locus-tag	class	description
WRi_000010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WRi_000050	COG3736	Type IV secretory pathway, component VirB8
WRi_000080	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
WRi_000130	COG0049	tRNA binding
WRi_000140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WRi_000150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WRi_000180	COG0250	Participates in transcription elongation, termination and antitermination
WRi_000190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WRi_000200	COG0081	regulation of translation
WRi_000210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WRi_000230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WRi_000230	COG0085	RNA polymerase activity
WRi_000240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WRi_000260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WRi_000300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WRi_000310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WRi_000430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WRi_000600	COG3827	peptidoglycan binding
WRi_000610	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WRi_000650	COG2801	Transposase and inactivated derivatives
WRi_000790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WRi_000820	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WRi_000860	COG0477	Major facilitator Superfamily
WRi_000870	COG0024	Methionine aminopeptidase
WRi_000880	COG0849	cell division
WRi_000900	COG1573	uracil-dna glycosylase
WRi_000920	COG1034	ATP synthesis coupled electron transport
WRi_000930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WRi_000940	COG0113	porphobilinogen synthase activity
WRi_000960	COG0752	glycyl-tRNA synthetase alpha subunit
WRi_001000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WRi_001010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WRi_001030	COG3932	Exopolysaccharide synthesis, ExoD
WRi_001120	COG1845	cytochrome c oxidase, subunit III
WRi_001140	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WRi_001150	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WRi_001170	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WRi_001190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WRi_001220	COG0307	riboflavin synthase, alpha
WRi_001290	COG1674	ftsk spoiiie
WRi_001320	COG3344	reverse transcriptase
WRi_001420	COG0187	DNA topoisomerase II activity
WRi_001440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WRi_001460	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WRi_001470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WRi_001530	COG1686	Belongs to the peptidase S11 family
WRi_001540	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WRi_001570	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WRi_001580	COG0758	DNA mediated transformation
WRi_001590	COG0149	triose-phosphate isomerase activity
WRi_001660	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WRi_001670	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WRi_001750	COG0237	dephospho-CoA kinase activity
WRi_001760	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WRi_001810	COG1253	flavin adenine dinucleotide binding
WRi_001820	COG0519	Catalyzes the synthesis of GMP from XMP
WRi_001820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WRi_001830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WRi_001830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WRi_001900	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WRi_001910	COG0573	inorganic phosphate transmembrane transporter activity
WRi_001930	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WRi_002000	COG0235	Class ii aldolase
WRi_002100	COG0745	RESPONSE REGULATOR receiver
WRi_002100	COG3706	GGDEF domain
WRi_002120	COG2902	Dehydrogenase
WRi_002130	COG0542	response to heat
WRi_002170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WRi_002180	COG1301	dicarboxylic acid transport
WRi_002210	COG1138	Cytochrome C-type biogenesis protein
WRi_002270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WRi_002320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WRi_002340	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WRi_002350	COG2814	Major facilitator Superfamily
WRi_002400	COG1322	Protein conserved in bacteria
WRi_002440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WRi_002570	COG0280	phosphate acetyltransferase
WRi_002570	COG0281	malic enzyme
WRi_002580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WRi_002610	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WRi_002630	COG0739	heme binding
WRi_002700	COG0805	protein transport
WRi_002710	COG1438	arginine binding
WRi_002720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WRi_002730	COG0765	amino acid transport
WRi_002740	COG1126	abc transporter atp-binding protein
WRi_002770	COG0284	orotidine-5'-phosphate decarboxylase activity
WRi_002810	COG0525	valine-tRNA ligase activity
WRi_002850	COG0504	CTP synthase activity
WRi_002860	COG0590	tRNA wobble adenosine to inosine editing
WRi_002890	COG0477	Major facilitator Superfamily
WRi_002910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WRi_002920	COG0508	dehydrogenase complex catalyzes the overall conversion of
WRi_002920	COG0022	dehydrogenase e1 component
WRi_003010	COG0617	tRNA 3'-terminal CCA addition
WRi_003030	COG0012	GTP binding
WRi_003060	COG0194	GDP metabolic process
WRi_003080	COG1053	succinate dehydrogenase
WRi_003090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WRi_003110	COG0439	Biotin carboxylase
WRi_003160	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WRi_003190	COG0072	phenylalanine-tRNA ligase activity
WRi_003190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WRi_003210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WRi_003230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WRi_003250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WRi_003260	COG0564	pseudouridine synthase activity
WRi_003270	COG0477	Major facilitator Superfamily
