locus-tag	class	description
CO538_000005	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
CO538_000010	ENOG4105CHM	Aminotransferase
CO538_000015	ENOG4105KPY	Small multidrug resistance protein
CO538_000030	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
CO538_000035	ENOG4105BZA	Phosphoglycerate kinase
CO538_000050	ENOG4105DJV	ribulose-phosphate 3-epimerase
CO538_000060	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
CO538_000065	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
CO538_000085	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_000090	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
CO538_000095	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
CO538_000100	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
CO538_000115	ENOG4105DHZ	alpha beta
CO538_000120	ENOG4107QI6	Cysteine desulfurase
CO538_000125	ENOG4105HFZ	Membrane
CO538_000130	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
CO538_000150	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_000165	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
CO538_000175	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
CO538_000205	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
CO538_000220	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_000230	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
CO538_000240	ENOG4107QX3	carboxylase
CO538_000275	ENOG4108J1Q	
CO538_000285	ENOG4108J1Q	
CO538_000290	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
CO538_000295	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
CO538_000305	ENOG4105C26	Dehydrogenase
CO538_000315	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
CO538_000320	ENOG4105F8V	Hydrolase, tatD family
CO538_000325	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
CO538_000330	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CO538_000335	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CO538_000340	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CO538_000345	ENOG4105K59	histidine triad (HIT) protein
CO538_000365	ENOG4105ECP	epimerase
CO538_000375	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
CO538_000380	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
CO538_000390	ENOG4105CY3	ABC transporter, permease
CO538_000395	ENOG4105DHJ	ABC, transporter
CO538_000420	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
CO538_000430	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CO538_000435	ENOG4105DZP	Membrane-associated zinc metalloprotease
CO538_000450	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
CO538_000455	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
CO538_000460	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
CO538_000505	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
CO538_000510	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
CO538_000525	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
CO538_000545	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
CO538_000555	ENOG4107QJE	Chromosome Partitioning Protein
CO538_000560	ENOG4105FA0	parb-like partition protein
CO538_000565	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
CO538_000580	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_000590	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
CO538_000595	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
CO538_000605	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
CO538_000615	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
CO538_000630	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
CO538_000665	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
CO538_000670	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
CO538_000675	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
CO538_000680	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
CO538_000685	ENOG4105CTB	Polyprenyl synthetase
CO538_000695	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
CO538_000700	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
CO538_000715	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
CO538_000725	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
CO538_000730	ENOG4105C8Y	Acetylornithine aminotransferase
CO538_000735	ENOG4108JU6	CBS domain protein
CO538_000740	ENOG4105Y2X	UPF0335 protein
CO538_000745	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
CO538_000750	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
CO538_000765	ENOG4105C8T	Leucyl-tRNA synthetase
CO538_000775	ENOG4105WJX	transcriptional regulator MERR family
CO538_000780	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
CO538_000830	ENOG4108J1Q	
CO538_000870	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_000885	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
CO538_000890	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
CO538_000900	ENOG4105C0B	DNA polymerase III (alpha subunit)
CO538_000905	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
CO538_000910	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
CO538_000915	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
CO538_000920	ENOG4105C83	adenylosuccinate lyase
CO538_000945	ENOG4108MDK	Dehydrogenase
CO538_000950	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
CO538_000995	ENOG4105EEI	dihydropteroate synthase
CO538_001005	ENOG4107ZH2	Coenzyme PQQ synthesis protein C
CO538_001020	ENOG4108J1Q	
CO538_001055	ENOG4105K63	Thioredoxin
CO538_001060	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
CO538_001075	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
CO538_001100	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_001115	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
CO538_001120	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
CO538_001125	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
CO538_001130	ENOG4108J1Q	
CO538_001145	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
CO538_001155	ENOG4105CUT	histidyl-tRNA synthetase
CO538_001160	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
CO538_001170	ENOG4105D5Q	Arginine ornithine antiporter
CO538_001190	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
CO538_001195	ENOG4105NWN	ApaG protein
CO538_001200	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
CO538_001205	ENOG4105C72	UPF0176 protein
CO538_001275	ENOG4108QTG	type IV secretion system protein
CO538_001295	ENOG4108J1Q	
CO538_001315	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_001320	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
CO538_001325	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
CO538_001330	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
CO538_001340	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
CO538_001350	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
CO538_001355	ENOG41085Y2	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
CO538_001375	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
CO538_001380	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
CO538_001390	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
CO538_001395	ENOG4105VN1	Heat shock protein
CO538_001400	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
CO538_001415	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
CO538_001425	ENOG4106HA5	Protein of unknown function (DUF2497) 
CO538_001430	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
CO538_001455	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
CO538_001465	ENOG4105C1V	Peptidase, M16
CO538_001515	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
CO538_001520	ENOG4105DC7	peptidase M24
CO538_001570	ENOG4105EA8	2-Nitropropane dioxygenase
CO538_001580	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CO538_001590	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_001600	ENOG4108J1Q	
CO538_001610	ENOG4108J1Q	
CO538_001625	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
CO538_001630	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
CO538_001635	ENOG4108ZAI	phosphatidylglycerophosphatase a
CO538_001655	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
CO538_001695	ENOG4105CJN	penicillin-binding protein
CO538_001700	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
CO538_001705	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
CO538_001710	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
CO538_001715	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
CO538_001725	ENOG41082WC	Transport-associated protein
CO538_001740	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
CO538_001745	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_001755	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
CO538_001760	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
CO538_001765	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
CO538_001770	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
CO538_001785	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
CO538_001790	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
CO538_001795	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
CO538_001800	ENOG4108VZM	50s ribosomal protein L10
CO538_001805	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
CO538_001810	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
CO538_001825	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
CO538_001830	ENOG4105C12	Phosphoribosylglycinamide synthetase
CO538_001840	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
CO538_001885	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_001915	ENOG4108J1Q	
CO538_001935	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
CO538_001955	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
CO538_001970	ENOG4105CXT	aspartate transcarbamylase
CO538_001985	ENOG4108J1Q	
CO538_001995	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
CO538_002000	ENOG41082FS	50S ribosomal protein L31
CO538_002005	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
CO538_002015	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
CO538_002030	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
CO538_002050	ENOG41082BR	50S ribosomal protein L35
CO538_002055	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
CO538_002060	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
CO538_002070	ENOG4105DC1	bifunctional purine biosynthesis protein purh
CO538_002075	ENOG4108J1Q	
CO538_002085	ENOG4108J1Q	
CO538_002105	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
CO538_002110	ENOG4108J1Q	
CO538_002120	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
CO538_002135	ENOG4108Z1B	Cyclase dehydrase
CO538_002140	ENOG4107ZQN	disulfide bond
CO538_002170	ENOG4107QMP	dna polymerase iii subunits gamma and tau
CO538_002175	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
CO538_002180	ENOG4108UK9	heat resistant agglutinin 1
CO538_002185	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
CO538_002195	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
CO538_002200	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
CO538_002205	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
CO538_002215	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
CO538_002220	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
CO538_002240	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
CO538_002245	ENOG4105CSH	Transporter
CO538_002250	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
CO538_002255	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
CO538_002260	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
CO538_002265	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
CO538_002280	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
CO538_002295	ENOG4107U9T	Pfam:Ribonuclease_BN
CO538_002300	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
CO538_002305	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
CO538_002325	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
CO538_002345	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
CO538_002355	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
CO538_002360	ENOG4105CFH	Aspartokinase
CO538_002365	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
CO538_002370	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CO538_002375	ENOG4105D7Z	glutathione synthase
CO538_002380	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
CO538_002410	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_002420	ENOG4108J1Q	
CO538_002440	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
CO538_002460	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
CO538_002475	ENOG4105KCK	Peptidoglycan-associated lipoprotein
CO538_002480	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
CO538_002485	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
CO538_002490	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
CO538_002500	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
CO538_002555	ENOG4108JJ6	Type I secretion system ATPase
CO538_002565	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
CO538_002575	ENOG4105BZU	Histidine kinase
CO538_002580	ENOG4105C8Y	Acetylornithine aminotransferase
CO538_002595	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_002610	ENOG4105C02	permease
CO538_002620	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
CO538_002630	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
CO538_002635	ENOG4105BZN	citrate synthase
CO538_002665	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
CO538_002670	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
CO538_002675	ENOG4105G9V	cytochrome C
CO538_002695	ENOG4105DF2	NADH dehydrogenase subunit j
CO538_002700	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CO538_002715	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CO538_002720	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
CO538_002725	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
CO538_002730	ENOG4108J1Q	
CO538_002765	ENOG4108J1Q	
CO538_002800	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_002830	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
CO538_002835	ENOG4105C7I	Dehydrogenase
CO538_002845	ENOG4105BZU	Histidine kinase
CO538_002850	ENOG4107UIS	Involved in DNA repair and RecF pathway recombination (By similarity)
CO538_002880	ENOG4108J1Q	
CO538_002885	ENOG4108J1Q	
CO538_002895	ENOG4105CDU	Replicative dna helicase
CO538_002925	ENOG41082QS	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
CO538_002930	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
CO538_002945	ENOG4108J1Q	
CO538_002960	ENOG4105CFQ	glutamine synthetase
CO538_002965	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
CO538_002970	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
CO538_002980	ENOG4108WIW	Aspartyl protease
CO538_002985	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
CO538_002990	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
CO538_003005	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
CO538_003015	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_003025	ENOG4105D3R	alkyl hydroperoxide reductase
CO538_003035	ENOG4108J1Q	
CO538_003040	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_003080	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_003095	ENOG4108J1Q	
CO538_003105	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
CO538_003110	ENOG4105FDK	ABC transporter
CO538_003115	ENOG4105NXV	High-affinity zinc uptake system protein
CO538_003135	ENOG4105C03	ribonuclease
CO538_003145	ENOG4105M85	Bola protein
CO538_003150	ENOG4105C28	cystathionine
CO538_003155	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
CO538_003160	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
CO538_003170	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
CO538_003195	ENOG4105CDU	Replicative dna helicase
CO538_003205	ENOG4105VQU	rdd domain containing protein
CO538_003215	ENOG4108J1Q	
CO538_003230	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
CO538_003235	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
CO538_003245	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_003250	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_003265	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_003275	ENOG4108J1Q	
CO538_003290	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
CO538_003305	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
CO538_003325	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_003340	ENOG4108J1Q	
CO538_003355	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
CO538_003360	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
CO538_003380	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_003395	ENOG4108J1Q	
CO538_003400	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
CO538_003405	ENOG4105CI3	gtp-binding protein typa
CO538_003410	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
CO538_003425	ENOG4105FAV	ABC, transporter
CO538_003440	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
CO538_003495	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
CO538_003500	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
CO538_003510	ENOG41072GX	Peptidase M22 Glycoprotease
CO538_003520	ENOG4108J1Q	
CO538_003535	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CO538_003550	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_003555	ENOG4108J1Q	
CO538_003580	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
CO538_003595	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
CO538_003605	ENOG4105KNE	Phosphatidate cytidylyltransferase
CO538_003610	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
CO538_003620	ENOG4105C7S	Dehydrogenase
CO538_003625	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_003645	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
CO538_003660	ENOG4105C3G	gtp-binding protein
CO538_003670	ENOG4105CBT	Fructose-1,6-bisphosphatase
CO538_003685	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
CO538_003690	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
CO538_003705	ENOG4105C8N	cysteinyl-tRNA synthetase
CO538_003725	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
CO538_003730	ENOG4105BZ9	Cytochrome C oxidase, subunit I
CO538_003745	ENOG4108YXA	Membrane
CO538_003750	ENOG4108JYK	Dehydrogenase
CO538_003755	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
CO538_003770	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
CO538_003775	ENOG4107QN2	dihydrolipoyl dehydrogenase
CO538_003785	ENOG4108KAG	Cytochrome C oxidase, subunit I
CO538_003795	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
CO538_003810	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
CO538_003825	ENOG4108J1Q	
CO538_003835	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_003855	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
CO538_003870	ENOG4108J1Q	
CO538_003880	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
CO538_003900	ENOG4108J1Q	
CO538_003905	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_003930	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
CO538_003955	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_003980	ENOG4108J1Q	
CO538_004005	ENOG4108J1Q	
CO538_004010	ENOG4108Z03	MAF-like protein
CO538_004025	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
CO538_004035	ENOG4108J1Q	
CO538_004040	ENOG4105CAS	nag kinase
CO538_004045	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
CO538_004050	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
CO538_004075	ENOG4108J1Q	
CO538_004085	ENOG4105C2C	drug resistance transporter, Bcr CflA
CO538_004100	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_004110	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
CO538_004115	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_004125	ENOG4108J1Q	
CO538_004140	ENOG4105CNU	cell division protein FtsK
CO538_004180	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CO538_004185	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
CO538_004200	ENOG4108R6F	Surfeit locus 1 family protein
CO538_004205	ENOG4108UQY	Iron-storage protein
CO538_004230	ENOG4108J1Q	
CO538_004240	ENOG4105C9Q	fumarate hydratase class II
CO538_004255	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
CO538_004260	ENOG4108J1Q	
CO538_004275	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
CO538_004290	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
CO538_004295	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
CO538_004310	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
CO538_004320	ENOG4105WVQ	Fe-S assembly protein IscX
CO538_004330	ENOG4105KDC	50s ribosomal protein l28
CO538_004335	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
CO538_004345	ENOG4108JDX	DNA polymerase iii, epsilon subunit
CO538_004370	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_004395	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
CO538_004415	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
CO538_004425	ENOG4105CPP	Dehydrogenase, E1 component
CO538_004435	ENOG4105C3F	Signal peptidase i
CO538_004450	ENOG4108Z4V	iron-sulfur cluster assembly
CO538_004455	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
CO538_004460	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
CO538_004485	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
CO538_004490	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
CO538_004495	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
CO538_004505	ENOG4108J1Q	
CO538_004510	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_004525	ENOG4105CSH	Transporter
CO538_004535	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
CO538_004545	ENOG4108J1Q	
CO538_004560	ENOG4108EHY	type IV secretion system
CO538_004575	ENOG4108V42	Type IV secretion system protein VirB8
CO538_004580	ENOG4107QJN	gtp cyclohydrolase ii
CO538_004600	ENOG4105DHP	deoxycytidine triphosphate deaminase
CO538_004605	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
CO538_004620	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
CO538_004625	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
CO538_004630	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
CO538_004635	ENOG4105CE9	30S ribosomal protein S2
CO538_004680	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
CO538_004690	ENOG4108Z6B	deaminase
CO538_004700	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
CO538_004705	ENOG4105C75	arginyL-tRNA synthetase
CO538_004720	ENOG4105BZ1	(ABC) transporter
CO538_004730	ENOG4105C2C	drug resistance transporter, Bcr CflA
CO538_004765	ENOG4105M2J	Glutaredoxin
CO538_004775	ENOG4105C6K	Malic enzyme
CO538_004780	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
CO538_004795	ENOG4105CDY	transcriptional regulatory protein
CO538_004800	ENOG4105DR5	peptidase
CO538_004835	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
CO538_004840	ENOG4105W5Q	DNA repair protein (RadC
CO538_004930	ENOG4108J1Q	
CO538_004950	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
CO538_004955	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
CO538_004960	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
CO538_004970	ENOG41082FP	UPF0102 protein
CO538_004975	ENOG4108ZT0	50S ribosomal protein l17
CO538_004980	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
CO538_004985	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
CO538_004990	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CO538_004995	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
CO538_005000	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
CO538_005005	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
CO538_005010	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
CO538_005015	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
CO538_005020	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
CO538_005025	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
CO538_005030	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
CO538_005035	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CO538_005040	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
CO538_005045	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
CO538_005050	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
CO538_005060	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
CO538_005065	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
CO538_005070	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
CO538_005075	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
CO538_005080	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CO538_005085	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
CO538_005090	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
CO538_005095	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
CO538_005100	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
CO538_005105	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
CO538_005120	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
CO538_005130	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
CO538_005145	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_005160	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
CO538_005165	ENOG4105K46	50S ribosomal protein l27
CO538_005175	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
CO538_005180	ENOG4105ETU	transcriptional activator (TenA
CO538_005195	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
CO538_005200	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
CO538_005205	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
CO538_005230	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_005245	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
CO538_005255	ENOG4105C8U	phosphate abc transporter
CO538_005260	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
CO538_005265	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
CO538_005280	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_005300	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
CO538_005305	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
CO538_005315	ENOG4108R6K	riboflavin synthase, subunit alpha
CO538_005325	ENOG4107QKV	phosphomannomutase
CO538_005360	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_005375	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
CO538_005380	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
CO538_005400	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
CO538_005405	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
CO538_005410	ENOG4105BZG	amino acid carrier protein
CO538_005415	ENOG4105BZG	amino acid carrier protein
CO538_005420	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
CO538_005430	ENOG4105PGM	cation diffusion facilitator family transporter
CO538_005450	ENOG4108J1Q	
CO538_005455	ENOG4105C2N	RNA methyltransferase TrmH family group 3
CO538_005465	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
CO538_005470	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
CO538_005475	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
CO538_005500	ENOG4105D52	delta-aminolevulinic acid dehydratase
CO538_005505	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
CO538_005520	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
CO538_005535	ENOG4108I0Z	Aconitate hydratase
CO538_005540	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
CO538_005565	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_005580	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
CO538_005585	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
CO538_005600	ENOG4105EIE	fructose-bisphosphate aldolase
CO538_005610	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
CO538_005615	ENOG4105C1J	atp-dependent rna helicase
CO538_005625	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
CO538_005630	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
CO538_005645	ENOG4105D60	lipoprotein releasing system transmembrane protein
CO538_005700	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
CO538_005705	ENOG4105MKQ	Monovalent cation H antiporter subunit C
CO538_005715	ENOG4105C8S	subunit m
CO538_005730	ENOG41067UH	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
CO538_005740	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
CO538_005755	ENOG4107RIZ	hflk protein
CO538_005760	ENOG4105EPW	hflc protein
CO538_005780	ENOG4108J1Q	
CO538_005790	ENOG4108J1Q	
CO538_005880	ENOG4108J1Q	
CO538_005885	ENOG4105CP7	Triose-phosphate isomerase
CO538_005895	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
CO538_005900	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
CO538_005905	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
CO538_005915	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
CO538_005920	ENOG4105K5M	30s ribosomal protein S16
CO538_005925	ENOG4105EAH	synthase
CO538_005930	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CO538_005940	ENOG4108J1Q	
CO538_005965	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
CO538_005975	ENOG4108J1Q	
CO538_006005	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
CO538_006025	ENOG4108J1Q	
CO538_006040	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
CO538_006045	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
CO538_006065	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
CO538_006080	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
CO538_006085	ENOG4105DTN	riboflavin biosynthesis protein ribF
CO538_006100	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
CO538_006115	ENOG4105EE5	Membrane protein terC
CO538_006120	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
CO538_006145	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_006155	ENOG41060IM	Heme exporter protein
CO538_006160	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
CO538_006165	ENOG41087N0	50S ribosomal protein L36
CO538_006185	ENOG4105CB5	ATP-dependent DNA helicase recG
CO538_006195	ENOG4108J1Q	
CO538_006215	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_006230	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
CO538_006240	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_006250	ENOG4108J1Q	
CO538_006280	ENOG4105D4A	Cell wall formation (By similarity)
CO538_006285	ENOG4105CK2	sodium dicarboxylate symporter
CO538_006290	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
CO538_006300	ENOG4108J1Q	
CO538_006310	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
CO538_006320	ENOG4108J1Q	
CO538_006335	ENOG4108J1Q	
CO538_006345	ENOG4105CPF	Cell wall formation (By similarity)
CO538_006360	ENOG4108Z4U	Ferredoxin
CO538_006365	ENOG4105C79	DNA protecting protein DprA
CO538_006375	ENOG4108J1Q	
CO538_006385	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
CO538_006410	ENOG4105DZ1	carboxypeptidase
CO538_006415	ENOG4105W5Q	DNA repair protein (RadC
CO538_006430	ENOG4105DA4	cytochrome c-type biogenesis protein
CO538_006440	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
CO538_006450	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_006465	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_006475	ENOG4105CJW	magnesium transporter
CO538_006500	ENOG4105CSH	Transporter
CO538_006520	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_006535	ENOG4105C9M	aspartyl-trna synthetase
CO538_006550	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_006570	ENOG4105CSH	Transporter
CO538_006595	ENOG4105CJW	magnesium transporter
CO538_006605	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_006670	ENOG4108J1Q	
CO538_006685	ENOG4105W5Q	DNA repair protein (RadC
CO538_006715	ENOG4108J1Q	
CO538_006735	ENOG4107QIZ	NADH dehydrogenase
CO538_006740	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
CO538_006745	ENOG4105C22	threonyL-tRNA synthetase
CO538_006755	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
CO538_006770	ENOG4105CAY	ferredoxin--nadp reductase
CO538_006790	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
CO538_006810	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
CO538_006815	ENOG4107QPR	SAICAR synthetase
CO538_006820	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
CO538_006825	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
CO538_006830	ENOG4105E2Z	phosphate ABC transporter (Permease
CO538_006835	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
CO538_006840	ENOG4108J1Q	
CO538_006845	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
CO538_006850	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
CO538_006885	ENOG4105D1F	ATP-binding protein
CO538_006900	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_006915	ENOG4108J1Q	
CO538_006935	ENOG4108JPZ	Monovalent cation H antiporter subunit D
CO538_006940	ENOG4105CNI	cell division protein FtsW
CO538_006945	ENOG4105C3J	Cysteine desulfurase
CO538_006955	ENOG4108J1Q	
CO538_006975	ENOG4105EKQ	RNA-directed DNA polymerase
CO538_006985	ENOG4105W5Q	DNA repair protein (RadC
CO538_006990	ENOG41061P8	Persistence to inhibition of murein or DNA biosynthesis regulatory protein
CO538_007005	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
CO538_007010	ENOG4108IAJ	Nad-dependent epimerase dehydratase
CO538_007030	ENOG4105BZ1	(ABC) transporter
CO538_007080	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
CO538_007085	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
CO538_007110	ENOG4107XYW	BioY family
CO538_007115	ENOG4108RCM	Nitroreductase
CO538_007125	ENOG4105EKQ	RNA-directed DNA polymerase