locus-tag	class	description
MC061_00020	COG0505	Belongs to the CarA family
MC061_00025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MC061_00030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MC061_00040	COG0573	inorganic phosphate transmembrane transporter activity
MC061_00045	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MC061_00050	COG0594	ribonuclease P activity
MC061_00065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MC061_00065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MC061_00070	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MC061_00080	COG1845	cytochrome c oxidase, subunit III
MC061_00085	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MC061_00095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MC061_00100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MC061_00105	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MC061_00110	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MC061_00130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MC061_00135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC061_00140	COG0305	Participates in initiation and elongation during chromosome replication
MC061_00150	COG0477	Major facilitator Superfamily
MC061_00155	COG0590	tRNA wobble adenosine to inosine editing
MC061_00160	COG0504	CTP synthase activity
MC061_00200	COG0148	phosphopyruvate hydratase activity
MC061_00205	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MC061_00215	COG0321	lipoyl(octanoyl) transferase activity
MC061_00220	COG0047	phosphoribosylformylglycinamidine synthase activity
MC061_00225	COG0581	inorganic phosphate transmembrane transporter activity
MC061_00240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MC061_00245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MC061_00255	COG0436	Aminotransferase
MC061_00275	COG0445	tRNA wobble uridine modification
MC061_00285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MC061_00290	COG0416	fatty acid biosynthetic process
MC061_00295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MC061_00300	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MC061_00305	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MC061_00305	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MC061_00310	COG1007	ATP synthesis coupled electron transport
MC061_00315	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC061_00320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MC061_00325	COG0713	ATP synthesis coupled electron transport
MC061_00335	COG0210	DNA helicase
MC061_00355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MC061_00360	COG0649	NAD binding
MC061_00365	COG0629	single-stranded DNA binding
MC061_00380	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
MC061_00385	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
MC061_00405	COG0114	fumarate hydratase activity
MC061_00410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MC061_00415	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MC061_00430	COG0149	triose-phosphate isomerase activity
MC061_00435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MC061_00440	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MC061_00445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MC061_00450	COG0756	dUTP diphosphatase activity
MC061_00455	COG0567	Dehydrogenase, E1 component
MC061_00460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MC061_00465	COG0612	Peptidase, M16
MC061_00470	COG0539	negative regulation of cytoplasmic translation
MC061_00480	COG0750	zinc metalloprotease
MC061_00485	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MC061_00495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MC061_00500	COG0493	'glutamate synthase
MC061_00500	COG0543	2 iron, 2 sulfur cluster binding
MC061_00510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MC061_00520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MC061_00525	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MC061_00545	COG0450	alkyl hydroperoxide reductase
MC061_00550	COG0492	ferredoxin-NADP+ reductase activity
MC061_00600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MC061_00605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MC061_00625	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MC061_00635	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MC061_00635	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MC061_00650	COG0493	'glutamate synthase
MC061_00650	COG0543	2 iron, 2 sulfur cluster binding
MC061_00655	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MC061_00660	COG0326	Molecular chaperone. Has ATPase activity
MC061_00665	COG0156	8-amino-7-oxononanoate synthase activity
MC061_00685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MC061_00710	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MC061_00720	COG0280	phosphate acetyltransferase
MC061_00720	COG0281	malic enzyme
MC061_00725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MC061_00735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MC061_00755	COG0105	UTP biosynthetic process
MC061_00760	COG0312	modulator of DNA gyrase
MC061_00780	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MC061_00785	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MC061_00790	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC061_00795	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MC061_00805	COG1028	Short-chain dehydrogenase reductase Sdr
MC061_00820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MC061_00845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MC061_00850	COG1104	cysteine desulfurase activity
MC061_00855	COG1104	cysteine desulfurase activity
MC061_00860	COG2945	thiolester hydrolase activity
MC061_00865	COG0316	Belongs to the HesB IscA family
MC061_00870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MC061_00880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MC061_00890	COG0537	adenosine 5'-monophosphoramidase activity
MC061_00895	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC061_00905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC061_00915	COG0084	hydrolase, TatD family'