WRi_003300	COG4133	protoheme IX ABC transporter activity
WRi_003410	COG0575	Belongs to the CDS family
WRi_003420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WRi_003440	COG0528	UMP kinase activity
WRi_003480	COG1862	Preprotein translocase
WRi_003510	COG3344	reverse transcriptase
WRi_003570	COG0508	dehydrogenase complex catalyzes the overall conversion of
WRi_003630	COG0653	protein targeting
WRi_003660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WRi_003670	COG2801	Transposase and inactivated derivatives
WRi_003700	COG3344	reverse transcriptase
WRi_003740	COG2801	Transposase and inactivated derivatives
WRi_003760	COG0163	prenyltransferase activity
WRi_003780	COG4536	flavin adenine dinucleotide binding
WRi_003790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WRi_003800	COG0649	NAD binding
WRi_003840	COG0018	arginyl-trna synthetase
WRi_003890	COG1132	(ABC) transporter
WRi_003980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WRi_004020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WRi_004030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WRi_004080	COG2814	Major facilitator Superfamily
WRi_004100	COG0717	Belongs to the dCTP deaminase family
WRi_004130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WRi_004140	COG2239	Acts as a magnesium transporter
WRi_004150	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WRi_004240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WRi_004270	COG1074	ATP-dependent DNA helicase activity
WRi_004290	COG2003	Belongs to the UPF0758 family
WRi_004310	COG1714	RDD family
WRi_004330	COG0305	Participates in initiation and elongation during chromosome replication
WRi_004350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WRi_004370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WRi_004380	COG0358	DNA primase activity
WRi_004460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WRi_004470	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WRi_004480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WRi_004550	COG1115	amino acid carrier protein
WRi_004610	COG0354	folic acid binding
WRi_004620	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WRi_004640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WRi_004660	COG1132	(ABC) transporter
WRi_004670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WRi_004680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WRi_004700	COG0544	peptidyl-prolyl cis-trans isomerase activity
WRi_004740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WRi_004760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WRi_004820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WRi_004830	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WRi_004860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WRi_004910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WRi_004940	COG0792	nuclease activity
WRi_004950	COG0203	ribosomal protein L17
WRi_004960	COG0202	RNA polymerase activity
WRi_004980	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WRi_005000	COG0201	protein transport
WRi_005010	COG0200	Binds to the 23S rRNA
WRi_005020	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WRi_005030	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WRi_005040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WRi_005050	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WRi_005060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WRi_005070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WRi_005080	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WRi_005090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WRi_005100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WRi_005120	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WRi_005130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WRi_005140	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WRi_005150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WRi_005190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WRi_005210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WRi_005270	COG1494	fructose-1,6-bisphosphatase
WRi_005300	COG0574	Belongs to the PEP-utilizing enzyme family
WRi_005300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WRi_005330	COG3344	reverse transcriptase
WRi_005620	COG0666	response to abiotic stimulus
WRi_005640	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WRi_005720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WRi_005730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WRi_005740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WRi_005780	COG1132	(ABC) transporter
WRi_005830	COG0697	spore germination
WRi_005870	COG2003	Belongs to the UPF0758 family
WRi_005880	COG1396	sequence-specific DNA binding
WRi_005990	COG0450	alkyl hydroperoxide reductase
WRi_006020	COG0196	riboflavin kinase activity
WRi_006030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WRi_006040	COG0612	Peptidase, M16
WRi_006060	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WRi_006100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WRi_006180	COG0629	single-stranded DNA binding
WRi_006190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WRi_006210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WRi_006220	COG0587	DNA-directed DNA polymerase activity
WRi_006230	COG0360	Binds together with S18 to 16S ribosomal RNA
WRi_006240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WRi_006260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WRi_006330	COG0473	3-isopropylmalate dehydrogenase activity
WRi_006360	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WRi_006420	COG2801	Transposase and inactivated derivatives
WRi_006450	COG1104	cysteine desulfurase activity
WRi_006460	COG2945	thiolester hydrolase activity
WRi_006480	COG0316	Belongs to the HesB IscA family
WRi_006490	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WRi_006500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WRi_006500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WRi_006530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WRi_006550	COG2171	N-acyltransferase activity
