locus-tag	class	description
D7006_00010	COG0268	Binds directly to 16S ribosomal RNA
D7006_00020	COG0135	phosphoribosylanthranilate isomerase activity
D7006_00025	COG0133	tryptophan synthase activity
D7006_00035	COG0159	tryptophan synthase activity
D7006_00040	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D7006_00050	COG0129	dihydroxy-acid dehydratase activity
D7006_00070	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D7006_00075	COG1877	trehalose-phosphatase activity
D7006_00090	COG5487	UPF0391 membrane protein
D7006_00115	COG0427	acetyl-CoA hydrolase
D7006_00120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D7006_00125	COG3093	addiction module antidote protein HigA
D7006_00155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D7006_00165	COG1278	Cold shock
D7006_00170	COG0778	Nitroreductase
D7006_00195	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D7006_00200	COG3158	transport of potassium into the cell
D7006_00215	COG0519	Catalyzes the synthesis of GMP from XMP
D7006_00215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D7006_00225	COG0069	glutamate synthase activity
D7006_00240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7006_00245	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D7006_00250	COG3038	cytochrome b561
D7006_00255	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D7006_00255	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D7006_00270	COG0670	Belongs to the BI1 family
D7006_00280	COG0697	spore germination
D7006_00285	COG0583	DNA-binding transcription factor activity
D7006_00290	COG0837	glucose binding
D7006_00315	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D7006_00330	COG1051	belongs to the nudix hydrolase family
D7006_00340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D7006_00355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D7006_00360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D7006_00365	COG0799	negative regulation of ribosome biogenesis
D7006_00370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D7006_00375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D7006_00395	COG3750	Belongs to the UPF0335 family
D7006_00400	COG3108	Peptidase M15
D7006_00405	COG2989	Protein conserved in bacteria
D7006_00430	COG0793	Belongs to the peptidase S41A family
D7006_00440	COG0765	amino acid transport
D7006_00445	COG0765	amino acid transport
D7006_00455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D7006_00460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D7006_00465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D7006_00470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D7006_00480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D7006_00485	COG0590	tRNA wobble adenosine to inosine editing
D7006_00490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D7006_00505	COG1116	anion transmembrane transporter activity
D7006_00510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D7006_00525	COG2855	membrane
D7006_00530	COG0583	DNA-binding transcription factor activity
D7006_00535	COG0488	(ABC) transporter
D7006_00540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D7006_00545	COG1946	Acyl-CoA thioesterase
D7006_00550	COG0347	Belongs to the P(II) protein family
D7006_00555	COG0004	ammonium transporteR
D7006_00560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D7006_00565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D7006_00575	COG0612	Peptidase, M16
D7006_00580	COG0612	Peptidase, M16
D7006_00595	COG1607	acyl-coa hydrolase
D7006_00600	COG1643	Atp-dependent helicase
D7006_00610	COG4689	acetoacetate decarboxylase
D7006_00660	COG0156	8-amino-7-oxononanoate synthase activity
D7006_00665	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D7006_00670	COG3842	ATPase activity
D7006_00675	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D7006_00680	COG4149	molybdate abc transporter
D7006_00690	COG1609	Transcriptional regulator
D7006_00710	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7006_00715	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D7006_00720	COG2086	electron transfer activity
D7006_00740	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D7006_00755	COG2183	response to ionizing radiation
D7006_00795	COG0375	protein maturation
D7006_00850	COG1764	response to oxidative stress
D7006_00855	COG1846	Transcriptional regulator
D7006_00865	COG2205	protein histidine kinase activity
D7006_00875	COG2226	methyltransferase
D7006_00880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D7006_00885	COG0528	UMP kinase activity
D7006_00890	COG0528	UMP kinase activity
D7006_00895	COG2223	nitrite transmembrane transporter activity
D7006_00905	COG3852	Histidine kinase
D7006_00920	COG0494	nUDIX hydrolase
D7006_00925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D7006_00930	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D7006_00935	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D7006_00945	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D7006_00950	COG1137	ATPase activity
D7006_00985	COG0745	RESPONSE REGULATOR receiver
D7006_00990	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D7006_01010	COG1360	Flagellar Motor Protein
D7006_01025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D7006_01030	COG1338	Plays a role in the flagellum-specific transport system
D7006_01040	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D7006_01050	COG1706	bacterial-type flagellum-dependent cell motility
D7006_01060	COG4786	Flagellar basal body rod
D7006_01065	COG1677	Flagellar hook-basal body complex protein FliE
D7006_01070	COG1558	bacterial-type flagellum-dependent cell motility
D7006_01075	COG1815	bacterial-type flagellum-dependent cell motility
D7006_01085	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D7006_01090	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D7006_01095	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D7006_01110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D7006_01120	COG4786	Flagellar basal body rod
D7006_01125	COG1157	protein secretion by the type III secretion system
D7006_01130	COG1749	Flagellar hook protein flgE
D7006_01150	COG5443	negative regulation of bacterial-type flagellum assembly
D7006_01155	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D7006_01160	COG1987	bacterial-type flagellum assembly
D7006_01165	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D7006_01170	COG1684	flagellar biosynthetic protein fliR
D7006_01195	COG0643	Histidine kinase
