locus-tag	class	description
J5252_00030	COG1132	(ABC) transporter
J5252_00065	COG0697	spore germination
J5252_00120	COG2003	Belongs to the UPF0758 family
J5252_00130	COG0768	penicillin binding
J5252_00155	COG2171	N-acyltransferase activity
J5252_00165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J5252_00175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J5252_00175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J5252_00180	COG0232	Belongs to the dGTPase family. Type 2 subfamily
J5252_00185	COG0316	Belongs to the HesB IscA family
J5252_00200	COG2945	thiolester hydrolase activity
J5252_00205	COG1104	cysteine desulfurase activity
J5252_00220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J5252_00225	COG3547	Transposase (IS116 IS110 IS902 family)
J5252_00245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5252_00360	COG1396	sequence-specific DNA binding
J5252_00365	COG2003	Belongs to the UPF0758 family
J5252_00385	COG0697	spore germination
J5252_00410	COG1132	(ABC) transporter
J5252_00430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5252_00435	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J5252_00440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J5252_00470	COG2189	Belongs to the N(4) N(6)-methyltransferase family
J5252_00665	COG3621	Patatin-like phospholipase
J5252_00670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J5252_00925	COG1122	ATPase activity
J5252_00930	COG4120	Belongs to the binding-protein-dependent transport system permease family
J5252_00935	COG2984	ABC transporter substrate binding protein
J5252_00960	COG2963	transposase activity
J5252_00970	COG2801	Transposase and inactivated derivatives
J5252_00975	COG2801	Transposase and inactivated derivatives
J5252_00980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J5252_00985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J5252_00990	COG0109	protoheme IX farnesyltransferase activity
J5252_00995	COG0328	RNA-DNA hybrid ribonuclease activity
J5252_01005	COG0459	protein refolding
J5252_01010	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J5252_01015	COG0354	folic acid binding
J5252_01020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J5252_01030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J5252_01040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
J5252_01045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J5252_01055	COG0544	peptidyl-prolyl cis-trans isomerase activity
J5252_01085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5252_01130	COG1121	(ABC) transporter
J5252_01135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J5252_01190	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
J5252_01195	COG0670	Belongs to the BI1 family
J5252_01200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J5252_01210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J5252_01230	COG0531	amino acid
J5252_01245	COG0527	aspartate kinase activity
J5252_01275	COG0839	Belongs to the complex I subunit 6 family
J5252_01280	COG0713	ATP synthesis coupled electron transport
J5252_01285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J5252_01290	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5252_01295	COG1007	ATP synthesis coupled electron transport
J5252_01300	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J5252_01300	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J5252_01300	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J5252_01300	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J5252_01310	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J5252_01340	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J5252_01345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J5252_01350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J5252_01360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5252_01365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J5252_01375	COG0492	ferredoxin-NADP+ reductase activity
J5252_01385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J5252_01395	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J5252_01400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J5252_01405	COG1127	ABC transporter
J5252_01415	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J5252_01475	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J5252_01490	COG1674	ftsk spoiiie
J5252_01545	COG0307	riboflavin synthase, alpha
J5252_01555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J5252_01560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J5252_01565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J5252_01570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J5252_01580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J5252_01590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
J5252_01600	COG1845	cytochrome c oxidase, subunit III
J5252_01610	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J5252_01625	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J5252_01640	COG0215	cysteine-tRNA ligase activity
J5252_01645	COG3932	Exopolysaccharide synthesis, ExoD
J5252_01655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J5252_01660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J5252_01670	COG0322	excinuclease ABC activity
J5252_01680	COG0752	glycyl-tRNA synthetase alpha subunit
J5252_01690	COG0113	porphobilinogen synthase activity
J5252_01695	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J5252_01715	COG1573	uracil-dna glycosylase
J5252_01720	COG0242	peptide deformylase activity
J5252_01725	COG0849	cell division
J5252_01730	COG0024	Methionine aminopeptidase
J5252_01735	COG0477	Major facilitator Superfamily
J5252_01740	COG0275	rRNA processing
J5252_01760	COG0193	aminoacyl-tRNA hydrolase activity
J5252_01770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J5252_01780	COG0489	protein tyrosine kinase activity
