locus-tag	class	description
FRT61_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FRT61_00025	COG3736	Type IV secretory pathway, component VirB8
FRT61_00040	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
FRT61_00055	COG2890	protein-(glutamine-N5) methyltransferase activity
FRT61_00060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FRT61_00065	COG0049	tRNA binding
FRT61_00070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FRT61_00075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRT61_00090	COG0250	Participates in transcription elongation, termination and antitermination
FRT61_00095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FRT61_00100	COG0081	regulation of translation
FRT61_00105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FRT61_00115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FRT61_00115	COG0085	RNA polymerase activity
FRT61_00120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRT61_00135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FRT61_00165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRT61_00170	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRT61_00175	COG0823	Involved in the tonB-independent uptake of proteins
FRT61_00185	COG0484	heat shock protein binding
FRT61_00250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FRT61_00260	COG0776	regulation of translation
FRT61_00275	COG0495	leucyl-tRNA aminoacylation
FRT61_00285	COG2801	Transposase and inactivated derivatives
FRT61_00300	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FRT61_00315	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FRT61_00325	COG3827	peptidoglycan binding
FRT61_00330	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FRT61_00370	COG2801	Transposase and inactivated derivatives
FRT61_00395	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FRT61_00400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRT61_00405	COG2801	Transposase and inactivated derivatives
FRT61_00425	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FRT61_00435	COG0149	triose-phosphate isomerase activity
FRT61_00440	COG0758	DNA mediated transformation
FRT61_00445	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FRT61_00460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FRT61_00465	COG1686	Belongs to the peptidase S11 family
FRT61_00475	COG2076	Multidrug Resistance protein
FRT61_00490	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FRT61_00495	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FRT61_00505	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FRT61_00520	COG0187	DNA topoisomerase II activity
FRT61_00545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FRT61_00560	COG1674	ftsk spoiiie
FRT61_00615	COG0307	riboflavin synthase, alpha
FRT61_00625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FRT61_00630	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FRT61_00640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FRT61_00645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FRT61_00655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FRT61_00670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FRT61_00680	COG1845	cytochrome c oxidase, subunit III
FRT61_00685	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FRT61_00690	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FRT61_00700	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRT61_00715	COG0215	cysteine-tRNA ligase activity
FRT61_00720	COG3932	Exopolysaccharide synthesis, ExoD
FRT61_00730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FRT61_00735	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FRT61_00745	COG0322	excinuclease ABC activity
FRT61_00755	COG0752	glycyl-tRNA synthetase alpha subunit
FRT61_00765	COG0113	porphobilinogen synthase activity
FRT61_00770	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FRT61_00795	COG1573	uracil-dna glycosylase
FRT61_00800	COG0242	peptide deformylase activity
FRT61_00805	COG0849	cell division
FRT61_00810	COG0024	Methionine aminopeptidase
FRT61_00815	COG0477	Major facilitator Superfamily
FRT61_00820	COG0275	rRNA processing
FRT61_00835	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FRT61_00840	COG0193	aminoacyl-tRNA hydrolase activity
FRT61_00855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRT61_00890	COG2801	Transposase and inactivated derivatives
FRT61_00905	COG0237	dephospho-CoA kinase activity
FRT61_00910	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FRT61_00920	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FRT61_00935	COG1253	flavin adenine dinucleotide binding
FRT61_00940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FRT61_00940	COG0519	Catalyzes the synthesis of GMP from XMP
FRT61_00945	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FRT61_00945	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRT61_00975	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FRT61_00980	COG0573	inorganic phosphate transmembrane transporter activity
FRT61_00985	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FRT61_00990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FRT61_01000	COG2801	Transposase and inactivated derivatives
