locus-tag	class	description
E0495_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
E0495_00020	ENOG4107QJN	gtp cyclohydrolase ii
E0495_00025	ENOG4108V42	Type IV secretion system protein VirB8
E0495_00040	ENOG4108EHY	type IV secretion system
E0495_00055	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
E0495_00065	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
E0495_00070	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
E0495_00075	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
E0495_00090	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
E0495_00095	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
E0495_00100	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
E0495_00105	ENOG4108VZM	50s ribosomal protein L10
E0495_00110	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
E0495_00115	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E0495_00130	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
E0495_00160	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
E0495_00230	ENOG4108R6K	riboflavin synthase, subunit alpha
E0495_00245	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
E0495_00260	ENOG4105K46	50S ribosomal protein l27
E0495_00270	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
E0495_00295	ENOG4108I0Z	Aconitate hydratase
E0495_00300	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
E0495_00310	ENOG4107RZZ	dna polymerase iii epsilon subunit
E0495_00350	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
E0495_00355	ENOG4106D71	domain protein
E0495_00360	ENOG4105DJV	ribulose-phosphate 3-epimerase
E0495_00370	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
E0495_00375	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
E0495_00380	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
E0495_00395	ENOG4105DHZ	alpha beta
E0495_00400	ENOG4107QI6	Cysteine desulfurase
E0495_00415	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E0495_00420	ENOG4105EQR	Transposase IS116 IS110 IS902
E0495_00440	ENOG4107QKV	phosphomannomutase
E0495_00450	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
E0495_00460	ENOG4105CBT	Fructose-1,6-bisphosphatase
E0495_00475	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
E0495_00490	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
E0495_00500	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
E0495_00515	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E0495_00520	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
E0495_00525	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
E0495_00530	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
E0495_00535	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
E0495_00545	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
E0495_00550	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
E0495_00555	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
E0495_00560	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E0495_00565	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
E0495_00570	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
E0495_00575	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
E0495_00580	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
E0495_00585	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
E0495_00590	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
E0495_00595	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
E0495_00605	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E0495_00615	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E0495_00620	ENOG4108ZT0	50S ribosomal protein l17
E0495_00625	ENOG41082FP	UPF0102 protein
E0495_00630	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E0495_00640	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
E0495_00645	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
E0495_00690	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
E0495_00700	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
E0495_00710	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
E0495_00720	ENOG4105CDU	Replicative dna helicase
E0495_00730	ENOG4105VQU	rdd domain containing protein
E0495_00740	ENOG4105W5Q	DNA repair protein (RadC
E0495_00750	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
E0495_00765	ENOG4105FAV	ABC, transporter
E0495_00790	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
E0495_00820	ENOG4105BZG	amino acid carrier protein
E0495_00860	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
E0495_00875	ENOG4105CSH	Transporter
E0495_00885	ENOG4108JYK	Dehydrogenase
E0495_00890	ENOG4108YXA	Membrane
E0495_00900	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
E0495_00905	ENOG4105DUX	Transporter
E0495_00910	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
E0495_00920	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
E0495_00935	ENOG41085Y2	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E0495_00960	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
E0495_00970	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
E0495_00990	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
E0495_01005	ENOG4105C3G	gtp-binding protein
E0495_01015	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
E0495_01035	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
E0495_01040	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
E0495_01045	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
E0495_01050	ENOG4105EAB	amino acid AbC transporter
E0495_01055	ENOG4105E5Q	amino acid AbC transporter
E0495_01060	ENOG4105CDA	abc transporter atp-binding protein
E0495_01085	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
E0495_01090	ENOG41060IM	Heme exporter protein
E0495_01130	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
E0495_01140	ENOG4105F0N	pyrophosphate phospho-hydrolase
E0495_01155	ENOG4105D5G	Transposase
E0495_01160	ENOG4108JHT	EamA-like transporter family
E0495_01185	ENOG4105BZ1	(ABC) transporter
E0495_01225	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
E0495_01265	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
E0495_01270	ENOG4105Y2X	UPF0335 protein
E0495_01275	ENOG4108JU6	CBS domain protein
E0495_01280	ENOG4105C8Y	Acetylornithine aminotransferase
E0495_01285	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E0495_01365	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
E0495_01370	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
E0495_01410	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