J5252_01805	COG2801	Transposase and inactivated derivatives
J5252_01810	COG2801	Transposase and inactivated derivatives
J5252_01825	COG0237	dephospho-CoA kinase activity
J5252_01830	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
J5252_01835	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J5252_01850	COG1253	flavin adenine dinucleotide binding
J5252_01860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J5252_01860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J5252_01895	COG0573	inorganic phosphate transmembrane transporter activity
J5252_01900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J5252_01905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J5252_01915	COG2801	Transposase and inactivated derivatives
J5252_01930	COG0235	Class ii aldolase
J5252_01970	COG4804	nuclease activity
J5252_01980	COG1381	Involved in DNA repair and RecF pathway recombination
J5252_02000	COG2902	Dehydrogenase
J5252_02005	COG0542	response to heat
J5252_02020	COG1217	gtp-binding protein TYPA
J5252_02025	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J5252_02030	COG1301	dicarboxylic acid transport
J5252_02045	COG1138	Cytochrome C-type biogenesis protein
J5252_02060	COG3577	Aspartyl protease
J5252_02095	COG0756	dUTP diphosphatase activity
J5252_02100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J5252_02105	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J5252_02110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J5252_02115	COG2814	Major facilitator Superfamily
J5252_02140	COG2801	Transposase and inactivated derivatives
J5252_02145	COG1322	Protein conserved in bacteria
J5252_02160	COG0649	NAD binding
J5252_02165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J5252_02170	COG4536	flavin adenine dinucleotide binding
J5252_02175	COG3750	Belongs to the UPF0335 family
J5252_02180	COG0163	prenyltransferase activity
J5252_02185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J5252_02195	COG2801	Transposase and inactivated derivatives
J5252_02225	COG0653	protein targeting
J5252_02235	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5252_02245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J5252_02340	COG3344	reverse transcriptase
J5252_02355	COG1132	(ABC) transporter
J5252_02365	COG0018	arginyl-trna synthetase
J5252_02390	COG4133	protoheme IX ABC transporter activity
J5252_02405	COG0477	Major facilitator Superfamily
J5252_02410	COG0564	pseudouridine synthase activity
J5252_02415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J5252_02420	COG1981	membrane
J5252_02430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J5252_02440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J5252_02450	COG0072	phenylalanine-tRNA ligase activity
J5252_02450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5252_02460	COG0356	it plays a direct role in the translocation of protons across the membrane
J5252_02465	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J5252_02490	COG1612	heme a metabolic process
J5252_02495	COG4770	biotin carboxylase activity
J5252_02505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J5252_02510	COG1053	succinate dehydrogenase
J5252_02520	COG0194	GDP metabolic process
J5252_02540	COG0012	GTP binding
J5252_02550	COG0617	tRNA 3'-terminal CCA addition
J5252_02570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J5252_02575	COG0805	protein transport
J5252_02580	COG1438	arginine binding
J5252_02585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5252_02590	COG0765	amino acid transport
J5252_02595	COG1126	abc transporter atp-binding protein
J5252_02615	COG0284	orotidine-5'-phosphate decarboxylase activity
J5252_02630	COG0525	valine-tRNA ligase activity
J5252_02650	COG0504	CTP synthase activity
J5252_02655	COG0590	tRNA wobble adenosine to inosine editing
J5252_02660	COG0477	Major facilitator Superfamily
J5252_02670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J5252_02675	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5252_02675	COG0022	dehydrogenase e1 component
J5252_02685	COG0481	GTPase activity
J5252_02710	COG0739	heme binding
J5252_02715	COG0217	transcriptional regulatory protein
J5252_02720	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J5252_02730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J5252_02735	COG0280	phosphate acetyltransferase
J5252_02735	COG0281	malic enzyme
J5252_02755	COG0114	fumarate hydratase activity
J5252_02765	COG0148	phosphopyruvate hydratase activity
J5252_02770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J5252_02795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J5252_02800	COG0154	amidase activity
J5252_02810	COG2963	transposase activity
J5252_02820	COG2801	Transposase and inactivated derivatives
J5252_02825	COG2801	Transposase and inactivated derivatives
J5252_02845	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J5252_02855	COG0575	Belongs to the CDS family
J5252_02860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J5252_02870	COG0233	cytoplasmic translational termination
J5252_02875	COG0528	UMP kinase activity
J5252_02880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J5252_02885	COG0052	Belongs to the universal ribosomal protein uS2 family
J5252_02895	COG1862	Preprotein translocase
J5252_02935	COG2226	methyltransferase
J5252_02940	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J5252_02945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J5252_02970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J5252_02985	COG2814	Major facilitator Superfamily
J5252_03020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J5252_03025	COG2239	Acts as a magnesium transporter
J5252_03035	COG2801	Transposase and inactivated derivatives
J5252_03040	COG2801	Transposase and inactivated derivatives
