locus-tag	class	description
WS0000	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WS0001	COG0592	DNA-directed DNA polymerase activity
WS0002	COG0187	DNA topoisomerase II activity
WS0003	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WS0004	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WS0006	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WS0007	COG0589	response to stress
WS0009	COG3258	Cytochrome c
WS0012	COG5002	protein histidine kinase activity
WS0014	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
WS0017	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WS0018	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
WS0021	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WS0022	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WS0023	COG3706	GGDEF domain
WS0023	COG0745	RESPONSE REGULATOR receiver
WS0024	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
WS0026	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WS0028	COG0437	4 iron, 4 sulfur cluster binding
WS0029	COG3383	formate dehydrogenase (NAD+) activity
WS0033	COG0454	-acetyltransferase
WS0036	COG1086	Polysaccharide biosynthesis protein
WS0037	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WS0039	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WS0040	COG0438	transferase activity, transferring glycosyl groups
WS0042	COG0367	asparagine synthase
WS0044	COG0438	transferase activity, transferring glycosyl groups
WS0046	COG0367	asparagine synthase
WS0052	COG1132	(ABC) transporter
WS0054	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WS0057	COG1077	Cell shape determining protein MreB Mrl
WS0058	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WS0060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WS0061	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
WS0062	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WS0064	COG0107	imidazoleglycerol-phosphate synthase activity
WS0065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WS0067	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
WS0067	COG0517	IMP dehydrogenase activity
WS0070	COG0456	acetyltransferase
WS0071	COG1418	mRNA catabolic process
WS0073	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WS0074	COG0552	protein localization to endoplasmic reticulum
WS0075	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WS0077	COG0745	RESPONSE REGULATOR receiver
WS0078	COG2205	protein histidine kinase activity
WS0080	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WS0081	COG1666	GTP binding
WS0084	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WS0085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WS0088	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WS0090	COG0140	phosphoribosyl-ATP diphosphatase activity
WS0090	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WS0093	COG1090	epimerase
WS0094	COG0840	transmembrane signaling receptor activity
WS0095	COG0835	chemotaxis
WS0096	COG1674	ftsk spoiiie
WS0101	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WS0102	COG0440	acetolactate synthase activity
WS0103	COG0028	Belongs to the TPP enzyme family
WS0105	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WS0106	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WS0108	COG4943	cyclic-guanylate-specific phosphodiesterase activity
WS0110	COG1127	ABC transporter
WS0111	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WS0112	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WS0113	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WS0114	COG2207	Transcriptional regulator
WS0116	COG0243	molybdopterin cofactor binding
WS0117	COG0437	4 iron, 4 sulfur cluster binding
WS0118	COG3301	Polysulphide reductase, NrfD
WS0119	COG0745	RESPONSE REGULATOR receiver
WS0120	COG5002	protein histidine kinase activity
WS0121	COG3005	denitrification pathway
WS0124	COG1053	succinate dehydrogenase
WS0125	COG5002	protein histidine kinase activity
WS0125	COG5001	Diguanylate cyclase
WS0126	COG3383	formate dehydrogenase (NAD+) activity
WS0128	COG0840	transmembrane signaling receptor activity
WS0129	COG2056	Na+-H+ antiporter family
WS0130	COG0129	dihydroxy-acid dehydratase activity
WS0131	COG1832	CoA-binding protein
WS0132	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WS0137	COG1691	(AIR) carboxylase
WS0138	COG1606	tRNA processing
WS0139	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
WS0140	COG3875	lactate racemase activity
WS0142	COG0772	Belongs to the SEDS family
WS0143	COG0564	pseudouridine synthase activity
WS0145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WS0146	COG2884	Cell division ATP-binding protein ftsE
WS0150	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
WS0156	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WS0157	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WS0161	COG2171	N-acyltransferase activity
WS0162	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WS0163	COG0426	domain, Protein
WS0164	COG3123	guanosine phosphorylase activity
WS0167	COG1748	Saccharopine dehydrogenase
WS0168	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WS0170	COG0275	rRNA processing
WS0171	COG0281	malic enzyme
WS0171	COG0280	phosphate acetyltransferase
WS0174	COG1546	Belongs to the CinA family
WS0176	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WS0178	COG3278	Belongs to the heme-copper respiratory oxidase family
WS0186	COG0018	arginyl-trna synthetase
WS0187	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WS0188	COG0194	GDP metabolic process
WS0192	COG1136	(ABC) transporter
WS0193	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WS0194	COG0052	Belongs to the universal ribosomal protein uS2 family
WS0196	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WS0198	COG0398	Pfam SNARE associated Golgi protein
WS0200	COG0398	Pfam SNARE associated Golgi protein
WS0203	COG2233	PERMEase
WS0204	COG1663	tetraacyldisaccharide 4'-kinase activity
WS0206	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WS0207	COG3047	cAMP biosynthetic process
WS0207	COG2885	chlorophyll binding
WS0212	COG5002	protein histidine kinase activity
WS0212	COG0784	Response regulator, receiver
WS0212	COG2205	protein histidine kinase activity
WS0214	COG2201	protein-glutamate methylesterase activity
WS0217	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS0217	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS0218	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WS0219	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WS0220	COG0135	phosphoribosylanthranilate isomerase activity
WS0221	COG2176	DNA-directed DNA polymerase activity
WS0222	COG2890	protein-(glutamine-N5) methyltransferase activity
WS0223	COG0501	Belongs to the peptidase M48B family
WS0224	COG0504	CTP synthase activity
WS0225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WS0226	COG0446	pyridine nucleotide-disulphide oxidoreductase
WS0231	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WS0232	COG0849	cell division
WS0233	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WS0234	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WS0237	COG0318	PFAM AMP-dependent synthetase and ligase
WS0238	COG0528	UMP kinase activity
WS0239	COG1758	RNA polymerase activity
WS0240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WS0241	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WS0243	COG0860	N-Acetylmuramoyl-L-alanine amidase
WS0243	COG2247	cell wall binding repeat
WS0245	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
