locus-tag	class	description
EZH22_00025	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_00030	COG2814	Major facilitator Superfamily
EZH22_00035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EZH22_00040	COG4569	acetaldehyde dehydrogenase (acetylating) activity
EZH22_00045	COG3971	2-oxopent-4-enoate hydratase activity
EZH22_00055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_00065	COG1355	regulation of microtubule-based process
EZH22_00070	COG1414	Transcriptional regulator
EZH22_00075	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
EZH22_00105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_00120	COG2149	membrane
EZH22_00140	COG0633	Ferredoxin
EZH22_00165	COG1116	anion transmembrane transporter activity
EZH22_00170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_00180	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_00185	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EZH22_00190	COG0004	ammonium transporteR
EZH22_00195	COG3485	protocatechuate 3,4-dioxygenase
EZH22_00200	COG3485	protocatechuate 3,4-dioxygenase
EZH22_00205	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZH22_00225	COG1522	sequence-specific DNA binding
EZH22_00230	COG2814	Major facilitator Superfamily
EZH22_00235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_00240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EZH22_00255	COG0523	cobalamin synthesis protein
EZH22_00265	COG0145	ligase activity
EZH22_00270	COG4647	ligase activity
EZH22_00275	COG0145	ligase activity
EZH22_00305	COG1137	ATPase activity
EZH22_00330	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_00340	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_00405	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EZH22_00415	COG1414	Transcriptional regulator
EZH22_00420	COG0583	DNA-binding transcription factor activity
EZH22_00425	COG0183	Belongs to the thiolase family
EZH22_00430	COG0427	acetyl-CoA hydrolase
EZH22_00435	COG1960	acyl-CoA dehydrogenase activity
EZH22_00440	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
EZH22_00445	COG2301	Belongs to the HpcH HpaI aldolase family
EZH22_00525	COG3258	Cytochrome c
EZH22_00530	COG2010	Cytochrome c
EZH22_00540	COG0785	Cytochrome C biogenesis protein
EZH22_00555	COG2391	methyltransferase activity
EZH22_00595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZH22_00600	COG0444	Belongs to the ABC transporter superfamily
EZH22_00610	COG0625	glutathione transferase activity
EZH22_00620	COG0583	DNA-binding transcription factor activity
EZH22_00625	COG0626	cystathionine gamma-synthase activity
EZH22_00645	COG0745	RESPONSE REGULATOR receiver
EZH22_00650	COG5002	protein histidine kinase activity
EZH22_00695	COG1846	Transcriptional regulator
EZH22_00730	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_00755	COG0583	DNA-binding transcription factor activity
EZH22_00765	COG3971	2-oxopent-4-enoate hydratase activity
EZH22_00795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_00815	COG1802	Transcriptional regulator
EZH22_00830	COG1116	anion transmembrane transporter activity
EZH22_00835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_00850	COG0477	Major facilitator Superfamily
EZH22_00870	COG0477	Major facilitator Superfamily
EZH22_00875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZH22_00895	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_00930	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_00935	COG1126	abc transporter atp-binding protein
EZH22_00970	COG1464	Belongs to the NlpA lipoprotein family
EZH22_00975	COG0784	Response regulator, receiver
EZH22_00975	COG2205	protein histidine kinase activity
EZH22_00975	COG5002	protein histidine kinase activity
EZH22_00980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EZH22_00985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EZH22_00985	COG4651	solute:proton antiporter activity
EZH22_00995	COG1121	(ABC) transporter
EZH22_01000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EZH22_01005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EZH22_01015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EZH22_01025	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EZH22_01035	COG2514	catechol 2,3-dioxygenase activity
EZH22_01050	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZH22_01050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZH22_01060	COG0604	alcohol dehydrogenase
EZH22_01070	COG0154	amidase activity
EZH22_01085	COG4948	Mandelate Racemase Muconate Lactonizing
EZH22_01100	COG1116	anion transmembrane transporter activity
EZH22_01105	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_01140	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_01165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EZH22_01180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EZH22_01185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EZH22_01195	COG1201	RNA secondary structure unwinding
EZH22_01205	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EZH22_01210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EZH22_01230	COG0066	3-isopropylmalate dehydratase activity
EZH22_01235	COG3038	cytochrome b561
EZH22_01245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EZH22_01255	COG1285	pathogenesis
EZH22_01265	COG1609	Transcriptional regulator
EZH22_01270	COG2084	Dehydrogenase
EZH22_01280	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EZH22_01285	COG1194	a g-specific adenine glycosylase
EZH22_01295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EZH22_01305	COG0583	DNA-binding transcription factor activity
EZH22_01315	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EZH22_01330	COG1309	transcriptional regulator
EZH22_01350	COG1309	transcriptional regulator
EZH22_01355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EZH22_01360	COG2011	ABC-type metal ion transport system permease component
EZH22_01365	COG1464	Belongs to the NlpA lipoprotein family
EZH22_01370	COG4106	trans-aconitate 2-methyltransferase activity
EZH22_01375	COG0174	glutamine synthetase
EZH22_01405	COG2827	Endonuclease containing a URI domain
EZH22_01435	COG1475	DNA binding
EZH22_01460	COG5489	Protein of unknown function (DUF736)
EZH22_01490	COG1192	Involved in chromosome partitioning
EZH22_01535	COG0583	DNA-binding transcription factor activity
EZH22_01545	COG0656	L-ascorbic acid biosynthetic process
EZH22_01585	COG3451	type IV secretory pathway VirB4
EZH22_01605	COG3701	Conjugal transfer protein
EZH22_01630	COG0667	Aldo Keto reductase
EZH22_01635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_01645	COG2072	flavoprotein involved in K transport
EZH22_01650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_01655	COG1116	anion transmembrane transporter activity
EZH22_01695	COG1045	serine acetyltransferase
EZH22_01700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZH22_01705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EZH22_01725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZH22_01730	COG0444	Belongs to the ABC transporter superfamily
EZH22_01735	COG4608	Belongs to the ABC transporter superfamily
EZH22_01740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_01750	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_01775	COG1959	2 iron, 2 sulfur cluster binding
EZH22_01790	COG1116	anion transmembrane transporter activity
EZH22_01795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_01800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_01810	COG1053	succinate dehydrogenase
EZH22_01830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_01835	COG1116	anion transmembrane transporter activity
EZH22_01840	COG1858	cytochrome C peroxidase
EZH22_01855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_01860	COG1116	anion transmembrane transporter activity
EZH22_01870	COG4974	Belongs to the 'phage' integrase family
EZH22_01885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_01890	COG0842	Transport permease protein
EZH22_01890	COG1129	ABC transporter
EZH22_01895	COG0842	Transport permease protein
EZH22_01925	COG1309	transcriptional regulator
EZH22_01960	COG1960	acyl-CoA dehydrogenase activity
EZH22_01975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_01980	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_01990	COG0633	Ferredoxin
EZH22_01995	COG1522	sequence-specific DNA binding
EZH22_02005	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZH22_02010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZH22_02060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_02100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EZH22_02105	COG1487	ribonuclease activity
EZH22_02130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EZH22_02165	COG1960	acyl-CoA dehydrogenase activity
EZH22_02170	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_02175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_02180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_02220	COG4372	Transposase
EZH22_02225	COG3436	PFAM IS66 Orf2 family protein
EZH22_02230	COG2963	transposase activity
EZH22_02240	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EZH22_02245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_02255	COG0604	alcohol dehydrogenase
EZH22_02270	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_02295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_02310	COG2814	Major facilitator Superfamily
EZH22_02315	COG1802	Transcriptional regulator
EZH22_02345	COG0583	DNA-binding transcription factor activity
EZH22_02365	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_02370	COG1032	radical SAM domain protein
EZH22_02395	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_02405	COG0583	DNA-binding transcription factor activity
EZH22_02440	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EZH22_02445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_02450	COG1335	isochorismatase
EZH22_02455	COG1414	Transcriptional regulator
EZH22_02465	COG0477	Major facilitator Superfamily
EZH22_02470	COG0028	Belongs to the TPP enzyme family
EZH22_02490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZH22_02495	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EZH22_02500	COG2080	2 iron, 2 sulfur cluster binding
EZH22_02510	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EZH22_02530	COG0583	DNA-binding transcription factor activity
EZH22_02545	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EZH22_02555	COG0583	DNA-binding transcription factor activity
EZH22_02600	COG0183	Belongs to the thiolase family
EZH22_02615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZH22_02620	COG4770	biotin carboxylase activity
EZH22_02635	COG1024	Enoyl-CoA hydratase
EZH22_02640	COG1960	acyl-CoA dehydrogenase activity
EZH22_02665	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_02670	COG1022	Amp-dependent synthetase and ligase
EZH22_02675	COG1137	ATPase activity
EZH22_02695	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_02700	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_02700	COG1024	Enoyl-CoA hydratase
EZH22_02715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_02725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_02725	COG1116	anion transmembrane transporter activity
EZH22_02745	COG0583	DNA-binding transcription factor activity
EZH22_02785	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_02800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_02805	COG0583	DNA-binding transcription factor activity
EZH22_02825	COG2171	N-acyltransferase activity
EZH22_02830	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EZH22_02840	COG2186	Transcriptional regulator
EZH22_02845	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_02870	COG1131	(ABC) transporter
EZH22_02885	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_02890	COG0277	FAD linked oxidase domain protein
EZH22_02910	COG1692	metallophosphoesterase
EZH22_02915	COG0217	transcriptional regulatory protein
EZH22_02920	COG0789	Transcriptional regulator
EZH22_02930	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EZH22_02940	COG0632	four-way junction helicase activity
EZH22_02950	COG2255	four-way junction helicase activity
EZH22_02965	COG0824	Thioesterase
EZH22_02985	COG0823	Involved in the tonB-independent uptake of proteins
EZH22_02990	COG2885	chlorophyll binding
EZH22_03000	COG0037	tRNA processing
EZH22_03005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EZH22_03035	COG3588	fructose-bisphosphate aldolase
EZH22_03040	COG0352	thiamine-phosphate diphosphorylase activity
EZH22_03060	COG0024	Methionine aminopeptidase
EZH22_03065	COG2003	Belongs to the UPF0758 family
EZH22_03080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZH22_03085	COG3842	ATPase activity
EZH22_03100	COG0395	ABC-type sugar transport system, permease component
EZH22_03120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EZH22_03120	COG0574	Belongs to the PEP-utilizing enzyme family
EZH22_03130	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_03135	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EZH22_03140	COG0045	succinate-CoA ligase (ADP-forming) activity
EZH22_03150	COG4191	Histidine kinase
EZH22_03155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_03165	COG1802	Transcriptional regulator
EZH22_03185	COG1414	Transcriptional regulator
EZH22_03190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EZH22_03195	COG1238	metal cluster binding
EZH22_03205	COG0069	glutamate synthase activity
EZH22_03205	COG0067	glutamate synthase
EZH22_03205	COG0070	glutamate synthase
EZH22_03215	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EZH22_03235	COG2967	ApaG domain
EZH22_03240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EZH22_03245	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_03255	COG2217	Heavy metal translocating P-type atpase
EZH22_03270	COG2010	Cytochrome c
EZH22_03285	COG3278	Belongs to the heme-copper respiratory oxidase family
EZH22_03290	COG0842	Transport permease protein
EZH22_03295	COG1131	(ABC) transporter
EZH22_03305	COG1309	transcriptional regulator
EZH22_03315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_03320	COG0728	peptidoglycan biosynthetic process
EZH22_03330	COG0673	inositol 2-dehydrogenase activity
EZH22_03335	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EZH22_03340	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EZH22_03345	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EZH22_03350	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EZH22_03355	COG0322	excinuclease ABC activity
EZH22_03360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EZH22_03370	COG0314	molybdopterin synthase activity
EZH22_03375	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_03395	COG0463	Glycosyl transferase, family 2
EZH22_03400	COG0589	response to stress
EZH22_03410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EZH22_03415	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EZH22_03435	COG0174	glutamine synthetase
EZH22_03440	COG2205	protein histidine kinase activity
EZH22_03445	COG0784	Response regulator, receiver
EZH22_03450	COG0745	RESPONSE REGULATOR receiver
EZH22_03455	COG3411	Ferredoxin
EZH22_03460	COG4150	thiosulfate binding
EZH22_03465	COG0488	(ABC) transporter
EZH22_03480	COG0678	peroxiredoxin activity
EZH22_03490	COG1678	Uncharacterized ACR, COG1678
EZH22_03495	COG3409	Peptidoglycan-binding domain 1 protein
EZH22_03495	COG3773	Cell wall hydrolase
EZH22_03500	COG1703	isobutyryl-CoA mutase activity
EZH22_03515	COG0473	3-isopropylmalate dehydrogenase activity
EZH22_03530	COG0494	nUDIX hydrolase
EZH22_03540	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EZH22_03550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EZH22_03560	COG3842	ATPase activity
EZH22_03565	COG1177	transmembrane transport
EZH22_03570	COG1176	ABC-type spermidine putrescine transport system, permease component I
EZH22_03590	COG2368	4-hydroxyphenylacetate
EZH22_03595	COG0583	DNA-binding transcription factor activity
EZH22_03600	COG3795	YCII-related domain
EZH22_03630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EZH22_03635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZH22_03640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EZH22_03650	COG1902	pentaerythritol trinitrate reductase activity
EZH22_03655	COG0384	phenazine biosynthesis protein PhzF
EZH22_03660	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EZH22_03670	COG0154	amidase activity
EZH22_03680	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EZH22_03705	COG2188	Transcriptional regulator
EZH22_03710	COG3624	Phosphonate C-P lyase system protein PhnG
EZH22_03715	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
EZH22_03720	COG3626	phosphonate metabolism
EZH22_03730	COG4107	phosphonate C-P lyase system protein PhnK
EZH22_03735	COG4778	phosphonate C-P lyase system protein PhnL
EZH22_03740	COG3454	Phosphonate metabolism
EZH22_03745	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EZH22_03765	COG0752	glycyl-tRNA synthetase alpha subunit
EZH22_03775	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EZH22_03785	COG1573	uracil-dna glycosylase
EZH22_03805	COG1525	nuclease
EZH22_03810	COG2202	Pas domain
EZH22_03810	COG2205	protein histidine kinase activity
EZH22_03815	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EZH22_03820	COG1695	Transcriptional regulator
EZH22_03825	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EZH22_03840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZH22_03850	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZH22_03860	COG0567	Dehydrogenase, E1 component
EZH22_03865	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EZH22_03870	COG0045	succinate-CoA ligase (ADP-forming) activity
EZH22_03875	COG0039	L-malate dehydrogenase activity
EZH22_03895	COG0316	Belongs to the HesB IscA family
EZH22_03905	COG0450	alkyl hydroperoxide reductase
EZH22_03910	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZH22_03930	COG4565	transcriptional regulatory protein
EZH22_03935	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
EZH22_03940	COG2086	electron transfer activity
EZH22_03945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EZH22_03950	COG0644	oxidoreductase
EZH22_03955	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EZH22_03965	COG0412	Dienelactone hydrolase
EZH22_03990	COG2346	COG2346, Truncated hemoglobins
EZH22_04020	COG2151	metal-sulfur cluster biosynthetic enzyme
EZH22_04040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EZH22_04055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EZH22_04075	COG5554	nitrogen fixation
EZH22_04095	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EZH22_04115	COG1104	cysteine desulfurase activity
EZH22_04125	COG0316	Belongs to the HesB IscA family
EZH22_04150	COG2897	thiosulfate sulfurtransferase activity
EZH22_04175	COG5420	small protein containing a coiled-coil domain
EZH22_04190	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
EZH22_04195	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
EZH22_04200	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
EZH22_04210	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
EZH22_04215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EZH22_04220	COG0719	Fe-S assembly protein
EZH22_04225	COG0396	ATPase activity
EZH22_04230	COG0719	Fe-S assembly protein
EZH22_04235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EZH22_04250	COG5001	Diguanylate cyclase
EZH22_04250	COG1716	ATPase activity
EZH22_04255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EZH22_04260	COG0756	dUTP diphosphatase activity
EZH22_04290	COG0076	glutamate decarboxylase activity
EZH22_04295	COG0129	dihydroxy-acid dehydratase activity
EZH22_04310	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EZH22_04325	COG1137	ATPase activity
EZH22_04330	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EZH22_04335	COG1764	response to oxidative stress
EZH22_04340	COG1846	Transcriptional regulator
EZH22_04350	COG2205	protein histidine kinase activity
EZH22_04360	COG2226	methyltransferase
EZH22_04365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EZH22_04410	COG0528	UMP kinase activity
EZH22_04415	COG0528	UMP kinase activity
EZH22_04420	COG0521	Mo-molybdopterin cofactor biosynthetic process
EZH22_04425	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EZH22_04440	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EZH22_04450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EZH22_04455	COG1970	mechanosensitive ion channel activity
EZH22_04460	COG0167	dihydroorotate dehydrogenase activity
EZH22_04465	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EZH22_04480	COG0137	argininosuccinate synthase activity
EZH22_04495	COG2217	Heavy metal translocating P-type atpase
EZH22_04525	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_04535	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EZH22_04540	COG1122	ATPase activity
EZH22_04550	COG0129	dihydroxy-acid dehydratase activity
EZH22_04560	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_04565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EZH22_04590	COG2814	Major facilitator Superfamily
EZH22_04605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EZH22_04610	COG0564	pseudouridine synthase activity
EZH22_04630	COG1196	nuclear chromosome segregation
EZH22_04640	COG0356	it plays a direct role in the translocation of protons across the membrane
EZH22_04650	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EZH22_04655	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EZH22_04685	COG2030	dehydratase
EZH22_04695	COG3047	cAMP biosynthetic process
EZH22_04700	COG2009	succinate dehydrogenase
EZH22_04755	COG3119	arylsulfatase activity
EZH22_04760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EZH22_04765	COG4977	sequence-specific DNA binding
EZH22_04790	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EZH22_04805	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EZH22_04810	COG2942	2-epimerase
EZH22_04820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EZH22_04855	COG1309	transcriptional regulator
EZH22_04860	COG1597	lipid kinase activity
EZH22_04865	COG1253	flavin adenine dinucleotide binding
EZH22_04875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZH22_04880	COG0174	glutamine synthetase
EZH22_04890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EZH22_04900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EZH22_04905	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EZH22_04910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EZH22_04915	COG0072	phenylalanine-tRNA ligase activity
EZH22_04915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZH22_04925	COG0006	proline dipeptidase activity
EZH22_04945	COG4251	negative regulation of phosphorylation
EZH22_04945	COG3706	GGDEF domain
EZH22_04945	COG2203	Gaf domain
EZH22_04945	COG5001	Diguanylate cyclase
EZH22_04955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EZH22_04970	COG1741	Belongs to the pirin family
EZH22_04980	COG0366	Alpha amylase catalytic
EZH22_04990	COG2814	Major facilitator Superfamily
EZH22_05010	COG2176	DNA-directed DNA polymerase activity
EZH22_05010	COG5002	protein histidine kinase activity
EZH22_05015	COG0745	RESPONSE REGULATOR receiver
EZH22_05020	COG5002	protein histidine kinase activity
EZH22_05040	COG3162	membrane
EZH22_05050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZH22_05050	COG2080	2 iron, 2 sulfur cluster binding
EZH22_05055	COG3224	Antibiotic biosynthesis monooxygenase
EZH22_05060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_05070	COG0583	DNA-binding transcription factor activity
EZH22_05080	COG0656	L-ascorbic acid biosynthetic process
EZH22_05090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_05100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_05120	COG0583	DNA-binding transcription factor activity
EZH22_05145	COG0284	orotidine-5'-phosphate decarboxylase activity
EZH22_05150	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_05155	COG0402	S-adenosylhomocysteine deaminase activity
EZH22_05170	COG0683	leucine binding
EZH22_05175	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_05205	COG1175	transmembrane transport
EZH22_05215	COG3842	ATPase activity
EZH22_05220	COG1349	DNA-binding transcription factor activity
EZH22_05240	COG1024	Enoyl-CoA hydratase
EZH22_05240	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_05245	COG0183	Belongs to the thiolase family
EZH22_05250	COG1022	Amp-dependent synthetase and ligase
EZH22_05285	COG0625	glutathione transferase activity
EZH22_05290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EZH22_05290	COG0475	glutathione-regulated potassium exporter activity
EZH22_05300	COG0582	viral genome integration into host DNA
EZH22_05310	COG3152	Membrane
EZH22_05355	COG1802	Transcriptional regulator
EZH22_05360	COG1072	(Pantothenic acid kinase))
EZH22_05365	COG0140	phosphoribosyl-ATP diphosphatase activity
EZH22_05370	COG0107	imidazoleglycerol-phosphate synthase activity
EZH22_05375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EZH22_05380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EZH22_05395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EZH22_05400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EZH22_05405	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EZH22_05410	COG2204	response regulator
EZH22_05420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EZH22_05425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EZH22_05430	COG0493	'glutamate synthase
EZH22_05440	COG0523	cobalamin synthesis protein
EZH22_05445	COG1686	Belongs to the peptidase S11 family
EZH22_05450	COG1132	(ABC) transporter
EZH22_05455	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EZH22_05460	COG0594	ribonuclease P activity
EZH22_05465	COG0706	membrane insertase activity
EZH22_05470	COG0156	8-amino-7-oxononanoate synthase activity
EZH22_05495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EZH22_05500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EZH22_05570	COG0375	protein maturation
EZH22_05580	COG2204	response regulator
EZH22_05620	COG0539	negative regulation of cytoplasmic translation
EZH22_05635	COG5487	UPF0391 membrane protein
EZH22_05655	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EZH22_05670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EZH22_05690	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_05695	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_05700	COG1764	response to oxidative stress
EZH22_05720	COG4191	Histidine kinase
EZH22_05725	COG4566	intracellular signal transduction
EZH22_05745	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
EZH22_05765	COG3052	prosthetic group binding
EZH22_05780	COG0679	Auxin Efflux Carrier
EZH22_05785	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_05790	COG1802	Transcriptional regulator
EZH22_05795	COG0583	DNA-binding transcription factor activity
EZH22_05805	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_05815	COG0183	Belongs to the thiolase family
EZH22_05830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_05835	COG1309	transcriptional regulator
EZH22_05855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EZH22_05860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EZH22_05900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_06050	COG3739	integral membrane protein
EZH22_06105	COG1522	sequence-specific DNA binding
EZH22_06115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_06120	COG1129	ABC transporter
EZH22_06120	COG0842	Transport permease protein
EZH22_06130	COG1959	2 iron, 2 sulfur cluster binding
EZH22_06135	COG2917	probably involved in intracellular septation
EZH22_06155	COG0745	RESPONSE REGULATOR receiver
EZH22_06160	COG0704	Plays a role in the regulation of phosphate uptake
EZH22_06165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EZH22_06175	COG0573	inorganic phosphate transmembrane transporter activity
EZH22_06185	COG5002	protein histidine kinase activity
EZH22_06250	COG3158	transport of potassium into the cell
EZH22_06255	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EZH22_06285	COG1278	Cold shock
EZH22_06295	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EZH22_06310	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EZH22_06315	COG0482	sulfurtransferase activity
EZH22_06320	COG2226	methyltransferase
EZH22_06345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZH22_06350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_06360	COG3264	Mechanosensitive ion channel
EZH22_06360	COG1196	nuclear chromosome segregation
EZH22_06365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EZH22_06375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EZH22_06395	COG1960	acyl-CoA dehydrogenase activity
EZH22_06420	COG0588	phosphoglycerate mutase activity
EZH22_06435	COG0284	orotidine-5'-phosphate decarboxylase activity
EZH22_06445	COG3963	phosphatidate phosphatase activity
EZH22_06460	COG0484	heat shock protein binding
EZH22_06470	COG0443	Heat shock 70 kDa protein
EZH22_06495	COG4191	Histidine kinase
EZH22_06500	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
EZH22_06515	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EZH22_06520	COG0792	nuclease activity
EZH22_06525	COG0189	ligase activity
EZH22_06535	COG2226	methyltransferase
EZH22_06560	COG0497	DNA recombination
EZH22_06565	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZH22_06575	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EZH22_06580	COG0849	cell division
EZH22_06585	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EZH22_06595	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EZH22_06600	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EZH22_06615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_06625	COG3395	kinase activity
EZH22_06630	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EZH22_06660	COG0702	epimerase
EZH22_06690	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EZH22_06715	COG0436	Aminotransferase
EZH22_06735	COG0779	Required for maturation of 30S ribosomal subunits
EZH22_06750	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EZH22_06755	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EZH22_06760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EZH22_06765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EZH22_06770	COG1185	polyribonucleotide nucleotidyltransferase activity
EZH22_06805	COG4689	acetoacetate decarboxylase
EZH22_06820	COG1607	acyl-coa hydrolase
EZH22_06825	COG1643	Atp-dependent helicase
EZH22_06830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EZH22_06835	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EZH22_06840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZH22_06845	COG0494	nUDIX hydrolase
EZH22_06850	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EZH22_06880	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EZH22_06940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EZH22_06975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EZH22_06990	COG0427	acetyl-CoA hydrolase
EZH22_06995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EZH22_07030	COG1850	ribulose-bisphosphate carboxylase activity
EZH22_07040	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EZH22_07050	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EZH22_07055	COG4149	molybdate abc transporter
EZH22_07065	COG1609	Transcriptional regulator
EZH22_07090	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_07095	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EZH22_07100	COG2086	electron transfer activity
EZH22_07120	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
EZH22_07135	COG0247	lactate metabolic process
EZH22_07140	COG1139	Iron-sulfur cluster binding protein
EZH22_07145	COG1556	Lactate utilization protein
EZH22_07165	COG0583	DNA-binding transcription factor activity
EZH22_07170	COG0277	FAD linked oxidase domain protein
EZH22_07180	COG0247	lactate metabolic process
EZH22_07185	COG0352	thiamine-phosphate diphosphorylase activity
EZH22_07190	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EZH22_07200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EZH22_07200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EZH22_07205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EZH22_07215	COG3300	MHYT domain
EZH22_07215	COG5001	Diguanylate cyclase
EZH22_07220	COG0045	succinate-CoA ligase (ADP-forming) activity
EZH22_07220	COG1042	CoA-binding domain protein
EZH22_07220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZH22_07225	COG4566	intracellular signal transduction
EZH22_07230	COG4566	intracellular signal transduction
EZH22_07235	COG4191	Histidine kinase
EZH22_07240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZH22_07245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EZH22_07290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZH22_07300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_07345	COG0138	bifunctional purine biosynthesis protein purh
EZH22_07355	COG1215	transferase activity, transferring glycosyl groups
EZH22_07370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZH22_07375	COG0165	Argininosuccinate lyase
EZH22_07380	COG0019	diaminopimelate decarboxylase activity
EZH22_07385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EZH22_07390	COG0501	Belongs to the peptidase M48B family
EZH22_07400	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
EZH22_07430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EZH22_07495	COG0702	epimerase
EZH22_07525	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
EZH22_07530	COG1229	Formylmethanofuran dehydrogenase subunit A
EZH22_07550	COG0535	radical SAM domain protein
EZH22_07555	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
EZH22_07560	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
EZH22_07565	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EZH22_07585	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EZH22_07595	COG1968	undecaprenyl-diphosphatase activity
EZH22_07605	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EZH22_07610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EZH22_07615	COG1702	phosphate starvation-inducible protein PhoH
EZH22_07620	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EZH22_07625	COG1253	flavin adenine dinucleotide binding
EZH22_07630	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EZH22_07635	COG1396	sequence-specific DNA binding
EZH22_07640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EZH22_07645	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EZH22_07675	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EZH22_07680	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EZH22_07685	COG1981	membrane
EZH22_07690	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EZH22_07695	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EZH22_07700	COG0424	maF-like protein
EZH22_07705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EZH22_07710	COG0237	dephospho-CoA kinase activity
EZH22_07715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EZH22_07720	COG1331	Highly conserved protein containing a thioredoxin domain
EZH22_07725	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EZH22_07730	COG0445	tRNA wobble uridine modification
EZH22_07735	COG0357	Ribosomal RNA small subunit methyltransferase G
EZH22_07755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EZH22_07760	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EZH22_07770	COG0436	Aminotransferase
EZH22_07775	COG0196	riboflavin kinase activity
EZH22_07785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EZH22_07795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EZH22_07805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EZH22_07815	COG0275	rRNA processing
EZH22_07820	COG2001	Belongs to the MraZ family
EZH22_07830	COG2274	protein secretion by the type I secretion system
EZH22_07835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZH22_07855	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EZH22_07865	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_07885	COG0564	pseudouridine synthase activity
EZH22_07895	COG5001	Diguanylate cyclase
EZH22_07895	COG3300	MHYT domain
EZH22_07905	COG0330	HflC and HflK could
EZH22_07935	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EZH22_07970	COG4181	ATPase activity
EZH22_08005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZH22_08010	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EZH22_08025	COG3023	N-Acetylmuramoyl-L-alanine amidase
EZH22_08030	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EZH22_08060	COG0542	response to heat
EZH22_08080	COG0739	heme binding
EZH22_08115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EZH22_08115	COG0519	Catalyzes the synthesis of GMP from XMP
EZH22_08120	COG0697	spore germination
EZH22_08125	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_08140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EZH22_08140	COG2813	Specifically methylates the guanine in position
EZH22_08150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZH22_08175	COG0784	Response regulator, receiver
EZH22_08185	COG0784	Response regulator, receiver
EZH22_08185	COG4191	Histidine kinase
EZH22_08210	COG0069	glutamate synthase activity
EZH22_08225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZH22_08230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EZH22_08240	COG3038	cytochrome b561
EZH22_08245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZH22_08245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZH22_08260	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EZH22_08270	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EZH22_08275	COG0268	Binds directly to 16S ribosomal RNA
EZH22_08285	COG0135	phosphoribosylanthranilate isomerase activity
EZH22_08290	COG0133	tryptophan synthase activity
EZH22_08300	COG0159	tryptophan synthase activity
EZH22_08305	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EZH22_08315	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EZH22_08320	COG2884	Cell division ATP-binding protein ftsE
EZH22_08355	COG3454	Phosphonate metabolism
EZH22_08365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EZH22_08375	COG0670	Belongs to the BI1 family
EZH22_08390	COG0583	DNA-binding transcription factor activity
EZH22_08395	COG0837	glucose binding
EZH22_08405	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EZH22_08435	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EZH22_08445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EZH22_08460	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EZH22_08465	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EZH22_08470	COG0799	negative regulation of ribosome biogenesis
EZH22_08475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EZH22_08480	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EZH22_08500	COG3750	Belongs to the UPF0335 family
EZH22_08505	COG3108	Peptidase M15
EZH22_08510	COG2989	Protein conserved in bacteria
EZH22_08515	COG0745	RESPONSE REGULATOR receiver
EZH22_08530	COG0793	Belongs to the peptidase S41A family
EZH22_08535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_08540	COG0765	amino acid transport
EZH22_08545	COG0765	amino acid transport
EZH22_08555	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EZH22_08560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EZH22_08565	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EZH22_08570	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EZH22_08580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EZH22_08585	COG0590	tRNA wobble adenosine to inosine editing
EZH22_08590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZH22_08605	COG1116	anion transmembrane transporter activity
EZH22_08610	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EZH22_08620	COG2855	membrane
EZH22_08630	COG0488	(ABC) transporter
EZH22_08635	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EZH22_08640	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EZH22_08650	COG0509	glycine decarboxylation via glycine cleavage system
EZH22_08655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EZH22_08665	COG0612	Peptidase, M16
EZH22_08670	COG0612	Peptidase, M16
EZH22_08680	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EZH22_08685	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EZH22_08690	COG0004	ammonium transporteR
EZH22_08695	COG0347	Belongs to the P(II) protein family
EZH22_08705	COG1946	Acyl-CoA thioesterase
EZH22_08710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_08715	COG2835	tetraacyldisaccharide 4'-kinase activity
EZH22_08720	COG0697	spore germination
EZH22_08725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EZH22_08740	COG4208	sulfate ABC transporter
EZH22_08750	COG0776	regulation of translation
EZH22_08755	COG0616	signal peptide processing
EZH22_08770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZH22_08770	COG2022	thiamine diphosphate biosynthetic process
EZH22_08780	COG2022	thiamine diphosphate biosynthetic process
EZH22_08785	COG0352	thiamine-phosphate diphosphorylase activity
EZH22_08790	COG2183	response to ionizing radiation
EZH22_08815	COG1301	dicarboxylic acid transport
EZH22_08820	COG4191	Histidine kinase
EZH22_08825	COG2204	response regulator
EZH22_08830	COG0129	dihydroxy-acid dehydratase activity
EZH22_08835	COG0625	glutathione transferase activity
EZH22_08850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EZH22_08860	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EZH22_08865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EZH22_08870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EZH22_08875	COG0640	Transcriptional regulator
EZH22_08885	COG1393	Belongs to the ArsC family
EZH22_08890	COG0798	PFAM Bile acid sodium symporter
EZH22_08895	COG0431	NADPH-dependent FMN reductase
EZH22_08925	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_08935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EZH22_08975	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EZH22_08980	COG0076	glutamate decarboxylase activity
EZH22_08990	COG1960	acyl-CoA dehydrogenase activity
EZH22_08995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EZH22_09005	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EZH22_09010	COG4670	ketone body catabolic process
EZH22_09015	COG1024	Enoyl-CoA hydratase
EZH22_09020	COG3976	FMN-binding domain protein
EZH22_09020	COG1053	succinate dehydrogenase
EZH22_09040	COG1136	(ABC) transporter
EZH22_09050	COG1760	l-serine dehydratase
EZH22_09060	COG0446	pyridine nucleotide-disulphide oxidoreductase
EZH22_09060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EZH22_09070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZH22_09095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_09100	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EZH22_09125	COG2226	methyltransferase
EZH22_09160	COG1846	Transcriptional regulator
EZH22_09165	COG0410	ABC transporter
EZH22_09205	COG2080	2 iron, 2 sulfur cluster binding
EZH22_09210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZH22_09210	COG2010	Cytochrome c
EZH22_09255	COG4566	intracellular signal transduction
EZH22_09265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZH22_09270	COG4191	Histidine kinase
EZH22_09275	COG4566	intracellular signal transduction
EZH22_09280	COG2140	Oxalate decarboxylase
EZH22_09305	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_09315	COG4191	Histidine kinase
EZH22_09325	COG2223	nitrite transmembrane transporter activity
EZH22_09330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EZH22_09360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_09365	COG1802	Transcriptional regulator
EZH22_09370	COG0765	amino acid transport
EZH22_09375	COG1126	abc transporter atp-binding protein
EZH22_09395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EZH22_09400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EZH22_09410	COG1414	Transcriptional regulator
EZH22_09415	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_09420	COG0183	Belongs to the thiolase family
EZH22_09430	COG4829	muconolactone delta-isomerase
EZH22_09440	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EZH22_09465	COG4191	Histidine kinase
EZH22_09470	COG4566	intracellular signal transduction
EZH22_09480	COG1116	anion transmembrane transporter activity
EZH22_09490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZH22_09520	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EZH22_09525	COG0038	chloride channel
EZH22_09530	COG4178	(ABC) transporter
EZH22_09540	COG2824	Alkylphosphonate utilization operon protein PhnA
EZH22_09545	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_09565	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EZH22_09575	COG2135	peptidase activity
EZH22_09585	COG0546	phosphoglycolate phosphatase activity
EZH22_09595	COG1388	LysM domain
EZH22_09595	COG1376	ErfK ybiS ycfS ynhG family protein
EZH22_09615	COG0259	pyridoxamine-phosphate oxidase activity
EZH22_09625	COG0484	heat shock protein binding
EZH22_09630	COG2030	dehydratase
EZH22_09655	COG1024	Enoyl-CoA hydratase
EZH22_09665	COG0730	response to heat
EZH22_09685	COG3237	CsbD-like
EZH22_09690	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EZH22_09695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EZH22_09700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EZH22_09705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EZH22_09735	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_09740	COG1802	Transcriptional regulator
EZH22_09755	COG1129	ABC transporter
EZH22_09760	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_09765	COG3246	L-lysine catabolic process to acetate
EZH22_09780	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EZH22_09805	COG0335	large ribosomal subunit rRNA binding
EZH22_09810	COG0336	Belongs to the RNA methyltransferase TrmD family
EZH22_09815	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EZH22_09835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EZH22_09840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZH22_09845	COG0277	FAD linked oxidase domain protein
EZH22_09850	COG2271	Major facilitator Superfamily
EZH22_09855	COG2208	phosphoserine phosphatase activity
EZH22_09855	COG2770	Histidine kinase
EZH22_09905	COG1366	Belongs to the anti-sigma-factor antagonist family
EZH22_09910	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EZH22_09915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EZH22_09930	COG1420	regulation of RNA biosynthetic process
EZH22_09935	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EZH22_09940	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EZH22_09945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EZH22_09950	COG1160	GTP binding
EZH22_09965	COG1671	Belongs to the UPF0178 family
EZH22_09970	COG0671	phosphoesterase, PA-phosphatase related
EZH22_09990	COG1496	oxidoreductase activity
EZH22_10020	COG0617	tRNA 3'-terminal CCA addition
EZH22_10035	COG0640	Transcriptional regulator
EZH22_10065	COG3047	cAMP biosynthetic process
EZH22_10075	COG1063	alcohol dehydrogenase
EZH22_10165	COG1309	transcriptional regulator
EZH22_10180	COG2267	carboxylic ester hydrolase activity
EZH22_10195	COG0427	acetyl-CoA hydrolase
EZH22_10200	COG3246	L-lysine catabolic process to acetate
EZH22_10205	COG2072	flavoprotein involved in K transport
EZH22_10225	COG1024	Enoyl-CoA hydratase
EZH22_10235	COG1024	Enoyl-CoA hydratase
EZH22_10260	COG1137	ATPase activity
EZH22_10270	COG1024	Enoyl-CoA hydratase
EZH22_10280	COG1960	acyl-CoA dehydrogenase activity
EZH22_10285	COG1960	acyl-CoA dehydrogenase activity
EZH22_10290	COG2030	dehydratase
EZH22_10295	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_10310	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_10320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_10325	COG1960	acyl-CoA dehydrogenase activity
EZH22_10330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_10335	COG2186	Transcriptional regulator
EZH22_10340	COG2186	Transcriptional regulator
EZH22_10370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_10410	COG3485	protocatechuate 3,4-dioxygenase
EZH22_10415	COG3485	protocatechuate 3,4-dioxygenase
EZH22_10420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZH22_10425	COG0583	DNA-binding transcription factor activity
EZH22_10470	COG1024	Enoyl-CoA hydratase
EZH22_10500	COG0667	Aldo Keto reductase
EZH22_10505	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_10550	COG1309	transcriptional regulator
EZH22_10555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZH22_10560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_10565	COG0386	Belongs to the glutathione peroxidase family
EZH22_10580	COG1283	sodium-dependent phosphate transmembrane transporter activity
EZH22_10585	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EZH22_10605	COG0647	UMP catabolic process
EZH22_10610	COG1737	Transcriptional regulator
EZH22_10640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EZH22_10670	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EZH22_10710	COG4372	Transposase
EZH22_10715	COG3436	PFAM IS66 Orf2 family protein
EZH22_10720	COG2963	transposase activity
EZH22_10735	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EZH22_10805	COG0582	viral genome integration into host DNA
EZH22_10815	COG1024	Enoyl-CoA hydratase
EZH22_10820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EZH22_10830	COG0242	peptide deformylase activity
EZH22_10835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EZH22_10840	COG0101	tRNA pseudouridine synthase activity
EZH22_10855	COG0778	Nitroreductase
EZH22_10865	COG4221	oxidoreductase activity
EZH22_10870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EZH22_10885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EZH22_10920	COG0071	Belongs to the small heat shock protein (HSP20) family
EZH22_10925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZH22_10945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_10965	COG2226	methyltransferase
EZH22_11000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_11040	COG1999	signal sequence binding
EZH22_11055	COG0679	Auxin Efflux Carrier
EZH22_11060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EZH22_11070	COG0400	carboxylic ester hydrolase activity
EZH22_11105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EZH22_11110	COG1846	Transcriptional regulator
EZH22_11115	COG0745	RESPONSE REGULATOR receiver
EZH22_11125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EZH22_11135	COG2818	Glycosylase
EZH22_11150	COG2890	protein-(glutamine-N5) methyltransferase activity
EZH22_11155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EZH22_11165	COG0527	aspartate kinase activity
EZH22_11175	COG2816	NAD+ diphosphatase activity
EZH22_11195	COG3474	cytochrome
EZH22_11200	COG4166	transmembrane transport
EZH22_11210	COG4174	ABC transporter (Permease)
EZH22_11215	COG4239	(ABC) transporter, permease
EZH22_11220	COG4172	Belongs to the ABC transporter superfamily
EZH22_11225	COG0494	nUDIX hydrolase
EZH22_11365	COG3842	ATPase activity
EZH22_11370	COG1176	ABC-type spermidine putrescine transport system, permease component I
EZH22_11375	COG1177	transmembrane transport
EZH22_11400	COG0714	Associated with various cellular activities
EZH22_11420	COG0617	tRNA 3'-terminal CCA addition
EZH22_11440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EZH22_11450	COG0723	plastoquinol--plastocyanin reductase activity
EZH22_11455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EZH22_11455	COG2857	Cytochrome c1
EZH22_11460	COG2857	Cytochrome c1
EZH22_11460	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EZH22_11470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EZH22_11485	COG3706	GGDEF domain
EZH22_11500	COG2983	Belongs to the UPF0260 family
EZH22_11530	COG1217	gtp-binding protein TYPA
EZH22_11535	COG2084	Dehydrogenase
EZH22_11540	COG3622	Belongs to the hyi family
EZH22_11545	COG3960	tartronate-semialdehyde synthase activity
EZH22_11555	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EZH22_11560	COG0450	alkyl hydroperoxide reductase
EZH22_11565	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EZH22_11565	COG0617	tRNA 3'-terminal CCA addition
EZH22_11565	COG3620	sequence-specific DNA binding
EZH22_11610	COG1609	Transcriptional regulator
EZH22_11655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EZH22_11680	COG2081	HI0933 family
EZH22_11690	COG0469	pyruvate kinase activity
EZH22_11695	COG2954	triphosphatase activity
EZH22_11715	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_11720	COG1960	acyl-CoA dehydrogenase activity
EZH22_11725	COG1024	Enoyl-CoA hydratase
EZH22_11780	COG0436	Aminotransferase
EZH22_11790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EZH22_11795	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EZH22_11800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EZH22_11825	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZH22_11830	COG4957	zinc ion binding
EZH22_11835	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EZH22_11855	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EZH22_11890	COG1475	DNA binding
EZH22_11920	COG5489	Protein of unknown function (DUF736)
EZH22_11925	COG1396	sequence-specific DNA binding
EZH22_11945	COG1192	Involved in chromosome partitioning
EZH22_11965	COG1196	nuclear chromosome segregation
EZH22_11965	COG0741	lytic transglycosylase activity
EZH22_11965	COG0739	heme binding
EZH22_12030	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EZH22_12055	COG4962	Type ii secretion system protein e
EZH22_12070	COG3451	type IV secretory pathway VirB4
EZH22_12090	COG3701	Conjugal transfer protein
EZH22_12100	COG2948	multi-organism process
EZH22_12110	COG0583	DNA-binding transcription factor activity
EZH22_12115	COG2301	Belongs to the HpcH HpaI aldolase family
EZH22_12120	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
EZH22_12130	COG1960	acyl-CoA dehydrogenase activity
EZH22_12180	COG0583	DNA-binding transcription factor activity
EZH22_12200	COG4974	Belongs to the 'phage' integrase family
EZH22_12220	COG1053	succinate dehydrogenase
EZH22_12220	COG3976	FMN-binding domain protein
EZH22_12225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_12235	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_12270	COG0583	DNA-binding transcription factor activity
EZH22_12285	COG2706	6-phosphogluconolactonase activity
EZH22_12290	COG3177	Filamentation induced by cAMP protein fic
EZH22_12300	COG0583	DNA-binding transcription factor activity
EZH22_12325	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_12335	COG4336	lyase activity
EZH22_12340	COG0519	Catalyzes the synthesis of GMP from XMP
EZH22_12340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EZH22_12375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_12385	COG0183	Belongs to the thiolase family
EZH22_12390	COG1024	Enoyl-CoA hydratase
EZH22_12390	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_12415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_12425	COG0747	negative chemotaxis
EZH22_12430	COG0601	transmembrane transport
EZH22_12435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZH22_12450	COG0667	Aldo Keto reductase
EZH22_12455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_12460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_12480	COG1116	anion transmembrane transporter activity
EZH22_12485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_12490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_12505	COG1136	(ABC) transporter
EZH22_12550	COG2030	dehydratase
EZH22_12555	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_12560	COG2050	protein possibly involved in aromatic compounds catabolism
EZH22_12565	COG1309	transcriptional regulator
EZH22_12570	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_12575	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EZH22_12595	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_12595	COG1024	Enoyl-CoA hydratase
EZH22_12600	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_12605	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_12635	COG1960	acyl-CoA dehydrogenase activity
EZH22_12640	COG1024	Enoyl-CoA hydratase
EZH22_12645	COG1024	Enoyl-CoA hydratase
EZH22_12650	COG0604	alcohol dehydrogenase
EZH22_12655	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_12660	COG1846	Transcriptional regulator
EZH22_12670	COG1960	acyl-CoA dehydrogenase activity
EZH22_12675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EZH22_12680	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_12685	COG1960	acyl-CoA dehydrogenase activity
EZH22_12690	COG0183	Belongs to the thiolase family
EZH22_12715	COG0431	NADPH-dependent FMN reductase
EZH22_12715	COG3976	FMN-binding domain protein
EZH22_12715	COG1053	succinate dehydrogenase
EZH22_12750	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_12780	COG2084	Dehydrogenase
EZH22_12790	COG1902	pentaerythritol trinitrate reductase activity
EZH22_12790	COG0446	pyridine nucleotide-disulphide oxidoreductase
EZH22_12805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_12835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_12855	COG1960	acyl-CoA dehydrogenase activity
EZH22_12860	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_12865	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_12875	COG2368	4-hydroxyphenylacetate
EZH22_12900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_12905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_12955	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EZH22_12975	COG1522	sequence-specific DNA binding
EZH22_12980	COG2199	diguanylate cyclase activity
EZH22_12980	COG2203	Gaf domain
EZH22_12985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_13000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_13005	COG1116	anion transmembrane transporter activity
EZH22_13010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_13015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_13020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_13035	COG0646	methionine synthase
EZH22_13035	COG1410	methionine synthase
EZH22_13040	COG1376	ErfK ybiS ycfS ynhG family protein
EZH22_13055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EZH22_13060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EZH22_13090	COG2351	hydroxyisourate hydrolase activity
EZH22_13095	COG2233	PERMEase
EZH22_13100	COG0583	DNA-binding transcription factor activity
EZH22_13115	COG2205	protein histidine kinase activity
EZH22_13120	COG3178	'Phosphotransferase
EZH22_13125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EZH22_13135	COG1074	ATP-dependent DNA helicase activity
EZH22_13145	COG0579	oxidoreductase
EZH22_13150	COG3842	ATPase activity
EZH22_13155	COG1178	ABC-type Fe3 transport system permease component
EZH22_13165	COG0028	Belongs to the TPP enzyme family
EZH22_13170	COG1960	acyl-CoA dehydrogenase activity
EZH22_13175	COG2030	dehydratase
EZH22_13185	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EZH22_13190	COG0583	DNA-binding transcription factor activity
EZH22_13205	COG1136	(ABC) transporter
EZH22_13205	COG0577	efflux transmembrane transporter activity
EZH22_13210	COG2205	protein histidine kinase activity
EZH22_13220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_13235	COG0242	peptide deformylase activity
EZH22_13255	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_13260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZH22_13260	COG3453	Protein conserved in bacteria
EZH22_13290	COG0488	(ABC) transporter
EZH22_13300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EZH22_13305	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EZH22_13315	COG1024	Enoyl-CoA hydratase
EZH22_13320	COG2084	Dehydrogenase
EZH22_13325	COG1902	pentaerythritol trinitrate reductase activity
EZH22_13330	COG1309	transcriptional regulator
EZH22_13335	COG4670	ketone body catabolic process
EZH22_13355	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EZH22_13360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_13365	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_13370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_13375	COG1136	(ABC) transporter
EZH22_13375	COG0577	efflux transmembrane transporter activity
EZH22_13380	COG0577	efflux transmembrane transporter activity
EZH22_13385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_13390	COG3321	synthase
EZH22_13390	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_13390	COG0604	alcohol dehydrogenase
EZH22_13405	COG2010	Cytochrome c
EZH22_13415	COG2951	lytic endotransglycosylase activity
EZH22_13420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EZH22_13440	COG0287	Prephenate dehydrogenase
EZH22_13445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EZH22_13475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EZH22_13495	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EZH22_13510	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EZH22_13515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EZH22_13520	COG0552	protein localization to endoplasmic reticulum
EZH22_13545	COG2943	transferase activity, transferring hexosyl groups
EZH22_13560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EZH22_13565	COG0583	DNA-binding transcription factor activity
EZH22_13570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EZH22_13575	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EZH22_13590	COG0861	Integral membrane protein TerC family
EZH22_13595	COG0861	Integral membrane protein TerC family
EZH22_13600	COG0105	UTP biosynthetic process
EZH22_13610	COG0667	Aldo Keto reductase
EZH22_13620	COG2030	dehydratase
EZH22_13630	COG0012	GTP binding
EZH22_13635	COG0193	aminoacyl-tRNA hydrolase activity
EZH22_13640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EZH22_13645	COG3258	Cytochrome c
EZH22_13655	COG1309	transcriptional regulator
EZH22_13670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EZH22_13685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_13690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_13695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_13695	COG1116	anion transmembrane transporter activity
EZH22_13700	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EZH22_13705	COG0778	Nitroreductase
EZH22_13720	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_13725	COG1648	precorrin-2 dehydrogenase activity
EZH22_13725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EZH22_13730	COG0251	oxidation-reduction process
EZH22_13740	COG0246	Mannitol dehydrogenase
EZH22_13745	COG1904	glucuronate isomerase
EZH22_13755	COG2721	sulfolactate sulfo-lyase activity
EZH22_13760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EZH22_13775	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EZH22_13780	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_13790	COG1872	DUF167
EZH22_13800	COG0825	malonyl-CoA metabolic process
EZH22_13805	COG3034	peptidoglycan biosynthetic process
EZH22_13815	COG0653	protein targeting
EZH22_13820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_13835	COG2307	Protein conserved in bacteria
EZH22_13835	COG2308	Evidence 4 Homologs of previously reported genes of
EZH22_13840	COG1305	Transglutaminase-like
EZH22_13845	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_13855	COG2186	Transcriptional regulator
EZH22_13860	COG0745	RESPONSE REGULATOR receiver
EZH22_13875	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZH22_13875	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZH22_13885	COG3852	Histidine kinase
EZH22_13905	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EZH22_13920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZH22_13930	COG4608	Belongs to the ABC transporter superfamily
EZH22_13935	COG0444	Belongs to the ABC transporter superfamily
EZH22_13945	COG0601	transmembrane transport
EZH22_13950	COG4166	transmembrane transport
EZH22_14115	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_14130	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_14140	COG1122	ATPase activity
EZH22_14155	COG1960	acyl-CoA dehydrogenase activity
EZH22_14160	COG1024	Enoyl-CoA hydratase
EZH22_14180	COG2030	dehydratase
EZH22_14190	COG1137	ATPase activity
EZH22_14220	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZH22_14225	COG1024	Enoyl-CoA hydratase
EZH22_14230	COG0022	dehydrogenase e1 component
EZH22_14235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EZH22_14245	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_14280	COG2207	Transcriptional regulator
EZH22_14300	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_14305	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_14315	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_14320	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_14335	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_14350	COG1309	transcriptional regulator
EZH22_14355	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_14360	COG0183	Belongs to the thiolase family
EZH22_14380	COG0411	ABC transporter
EZH22_14390	COG0667	Aldo Keto reductase
EZH22_14395	COG0534	Mate efflux family protein
EZH22_14410	COG0174	glutamine synthetase
EZH22_14415	COG0519	Catalyzes the synthesis of GMP from XMP
EZH22_14425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EZH22_14430	COG1960	acyl-CoA dehydrogenase activity
EZH22_14450	COG2205	protein histidine kinase activity
EZH22_14455	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EZH22_14460	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EZH22_14470	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EZH22_14510	COG3327	negative regulation of DNA-templated transcription, initiation
EZH22_14515	COG3396	Phenylacetate-CoA oxygenase
EZH22_14520	COG3460	Phenylacetate-CoA oxygenase
EZH22_14525	COG3396	Phenylacetate-CoA oxygenase
EZH22_14530	COG2151	metal-sulfur cluster biosynthetic enzyme
EZH22_14535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EZH22_14545	COG2050	protein possibly involved in aromatic compounds catabolism
EZH22_14550	COG1024	Enoyl-CoA hydratase
EZH22_14560	COG0183	Belongs to the thiolase family
EZH22_14570	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_14570	COG2030	dehydratase
EZH22_14580	COG2814	Major facilitator Superfamily
EZH22_14585	COG0583	DNA-binding transcription factor activity
EZH22_14630	COG0650	Formate hydrogenlyase subunit 4
EZH22_14640	COG0651	ATP synthesis coupled electron transport
EZH22_14645	COG3261	NADH dehydrogenase
EZH22_14645	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
EZH22_14650	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZH22_14655	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_14660	COG3284	Transcriptional regulator
EZH22_14700	COG0154	amidase activity
EZH22_14710	COG2368	4-hydroxyphenylacetate
EZH22_14715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_14745	COG0175	sulfate reduction
EZH22_14755	COG0556	nucleotide-excision repair
EZH22_14780	COG2133	pyrroloquinoline quinone binding
EZH22_14790	COG0625	glutathione transferase activity
EZH22_14795	COG0436	Aminotransferase
EZH22_14815	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EZH22_14835	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EZH22_14840	COG0625	glutathione transferase activity
EZH22_14855	COG0500	methyltransferase
EZH22_14865	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EZH22_14870	COG0424	maF-like protein
EZH22_14880	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EZH22_14880	COG1618	nucleotide phosphatase activity, acting on free nucleotides
EZH22_14885	COG2271	Major facilitator Superfamily
EZH22_14905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EZH22_14910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EZH22_14915	COG1522	sequence-specific DNA binding
EZH22_14920	COG0492	ferredoxin-NADP+ reductase activity
EZH22_14935	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
EZH22_14965	COG1921	L-seryl-tRNASec selenium transferase activity
EZH22_14975	COG2864	formate dehydrogenase
EZH22_14980	COG0437	4 iron, 4 sulfur cluster binding
EZH22_14990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZH22_15000	COG0709	Synthesizes selenophosphate from selenide and ATP
EZH22_15015	COG1063	alcohol dehydrogenase
EZH22_15040	COG2610	gluconate transmembrane transporter activity
EZH22_15045	COG0786	glutamate:sodium symporter activity
EZH22_15065	COG0151	Belongs to the GarS family
EZH22_15070	COG1570	exodeoxyribonuclease VII activity
EZH22_15080	COG1663	tetraacyldisaccharide 4'-kinase activity
EZH22_15105	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EZH22_15115	COG0028	Belongs to the TPP enzyme family
EZH22_15125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EZH22_15130	COG0716	FMN binding
EZH22_15145	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EZH22_15155	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EZH22_15170	COG3321	synthase
EZH22_15170	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_15170	COG0604	alcohol dehydrogenase
EZH22_15185	COG0254	rRNA binding
EZH22_15190	COG1132	(ABC) transporter
EZH22_15220	COG0673	inositol 2-dehydrogenase activity
EZH22_15225	COG3842	ATPase activity
EZH22_15245	COG0129	dihydroxy-acid dehydratase activity
EZH22_15265	COG2201	protein-glutamate methylesterase activity
EZH22_15275	COG4178	(ABC) transporter
EZH22_15280	COG1278	Cold shock
EZH22_15300	COG3459	Glycosyltransferase 36 associated
EZH22_15320	COG0583	DNA-binding transcription factor activity
EZH22_15330	COG0625	glutathione transferase activity
EZH22_15345	COG0583	DNA-binding transcription factor activity
EZH22_15380	COG0281	malic enzyme
EZH22_15400	COG0277	FAD linked oxidase domain protein
EZH22_15420	COG2010	Cytochrome c
EZH22_15420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZH22_15460	COG3842	ATPase activity
EZH22_15465	COG0243	molybdopterin cofactor binding
EZH22_15495	COG0583	DNA-binding transcription factor activity
EZH22_15510	COG1388	LysM domain
EZH22_15510	COG1376	ErfK ybiS ycfS ynhG family protein
EZH22_15530	COG0519	Catalyzes the synthesis of GMP from XMP
EZH22_15530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EZH22_15625	COG0154	amidase activity
EZH22_15630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_15640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_15645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_15665	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_15670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EZH22_15715	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EZH22_15735	COG0420	3'-5' exonuclease activity
EZH22_15755	COG2373	Large extracellular alpha-helical protein
EZH22_15760	COG4953	penicillin-binding protein 1C
EZH22_15775	COG0582	viral genome integration into host DNA
EZH22_15815	COG1960	acyl-CoA dehydrogenase activity
EZH22_15830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_15850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_15860	COG3386	PFAM SMP-30 Gluconolaconase
EZH22_15865	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_15880	COG4232	protein-disulfide reductase activity
EZH22_15890	COG1388	LysM domain
EZH22_15890	COG1376	ErfK ybiS ycfS ynhG family protein
EZH22_15905	COG0765	amino acid transport
EZH22_15910	COG0765	amino acid transport
EZH22_15915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_15920	COG1414	Transcriptional regulator
EZH22_15935	COG0765	amino acid transport
EZH22_15940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_15955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EZH22_15960	COG0235	Class ii aldolase
EZH22_15980	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_15990	COG1404	Belongs to the peptidase S8 family
EZH22_16030	COG0604	alcohol dehydrogenase
EZH22_16050	COG0577	efflux transmembrane transporter activity
EZH22_16055	COG1136	(ABC) transporter
EZH22_16085	COG1032	radical SAM domain protein
EZH22_16130	COG0583	DNA-binding transcription factor activity
EZH22_16145	COG1414	Transcriptional regulator
EZH22_16155	COG0477	Major facilitator Superfamily
EZH22_16160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EZH22_16180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EZH22_16195	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EZH22_16205	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EZH22_16210	COG0081	regulation of translation
EZH22_16215	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EZH22_16220	COG0222	ribosome binding
EZH22_16225	COG0085	RNA polymerase activity
EZH22_16230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EZH22_16240	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
EZH22_16285	COG0142	geranyltranstransferase activity
EZH22_16315	COG1742	UPF0060 membrane protein
EZH22_16320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EZH22_16335	COG0183	Belongs to the thiolase family
EZH22_16350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EZH22_16365	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EZH22_16370	COG4208	sulfate ABC transporter
EZH22_16375	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EZH22_16385	COG0175	sulfate reduction
EZH22_16395	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EZH22_16405	COG1024	Enoyl-CoA hydratase
EZH22_16425	COG1137	ATPase activity
EZH22_16430	COG0410	ABC transporter
EZH22_16435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EZH22_16440	COG0358	DNA primase activity
EZH22_16450	COG0505	Belongs to the CarA family
EZH22_16460	COG1802	Transcriptional regulator
EZH22_16470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_16490	COG0166	Belongs to the GPI family
EZH22_16495	COG0363	glucosamine-6-phosphate deaminase activity
EZH22_16500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EZH22_16505	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EZH22_16515	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EZH22_16550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EZH22_16555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EZH22_16560	COG1960	acyl-CoA dehydrogenase activity
EZH22_16565	COG2321	neutral zinc metallopeptidase
EZH22_16570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EZH22_16575	COG1294	oxidase, subunit
EZH22_16580	COG1271	oxidase subunit
EZH22_16585	COG0443	Heat shock 70 kDa protein
EZH22_16590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_16600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_16615	COG2132	Multicopper oxidase
EZH22_16630	COG2902	Dehydrogenase
EZH22_16680	COG1024	Enoyl-CoA hydratase
EZH22_16680	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_16685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZH22_16695	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_16715	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EZH22_16725	COG3135	benzoate transporter
EZH22_16735	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EZH22_16770	COG0248	Ppx GppA phosphatase
EZH22_16775	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EZH22_16785	COG0628	permease
EZH22_16795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EZH22_16805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EZH22_16810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EZH22_16820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EZH22_16825	COG1561	YicC-like family, N-terminal region
EZH22_16830	COG0194	GDP metabolic process
EZH22_16835	COG3161	chorismate lyase activity
EZH22_16870	COG4695	Portal protein
EZH22_16895	COG0741	lytic transglycosylase activity
EZH22_17030	COG2095	MarC family integral membrane protein
EZH22_17040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EZH22_17065	COG1960	acyl-CoA dehydrogenase activity
EZH22_17075	COG0346	lactoylglutathione lyase activity
EZH22_17085	COG0602	queuosine metabolic process
EZH22_17090	COG0720	synthase
EZH22_17095	COG0431	NADPH-dependent FMN reductase
EZH22_17115	COG2132	Multicopper oxidase
EZH22_17125	COG0672	)-iron permease
EZH22_17135	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EZH22_17140	COG4149	molybdate abc transporter
EZH22_17145	COG0725	ABC transporter, periplasmic molybdate-binding protein
EZH22_17150	COG0586	Pfam SNARE associated Golgi protein
EZH22_17155	COG0513	Belongs to the DEAD box helicase family
EZH22_17175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_17180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_17185	COG1278	Cold shock
EZH22_17190	COG1376	ErfK ybiS ycfS ynhG family protein
EZH22_17195	COG2267	carboxylic ester hydrolase activity
EZH22_17210	COG3685	Protein conserved in bacteria
EZH22_17235	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_17240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_17265	COG0546	phosphoglycolate phosphatase activity
EZH22_17275	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EZH22_17285	COG0438	transferase activity, transferring glycosyl groups
EZH22_17285	COG1216	Glycosyl transferase, family 2
EZH22_17295	COG2814	Major facilitator Superfamily
EZH22_17310	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EZH22_17325	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_17345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_17355	COG5265	(ABC) transporter
EZH22_17385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EZH22_17400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EZH22_17405	COG3383	formate dehydrogenase (NAD+) activity
EZH22_17420	COG0583	DNA-binding transcription factor activity
EZH22_17470	COG0387	Pfam Sodium calcium exchanger
EZH22_17475	COG0010	Belongs to the arginase family
EZH22_17480	COG3706	GGDEF domain
EZH22_17500	COG0745	RESPONSE REGULATOR receiver
EZH22_17510	COG0436	Aminotransferase
EZH22_17525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EZH22_17550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EZH22_17555	COG4770	biotin carboxylase activity
EZH22_17560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZH22_17565	COG3800	Transcriptional regulator
EZH22_17565	COG1396	sequence-specific DNA binding
EZH22_17590	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EZH22_17605	COG0215	cysteine-tRNA ligase activity
EZH22_17615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EZH22_17620	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EZH22_17635	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_17645	COG1309	transcriptional regulator
EZH22_17670	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EZH22_17680	COG2423	ornithine cyclodeaminase activity
EZH22_17690	COG0145	ligase activity
EZH22_17695	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
EZH22_17700	COG4647	ligase activity
EZH22_17705	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EZH22_17725	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EZH22_17735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EZH22_17740	COG0560	Phosphoserine phosphatase
EZH22_17760	COG0330	HflC and HflK could
EZH22_17765	COG0330	HflC and HflK could
EZH22_17780	COG0114	fumarate hydratase activity
EZH22_17790	COG1704	LemA family
EZH22_17795	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EZH22_17810	COG0039	L-malate dehydrogenase activity
EZH22_17820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EZH22_17825	COG0049	tRNA binding
EZH22_17830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EZH22_17835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EZH22_17840	COG0051	transcription antitermination factor activity, RNA binding
EZH22_17845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EZH22_17850	COG0088	Forms part of the polypeptide exit tunnel
EZH22_17855	COG0089	rRNA binding
EZH22_17860	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EZH22_17865	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EZH22_17870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EZH22_17875	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EZH22_17880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EZH22_17885	COG0255	Belongs to the universal ribosomal protein uL29 family
EZH22_17890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EZH22_17895	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EZH22_17900	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EZH22_17905	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EZH22_17910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EZH22_17915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EZH22_17920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EZH22_17925	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EZH22_17930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EZH22_17935	COG1841	ribosomal large subunit assembly
EZH22_17940	COG0200	Binds to the 23S rRNA
EZH22_17945	COG0201	protein transport
EZH22_17950	COG0563	adenylate kinase activity
EZH22_17955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EZH22_17960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EZH22_17965	COG0202	RNA polymerase activity
EZH22_17970	COG0203	ribosomal protein L17
EZH22_17975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZH22_17980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EZH22_17990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EZH22_18010	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EZH22_18020	COG0546	phosphoglycolate phosphatase activity
EZH22_18035	COG0513	Belongs to the DEAD box helicase family
EZH22_18050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EZH22_18055	COG2610	gluconate transmembrane transporter activity
EZH22_18060	COG1192	Involved in chromosome partitioning
EZH22_18085	COG1494	fructose-1,6-bisphosphatase
EZH22_18095	COG0436	Aminotransferase
EZH22_18105	COG3243	poly(R)-hydroxyalkanoic acid synthase
EZH22_18115	COG0612	Peptidase, M16
EZH22_18125	COG1393	Belongs to the ArsC family
EZH22_18190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_18195	COG1960	acyl-CoA dehydrogenase activity
EZH22_18200	COG0183	Belongs to the thiolase family
EZH22_18215	COG0688	phosphatidylethanolamine metabolic process
EZH22_18225	COG0747	negative chemotaxis
EZH22_18230	COG0601	transmembrane transport
EZH22_18235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZH22_18260	COG1802	Transcriptional regulator
EZH22_18270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EZH22_18285	COG0537	adenosine 5'-monophosphoramidase activity
EZH22_18290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EZH22_18305	COG2308	Evidence 4 Homologs of previously reported genes of
EZH22_18310	COG1058	Belongs to the CinA family
EZH22_18310	COG1546	Belongs to the CinA family
EZH22_18360	COG1088	dTDP-glucose 4,6-dehydratase activity
EZH22_18365	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EZH22_18370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EZH22_18375	COG2200	EAL domain
EZH22_18375	COG2199	diguanylate cyclase activity
EZH22_18375	COG2202	Pas domain
EZH22_18380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EZH22_18385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EZH22_18390	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EZH22_18395	COG2945	thiolester hydrolase activity
EZH22_18400	COG1104	cysteine desulfurase activity
EZH22_18405	COG0719	Fe-S assembly protein
EZH22_18410	COG0396	ATPase activity
EZH22_18420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EZH22_18425	COG2151	metal-sulfur cluster biosynthetic enzyme
EZH22_18445	COG0442	prolyl-tRNA aminoacylation
EZH22_18455	COG1136	(ABC) transporter
EZH22_18490	COG1396	sequence-specific DNA binding
EZH22_18505	COG0395	ABC-type sugar transport system, permease component
EZH22_18530	COG1960	acyl-CoA dehydrogenase activity
EZH22_18535	COG1024	Enoyl-CoA hydratase
EZH22_18535	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_18540	COG0183	Belongs to the thiolase family
EZH22_18550	COG2067	long-chain fatty acid transport protein
EZH22_18555	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_18560	COG0052	Belongs to the universal ribosomal protein uS2 family
EZH22_18565	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EZH22_18570	COG0528	UMP kinase activity
EZH22_18575	COG0233	cytoplasmic translational termination
EZH22_18580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EZH22_18590	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EZH22_18595	COG0750	zinc metalloprotease
EZH22_18600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZH22_18610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EZH22_18615	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EZH22_18620	COG3494	Protein of unknown function (DUF1009)
EZH22_18630	COG0372	Belongs to the citrate synthase family
EZH22_18635	COG0746	molybdenum cofactor guanylyltransferase activity
EZH22_18660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EZH22_18665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EZH22_18675	COG2832	Protein of unknown function (DUF454)
EZH22_18680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EZH22_18685	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EZH22_18700	COG1472	Belongs to the glycosyl hydrolase 3 family
EZH22_18705	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EZH22_18710	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EZH22_18715	COG3842	ATPase activity
EZH22_18720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EZH22_18725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EZH22_18730	COG0805	protein transport
EZH22_18735	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EZH22_18740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EZH22_18745	COG1862	Preprotein translocase
EZH22_18750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EZH22_18760	COG3737	Protein of unknown function (DUF498/DUF598)
EZH22_18775	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EZH22_18790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EZH22_18800	COG0629	single-stranded DNA binding
EZH22_18810	COG1280	lysine exporter protein (LysE YggA)
EZH22_18815	COG0514	ATP-dependent DNA helicase (RecQ)
EZH22_18820	COG3609	addiction module antidote protein, CC2985 family
EZH22_18830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EZH22_18835	COG0154	amidase activity
EZH22_18840	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EZH22_18860	COG2239	Acts as a magnesium transporter
EZH22_18870	COG5001	Diguanylate cyclase
EZH22_18880	COG2154	pterin-4-alpha-carbinolamine dehydratase
EZH22_18890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EZH22_18895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EZH22_18905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EZH22_18915	COG1509	lysine 2,3-aminomutase activity
EZH22_18925	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EZH22_18925	COG3608	succinylglutamate desuccinylase aspartoacylase
EZH22_18930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EZH22_18950	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EZH22_18960	COG0477	Major facilitator Superfamily
EZH22_18965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EZH22_18970	COG0758	DNA mediated transformation
EZH22_18975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EZH22_18980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EZH22_18985	COG0540	Belongs to the ATCase OTCase family
EZH22_19000	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EZH22_19010	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EZH22_19010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EZH22_19025	COG2204	response regulator
EZH22_19030	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EZH22_19070	COG1254	Belongs to the acylphosphatase family
EZH22_19080	COG0456	acetyltransferase
EZH22_19085	COG0625	glutathione transferase activity
EZH22_19120	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EZH22_19135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EZH22_19145	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EZH22_19150	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EZH22_19155	COG0047	phosphoribosylformylglycinamidine synthase activity
EZH22_19165	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EZH22_19180	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EZH22_19190	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EZH22_19200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EZH22_19210	COG0784	Response regulator, receiver
EZH22_19215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EZH22_19235	COG0557	exoribonuclease II activity
EZH22_19265	COG2301	Belongs to the HpcH HpaI aldolase family
EZH22_19275	COG0679	Auxin Efflux Carrier
EZH22_19280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_19285	COG0861	Integral membrane protein TerC family
EZH22_19290	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_19305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EZH22_19310	COG0736	holo-[acyl-carrier-protein] synthase activity
EZH22_19315	COG0681	Belongs to the peptidase S26 family
EZH22_19325	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EZH22_19340	COG1131	(ABC) transporter
EZH22_19370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EZH22_19385	COG0406	alpha-ribazole phosphatase activity
EZH22_19395	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EZH22_19410	COG0477	Major facilitator Superfamily
EZH22_19425	COG2239	Acts as a magnesium transporter
EZH22_19440	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_19460	COG0829	nickel cation binding
EZH22_19470	COG0832	Belongs to the urease beta subunit family
EZH22_19470	COG0831	urea catabolic process
EZH22_19480	COG0804	urea catabolic process
EZH22_19485	COG0783	Belongs to the Dps family
EZH22_19490	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EZH22_19495	COG0830	nickel cation binding
EZH22_19500	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EZH22_19520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EZH22_19530	COG0438	transferase activity, transferring glycosyl groups
EZH22_19540	COG0156	8-amino-7-oxononanoate synthase activity
EZH22_19545	COG3321	synthase
EZH22_19545	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_19545	COG0604	alcohol dehydrogenase
EZH22_19565	COG0110	maltose O-acetyltransferase activity
EZH22_19585	COG0438	transferase activity, transferring glycosyl groups
EZH22_19590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EZH22_19595	COG0438	transferase activity, transferring glycosyl groups
EZH22_19650	COG1696	Membrane protein involved in D-alanine export
EZH22_19665	COG0316	Belongs to the HesB IscA family
EZH22_19670	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EZH22_19675	COG0018	arginyl-trna synthetase
EZH22_19695	COG0730	response to heat
EZH22_19700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EZH22_19705	COG1902	pentaerythritol trinitrate reductase activity
EZH22_19715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZH22_19720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_19735	COG4948	Mandelate Racemase Muconate Lactonizing
EZH22_19750	COG3842	ATPase activity
EZH22_19755	COG1176	ABC-type spermidine putrescine transport system, permease component I
EZH22_19760	COG1177	transmembrane transport
EZH22_19800	COG0671	phosphoesterase, PA-phosphatase related
EZH22_19805	COG0463	Glycosyl transferase, family 2
EZH22_19815	COG0626	cystathionine gamma-synthase activity
EZH22_19820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_19825	COG4597	amino acid ABC transporter
EZH22_19830	COG0765	amino acid transport
EZH22_19835	COG1126	abc transporter atp-binding protein
EZH22_19845	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EZH22_19860	COG1686	Belongs to the peptidase S11 family
EZH22_19870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EZH22_19905	COG0174	glutamine synthetase
EZH22_19910	COG0347	Belongs to the P(II) protein family
EZH22_19935	COG0628	permease
EZH22_19940	COG1309	transcriptional regulator
EZH22_19945	COG3246	L-lysine catabolic process to acetate
EZH22_19980	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_19995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EZH22_20000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_20005	COG0673	inositol 2-dehydrogenase activity
EZH22_20025	COG2084	Dehydrogenase
EZH22_20035	COG1802	Transcriptional regulator
EZH22_20075	COG2010	Cytochrome c
EZH22_20075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZH22_20080	COG2080	2 iron, 2 sulfur cluster binding
EZH22_20085	COG2084	Dehydrogenase
EZH22_20100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EZH22_20105	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_20110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_20115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_20130	COG1802	Transcriptional regulator
EZH22_20140	COG0523	cobalamin synthesis protein
EZH22_20150	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EZH22_20155	COG0148	phosphopyruvate hydratase activity
EZH22_20160	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_20165	COG2095	MarC family integral membrane protein
EZH22_20170	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EZH22_20180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EZH22_20185	COG0113	porphobilinogen synthase activity
EZH22_20190	COG1024	Enoyl-CoA hydratase
EZH22_20200	COG4122	O-methyltransferase activity
EZH22_20210	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_20220	COG0134	indole-3-glycerol-phosphate synthase activity
EZH22_20245	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EZH22_20250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EZH22_20260	COG0459	protein refolding
EZH22_20265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EZH22_20270	COG5425	PFAM Usg family protein
EZH22_20275	COG0693	protein deglycase activity
EZH22_20290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EZH22_20295	COG0343	queuine tRNA-ribosyltransferase activity
EZH22_20300	COG1960	acyl-CoA dehydrogenase activity
EZH22_20320	COG0848	biopolymer transport protein
EZH22_20330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EZH22_20335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EZH22_20340	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZH22_20340	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZH22_20350	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EZH22_20355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EZH22_20360	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EZH22_20375	COG0544	peptidyl-prolyl cis-trans isomerase activity
EZH22_20380	COG0740	serine-type endopeptidase activity
EZH22_20385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EZH22_20390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EZH22_20395	COG0776	regulation of translation
EZH22_20415	COG0400	carboxylic ester hydrolase activity
EZH22_20420	COG0346	lactoylglutathione lyase activity
EZH22_20445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_20450	COG1116	anion transmembrane transporter activity
EZH22_20455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_20465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZH22_20485	COG1840	ABC-type Fe3 transport system, periplasmic component
EZH22_20545	COG1492	cobalamin metabolic process
EZH22_20575	COG3768	UPF0283 membrane protein
EZH22_20580	COG3106	COG3106 Predicted ATPase
EZH22_20600	COG3191	aminopeptidase activity
EZH22_20605	COG0785	Cytochrome C biogenesis protein
EZH22_20625	COG0416	fatty acid biosynthetic process
EZH22_20630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EZH22_20635	COG0776	regulation of translation
EZH22_20640	COG3956	TIGRFAM MazG family protein
EZH22_20655	COG0321	lipoyl(octanoyl) transferase activity
EZH22_20655	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EZH22_20675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EZH22_20685	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EZH22_20690	COG1923	regulation of RNA biosynthetic process
EZH22_20695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EZH22_20705	COG0569	domain protein
EZH22_20710	COG2204	response regulator
EZH22_20715	COG5000	phosphorelay sensor kinase activity
EZH22_20720	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EZH22_20740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EZH22_20755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EZH22_20760	COG0134	indole-3-glycerol-phosphate synthase activity
EZH22_20770	COG0315	cyclic pyranopterin monophosphate synthase activity
EZH22_20775	COG0303	'Molybdopterin
EZH22_20780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EZH22_20795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EZH22_20805	COG1473	amidohydrolase
EZH22_20815	COG0457	Tetratricopeptide repeat
EZH22_20835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EZH22_20860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_20880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EZH22_20900	COG0628	permease
EZH22_20920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EZH22_20925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EZH22_20940	COG1024	Enoyl-CoA hydratase
EZH22_20955	COG1612	heme a metabolic process
EZH22_20960	COG1346	cytolysis
EZH22_20965	COG1380	Effector of murein hydrolase LrgA
EZH22_20970	COG0583	DNA-binding transcription factor activity
EZH22_20980	COG1832	CoA-binding protein
EZH22_20985	COG0084	hydrolase, TatD family'
EZH22_21010	COG0470	DNA polymerase III
EZH22_21015	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EZH22_21020	COG1686	Belongs to the peptidase S11 family
EZH22_21045	COG0655	NAD(P)H dehydrogenase (quinone) activity
EZH22_21080	COG4221	oxidoreductase activity
EZH22_21095	COG4221	oxidoreductase activity
EZH22_21135	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
EZH22_21150	COG5383	Protein conserved in bacteria
EZH22_21160	COG2264	protein methyltransferase activity
EZH22_21165	COG0583	DNA-binding transcription factor activity
EZH22_21180	COG0543	2 iron, 2 sulfur cluster binding
EZH22_21180	COG0633	Ferredoxin
EZH22_21185	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EZH22_21230	COG3852	Histidine kinase
EZH22_21260	COG1309	transcriptional regulator
EZH22_21265	COG4608	Belongs to the ABC transporter superfamily
EZH22_21270	COG0444	Belongs to the ABC transporter superfamily
EZH22_21280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZH22_21285	COG0747	negative chemotaxis
EZH22_21310	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EZH22_21325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZH22_21350	COG3263	regulation of cellular component size
EZH22_21365	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EZH22_21370	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EZH22_21395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EZH22_21400	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EZH22_21405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZH22_21410	COG4558	Periplasmic binding protein
EZH22_21415	COG4771	TonB-dependent receptor
EZH22_21420	COG2329	Antibiotic biosynthesis monooxygenase
EZH22_21440	COG3795	YCII-related domain
EZH22_21445	COG4941	Belongs to the sigma-70 factor family
EZH22_21455	COG5265	(ABC) transporter
EZH22_21525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EZH22_21590	COG3617	BRO family, N-terminal domain
EZH22_21595	COG4974	Belongs to the 'phage' integrase family
EZH22_21610	COG1002	Type II restriction enzyme, methylase subunits
EZH22_21695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_21715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZH22_21735	COG2186	Transcriptional regulator
EZH22_21755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZH22_21765	COG1960	acyl-CoA dehydrogenase activity
EZH22_21790	COG1126	abc transporter atp-binding protein
EZH22_21795	COG0765	amino acid transport
EZH22_21830	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_21860	COG0633	Ferredoxin
EZH22_21865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_21880	COG1309	transcriptional regulator
EZH22_21895	COG0183	Belongs to the thiolase family
EZH22_21905	COG1024	Enoyl-CoA hydratase
EZH22_21955	COG0683	leucine binding
EZH22_21960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EZH22_21965	COG2867	negative regulation of translational initiation
EZH22_21970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EZH22_21980	COG2261	transglycosylase associated protein
EZH22_21985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZH22_22000	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZH22_22005	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZH22_22005	COG0022	dehydrogenase e1 component
EZH22_22015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EZH22_22025	COG1381	Involved in DNA repair and RecF pathway recombination
EZH22_22040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EZH22_22095	COG3246	L-lysine catabolic process to acetate
EZH22_22160	COG1414	Transcriptional regulator
EZH22_22165	COG1744	ABC transporter substrate-binding protein PnrA-like
EZH22_22170	COG3845	ABC transporter
EZH22_22175	COG3845	ABC transporter
EZH22_22185	COG1079	Belongs to the binding-protein-dependent transport system permease family
EZH22_22190	COG4607	ABC-type enterochelin transport system periplasmic component
EZH22_22200	COG4605	iron ion homeostasis
EZH22_22205	COG4604	ABC transporter, ATP-binding protein
EZH22_22215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZH22_22220	COG1136	(ABC) transporter
EZH22_22220	COG0577	efflux transmembrane transporter activity
EZH22_22225	COG3433	isochorismatase activity
EZH22_22225	COG1535	isochorismatase
EZH22_22235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EZH22_22240	COG1169	isochorismate synthase
EZH22_22245	COG1021	2,3-dihydroxybenzoate-AMP ligase
EZH22_22250	COG1535	isochorismatase
EZH22_22250	COG3433	isochorismatase activity
EZH22_22255	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_22265	COG4774	siderophore transport
EZH22_22280	COG0243	molybdopterin cofactor binding
EZH22_22285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZH22_22305	COG1129	ABC transporter
EZH22_22310	COG1137	ATPase activity
EZH22_22315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZH22_22370	COG3220	belongs to the UPF0276 family
EZH22_22410	COG2948	multi-organism process
EZH22_22425	COG3846	protein secretion by the type IV secretion system
EZH22_22440	COG3451	type IV secretory pathway VirB4
EZH22_22455	COG4962	Type ii secretion system protein e
EZH22_22475	COG0741	lytic transglycosylase activity
EZH22_22500	COG1192	Involved in chromosome partitioning
EZH22_22535	COG5489	Protein of unknown function (DUF736)
EZH22_22585	COG4227	nucleotidyltransferase activity
EZH22_22610	COG0420	3'-5' exonuclease activity
EZH22_22620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EZH22_22635	COG0556	nucleotide-excision repair
EZH22_22675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EZH22_22710	COG1132	(ABC) transporter
EZH22_22720	COG2346	COG2346, Truncated hemoglobins
EZH22_22725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EZH22_22740	COG0525	valine-tRNA ligase activity
EZH22_22760	COG2076	Multidrug Resistance protein
EZH22_22770	COG0504	CTP synthase activity
EZH22_22780	COG2252	PERMEase
EZH22_22785	COG0739	heme binding
EZH22_22795	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EZH22_22800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EZH22_22805	COG1758	RNA polymerase activity
EZH22_22815	COG1573	uracil-dna glycosylase
EZH22_22830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EZH22_22840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZH22_22845	COG0741	lytic transglycosylase activity
EZH22_22850	COG0633	Ferredoxin
EZH22_22875	COG1127	ABC transporter
EZH22_22880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EZH22_22885	COG4948	Mandelate Racemase Muconate Lactonizing
EZH22_22900	COG0438	transferase activity, transferring glycosyl groups
EZH22_22915	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_22920	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EZH22_22960	COG1530	ribonuclease E activity
EZH22_22960	COG1530	ribonuclease E activity
EZH22_22965	COG0860	N-Acetylmuramoyl-L-alanine amidase
EZH22_22970	COG1335	isochorismatase
EZH22_22980	COG2079	MmgE PrpD family protein
EZH22_23005	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
EZH22_23010	COG2301	Belongs to the HpcH HpaI aldolase family
EZH22_23015	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_23020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_23030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_23060	COG0538	isocitrate dehydrogenase activity
EZH22_23065	COG0297	glycogen (starch) synthase activity
EZH22_23070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZH22_23085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EZH22_23090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EZH22_23115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EZH22_23120	COG0477	Major facilitator Superfamily
EZH22_23125	COG0415	Belongs to the DNA photolyase family
EZH22_23130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EZH22_23135	COG2897	thiosulfate sulfurtransferase activity
EZH22_23140	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EZH22_23140	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EZH22_23225	COG0110	maltose O-acetyltransferase activity
EZH22_23250	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EZH22_23270	COG0489	protein tyrosine kinase activity
EZH22_23270	COG3206	protein involved in exopolysaccharide biosynthesis
EZH22_23295	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EZH22_23310	COG0356	it plays a direct role in the translocation of protons across the membrane
EZH22_23370	COG4948	Mandelate Racemase Muconate Lactonizing
EZH22_23375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZH22_23380	COG0179	Fumarylacetoacetate (FAA) hydrolase
EZH22_23385	COG4948	Mandelate Racemase Muconate Lactonizing
EZH22_23390	COG3181	Tripartite tricarboxylate transporter family receptor
EZH22_23395	COG1802	Transcriptional regulator
EZH22_23410	COG1132	(ABC) transporter
EZH22_23430	COG1566	PFAM secretion protein HlyD family protein
EZH22_23450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_23455	COG0154	amidase activity
EZH22_23485	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EZH22_23490	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EZH22_23505	COG3634	alkyl hydroperoxide reductase activity
EZH22_23525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_23530	COG4303	Ethanolamine ammonia lyase large subunit
EZH22_23535	COG4302	ethanolamine ammonia-lyase activity
EZH22_23585	COG0438	transferase activity, transferring glycosyl groups
EZH22_23600	COG3436	PFAM IS66 Orf2 family protein
EZH22_23625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EZH22_23635	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EZH22_23650	COG0438	transferase activity, transferring glycosyl groups
EZH22_23660	COG4372	Transposase
EZH22_23665	COG3436	PFAM IS66 Orf2 family protein
EZH22_23670	COG2963	transposase activity
EZH22_23695	COG2963	transposase activity
EZH22_23700	COG3436	PFAM IS66 Orf2 family protein
EZH22_23725	COG0316	Belongs to the HesB IscA family
EZH22_23730	COG5001	Diguanylate cyclase
EZH22_23730	COG3300	MHYT domain
EZH22_23740	COG0346	lactoylglutathione lyase activity
EZH22_23755	COG1007	ATP synthesis coupled electron transport
EZH22_23770	COG0713	ATP synthesis coupled electron transport
EZH22_23780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZH22_23785	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EZH22_23800	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EZH22_23810	COG0649	NAD binding
EZH22_23815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZH22_23820	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZH22_23830	COG3064	Membrane
EZH22_23850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EZH22_23880	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EZH22_23890	COG0109	protoheme IX farnesyltransferase activity
EZH22_23895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EZH22_23900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EZH22_23910	COG0475	glutathione-regulated potassium exporter activity
EZH22_23910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EZH22_23925	COG0583	DNA-binding transcription factor activity
EZH22_23930	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EZH22_23955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_24040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EZH22_24050	COG1278	Cold shock
EZH22_24100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EZH22_24150	COG0656	L-ascorbic acid biosynthetic process
EZH22_24155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EZH22_24160	COG0583	DNA-binding transcription factor activity
EZH22_24165	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_24195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_24200	COG1116	anion transmembrane transporter activity
EZH22_24255	COG0714	Associated with various cellular activities
EZH22_24270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_24275	COG4993	Dehydrogenase
EZH22_24510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EZH22_24685	COG0675	Transposase, IS605 OrfB family
EZH22_24750	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EZH22_24760	COG0069	glutamate synthase activity
EZH22_24780	COG0583	DNA-binding transcription factor activity
EZH22_24785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZH22_24795	COG0446	pyridine nucleotide-disulphide oxidoreductase
EZH22_24795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EZH22_24830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EZH22_24835	COG0803	Belongs to the bacterial solute-binding protein 9 family
EZH22_24840	COG0523	cobalamin synthesis protein
EZH22_24845	COG0800	Aldolase
EZH22_24860	COG0511	ligase activity, forming carbon-carbon bonds
EZH22_24865	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EZH22_24900	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EZH22_24930	COG0583	DNA-binding transcription factor activity
EZH22_24940	COG2205	protein histidine kinase activity
EZH22_24940	COG2202	Pas domain
EZH22_24955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EZH22_24965	COG0745	RESPONSE REGULATOR receiver
EZH22_24970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZH22_24975	COG3088	subunit of a heme lyase
EZH22_24980	COG1138	Cytochrome C-type biogenesis protein
EZH22_24985	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EZH22_24990	COG4235	cytochrome complex assembly
EZH22_25020	COG0411	ABC transporter
EZH22_25040	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZH22_25045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EZH22_25075	COG2358	TRAP transporter, solute receptor (TAXI family
EZH22_25080	COG2080	2 iron, 2 sulfur cluster binding
EZH22_25085	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EZH22_25090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EZH22_25105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZH22_25110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZH22_25115	COG1120	ATPase activity
EZH22_25120	COG4774	siderophore transport
EZH22_25155	COG1132	(ABC) transporter
EZH22_25170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EZH22_25175	COG1120	ATPase activity
EZH22_25180	COG4774	siderophore transport
EZH22_25235	COG4608	Belongs to the ABC transporter superfamily
EZH22_25245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZH22_25250	COG0601	transmembrane transport
EZH22_25255	COG0747	negative chemotaxis
EZH22_25270	COG2271	Major facilitator Superfamily
EZH22_25275	COG0066	3-isopropylmalate dehydratase activity
EZH22_25280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EZH22_25285	COG4948	Mandelate Racemase Muconate Lactonizing
EZH22_25290	COG0583	DNA-binding transcription factor activity
EZH22_25365	COG1137	ATPase activity
EZH22_25390	COG0243	molybdopterin cofactor binding
EZH22_25405	COG0582	viral genome integration into host DNA
EZH22_25425	COG0433	COG0433 Predicted ATPase
EZH22_25450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EZH22_25465	COG0726	polysaccharide deacetylase
EZH22_25470	COG0235	Class ii aldolase
EZH22_25475	COG2084	Dehydrogenase
EZH22_25490	COG1522	sequence-specific DNA binding
EZH22_25495	COG2066	Belongs to the glutaminase family
EZH22_25495	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EZH22_25535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_25555	COG1414	Transcriptional regulator
EZH22_25565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZH22_25570	COG0583	DNA-binding transcription factor activity
EZH22_25575	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EZH22_25580	COG1228	amidohydrolase
EZH22_25600	COG4603	Belongs to the binding-protein-dependent transport system permease family
EZH22_25620	COG2223	nitrite transmembrane transporter activity
EZH22_25630	COG1140	nitrate reductase beta subunit
EZH22_25635	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EZH22_25640	COG2181	nitrate reductase activity
EZH22_25645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EZH22_25655	COG0288	reversible hydration of carbon dioxide
EZH22_25685	COG1082	Xylose isomerase domain protein TIM barrel
EZH22_25685	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EZH22_25695	COG3962	Belongs to the TPP enzyme family
EZH22_25700	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EZH22_25705	COG0045	succinate-CoA ligase (ADP-forming) activity
EZH22_25710	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_25715	COG1960	acyl-CoA dehydrogenase activity
EZH22_25720	COG0583	DNA-binding transcription factor activity
EZH22_25745	COG0395	ABC-type sugar transport system, permease component
EZH22_25750	COG1175	transmembrane transport
EZH22_25760	COG3842	ATPase activity
EZH22_25770	COG0277	FAD linked oxidase domain protein
EZH22_25790	COG2032	superoxide dismutase activity
EZH22_25795	COG1609	Transcriptional regulator
EZH22_25800	COG0300	oxidoreductase activity
EZH22_25805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_25830	COG1175	transmembrane transport
EZH22_25845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EZH22_25875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_25885	COG0583	DNA-binding transcription factor activity
EZH22_25890	COG0154	amidase activity
EZH22_25895	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EZH22_25920	COG0583	DNA-binding transcription factor activity
EZH22_25925	COG0402	S-adenosylhomocysteine deaminase activity
EZH22_25930	COG0154	amidase activity
EZH22_25940	COG1733	regulation of RNA biosynthetic process
EZH22_25945	COG1335	isochorismatase
EZH22_25960	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EZH22_25975	COG3300	MHYT domain
EZH22_25975	COG5001	Diguanylate cyclase
EZH22_25995	COG2205	protein histidine kinase activity
EZH22_26005	COG0281	malic enzyme
EZH22_26005	COG0280	phosphate acetyltransferase
EZH22_26030	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EZH22_26035	COG2166	iron-sulfur cluster assembly
EZH22_26060	COG5328	Belongs to the UPF0262 family
EZH22_26070	COG5001	Diguanylate cyclase
EZH22_26070	COG3300	MHYT domain
EZH22_26085	COG0628	permease
EZH22_26105	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EZH22_26110	COG3665	Urea carboxylase-associated protein
EZH22_26115	COG3665	Urea carboxylase-associated protein
EZH22_26185	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
EZH22_26190	COG1797	cobyrinic acid a,c-diamide synthase activity
EZH22_26210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZH22_26215	COG0842	Transport permease protein
EZH22_26220	COG1131	(ABC) transporter
EZH22_26240	COG1960	acyl-CoA dehydrogenase activity
EZH22_26245	COG0009	L-threonylcarbamoyladenylate synthase
EZH22_26250	COG0456	acetyltransferase
EZH22_26255	COG0123	including yeast histone deacetylase and acetoin utilization protein
EZH22_26280	COG0574	Belongs to the PEP-utilizing enzyme family
EZH22_26280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EZH22_26290	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
EZH22_26305	COG2351	hydroxyisourate hydrolase activity
EZH22_26330	COG3181	Tripartite tricarboxylate transporter family receptor
EZH22_26335	COG0583	DNA-binding transcription factor activity
EZH22_26350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZH22_26355	COG0628	permease
EZH22_26375	COG0210	DNA helicase
EZH22_26395	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EZH22_26410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EZH22_26410	COG1793	dna ligase
EZH22_26420	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EZH22_26420	COG1793	dna ligase
EZH22_26440	COG0534	Mate efflux family protein
EZH22_26460	COG0228	four-way junction DNA binding
EZH22_26465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EZH22_26500	COG0657	acetylesterase activity
EZH22_26505	COG0432	Pfam Uncharacterised protein family UPF0047
EZH22_26515	COG2223	nitrite transmembrane transporter activity
EZH22_26530	COG0495	leucyl-tRNA aminoacylation
EZH22_26540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EZH22_26545	COG0359	binds to the 23S rRNA
EZH22_26555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EZH22_26560	COG0360	Binds together with S18 to 16S ribosomal RNA
EZH22_26565	COG0726	polysaccharide deacetylase
EZH22_26570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EZH22_26585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EZH22_26590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EZH22_26600	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
EZH22_26615	COG0824	Thioesterase
EZH22_26640	COG0587	DNA-directed DNA polymerase activity
EZH22_26660	COG1489	DNA binding
EZH22_26675	COG0596	Alpha beta hydrolase
EZH22_26690	COG0590	tRNA wobble adenosine to inosine editing
EZH22_26695	COG1187	pseudouridine synthase activity
EZH22_26700	COG0742	ribosomal rna small subunit methyltransferase
EZH22_26705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EZH22_26710	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EZH22_26715	COG0459	protein refolding
EZH22_26730	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EZH22_26730	COG2066	Belongs to the glutaminase family
EZH22_26760	COG0181	hydroxymethylbilane synthase activity
EZH22_26765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EZH22_26770	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EZH22_26790	COG2264	protein methyltransferase activity
EZH22_26805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_26810	COG3706	GGDEF domain
EZH22_26815	COG2264	protein methyltransferase activity
EZH22_26830	COG0277	FAD linked oxidase domain protein
EZH22_26865	COG4974	Belongs to the 'phage' integrase family
EZH22_26875	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EZH22_26880	COG1595	DNA-templated transcription, initiation
EZH22_26895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EZH22_26910	COG3707	response regulator
EZH22_26915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_26920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EZH22_26925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_26930	COG1116	anion transmembrane transporter activity
EZH22_26940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EZH22_26950	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EZH22_26955	COG0243	molybdopterin cofactor binding
EZH22_26960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EZH22_26965	COG0456	acetyltransferase
EZH22_26975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZH22_26995	COG0438	transferase activity, transferring glycosyl groups
EZH22_27005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZH22_27010	COG0025	NhaP-type Na H and K H
EZH22_27015	COG4566	intracellular signal transduction
EZH22_27020	COG0783	Belongs to the Dps family
EZH22_27030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EZH22_27030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EZH22_27055	COG0243	molybdopterin cofactor binding
EZH22_27060	COG1271	oxidase subunit
EZH22_27075	COG4191	Histidine kinase
EZH22_27085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EZH22_27090	COG0251	oxidation-reduction process
EZH22_27115	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_27135	COG2188	Transcriptional regulator
EZH22_27160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_27165	COG1116	anion transmembrane transporter activity
EZH22_27170	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EZH22_27175	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_27185	COG1335	isochorismatase
EZH22_27210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EZH22_27225	COG0163	prenyltransferase activity
EZH22_27235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EZH22_27245	COG1040	competence protein
EZH22_27255	COG1937	Protein conserved in bacteria
EZH22_27260	COG0180	Tryptophanyl-tRNA synthetase
EZH22_27265	COG0728	peptidoglycan biosynthetic process
EZH22_27270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EZH22_27285	COG0302	gtp cyclohydrolase
EZH22_27290	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EZH22_27295	COG1752	Esterase of the alpha-beta hydrolase superfamily
EZH22_27300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZH22_27315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EZH22_27320	COG1324	tolerance protein
EZH22_27330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZH22_27335	COG1376	ErfK ybiS ycfS ynhG family protein
EZH22_27340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EZH22_27345	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EZH22_27360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EZH22_27365	COG0305	Participates in initiation and elongation during chromosome replication
EZH22_27395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZH22_27405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EZH22_27415	COG2005	Transcriptional regulator
EZH22_27420	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EZH22_27425	COG4133	protoheme IX ABC transporter activity
EZH22_27430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EZH22_27445	COG0640	Transcriptional regulator
EZH22_27475	COG0604	alcohol dehydrogenase
EZH22_27480	COG2186	Transcriptional regulator
EZH22_27495	COG1024	Enoyl-CoA hydratase
EZH22_27500	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_27505	COG3706	GGDEF domain
EZH22_27515	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EZH22_27525	COG1007	ATP synthesis coupled electron transport
EZH22_27560	COG0583	DNA-binding transcription factor activity
EZH22_27575	COG0402	S-adenosylhomocysteine deaminase activity
EZH22_27585	COG3485	protocatechuate 3,4-dioxygenase
EZH22_27590	COG0277	FAD linked oxidase domain protein
EZH22_27595	COG1129	ABC transporter
EZH22_27600	COG1172	Belongs to the binding-protein-dependent transport system permease family
EZH22_27605	COG1172	Belongs to the binding-protein-dependent transport system permease family
EZH22_27660	COG0714	Associated with various cellular activities
EZH22_27680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZH22_27685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_27690	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_27695	COG1902	pentaerythritol trinitrate reductase activity
EZH22_27700	COG1764	response to oxidative stress
EZH22_27710	COG1522	sequence-specific DNA binding
EZH22_27735	COG2205	protein histidine kinase activity
EZH22_27745	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EZH22_27760	COG2132	Multicopper oxidase
EZH22_27775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZH22_27785	COG2963	transposase activity
EZH22_27790	COG3436	PFAM IS66 Orf2 family protein
EZH22_27810	COG1396	sequence-specific DNA binding
EZH22_27815	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
EZH22_27820	COG2963	transposase activity
EZH22_27825	COG3436	PFAM IS66 Orf2 family protein
EZH22_27830	COG4372	Transposase
EZH22_27845	COG3436	PFAM IS66 Orf2 family protein
EZH22_27850	COG2963	transposase activity
EZH22_27885	COG2084	Dehydrogenase
EZH22_27900	COG0583	DNA-binding transcription factor activity
EZH22_27910	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZH22_27910	COG1024	Enoyl-CoA hydratase
EZH22_27915	COG1053	succinate dehydrogenase
EZH22_27920	COG0183	Belongs to the thiolase family
EZH22_27955	COG2814	Major facilitator Superfamily
EZH22_27960	COG1566	PFAM secretion protein HlyD family protein
EZH22_27970	COG1289	transmembrane transporter activity
EZH22_28000	COG5433	transposase activity
EZH22_28005	COG5433	transposase activity
EZH22_28010	COG1414	Transcriptional regulator
EZH22_28015	COG1024	Enoyl-CoA hydratase
EZH22_28020	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZH22_28020	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZH22_28165	COG4974	Belongs to the 'phage' integrase family
EZH22_28170	COG0582	viral genome integration into host DNA
EZH22_28175	COG4974	Belongs to the 'phage' integrase family
EZH22_28235	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
EZH22_28270	COG0640	Transcriptional regulator
EZH22_28290	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
EZH22_28300	COG1414	Transcriptional regulator
EZH22_28305	COG1475	DNA binding
EZH22_28310	COG1192	Involved in chromosome partitioning
EZH22_28335	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EZH22_28350	COG3838	Conjugal transfer protein Trbc
EZH22_28355	COG3702	type iv secretory pathway
EZH22_28360	COG3451	type IV secretory pathway VirB4
EZH22_28375	COG3704	protein secretion by the type IV secretion system
EZH22_28380	COG3736	Type IV secretory pathway, component VirB8
EZH22_28385	COG3504	Conjugal transfer protein
EZH22_28390	COG2948	multi-organism process
EZH22_28395	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
EZH22_28410	COG1484	DNA-dependent DNA replication
EZH22_28415	COG3335	DDE superfamily endonuclease
EZH22_28420	COG3415	Transposase
EZH22_28445	COG1024	Enoyl-CoA hydratase
EZH22_28450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZH22_28455	COG1309	transcriptional regulator
EZH22_28480	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_28485	COG1960	acyl-CoA dehydrogenase activity
EZH22_28495	COG1960	acyl-CoA dehydrogenase activity
EZH22_28500	COG2030	dehydratase
EZH22_28510	COG0183	Belongs to the thiolase family
EZH22_28550	COG1024	Enoyl-CoA hydratase
EZH22_28565	COG2963	transposase activity
EZH22_28570	COG3436	PFAM IS66 Orf2 family protein
EZH22_28575	COG4372	Transposase
EZH22_28580	COG1309	transcriptional regulator
EZH22_28585	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_28590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZH22_28620	COG1960	acyl-CoA dehydrogenase activity
EZH22_28635	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EZH22_28640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZH22_28670	COG3436	PFAM IS66 Orf2 family protein
EZH22_28680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZH22_28685	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EZH22_28705	COG1022	Amp-dependent synthetase and ligase
EZH22_28715	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_28765	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EZH22_28770	COG2086	electron transfer activity
EZH22_28780	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
EZH22_28810	COG3415	Transposase
EZH22_28815	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_28825	COG1960	acyl-CoA dehydrogenase activity
EZH22_28830	COG1960	acyl-CoA dehydrogenase activity
EZH22_28835	COG2030	dehydratase
EZH22_28845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_28850	COG2086	electron transfer activity
EZH22_28855	COG1024	Enoyl-CoA hydratase
EZH22_28860	COG1024	Enoyl-CoA hydratase
EZH22_28885	COG0559	Belongs to the binding-protein-dependent transport system permease family
EZH22_28890	COG1022	Amp-dependent synthetase and ligase
EZH22_28925	COG2030	dehydratase
EZH22_28940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EZH22_28940	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EZH22_28950	COG1960	acyl-CoA dehydrogenase activity
EZH22_28955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_28960	COG2188	Transcriptional regulator
EZH22_28970	COG2301	Belongs to the HpcH HpaI aldolase family
EZH22_28975	COG2226	methyltransferase
EZH22_28990	COG0604	alcohol dehydrogenase
EZH22_28990	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_28990	COG3321	synthase
EZH22_28995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_29005	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_29015	COG1028	Short-chain dehydrogenase reductase Sdr
EZH22_29020	COG2030	dehydratase
EZH22_29045	COG1414	Transcriptional regulator
EZH22_29055	COG1137	ATPase activity
EZH22_29085	COG3505	Type IV secretory pathway VirD4
EZH22_29090	COG3077	Addiction module antitoxin, RelB DinJ family
EZH22_29125	COG3831	ATPase activity
EZH22_29135	COG2161	toxin-antitoxin pair type II binding
EZH22_29150	COG5489	Protein of unknown function (DUF736)
EZH22_29165	COG4227	nucleotidyltransferase activity
EZH22_29205	COG1475	DNA binding
EZH22_29235	COG5642	Protein of unknown function (DUF2384)
EZH22_29250	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EZH22_29280	COG4974	Belongs to the 'phage' integrase family
EZH22_29310	COG2963	transposase activity
EZH22_29315	COG3436	PFAM IS66 Orf2 family protein
EZH22_29320	COG4372	Transposase
EZH22_29335	COG2205	protein histidine kinase activity
EZH22_29340	COG2814	Major facilitator Superfamily
EZH22_29360	COG2132	Multicopper oxidase
EZH22_29400	COG3831	ATPase activity
EZH22_29410	COG5489	Protein of unknown function (DUF736)
EZH22_29530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZH22_29535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZH22_29545	COG2132	Multicopper oxidase
EZH22_29600	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EZH22_29610	COG0247	lactate metabolic process
EZH22_29615	COG0277	FAD linked oxidase domain protein
EZH22_29620	COG0277	FAD linked oxidase domain protein
EZH22_29625	COG0625	glutathione transferase activity
EZH22_29630	COG0277	FAD linked oxidase domain protein
EZH22_29635	COG1012	belongs to the aldehyde dehydrogenase family
EZH22_29640	COG0318	PFAM AMP-dependent synthetase and ligase
EZH22_29660	COG0395	ABC-type sugar transport system, permease component
EZH22_29665	COG1175	transmembrane transport
EZH22_29675	COG3842	ATPase activity
EZH22_29680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EZH22_29720	COG4644	lycopene metabolic process
EZH22_29760	COG1063	alcohol dehydrogenase
EZH22_29785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EZH22_29835	COG4644	lycopene metabolic process
EZH22_29865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EZH22_29945	COG0640	Transcriptional regulator
EZH22_29950	COG1475	DNA binding
EZH22_29955	COG1192	Involved in chromosome partitioning
EZH22_29960	COG3916	Acyl-homoserine-lactone synthase
EZH22_29965	COG4962	Type ii secretion system protein e
EZH22_29970	COG3838	Conjugal transfer protein Trbc
EZH22_29980	COG3451	type IV secretory pathway VirB4
EZH22_29985	COG5314	conjugation
EZH22_29995	COG3846	protein secretion by the type IV secretion system
EZH22_30000	COG3701	Conjugal transfer protein
EZH22_30030	COG2815	serine threonine protein kinase
EZH22_30030	COG0515	serine threonine protein kinase
EZH22_30035	COG0515	serine threonine protein kinase
EZH22_30035	COG2815	serine threonine protein kinase
EZH22_30070	COG4959	Type IV secretory pathway protease TraF
EZH22_30160	COG1396	sequence-specific DNA binding
EZH22_30200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EZH22_30240	COG0789	Transcriptional regulator
EZH22_30245	COG2217	Heavy metal translocating P-type atpase
EZH22_30245	COG2217	Heavy metal translocating P-type atpase
EZH22_30360	COG0582	viral genome integration into host DNA
EZH22_30365	COG2827	Endonuclease containing a URI domain
EZH22_30460	COG4957	zinc ion binding
EZH22_30470	COG4957	zinc ion binding
EZH22_30490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EZH22_30505	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EZH22_30570	COG0210	DNA helicase
EZH22_30805	COG4957	zinc ion binding
EZH22_30830	COG4644	lycopene metabolic process
EZH22_30870	COG3047	cAMP biosynthetic process
EZH22_30880	COG1063	alcohol dehydrogenase
EZH22_30895	COG2871	sodium ion transport
EZH22_30940	COG0196	riboflavin kinase activity
EZH22_30960	COG0583	DNA-binding transcription factor activity
EZH22_30970	COG2135	peptidase activity
EZH22_31125	COG1074	ATP-dependent DNA helicase activity
EZH22_31190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EZH22_31285	COG1192	Involved in chromosome partitioning
EZH22_31295	COG3609	addiction module antidote protein, CC2985 family
EZH22_31305	COG3831	ATPase activity
EZH22_31310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EZH22_31385	COG1192	Involved in chromosome partitioning
EZH22_31395	COG3609	addiction module antidote protein, CC2985 family
EZH22_31405	COG3831	ATPase activity