MC061_00920	COG0799	negative regulation of ribosome biogenesis
MC061_00925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MC061_00930	COG0632	four-way junction helicase activity
MC061_00940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MC061_00945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MC061_00960	COG0101	tRNA pseudouridine synthase activity
MC061_00975	COG1183	phosphatidylcholine synthase activity
MC061_00980	COG1115	amino acid carrier protein
MC061_00985	COG1115	amino acid carrier protein
MC061_00990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MC061_00995	COG1230	cation diffusion facilitator family transporter
MC061_01015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MC061_01025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MC061_01040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MC061_01045	COG0592	DNA-directed DNA polymerase activity
MC061_01050	COG0552	protein localization to endoplasmic reticulum
MC061_01055	COG0822	iron-sulfur transferase activity
MC061_01060	COG0316	Belongs to the HesB IscA family
MC061_01065	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MC061_01070	COG0443	Heat shock 70 kDa protein
MC061_01075	COG0681	Belongs to the peptidase S26 family
MC061_01080	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MC061_01090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MC061_01095	COG0196	riboflavin kinase activity
MC061_01100	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MC061_01105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MC061_01110	COG1054	Belongs to the UPF0176 family
MC061_01120	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MC061_01130	COG0531	amino acid
MC061_01135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MC061_01145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MC061_01160	COG0544	peptidyl-prolyl cis-trans isomerase activity
MC061_01165	COG0740	serine-type endopeptidase activity
MC061_01170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MC061_01175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MC061_01180	COG0126	phosphoglycerate kinase activity
MC061_01190	COG0194	GDP metabolic process
MC061_01195	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MC061_01205	COG0508	dehydrogenase complex catalyzes the overall conversion of
MC061_01220	COG3932	Exopolysaccharide synthesis, ExoD
MC061_01225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MC061_01235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MC061_01240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MC061_01245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC061_01245	COG0072	phenylalanine-tRNA ligase activity
MC061_01250	COG0356	it plays a direct role in the translocation of protons across the membrane
MC061_01255	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MC061_01260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MC061_01280	COG2239	Acts as a magnesium transporter
MC061_01290	COG0574	Belongs to the PEP-utilizing enzyme family
MC061_01290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MC061_01295	COG1494	fructose-1,6-bisphosphatase
MC061_01300	COG0012	GTP binding
MC061_01305	COG0617	tRNA 3'-terminal CCA addition
MC061_01310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MC061_01330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MC061_01340	COG0187	DNA topoisomerase II activity
MC061_01345	COG0154	amidase activity
MC061_01350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MC061_01370	COG0343	queuine tRNA-ribosyltransferase activity
MC061_01375	COG0228	four-way junction DNA binding
MC061_01380	COG0142	geranyltranstransferase activity
MC061_01395	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MC061_01405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MC061_01430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MC061_01430	COG2890	protein-(glutamine-N5) methyltransferase activity
MC061_01435	COG1138	Cytochrome C-type biogenesis protein
MC061_01445	COG0706	membrane insertase activity
MC061_01460	COG0424	maF-like protein
MC061_01465	COG1115	amino acid carrier protein
MC061_01470	COG0459	protein refolding
MC061_01480	COG0354	folic acid binding
MC061_01485	COG1053	succinate dehydrogenase
MC061_01490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MC061_01500	COG0237	dephospho-CoA kinase activity
MC061_01505	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MC061_01510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MC061_01525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MC061_01530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MC061_01550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MC061_01555	COG0081	regulation of translation
MC061_01560	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MC061_01565	COG0222	ribosome binding
MC061_01570	COG0085	RNA polymerase activity
MC061_01570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MC061_01575	COG0275	rRNA processing
MC061_01580	COG0024	Methionine aminopeptidase
MC061_01585	COG0242	peptide deformylase activity
MC061_01590	COG1573	uracil-dna glycosylase
MC061_01595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MC061_01600	COG4536	flavin adenine dinucleotide binding
MC061_01605	COG0163	prenyltransferase activity
MC061_01615	COG0495	leucyl-tRNA aminoacylation
MC061_01625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MC061_01630	COG1830	Aldolase
MC061_01640	COG0167	dihydroorotate dehydrogenase activity
MC061_01650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MC061_01655	COG1006	Multisubunit Na H antiporter MnhC subunit
MC061_01685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MC061_01690	COG0508	dehydrogenase complex catalyzes the overall conversion of
MC061_01695	COG0653	protein targeting
MC061_01700	COG1322	Protein conserved in bacteria
MC061_01705	COG0284	orotidine-5'-phosphate decarboxylase activity
MC061_01710	COG0525	valine-tRNA ligase activity
MC061_01720	COG4770	biotin carboxylase activity