WS0250	COG0438	transferase activity, transferring glycosyl groups
WS0252	COG0438	transferase activity, transferring glycosyl groups
WS0254	COG0859	PFAM glycosyl transferase family 9
WS0255	COG0438	transferase activity, transferring glycosyl groups
WS0256	COG1132	(ABC) transporter
WS0257	COG0835	chemotaxis
WS0257	COG0784	Response regulator, receiver
WS0259	COG1256	bacterial-type flagellum assembly
WS0264	COG0739	heme binding
WS0264	COG1196	nuclear chromosome segregation
WS0264	COG0741	lytic transglycosylase activity
WS0267	COG0277	FAD linked oxidase domain protein
WS0269	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WS0271	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
WS0274	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WS0280	COG0765	amino acid transport
WS0283	COG3290	protein histidine kinase activity
WS0283	COG0840	transmembrane signaling receptor activity
WS0289	COG4774	siderophore transport
WS0291	COG0586	Pfam SNARE associated Golgi protein
WS0292	COG1360	Flagellar Motor Protein
WS0293	COG0288	reversible hydration of carbon dioxide
WS0294	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WS0295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WS0296	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WS0297	COG0284	orotidine-5'-phosphate decarboxylase activity
WS0299	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WS0302	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WS0305	COG5002	protein histidine kinase activity
WS0306	COG0745	RESPONSE REGULATOR receiver
WS0308	COG0459	protein refolding
WS0309	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WS0311	COG0180	Tryptophanyl-tRNA synthetase
WS0312	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WS0312	COG4106	trans-aconitate 2-methyltransferase activity
WS0313	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WS0314	COG0233	cytoplasmic translational termination
WS0315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WS0318	COG0356	it plays a direct role in the translocation of protons across the membrane
WS0323	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WS0324	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WS0325	COG0424	maF-like protein
WS0327	COG0492	ferredoxin-NADP+ reductase activity
WS0328	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WS0330	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
WS0332	COG0077	Prephenate dehydratase
WS0332	COG1605	Chorismate mutase
WS0333	COG0019	diaminopimelate decarboxylase activity
WS0335	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WS0336	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WS0338	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WS0342	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WS0343	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WS0344	COG3706	GGDEF domain
WS0345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WS0346	COG0670	Belongs to the BI1 family
WS0347	COG0352	thiamine-phosphate diphosphorylase activity
WS0348	COG0287	Prephenate dehydrogenase
WS0350	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WS0351	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
WS0352	COG0612	Peptidase, M16
WS0353	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WS0354	COG0305	Participates in initiation and elongation during chromosome replication
WS0361	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
WS0363	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WS0367	COG2204	response regulator
WS0368	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WS0370	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WS0373	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
WS0374	COG0731	radical SAM domain protein
WS0376	COG0745	RESPONSE REGULATOR receiver
WS0378	COG4191	Histidine kinase
WS0379	COG0484	heat shock protein binding
WS0380	COG0545	Peptidyl-prolyl cis-trans isomerase
WS0381	COG0437	4 iron, 4 sulfur cluster binding
WS0382	COG3301	Polysulphide reductase, NrfD
WS0383	COG1333	cytochrome c biogenesis protein
WS0383	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WS0390	COG1136	(ABC) transporter
WS0394	COG2258	MOSC domain
WS0399	COG3787	Belongs to the UPF0306 family
WS0400	COG1301	dicarboxylic acid transport
WS0402	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WS0409	COG0347	Belongs to the P(II) protein family
WS0410	COG0004	ammonium transporteR
WS0414	COG3706	GGDEF domain
WS0414	COG0745	RESPONSE REGULATOR receiver
WS0415	COG0745	RESPONSE REGULATOR receiver
WS0416	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WS0417	COG0564	pseudouridine synthase activity
WS0420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WS0423	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WS0424	COG0149	triose-phosphate isomerase activity
WS0430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WS0430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WS0432	COG3290	protein histidine kinase activity
WS0432	COG0840	transmembrane signaling receptor activity
WS0436	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WS0438	COG1181	Belongs to the D-alanine--D-alanine ligase family
WS0439	COG1944	ATP diphosphatase activity
WS0440	COG0632	four-way junction helicase activity
WS0442	COG0728	peptidoglycan biosynthetic process
WS0443	COG0215	cysteine-tRNA ligase activity
WS0444	COG0254	rRNA binding
WS0445	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WS0446	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WS0449	COG0436	Aminotransferase
WS0450	COG0460	homoserine dehydrogenase
WS0451	COG0792	nuclease activity
WS0452	COG3118	belongs to the thioredoxin family
WS0454	COG0492	ferredoxin-NADP+ reductase activity
WS0455	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WS0456	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WS0457	COG1242	4 iron, 4 sulfur cluster binding
WS0462	COG0250	Participates in transcription elongation, termination and antitermination
WS0463	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WS0464	COG0081	regulation of translation
WS0465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WS0466	COG0222	ribosome binding
WS0467	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WS0467	COG0085	RNA polymerase activity
WS0468	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WS0469	COG0049	tRNA binding
WS0470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WS0471	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WS0472	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WS0473	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WS0474	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WS0475	COG0649	NAD binding
WS0481	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WS0482	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WS0483	COG0839	Belongs to the complex I subunit 6 family
WS0484	COG0713	ATP synthesis coupled electron transport
WS0485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WS0488	COG1007	ATP synthesis coupled electron transport
WS0494	COG0443	Heat shock 70 kDa protein
WS0495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WS0496	COG1420	regulation of RNA biosynthetic process
WS0499	COG0776	regulation of translation
WS0502	COG0251	oxidation-reduction process
WS0503	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WS0504	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WS0505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WS0506	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
