locus-tag	class	description
K1Y75_00005	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K1Y75_00010	COG0436	Aminotransferase
K1Y75_00030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K1Y75_00035	COG0126	phosphoglycerate kinase activity
K1Y75_00050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K1Y75_00055	COG1185	polyribonucleotide nucleotidyltransferase activity
K1Y75_00060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K1Y75_00065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K1Y75_00070	COG2801	Transposase and inactivated derivatives
K1Y75_00085	COG3344	reverse transcriptase
K1Y75_00095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K1Y75_00095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K1Y75_00100	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K1Y75_00105	COG0316	Belongs to the HesB IscA family
K1Y75_00115	COG2945	thiolester hydrolase activity
K1Y75_00120	COG1104	cysteine desulfurase activity
K1Y75_00125	COG0670	Belongs to the BI1 family
K1Y75_00130	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K1Y75_00145	COG3344	reverse transcriptase
K1Y75_00160	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K1Y75_00170	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K1Y75_00195	COG0629	single-stranded DNA binding
K1Y75_00200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K1Y75_00215	COG3344	reverse transcriptase
K1Y75_00235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K1Y75_00265	COG2801	Transposase and inactivated derivatives
K1Y75_00275	COG2801	Transposase and inactivated derivatives
K1Y75_00280	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K1Y75_00285	COG0799	negative regulation of ribosome biogenesis
K1Y75_00295	COG1012	belongs to the aldehyde dehydrogenase family
K1Y75_00305	COG0494	nUDIX hydrolase
K1Y75_00310	COG0084	hydrolase, TatD family'
K1Y75_00315	COG0039	L-malate dehydrogenase activity
K1Y75_00320	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K1Y75_00325	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K1Y75_00330	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K1Y75_00335	COG0537	adenosine 5'-monophosphoramidase activity
K1Y75_00355	COG1090	epimerase
K1Y75_00365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K1Y75_00370	COG0416	fatty acid biosynthetic process
K1Y75_00375	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K1Y75_00380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K1Y75_00385	COG1127	ABC transporter
K1Y75_00390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K1Y75_00405	COG0493	'glutamate synthase
K1Y75_00405	COG0543	2 iron, 2 sulfur cluster binding
K1Y75_00410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K1Y75_00425	COG0750	zinc metalloprotease
K1Y75_00440	COG0776	regulation of translation
K1Y75_00445	COG0539	negative regulation of cytoplasmic translation
K1Y75_00450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K1Y75_00470	COG2801	Transposase and inactivated derivatives
K1Y75_00490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K1Y75_00495	COG0045	succinate-CoA ligase (ADP-forming) activity
K1Y75_00510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K1Y75_00540	COG1475	DNA binding
K1Y75_00545	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K1Y75_00545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K1Y75_00555	COG3344	reverse transcriptase
K1Y75_00565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K1Y75_00570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K1Y75_00580	COG0156	8-amino-7-oxononanoate synthase activity
K1Y75_00590	COG0326	Molecular chaperone. Has ATPase activity
K1Y75_00605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K1Y75_00630	COG0666	response to abiotic stimulus
K1Y75_00635	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K1Y75_00640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K1Y75_00645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K1Y75_00650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K1Y75_00655	COG0142	geranyltranstransferase activity
K1Y75_00665	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K1Y75_00670	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K1Y75_00685	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K1Y75_00695	COG0105	UTP biosynthetic process
K1Y75_00700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K1Y75_00705	COG4536	flavin adenine dinucleotide binding
K1Y75_00710	COG3750	Belongs to the UPF0335 family
K1Y75_00715	COG0163	prenyltransferase activity
K1Y75_00720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K1Y75_00735	COG0495	leucyl-tRNA aminoacylation
K1Y75_00750	COG0776	regulation of translation
K1Y75_00795	COG2801	Transposase and inactivated derivatives
K1Y75_00835	COG3344	reverse transcriptase
K1Y75_00850	COG0321	lipoyl(octanoyl) transferase activity
K1Y75_00870	COG0360	Binds together with S18 to 16S ribosomal RNA
K1Y75_00880	COG0359	binds to the 23S rRNA
K1Y75_00885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K1Y75_00900	COG2801	Transposase and inactivated derivatives
K1Y75_00915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K1Y75_00960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K1Y75_00960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K1Y75_00970	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
K1Y75_00980	COG2801	Transposase and inactivated derivatives
K1Y75_01015	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K1Y75_01030	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K1Y75_01055	COG3344	reverse transcriptase
K1Y75_01070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K1Y75_01075	COG2857	Cytochrome c1
K1Y75_01075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K1Y75_01080	COG0556	nucleotide-excision repair
K1Y75_01085	COG2801	Transposase and inactivated derivatives
K1Y75_01100	COG0484	heat shock protein binding
K1Y75_01110	COG0124	histidyl-tRNA synthetase
K1Y75_01115	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K1Y75_01125	COG0531	amino acid
K1Y75_01130	COG1113	amino acid transport
K1Y75_01140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K1Y75_01145	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K1Y75_01155	COG1178	ABC-type Fe3 transport system permease component
K1Y75_01160	COG1054	Belongs to the UPF0176 family
K1Y75_01200	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K1Y75_01210	COG3451	type IV secretory pathway VirB4
K1Y75_01215	COG3704	protein secretion by the type IV secretion system
K1Y75_01220	COG3704	protein secretion by the type IV secretion system
K1Y75_01225	COG3704	protein secretion by the type IV secretion system
K1Y75_01225	COG1340	protein secretion by the type IV secretion system
K1Y75_01245	COG2801	Transposase and inactivated derivatives
K1Y75_01265	COG3344	reverse transcriptase
K1Y75_01275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K1Y75_01280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K1Y75_01290	COG0072	phenylalanine-tRNA ligase activity
K1Y75_01290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K1Y75_01300	COG0356	it plays a direct role in the translocation of protons across the membrane
K1Y75_01305	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K1Y75_01325	COG1612	heme a metabolic process
K1Y75_01330	COG4770	biotin carboxylase activity
K1Y75_01340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K1Y75_01345	COG0071	Belongs to the small heat shock protein (HSP20) family
K1Y75_01350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K1Y75_01365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K1Y75_01375	COG3827	peptidoglycan binding
K1Y75_01380	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K1Y75_01400	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K1Y75_01405	COG0343	queuine tRNA-ribosyltransferase activity
K1Y75_01415	COG0612	Peptidase, M16
K1Y75_01420	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K1Y75_01460	COG0445	tRNA wobble uridine modification
K1Y75_01500	COG3451	type IV secretory pathway VirB4
K1Y75_01515	COG2070	2-Nitropropane dioxygenase
K1Y75_01525	COG0649	NAD binding
K1Y75_01535	COG3344	reverse transcriptase
K1Y75_01545	COG2801	Transposase and inactivated derivatives
K1Y75_01555	COG2801	Transposase and inactivated derivatives
K1Y75_01570	COG0745	RESPONSE REGULATOR receiver
K1Y75_01575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K1Y75_01580	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K1Y75_01595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K1Y75_01600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K1Y75_01635	COG0726	polysaccharide deacetylase
K1Y75_01640	COG0768	penicillin binding
K1Y75_01645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K1Y75_01650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K1Y75_01655	COG0740	serine-type endopeptidase activity
K1Y75_01660	COG0544	peptidyl-prolyl cis-trans isomerase activity
K1Y75_01680	COG2890	protein-(glutamine-N5) methyltransferase activity
K1Y75_01680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K1Y75_01685	COG3344	reverse transcriptase
K1Y75_01695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K1Y75_01700	COG0049	tRNA binding
K1Y75_01705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K1Y75_01710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K1Y75_01725	COG0250	Participates in transcription elongation, termination and antitermination
K1Y75_01730	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K1Y75_01735	COG0081	regulation of translation
K1Y75_01740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K1Y75_01745	COG0222	ribosome binding
K1Y75_01750	COG0085	RNA polymerase activity
K1Y75_01750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K1Y75_01765	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K1Y75_01770	COG0151	Belongs to the GarS family
K1Y75_01780	COG0473	3-isopropylmalate dehydrogenase activity
K1Y75_01825	COG3344	reverse transcriptase
K1Y75_01855	COG2801	Transposase and inactivated derivatives
K1Y75_01875	COG2171	N-acyltransferase activity
K1Y75_01885	COG1053	succinate dehydrogenase
K1Y75_01895	COG0194	GDP metabolic process
K1Y75_01910	COG0540	Belongs to the ATCase OTCase family
K1Y75_01915	COG1840	ABC-type Fe3 transport system, periplasmic component
K1Y75_01925	COG2801	Transposase and inactivated derivatives
K1Y75_01935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K1Y75_01940	COG0254	rRNA binding
K1Y75_01945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K1Y75_01955	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K1Y75_01970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K1Y75_01990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K1Y75_01995	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K1Y75_02000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K1Y75_02015	COG2801	Transposase and inactivated derivatives
K1Y75_02025	COG2801	Transposase and inactivated derivatives
K1Y75_02050	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K1Y75_02055	COG2801	Transposase and inactivated derivatives
K1Y75_02065	COG0285	dihydrofolate synthase activity
K1Y75_02080	COG2867	negative regulation of translational initiation
K1Y75_02115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K1Y75_02120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K1Y75_02130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K1Y75_02145	COG0101	tRNA pseudouridine synthase activity
K1Y75_02150	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K1Y75_02165	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K1Y75_02180	COG0275	rRNA processing
K1Y75_02185	COG0477	Major facilitator Superfamily
K1Y75_02190	COG0024	Methionine aminopeptidase
K1Y75_02195	COG0849	cell division
K1Y75_02200	COG0242	peptide deformylase activity
K1Y75_02205	COG1573	uracil-dna glycosylase
K1Y75_02210	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
K1Y75_02220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K1Y75_02235	COG1295	ribonuclease BN
K1Y75_02240	COG1028	Short-chain dehydrogenase reductase Sdr
K1Y75_02245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K1Y75_02255	COG0564	pseudouridine synthase activity
K1Y75_02265	COG0658	competence protein
K1Y75_02265	COG2333	competence protein COMEC
K1Y75_02285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K1Y75_02305	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K1Y75_02310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K1Y75_02320	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K1Y75_02330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K1Y75_02350	COG3344	reverse transcriptase
K1Y75_02360	COG2801	Transposase and inactivated derivatives
K1Y75_02375	COG0493	'glutamate synthase
K1Y75_02375	COG0543	2 iron, 2 sulfur cluster binding
K1Y75_02380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K1Y75_02390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K1Y75_02400	COG0482	sulfurtransferase activity
K1Y75_02415	COG2885	chlorophyll binding
K1Y75_02420	COG0037	tRNA processing
K1Y75_02425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K1Y75_02430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K1Y75_02440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K1Y75_02465	COG0508	dehydrogenase complex catalyzes the overall conversion of
K1Y75_02505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K1Y75_02515	COG2205	protein histidine kinase activity
K1Y75_02520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K1Y75_02535	COG3344	reverse transcriptase
K1Y75_02550	COG0628	permease
K1Y75_02560	COG4974	Belongs to the 'phage' integrase family
K1Y75_02570	COG0268	Binds directly to 16S ribosomal RNA
K1Y75_02575	COG0372	Belongs to the citrate synthase family
K1Y75_02605	COG2255	four-way junction helicase activity
K1Y75_02610	COG0632	four-way junction helicase activity
K1Y75_02615	COG3474	cytochrome
K1Y75_02635	COG0839	Belongs to the complex I subunit 6 family
K1Y75_02640	COG0713	ATP synthesis coupled electron transport
K1Y75_02645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K1Y75_02650	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K1Y75_02655	COG1007	ATP synthesis coupled electron transport
K1Y75_02665	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K1Y75_02670	COG2801	Transposase and inactivated derivatives
K1Y75_02700	COG2801	Transposase and inactivated derivatives
K1Y75_02735	COG3344	reverse transcriptase
K1Y75_02760	COG0542	response to heat
K1Y75_02765	COG2902	Dehydrogenase
K1Y75_02780	COG1381	Involved in DNA repair and RecF pathway recombination
K1Y75_02805	COG2801	Transposase and inactivated derivatives
K1Y75_02810	COG2801	Transposase and inactivated derivatives
K1Y75_02850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K1Y75_02855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K1Y75_02870	COG2801	Transposase and inactivated derivatives
K1Y75_02885	COG0174	glutamine synthetase
K1Y75_02890	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K1Y75_02905	COG3577	Aspartyl protease
K1Y75_02930	COG0756	dUTP diphosphatase activity
K1Y75_02940	COG3344	reverse transcriptase
K1Y75_02950	COG0450	alkyl hydroperoxide reductase
K1Y75_02960	COG2801	Transposase and inactivated derivatives
K1Y75_02965	COG3344	reverse transcriptase
K1Y75_03005	COG3344	reverse transcriptase
K1Y75_03020	COG2801	Transposase and inactivated derivatives
K1Y75_03025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K1Y75_03030	COG1121	(ABC) transporter
K1Y75_03045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K1Y75_03050	COG1530	ribonuclease E activity
K1Y75_03060	COG0271	Belongs to the BolA IbaG family
K1Y75_03065	COG0626	cystathionine gamma-synthase activity
K1Y75_03075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K1Y75_03085	COG0009	L-threonylcarbamoyladenylate synthase
K1Y75_03110	COG0305	Participates in initiation and elongation during chromosome replication
K1Y75_03120	COG1714	RDD family
K1Y75_03130	COG2801	Transposase and inactivated derivatives
K1Y75_03145	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K1Y75_03150	COG0237	dephospho-CoA kinase activity
K1Y75_03160	COG3344	reverse transcriptase
K1Y75_03165	COG3344	reverse transcriptase
K1Y75_03175	COG3344	reverse transcriptase
K1Y75_03185	COG2801	Transposase and inactivated derivatives
K1Y75_03195	COG0666	response to abiotic stimulus
K1Y75_03200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K1Y75_03215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K1Y75_03225	COG2801	Transposase and inactivated derivatives
K1Y75_03240	COG3344	reverse transcriptase
K1Y75_03255	COG2801	Transposase and inactivated derivatives
K1Y75_03270	COG0805	protein transport
K1Y75_03295	COG3344	reverse transcriptase
K1Y75_03310	COG2801	Transposase and inactivated derivatives
K1Y75_03315	COG0617	tRNA 3'-terminal CCA addition
K1Y75_03320	COG1217	gtp-binding protein TYPA
K1Y75_03325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K1Y75_03325	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K1Y75_03340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K1Y75_03355	COG1074	ATP-dependent DNA helicase activity
K1Y75_03410	COG0358	DNA primase activity
K1Y75_03415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K1Y75_03435	COG2801	Transposase and inactivated derivatives
K1Y75_03465	COG3344	reverse transcriptase
K1Y75_03470	COG2801	Transposase and inactivated derivatives
K1Y75_03485	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K1Y75_03495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K1Y75_03510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K1Y75_03520	COG0575	Belongs to the CDS family
K1Y75_03525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K1Y75_03535	COG0508	dehydrogenase complex catalyzes the overall conversion of
K1Y75_03540	COG3344	reverse transcriptase
K1Y75_03555	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K1Y75_03570	COG0012	GTP binding
K1Y75_03580	COG1494	fructose-1,6-bisphosphatase
K1Y75_03595	COG3842	ATPase activity
K1Y75_03600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K1Y75_03610	COG3932	Exopolysaccharide synthesis, ExoD
K1Y75_03615	COG0215	cysteine-tRNA ligase activity
K1Y75_03630	COG0109	protoheme IX farnesyltransferase activity
K1Y75_03635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K1Y75_03640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K1Y75_03645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K1Y75_03650	COG1981	membrane
K1Y75_03655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K1Y75_03660	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K1Y75_03675	COG4974	Belongs to the 'phage' integrase family
K1Y75_03690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K1Y75_03700	COG0525	valine-tRNA ligase activity
K1Y75_03715	COG0284	orotidine-5'-phosphate decarboxylase activity
K1Y75_03730	COG2801	Transposase and inactivated derivatives
K1Y75_03740	COG3344	reverse transcriptase
K1Y75_03760	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K1Y75_03775	COG2801	Transposase and inactivated derivatives
K1Y75_03780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K1Y75_03800	COG2801	Transposase and inactivated derivatives
K1Y75_03805	COG3344	reverse transcriptase
K1Y75_03815	COG2801	Transposase and inactivated derivatives
K1Y75_03830	COG0736	holo-[acyl-carrier-protein] synthase activity
K1Y75_03850	COG3344	reverse transcriptase
K1Y75_03875	COG2801	Transposase and inactivated derivatives
K1Y75_03885	COG1115	amino acid carrier protein
K1Y75_03895	COG2801	Transposase and inactivated derivatives
K1Y75_03900	COG0424	maF-like protein
K1Y75_03915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K1Y75_03925	COG2801	Transposase and inactivated derivatives
K1Y75_03930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K1Y75_03935	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K1Y75_03940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K1Y75_03965	COG2801	Transposase and inactivated derivatives
K1Y75_03975	COG2814	Major facilitator Superfamily
K1Y75_03990	COG3344	reverse transcriptase
K1Y75_04000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K1Y75_04005	COG3344	reverse transcriptase
K1Y75_04015	COG2801	Transposase and inactivated derivatives
K1Y75_04030	COG1674	ftsk spoiiie
K1Y75_04045	COG2801	Transposase and inactivated derivatives
K1Y75_04060	COG2801	Transposase and inactivated derivatives
K1Y75_04070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K1Y75_04075	COG0148	phosphopyruvate hydratase activity
K1Y75_04090	COG3346	SURF1 family
K1Y75_04120	COG2801	Transposase and inactivated derivatives
K1Y75_04130	COG0114	fumarate hydratase activity
K1Y75_04145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K1Y75_04150	COG2801	Transposase and inactivated derivatives
K1Y75_04165	COG0484	heat shock protein binding
K1Y75_04175	COG0823	Involved in the tonB-independent uptake of proteins
K1Y75_04180	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K1Y75_04185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K1Y75_04190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K1Y75_04195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K1Y75_04215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K1Y75_04220	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K1Y75_04235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K1Y75_04260	COG3344	reverse transcriptase
K1Y75_04285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K1Y75_04305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K1Y75_04315	COG0022	dehydrogenase e1 component
K1Y75_04315	COG0508	dehydrogenase complex catalyzes the overall conversion of
K1Y75_04325	COG0681	Belongs to the peptidase S26 family
K1Y75_04340	COG0316	Belongs to the HesB IscA family
K1Y75_04345	COG0822	iron-sulfur transferase activity
K1Y75_04350	COG0552	protein localization to endoplasmic reticulum
K1Y75_04380	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K1Y75_04385	COG0459	protein refolding
K1Y75_04395	COG2801	Transposase and inactivated derivatives
K1Y75_04400	COG3344	reverse transcriptase
K1Y75_04410	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K1Y75_04415	COG0477	Major facilitator Superfamily
K1Y75_04420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K1Y75_04430	COG2801	Transposase and inactivated derivatives
K1Y75_04445	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
K1Y75_04460	COG3736	Type IV secretory pathway, component VirB8
K1Y75_04485	COG0717	Belongs to the dCTP deaminase family
K1Y75_04490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K1Y75_04505	COG0233	cytoplasmic translational termination
K1Y75_04510	COG0528	UMP kinase activity
K1Y75_04515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K1Y75_04520	COG0052	Belongs to the universal ribosomal protein uS2 family
K1Y75_04530	COG1862	Preprotein translocase
K1Y75_04555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K1Y75_04555	COG4451	ribulose bisphosphate carboxylase, small
K1Y75_04565	COG0504	CTP synthase activity
K1Y75_04575	COG0590	tRNA wobble adenosine to inosine editing
K1Y75_04585	COG4133	protoheme IX ABC transporter activity
K1Y75_04590	COG0018	arginyl-trna synthetase
K1Y75_04605	COG1132	(ABC) transporter
K1Y75_04615	COG2814	Major facilitator Superfamily
K1Y75_04650	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K1Y75_04660	COG0280	phosphate acetyltransferase
K1Y75_04660	COG0281	malic enzyme
K1Y75_04665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K1Y75_04680	COG0217	transcriptional regulatory protein
K1Y75_04685	COG0739	heme binding
K1Y75_04720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K1Y75_04720	COG0574	Belongs to the PEP-utilizing enzyme family
K1Y75_04725	COG2003	Belongs to the UPF0758 family
K1Y75_04810	COG2801	Transposase and inactivated derivatives
K1Y75_04830	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K1Y75_04830	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K1Y75_04835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K1Y75_04840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K1Y75_04845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K1Y75_04850	COG0792	nuclease activity
K1Y75_04855	COG0203	ribosomal protein L17
K1Y75_04860	COG0202	RNA polymerase activity
K1Y75_04865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K1Y75_04870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K1Y75_04875	COG0563	adenylate kinase activity
K1Y75_04880	COG0201	protein transport
K1Y75_04885	COG0200	Binds to the 23S rRNA
K1Y75_04890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K1Y75_04895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K1Y75_04900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K1Y75_04905	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K1Y75_04910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K1Y75_04915	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K1Y75_04920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K1Y75_04925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K1Y75_04935	COG0255	Belongs to the universal ribosomal protein uL29 family
K1Y75_04940	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K1Y75_04945	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K1Y75_04950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K1Y75_04955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K1Y75_04960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K1Y75_04970	COG0088	Forms part of the polypeptide exit tunnel
K1Y75_04975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K1Y75_04980	COG0051	transcription antitermination factor activity, RNA binding
K1Y75_04985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K1Y75_05025	COG3344	reverse transcriptase
K1Y75_05040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K1Y75_05045	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K1Y75_05055	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K1Y75_05060	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K1Y75_05070	COG1845	cytochrome c oxidase, subunit III
K1Y75_05075	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K1Y75_05080	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K1Y75_05085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K1Y75_05085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K1Y75_05110	COG3344	reverse transcriptase
K1Y75_05125	COG0594	ribonuclease P activity
K1Y75_05130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K1Y75_05135	COG0573	inorganic phosphate transmembrane transporter activity
K1Y75_05140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K1Y75_05145	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K1Y75_05160	COG3344	reverse transcriptase
K1Y75_05180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K1Y75_05185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K1Y75_05195	COG0307	riboflavin synthase, alpha
K1Y75_05205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K1Y75_05235	COG3344	reverse transcriptase
K1Y75_05245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K1Y75_05245	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K1Y75_05250	COG0154	amidase activity
K1Y75_05255	COG0187	DNA topoisomerase II activity
K1Y75_05280	COG1183	phosphatidylcholine synthase activity
K1Y75_05285	COG1115	amino acid carrier protein
K1Y75_05290	COG1115	amino acid carrier protein
K1Y75_05295	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K1Y75_05305	COG1230	cation diffusion facilitator family transporter
K1Y75_05320	COG2801	Transposase and inactivated derivatives
K1Y75_05325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K1Y75_05335	COG0322	excinuclease ABC activity
K1Y75_05340	COG0751	glycine-tRNA ligase activity
K1Y75_05345	COG0752	glycyl-tRNA synthetase alpha subunit
K1Y75_05365	COG2801	Transposase and inactivated derivatives
K1Y75_05370	COG0113	porphobilinogen synthase activity
K1Y75_05375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K1Y75_05380	COG1034	ATP synthesis coupled electron transport
K1Y75_05395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K1Y75_05410	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K1Y75_05415	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K1Y75_05425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K1Y75_05440	COG3344	reverse transcriptase
K1Y75_05455	COG0571	ribonuclease III activity
K1Y75_05460	COG0167	dihydroorotate dehydrogenase activity
K1Y75_05475	COG1830	Aldolase
K1Y75_05485	COG0542	response to heat
K1Y75_05490	COG0513	Belongs to the DEAD box helicase family
K1Y75_05495	COG1278	Cold shock
K1Y75_05500	COG0312	modulator of DNA gyrase
K1Y75_05505	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K1Y75_05520	COG4591	ABC-type transport system involved in lipoprotein release permease component
K1Y75_05545	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K1Y75_05550	COG2009	succinate dehydrogenase
K1Y75_05575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K1Y75_05580	COG1006	Multisubunit Na H antiporter MnhC subunit
K1Y75_05590	COG2111	Na H antiporter
K1Y75_05590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K1Y75_05605	COG1758	RNA polymerase activity
K1Y75_05615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K1Y75_05630	COG0330	HflC and HflK could
K1Y75_05650	COG2801	Transposase and inactivated derivatives
K1Y75_05655	COG2801	Transposase and inactivated derivatives
K1Y75_05745	COG2801	Transposase and inactivated derivatives
K1Y75_05750	COG0149	triose-phosphate isomerase activity
K1Y75_05760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K1Y75_05770	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K1Y75_05780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K1Y75_05785	COG0228	four-way junction DNA binding
K1Y75_05790	COG0142	geranyltranstransferase activity
K1Y75_05795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K1Y75_05805	COG2801	Transposase and inactivated derivatives
K1Y75_05825	COG2801	Transposase and inactivated derivatives
K1Y75_05830	COG0567	Dehydrogenase, E1 component
K1Y75_05840	COG2801	Transposase and inactivated derivatives
K1Y75_05870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K1Y75_05890	COG2801	Transposase and inactivated derivatives
K1Y75_05905	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K1Y75_05910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K1Y75_05930	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K1Y75_05940	COG0612	Peptidase, M16
K1Y75_05945	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K1Y75_05950	COG0196	riboflavin kinase activity
K1Y75_05965	COG0481	GTPase activity
K1Y75_05980	COG1253	flavin adenine dinucleotide binding
K1Y75_05985	COG0519	Catalyzes the synthesis of GMP from XMP
K1Y75_05985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K1Y75_05990	COG1450	Type ii and iii secretion system protein
K1Y75_06010	COG3344	reverse transcriptase
K1Y75_06020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K1Y75_06025	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K1Y75_06030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K1Y75_06045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K1Y75_06055	COG2801	Transposase and inactivated derivatives
K1Y75_06075	COG3344	reverse transcriptase
K1Y75_06085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K1Y75_06095	COG3344	reverse transcriptase
K1Y75_06105	COG2801	Transposase and inactivated derivatives
K1Y75_06115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K1Y75_06130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K1Y75_06135	COG1301	dicarboxylic acid transport
K1Y75_06140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K1Y75_06150	COG2801	Transposase and inactivated derivatives
K1Y75_06160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K1Y75_06175	COG2801	Transposase and inactivated derivatives
K1Y75_06190	COG2801	Transposase and inactivated derivatives
K1Y75_06200	COG1181	Belongs to the D-alanine--D-alanine ligase family
K1Y75_06210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K1Y75_06215	COG0758	DNA mediated transformation
K1Y75_06230	COG2801	Transposase and inactivated derivatives
K1Y75_06235	COG3335	DDE superfamily endonuclease
K1Y75_06240	COG0653	protein targeting
K1Y75_06260	COG1322	Protein conserved in bacteria
K1Y75_06265	COG1686	Belongs to the peptidase S11 family
K1Y75_06270	COG2003	Belongs to the UPF0758 family
K1Y75_06285	COG1138	Cytochrome C-type biogenesis protein
K1Y75_06295	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K1Y75_06300	COG3344	reverse transcriptase
K1Y75_06315	COG3344	reverse transcriptase
K1Y75_06325	COG2239	Acts as a magnesium transporter
K1Y75_06345	COG0564	pseudouridine synthase activity
K1Y75_06365	COG3344	reverse transcriptase
K1Y75_06380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K1Y75_06395	COG3344	reverse transcriptase
K1Y75_06415	COG0564	pseudouridine synthase activity
K1Y75_06435	COG2239	Acts as a magnesium transporter
K1Y75_06445	COG3344	reverse transcriptase
K1Y75_06510	COG2801	Transposase and inactivated derivatives
K1Y75_06525	COG2003	Belongs to the UPF0758 family
K1Y75_06545	COG3621	Patatin-like phospholipase
K1Y75_06555	COG2801	Transposase and inactivated derivatives
K1Y75_06575	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K1Y75_06580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K1Y75_06585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K1Y75_06590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K1Y75_06605	COG0492	ferredoxin-NADP+ reductase activity
K1Y75_06625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K1Y75_06645	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K1Y75_06650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K1Y75_06655	COG0336	Belongs to the RNA methyltransferase TrmD family
K1Y75_06660	COG0335	large ribosomal subunit rRNA binding
K1Y75_06665	COG0581	inorganic phosphate transmembrane transporter activity
K1Y75_06670	COG0047	phosphoribosylformylglycinamidine synthase activity
K1Y75_06675	COG2801	Transposase and inactivated derivatives
K1Y75_06680	COG0259	pyridoxamine-phosphate oxidase activity
K1Y75_06685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K1Y75_06725	COG0489	protein tyrosine kinase activity
K1Y75_06740	COG3344	reverse transcriptase
K1Y75_06755	COG2801	Transposase and inactivated derivatives
K1Y75_06775	COG0651	ATP synthesis coupled electron transport
K1Y75_06780	COG0772	Belongs to the SEDS family
K1Y75_06785	COG1104	cysteine desulfurase activity
K1Y75_06795	COG2801	Transposase and inactivated derivatives
K1Y75_06810	COG3344	reverse transcriptase
K1Y75_06820	COG2003	Belongs to the UPF0758 family
K1Y75_06825	COG1396	sequence-specific DNA binding
K1Y75_06840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K1Y75_06845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K1Y75_06865	COG1132	(ABC) transporter
K1Y75_06890	COG0697	spore germination
K1Y75_06915	COG0312	modulator of DNA gyrase
K1Y75_06920	COG0723	plastoquinol--plastocyanin reductase activity
K1Y75_06945	COG1268	BioY protein
K1Y75_06960	COG3344	reverse transcriptase
K1Y75_06975	COG1253	flavin adenine dinucleotide binding