By similarity)
ASM33_04400	ENOG4108KQ5	Integrase catalytic subunit
ASM33_04405	ENOG4105KWW	Biogenesis protein
ASM33_04420	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
ASM33_04435	ENOG4108R6K	riboflavin synthase, subunit alpha
ASM33_04450	ENOG4105ETU	transcriptional activator (TenA
ASM33_04455	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
ASM33_04465	ENOG4105G9V	cytochrome C
ASM33_04475	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
ASM33_04505	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
ASM33_04520	ENOG4107QX3	carboxylase
ASM33_04525	ENOG4108CAA	50S ribosomal protein L32
ASM33_04535	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
ASM33_04545	ENOG4105EMU	Dehydrogenase
ASM33_04550	ENOG4107U9T	Pfam:Ribonuclease_BN
ASM33_04555	ENOG4105DC1	bifunctional purine biosynthesis protein purh
ASM33_04570	ENOG4108KQ5	Integrase catalytic subunit
ASM33_04595	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
ASM33_04600	ENOG4108Z4V	iron-sulfur cluster assembly
ASM33_04605	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
ASM33_04615	ENOG4105C0B	DNA polymerase III (alpha subunit)
ASM33_04620	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
ASM33_04625	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
ASM33_04630	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
ASM33_04635	ENOG4105C83	adenylosuccinate lyase
ASM33_04650	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
ASM33_04670	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ASM33_04685	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ASM33_04695	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
ASM33_04735	ENOG4108Z4U	Ferredoxin
ASM33_04740	ENOG4105C79	DNA protecting protein DprA
ASM33_04745	ENOG4105DC7	peptidase M24
ASM33_04755	ENOG4105CDU	Replicative dna helicase
ASM33_04785	ENOG4105D5G	Transposase
ASM33_04805	ENOG4108C33	Resolvase
ASM33_04955	ENOG4105EKQ	RNA-directed DNA polymerase
ASM33_04960	ENOG4105VU5	Resolvase domain-containing protein
ASM33_05120	ENOG4108WRK	Transcriptional regulator
ASM33_05130	ENOG4105W5Q	DNA repair protein (RadC
ASM33_05175	ENOG4105W5Q	DNA repair protein (RadC
ASM33_05180	ENOG4105EQR	Transposase IS116 IS110 IS902
ASM33_05230	ENOG4105N82	Endonuclease
ASM33_05395	ENOG4105CEC	DNA methylase N-4 N-6
ASM33_05420	ENOG4105DFS	Conserved Protein
ASM33_05485	ENOG4105EQR	Transposase IS116 IS110 IS902
ASM33_05515	ENOG4108C33	Resolvase
ASM33_05520	ENOG4108WRK	Transcriptional regulator
ASM33_05525	ENOG4107R3N	Filamentation induced by cAMP protein fic
ASM33_05545	ENOG4107SNB	ankyrin repeat protein YahD
ASM33_05570	ENOG4105W5Q	DNA repair protein (RadC
ASM33_05585	ENOG4105VU5	Resolvase domain-containing protein
ASM33_05685	ENOG4105N82	Endonuclease
ASM33_05725	ENOG4107XZX	Involved in the transcription termination process (By similarity)
ASM33_05730	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
ASM33_05735	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
ASM33_05740	ENOG4108WIW	Aspartyl protease
ASM33_05775	ENOG4105CXT	aspartate transcarbamylase
ASM33_05795	ENOG4105D3R	alkyl hydroperoxide reductase
ASM33_05845	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
ASM33_05855	ENOG4105BZS	acriflavin resistance protein
ASM33_05870	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
ASM33_05885	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
ASM33_05890	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
ASM33_05920	ENOG4105CAY	ferredoxin--nadp reductase
ASM33_05945	ENOG4107QIZ	NADH dehydrogenase
ASM33_05980	ENOG4105EIE	fructose-bisphosphate aldolase
ASM33_05990	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
ASM33_05995	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ASM33_06000	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ASM33_06005	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ASM33_06010	ENOG4105K59	histidine triad (HIT) protein
ASM33_06025	ENOG4105CAS	nag kinase
ASM33_06030	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
ASM33_06035	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
ASM33_06045	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
ASM33_06060	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
ASM33_06080	ENOG4108KQ5	Integrase catalytic subunit
ASM33_06100	ENOG4105VF7	tolerance protein
ASM33_06110	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
ASM33_06115	ENOG4105CSH	Transporter
ASM33_06120	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
ASM33_06125	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
ASM33_06135	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
ASM33_06140	ENOG4105CSH	Transporter
ASM33_06160	ENOG4105C72	UPF0176 protein
ASM33_06165	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
ASM33_06170	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
ASM33_06175	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
ASM33_06185	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
ASM33_06195	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
ASM33_06205	ENOG4105WVQ	Fe-S assembly protein IscX
ASM33_06235	ENOG4105C3G	gtp-binding protein