WS0507	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WS0508	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WS0508	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WS0509	COG1192	Involved in chromosome partitioning
WS0510	COG1475	DNA binding
WS0512	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WS0513	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WS0514	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WS0515	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WS0516	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WS0517	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WS0518	COG0811	peptide transport
WS0519	COG0848	biopolymer transport protein
WS0521	COG0823	Involved in the tonB-independent uptake of proteins
WS0525	COG1047	Peptidyl-prolyl cis-trans
WS0526	COG2204	response regulator
WS0528	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WS0543	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WS0547	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WS0548	COG0228	four-way junction DNA binding
WS0550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WS0551	COG0336	Belongs to the RNA methyltransferase TrmD family
WS0552	COG0335	large ribosomal subunit rRNA binding
WS0553	COG1045	serine acetyltransferase
WS0554	COG1166	arginine decarboxylase activity
WS0555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WS0557	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WS0558	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WS0559	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WS0560	COG0347	Belongs to the P(II) protein family
WS0565	COG5016	pyruvate
WS0565	COG0511	ligase activity, forming carbon-carbon bonds
WS0566	COG1570	exodeoxyribonuclease VII activity
WS0567	COG4166	transmembrane transport
WS0568	COG4174	ABC transporter (Permease)
WS0569	COG4239	(ABC) transporter, permease
WS0570	COG4172	Belongs to the ABC transporter superfamily
WS0572	COG0412	Dienelactone hydrolase
WS0573	COG0501	Belongs to the peptidase M48B family
WS0574	COG0754	glutathionylspermidine amidase activity
WS0578	COG0437	4 iron, 4 sulfur cluster binding
WS0580	COG0540	Belongs to the ATCase OTCase family
WS0582	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WS0585	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
WS0586	COG0196	riboflavin kinase activity
WS0587	COG4106	trans-aconitate 2-methyltransferase activity
WS0588	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WS0595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WS0596	COG2176	DNA-directed DNA polymerase activity
WS0598	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WS0599	COG3162	membrane
WS0601	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WS0603	COG0204	Acyl-transferase
WS0605	COG0047	phosphoribosylformylglycinamidine synthase activity
WS0606	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WS0607	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WS0608	COG0793	Belongs to the peptidase S41A family
WS0609	COG0542	response to heat
WS0611	COG0163	prenyltransferase activity
WS0612	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WS0613	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WS0614	COG1040	competence protein
WS0617	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WS0618	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WS0620	COG2264	protein methyltransferase activity
WS0621	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WS0622	COG0688	phosphatidylethanolamine metabolic process
WS0623	COG1183	phosphatidylcholine synthase activity
WS0624	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WS0628	COG0825	malonyl-CoA metabolic process
WS0629	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WS0630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WS0632	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WS0634	COG0348	domain, Protein
WS0638	COG1136	(ABC) transporter
WS0640	COG5002	protein histidine kinase activity
WS0642	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WS0643	COG2194	sulfuric ester hydrolase activity
WS0646	COG0310	cobalt ion transport
WS0651	COG0659	secondary active sulfate transmembrane transporter activity
WS0656	COG1611	Belongs to the LOG family
WS0657	COG0745	RESPONSE REGULATOR receiver
WS0658	COG4191	Histidine kinase
WS0660	COG0252	asparaginase activity
WS0661	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WS0662	COG1027	Aspartate ammonia-lyase
WS0668	COG0500	methyltransferase
WS0670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WS0671	COG0864	Transcriptional regulator
WS0673	COG0864	Transcriptional regulator
WS0674	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
WS0676	COG0101	tRNA pseudouridine synthase activity
WS0678	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WS0680	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WS0680	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WS0681	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WS0690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WS0691	COG1959	2 iron, 2 sulfur cluster binding
WS0696	COG3920	Histidine kinase
WS0697	COG0840	transmembrane signaling receptor activity
WS0698	COG0484	heat shock protein binding
WS0700	COG2863	cytochrome
WS0701	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WS0708	COG0437	4 iron, 4 sulfur cluster binding
WS0709	COG0243	molybdopterin cofactor binding
WS0712	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
WS0719	COG0133	tryptophan synthase activity
WS0720	COG0778	Nitroreductase
WS0721	COG1686	Belongs to the peptidase S11 family
WS0722	COG1301	dicarboxylic acid transport
WS0735	COG0437	4 iron, 4 sulfur cluster binding
WS0737	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WS0738	COG1924	4 iron, 4 sulfur cluster binding
WS0739	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
WS0741	COG2801	Transposase and inactivated derivatives
WS0746	COG0733	neurotransmitter:sodium symporter activity
WS0752	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
WS0753	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WS0761	COG0840	transmembrane signaling receptor activity
WS0762	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WS0764	COG0243	molybdopterin cofactor binding
WS0766	COG0640	Transcriptional regulator
WS0767	COG1309	transcriptional regulator
WS0772	COG2200	EAL domain
WS0774	COG1794	racemase activity, acting on amino acids and derivatives
WS0775	COG2200	EAL domain
WS0775	COG3287	FIST C domain
WS0775	COG2199	diguanylate cyclase activity
WS0776	COG0579	oxidoreductase
WS0778	COG0716	FMN binding
WS0781	COG0519	Catalyzes the synthesis of GMP from XMP
WS0784	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WS0786	COG2171	N-acyltransferase activity
WS0787	COG0351	phosphomethylpyrimidine kinase
WS0788	COG0352	thiamine-phosphate diphosphorylase activity
WS0790	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
WS0791	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
WS0792	COG0298	carbon dioxide binding
WS0795	COG0309	Hydrogenase expression formation protein (HypE)
WS0796	COG0375	protein maturation
WS0799	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WS0800	COG0756	dUTP diphosphatase activity
WS0803	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
WS0804	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WS0806	COG5002	protein histidine kinase activity
WS0806	COG5001	Diguanylate cyclase
WS0808	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WS0809	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WS0810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WS0812	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WS0813	COG0575	Belongs to the CDS family
WS0815	COG0445	tRNA wobble uridine modification
WS0816	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WS0817	COG0268	Binds directly to 16S ribosomal RNA
WS0818	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WS0819	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WS0820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WS0821	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WS0822	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WS0823	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WS0826	COG0574	Belongs to the PEP-utilizing enzyme family
WS0826	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WS0827	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WS0830	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WS0831	COG1053	succinate dehydrogenase
WS0834	COG0589	response to stress
WS0835	COG0303	'Molybdopterin
WS0838	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WS0840	COG1921	L-seryl-tRNASec selenium transferase activity
WS0841	COG3706	GGDEF domain
WS0843	COG0840	transmembrane signaling receptor activity
WS0844	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WS0845	COG0330	HflC and HflK could
WS0848	COG3300	MHYT domain
WS0848	COG5001	Diguanylate cyclase
WS0852	COG3437	response regulator, receiver
WS0853	COG2204	response regulator
WS0854	COG0456	acetyltransferase
WS0855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
WS0856	COG1917	Cupin 2, conserved barrel domain protein
WS0859	COG0840	transmembrane signaling receptor activity
WS0861	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WS0864	COG0840	transmembrane signaling receptor activity
WS0867	COG0357	Ribosomal RNA small subunit methyltransferase G
WS0868	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WS0869	COG0805	protein transport
WS0870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WS0872	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WS0876	COG0210	DNA helicase
WS0878	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WS0879	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
WS0881	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WS0883	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WS0885	COG0811	peptide transport
WS0886	COG0848	biopolymer transport protein
WS0894	COG0151	Belongs to the GarS family
WS0897	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WS0899	COG1185	polyribonucleotide nucleotidyltransferase activity
WS0900	COG0745	RESPONSE REGULATOR receiver
WS0901	COG5002	protein histidine kinase activity
WS0902	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WS0903	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WS0907	COG1116	anion transmembrane transporter activity
WS0908	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WS0911	COG4771	TonB-dependent receptor
WS0916	COG4263	nitrous-oxide reductase activity
WS0920	COG0437	4 iron, 4 sulfur cluster binding
WS0923	COG0348	domain, Protein
WS0924	COG1131	(ABC) transporter
WS0929	COG0840	transmembrane signaling receptor activity
WS0929	COG3290	protein histidine kinase activity
WS0930	COG0697	spore germination
WS0931	COG2095	MarC family integral membrane protein
WS0932	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
WS0934	COG0745	RESPONSE REGULATOR receiver
WS0939	COG0840	transmembrane signaling receptor activity
WS0945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WS0946	COG0581	inorganic phosphate transmembrane transporter activity
WS0947	COG0573	inorganic phosphate transmembrane transporter activity
WS0948	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WS0949	COG3290	protein histidine kinase activity
WS0949	COG0840	transmembrane signaling receptor activity
WS0950	COG0745	RESPONSE REGULATOR receiver
WS0953	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WS0953	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WS0954	COG2022	thiamine diphosphate biosynthetic process
WS0956	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WS0960	COG2831	hemolysin activation secretion protein
WS0962	COG0726	polysaccharide deacetylase
WS0963	COG1979	alcohol dehydrogenase
WS0964	COG3706	GGDEF domain
WS0965	COG2200	EAL domain
WS0965	COG2199	diguanylate cyclase activity
WS0965	COG3287	FIST C domain
WS0968	COG1333	cytochrome c biogenesis protein
WS0968	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WS0969	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
WS0970	COG3005	denitrification pathway
WS0971	COG1077	Cell shape determining protein MreB Mrl
WS0973	COG1971	Probably functions as a manganese efflux pump
WS0978	COG0444	Belongs to the ABC transporter superfamily
WS0979	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WS0981	COG0601	transmembrane transport
WS0982	COG0747	negative chemotaxis
WS0984	COG0747	negative chemotaxis
WS0985	COG0601	transmembrane transport
WS0986	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WS0988	COG1124	(ABC) transporter
WS0989	COG0534	Mate efflux family protein
WS0996	COG0668	transmembrane transport
WS0997	COG0709	Synthesizes selenophosphate from selenide and ATP
WS1004	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WS1006	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WS1008	COG2895	sulfate adenylyltransferase (ATP) activity
WS1009	COG0175	sulfate reduction
WS1010	COG0175	sulfate reduction
WS1013	COG0500	methyltransferase
WS1014	COG2814	Major facilitator Superfamily
WS1016	COG0217	transcriptional regulatory protein
WS1019	COG0776	regulation of translation
WS1021	COG0840	transmembrane signaling receptor activity
WS1024	COG2200	EAL domain
WS1027	COG0166	Belongs to the GPI family
WS1028	COG0205	6-phosphofructokinase activity
WS1030	COG0126	phosphoglycerate kinase activity
WS1032	COG0598	Magnesium transport protein CorA
WS1033	COG0745	RESPONSE REGULATOR receiver
WS1034	COG4191	Histidine kinase
WS1044	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WS1046	COG0803	Belongs to the bacterial solute-binding protein 9 family
WS1050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WS1052	COG2404	hydrolase activity, acting on ester bonds
WS1053	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WS1054	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WS1058	COG1776	CheC inhibitor of MCP methylation
WS1058	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WS1061	COG2081	HI0933 family
WS1064	COG0039	L-malate dehydrogenase activity
WS1065	COG0045	succinate-CoA ligase (ADP-forming) activity
WS1068	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WS1068	COG0674	pyruvate-flavodoxin oxidoreductase activity
WS1069	COG1013	pyruvate-flavodoxin oxidoreductase activity
WS1071	COG0717	Belongs to the dCTP deaminase family
WS1072	COG0511	ligase activity, forming carbon-carbon bonds
WS1074	COG0439	Biotin carboxylase
WS1076	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WS1080	COG2198	Histidine kinase
WS1080	COG0643	Histidine kinase
WS1092	COG4962	Type ii secretion system protein e
WS1094	COG2948	multi-organism process
WS1105	COG1192	Involved in chromosome partitioning
WS1112	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WS1112	COG1116	anion transmembrane transporter activity
WS1114	COG3665	Urea carboxylase-associated protein
WS1115	COG0439	Biotin carboxylase
WS1120	COG0640	Transcriptional regulator