J5252_03060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J5252_03080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5252_03090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J5252_03095	COG1074	ATP-dependent DNA helicase activity
J5252_03105	COG2003	Belongs to the UPF0758 family
J5252_03110	COG1714	RDD family
J5252_03120	COG0305	Participates in initiation and elongation during chromosome replication
J5252_03130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5252_03140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J5252_03150	COG0358	DNA primase activity
J5252_03165	COG2801	Transposase and inactivated derivatives
J5252_03170	COG2801	Transposase and inactivated derivatives
J5252_03200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J5252_03215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J5252_03235	COG0424	maF-like protein
J5252_03250	COG1115	amino acid carrier protein
J5252_03305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J5252_03310	COG1530	ribonuclease E activity
J5252_03315	COG0443	Heat shock 70 kDa protein
J5252_03325	COG0626	cystathionine gamma-synthase activity
J5252_03365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J5252_03395	COG1185	polyribonucleotide nucleotidyltransferase activity
J5252_03405	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J5252_03445	COG1840	ABC-type Fe3 transport system, periplasmic component
J5252_03455	COG0681	Belongs to the peptidase S26 family
J5252_03460	COG0443	Heat shock 70 kDa protein
J5252_03465	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
J5252_03470	COG0316	Belongs to the HesB IscA family
J5252_03475	COG0822	iron-sulfur transferase activity
J5252_03480	COG0552	protein localization to endoplasmic reticulum
J5252_03485	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
J5252_03500	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J5252_03500	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J5252_03510	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
J5252_03555	COG2801	Transposase and inactivated derivatives
J5252_03845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J5252_03850	COG3621	Patatin-like phospholipase
J5252_03860	COG1396	sequence-specific DNA binding
J5252_03870	COG2003	Belongs to the UPF0758 family
J5252_03875	COG1396	sequence-specific DNA binding
J5252_03915	COG2984	ABC transporter substrate binding protein
J5252_03920	COG4120	Belongs to the binding-protein-dependent transport system permease family
J5252_04040	COG0666	response to abiotic stimulus
J5252_04165	COG3621	Patatin-like phospholipase
J5252_04185	COG2003	Belongs to the UPF0758 family
J5252_04220	COG2801	Transposase and inactivated derivatives
J5252_04230	COG2963	transposase activity
J5252_04235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5252_04260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J5252_04265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J5252_04270	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J5252_04275	COG0792	nuclease activity
J5252_04285	COG0202	RNA polymerase activity
J5252_04290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J5252_04295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J5252_04305	COG0201	protein transport
J5252_04315	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J5252_04325	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J5252_04335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J5252_04370	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J5252_04385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J5252_04400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J5252_04410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J5252_04425	COG0505	Belongs to the CarA family
J5252_04440	COG1494	fructose-1,6-bisphosphatase
J5252_04450	COG0574	Belongs to the PEP-utilizing enzyme family
J5252_04450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5252_04465	COG3344	reverse transcriptase
J5252_04475	COG1178	ABC-type Fe3 transport system permease component
J5252_04480	COG1054	Belongs to the UPF0176 family
J5252_04485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J5252_04500	COG1090	epimerase
J5252_04525	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5252_04535	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5252_04545	COG0084	hydrolase, TatD family'
J5252_04590	COG0632	four-way junction helicase activity
J5252_04595	COG2255	four-way junction helicase activity
J5252_04630	COG2094	Belongs to the DNA glycosylase MPG family
J5252_04635	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
J5252_04640	COG0772	Belongs to the SEDS family
J5252_04645	COG0651	ATP synthesis coupled electron transport
J5252_04665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J5252_04670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J5252_04675	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
J5252_04685	COG1160	GTP binding
J5252_04710	COG1686	Belongs to the peptidase S11 family
J5252_04715	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J5252_04730	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J5252_04735	COG0758	DNA mediated transformation
J5252_04740	COG0149	triose-phosphate isomerase activity
J5252_04750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J5252_04775	COG2801	Transposase and inactivated derivatives
J5252_04780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J5252_04785	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J5252_04810	COG2801	Transposase and inactivated derivatives
J5252_04815	COG2801	Transposase and inactivated derivatives
J5252_04850	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
J5252_04855	COG3827	peptidoglycan binding
J5252_04880	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J5252_04895	COG2801	Transposase and inactivated derivatives
J5252_04900	COG2801	Transposase and inactivated derivatives
J5252_04910	COG0495	leucyl-tRNA aminoacylation
J5252_04925	COG0776	regulation of translation
J5252_04935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J5252_05000	COG0823	Involved in the tonB-independent uptake of proteins
J5252_05005	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J5252_05010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J5252_05030	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J5252_05040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J5252_05045	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J5252_05045	COG0085	RNA polymerase activity
J5252_05050	COG0222	ribosome binding
J5252_05055	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J5252_05060	COG0081	regulation of translation
J5252_05065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J5252_05070	COG0250	Participates in transcription elongation, termination and antitermination
J5252_05085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J5252_05100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J5252_05110	COG2890	protein-(glutamine-N5) methyltransferase activity
J5252_05120	COG3505	Type IV secretory pathway VirD4
J5252_05125	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
J5252_05140	COG3736	Type IV secretory pathway, component VirB8
J5252_05160	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J5252_05165	COG0174	glutamine synthetase
J5252_05175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J5252_05185	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J5252_05190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J5252_05195	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J5252_05200	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
J5252_05230	COG0567	Dehydrogenase, E1 component
J5252_05240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J5252_05265	COG2111	Na H antiporter
J5252_05265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J5252_05275	COG1006	Multisubunit Na H antiporter MnhC subunit
J5252_05280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J5252_05300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J5252_05310	COG1028	Short-chain dehydrogenase reductase Sdr
J5252_05315	COG1295	ribonuclease BN
J5252_05335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J5252_05340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J5252_05345	COG2205	protein histidine kinase activity
J5252_05345	COG2202	Pas domain
J5252_05350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J5252_05360	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J5252_05370	COG0156	8-amino-7-oxononanoate synthase activity
J5252_05380	COG0326	Molecular chaperone. Has ATPase activity
J5252_05390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J5252_05405	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
J5252_05420	COG0493	'glutamate synthase
J5252_05420	COG0543	2 iron, 2 sulfur cluster binding
J5252_05425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J5252_05435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J5252_05445	COG0482	sulfurtransferase activity
J5252_05460	COG2885	chlorophyll binding
J5252_05465	COG0037	tRNA processing
J5252_05470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J5252_05480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J5252_05525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J5252_05545	COG0167	dihydroorotate dehydrogenase activity
J5252_05555	COG1830	Aldolase
J5252_05565	COG0513	Belongs to the DEAD box helicase family
J5252_05570	COG1278	Cold shock
J5252_05575	COG0312	modulator of DNA gyrase
J5252_05580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J5252_05595	COG4591	ABC-type transport system involved in lipoprotein release permease component
J5252_05620	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
J5252_05625	COG2009	succinate dehydrogenase
J5252_05645	COG1475	DNA binding
J5252_05675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J5252_05690	COG0045	succinate-CoA ligase (ADP-forming) activity
J5252_05695	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J5252_05705	COG0778	Nitroreductase
J5252_05710	COG1268	BioY protein
J5252_05745	COG0723	plastoquinol--plastocyanin reductase activity
J5252_05760	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
J5252_05775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J5252_05780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J5252_05785	COG0142	geranyltranstransferase activity
J5252_05795	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
J5252_05815	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J5252_05825	COG0105	UTP biosynthetic process
J5252_05835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J5252_05850	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5252_05870	COG3451	type IV secretory pathway VirB4
J5252_05885	COG2070	2-Nitropropane dioxygenase
J5252_05895	COG0126	phosphoglycerate kinase activity
J5252_05910	COG0564	pseudouridine synthase activity
J5252_05920	COG0658	competence protein
J5252_05920	COG2333	competence protein COMEC
J5252_05930	COG0259	pyridoxamine-phosphate oxidase activity
J5252_05935	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J5252_05950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J5252_05975	COG0372	Belongs to the citrate synthase family
J5252_05980	COG0268	Binds directly to 16S ribosomal RNA
J5252_05990	COG4974	Belongs to the 'phage' integrase family
J5252_06005	COG0628	permease
J5252_06010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J5252_06010	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J5252_06015	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
J5252_06035	COG3344	reverse transcriptase
J5252_06045	COG1104	cysteine desulfurase activity
J5252_06055	COG0312	modulator of DNA gyrase
J5252_06085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J5252_06085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J5252_06090	COG2801	Transposase and inactivated derivatives
J5252_06095	COG2801	Transposase and inactivated derivatives
J5252_06130	COG0445	tRNA wobble uridine modification
J5252_06150	COG4695	Portal protein
J5252_06165	COG0321	lipoyl(octanoyl) transferase activity
J5252_06180	COG0047	phosphoribosylformylglycinamidine synthase activity
J5252_06205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J5252_06210	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J5252_06225	COG1253	flavin adenine dinucleotide binding
J5252_06230	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J5252_06235	COG0436	Aminotransferase
J5252_06265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J5252_06290	COG1230	cation diffusion facilitator family transporter
J5252_06300	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
J5252_06305	COG1115	amino acid carrier protein
J5252_06310	COG1115	amino acid carrier protein
J5252_06315	COG1183	phosphatidylcholine synthase activity
J5252_06325	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J5252_06330	COG0484	heat shock protein binding
J5252_06335	COG0285	dihydrofolate synthase activity
J5252_06350	COG2867	negative regulation of translational initiation
J5252_06385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J5252_06390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J5252_06400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J5252_06415	COG0101	tRNA pseudouridine synthase activity
J5252_06435	COG2857	Cytochrome c1
J5252_06435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J5252_06445	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J5252_06460	COG0484	heat shock protein binding
J5252_06470	COG0124	histidyl-tRNA synthetase
J5252_06480	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J5252_06490	COG0493	'glutamate synthase
J5252_06490	COG0543	2 iron, 2 sulfur cluster binding
J5252_06495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J5252_06510	COG0750	zinc metalloprotease
J5252_06525	COG0776	regulation of translation
J5252_06530	COG0539	negative regulation of cytoplasmic translation
J5252_06535	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J5252_06560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J5252_06575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J5252_06590	COG0187	DNA topoisomerase II activity
J5252_06610	COG2801	Transposase and inactivated derivatives
J5252_06625	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J5252_06630	COG0254	rRNA binding
J5252_06635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J5252_06640	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
J5252_06660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J5252_06680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J5252_06695	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
J5252_06705	COG3451	type IV secretory pathway VirB4
J5252_06710	COG3704	protein secretion by the type IV secretion system
J5252_06715	COG3704	protein secretion by the type IV secretion system
J5252_06720	COG1340	protein secretion by the type IV secretion system
J5252_06720	COG3704	protein secretion by the type IV secretion system
J5252_06735	COG0742	ribosomal rna small subunit methyltransferase
J5252_06750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J5252_06765	COG3088	subunit of a heme lyase
J5252_06765	COG4235	cytochrome complex assembly
J5252_06785	COG0556	nucleotide-excision repair
J5252_06815	COG0330	HflC and HflK could
J5252_06860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J5252_06870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J5252_06880	COG0009	L-threonylcarbamoyladenylate synthase
J5252_06900	COG0651	ATP synthesis coupled electron transport
J5252_06910	COG0736	holo-[acyl-carrier-protein] synthase activity
J5252_06915	COG0442	prolyl-tRNA aminoacylation
J5252_06950	COG3474	cytochrome
J5252_06965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J5252_06970	COG0142	geranyltranstransferase activity
J5252_06995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J5252_07010	COG0473	3-isopropylmalate dehydrogenase activity
J5252_07020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J5252_07025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5252_07040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J5252_07055	COG0359	binds to the 23S rRNA
J5252_07065	COG0360	Binds together with S18 to 16S ribosomal RNA
J5252_07075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J5252_07080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J5252_07085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5252_07090	COG0629	single-stranded DNA binding
J5252_07120	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J5252_07145	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J5252_07155	COG0612	Peptidase, M16
J5252_07160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J5252_07165	COG0196	riboflavin kinase activity
J5252_07180	COG0450	alkyl hydroperoxide reductase
J5252_07195	COG4974	Belongs to the 'phage' integrase family
J5252_07200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5252_07240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J5252_07245	COG1294	oxidase, subunit
J5252_07250	COG1271	oxidase subunit
J5252_07255	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J5252_07260	COG0612	Peptidase, M16
J5252_07270	COG0343	queuine tRNA-ribosyltransferase activity
J5252_07275	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
J5252_07290	COG0745	RESPONSE REGULATOR receiver
J5252_07295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J5252_07300	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
J5252_07315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J5252_07555	COG3621	Patatin-like phospholipase