FRT61_01015	COG0235	Class ii aldolase
FRT61_01055	COG4804	nuclease activity
FRT61_01060	COG1381	Involved in DNA repair and RecF pathway recombination
FRT61_01065	COG0745	RESPONSE REGULATOR receiver
FRT61_01065	COG3706	GGDEF domain
FRT61_01075	COG2902	Dehydrogenase
FRT61_01080	COG0542	response to heat
FRT61_01100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FRT61_01105	COG1823	symporter activity
FRT61_01120	COG1138	Cytochrome C-type biogenesis protein
FRT61_01140	COG3577	Aspartyl protease
FRT61_01150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FRT61_01175	COG0756	dUTP diphosphatase activity
FRT61_01180	COG0525	valine-tRNA ligase activity
FRT61_01185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FRT61_01190	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FRT61_01195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FRT61_01200	COG2814	Major facilitator Superfamily
FRT61_01225	COG2801	Transposase and inactivated derivatives
FRT61_01230	COG1322	Protein conserved in bacteria
FRT61_01240	COG3328	transposase activity
FRT61_01290	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FRT61_01450	COG2963	transposase activity
FRT61_01460	COG2801	Transposase and inactivated derivatives
FRT61_01465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FRT61_01470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRT61_01475	COG0109	protoheme IX farnesyltransferase activity
FRT61_01480	COG0328	RNA-DNA hybrid ribonuclease activity
FRT61_01490	COG0459	protein refolding
FRT61_01495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FRT61_01500	COG0354	folic acid binding
FRT61_01505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FRT61_01525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRT61_01535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FRT61_01540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FRT61_01545	COG0740	serine-type endopeptidase activity
FRT61_01550	COG0544	peptidyl-prolyl cis-trans isomerase activity
FRT61_01570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FRT61_01580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRT61_01615	COG1115	amino acid carrier protein
FRT61_01625	COG0424	maF-like protein
FRT61_01645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FRT61_01660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FRT61_01665	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FRT61_01670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FRT61_01690	COG2801	Transposase and inactivated derivatives
FRT61_01695	COG2801	Transposase and inactivated derivatives
FRT61_01710	COG0358	DNA primase activity
FRT61_01720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FRT61_01730	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRT61_01740	COG0305	Participates in initiation and elongation during chromosome replication
FRT61_01750	COG1714	RDD family
FRT61_01755	COG2003	Belongs to the UPF0758 family
FRT61_01765	COG1074	ATP-dependent DNA helicase activity
FRT61_01770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FRT61_01780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FRT61_01805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FRT61_01825	COG2801	Transposase and inactivated derivatives
FRT61_01835	COG2239	Acts as a magnesium transporter
FRT61_01855	COG0717	Belongs to the dCTP deaminase family
FRT61_01880	COG2814	Major facilitator Superfamily
FRT61_01895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FRT61_01900	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FRT61_01920	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FRT61_01925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRT61_01930	COG2226	methyltransferase
FRT61_01970	COG1132	(ABC) transporter
FRT61_01980	COG0018	arginyl-trna synthetase
FRT61_02005	COG4133	protoheme IX ABC transporter activity
FRT61_02015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FRT61_02020	COG0477	Major facilitator Superfamily
FRT61_02025	COG0564	pseudouridine synthase activity
FRT61_02030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FRT61_02045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRT61_02055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FRT61_02065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRT61_02065	COG0072	phenylalanine-tRNA ligase activity
FRT61_02075	COG0356	it plays a direct role in the translocation of protons across the membrane
FRT61_02080	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRT61_02100	COG1612	heme a metabolic process
FRT61_02105	COG0439	Biotin carboxylase
FRT61_02115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRT61_02125	COG1053	succinate dehydrogenase
FRT61_02135	COG0194	GDP metabolic process
FRT61_02155	COG0012	GTP binding
FRT61_02165	COG0617	tRNA 3'-terminal CCA addition
FRT61_02195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FRT61_02200	COG0805	protein transport
FRT61_02205	COG1438	arginine binding
FRT61_02210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRT61_02215	COG0765	amino acid transport
FRT61_02220	COG1126	abc transporter atp-binding protein
FRT61_02245	COG0284	orotidine-5'-phosphate decarboxylase activity