WRi_006600	COG0768	penicillin binding
WRi_006620	COG2003	Belongs to the UPF0758 family
WRi_006800	COG0071	Belongs to the small heat shock protein (HSP20) family
WRi_007190	COG4804	nuclease activity
WRi_007250	COG4974	Belongs to the 'phage' integrase family
WRi_007330	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WRi_007350	COG1294	oxidase, subunit
WRi_007360	COG1271	oxidase subunit
WRi_007370	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WRi_007380	COG0612	Peptidase, M16
WRi_007400	COG0343	queuine tRNA-ribosyltransferase activity
WRi_007410	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WRi_007440	COG0745	RESPONSE REGULATOR receiver
WRi_007460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WRi_007490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WRi_007500	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WRi_007540	COG0606	chelatase, subunit chli
WRi_007670	COG0228	four-way junction DNA binding
WRi_007680	COG0142	geranyltranstransferase activity
WRi_007720	COG3474	cytochrome
WRi_007860	COG0009	L-threonylcarbamoyladenylate synthase
WRi_007900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WRi_007990	COG0330	HflC and HflK could
WRi_008060	COG0556	nucleotide-excision repair
WRi_008100	COG4235	cytochrome complex assembly
WRi_008100	COG3088	subunit of a heme lyase
WRi_008130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WRi_008170	COG0742	ribosomal rna small subunit methyltransferase
WRi_008200	COG3704	protein secretion by the type IV secretion system
WRi_008210	COG3704	protein secretion by the type IV secretion system
WRi_008220	COG3704	protein secretion by the type IV secretion system
WRi_008230	COG3451	type IV secretory pathway VirB4
WRi_008250	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WRi_008260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WRi_008280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WRi_008310	COG0138	bifunctional purine biosynthesis protein purh
WRi_008330	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WRi_008340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WRi_008350	COG0254	rRNA binding
WRi_008360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WRi_008410	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WRi_008460	COG1840	ABC-type Fe3 transport system, periplasmic component
WRi_008480	COG0540	Belongs to the ATCase OTCase family
WRi_008500	COG0681	Belongs to the peptidase S26 family
WRi_008510	COG0443	Heat shock 70 kDa protein
WRi_008520	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WRi_008530	COG0316	Belongs to the HesB IscA family
WRi_008540	COG0822	iron-sulfur transferase activity
WRi_008550	COG0552	protein localization to endoplasmic reticulum
WRi_008560	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WRi_008610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
WRi_008620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WRi_008620	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WRi_008640	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
WRi_008720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WRi_008780	COG0626	cystathionine gamma-synthase activity
WRi_008810	COG1530	ribonuclease E activity
WRi_008820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WRi_008850	COG1121	(ABC) transporter
WRi_008860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WRi_008870	COG2801	Transposase and inactivated derivatives
WRi_008900	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WRi_008910	COG0670	Belongs to the BI1 family
WRi_008920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WRi_008940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WRi_008970	COG0531	amino acid
WRi_008990	COG0527	aspartate kinase activity
WRi_009110	COG0839	Belongs to the complex I subunit 6 family
WRi_009120	COG0713	ATP synthesis coupled electron transport
WRi_009130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WRi_009140	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WRi_009150	COG1007	ATP synthesis coupled electron transport
WRi_009160	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WRi_009160	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WRi_009240	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WRi_009270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WRi_009290	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WRi_009320	COG0492	ferredoxin-NADP+ reductase activity
WRi_009330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WRi_009350	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WRi_009360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WRi_009370	COG1127	ABC transporter
WRi_009430	COG3344	reverse transcriptase
WRi_009450	COG1104	cysteine desulfurase activity
WRi_009460	COG0312	modulator of DNA gyrase
WRi_009520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WRi_009520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WRi_009590	COG0006	proline dipeptidase activity
WRi_009700	COG4695	Portal protein
WRi_009720	COG0321	lipoyl(octanoyl) transferase activity
WRi_009750	COG0047	phosphoribosylformylglycinamidine synthase activity
WRi_009770	COG0335	large ribosomal subunit rRNA binding
WRi_009800	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WRi_009830	COG1253	flavin adenine dinucleotide binding
WRi_009870	COG0372	Belongs to the citrate synthase family
WRi_009900	COG4974	Belongs to the 'phage' integrase family
WRi_009930	COG0628	permease
WRi_009950	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WRi_009950	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WRi_009960	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WRi_009970	COG2967	ApaG domain
WRi_009990	COG3344	reverse transcriptase
WRi_010280	COG0666	response to abiotic stimulus
WRi_010300	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WRi_010380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WRi_010390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WRi_010400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WRi_010440	COG1132	(ABC) transporter
WRi_010490	COG0697	spore germination
WRi_010530	COG2003	Belongs to the UPF0758 family
WRi_010540	COG1396	sequence-specific DNA binding
WRi_010570	COG3344	reverse transcriptase
WRi_010590	COG1178	ABC-type Fe3 transport system permease component
WRi_010610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WRi_010700	COG0477	Major facilitator Superfamily
WRi_010760	COG1230	cation diffusion facilitator family transporter
WRi_010780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WRi_010790	COG1115	amino acid carrier protein
WRi_010800	COG1115	amino acid carrier protein
WRi_010810	COG1183	phosphatidylcholine synthase activity
WRi_010820	COG0688	phosphatidylethanolamine metabolic process
WRi_010880	COG0484	heat shock protein binding
WRi_010890	COG0285	dihydrofolate synthase activity
WRi_010910	COG2867	negative regulation of translational initiation
WRi_010920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WRi_010970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WRi_010980	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WRi_011000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WRi_011020	COG0592	DNA-directed DNA polymerase activity
WRi_011060	COG2857	Cytochrome c1
WRi_011060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WRi_011070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WRi_011100	COG0484	heat shock protein binding
WRi_011140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WRi_011160	COG0493	'glutamate synthase
WRi_011160	COG0543	2 iron, 2 sulfur cluster binding
WRi_011200	COG0750	zinc metalloprotease
WRi_011230	COG0776	regulation of translation
WRi_011240	COG0539	negative regulation of cytoplasmic translation
WRi_011250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WRi_011300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WRi_011340	COG0259	pyridoxamine-phosphate oxidase activity
WRi_011360	COG2333	competence protein COMEC
WRi_011360	COG0658	competence protein
WRi_011380	COG0564	pseudouridine synthase activity
WRi_011450	COG2070	2-Nitropropane dioxygenase
WRi_011480	COG3451	type IV secretory pathway VirB4
WRi_011520	COG0508	dehydrogenase complex catalyzes the overall conversion of
WRi_011550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WRi_011610	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WRi_011620	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WRi_011650	COG0142	geranyltranstransferase activity
WRi_011660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WRi_011670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WRi_011720	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
WRi_011790	COG0723	plastoquinol--plastocyanin reductase activity
WRi_011840	COG1268	BioY protein
WRi_011850	COG0778	Nitroreductase
WRi_011910	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WRi_011960	COG1192	Involved in chromosome partitioning
WRi_011970	COG1475	DNA binding
WRi_012000	COG2009	succinate dehydrogenase
WRi_012010	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WRi_012040	COG4591	ABC-type transport system involved in lipoprotein release permease component
WRi_012080	COG0312	modulator of DNA gyrase
WRi_012090	COG1278	Cold shock
WRi_012100	COG0513	Belongs to the DEAD box helicase family
WRi_012130	COG1830	Aldolase
WRi_012150	COG0167	dihydroorotate dehydrogenase activity
WRi_012160	COG0571	ribonuclease III activity
WRi_012230	COG3346	SURF1 family
WRi_012260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WRi_012280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WRi_012300	COG2885	chlorophyll binding
WRi_012350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WRi_012370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WRi_012380	COG0543	2 iron, 2 sulfur cluster binding
WRi_012380	COG0493	'glutamate synthase
WRi_012410	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WRi_012700	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WRi_012740	COG1160	GTP binding
WRi_012820	COG0651	ATP synthesis coupled electron transport
WRi_012830	COG0772	Belongs to the SEDS family
WRi_012840	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WRi_012850	COG2094	Belongs to the DNA glycosylase MPG family
WRi_012890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WRi_012930	COG0084	hydrolase, TatD family'
WRi_012940	COG0039	L-malate dehydrogenase activity
WRi_012950	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WRi_012960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WRi_013020	COG1090	epimerase
WRi_013040	COG0326	Molecular chaperone. Has ATPase activity
WRi_013060	COG0156	8-amino-7-oxononanoate synthase activity
WRi_013090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WRi_013100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WRi_013110	COG2205	protein histidine kinase activity
WRi_013110	COG2202	Pas domain
WRi_013120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WRi_013130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WRi_013190	COG1028	Short-chain dehydrogenase reductase Sdr
WRi_013200	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WRi_013260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WRi_013270	COG1006	Multisubunit Na H antiporter MnhC subunit
WRi_013290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WRi_013290	COG2111	Na H antiporter
WRi_013320	COG1758	RNA polymerase activity
WRi_013340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WRi_013360	COG0567	Dehydrogenase, E1 component
WRi_013420	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WRi_013460	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WRi_013470	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WRi_013480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WRi_013500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WRi_013520	COG0174	glutamine synthetase