E0495_01435	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
E0495_01440	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
E0495_01465	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
E0495_01470	ENOG4108Z6B	deaminase
E0495_01480	ENOG4105CSH	Transporter
E0495_01490	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
E0495_01495	ENOG4105CPP	Dehydrogenase, E1 component
E0495_01530	ENOG4105DR5	peptidase
E0495_01540	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0495_01550	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
E0495_01555	ENOG4105C6K	Malic enzyme
E0495_01595	ENOG4105C75	arginyL-tRNA synthetase
E0495_01605	ENOG4105BZ1	(ABC) transporter
E0495_01620	ENOG4105EKQ	RNA-directed DNA polymerase
E0495_01645	ENOG4105KDC	50s ribosomal protein l28
E0495_01655	ENOG4105WVQ	Fe-S assembly protein IscX
E0495_01665	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
E0495_01700	ENOG4105VIE	preprotein translocase, subunit YajC
E0495_01710	ENOG4105CE9	30S ribosomal protein S2
E0495_01720	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
E0495_01725	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
E0495_01735	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
E0495_01740	ENOG4105KNE	Phosphatidate cytidylyltransferase
E0495_01750	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
E0495_01770	ENOG4105D4A	Cell wall formation (By similarity)
E0495_01780	ENOG4105C7S	Dehydrogenase
E0495_01885	ENOG4105EKQ	RNA-directed DNA polymerase
E0495_01905	ENOG4105CEC	DNA methylase N-4 N-6
E0495_01975	ENOG4105EKQ	RNA-directed DNA polymerase
E0495_02250	ENOG4105W5Q	DNA repair protein (RadC
E0495_02300	ENOG4105EKQ	RNA-directed DNA polymerase
E0495_02365	ENOG4105DA4	cytochrome c-type biogenesis protein
E0495_02385	ENOG4105CK2	sodium dicarboxylate symporter
E0495_02390	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
E0495_02395	ENOG4105CI3	gtp-binding protein typa
E0495_02435	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
E0495_02440	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
E0495_02445	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
E0495_02495	ENOG4105ETU	transcriptional activator (TenA
E0495_02515	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
E0495_02520	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
E0495_02555	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
E0495_02560	ENOG4108IJ6	ABC transporter
E0495_02575	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
E0495_02580	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
E0495_02590	ENOG4105D52	delta-aminolevulinic acid dehydratase
E0495_02595	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
E0495_02620	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
E0495_02625	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
E0495_02630	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
E0495_02635	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
E0495_02640	ENOG4105CSH	Transporter
E0495_02660	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
E0495_02680	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
E0495_02725	ENOG4105DQ6	Transposase
E0495_02765	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
E0495_02770	ENOG4106HA5	Protein of unknown function (DUF2497) 
E0495_02795	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
E0495_02810	ENOG4105DQ6	Transposase
E0495_02820	ENOG4105C8T	Leucyl-tRNA synthetase
E0495_02835	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
E0495_02855	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E0495_02900	ENOG4107SVN	transposase
E0495_02905	ENOG4107QN2	dihydrolipoyl dehydrogenase
E0495_02915	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
E0495_02920	ENOG4105D7Z	glutathione synthase
E0495_02925	ENOG41082WC	Transport-associated protein
E0495_02935	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
E0495_02945	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
E0495_02950	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
E0495_02960	ENOG4108KAG	Cytochrome C oxidase, subunit I
E0495_02980	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
E0495_02990	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
E0495_02995	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
E0495_03020	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E0495_03025	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
E0495_03030	ENOG4105BZ9	Cytochrome C oxidase, subunit I
E0495_03055	ENOG4105EKQ	RNA-directed DNA polymerase
E0495_03070	ENOG4105EKQ	RNA-directed DNA polymerase
E0495_03105	ENOG4105C2C	drug resistance transporter, Bcr CflA
E0495_03145	ENOG4105DHP	deoxycytidine triphosphate deaminase
E0495_03180	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
E0495_03200	ENOG4105DQ6	Transposase
E0495_03210	ENOG4105CJW	magnesium transporter
E0495_03340	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
E0495_03345	ENOG4108Z4V	iron-sulfur cluster assembly
E0495_03350	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
E0495_03355	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
E0495_03360	ENOG4105C3F	Signal peptidase i
E0495_03365	ENOG4105CXT	aspartate transcarbamylase
E0495_03370	ENOG4107QKW	extracellular solute-binding protein family 1
E0495_03395	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
E0495_03440	ENOG4105DC7	peptidase M24
E0495_03530	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
E0495_03535	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
E0495_03540	ENOG4105C8U	phosphate abc transporter
E0495_03545	ENOG4105VG0	50S ribosomal protein l34
E0495_03570	ENOG4107UWY	Methyltransferase
E0495_03575	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E0495_03580	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E0495_03585	ENOG4105EE5	Membrane protein terC
E0495_03615	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
E0495_03630	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
E0495_03635	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
E0495_03645	ENOG4105DQ6	Transposase
E0495_03670	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
E0495_03680	ENOG4105DQ6	Transposase
E0495_03695	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
E0495_03700	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
E0495_03710	ENOG4105CP7	Triose-phosphate isomerase
E0495_03715	ENOG4105C79	DNA protecting protein DprA
E0495_03720	ENOG4108Z4U	Ferredoxin
E0495_03735	ENOG4108UFP	Essential cell division protein (By similarity)
E0495_03740	ENOG4105DZ1	carboxypeptidase
E0495_03750	ENOG4105KPY	Small multidrug resistance protein
E0495_03775	ENOG4105CJN	penicillin-binding protein
E0495_03785	ENOG4105C0P	Mg chelatase subunit ChlI
E0495_03810	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
E0495_03815	ENOG4105E33	succinate dehydrogenase
E0495_03830	ENOG4108ZAI	phosphatidylglycerophosphatase a
E0495_03835	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
E0495_03840	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
E0495_03875	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
E0495_03885	ENOG4105C1V	Peptidase, M16
E0495_03895	ENOG4105C4M	(Ubiquinol oxidase) subunit I
E0495_03900	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
E0495_03905	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
E0495_03925	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E0495_03930	ENOG4105C7I	Dehydrogenase
E0495_03940	ENOG4105BZU	Histidine kinase
E0495_03980	ENOG41072GX	Peptidase M22 Glycoprotease
E0495_03990	ENOG4105MP9	class II Aldolase
E0495_04015	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
E0495_04020	ENOG4105C3J	Cysteine desulfurase
E0495_04045	ENOG4105CFH	Aspartokinase
E0495_04060	ENOG4105D5Q	Arginine ornithine antiporter
E0495_04080	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
E0495_04090	ENOG4105DHJ	ABC, transporter
E0495_04095	ENOG4105CY3	ABC transporter, permease
E0495_04100	ENOG4105VGS	50s ribosomal protein l32
E0495_04110	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
E0495_04120	ENOG4105CAY	ferredoxin--nadp reductase
E0495_04135	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E0495_04150	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
E0495_04155	ENOG4107QIZ	NADH dehydrogenase
E0495_04220	ENOG4107QN2	dihydrolipoyl dehydrogenase
E0495_04225	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E0495_04240	ENOG4105D3R	alkyl hydroperoxide reductase
E0495_04260	ENOG4105DTN	riboflavin biosynthesis protein ribF
E0495_04265	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
E0495_04280	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
E0495_04300	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
E0495_04310	ENOG4108JJ6	Type I secretion system ATPase
E0495_04340	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
E0495_04350	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
E0495_04355	ENOG4105C0B	DNA polymerase III (alpha subunit)
E0495_04360	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
E0495_04365	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
E0495_04380	ENOG4105C83	adenylosuccinate lyase
E0495_04400	ENOG4108MDK	Dehydrogenase
E0495_04405	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
E0495_04410	ENOG4105CSM	endonuclease III
E0495_04420	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
E0495_04490	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
E0495_04510	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
E0495_04525	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
E0495_04555	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
E0495_04560	ENOG4105CAS	nag kinase
E0495_04565	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
E0495_04570	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
E0495_04660	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
E0495_04665	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
E0495_04675	ENOG4105C1J	atp-dependent rna helicase
E0495_04685	ENOG4105EIE	fructose-bisphosphate aldolase
E0495_04695	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
E0495_04700	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
E0495_04725	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
E0495_04730	ENOG4105EEI	dihydropteroate synthase
E0495_04740	ENOG4107ZH2	Coenzyme PQQ synthesis protein C
E0495_04750	ENOG4105K63	Thioredoxin
E0495_04790	ENOG4105DQ6	Transposase
E0495_04815	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
E0495_04820	ENOG41082FS	50S ribosomal protein L31
E0495_04825	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
E0495_04830	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E0495_04845	ENOG4105DC1	bifunctional purine biosynthesis protein purh
E0495_04860	ENOG41082BR	50S ribosomal protein L35
E0495_04870	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
E0495_04910	ENOG4106Q4M	protein secretion by the type IV secretion system
E0495_04915	ENOG4106Q4M	protein secretion by the type IV secretion system
E0495_04930	ENOG4106H78	methyltransferase
E0495_04945	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
E0495_04960	ENOG4105KWW	Biogenesis protein
E0495_04990	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
E0495_05005	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E0495_05010	ENOG4108WIW	Aspartyl protease
E0495_05015	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
E0495_05020	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
E0495_05050	ENOG4105FA0	parb-like partition protein
E0495_05055	ENOG4107QJE	Chromosome Partitioning Protein
E0495_05065	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
E0495_05080	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
E0495_05095	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
E0495_05110	ENOG4108RCM	Nitroreductase
E0495_05115	ENOG4107XYW	BioY family
E0495_05130	ENOG4105EKQ	RNA-directed DNA polymerase
E0495_05150	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
E0495_05165	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
E0495_05180	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E0495_05185	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
E0495_05190	ENOG4105CTB	Polyprenyl synthetase
E0495_05200	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
E0495_05205	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
E0495_05230	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
E0495_05240	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
E0495_05290	ENOG4105EA8	2-Nitropropane dioxygenase
E0495_05305	ENOG4105BZA	Phosphoglycerate kinase
E0495_05315	ENOG41080IJ	Diacylglycerol kinase
E0495_05330	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
E0495_05340	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
E0495_05345	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
E0495_05355	ENOG4107QX3	carboxylase
E0495_05375	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
E0495_05405	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
E0495_05430	ENOG4108JPZ	Monovalent cation H antiporter subunit D
E0495_05435	ENOG4105CNI	cell division protein FtsW
E0495_05440	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
E0495_05445	ENOG4108VX5	3-methyladenine DNA glycosylase
E0495_05470	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
E0495_05495	ENOG4105F8V	Hydrolase, tatD family
E0495_05500	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
E0495_05505	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E0495_05510	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E0495_05515	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E0495_05520	ENOG4105K59	histidine triad (HIT) protein
E0495_05580	ENOG4105C72	UPF0176 protein
E0495_05585	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
E0495_05595	ENOG4105EKQ	RNA-directed DNA polymerase
E0495_05610	ENOG4105NWN	ApaG protein
E0495_05615	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
E0495_05625	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
E0495_05630	ENOG4105C02	permease
E0495_05640	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E0495_05655	ENOG4105BZN	citrate synthase
E0495_05695	ENOG4105DQ6	Transposase
E0495_05750	ENOG4108UQY	Iron-storage protein
E0495_05760	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
E0495_05770	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
E0495_05780	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
E0495_05790	ENOG4105KCK	Peptidoglycan-associated lipoprotein
E0495_05870	ENOG4105C2N	RNA methyltransferase TrmH family group 3
E0495_05875	ENOG4105HFZ	Membrane
E0495_05880	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
E0495_05925	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
E0495_05930	ENOG4105FDK	ABC transporter
E0495_05945	ENOG4105W0E	50S ribosomal protein L33
E0495_05950	ENOG4105C03	ribonuclease
E0495_05965	ENOG4105C28	cystathionine
E0495_05970	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
E0495_05985	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
E0495_05995	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
E0495_06060	ENOG4105EPW	hflc protein
E0495_06065	ENOG4107RIZ	hflk protein
E0495_06105	ENOG4105CB5	ATP-dependent DNA helicase recG
E0495_06130	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
E0495_06145	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
E0495_06155	ENOG4107QPR	SAICAR synthetase
E0495_06160	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
E0495_06195	ENOG4105CHM	Aminotransferase
E0495_06220	ENOG4105C57	major facilitator superfamily
E0495_06230	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
E0495_06255	ENOG4105PGM	cation diffusion facilitator family transporter
E0495_06265	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
E0495_06270	ENOG4105BZG	amino acid carrier protein
E0495_06275	ENOG4105BZG	amino acid carrier protein
E0495_06280	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
E0495_06285	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
E0495_06290	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
E0495_06305	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E0495_06315	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
E0495_06320	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
E0495_06325	ENOG4105C8Y	Acetylornithine aminotransferase
E0495_06330	ENOG4105BZU	Histidine kinase
E0495_06335	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E0495_06340	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
E0495_06370	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
E0495_06385	ENOG4105K5M	30s ribosomal protein S16
E0495_06390	ENOG4105EAH	synthase
E0495_06410	ENOG4105G9V	cytochrome C
E0495_06430	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
E0495_06435	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
E0495_06465	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E0495_06560	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
E0495_06620	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E0495_06635	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E0495_06640	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
E0495_06645	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
E0495_06705	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
E0495_06720	ENOG4108Z1B	Cyclase dehydrase
E0495_06725	ENOG4108R9S	DSBA oxidoreductase
E0495_06755	ENOG4107QMP	dna polymerase iii subunits gamma and tau
E0495_06760	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
E0495_06770	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E0495_06780	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
E0495_06785	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
E0495_06805	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
E0495_06810	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
E0495_06815	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E0495_06825	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E0495_06840	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
E0495_06875	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0495_06880	ENOG4105DZP	Membrane-associated zinc metalloprotease
E0495_06895	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
E0495_06900	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
E0495_06905	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
E0495_06915	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E0495_06945	ENOG4107U9T	Pfam:Ribonuclease_BN
E0495_06950	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
E0495_06960	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
E0495_06980	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E0495_06985	ENOG4105MKQ	Monovalent cation H antiporter subunit C
E0495_06995	ENOG4105C8S	subunit m
E0495_07010	ENOG4108DC2	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
E0495_07020	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
E0495_07030	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
E0495_07050	ENOG4107R3N	Filamentation induced by cAMP protein fic
E0495_07055	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
E0495_07065	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
E0495_07070	ENOG41082QS	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
E0495_07075	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
E0495_07085	ENOG4105BZS	acriflavin resistance protein
E0495_07095	ENOG4105CFQ	glutamine synthetase