FRT61_02260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRT61_02265	COG0525	valine-tRNA ligase activity
FRT61_02285	COG0504	CTP synthase activity
FRT61_02290	COG0590	tRNA wobble adenosine to inosine editing
FRT61_02295	COG0477	Major facilitator Superfamily
FRT61_02305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRT61_02310	COG0022	dehydrogenase e1 component
FRT61_02310	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRT61_02320	COG0481	GTPase activity
FRT61_02350	COG0739	heme binding
FRT61_02355	COG0217	transcriptional regulatory protein
FRT61_02360	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRT61_02370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FRT61_02375	COG0280	phosphate acetyltransferase
FRT61_02375	COG0281	malic enzyme
FRT61_02395	COG0114	fumarate hydratase activity
FRT61_02400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FRT61_02405	COG0148	phosphopyruvate hydratase activity
FRT61_02410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FRT61_02440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRT61_02445	COG0154	amidase activity
FRT61_02465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FRT61_02520	COG2963	transposase activity
FRT61_02530	COG2801	Transposase and inactivated derivatives
FRT61_02550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FRT61_02560	COG0575	Belongs to the CDS family
FRT61_02565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FRT61_02575	COG0233	cytoplasmic translational termination
FRT61_02580	COG0528	UMP kinase activity
FRT61_02585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FRT61_02590	COG0052	Belongs to the universal ribosomal protein uS2 family
FRT61_02600	COG1862	Preprotein translocase
FRT61_02635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FRT61_02645	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRT61_02670	COG0653	protein targeting
FRT61_02680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FRT61_02705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FRT61_02710	COG0163	prenyltransferase activity
FRT61_02715	COG3750	Belongs to the UPF0335 family
FRT61_02720	COG4536	flavin adenine dinucleotide binding
FRT61_02725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRT61_02730	COG0649	NAD binding
FRT61_02890	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FRT61_02900	COG0666	response to abiotic stimulus
FRT61_02970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRT61_02975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FRT61_02980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRT61_03000	COG1132	(ABC) transporter
FRT61_03025	COG0697	spore germination
FRT61_03045	COG2003	Belongs to the UPF0758 family
FRT61_03050	COG1396	sequence-specific DNA binding
FRT61_03160	COG2963	transposase activity
FRT61_03165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRT61_03190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FRT61_03195	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FRT61_03200	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRT61_03205	COG0792	nuclease activity
FRT61_03210	COG0203	ribosomal protein L17
FRT61_03215	COG0202	RNA polymerase activity
FRT61_03220	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FRT61_03225	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FRT61_03230	COG0563	adenylate kinase activity
FRT61_03235	COG0201	protein transport
FRT61_03240	COG0200	Binds to the 23S rRNA
FRT61_03245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FRT61_03250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FRT61_03255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FRT61_03260	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FRT61_03265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FRT61_03270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FRT61_03275	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FRT61_03280	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FRT61_03285	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FRT61_03290	COG0255	Belongs to the universal ribosomal protein uL29 family
FRT61_03295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FRT61_03300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FRT61_03305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FRT61_03310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FRT61_03315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FRT61_03325	COG0088	Forms part of the polypeptide exit tunnel
FRT61_03330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FRT61_03335	COG0051	transcription antitermination factor activity, RNA binding
FRT61_03340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRT61_03355	COG0505	Belongs to the CarA family
FRT61_03370	COG1494	fructose-1,6-bisphosphatase
FRT61_03380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FRT61_03380	COG0574	Belongs to the PEP-utilizing enzyme family
FRT61_03395	COG3344	reverse transcriptase
FRT61_03405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRT61_03420	COG3547	Transposase (IS116 IS110 IS902 family)
FRT61_03425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FRT61_03435	COG1104	cysteine desulfurase activity
FRT61_03440	COG2945	thiolester hydrolase activity
FRT61_03455	COG0316	Belongs to the HesB IscA family
FRT61_03460	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FRT61_03465	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRT61_03465	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRT61_03475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FRT61_03485	COG2171	N-acyltransferase activity
FRT61_03515	COG0768	penicillin binding
FRT61_03525	COG0606	chelatase, subunit chli
FRT61_03550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FRT61_03555	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FRT61_03570	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FRT61_03575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FRT61_03580	COG0745	RESPONSE REGULATOR receiver
FRT61_03595	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FRT61_03600	COG0343	queuine tRNA-ribosyltransferase activity
FRT61_03610	COG0612	Peptidase, M16
FRT61_03615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FRT61_03625	COG1271	oxidase subunit
FRT61_03630	COG1294	oxidase, subunit
FRT61_03635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FRT61_03675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRT61_03680	COG4974	Belongs to the 'phage' integrase family
FRT61_03700	COG0450	alkyl hydroperoxide reductase
FRT61_03715	COG0196	riboflavin kinase activity
FRT61_03720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FRT61_03725	COG0612	Peptidase, M16
FRT61_03735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FRT61_03755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FRT61_03760	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FRT61_03790	COG0629	single-stranded DNA binding
FRT61_03795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRT61_03800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FRT61_03805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRT61_03810	COG0587	DNA-directed DNA polymerase activity
FRT61_03815	COG0360	Binds together with S18 to 16S ribosomal RNA
FRT61_03820	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FRT61_03825	COG0359	binds to the 23S rRNA
FRT61_03840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FRT61_03855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FRT61_03860	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FRT61_03870	COG0473	3-isopropylmalate dehydrogenase activity
FRT61_03885	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FRT61_03900	COG0228	four-way junction DNA binding
FRT61_03905	COG0142	geranyltranstransferase activity
FRT61_03910	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FRT61_03925	COG3474	cytochrome
FRT61_03945	COG0442	prolyl-tRNA aminoacylation
FRT61_03950	COG0736	holo-[acyl-carrier-protein] synthase activity
FRT61_03980	COG0009	L-threonylcarbamoyladenylate synthase
FRT61_03990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FRT61_04000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FRT61_04050	COG0330	HflC and HflK could
FRT61_04080	COG0556	nucleotide-excision repair
FRT61_04100	COG4235	cytochrome complex assembly
FRT61_04100	COG3088	subunit of a heme lyase
FRT61_04120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FRT61_04135	COG0742	ribosomal rna small subunit methyltransferase
FRT61_04150	COG3704	protein secretion by the type IV secretion system
FRT61_04150	COG1340	protein secretion by the type IV secretion system
FRT61_04155	COG3704	protein secretion by the type IV secretion system
FRT61_04160	COG3704	protein secretion by the type IV secretion system
FRT61_04165	COG3451	type IV secretory pathway VirB4
FRT61_04175	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FRT61_04190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FRT61_04200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FRT61_04205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FRT61_04210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FRT61_04230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FRT61_04235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FRT61_04240	COG0254	rRNA binding
FRT61_04245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FRT61_04305	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FRT61_04335	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FRT61_04340	COG0552	protein localization to endoplasmic reticulum
FRT61_04345	COG0822	iron-sulfur transferase activity
FRT61_04350	COG0316	Belongs to the HesB IscA family
FRT61_04355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FRT61_04365	COG0681	Belongs to the peptidase S26 family
FRT61_04370	COG0540	Belongs to the ATCase OTCase family
FRT61_04375	COG1840	ABC-type Fe3 transport system, periplasmic component
FRT61_04420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FRT61_04425	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FRT61_04430	COG1185	polyribonucleotide nucleotidyltransferase activity
FRT61_04465	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRT61_04510	COG0626	cystathionine gamma-synthase activity
FRT61_04520	COG0443	Heat shock 70 kDa protein
FRT61_04525	COG1530	ribonuclease E activity
