locus-tag	class	description
FRT63_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FRT63_00025	COG3736	Type IV secretory pathway, component VirB8
FRT63_00040	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
FRT63_00055	COG2890	protein-(glutamine-N5) methyltransferase activity
FRT63_00060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FRT63_00065	COG0049	tRNA binding
FRT63_00070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FRT63_00075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRT63_00090	COG0250	Participates in transcription elongation, termination and antitermination
FRT63_00095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FRT63_00100	COG0081	regulation of translation
FRT63_00105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FRT63_00115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FRT63_00115	COG0085	RNA polymerase activity
FRT63_00120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRT63_00130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FRT63_00160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRT63_00165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRT63_00170	COG0823	Involved in the tonB-independent uptake of proteins
FRT63_00180	COG0484	heat shock protein binding
FRT63_00245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FRT63_00255	COG0776	regulation of translation
FRT63_00270	COG0495	leucyl-tRNA aminoacylation
FRT63_00280	COG2801	Transposase and inactivated derivatives
FRT63_00295	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FRT63_00310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FRT63_00320	COG3827	peptidoglycan binding
FRT63_00325	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FRT63_00365	COG2801	Transposase and inactivated derivatives
FRT63_00390	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FRT63_00395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRT63_00400	COG2801	Transposase and inactivated derivatives
FRT63_00420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FRT63_00430	COG0149	triose-phosphate isomerase activity
FRT63_00435	COG0758	DNA mediated transformation
FRT63_00440	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FRT63_00455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FRT63_00460	COG1686	Belongs to the peptidase S11 family
FRT63_00470	COG2076	Multidrug Resistance protein
FRT63_00485	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FRT63_00490	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FRT63_00500	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FRT63_00515	COG0187	DNA topoisomerase II activity
FRT63_00540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FRT63_00555	COG1674	ftsk spoiiie
FRT63_00610	COG0307	riboflavin synthase, alpha
FRT63_00620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FRT63_00625	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FRT63_00635	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FRT63_00640	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FRT63_00650	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FRT63_00665	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FRT63_00675	COG1845	cytochrome c oxidase, subunit III
FRT63_00680	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FRT63_00685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FRT63_00695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRT63_00710	COG0215	cysteine-tRNA ligase activity
FRT63_00715	COG3932	Exopolysaccharide synthesis, ExoD
FRT63_00725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FRT63_00730	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FRT63_00740	COG0322	excinuclease ABC activity
FRT63_00750	COG0752	glycyl-tRNA synthetase alpha subunit
FRT63_00760	COG0113	porphobilinogen synthase activity
FRT63_00765	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FRT63_00790	COG1573	uracil-dna glycosylase
FRT63_00795	COG0242	peptide deformylase activity
FRT63_00800	COG0849	cell division
FRT63_00805	COG0024	Methionine aminopeptidase
FRT63_00810	COG0477	Major facilitator Superfamily
FRT63_00815	COG0275	rRNA processing
FRT63_00830	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FRT63_00835	COG0193	aminoacyl-tRNA hydrolase activity
FRT63_00850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRT63_00885	COG2801	Transposase and inactivated derivatives
FRT63_00900	COG0237	dephospho-CoA kinase activity
FRT63_00905	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FRT63_00915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FRT63_00930	COG1253	flavin adenine dinucleotide binding
FRT63_00935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FRT63_00935	COG0519	Catalyzes the synthesis of GMP from XMP
FRT63_00940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRT63_00940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FRT63_00970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FRT63_00975	COG0573	inorganic phosphate transmembrane transporter activity
FRT63_00980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FRT63_00985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FRT63_00995	COG2801	Transposase and inactivated derivatives
FRT63_01010	COG0235	Class ii aldolase
FRT63_01050	COG4804	nuclease activity
FRT63_01055	COG1381	Involved in DNA repair and RecF pathway recombination
FRT63_01060	COG0745	RESPONSE REGULATOR receiver
FRT63_01060	COG3706	GGDEF domain
FRT63_01070	COG2902	Dehydrogenase
FRT63_01075	COG0542	response to heat
FRT63_01095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FRT63_01100	COG1823	symporter activity
FRT63_01115	COG1138	Cytochrome C-type biogenesis protein
FRT63_01135	COG3577	Aspartyl protease
FRT63_01145	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FRT63_01170	COG0756	dUTP diphosphatase activity
FRT63_01175	COG0525	valine-tRNA ligase activity
FRT63_01180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FRT63_01185	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FRT63_01190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FRT63_01195	COG2814	Major facilitator Superfamily
FRT63_01220	COG2801	Transposase and inactivated derivatives
FRT63_01225	COG1322	Protein conserved in bacteria
FRT63_01235	COG3328	transposase activity
FRT63_01285	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FRT63_01445	COG2963	transposase activity
FRT63_01455	COG2801	Transposase and inactivated derivatives
FRT63_01460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FRT63_01465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRT63_01470	COG0109	protoheme IX farnesyltransferase activity
FRT63_01475	COG0328	RNA-DNA hybrid ribonuclease activity
FRT63_01485	COG0459	protein refolding
FRT63_01490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FRT63_01495	COG0354	folic acid binding
FRT63_01500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FRT63_01520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRT63_01530	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FRT63_01535	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FRT63_01540	COG0740	serine-type endopeptidase activity
FRT63_01545	COG0544	peptidyl-prolyl cis-trans isomerase activity
FRT63_01565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FRT63_01575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRT63_01615	COG1115	amino acid carrier protein
FRT63_01625	COG0424	maF-like protein
FRT63_01645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FRT63_01660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FRT63_01665	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FRT63_01670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FRT63_01690	COG2801	Transposase and inactivated derivatives
FRT63_01695	COG2801	Transposase and inactivated derivatives
FRT63_01710	COG0358	DNA primase activity
FRT63_01720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FRT63_01730	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRT63_01740	COG0305	Participates in initiation and elongation during chromosome replication
FRT63_01750	COG1714	RDD family
FRT63_01755	COG2003	Belongs to the UPF0758 family
FRT63_01765	COG1074	ATP-dependent DNA helicase activity
FRT63_01770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FRT63_01780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FRT63_01805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FRT63_01825	COG2801	Transposase and inactivated derivatives
FRT63_01835	COG2239	Acts as a magnesium transporter
FRT63_01855	COG0717	Belongs to the dCTP deaminase family
FRT63_01880	COG2814	Major facilitator Superfamily
FRT63_01895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FRT63_01900	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FRT63_01920	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FRT63_01925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRT63_01930	COG2226	methyltransferase
FRT63_01970	COG1132	(ABC) transporter
FRT63_01980	COG0018	arginyl-trna synthetase
FRT63_02005	COG4133	protoheme IX ABC transporter activity
FRT63_02015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FRT63_02020	COG0477	Major facilitator Superfamily
FRT63_02025	COG0564	pseudouridine synthase activity
FRT63_02030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FRT63_02045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRT63_02055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FRT63_02065	COG0072	phenylalanine-tRNA ligase activity
FRT63_02065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRT63_02075	COG0356	it plays a direct role in the translocation of protons across the membrane
FRT63_02080	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRT63_02100	COG1612	heme a metabolic process
FRT63_02105	COG0439	Biotin carboxylase
FRT63_02115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRT63_02125	COG1053	succinate dehydrogenase
FRT63_02135	COG0194	GDP metabolic process
FRT63_02155	COG0012	GTP binding
FRT63_02165	COG0617	tRNA 3'-terminal CCA addition
FRT63_02195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FRT63_02200	COG0805	protein transport
FRT63_02205	COG1438	arginine binding
FRT63_02210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRT63_02215	COG0765	amino acid transport
FRT63_02220	COG1126	abc transporter atp-binding protein
FRT63_02245	COG0284	orotidine-5'-phosphate decarboxylase activity
FRT63_02255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRT63_02260	COG0525	valine-tRNA ligase activity
FRT63_02280	COG0504	CTP synthase activity
FRT63_02285	COG0590	tRNA wobble adenosine to inosine editing
FRT63_02290	COG0477	Major facilitator Superfamily
FRT63_02300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRT63_02305	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRT63_02305	COG0022	dehydrogenase e1 component
FRT63_02315	COG0481	GTPase activity
FRT63_02345	COG0739	heme binding
FRT63_02350	COG0217	transcriptional regulatory protein
FRT63_02355	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRT63_02365	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FRT63_02370	COG0281	malic enzyme
FRT63_02370	COG0280	phosphate acetyltransferase
FRT63_02390	COG0114	fumarate hydratase activity
FRT63_02395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FRT63_02400	COG0148	phosphopyruvate hydratase activity
FRT63_02405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FRT63_02435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRT63_02440	COG0154	amidase activity
FRT63_02460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FRT63_02515	COG2963	transposase activity
FRT63_02525	COG2801	Transposase and inactivated derivatives
FRT63_02545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FRT63_02555	COG0575	Belongs to the CDS family
FRT63_02560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FRT63_02570	COG0233	cytoplasmic translational termination
FRT63_02575	COG0528	UMP kinase activity
FRT63_02580	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FRT63_02585	COG0052	Belongs to the universal ribosomal protein uS2 family
FRT63_02595	COG1862	Preprotein translocase
FRT63_02630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FRT63_02640	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRT63_02665	COG0653	protein targeting
FRT63_02675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FRT63_02700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FRT63_02705	COG0163	prenyltransferase activity
FRT63_02710	COG3750	Belongs to the UPF0335 family
FRT63_02715	COG4536	flavin adenine dinucleotide binding
FRT63_02720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRT63_02725	COG0649	NAD binding
FRT63_02885	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FRT63_02895	COG0666	response to abiotic stimulus
FRT63_02965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRT63_02970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FRT63_02975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRT63_02995	COG1132	(ABC) transporter
FRT63_03020	COG0697	spore germination
FRT63_03040	COG2003	Belongs to the UPF0758 family
FRT63_03045	COG1396	sequence-specific DNA binding
FRT63_03155	COG2963	transposase activity
FRT63_03160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRT63_03185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FRT63_03190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FRT63_03195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRT63_03200	COG0792	nuclease activity
FRT63_03205	COG0203	ribosomal protein L17
FRT63_03210	COG0202	RNA polymerase activity
FRT63_03215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FRT63_03220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FRT63_03225	COG0563	adenylate kinase activity
FRT63_03230	COG0201	protein transport
FRT63_03235	COG0200	Binds to the 23S rRNA
FRT63_03240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FRT63_03245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FRT63_03250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FRT63_03255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FRT63_03260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FRT63_03265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FRT63_03270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FRT63_03275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FRT63_03280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FRT63_03285	COG0255	Belongs to the universal ribosomal protein uL29 family
FRT63_03290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FRT63_03295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FRT63_03300	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FRT63_03305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FRT63_03310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FRT63_03320	COG0088	Forms part of the polypeptide exit tunnel
FRT63_03325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FRT63_03330	COG0051	transcription antitermination factor activity, RNA binding
FRT63_03335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRT63_03350	COG0505	Belongs to the CarA family
FRT63_03365	COG1494	fructose-1,6-bisphosphatase
FRT63_03375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FRT63_03375	COG0574	Belongs to the PEP-utilizing enzyme family
FRT63_03390	COG3344	reverse transcriptase
FRT63_03400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRT63_03415	COG3547	Transposase (IS116 IS110 IS902 family)
FRT63_03420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FRT63_03430	COG1104	cysteine desulfurase activity
FRT63_03435	COG2945	thiolester hydrolase activity
FRT63_03450	COG0316	Belongs to the HesB IscA family
FRT63_03455	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FRT63_03460	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRT63_03460	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRT63_03470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FRT63_03480	COG2171	N-acyltransferase activity
FRT63_03510	COG0768	penicillin binding
FRT63_03520	COG0606	chelatase, subunit chli
FRT63_03545	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FRT63_03550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FRT63_03565	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FRT63_03570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FRT63_03575	COG0745	RESPONSE REGULATOR receiver
FRT63_03590	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FRT63_03595	COG0343	queuine tRNA-ribosyltransferase activity
FRT63_03605	COG0612	Peptidase, M16
FRT63_03610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FRT63_03620	COG1271	oxidase subunit
FRT63_03625	COG1294	oxidase, subunit
FRT63_03630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FRT63_03670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRT63_03675	COG4974	Belongs to the 'phage' integrase family
FRT63_03695	COG0450	alkyl hydroperoxide reductase
FRT63_03710	COG0196	riboflavin kinase activity
FRT63_03715	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FRT63_03720	COG0612	Peptidase, M16
FRT63_03730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FRT63_03750	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FRT63_03755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FRT63_03785	COG0629	single-stranded DNA binding
FRT63_03790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRT63_03795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FRT63_03800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRT63_03805	COG0587	DNA-directed DNA polymerase activity
FRT63_03810	COG0360	Binds together with S18 to 16S ribosomal RNA
FRT63_03815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FRT63_03820	COG0359	binds to the 23S rRNA
FRT63_03835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FRT63_03850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRT63_03855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FRT63_03865	COG0473	3-isopropylmalate dehydrogenase activity
FRT63_03880	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FRT63_03895	COG0228	four-way junction DNA binding
FRT63_03900	COG0142	geranyltranstransferase activity
FRT63_03905	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FRT63_03920	COG3474	cytochrome
FRT63_03940	COG0442	prolyl-tRNA aminoacylation
FRT63_03945	COG0736	holo-[acyl-carrier-protein] synthase activity
FRT63_03975	COG0009	L-threonylcarbamoyladenylate synthase
FRT63_03985	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FRT63_03995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FRT63_04050	COG0330	HflC and HflK could
FRT63_04080	COG0556	nucleotide-excision repair
FRT63_04100	COG3088	subunit of a heme lyase
FRT63_04100	COG4235	cytochrome complex assembly
FRT63_04120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FRT63_04135	COG0742	ribosomal rna small subunit methyltransferase
FRT63_04150	COG3704	protein secretion by the type IV secretion system
FRT63_04150	COG1340	protein secretion by the type IV secretion system
FRT63_04155	COG3704	protein secretion by the type IV secretion system
FRT63_04160	COG3704	protein secretion by the type IV secretion system
FRT63_04165	COG3451	type IV secretory pathway VirB4
FRT63_04175	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FRT63_04190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FRT63_04200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FRT63_04205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FRT63_04210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FRT63_04230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FRT63_04235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FRT63_04240	COG0254	rRNA binding
FRT63_04245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FRT63_04305	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FRT63_04335	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FRT63_04340	COG0552	protein localization to endoplasmic reticulum
FRT63_04345	COG0822	iron-sulfur transferase activity
FRT63_04350	COG0316	Belongs to the HesB IscA family
FRT63_04355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FRT63_04365	COG0681	Belongs to the peptidase S26 family
FRT63_04370	COG0540	Belongs to the ATCase OTCase family
FRT63_04375	COG1840	ABC-type Fe3 transport system, periplasmic component
FRT63_04425	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FRT63_04430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FRT63_04435	COG1185	polyribonucleotide nucleotidyltransferase activity
FRT63_04470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRT63_04515	COG0626	cystathionine gamma-synthase activity
FRT63_04525	COG0443	Heat shock 70 kDa protein
FRT63_04530	COG1530	ribonuclease E activity
FRT63_04535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FRT63_04570	COG1121	(ABC) transporter
FRT63_04575	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRT63_04635	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FRT63_04640	COG0670	Belongs to the BI1 family
FRT63_04645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRT63_04655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FRT63_04675	COG0531	amino acid
FRT63_04690	COG0527	aspartate kinase activity
FRT63_04720	COG0839	Belongs to the complex I subunit 6 family
FRT63_04725	COG0713	ATP synthesis coupled electron transport
FRT63_04730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRT63_04735	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT63_04740	COG1007	ATP synthesis coupled electron transport
FRT63_04745	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FRT63_04745	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FRT63_04745	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FRT63_04745	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FRT63_04750	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FRT63_04780	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FRT63_04785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FRT63_04790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FRT63_04800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT63_04805	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FRT63_04815	COG0492	ferredoxin-NADP+ reductase activity
FRT63_04825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FRT63_04830	COG0416	fatty acid biosynthetic process
FRT63_04835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FRT63_04840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FRT63_04845	COG1127	ABC transporter
FRT63_04855	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FRT63_04870	COG3344	reverse transcriptase
FRT63_04880	COG1104	cysteine desulfurase activity
FRT63_04885	COG0312	modulator of DNA gyrase
FRT63_04915	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRT63_04915	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRT63_04920	COG2801	Transposase and inactivated derivatives
FRT63_04955	COG0445	tRNA wobble uridine modification
FRT63_04975	COG4695	Portal protein
FRT63_04990	COG0321	lipoyl(octanoyl) transferase activity
FRT63_04995	COG1619	proteins homologs of microcin C7 resistance protein MccF
FRT63_05020	COG0047	phosphoribosylformylglycinamidine synthase activity
FRT63_05035	COG0335	large ribosomal subunit rRNA binding
FRT63_05040	COG0336	Belongs to the RNA methyltransferase TrmD family
FRT63_05045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FRT63_05050	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FRT63_05065	COG1253	flavin adenine dinucleotide binding
FRT63_05070	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FRT63_05100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FRT63_05120	COG1230	cation diffusion facilitator family transporter
FRT63_05130	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FRT63_05135	COG1115	amino acid carrier protein
FRT63_05140	COG1115	amino acid carrier protein
FRT63_05145	COG1183	phosphatidylcholine synthase activity
FRT63_05150	COG0688	phosphatidylethanolamine metabolic process
FRT63_05155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FRT63_05160	COG0484	heat shock protein binding
FRT63_05165	COG0285	dihydrofolate synthase activity
FRT63_05180	COG2867	negative regulation of translational initiation
FRT63_05215	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FRT63_05220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FRT63_05230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRT63_05240	COG0592	DNA-directed DNA polymerase activity
FRT63_05245	COG0101	tRNA pseudouridine synthase activity
FRT63_05260	COG2857	Cytochrome c1
FRT63_05260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FRT63_05265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FRT63_05280	COG0484	heat shock protein binding
FRT63_05290	COG0124	histidyl-tRNA synthetase
FRT63_05295	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FRT63_05300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FRT63_05310	COG0493	'glutamate synthase
FRT63_05310	COG0543	2 iron, 2 sulfur cluster binding
FRT63_05315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FRT63_05330	COG0750	zinc metalloprotease
FRT63_05345	COG0776	regulation of translation
FRT63_05350	COG0539	negative regulation of cytoplasmic translation
FRT63_05355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FRT63_05365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FRT63_05380	COG1160	GTP binding
FRT63_05395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRT63_05400	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FRT63_05420	COG0651	ATP synthesis coupled electron transport
FRT63_05425	COG0772	Belongs to the SEDS family
FRT63_05430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FRT63_05435	COG2094	Belongs to the DNA glycosylase MPG family
FRT63_05445	COG2255	four-way junction helicase activity
FRT63_05450	COG0632	four-way junction helicase activity
FRT63_05470	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FRT63_05490	COG0494	nUDIX hydrolase
FRT63_05495	COG0084	hydrolase, TatD family'
FRT63_05500	COG0039	L-malate dehydrogenase activity
FRT63_05505	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT63_05510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT63_05515	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT63_05540	COG1090	epimerase
FRT63_05560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FRT63_05570	COG1178	ABC-type Fe3 transport system permease component
FRT63_05580	COG3344	reverse transcriptase
FRT63_05595	COG2967	ApaG domain
FRT63_05600	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FRT63_05605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FRT63_05605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FRT63_05610	COG0628	permease
FRT63_05620	COG4974	Belongs to the 'phage' integrase family
FRT63_05630	COG0268	Binds directly to 16S ribosomal RNA
FRT63_05635	COG0372	Belongs to the citrate synthase family
FRT63_05650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FRT63_05660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FRT63_05665	COG0259	pyridoxamine-phosphate oxidase activity
FRT63_05675	COG0658	competence protein
FRT63_05675	COG2333	competence protein COMEC
FRT63_05685	COG0564	pseudouridine synthase activity
FRT63_05700	COG0126	phosphoglycerate kinase activity
FRT63_05710	COG2070	2-Nitropropane dioxygenase
FRT63_05725	COG3451	type IV secretory pathway VirB4
FRT63_05745	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRT63_05760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FRT63_05770	COG0105	UTP biosynthetic process
FRT63_05780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FRT63_05795	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FRT63_05800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FRT63_05810	COG0142	geranyltranstransferase activity
FRT63_05815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRT63_05820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FRT63_05830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FRT63_05835	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
FRT63_05850	COG0723	plastoquinol--plastocyanin reductase activity
FRT63_05885	COG1268	BioY protein
FRT63_05890	COG0778	Nitroreductase
FRT63_05900	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FRT63_05905	COG0045	succinate-CoA ligase (ADP-forming) activity
FRT63_05920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRT63_05945	COG1192	Involved in chromosome partitioning
FRT63_05950	COG1475	DNA binding
FRT63_05970	COG2009	succinate dehydrogenase
FRT63_05975	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FRT63_06005	COG4591	ABC-type transport system involved in lipoprotein release permease component
FRT63_06020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FRT63_06025	COG0312	modulator of DNA gyrase
FRT63_06030	COG1278	Cold shock
FRT63_06035	COG0513	Belongs to the DEAD box helicase family
FRT63_06045	COG1830	Aldolase
FRT63_06055	COG0167	dihydroorotate dehydrogenase activity
FRT63_06060	COG0571	ribonuclease III activity
FRT63_06110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FRT63_06120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRT63_06125	COG0037	tRNA processing
FRT63_06130	COG2885	chlorophyll binding
FRT63_06145	COG0482	sulfurtransferase activity
FRT63_06160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FRT63_06170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRT63_06175	COG0543	2 iron, 2 sulfur cluster binding
FRT63_06175	COG0493	'glutamate synthase
FRT63_06190	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FRT63_06205	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FRT63_06225	COG0326	Molecular chaperone. Has ATPase activity
FRT63_06235	COG0156	8-amino-7-oxononanoate synthase activity
FRT63_06245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FRT63_06250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FRT63_06255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRT63_06260	COG2205	protein histidine kinase activity
FRT63_06260	COG2202	Pas domain
FRT63_06265	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FRT63_06270	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FRT63_06295	COG1295	ribonuclease BN
FRT63_06300	COG1028	Short-chain dehydrogenase reductase Sdr
FRT63_06305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FRT63_06325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRT63_06330	COG1006	Multisubunit Na H antiporter MnhC subunit
FRT63_06340	COG2111	Na H antiporter
FRT63_06340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRT63_06355	COG1758	RNA polymerase activity
FRT63_06365	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FRT63_06375	COG0567	Dehydrogenase, E1 component
FRT63_06400	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FRT63_06410	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FRT63_06415	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FRT63_06420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FRT63_06430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRT63_06440	COG0174	glutamine synthetase