WS1121	COG2217	Heavy metal translocating P-type atpase
WS1124	COG1120	ATPase activity
WS1126	COG4772	TonB-dependent receptor
WS1127	COG0500	methyltransferase
WS1129	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WS1138	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WS1146	COG3383	formate dehydrogenase (NAD+) activity
WS1147	COG0437	4 iron, 4 sulfur cluster binding
WS1149	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WS1157	COG4172	Belongs to the ABC transporter superfamily
WS1159	COG0601	transmembrane transport
WS1166	COG2249	NAD(P)H dehydrogenase (quinone) activity
WS1167	COG1733	regulation of RNA biosynthetic process
WS1168	COG1733	regulation of RNA biosynthetic process
WS1172	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WS1172	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
WS1174	COG3043	anaerobic respiration
WS1176	COG0348	domain, Protein
WS1177	COG0437	4 iron, 4 sulfur cluster binding
WS1178	COG0243	molybdopterin cofactor binding
WS1179	COG0730	response to heat
WS1183	COG1151	hydroxylamine reductase activity
WS1187	COG1049	propionate catabolic process, 2-methylcitrate cycle
WS1188	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WS1189	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WS1193	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WS1195	COG0303	'Molybdopterin
WS1197	COG0314	molybdopterin synthase activity
WS1199	COG0521	Mo-molybdopterin cofactor biosynthetic process
WS1200	COG0315	cyclic pyranopterin monophosphate synthase activity
WS1201	COG0493	'glutamate synthase
WS1202	COG0069	glutamate synthase activity
WS1202	COG0067	glutamate synthase
WS1202	COG0070	glutamate synthase
WS1205	COG0840	transmembrane signaling receptor activity
WS1208	COG0745	RESPONSE REGULATOR receiver
WS1210	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WS1213	COG2201	protein-glutamate methylesterase activity
WS1215	COG1739	Uncharacterized protein family UPF0029
WS1217	COG3290	protein histidine kinase activity
WS1217	COG0840	transmembrane signaling receptor activity
WS1218	COG0165	Argininosuccinate lyase
WS1221	COG0582	viral genome integration into host DNA
WS1222	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WS1222	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WS1225	COG0302	gtp cyclohydrolase
WS1227	COG0585	pseudouridine synthase activity
WS1229	COG0840	transmembrane signaling receptor activity
WS1232	COG4771	TonB-dependent receptor
WS1234	COG0646	methionine synthase
WS1234	COG1410	methionine synthase
WS1238	COG1692	metallophosphoesterase
WS1239	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WS1241	COG0739	heme binding
WS1243	COG0745	RESPONSE REGULATOR receiver
WS1243	COG3706	GGDEF domain
WS1245	COG0495	leucyl-tRNA aminoacylation
WS1247	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WS1248	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WS1249	COG1862	Preprotein translocase
WS1251	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WS1252	COG1074	ATP-dependent DNA helicase activity
WS1253	COG0484	heat shock protein binding
WS1254	COG0789	Transcriptional regulator
WS1256	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WS1256	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
WS1257	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WS1258	COG0653	protein targeting
WS1260	COG2921	Belongs to the UPF0250 family
WS1261	COG0824	Thioesterase
WS1265	COG1132	(ABC) transporter
WS1268	COG1971	Probably functions as a manganese efflux pump
WS1272	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WS1273	COG0157	Belongs to the NadC ModD family
WS1274	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WS1276	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WS1279	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WS1280	COG0191	fructose-bisphosphate aldolase activity
WS1281	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WS1284	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WS1286	COG0706	membrane insertase activity
WS1287	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
WS1289	COG0439	Biotin carboxylase
WS1290	COG1968	undecaprenyl-diphosphatase activity
WS1292	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WS1294	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WS1295	COG0359	binds to the 23S rRNA
WS1300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WS1301	COG1115	amino acid carrier protein
WS1302	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WS1306	COG0537	adenosine 5'-monophosphoramidase activity
WS1307	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WS1308	COG0072	phenylalanine-tRNA ligase activity
WS1308	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS1309	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WS1310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WS1311	COG0539	negative regulation of cytoplasmic translation
WS1311	COG1185	polyribonucleotide nucleotidyltransferase activity
WS1313	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WS1315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WS1316	COG1121	(ABC) transporter
WS1320	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
WS1321	COG0471	metal ion transport
WS1322	COG4783	chaperone-mediated protein folding
WS1323	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WS1325	COG1408	metallophosphoesterase
WS1328	COG4191	Histidine kinase
WS1330	COG1280	lysine exporter protein (LysE YggA)
WS1337	COG5278	phosphoserine phosphatase activity
WS1337	COG0840	transmembrane signaling receptor activity
WS1339	COG2207	Transcriptional regulator
WS1339	COG4753	response regulator
WS1340	COG3852	Histidine kinase
WS1342	COG0569	domain protein
WS1342	COG0475	glutathione-regulated potassium exporter activity
WS1345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WS1346	COG0681	Belongs to the peptidase S26 family
WS1347	COG1994	Peptidase M50
WS1348	COG0698	ribose 5-phosphate isomerase
WS1350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WS1351	COG0133	tryptophan synthase activity
WS1352	COG0586	Pfam SNARE associated Golgi protein
WS1353	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WS1354	COG0012	GTP binding
WS1366	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
WS1370	COG2998	abc-type tungstate transport system, permease component
WS1371	COG4662	Binding-protein-dependent transport system inner membrane component
WS1374	COG1592	Rubrerythrin
WS1376	COG0745	RESPONSE REGULATOR receiver
WS1378	COG0569	domain protein
WS1379	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WS1387	COG1433	Dinitrogenase iron-molybdenum cofactor
WS1390	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
WS1391	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
WS1392	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
WS1394	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
WS1396	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WS1399	COG1053	succinate dehydrogenase
WS1403	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WS1406	COG0840	transmembrane signaling receptor activity
WS1412	COG1918	ferrous iron import across plasma membrane
WS1412	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WS1413	COG1918	ferrous iron import across plasma membrane
WS1416	COG1629	transport
WS1417	COG1538	Outer membrane efflux protein
WS1418	COG1136	(ABC) transporter
WS1418	COG0577	efflux transmembrane transporter activity
WS1419	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WS1421	COG4773	Receptor
WS1425	COG4771	TonB-dependent receptor
WS1427	COG0848	biopolymer transport protein
WS1429	COG0811	peptide transport
WS1430	COG0243	molybdopterin cofactor binding
WS1431	COG0437	4 iron, 4 sulfur cluster binding
WS1434	COG2207	Transcriptional regulator
WS1434	COG4753	response regulator
WS1435	COG0747	negative chemotaxis
WS1443	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
WS1449	COG0124	histidyl-tRNA synthetase
WS1450	COG0859	PFAM glycosyl transferase family 9
WS1452	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
WS1453	COG0372	Belongs to the citrate synthase family
WS1454	COG0538	isocitrate dehydrogenase activity
WS1461	COG1942	4-Oxalocrotonate Tautomerase
WS1462	COG3150	esterase
WS1466	COG0410	ABC transporter
WS1475	COG0788	formyltetrahydrofolate deformylase activity
WS1476	COG0616	signal peptide processing
WS1477	COG0402	S-adenosylhomocysteine deaminase activity
WS1478	COG0668	transmembrane transport
WS1481	COG0785	Cytochrome C biogenesis protein
WS1483	COG0436	Aminotransferase
WS1486	COG1193	negative regulation of DNA recombination
WS1488	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WS1489	COG1987	bacterial-type flagellum assembly
WS1492	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
WS1493	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WS1494	COG0148	phosphopyruvate hydratase activity
WS1497	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WS1499	COG1295	ribonuclease BN
WS1500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WS1501	COG0551	DNA topoisomerase type I activity
WS1501	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WS1503	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WS1508	COG0778	Nitroreductase
WS1509	COG2195	Cleaves the N-terminal amino acid of tripeptides
WS1514	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WS1515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WS1517	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WS1519	COG0343	queuine tRNA-ribosyltransferase activity
WS1527	COG2703	oxygen carrier activity
WS1530	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
WS1533	COG1802	Transcriptional regulator
WS1535	COG2824	Alkylphosphonate utilization operon protein PhnA
WS1536	COG0501	Belongs to the peptidase M48B family
WS1538	COG4269	membrane
WS1540	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WS1541	COG1607	acyl-coa hydrolase
WS1543	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WS1544	COG0415	Belongs to the DNA photolyase family
WS1546	COG0003	Pfam Anion-transporting ATPase
WS1548	COG1966	Carbon starvation protein
WS1550	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
WS1552	COG3639	organic phosphonate transmembrane transporter activity
WS1554	COG0647	UMP catabolic process
WS1555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WS1556	COG3300	MHYT domain
WS1556	COG5001	Diguanylate cyclase
WS1559	COG1136	(ABC) transporter
WS1559	COG0577	efflux transmembrane transporter activity
WS1566	COG0672	)-iron permease
WS1568	COG0745	RESPONSE REGULATOR receiver
WS1568	COG3706	GGDEF domain
WS1577	COG4773	Receptor
WS1578	COG0181	hydroxymethylbilane synthase activity
WS1580	COG0442	prolyl-tRNA aminoacylation
WS1581	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WS1582	COG0142	geranyltranstransferase activity
WS1583	COG5337	Spore coat protein CotH
WS1585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WS1587	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WS1588	COG1253	flavin adenine dinucleotide binding
WS1589	COG0783	Belongs to the Dps family
WS1590	COG3852	Histidine kinase
WS1591	COG3951	Flagellar rod assembly protein muramidase FlgJ
WS1592	COG1706	bacterial-type flagellum-dependent cell motility
WS1597	COG3340	Belongs to the peptidase S51 family
WS1598	COG2957	Belongs to the agmatine deiminase family
WS1600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WS1601	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
WS1603	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WS1603	COG0519	Catalyzes the synthesis of GMP from XMP
WS1604	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WS1607	COG0322	excinuclease ABC activity
WS1610	COG4771	TonB-dependent receptor
WS1616	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
WS1622	COG0497	DNA recombination
WS1623	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WS1628	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WS1630	COG0784	Response regulator, receiver
WS1630	COG3437	response regulator, receiver
WS1635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WS1636	COG0482	sulfurtransferase activity
WS1637	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WS1637	COG1776	CheC inhibitor of MCP methylation
WS1638	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WS1639	COG1191	sigma factor activity
WS1641	COG0455	bacterial-type flagellum organization
WS1642	COG1419	protein localization to endoplasmic reticulum
WS1643	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WS1644	COG0006	proline dipeptidase activity
WS1645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WS1646	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WS1647	COG2081	HI0933 family
WS1648	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WS1651	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
WS1652	COG0525	valine-tRNA ligase activity
WS1653	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WS1655	COG0481	GTPase activity
WS1656	COG0602	queuosine metabolic process
WS1657	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WS1659	COG0720	synthase
WS1660	COG1222	aaa ATPase
WS1669	COG0772	Belongs to the SEDS family
WS1672	COG0840	transmembrane signaling receptor activity
WS1672	COG3290	protein histidine kinase activity
WS1673	COG0840	transmembrane signaling receptor activity
WS1674	COG0534	Mate efflux family protein
WS1677	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WS1678	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WS1681	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WS1682	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
WS1683	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
WS1684	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
WS1685	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
WS1686	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
WS1687	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
WS1688	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WS1691	COG0203	ribosomal protein L17
WS1692	COG0202	RNA polymerase activity
WS1693	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WS1694	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WS1695	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WS1696	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WS1697	COG0024	Methionine aminopeptidase
WS1698	COG0201	protein transport
WS1699	COG0200	Binds to the 23S rRNA
WS1700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WS1701	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WS1702	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WS1703	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WS1704	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WS1705	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WS1706	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WS1707	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WS1709	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WS1710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WS1711	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WS1712	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WS1713	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WS1714	COG0089	rRNA binding
WS1715	COG0088	Forms part of the polypeptide exit tunnel
WS1716	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WS1718	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WS1722	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WS1723	COG0438	transferase activity, transferring glycosyl groups
WS1726	COG3437	response regulator, receiver
WS1727	COG0784	Response regulator, receiver
WS1727	COG5002	protein histidine kinase activity
WS1727	COG2198	Histidine kinase
WS1728	COG0494	nUDIX hydrolase
WS1729	COG0527	aspartate kinase activity
WS1732	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WS1737	COG0326	Molecular chaperone. Has ATPase activity
WS1738	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WS1740	COG0428	transporter
WS1741	COG0390	transport system, permease component
WS1744	COG0450	alkyl hydroperoxide reductase
WS1748	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WS1751	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WS1753	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WS1754	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
WS1758	COG1749	Flagellar hook protein flgE
WS1759	COG1749	Flagellar hook protein flgE
WS1760	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
WS1764	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WS1765	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WS1766	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
WS1768	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WS1769	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WS1770	COG0037	tRNA processing
WS1776	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WS1778	COG0195	Participates in both transcription termination and antitermination
WS1779	COG4773	Receptor
WS1780	COG4773	Receptor
WS1781	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WS1782	COG0563	adenylate kinase activity
WS1784	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WS1785	COG0651	ATP synthesis coupled electron transport
WS1790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WS1792	COG0037	tRNA processing
WS1793	COG2814	Major facilitator Superfamily
WS1795	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WS1798	COG0745	RESPONSE REGULATOR receiver
WS1801	COG4786	Flagellar basal body rod
WS1802	COG4786	Flagellar basal body rod
WS1807	COG0157	Belongs to the NadC ModD family
WS1808	COG4149	molybdate abc transporter
WS1812	COG0066	3-isopropylmalate dehydratase activity
WS1813	COG0473	3-isopropylmalate dehydrogenase activity
WS1817	COG0745	RESPONSE REGULATOR receiver
WS1818	COG0642	Histidine kinase
WS1819	COG0617	tRNA 3'-terminal CCA addition
WS1821	COG0113	porphobilinogen synthase activity
WS1822	COG2823	Periplasmic or secreted lipoprotein
WS1823	COG1280	lysine exporter protein (LysE YggA)
WS1824	COG0628	permease
WS1825	COG2255	four-way junction helicase activity
WS1826	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WS1827	COG0159	tryptophan synthase activity
WS1829	COG1960	acyl-CoA dehydrogenase activity
WS1831	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WS1836	COG3260	NADH ubiquinone oxidoreductase 20
WS1837	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WS1838	COG3261	NADH dehydrogenase
WS1838	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
WS1839	COG0651	ATP synthesis coupled electron transport
WS1840	COG4237	Hydrogenase 4 membrane
WS1841	COG0650	Formate hydrogenlyase subunit 4
WS1842	COG0651	ATP synthesis coupled electron transport
WS1843	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
WS1846	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WS1851	COG2199	diguanylate cyclase activity
WS1851	COG2203	Gaf domain
WS1852	COG1294	oxidase, subunit
WS1853	COG1271	oxidase subunit
WS1857	COG1342	Belongs to the UPF0251 family
WS1860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WS1861	COG3852	Histidine kinase
WS1864	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
WS1868	COG0306	phosphate transporter
WS1869	COG0835	chemotaxis
WS1869	COG0784	Response regulator, receiver
WS1870	COG0157	Belongs to the NadC ModD family
WS1871	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WS1872	COG0629	single-stranded DNA binding
WS1873	COG0360	Binds together with S18 to 16S ribosomal RNA
WS1874	COG1466	dna polymerase III delta subunit
WS1875	COG0557	exoribonuclease II activity
WS1877	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WS1878	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WS1879	COG2894	cell division
WS1880	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
WS1886	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WS1890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WS1893	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WS1895	COG0516	GMP reductase activity
WS1895	COG0517	IMP dehydrogenase activity
WS1896	COG0154	amidase activity
WS1897	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WS1899	COG0571	ribonuclease III activity
WS1900	COG0328	RNA-DNA hybrid ribonuclease activity
WS1902	COG0358	DNA primase activity
WS1903	COG0482	sulfurtransferase activity
WS1905	COG0726	polysaccharide deacetylase
WS1910	COG0248	Ppx GppA phosphatase
WS1911	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WS1912	COG0134	indole-3-glycerol-phosphate synthase activity
WS1914	COG0727	PFAM Uncharacterised protein family (UPF0153)
WS1915	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WS1917	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WS1919	COG0583	DNA-binding transcription factor activity
WS1920	COG1053	succinate dehydrogenase
WS1921	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WS1922	COG2048	Heterodisulfide reductase, subunit B
WS1923	COG0840	transmembrane signaling receptor activity
WS1924	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WS1927	COG5002	protein histidine kinase activity
WS1931	COG2801	Transposase and inactivated derivatives
WS1938	COG2046	Belongs to the sulfate adenylyltransferase family
WS1940	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WS1940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WS1941	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WS1942	COG0489	protein tyrosine kinase activity
WS1943	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WS1944	COG2011	ABC-type metal ion transport system permease component
WS1947	COG2860	membrane
WS1948	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WS1951	COG0840	transmembrane signaling receptor activity
WS1954	COG0745	RESPONSE REGULATOR receiver
WS1956	COG0840	transmembrane signaling receptor activity
WS1958	COG0840	transmembrane signaling receptor activity
WS1960	COG0556	nucleotide-excision repair
WS1964	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WS1966	COG0742	ribosomal rna small subunit methyltransferase
WS1969	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WS1971	COG0736	holo-[acyl-carrier-protein] synthase activity
WS1972	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WS1973	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WS1974	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
WS1975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WS1976	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WS1979	COG1187	pseudouridine synthase activity
WS1980	COG1132	(ABC) transporter
WS1981	COG0784	Response regulator, receiver