FRT61_04530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FRT61_04565	COG1121	(ABC) transporter
FRT61_04570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRT61_04625	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FRT61_04630	COG0670	Belongs to the BI1 family
FRT61_04635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRT61_04645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FRT61_04665	COG0531	amino acid
FRT61_04680	COG0527	aspartate kinase activity
FRT61_04710	COG0839	Belongs to the complex I subunit 6 family
FRT61_04715	COG0713	ATP synthesis coupled electron transport
FRT61_04720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRT61_04725	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT61_04730	COG1007	ATP synthesis coupled electron transport
FRT61_04735	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FRT61_04735	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FRT61_04735	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FRT61_04735	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FRT61_04740	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FRT61_04770	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FRT61_04775	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FRT61_04780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FRT61_04790	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT61_04795	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FRT61_04805	COG0492	ferredoxin-NADP+ reductase activity
FRT61_04815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FRT61_04820	COG0416	fatty acid biosynthetic process
FRT61_04825	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FRT61_04830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FRT61_04835	COG1127	ABC transporter
FRT61_04845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FRT61_04860	COG3344	reverse transcriptase
FRT61_04870	COG1104	cysteine desulfurase activity
FRT61_04875	COG0312	modulator of DNA gyrase
FRT61_04905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRT61_04905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRT61_04910	COG2801	Transposase and inactivated derivatives
FRT61_04945	COG0445	tRNA wobble uridine modification
FRT61_04965	COG4695	Portal protein
FRT61_04980	COG0321	lipoyl(octanoyl) transferase activity
FRT61_04985	COG1619	proteins homologs of microcin C7 resistance protein MccF
FRT61_05000	COG0047	phosphoribosylformylglycinamidine synthase activity
FRT61_05015	COG0335	large ribosomal subunit rRNA binding
FRT61_05020	COG0336	Belongs to the RNA methyltransferase TrmD family
FRT61_05025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FRT61_05030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FRT61_05045	COG1253	flavin adenine dinucleotide binding
FRT61_05050	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FRT61_05080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FRT61_05100	COG1230	cation diffusion facilitator family transporter
FRT61_05110	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FRT61_05115	COG1115	amino acid carrier protein
FRT61_05120	COG1115	amino acid carrier protein
FRT61_05125	COG1183	phosphatidylcholine synthase activity
FRT61_05130	COG0688	phosphatidylethanolamine metabolic process
FRT61_05135	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FRT61_05140	COG0484	heat shock protein binding
FRT61_05145	COG0285	dihydrofolate synthase activity
FRT61_05160	COG2867	negative regulation of translational initiation
FRT61_05195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FRT61_05200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FRT61_05210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRT61_05220	COG0592	DNA-directed DNA polymerase activity
FRT61_05225	COG0101	tRNA pseudouridine synthase activity
FRT61_05240	COG2857	Cytochrome c1
FRT61_05240	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FRT61_05245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FRT61_05260	COG0484	heat shock protein binding
FRT61_05270	COG0124	histidyl-tRNA synthetase
FRT61_05275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FRT61_05280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FRT61_05290	COG0543	2 iron, 2 sulfur cluster binding
FRT61_05290	COG0493	'glutamate synthase
FRT61_05295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FRT61_05310	COG0750	zinc metalloprotease
FRT61_05325	COG0776	regulation of translation
FRT61_05330	COG0539	negative regulation of cytoplasmic translation
FRT61_05335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FRT61_05345	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FRT61_05360	COG1160	GTP binding
FRT61_05375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRT61_05380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FRT61_05400	COG0651	ATP synthesis coupled electron transport
FRT61_05405	COG0772	Belongs to the SEDS family
FRT61_05410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FRT61_05415	COG2094	Belongs to the DNA glycosylase MPG family
FRT61_05425	COG2255	four-way junction helicase activity
FRT61_05430	COG0632	four-way junction helicase activity