MC061_01725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MC061_01735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MC061_01740	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MC061_01745	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC061_01750	COG0470	DNA polymerase III
MC061_01755	COG0009	L-threonylcarbamoyladenylate synthase
MC061_01760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MC061_01765	COG0481	GTPase activity
MC061_01770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MC061_01780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MC061_01800	COG1121	(ABC) transporter
MC061_01805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MC061_01815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MC061_01820	COG0312	modulator of DNA gyrase
MC061_01825	COG1278	Cold shock
MC061_01830	COG0513	Belongs to the DEAD box helicase family
MC061_01835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MC061_01840	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MC061_01845	COG0045	succinate-CoA ligase (ADP-forming) activity
MC061_01860	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
MC061_01870	COG1160	GTP binding
MC061_01875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MC061_01890	COG0477	Major facilitator Superfamily
MC061_01905	COG0651	ATP synthesis coupled electron transport
MC061_01915	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MC061_01930	COG0492	ferredoxin-NADP+ reductase activity
MC061_01935	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MC061_01945	COG0752	glycyl-tRNA synthetase alpha subunit
MC061_01950	COG0751	glycine-tRNA ligase activity
MC061_01960	COG1034	ATP synthesis coupled electron transport
MC061_01965	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MC061_01970	COG0113	porphobilinogen synthase activity
MC061_01975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MC061_01980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MC061_01985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MC061_02005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MC061_02030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MC061_02040	COG1981	membrane
MC061_02045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MC061_02050	COG0564	pseudouridine synthase activity
MC061_02055	COG0018	arginyl-trna synthetase
MC061_02060	COG1132	(ABC) transporter
MC061_02070	COG2814	Major facilitator Superfamily
MC061_02080	COG2902	Dehydrogenase
MC061_02085	COG0542	response to heat
MC061_02090	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MC061_02095	COG0575	Belongs to the CDS family
MC061_02105	COG0528	UMP kinase activity
MC061_02115	COG0052	Belongs to the universal ribosomal protein uS2 family
MC061_02130	COG1999	signal sequence binding
MC061_02135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MC061_02145	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MC061_02155	COG0736	holo-[acyl-carrier-protein] synthase activity
MC061_02160	COG0442	prolyl-tRNA aminoacylation
MC061_02165	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MC061_02185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MC061_02190	COG0723	plastoquinol--plastocyanin reductase activity
MC061_02200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MC061_02210	COG1217	gtp-binding protein TYPA
MC061_02225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MC061_02240	COG1301	dicarboxylic acid transport
MC061_02245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MC061_02265	COG0484	heat shock protein binding
MC061_02280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MC061_02290	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
MC061_02300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MC061_02305	COG0330	HflC and HflK could
MC061_02325	COG0360	Binds together with S18 to 16S ribosomal RNA
MC061_02330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MC061_02335	COG0359	binds to the 23S rRNA
MC061_02340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MC061_02350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MC061_02355	COG1530	ribonuclease E activity
MC061_02375	COG0670	Belongs to the BI1 family
MC061_02380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MC061_02390	COG2009	succinate dehydrogenase
MC061_02410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MC061_02415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MC061_02420	COG0138	bifunctional purine biosynthesis protein purh
MC061_02430	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MC061_02435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MC061_02440	COG0254	rRNA binding
MC061_02450	COG0022	dehydrogenase e1 component
MC061_02450	COG0508	dehydrogenase complex catalyzes the overall conversion of
MC061_02455	COG0805	protein transport
MC061_02465	COG0328	RNA-DNA hybrid ribonuclease activity
MC061_02475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MC061_02480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MC061_02490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MC061_02495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MC061_02500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MC061_02515	COG0202	RNA polymerase activity
MC061_02520	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MC061_02525	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MC061_02530	COG0563	adenylate kinase activity
MC061_02535	COG0201	protein transport
MC061_02540	COG0200	Binds to the 23S rRNA
MC061_02545	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MC061_02550	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MC061_02565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MC061_02570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MC061_02575	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MC061_02600	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MC061_02615	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MC061_02620	COG0089	rRNA binding
MC061_02630	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit