locus-tag	class	description
M1L25_000001	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M1L25_000002	COG0436	Aminotransferase
M1L25_000006	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M1L25_000007	COG0126	phosphoglycerate kinase activity
M1L25_000010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1L25_000011	COG1185	polyribonucleotide nucleotidyltransferase activity
M1L25_000012	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M1L25_000013	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1L25_000015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1L25_000015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1L25_000016	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M1L25_000017	COG0316	Belongs to the HesB IscA family
M1L25_000019	COG2945	thiolester hydrolase activity
M1L25_000020	COG1104	cysteine desulfurase activity
M1L25_000021	COG0670	Belongs to the BI1 family
M1L25_000022	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M1L25_000026	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1L25_000027	COG0629	single-stranded DNA binding
M1L25_000032	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M1L25_000034	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
M1L25_000039	COG0493	'glutamate synthase
M1L25_000039	COG0543	2 iron, 2 sulfur cluster binding
M1L25_000040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1L25_000051	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1L25_000055	COG0326	Molecular chaperone. Has ATPase activity
M1L25_000064	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M1L25_000069	COG2003	Belongs to the UPF0758 family
M1L25_000070	COG1396	sequence-specific DNA binding
M1L25_000077	COG2003	Belongs to the UPF0758 family
M1L25_000083	COG0697	spore germination
M1L25_000088	COG1132	(ABC) transporter
M1L25_000092	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1L25_000093	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M1L25_000110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1L25_000111	COG0799	negative regulation of ribosome biogenesis
M1L25_000113	COG0494	nUDIX hydrolase
M1L25_000114	COG0084	hydrolase, TatD family'
M1L25_000115	COG0039	L-malate dehydrogenase activity
M1L25_000116	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1L25_000117	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1L25_000118	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1L25_000119	COG0537	adenosine 5'-monophosphoramidase activity
M1L25_000123	COG1090	epimerase
M1L25_000125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M1L25_000126	COG0416	fatty acid biosynthetic process
M1L25_000127	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M1L25_000128	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1L25_000129	COG1127	ABC transporter
M1L25_000130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1L25_000133	COG0493	'glutamate synthase
M1L25_000133	COG0543	2 iron, 2 sulfur cluster binding
M1L25_000134	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M1L25_000137	COG0750	zinc metalloprotease
M1L25_000140	COG0776	regulation of translation
M1L25_000141	COG0539	negative regulation of cytoplasmic translation
M1L25_000142	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1L25_000146	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1L25_000150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M1L25_000151	COG0259	pyridoxamine-phosphate oxidase activity
M1L25_000152	COG0047	phosphoribosylformylglycinamidine synthase activity
M1L25_000153	COG0581	inorganic phosphate transmembrane transporter activity
M1L25_000154	COG0335	large ribosomal subunit rRNA binding
M1L25_000155	COG0336	Belongs to the RNA methyltransferase TrmD family
M1L25_000156	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M1L25_000157	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M1L25_000161	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1L25_000164	COG2094	Belongs to the DNA glycosylase MPG family
M1L25_000166	COG0489	protein tyrosine kinase activity
M1L25_000174	COG0723	plastoquinol--plastocyanin reductase activity
M1L25_000176	COG0312	modulator of DNA gyrase
M1L25_000181	COG0285	dihydrofolate synthase activity
M1L25_000184	COG2867	negative regulation of translational initiation
M1L25_000191	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1L25_000192	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M1L25_000194	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M1L25_000197	COG0101	tRNA pseudouridine synthase activity
M1L25_000198	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M1L25_000200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M1L25_000202	COG0275	rRNA processing
M1L25_000204	COG0024	Methionine aminopeptidase
M1L25_000205	COG0849	cell division
M1L25_000206	COG0242	peptide deformylase activity
M1L25_000207	COG1573	uracil-dna glycosylase
M1L25_000208	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
M1L25_000210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M1L25_000212	COG1295	ribonuclease BN
M1L25_000213	COG1028	Short-chain dehydrogenase reductase Sdr
M1L25_000214	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M1L25_000215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M1L25_000216	COG0564	pseudouridine synthase activity
M1L25_000220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M1L25_000224	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M1L25_000225	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1L25_000227	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M1L25_000229	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1L25_000234	COG1758	RNA polymerase activity
M1L25_000236	COG1320	monovalent cation:proton antiporter activity
M1L25_000237	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1L25_000237	COG2111	Na H antiporter
M1L25_000239	COG1006	Multisubunit Na H antiporter MnhC subunit
M1L25_000240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M1L25_000245	COG2009	succinate dehydrogenase
M1L25_000246	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1L25_000249	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1L25_000252	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M1L25_000253	COG0312	modulator of DNA gyrase
M1L25_000254	COG1278	Cold shock
M1L25_000256	COG0542	response to heat
M1L25_000258	COG1830	Aldolase
M1L25_000260	COG0167	dihydroorotate dehydrogenase activity
M1L25_000261	COG0571	ribonuclease III activity
M1L25_000263	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1L25_000265	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M1L25_000266	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1L25_000269	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M1L25_000271	COG1034	ATP synthesis coupled electron transport
M1L25_000272	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M1L25_000273	COG0113	porphobilinogen synthase activity
M1L25_000275	COG0752	glycyl-tRNA synthetase alpha subunit
M1L25_000276	COG0751	glycine-tRNA ligase activity
M1L25_000277	COG0322	excinuclease ABC activity
M1L25_000279	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1L25_000283	COG1230	cation diffusion facilitator family transporter
M1L25_000285	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M1L25_000286	COG1115	amino acid carrier protein
M1L25_000287	COG1115	amino acid carrier protein
M1L25_000288	COG1183	phosphatidylcholine synthase activity
M1L25_000292	COG0187	DNA topoisomerase II activity
M1L25_000293	COG0154	amidase activity
M1L25_000294	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1L25_000294	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1L25_000300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1L25_000302	COG0307	riboflavin synthase, alpha
M1L25_000304	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M1L25_000305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M1L25_000310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M1L25_000311	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M1L25_000313	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M1L25_000314	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1L25_000316	COG1845	cytochrome c oxidase, subunit III
M1L25_000318	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1L25_000319	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1L25_000319	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1L25_000324	COG0594	ribonuclease P activity
M1L25_000325	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M1L25_000326	COG0573	inorganic phosphate transmembrane transporter activity
M1L25_000327	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M1L25_000328	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M1L25_000336	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M1L25_000337	COG0051	transcription antitermination factor activity, RNA binding
M1L25_000338	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M1L25_000339	COG0088	Forms part of the polypeptide exit tunnel
M1L25_000341	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M1L25_000342	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M1L25_000343	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M1L25_000344	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M1L25_000345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M1L25_000346	COG0255	Belongs to the universal ribosomal protein uL29 family
M1L25_000348	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M1L25_000349	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M1L25_000350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M1L25_000351	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M1L25_000352	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M1L25_000354	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M1L25_000355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M1L25_000356	COG0200	Binds to the 23S rRNA
M1L25_000357	COG0201	protein transport
M1L25_000358	COG0563	adenylate kinase activity
M1L25_000359	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M1L25_000360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M1L25_000361	COG0202	RNA polymerase activity
M1L25_000362	COG0203	ribosomal protein L17
M1L25_000363	COG0792	nuclease activity
M1L25_000364	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M1L25_000365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M1L25_000366	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1L25_000367	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1L25_000367	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1L25_000371	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1L25_000371	COG0574	Belongs to the PEP-utilizing enzyme family
M1L25_000376	COG0481	GTPase activity
M1L25_000379	COG0196	riboflavin kinase activity
M1L25_000380	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M1L25_000384	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M1L25_000386	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M1L25_000389	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M1L25_000393	COG1381	Involved in DNA repair and RecF pathway recombination
M1L25_000396	COG2902	Dehydrogenase
M1L25_000397	COG0542	response to heat
M1L25_000411	COG1396	sequence-specific DNA binding
M1L25_000412	COG2003	Belongs to the UPF0758 family
M1L25_000417	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1L25_000424	COG1181	Belongs to the D-alanine--D-alanine ligase family
M1L25_000426	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1L25_000430	COG1322	Protein conserved in bacteria
M1L25_000431	COG1686	Belongs to the peptidase S11 family
M1L25_000432	COG2003	Belongs to the UPF0758 family
M1L25_000434	COG1138	Cytochrome C-type biogenesis protein
M1L25_000438	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M1L25_000440	COG0477	Major facilitator Superfamily
M1L25_000441	COG0564	pseudouridine synthase activity
M1L25_000445	COG2239	Acts as a magnesium transporter
M1L25_000449	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M1L25_000450	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M1L25_000455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M1L25_000457	COG3577	Aspartyl protease
M1L25_000463	COG0756	dUTP diphosphatase activity
M1L25_000469	COG0736	holo-[acyl-carrier-protein] synthase activity
M1L25_000473	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M1L25_000477	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M1L25_000488	COG0666	response to abiotic stimulus
M1L25_000490	COG1494	fructose-1,6-bisphosphatase
M1L25_000494	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M1L25_000496	COG3932	Exopolysaccharide synthesis, ExoD
M1L25_000497	COG0215	cysteine-tRNA ligase activity
M1L25_000500	COG0109	protoheme IX farnesyltransferase activity
M1L25_000501	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1L25_000502	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1L25_000503	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1L25_000504	COG1981	membrane
M1L25_000505	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1L25_000506	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1L25_000507	COG4974	Belongs to the 'phage' integrase family
M1L25_000510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1L25_000512	COG0525	valine-tRNA ligase activity
M1L25_000516	COG0653	protein targeting
M1L25_000520	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M1L25_000525	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1L25_000528	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1L25_000529	COG0575	Belongs to the CDS family
M1L25_000531	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M1L25_000544	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1L25_000545	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M1L25_000549	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M1L25_000550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1L25_000554	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1L25_000555	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1L25_000556	COG0823	Involved in the tonB-independent uptake of proteins
M1L25_000558	COG0484	heat shock protein binding
M1L25_000561	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1L25_000562	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
M1L25_000564	COG0114	fumarate hydratase activity
M1L25_000570	COG3346	SURF1 family
M1L25_000573	COG0148	phosphopyruvate hydratase activity
M1L25_000574	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M1L25_000580	COG1674	ftsk spoiiie
M1L25_000583	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M1L25_000588	COG0235	Class ii aldolase
M1L25_000592	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1L25_000593	COG0358	DNA primase activity
M1L25_000597	COG3088	subunit of a heme lyase
M1L25_000598	COG1074	ATP-dependent DNA helicase activity
M1L25_000601	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1L25_000604	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1L25_000604	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
M1L25_000605	COG1217	gtp-binding protein TYPA
M1L25_000606	COG0617	tRNA 3'-terminal CCA addition
M1L25_000616	COG0012	GTP binding
M1L25_000622	COG0284	orotidine-5'-phosphate decarboxylase activity
M1L25_000627	COG0805	protein transport
M1L25_000631	COG0450	alkyl hydroperoxide reductase
M1L25_000634	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1L25_000635	COG1121	(ABC) transporter
M1L25_000638	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M1L25_000639	COG1530	ribonuclease E activity
M1L25_000640	COG0443	Heat shock 70 kDa protein
M1L25_000641	COG0271	Belongs to the BolA IbaG family
M1L25_000642	COG0626	cystathionine gamma-synthase activity
M1L25_000644	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M1L25_000646	COG0009	L-threonylcarbamoyladenylate synthase
M1L25_000647	COG0470	DNA polymerase III
M1L25_000651	COG0305	Participates in initiation and elongation during chromosome replication
M1L25_000653	COG1714	RDD family
M1L25_000656	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M1L25_000657	COG0237	dephospho-CoA kinase activity
M1L25_000660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1L25_000666	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1L25_000669	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M1L25_000670	COG0459	protein refolding
M1L25_000672	COG1115	amino acid carrier protein
M1L25_000674	COG0424	maF-like protein
M1L25_000677	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1L25_000679	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M1L25_000680	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M1L25_000681	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M1L25_000685	COG2814	Major facilitator Superfamily
M1L25_000687	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1L25_000689	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1L25_000694	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1L25_000699	COG0022	dehydrogenase e1 component
M1L25_000699	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1L25_000702	COG0681	Belongs to the peptidase S26 family
M1L25_000703	COG0443	Heat shock 70 kDa protein
M1L25_000705	COG0316	Belongs to the HesB IscA family
M1L25_000706	COG0822	iron-sulfur transferase activity
M1L25_000707	COG0552	protein localization to endoplasmic reticulum
M1L25_000708	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M1L25_000709	COG0477	Major facilitator Superfamily
M1L25_000710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M1L25_000713	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
M1L25_000716	COG3736	Type IV secretory pathway, component VirB8
M1L25_000721	COG0717	Belongs to the dCTP deaminase family
M1L25_000722	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1L25_000725	COG0233	cytoplasmic translational termination
M1L25_000726	COG0528	UMP kinase activity
M1L25_000727	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M1L25_000728	COG0052	Belongs to the universal ribosomal protein uS2 family
M1L25_000730	COG1862	Preprotein translocase
M1L25_000735	COG4451	ribulose bisphosphate carboxylase, small
M1L25_000735	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1L25_000737	COG0504	CTP synthase activity
M1L25_000739	COG0590	tRNA wobble adenosine to inosine editing
M1L25_000742	COG4133	protoheme IX ABC transporter activity
M1L25_000743	COG0018	arginyl-trna synthetase
M1L25_000747	COG1132	(ABC) transporter
M1L25_000748	COG2226	methyltransferase
M1L25_000749	COG2814	Major facilitator Superfamily
M1L25_000755	COG0739	heme binding
M1L25_000756	COG0217	transcriptional regulatory protein
M1L25_000759	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1L25_000760	COG0281	malic enzyme
M1L25_000760	COG0280	phosphate acetyltransferase
M1L25_000762	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1L25_000763	COG1566	PFAM secretion protein HlyD family protein
M1L25_000777	COG0544	peptidyl-prolyl cis-trans isomerase activity
M1L25_000778	COG0740	serine-type endopeptidase activity
M1L25_000779	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M1L25_000780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M1L25_000781	COG0768	penicillin binding
M1L25_000782	COG0726	polysaccharide deacetylase
M1L25_000783	COG0606	chelatase, subunit chli
M1L25_000788	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M1L25_000789	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1L25_000792	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1L25_000793	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M1L25_000794	COG0745	RESPONSE REGULATOR receiver
M1L25_000798	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M1L25_000799	COG0343	queuine tRNA-ribosyltransferase activity
M1L25_000801	COG0612	Peptidase, M16
M1L25_000802	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1L25_000805	COG0742	ribosomal rna small subunit methyltransferase
M1L25_000808	COG1340	protein secretion by the type IV secretion system
M1L25_000808	COG3704	protein secretion by the type IV secretion system
M1L25_000809	COG3704	protein secretion by the type IV secretion system
M1L25_000810	COG3704	protein secretion by the type IV secretion system
M1L25_000811	COG3451	type IV secretory pathway VirB4
M1L25_000813	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
M1L25_000819	COG1475	DNA binding
M1L25_000820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M1L25_000820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M1L25_000823	COG0628	permease
M1L25_000827	COG4974	Belongs to the 'phage' integrase family
M1L25_000829	COG0268	Binds directly to 16S ribosomal RNA
M1L25_000830	COG0372	Belongs to the citrate synthase family
M1L25_000833	COG2827	Endonuclease containing a URI domain
M1L25_000835	COG2255	four-way junction helicase activity
M1L25_000836	COG0632	four-way junction helicase activity
M1L25_000837	COG3474	cytochrome
M1L25_000841	COG0839	Belongs to the complex I subunit 6 family
M1L25_000842	COG0713	ATP synthesis coupled electron transport
M1L25_000843	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1L25_000844	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1L25_000845	COG1007	ATP synthesis coupled electron transport
M1L25_000846	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M1L25_000846	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M1L25_000847	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M1L25_000854	COG2003	Belongs to the UPF0758 family
M1L25_000865	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1L25_000875	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
M1L25_000877	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1L25_000877	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1L25_000885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1L25_000889	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1L25_000890	COG0359	binds to the 23S rRNA
M1L25_000892	COG0360	Binds together with S18 to 16S ribosomal RNA
M1L25_000898	COG0321	lipoyl(octanoyl) transferase activity
M1L25_000901	COG4695	Portal protein
M1L25_000905	COG0728	peptidoglycan biosynthetic process
M1L25_000908	COG0445	tRNA wobble uridine modification
M1L25_000909	COG0006	proline dipeptidase activity
M1L25_000918	COG3451	type IV secretory pathway VirB4
M1L25_000921	COG2070	2-Nitropropane dioxygenase
M1L25_000923	COG0649	NAD binding
M1L25_000924	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1L25_000925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1L25_000926	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1L25_000928	COG0072	phenylalanine-tRNA ligase activity
M1L25_000928	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1L25_000930	COG0356	it plays a direct role in the translocation of protons across the membrane
M1L25_000931	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M1L25_000934	COG1215	transferase activity, transferring glycosyl groups
M1L25_000935	COG1612	heme a metabolic process
M1L25_000936	COG4770	biotin carboxylase activity
M1L25_000938	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1L25_000939	COG0071	Belongs to the small heat shock protein (HSP20) family
M1L25_000940	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M1L25_000943	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M1L25_000945	COG3827	peptidoglycan binding
M1L25_000946	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M1L25_000951	COG1268	BioY protein
M1L25_000956	COG0045	succinate-CoA ligase (ADP-forming) activity
M1L25_000959	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1L25_000964	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M1L25_000967	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1L25_000968	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1L25_000969	COG0254	rRNA binding
M1L25_000972	COG1840	ABC-type Fe3 transport system, periplasmic component
M1L25_000973	COG0540	Belongs to the ATCase OTCase family
M1L25_000976	COG0194	GDP metabolic process
M1L25_000978	COG1053	succinate dehydrogenase
M1L25_000980	COG2171	N-acyltransferase activity
M1L25_000987	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M1L25_000988	COG0149	triose-phosphate isomerase activity
M1L25_000993	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M1L25_000996	COG3547	Transposase (IS116 IS110 IS902 family)
M1L25_000999	COG0473	3-isopropylmalate dehydrogenase activity
M1L25_001002	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M1L25_001005	COG0085	RNA polymerase activity
M1L25_001005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M1L25_001006	COG0222	ribosome binding
M1L25_001007	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M1L25_001008	COG0081	regulation of translation
M1L25_001009	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M1L25_001010	COG0250	Participates in transcription elongation, termination and antitermination
M1L25_001013	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M1L25_001014	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M1L25_001015	COG0049	tRNA binding
M1L25_001016	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M1L25_001017	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1L25_001017	COG2890	protein-(glutamine-N5) methyltransferase activity
M1L25_001019	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1L25_001021	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M1L25_001022	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M1L25_001028	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M1L25_001034	COG0567	Dehydrogenase, E1 component
M1L25_001037	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M1L25_001038	COG0142	geranyltranstransferase activity
M1L25_001039	COG0228	four-way junction DNA binding
M1L25_001040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1L25_001043	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1L25_001055	COG1054	Belongs to the UPF0176 family
M1L25_001056	COG1178	ABC-type Fe3 transport system permease component
M1L25_001058	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1L25_001059	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M1L25_001061	COG1113	amino acid transport
M1L25_001062	COG0531	amino acid
M1L25_001064	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M1L25_001065	COG0124	histidyl-tRNA synthetase
M1L25_001067	COG0484	heat shock protein binding
M1L25_001070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M1L25_001071	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M1L25_001071	COG2857	Cytochrome c1
M1L25_001072	COG0556	nucleotide-excision repair
M1L25_001074	COG0776	regulation of translation
M1L25_001077	COG0495	leucyl-tRNA aminoacylation
M1L25_001080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M1L25_001081	COG0163	prenyltransferase activity
M1L25_001082	COG3750	Belongs to the UPF0335 family
M1L25_001083	COG4536	flavin adenine dinucleotide binding
M1L25_001084	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1L25_001085	COG0105	UTP biosynthetic process
M1L25_001087	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M1L25_001090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M1L25_001091	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M1L25_001093	COG0142	geranyltranstransferase activity
M1L25_001094	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1L25_001095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1L25_001096	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1L25_001097	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M1L25_001101	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1L25_001103	COG0482	sulfurtransferase activity
M1L25_001106	COG2885	chlorophyll binding
M1L25_001108	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1L25_001111	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1L25_001115	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M1L25_001117	COG2205	protein histidine kinase activity
M1L25_001118	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1L25_001120	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1L25_001121	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M1L25_001123	COG0156	8-amino-7-oxononanoate synthase activity
M1L25_001133	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1L25_001137	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1L25_001140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1L25_001142	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M1L25_001143	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M1L25_001144	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M1L25_001146	COG1450	Type ii and iii secretion system protein
M1L25_001147	COG0519	Catalyzes the synthesis of GMP from XMP
M1L25_001147	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1L25_001148	COG1253	flavin adenine dinucleotide binding
M1L25_001152	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M1L25_001153	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M1L25_001154	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M1L25_001186	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1L25_001197	COG0330	HflC and HflK could
M1L25_001202	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1L25_001217	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1L25_001218	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M1L25_001219	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M1L25_001220	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1L25_001226	COG0492	ferredoxin-NADP+ reductase activity
M1L25_001230	COG1104	cysteine desulfurase activity
M1L25_001231	COG0772	Belongs to the SEDS family
M1L25_001232	COG0651	ATP synthesis coupled electron transport
M1L25_001239	COG1253	flavin adenine dinucleotide binding