FRT61_05450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FRT61_05470	COG0494	nUDIX hydrolase
FRT61_05475	COG0084	hydrolase, TatD family'
FRT61_05480	COG0039	L-malate dehydrogenase activity
FRT61_05485	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT61_05490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT61_05495	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRT61_05520	COG1090	epimerase
FRT61_05540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FRT61_05550	COG1178	ABC-type Fe3 transport system permease component
FRT61_05560	COG3344	reverse transcriptase
FRT61_05575	COG2967	ApaG domain
FRT61_05580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FRT61_05585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FRT61_05585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FRT61_05590	COG0628	permease
FRT61_05600	COG4974	Belongs to the 'phage' integrase family
FRT61_05610	COG0268	Binds directly to 16S ribosomal RNA
FRT61_05615	COG0372	Belongs to the citrate synthase family
FRT61_05630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FRT61_05640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FRT61_05645	COG0259	pyridoxamine-phosphate oxidase activity
FRT61_05655	COG0658	competence protein
FRT61_05655	COG2333	competence protein COMEC
FRT61_05665	COG0564	pseudouridine synthase activity
FRT61_05680	COG0126	phosphoglycerate kinase activity
FRT61_05690	COG2070	2-Nitropropane dioxygenase
FRT61_05705	COG3451	type IV secretory pathway VirB4
FRT61_05725	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRT61_05740	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FRT61_05750	COG0105	UTP biosynthetic process
FRT61_05760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FRT61_05775	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FRT61_05780	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FRT61_05790	COG0142	geranyltranstransferase activity
FRT61_05795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRT61_05800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FRT61_05810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FRT61_05815	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
FRT61_05830	COG0723	plastoquinol--plastocyanin reductase activity
FRT61_05865	COG1268	BioY protein
FRT61_05870	COG0778	Nitroreductase
FRT61_05880	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FRT61_05885	COG0045	succinate-CoA ligase (ADP-forming) activity
FRT61_05900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRT61_05925	COG1192	Involved in chromosome partitioning
FRT61_05930	COG1475	DNA binding
FRT61_05950	COG2009	succinate dehydrogenase
FRT61_05955	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FRT61_05985	COG4591	ABC-type transport system involved in lipoprotein release permease component
FRT61_06000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FRT61_06005	COG0312	modulator of DNA gyrase
FRT61_06010	COG1278	Cold shock
FRT61_06015	COG0513	Belongs to the DEAD box helicase family
FRT61_06025	COG1830	Aldolase
FRT61_06035	COG0167	dihydroorotate dehydrogenase activity
FRT61_06040	COG0571	ribonuclease III activity
FRT61_06090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FRT61_06100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRT61_06105	COG0037	tRNA processing
FRT61_06110	COG2885	chlorophyll binding
FRT61_06125	COG0482	sulfurtransferase activity
FRT61_06140	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FRT61_06150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRT61_06155	COG0493	'glutamate synthase
FRT61_06155	COG0543	2 iron, 2 sulfur cluster binding
FRT61_06170	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FRT61_06185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FRT61_06205	COG0326	Molecular chaperone. Has ATPase activity
FRT61_06215	COG0156	8-amino-7-oxononanoate synthase activity
FRT61_06225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FRT61_06230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FRT61_06235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRT61_06240	COG2202	Pas domain
FRT61_06240	COG2205	protein histidine kinase activity
FRT61_06245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FRT61_06250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FRT61_06270	COG1295	ribonuclease BN
FRT61_06275	COG1028	Short-chain dehydrogenase reductase Sdr
FRT61_06280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FRT61_06300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRT61_06305	COG1006	Multisubunit Na H antiporter MnhC subunit
FRT61_06315	COG2111	Na H antiporter
FRT61_06315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRT61_06330	COG1758	RNA polymerase activity
FRT61_06340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FRT61_06350	COG0567	Dehydrogenase, E1 component
FRT61_06375	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FRT61_06385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FRT61_06390	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FRT61_06395	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FRT61_06405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRT61_06415	COG0174	glutamine synthetase