WS1981	COG4191	Histidine kinase
WS1983	COG0587	DNA-directed DNA polymerase activity
WS1987	COG0714	Associated with various cellular activities
WS1988	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WS1989	COG0416	fatty acid biosynthetic process
WS1991	COG0105	UTP biosynthetic process
WS1994	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WS1995	COG0450	alkyl hydroperoxide reductase
WS1996	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WS1998	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WS1999	COG1766	The M ring may be actively involved in energy transduction
WS2000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WS2002	COG0418	dihydroorotase activity
WS2003	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
WS2004	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WS2005	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WS2007	COG0746	molybdenum cofactor guanylyltransferase activity
WS2009	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WS2010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WS2013	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WS2015	COG0083	homoserine kinase activity
WS2016	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WS2016	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
WS2017	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WS2018	COG0779	Required for maturation of 30S ribosomal subunits
WS2019	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WS2019	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WS2022	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WS2023	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WS2030	COG0582	viral genome integration into host DNA
WS2037	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WS2038	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WS2039	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WS2040	COG1160	GTP binding
WS2042	COG0697	spore germination
WS2043	COG0735	belongs to the Fur family
WS2046	COG4191	Histidine kinase
WS2047	COG0745	RESPONSE REGULATOR receiver
WS2048	COG0156	8-amino-7-oxononanoate synthase activity
WS2050	COG0505	Belongs to the CarA family
WS2056	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WS2057	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
WS2058	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WS2060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WS2061	COG1086	Polysaccharide biosynthesis protein
WS2062	COG0768	penicillin binding
WS2065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WS2069	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WS2070	COG0131	Imidazoleglycerol-phosphate dehydratase
WS2071	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WS2072	COG1388	LysM domain
WS2072	COG3584	3D domain protein
WS2073	COG0084	hydrolase, TatD family'
WS2076	COG2257	FlhB HrpN YscU SpaS Family
WS2078	COG0193	aminoacyl-tRNA hydrolase activity
WS2079	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WS2080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WS2081	COG0560	Phosphoserine phosphatase
WS2082	COG0835	chemotaxis
WS2083	COG0643	Histidine kinase
WS2083	COG2198	Histidine kinase
WS2084	COG0784	Response regulator, receiver
WS2084	COG0835	chemotaxis
WS2086	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WS2088	COG4753	response regulator
WS2088	COG2207	Transcriptional regulator
WS2089	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WS2092	COG1360	Flagellar Motor Protein
WS2093	COG1338	Plays a role in the flagellum-specific transport system
WS2094	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WS2096	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WS2097	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WS2098	COG0802	atpase or kinase
WS2099	COG1137	ATPase activity
WS2100	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WS2104	COG1610	YqeY-like protein
WS2105	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WS2106	COG1083	cytidylyl-transferase
WS2108	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WS2109	COG2089	acid synthase
WS2110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WS2111	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WS2114	COG0840	transmembrane signaling receptor activity
WS2115	COG0564	pseudouridine synthase activity
WS2116	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WS2116	COG1519	Transferase
WS2117	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WS2118	COG0752	glycyl-tRNA synthetase alpha subunit
WS2121	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WS2124	COG0174	glutamine synthetase
WS2125	COG4221	oxidoreductase activity
WS2126	COG1854	S-ribosylhomocysteine lyase activity
WS2128	COG1013	pyruvate-flavodoxin oxidoreductase activity
WS2130	COG0674	pyruvate-flavodoxin oxidoreductase activity
WS2132	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WS2133	COG0546	phosphoglycolate phosphatase activity
WS2137	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WS2138	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WS2140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WS2143	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WS2147	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WS2148	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
WS2149	COG0237	dephospho-CoA kinase activity
WS2150	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WS2153	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WS2155	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WS2157	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WS2159	COG1333	cytochrome c biogenesis protein
WS2159	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WS2160	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
WS2164	COG0137	argininosuccinate synthase activity
WS2168	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WS2175	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
WS2176	COG2252	PERMEase
WS2177	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
WS2178	COG1213	nucleotidyl transferase
WS2179	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
WS2180	COG3848	Pyruvate phosphate dikinase
WS2180	COG0574	Belongs to the PEP-utilizing enzyme family
WS2182	COG0529	Catalyzes the synthesis of activated sulfate
WS2185	COG0367	asparagine synthase
WS2192	COG0367	asparagine synthase
WS2195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WS2198	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WS2200	COG2205	protein histidine kinase activity
WS2203	COG0583	DNA-binding transcription factor activity
WS2204	COG2855	membrane
WS2207	COG1157	protein secretion by the type III secretion system
WS2209	COG0544	peptidyl-prolyl cis-trans isomerase activity
WS2210	COG0740	serine-type endopeptidase activity
WS2212	COG0242	peptide deformylase activity
WS2213	COG0606	chelatase, subunit chli
WS2214	COG0488	(ABC) transporter
WS2217	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WS2217	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WS2219	COG0167	dihydroorotate dehydrogenase activity
WS2220	COG0612	Peptidase, M16
WS2221	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WS2222	COG1028	Short-chain dehydrogenase reductase Sdr
WS2223	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WS2224	COG0750	zinc metalloprotease
WS2225	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WS2228	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
WS2229	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group