ASM33_06260	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
ASM33_06275	ENOG4105CBT	Fructose-1,6-bisphosphatase
ASM33_06295	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
ASM33_06310	ENOG4108KQ5	Integrase catalytic subunit
ASM33_06345	ENOG4105BZA	Phosphoglycerate kinase
ASM33_06355	ENOG4105C7S	Dehydrogenase
ASM33_06370	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
ASM33_06380	ENOG4105CPP	Dehydrogenase, E1 component
ASM33_06405	ENOG4105C8N	cysteinyl-tRNA synthetase
ASM33_06410	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
ASM33_06440	ENOG41085Y2	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
ASM33_06445	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
ASM33_06500	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
ASM33_06515	ENOG4105C2M	dna polymerase I
ASM33_06530	ENOG4105FA0	parb-like partition protein
ASM33_06535	ENOG4107QJE	Chromosome Partitioning Protein
ASM33_06555	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
ASM33_06560	ENOG4107QN2	dihydrolipoyl dehydrogenase
ASM33_06580	ENOG4108JYK	Dehydrogenase
ASM33_06585	ENOG4108YXA	Membrane
ASM33_06610	ENOG4105K5M	30s ribosomal protein S16
ASM33_06615	ENOG4105EAH	synthase
ASM33_06620	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ASM33_06625	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
ASM33_06635	ENOG4105EI2	Pseudouridine synthase
ASM33_06660	ENOG4105C75	arginyL-tRNA synthetase
ASM33_06675	ENOG4105C8Y	Acetylornithine aminotransferase
ASM33_06690	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
ASM33_06700	ENOG4108KQ5	Integrase catalytic subunit
ASM33_06705	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
ASM33_06710	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
ASM33_06715	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
ASM33_06730	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
ASM33_06740	ENOG4108Z6B	deaminase
ASM33_06745	ENOG4105CFH	Aspartokinase
ASM33_06750	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
ASM33_06805	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
ASM33_06815	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
ASM33_06875	ENOG4105DZ1	carboxypeptidase
ASM33_06880	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
ASM33_06900	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
ASM33_06910	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
ASM33_06945	ENOG4105EFC	phage portal protein HK97 family
ASM33_06955	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
ASM33_06965	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
ASM33_06985	ENOG41082BR	50S ribosomal protein L35
ASM33_07040	ENOG4105D60	lipoprotein releasing system transmembrane protein
ASM33_07075	ENOG4105VU5	Resolvase domain-containing protein
ASM33_07090	ENOG4105W5Q	DNA repair protein (RadC
ASM33_07120	ENOG4105D5G	Transposase
ASM33_07140	ENOG4108C33	Resolvase
ASM33_07245	ENOG4105CEC	DNA methylase N-4 N-6
ASM33_07300	ENOG4105VU5	Resolvase domain-containing protein
ASM33_07395	ENOG4105CEC	DNA methylase N-4 N-6
ASM33_07555	ENOG4105N82	Endonuclease
ASM33_07580	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
ASM33_07605	ENOG4105VU5	Resolvase domain-containing protein
ASM33_07620	ENOG4105W5Q	DNA repair protein (RadC
ASM33_07645	ENOG4105VU5	Resolvase domain-containing protein
ASM33_07700	ENOG4105CUT	histidyl-tRNA synthetase
ASM33_07710	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
ASM33_07715	ENOG4105T40	surface antigen msp4 family protein
ASM33_07730	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
ASM33_07735	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
ASM33_07775	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
ASM33_07810	ENOG41072GX	Peptidase M22 Glycoprotease
ASM33_07835	ENOG4105BZ1	(ABC) transporter
ASM33_07880	ENOG4105CP7	Triose-phosphate isomerase
ASM33_07890	ENOG4105BZ1	(ABC) transporter
ASM33_07895	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
ASM33_07900	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
ASM33_07905	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
ASM33_07930	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
ASM33_07945	ENOG4105C3J	Cysteine desulfurase
ASM33_07970	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
ASM33_07990	ENOG4108KQ5	Integrase catalytic subunit
ASM33_07995	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
ASM33_08020	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
ASM33_08035	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
ASM33_08070	ENOG4105C1J	atp-dependent rna helicase
ASM33_08080	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
ASM33_08085	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
ASM33_08110	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
ASM33_08120	ENOG4105CI3	gtp-binding protein typa
ASM33_08130	ENOG4107QKV	phosphomannomutase
ASM33_08135	ENOG4105C02	permease
ASM33_08145	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
ASM33_08170	ENOG4105VG0	50S ribosomal protein l34
ASM33_08385	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase