locus-tag	class	description
JKF54_00010	COG0697	spore germination
JKF54_00015	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JKF54_00035	COG1132	(ABC) transporter
JKF54_00105	COG0542	response to heat
JKF54_00110	COG2902	Dehydrogenase
JKF54_00125	COG1381	Involved in DNA repair and RecF pathway recombination
JKF54_00335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JKF54_00350	COG1396	sequence-specific DNA binding
JKF54_00360	COG2003	Belongs to the UPF0758 family
JKF54_00365	COG1396	sequence-specific DNA binding
JKF54_00415	COG1181	Belongs to the D-alanine--D-alanine ligase family
JKF54_00430	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JKF54_00450	COG1322	Protein conserved in bacteria
JKF54_00455	COG1686	Belongs to the peptidase S11 family
JKF54_00460	COG2003	Belongs to the UPF0758 family
JKF54_00470	COG1138	Cytochrome C-type biogenesis protein
JKF54_00490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JKF54_00500	COG0477	Major facilitator Superfamily
JKF54_00505	COG0564	pseudouridine synthase activity
JKF54_00525	COG2239	Acts as a magnesium transporter
JKF54_00535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JKF54_00540	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JKF54_00545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JKF54_00555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JKF54_00570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JKF54_00580	COG3577	Aspartyl protease
JKF54_00605	COG0756	dUTP diphosphatase activity
JKF54_00635	COG0736	holo-[acyl-carrier-protein] synthase activity
JKF54_00660	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JKF54_00680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JKF54_00695	COG0284	orotidine-5'-phosphate decarboxylase activity
JKF54_00710	COG0525	valine-tRNA ligase activity
JKF54_00720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JKF54_00740	COG4974	Belongs to the 'phage' integrase family
JKF54_00745	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JKF54_00750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JKF54_00755	COG1981	membrane
JKF54_00760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JKF54_00765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JKF54_00770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JKF54_00775	COG0109	protoheme IX farnesyltransferase activity
JKF54_00790	COG0215	cysteine-tRNA ligase activity
JKF54_00795	COG3932	Exopolysaccharide synthesis, ExoD
JKF54_00805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JKF54_00825	COG1494	fructose-1,6-bisphosphatase
JKF54_00835	COG0012	GTP binding
JKF54_00890	COG2003	Belongs to the UPF0758 family
JKF54_00950	COG3547	Transposase (IS116 IS110 IS902 family)
JKF54_01010	COG2003	Belongs to the UPF0758 family
JKF54_01030	COG0697	spore germination
JKF54_01035	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JKF54_01055	COG1132	(ABC) transporter
JKF54_01075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JKF54_01080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JKF54_01095	COG2801	Transposase and inactivated derivatives
JKF54_01140	COG4804	nuclease activity
JKF54_01210	COG0450	alkyl hydroperoxide reductase
JKF54_01225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JKF54_01230	COG1121	(ABC) transporter
JKF54_01245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JKF54_01250	COG1530	ribonuclease E activity
JKF54_01255	COG0443	Heat shock 70 kDa protein
JKF54_01260	COG0271	Belongs to the BolA IbaG family
JKF54_01265	COG0626	cystathionine gamma-synthase activity
JKF54_01275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JKF54_01285	COG0009	L-threonylcarbamoyladenylate synthase
JKF54_01290	COG0470	DNA polymerase III
JKF54_01310	COG0305	Participates in initiation and elongation during chromosome replication
JKF54_01320	COG1714	RDD family
JKF54_01335	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JKF54_01340	COG0237	dephospho-CoA kinase activity
JKF54_01355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JKF54_01385	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JKF54_01400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JKF54_01405	COG0459	protein refolding
JKF54_01415	COG1115	amino acid carrier protein
JKF54_01425	COG0424	maF-like protein
JKF54_01440	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JKF54_01450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JKF54_01455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JKF54_01460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JKF54_01480	COG2814	Major facilitator Superfamily
JKF54_01490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JKF54_01500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JKF54_01525	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JKF54_01535	COG0575	Belongs to the CDS family
JKF54_01540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JKF54_01555	COG0508	dehydrogenase complex catalyzes the overall conversion of
JKF54_01630	COG2003	Belongs to the UPF0758 family
JKF54_01665	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JKF54_01680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JKF54_01690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JKF54_01705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JKF54_01725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JKF54_01740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JKF54_01745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JKF54_01750	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JKF54_01755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JKF54_01765	COG1450	Type ii and iii secretion system protein
JKF54_01770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JKF54_01770	COG0519	Catalyzes the synthesis of GMP from XMP
JKF54_01775	COG1253	flavin adenine dinucleotide binding
JKF54_01790	COG0481	GTPase activity
JKF54_01805	COG0196	riboflavin kinase activity
JKF54_01810	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JKF54_01815	COG0612	Peptidase, M16
JKF54_01825	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JKF54_01845	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JKF54_01850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JKF54_01860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JKF54_01865	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JKF54_01900	COG0567	Dehydrogenase, E1 component
JKF54_01915	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JKF54_01920	COG0142	geranyltranstransferase activity
JKF54_01925	COG0228	four-way junction DNA binding
JKF54_01930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JKF54_01945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JKF54_01970	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JKF54_01975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JKF54_01980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JKF54_02000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JKF54_02015	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JKF54_02020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JKF54_02025	COG0254	rRNA binding
JKF54_02040	COG1840	ABC-type Fe3 transport system, periplasmic component
JKF54_02045	COG0540	Belongs to the ATCase OTCase family
JKF54_02060	COG0194	GDP metabolic process
JKF54_02070	COG1053	succinate dehydrogenase
JKF54_02080	COG2171	N-acyltransferase activity
JKF54_02115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JKF54_02120	COG0149	triose-phosphate isomerase activity
JKF54_02130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JKF54_02140	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JKF54_02155	COG3547	Transposase (IS116 IS110 IS902 family)
JKF54_02170	COG0473	3-isopropylmalate dehydrogenase activity
JKF54_02185	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JKF54_02200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JKF54_02200	COG0085	RNA polymerase activity
JKF54_02205	COG0222	ribosome binding
JKF54_02210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JKF54_02215	COG0081	regulation of translation
JKF54_02220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JKF54_02225	COG0250	Participates in transcription elongation, termination and antitermination
JKF54_02240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JKF54_02245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JKF54_02250	COG0049	tRNA binding
JKF54_02255	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JKF54_02260	COG2890	protein-(glutamine-N5) methyltransferase activity
JKF54_02260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JKF54_02280	COG0544	peptidyl-prolyl cis-trans isomerase activity
JKF54_02285	COG0740	serine-type endopeptidase activity
JKF54_02290	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JKF54_02295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JKF54_02300	COG0768	penicillin binding
JKF54_02305	COG0726	polysaccharide deacetylase
JKF54_02310	COG0606	chelatase, subunit chli
JKF54_02335	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JKF54_02340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JKF54_02355	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JKF54_02360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JKF54_02365	COG0745	RESPONSE REGULATOR receiver
JKF54_02380	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
JKF54_02385	COG0343	queuine tRNA-ribosyltransferase activity
JKF54_02395	COG0612	Peptidase, M16
JKF54_02400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JKF54_02415	COG0742	ribosomal rna small subunit methyltransferase
JKF54_02430	COG3704	protein secretion by the type IV secretion system
JKF54_02430	COG1340	protein secretion by the type IV secretion system
JKF54_02435	COG3704	protein secretion by the type IV secretion system
JKF54_02440	COG3704	protein secretion by the type IV secretion system
JKF54_02445	COG3451	type IV secretory pathway VirB4
JKF54_02455	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
JKF54_02465	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JKF54_02470	COG3827	peptidoglycan binding
JKF54_02480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JKF54_02495	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JKF54_02505	COG0071	Belongs to the small heat shock protein (HSP20) family
JKF54_02510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JKF54_02520	COG4770	biotin carboxylase activity
JKF54_02525	COG1612	heme a metabolic process
JKF54_02530	COG1215	transferase activity, transferring glycosyl groups
JKF54_02545	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JKF54_02550	COG0356	it plays a direct role in the translocation of protons across the membrane
JKF54_02560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JKF54_02560	COG0072	phenylalanine-tRNA ligase activity
JKF54_02570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JKF54_02580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JKF54_02585	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JKF54_02590	COG0649	NAD binding
JKF54_02600	COG2070	2-Nitropropane dioxygenase
JKF54_02615	COG3451	type IV secretory pathway VirB4
JKF54_02625	COG0666	response to abiotic stimulus
JKF54_02650	COG0006	proline dipeptidase activity
JKF54_02655	COG0445	tRNA wobble uridine modification
JKF54_02670	COG0728	peptidoglycan biosynthetic process
JKF54_02690	COG4695	Portal protein
JKF54_02705	COG0321	lipoyl(octanoyl) transferase activity
JKF54_02730	COG0360	Binds together with S18 to 16S ribosomal RNA
JKF54_02740	COG0359	binds to the 23S rRNA
JKF54_02745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JKF54_02765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JKF54_02815	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
JKF54_02855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JKF54_02915	COG1054	Belongs to the UPF0176 family
JKF54_02920	COG1178	ABC-type Fe3 transport system permease component
JKF54_02930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JKF54_02935	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JKF54_02945	COG1113	amino acid transport
JKF54_02950	COG0531	amino acid
JKF54_02960	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JKF54_02965	COG0124	histidyl-tRNA synthetase
JKF54_02975	COG0484	heat shock protein binding
JKF54_02990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JKF54_02995	COG2857	Cytochrome c1
JKF54_02995	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JKF54_03000	COG0556	nucleotide-excision repair
JKF54_03010	COG0776	regulation of translation
JKF54_03025	COG0495	leucyl-tRNA aminoacylation
JKF54_03040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JKF54_03045	COG0163	prenyltransferase activity
JKF54_03050	COG3750	Belongs to the UPF0335 family
JKF54_03055	COG4536	flavin adenine dinucleotide binding
JKF54_03065	COG0105	UTP biosynthetic process
JKF54_03075	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JKF54_03090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JKF54_03095	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JKF54_03105	COG0142	geranyltranstransferase activity
JKF54_03110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JKF54_03115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JKF54_03125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JKF54_03130	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
JKF54_03150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JKF54_03160	COG0482	sulfurtransferase activity
JKF54_03175	COG2885	chlorophyll binding
JKF54_03185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JKF54_03200	COG0508	dehydrogenase complex catalyzes the overall conversion of
JKF54_03220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JKF54_03230	COG2205	protein histidine kinase activity
JKF54_03235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JKF54_03245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JKF54_03250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JKF54_03260	COG0156	8-amino-7-oxononanoate synthase activity
JKF54_03280	COG0326	Molecular chaperone. Has ATPase activity
JKF54_03295	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JKF54_03345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JKF54_03350	COG0543	2 iron, 2 sulfur cluster binding
JKF54_03350	COG0493	'glutamate synthase
JKF54_03375	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
JKF54_03385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JKF54_03410	COG0629	single-stranded DNA binding
JKF54_03415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JKF54_03435	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
JKF54_03440	COG0670	Belongs to the BI1 family
JKF54_03445	COG1104	cysteine desulfurase activity
JKF54_03450	COG2945	thiolester hydrolase activity
JKF54_03465	COG0316	Belongs to the HesB IscA family
JKF54_03470	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JKF54_03475	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JKF54_03475	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JKF54_03485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JKF54_03490	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JKF54_03495	COG1185	polyribonucleotide nucleotidyltransferase activity
JKF54_03500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JKF54_03515	COG0126	phosphoglycerate kinase activity
JKF54_03520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JKF54_03540	COG0436	Aminotransferase
JKF54_03545	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JKF54_03550	COG1253	flavin adenine dinucleotide binding
JKF54_03585	COG0651	ATP synthesis coupled electron transport
JKF54_03590	COG0772	Belongs to the SEDS family
JKF54_03595	COG1104	cysteine desulfurase activity
JKF54_03615	COG0492	ferredoxin-NADP+ reductase activity
JKF54_03640	COG4974	Belongs to the 'phage' integrase family
JKF54_03650	COG0268	Binds directly to 16S ribosomal RNA
JKF54_03655	COG0372	Belongs to the citrate synthase family
JKF54_03670	COG2827	Endonuclease containing a URI domain
JKF54_03680	COG2255	four-way junction helicase activity
JKF54_03685	COG0632	four-way junction helicase activity
JKF54_03690	COG3474	cytochrome
JKF54_03710	COG0839	Belongs to the complex I subunit 6 family
JKF54_03715	COG0713	ATP synthesis coupled electron transport
JKF54_03720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JKF54_03725	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JKF54_03730	COG1007	ATP synthesis coupled electron transport
JKF54_03735	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
JKF54_03735	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
JKF54_03740	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
JKF54_03775	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
JKF54_03780	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JKF54_03785	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JKF54_03790	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JKF54_03810	COG0628	permease
JKF54_03825	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JKF54_03825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JKF54_03830	COG1475	DNA binding
JKF54_03860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JKF54_03875	COG0045	succinate-CoA ligase (ADP-forming) activity
JKF54_03900	COG1268	BioY protein
JKF54_03925	COG0723	plastoquinol--plastocyanin reductase activity
JKF54_03935	COG0312	modulator of DNA gyrase
JKF54_03955	COG0285	dihydrofolate synthase activity
JKF54_03970	COG2867	negative regulation of translational initiation
JKF54_04005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JKF54_04010	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JKF54_04020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JKF54_04035	COG0101	tRNA pseudouridine synthase activity
JKF54_04040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JKF54_04050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JKF54_04060	COG0275	rRNA processing
JKF54_04070	COG0024	Methionine aminopeptidase
JKF54_04075	COG0849	cell division
JKF54_04080	COG0242	peptide deformylase activity
JKF54_04085	COG1573	uracil-dna glycosylase
JKF54_04090	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
JKF54_04100	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JKF54_04110	COG1295	ribonuclease BN
JKF54_04115	COG4221	oxidoreductase activity
JKF54_04125	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JKF54_04130	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JKF54_04135	COG0564	pseudouridine synthase activity
JKF54_04155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JKF54_04175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JKF54_04180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JKF54_04190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JKF54_04200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JKF54_04235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JKF54_04265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JKF54_04270	COG0259	pyridoxamine-phosphate oxidase activity
JKF54_04275	COG0047	phosphoribosylformylglycinamidine synthase activity
JKF54_04280	COG0581	inorganic phosphate transmembrane transporter activity
JKF54_04285	COG0335	large ribosomal subunit rRNA binding
JKF54_04290	COG0336	Belongs to the RNA methyltransferase TrmD family
JKF54_04295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JKF54_04300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JKF54_04320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JKF54_04335	COG2094	Belongs to the DNA glycosylase MPG family
JKF54_04345	COG0489	protein tyrosine kinase activity
JKF54_04365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JKF54_04370	COG0799	negative regulation of ribosome biogenesis
JKF54_04380	COG0494	nUDIX hydrolase
JKF54_04385	COG0084	hydrolase, TatD family'
JKF54_04390	COG0039	L-malate dehydrogenase activity
JKF54_04395	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JKF54_04400	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JKF54_04405	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JKF54_04430	COG1090	epimerase
JKF54_04440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JKF54_04445	COG0416	fatty acid biosynthetic process
JKF54_04450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JKF54_04455	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JKF54_04460	COG1127	ABC transporter
JKF54_04465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JKF54_04480	COG0493	'glutamate synthase
JKF54_04480	COG0543	2 iron, 2 sulfur cluster binding
JKF54_04485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JKF54_04500	COG0750	zinc metalloprotease
JKF54_04515	COG0776	regulation of translation
JKF54_04520	COG0539	negative regulation of cytoplasmic translation
JKF54_04525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JKF54_04565	COG0330	HflC and HflK could
JKF54_04580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JKF54_04595	COG1758	RNA polymerase activity
JKF54_04605	COG1320	monovalent cation:proton antiporter activity
JKF54_04610	COG2111	Na H antiporter
JKF54_04610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JKF54_04620	COG1006	Multisubunit Na H antiporter MnhC subunit
JKF54_04625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JKF54_04650	COG2009	succinate dehydrogenase
JKF54_04655	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JKF54_04670	COG4591	ABC-type transport system involved in lipoprotein release permease component
JKF54_04685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JKF54_04690	COG0312	modulator of DNA gyrase
JKF54_04695	COG1278	Cold shock
JKF54_04705	COG0542	response to heat
JKF54_04715	COG1830	Aldolase
JKF54_04725	COG0167	dihydroorotate dehydrogenase activity
JKF54_04730	COG0571	ribonuclease III activity
JKF54_04740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JKF54_04750	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
JKF54_04755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JKF54_04770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JKF54_04780	COG1034	ATP synthesis coupled electron transport
JKF54_04790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JKF54_04795	COG0113	porphobilinogen synthase activity
JKF54_04805	COG0752	glycyl-tRNA synthetase alpha subunit
JKF54_04810	COG0751	glycine-tRNA ligase activity
JKF54_04815	COG0322	excinuclease ABC activity
JKF54_04825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JKF54_04850	COG1230	cation diffusion facilitator family transporter
JKF54_04860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JKF54_04865	COG1115	amino acid carrier protein
JKF54_04870	COG1115	amino acid carrier protein
JKF54_04875	COG1183	phosphatidylcholine synthase activity
JKF54_04895	COG0187	DNA topoisomerase II activity
JKF54_04900	COG0154	amidase activity
JKF54_04905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JKF54_04905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JKF54_04935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JKF54_04945	COG0307	riboflavin synthase, alpha
JKF54_04955	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JKF54_04960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JKF54_04980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JKF54_04985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JKF54_04995	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JKF54_05000	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JKF54_05010	COG1845	cytochrome c oxidase, subunit III
JKF54_05020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JKF54_05025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JKF54_05025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JKF54_05050	COG0594	ribonuclease P activity
JKF54_05055	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JKF54_05060	COG0573	inorganic phosphate transmembrane transporter activity
JKF54_05065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JKF54_05070	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JKF54_05110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JKF54_05115	COG0051	transcription antitermination factor activity, RNA binding
JKF54_05120	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JKF54_05125	COG0088	Forms part of the polypeptide exit tunnel
JKF54_05135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JKF54_05140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JKF54_05145	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JKF54_05150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JKF54_05155	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JKF54_05160	COG0255	Belongs to the universal ribosomal protein uL29 family
JKF54_05170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JKF54_05175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JKF54_05180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JKF54_05185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JKF54_05190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JKF54_05200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JKF54_05205	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JKF54_05210	COG0200	Binds to the 23S rRNA
JKF54_05215	COG0201	protein transport
JKF54_05220	COG0563	adenylate kinase activity
JKF54_05225	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JKF54_05230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JKF54_05235	COG0202	RNA polymerase activity
JKF54_05240	COG0203	ribosomal protein L17
JKF54_05245	COG0792	nuclease activity
JKF54_05255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JKF54_05260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JKF54_05265	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JKF54_05265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JKF54_05285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JKF54_05285	COG0574	Belongs to the PEP-utilizing enzyme family
JKF54_05295	COG1566	PFAM secretion protein HlyD family protein
JKF54_05300	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JKF54_05310	COG0280	phosphate acetyltransferase
JKF54_05310	COG0281	malic enzyme
JKF54_05315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JKF54_05330	COG0217	transcriptional regulatory protein
JKF54_05335	COG0739	heme binding
JKF54_05360	COG2814	Major facilitator Superfamily
JKF54_05365	COG2226	methyltransferase
JKF54_05370	COG1132	(ABC) transporter
JKF54_05390	COG0018	arginyl-trna synthetase
JKF54_05395	COG4133	protoheme IX ABC transporter activity
JKF54_05410	COG0590	tRNA wobble adenosine to inosine editing
JKF54_05420	COG0504	CTP synthase activity
JKF54_05455	COG1862	Preprotein translocase
JKF54_05465	COG0052	Belongs to the universal ribosomal protein uS2 family
JKF54_05470	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JKF54_05475	COG0528	UMP kinase activity
JKF54_05480	COG0233	cytoplasmic translational termination
JKF54_05495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JKF54_05500	COG0717	Belongs to the dCTP deaminase family
JKF54_05525	COG3736	Type IV secretory pathway, component VirB8
JKF54_05540	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
JKF54_05555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JKF54_05560	COG0477	Major facilitator Superfamily
JKF54_05565	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JKF54_05570	COG0552	protein localization to endoplasmic reticulum
JKF54_05575	COG0822	iron-sulfur transferase activity
JKF54_05580	COG0316	Belongs to the HesB IscA family
JKF54_05590	COG0443	Heat shock 70 kDa protein
JKF54_05595	COG0681	Belongs to the peptidase S26 family
JKF54_05605	COG0508	dehydrogenase complex catalyzes the overall conversion of
JKF54_05605	COG0022	dehydrogenase e1 component
JKF54_05630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JKF54_05680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JKF54_05685	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JKF54_05705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JKF54_05710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JKF54_05730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JKF54_05735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JKF54_05740	COG0823	Involved in the tonB-independent uptake of proteins
JKF54_05750	COG0484	heat shock protein binding
JKF54_05765	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JKF54_05770	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
JKF54_05780	COG0114	fumarate hydratase activity
JKF54_05810	COG3346	SURF1 family
JKF54_05825	COG0148	phosphopyruvate hydratase activity
JKF54_05830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JKF54_05855	COG1674	ftsk spoiiie
JKF54_05870	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JKF54_05895	COG0235	Class ii aldolase
JKF54_05915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JKF54_05920	COG0358	DNA primase activity
JKF54_05940	COG3088	subunit of a heme lyase
JKF54_05945	COG1074	ATP-dependent DNA helicase activity
JKF54_05960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JKF54_05975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JKF54_05975	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
JKF54_05980	COG1217	gtp-binding protein TYPA
JKF54_05985	COG0617	tRNA 3'-terminal CCA addition
JKF54_06020	COG0805	protein transport
JKF54_06045	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JKF54_06065	COG0653	protein targeting