locus-tag	class	description
HUB92_00015	COG1862	Preprotein translocase
HUB92_00025	COG0052	Belongs to the universal ribosomal protein uS2 family
HUB92_00030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUB92_00035	COG0528	UMP kinase activity
HUB92_00040	COG0233	cytoplasmic translational termination
HUB92_00050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUB92_00055	COG0575	Belongs to the CDS family
HUB92_00065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUB92_00085	COG2801	Transposase and inactivated derivatives
HUB92_00100	COG2963	transposase activity
HUB92_00130	COG0154	amidase activity
HUB92_00140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUB92_00165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUB92_00170	COG0148	phosphopyruvate hydratase activity
HUB92_00185	COG0114	fumarate hydratase activity
HUB92_00205	COG0281	malic enzyme
HUB92_00205	COG0280	phosphate acetyltransferase
HUB92_00210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUB92_00220	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUB92_00225	COG0217	transcriptional regulatory protein
HUB92_00230	COG0739	heme binding
HUB92_00265	COG0481	GTPase activity
HUB92_00275	COG1115	amino acid carrier protein
HUB92_00290	COG0424	maF-like protein
HUB92_00310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUB92_00325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUB92_00360	COG2801	Transposase and inactivated derivatives
HUB92_00375	COG0358	DNA primase activity
HUB92_00385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUB92_00395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUB92_00410	COG1714	RDD family
HUB92_00420	COG0305	Participates in initiation and elongation during chromosome replication
HUB92_00450	COG1074	ATP-dependent DNA helicase activity
HUB92_00465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUB92_00485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUB92_00505	COG2801	Transposase and inactivated derivatives
HUB92_00515	COG2239	Acts as a magnesium transporter
HUB92_00520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUB92_00575	COG2814	Major facilitator Superfamily
HUB92_00615	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HUB92_00640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUB92_00645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUB92_00650	COG2226	methyltransferase
HUB92_00670	COG1132	(ABC) transporter
HUB92_00680	COG0018	arginyl-trna synthetase
HUB92_00705	COG4133	protoheme IX ABC transporter activity
HUB92_00720	COG0477	Major facilitator Superfamily
HUB92_00725	COG0564	pseudouridine synthase activity
HUB92_00730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUB92_00735	COG1981	membrane
HUB92_00745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUB92_00755	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUB92_00765	COG0072	phenylalanine-tRNA ligase activity
HUB92_00765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUB92_00780	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUB92_00805	COG4770	biotin carboxylase activity
HUB92_00815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUB92_00820	COG1053	succinate dehydrogenase
HUB92_00830	COG0194	GDP metabolic process
HUB92_00855	COG0012	GTP binding
HUB92_00865	COG0617	tRNA 3'-terminal CCA addition
HUB92_00925	COG0805	protein transport
HUB92_00930	COG1438	arginine binding
HUB92_00935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUB92_00940	COG0765	amino acid transport
HUB92_00945	COG1126	abc transporter atp-binding protein
HUB92_00965	COG0284	orotidine-5'-phosphate decarboxylase activity
HUB92_00990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUB92_00995	COG0525	valine-tRNA ligase activity
HUB92_01015	COG0504	CTP synthase activity
HUB92_01020	COG0590	tRNA wobble adenosine to inosine editing
HUB92_01050	COG0477	Major facilitator Superfamily
HUB92_01070	COG0022	dehydrogenase e1 component
HUB92_01070	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUB92_01110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUB92_01140	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUB92_01150	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUB92_01155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUB92_01175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUB92_01185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUB92_01195	COG0354	folic acid binding
HUB92_01200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUB92_01205	COG0459	protein refolding
HUB92_01220	COG0109	protoheme IX farnesyltransferase activity
HUB92_01225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUB92_01230	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUB92_01235	COG2801	Transposase and inactivated derivatives
HUB92_01415	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HUB92_01465	COG3620	sequence-specific DNA binding
HUB92_01655	COG2801	Transposase and inactivated derivatives
HUB92_01665	COG2963	transposase activity
HUB92_01670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUB92_01705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUB92_01715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUB92_01720	COG0792	nuclease activity
HUB92_01730	COG0202	RNA polymerase activity
HUB92_01735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUB92_01740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUB92_01750	COG0201	protein transport
HUB92_01760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUB92_01770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUB92_01780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUB92_01815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUB92_01830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUB92_01835	COG0089	rRNA binding
HUB92_01845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUB92_01855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUB92_01870	COG0505	Belongs to the CarA family
HUB92_01885	COG1494	fructose-1,6-bisphosphatase
HUB92_01895	COG0574	Belongs to the PEP-utilizing enzyme family
HUB92_01895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUB92_01910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUB92_01930	COG3547	Transposase (IS116 IS110 IS902 family)
HUB92_01935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUB92_01950	COG1104	cysteine desulfurase activity
HUB92_01955	COG2945	thiolester hydrolase activity
HUB92_01970	COG0316	Belongs to the HesB IscA family
HUB92_01975	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUB92_01980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUB92_01980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUB92_01990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUB92_02000	COG2171	N-acyltransferase activity
HUB92_02055	COG1845	cytochrome c oxidase, subunit III
HUB92_02065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUB92_02110	COG3736	Type IV secretory pathway, component VirB8
HUB92_02125	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HUB92_02130	COG3505	Type IV secretory pathway VirD4
HUB92_02140	COG2890	protein-(glutamine-N5) methyltransferase activity
HUB92_02155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUB92_02170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUB92_02185	COG0250	Participates in transcription elongation, termination and antitermination
HUB92_02190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUB92_02195	COG0081	regulation of translation
HUB92_02200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUB92_02205	COG0222	ribosome binding
HUB92_02210	COG0085	RNA polymerase activity
HUB92_02210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUB92_02215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUB92_02225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUB92_02250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUB92_02255	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUB92_02260	COG0823	Involved in the tonB-independent uptake of proteins
HUB92_02305	COG0305	Participates in initiation and elongation during chromosome replication
HUB92_02315	COG1714	RDD family
HUB92_02360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUB92_02375	COG0776	regulation of translation
HUB92_02390	COG0495	leucyl-tRNA aminoacylation
HUB92_02400	COG2801	Transposase and inactivated derivatives
HUB92_02415	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HUB92_02440	COG3827	peptidoglycan binding
HUB92_02445	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HUB92_02475	COG2801	Transposase and inactivated derivatives
HUB92_02505	COG0489	protein tyrosine kinase activity
HUB92_02515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUB92_02525	COG0193	aminoacyl-tRNA hydrolase activity
HUB92_02545	COG0275	rRNA processing
HUB92_02555	COG0024	Methionine aminopeptidase
HUB92_02560	COG0849	cell division
HUB92_02565	COG0242	peptide deformylase activity
HUB92_02570	COG1573	uracil-dna glycosylase
HUB92_02600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUB92_02605	COG0113	porphobilinogen synthase activity
HUB92_02615	COG0752	glycyl-tRNA synthetase alpha subunit
HUB92_02635	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HUB92_02640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUB92_02650	COG3932	Exopolysaccharide synthesis, ExoD
HUB92_02695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUB92_02720	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUB92_02730	COG1845	cytochrome c oxidase, subunit III
HUB92_02755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUB92_02760	COG1121	(ABC) transporter
HUB92_02780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUB92_02785	COG1530	ribonuclease E activity
HUB92_02800	COG0626	cystathionine gamma-synthase activity
HUB92_02850	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUB92_02870	COG0567	Dehydrogenase, E1 component
HUB92_02880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUB92_02905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUB92_02905	COG2111	Na H antiporter
HUB92_02915	COG1006	Multisubunit Na H antiporter MnhC subunit
HUB92_02920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUB92_02960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUB92_02970	COG1028	Short-chain dehydrogenase reductase Sdr
HUB92_02975	COG1295	ribonuclease BN
HUB92_03005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUB92_03010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUB92_03015	COG2202	Pas domain
HUB92_03015	COG2205	protein histidine kinase activity
HUB92_03020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUB92_03030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUB92_03040	COG0156	8-amino-7-oxononanoate synthase activity
HUB92_03050	COG0326	Molecular chaperone. Has ATPase activity
HUB92_03060	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUB92_03065	COG0768	penicillin binding
HUB92_03075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HUB92_03090	COG0543	2 iron, 2 sulfur cluster binding
HUB92_03090	COG0493	'glutamate synthase
HUB92_03095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUB92_03110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUB92_03120	COG0482	sulfurtransferase activity
HUB92_03135	COG2885	chlorophyll binding
HUB92_03140	COG0037	tRNA processing
HUB92_03145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUB92_03160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUB92_03220	COG0167	dihydroorotate dehydrogenase activity
HUB92_03230	COG1830	Aldolase
HUB92_03240	COG0513	Belongs to the DEAD box helicase family
HUB92_03245	COG1278	Cold shock
HUB92_03250	COG0312	modulator of DNA gyrase
HUB92_03255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUB92_03270	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUB92_03295	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HUB92_03295	COG0662	Cupin 2, conserved barrel domain protein
HUB92_03305	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HUB92_03310	COG2009	succinate dehydrogenase
HUB92_03330	COG1475	DNA binding
HUB92_03360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUB92_03375	COG0045	succinate-CoA ligase (ADP-forming) activity
HUB92_03380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HUB92_03390	COG0778	Nitroreductase
HUB92_03395	COG1268	BioY protein
HUB92_03440	COG0723	plastoquinol--plastocyanin reductase activity
HUB92_03455	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HUB92_03470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUB92_03475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUB92_03480	COG0142	geranyltranstransferase activity
HUB92_03490	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HUB92_03520	COG0105	UTP biosynthetic process
HUB92_03530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUB92_03545	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUB92_03580	COG2070	2-Nitropropane dioxygenase
HUB92_03590	COG0126	phosphoglycerate kinase activity
HUB92_03630	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUB92_03635	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUB92_03640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUB92_03645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUB92_03655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUB92_03665	COG0174	glutamine synthetase
HUB92_03670	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUB92_03720	COG0839	Belongs to the complex I subunit 6 family
HUB92_03725	COG0713	ATP synthesis coupled electron transport
HUB92_03730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUB92_03735	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUB92_03740	COG1007	ATP synthesis coupled electron transport
HUB92_03745	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HUB92_03745	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HUB92_03795	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUB92_03800	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUB92_03805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUB92_03815	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUB92_03820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HUB92_03830	COG0492	ferredoxin-NADP+ reductase activity
HUB92_03835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUB92_03845	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUB92_03850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUB92_03855	COG1127	ABC transporter
HUB92_03865	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUB92_03875	COG1104	cysteine desulfurase activity
HUB92_03885	COG0312	modulator of DNA gyrase
HUB92_03915	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUB92_03915	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUB92_03920	COG2801	Transposase and inactivated derivatives
HUB92_03960	COG0445	tRNA wobble uridine modification
HUB92_03980	COG4695	Portal protein
HUB92_03990	COG0321	lipoyl(octanoyl) transferase activity
HUB92_04005	COG0047	phosphoribosylformylglycinamidine synthase activity
HUB92_04030	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUB92_04035	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUB92_04050	COG1253	flavin adenine dinucleotide binding
HUB92_04055	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUB92_04060	COG0436	Aminotransferase
HUB92_04100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUB92_04125	COG1230	cation diffusion facilitator family transporter
HUB92_04150	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUB92_04155	COG1115	amino acid carrier protein
HUB92_04160	COG1115	amino acid carrier protein
HUB92_04165	COG1183	phosphatidylcholine synthase activity
HUB92_04175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUB92_04180	COG0484	heat shock protein binding
HUB92_04185	COG0285	dihydrofolate synthase activity
HUB92_04200	COG2867	negative regulation of translational initiation
HUB92_04235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUB92_04240	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUB92_04250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUB92_04265	COG0101	tRNA pseudouridine synthase activity
HUB92_04280	COG2857	Cytochrome c1
HUB92_04280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUB92_04290	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUB92_04305	COG0484	heat shock protein binding
HUB92_04315	COG0124	histidyl-tRNA synthetase
HUB92_04325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUB92_04335	COG0543	2 iron, 2 sulfur cluster binding
HUB92_04335	COG0493	'glutamate synthase
HUB92_04340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUB92_04355	COG0750	zinc metalloprotease
HUB92_04370	COG0776	regulation of translation
HUB92_04375	COG0539	negative regulation of cytoplasmic translation
HUB92_04380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUB92_04405	COG1160	GTP binding
HUB92_04415	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HUB92_04420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUB92_04425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUB92_04445	COG0651	ATP synthesis coupled electron transport
HUB92_04450	COG0772	Belongs to the SEDS family
HUB92_04455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HUB92_04460	COG2094	Belongs to the DNA glycosylase MPG family
HUB92_04480	COG2255	four-way junction helicase activity
HUB92_04535	COG0084	hydrolase, TatD family'
HUB92_04545	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUB92_04555	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUB92_04580	COG1090	epimerase
HUB92_04610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUB92_04615	COG1054	Belongs to the UPF0176 family
HUB92_04620	COG1178	ABC-type Fe3 transport system permease component
HUB92_04635	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUB92_04640	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUB92_04640	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUB92_04645	COG0628	permease
HUB92_04655	COG4974	Belongs to the 'phage' integrase family
HUB92_04670	COG0372	Belongs to the citrate synthase family
HUB92_04690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUB92_04705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUB92_04710	COG0259	pyridoxamine-phosphate oxidase activity
HUB92_04740	COG1185	polyribonucleotide nucleotidyltransferase activity
HUB92_04750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUB92_04770	COG3547	Transposase (IS116 IS110 IS902 family)
HUB92_04850	COG0527	aspartate kinase activity
HUB92_04865	COG0531	amino acid
HUB92_04885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUB92_04895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUB92_04900	COG0670	Belongs to the BI1 family
HUB92_04905	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HUB92_04930	COG3547	Transposase (IS116 IS110 IS902 family)
HUB92_04945	COG1840	ABC-type Fe3 transport system, periplasmic component
HUB92_04955	COG0681	Belongs to the peptidase S26 family
HUB92_04965	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HUB92_04970	COG0316	Belongs to the HesB IscA family
HUB92_04975	COG0822	iron-sulfur transferase activity
HUB92_04980	COG0552	protein localization to endoplasmic reticulum
HUB92_04985	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUB92_05000	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUB92_05000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUB92_05010	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HUB92_05050	COG2963	transposase activity
HUB92_05060	COG2801	Transposase and inactivated derivatives
HUB92_05080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUB92_05085	COG0254	rRNA binding
HUB92_05090	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUB92_05100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HUB92_05135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUB92_05150	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HUB92_05160	COG3451	type IV secretory pathway VirB4
HUB92_05165	COG3704	protein secretion by the type IV secretion system
HUB92_05170	COG3704	protein secretion by the type IV secretion system
HUB92_05175	COG3704	protein secretion by the type IV secretion system
HUB92_05175	COG1340	protein secretion by the type IV secretion system
HUB92_05190	COG0742	ribosomal rna small subunit methyltransferase
HUB92_05205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUB92_05220	COG4235	cytochrome complex assembly
HUB92_05220	COG3088	subunit of a heme lyase
HUB92_05250	COG0556	nucleotide-excision repair
HUB92_05280	COG0330	HflC and HflK could
HUB92_05320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUB92_05330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUB92_05340	COG0009	L-threonylcarbamoyladenylate synthase
HUB92_05370	COG0736	holo-[acyl-carrier-protein] synthase activity
HUB92_05375	COG0442	prolyl-tRNA aminoacylation
HUB92_05400	COG3474	cytochrome
HUB92_05420	COG0142	geranyltranstransferase activity
HUB92_05445	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HUB92_05470	COG0473	3-isopropylmalate dehydrogenase activity
HUB92_05495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUB92_05510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUB92_05525	COG0359	binds to the 23S rRNA
HUB92_05535	COG0360	Binds together with S18 to 16S ribosomal RNA
HUB92_05545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUB92_05555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUB92_05560	COG0629	single-stranded DNA binding
HUB92_05590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUB92_05615	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HUB92_05625	COG0612	Peptidase, M16
HUB92_05630	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUB92_05635	COG0196	riboflavin kinase activity
HUB92_05650	COG0450	alkyl hydroperoxide reductase
HUB92_05675	COG4974	Belongs to the 'phage' integrase family
HUB92_05680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUB92_05720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUB92_05725	COG1294	oxidase, subunit
HUB92_05730	COG1271	oxidase subunit
HUB92_05735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUB92_05740	COG0612	Peptidase, M16
HUB92_05750	COG0343	queuine tRNA-ribosyltransferase activity
HUB92_05755	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HUB92_05770	COG0745	RESPONSE REGULATOR receiver
HUB92_05775	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUB92_05780	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HUB92_05795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUB92_05835	COG0768	penicillin binding
HUB92_05845	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUB92_05855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUB92_05865	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUB92_05870	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUB92_05885	COG0307	riboflavin synthase, alpha
HUB92_05940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUB92_05965	COG0187	DNA topoisomerase II activity
HUB92_05980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUB92_05995	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUB92_06020	COG1686	Belongs to the peptidase S11 family
HUB92_06035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUB92_06050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HUB92_06070	COG0149	triose-phosphate isomerase activity
HUB92_06105	COG2801	Transposase and inactivated derivatives
HUB92_06110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUB92_06115	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUB92_06140	COG2801	Transposase and inactivated derivatives
HUB92_06155	COG0237	dephospho-CoA kinase activity
HUB92_06160	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HUB92_06165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUB92_06175	COG1253	flavin adenine dinucleotide binding
HUB92_06185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUB92_06185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUB92_06220	COG0573	inorganic phosphate transmembrane transporter activity
HUB92_06225	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUB92_06230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUB92_06240	COG2801	Transposase and inactivated derivatives
HUB92_06255	COG0235	Class ii aldolase
HUB92_06290	COG4804	nuclease activity
HUB92_06300	COG1381	Involved in DNA repair and RecF pathway recombination
HUB92_06315	COG2902	Dehydrogenase
HUB92_06320	COG0542	response to heat
HUB92_06330	COG1217	gtp-binding protein TYPA
HUB92_06335	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUB92_06340	COG1301	dicarboxylic acid transport
HUB92_06360	COG1138	Cytochrome C-type biogenesis protein
HUB92_06375	COG3577	Aspartyl protease
HUB92_06410	COG0756	dUTP diphosphatase activity
HUB92_06415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUB92_06420	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUB92_06425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUB92_06450	COG2801	Transposase and inactivated derivatives
HUB92_06455	COG1322	Protein conserved in bacteria
HUB92_06475	COG0649	NAD binding
HUB92_06480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUB92_06485	COG4536	flavin adenine dinucleotide binding
HUB92_06490	COG3750	Belongs to the UPF0335 family
HUB92_06495	COG0163	prenyltransferase activity
HUB92_06500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUB92_06535	COG0653	protein targeting
HUB92_06555	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUB92_06565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUB92_06585	COG1862	Preprotein translocase
HUB92_06595	COG0052	Belongs to the universal ribosomal protein uS2 family
HUB92_06600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUB92_06605	COG0528	UMP kinase activity
HUB92_06610	COG0233	cytoplasmic translational termination
HUB92_06620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUB92_06635	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUB92_06655	COG2801	Transposase and inactivated derivatives