D7006_01195	COG0784	Response regulator, receiver
D7006_01195	COG2198	Histidine kinase
D7006_01200	COG0835	chemotaxis
D7006_01205	COG0745	RESPONSE REGULATOR receiver
D7006_01210	COG2201	protein-glutamate methylesterase activity
D7006_01225	COG0840	transmembrane signaling receptor activity
D7006_01230	COG4566	intracellular signal transduction
D7006_01265	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D7006_01270	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D7006_01300	COG0154	amidase activity
D7006_01325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D7006_01340	COG1024	Enoyl-CoA hydratase
D7006_01350	COG1902	pentaerythritol trinitrate reductase activity
D7006_01355	COG1309	transcriptional regulator
D7006_01360	COG4670	ketone body catabolic process
D7006_01370	COG0625	glutathione transferase activity
D7006_01375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D7006_01385	COG0574	Belongs to the PEP-utilizing enzyme family
D7006_01385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D7006_01400	COG2032	superoxide dismutase activity
D7006_01415	COG0644	oxidoreductase
D7006_01420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D7006_01450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7006_01455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D7006_01460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D7006_01475	COG2203	Gaf domain
D7006_01475	COG3706	GGDEF domain
D7006_01475	COG4251	negative regulation of phosphorylation
D7006_01475	COG5001	Diguanylate cyclase
D7006_01480	COG0129	dihydroxy-acid dehydratase activity
D7006_01495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D7006_01515	COG0756	dUTP diphosphatase activity
D7006_01520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D7006_01525	COG3300	MHYT domain
D7006_01525	COG5001	Diguanylate cyclase
D7006_01530	COG3604	Transcriptional regulator
D7006_01535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D7006_01540	COG0719	Fe-S assembly protein
D7006_01545	COG0396	ATPase activity
D7006_01555	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D7006_01560	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
D7006_01570	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D7006_01575	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D7006_01595	COG5420	small protein containing a coiled-coil domain
D7006_01620	COG2897	thiosulfate sulfurtransferase activity
D7006_01645	COG0316	Belongs to the HesB IscA family
D7006_01655	COG1104	cysteine desulfurase activity
D7006_01675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D7006_01695	COG5554	nitrogen fixation
D7006_01715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D7006_01730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D7006_01750	COG2151	metal-sulfur cluster biosynthetic enzyme
D7006_01765	COG2346	COG2346, Truncated hemoglobins
D7006_01790	COG0412	Dienelactone hydrolase
D7006_01800	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
D7006_01805	COG0644	oxidoreductase
D7006_01810	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D7006_01815	COG2086	electron transfer activity
D7006_01820	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
D7006_01845	COG0157	Belongs to the NadC ModD family
D7006_01865	COG0039	L-malate dehydrogenase activity
D7006_01870	COG0045	succinate-CoA ligase (ADP-forming) activity
D7006_01875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D7006_01890	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7006_01895	COG1280	lysine exporter protein (LysE YggA)
D7006_01900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7006_01910	COG1196	nuclear chromosome segregation
D7006_01910	COG3264	Mechanosensitive ion channel
D7006_01915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D7006_01925	COG2951	lytic endotransglycosylase activity
D7006_01930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D7006_01950	COG0287	Prephenate dehydrogenase
D7006_01955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D7006_01975	COG2010	Cytochrome c
D7006_01990	COG3321	synthase
D7006_01990	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_01990	COG0604	alcohol dehydrogenase
D7006_01995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7006_02020	COG2368	4-hydroxyphenylacetate
D7006_02035	COG2205	protein histidine kinase activity
D7006_02090	COG0488	(ABC) transporter
D7006_02105	COG2391	methyltransferase activity
D7006_02110	COG0446	pyridine nucleotide-disulphide oxidoreductase
D7006_02120	COG0175	sulfate reduction
D7006_02145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D7006_02150	COG2862	Uncharacterized protein family, UPF0114
D7006_02155	COG2610	gluconate transmembrane transporter activity
D7006_02175	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_02185	COG0517	IMP dehydrogenase activity
D7006_02185	COG1994	Peptidase M50
D7006_02195	COG2814	Major facilitator Superfamily
D7006_02205	COG2885	chlorophyll binding
D7006_02220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D7006_02225	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_02240	COG0129	dihydroxy-acid dehydratase activity
D7006_02250	COG1122	ATPase activity
D7006_02255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D7006_02260	COG1268	BioY protein
D7006_02265	COG0318	PFAM AMP-dependent synthetase and ligase
D7006_02305	COG0644	oxidoreductase
D7006_02315	COG0137	argininosuccinate synthase activity
D7006_02335	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D7006_02340	COG0167	dihydroorotate dehydrogenase activity
D7006_02350	COG1970	mechanosensitive ion channel activity
D7006_02355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D7006_02365	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D7006_02380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D7006_02385	COG0521	Mo-molybdopterin cofactor biosynthetic process
D7006_02420	COG0683	leucine binding
D7006_02445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_02450	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D7006_02475	COG1764	response to oxidative stress
D7006_02480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7006_02495	COG4251	negative regulation of phosphorylation
D7006_02500	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D7006_02525	COG1032	radical SAM domain protein
D7006_02535	COG3300	MHYT domain
D7006_02535	COG5001	Diguanylate cyclase
D7006_02545	COG0242	peptide deformylase activity
D7006_02560	COG2824	Alkylphosphonate utilization operon protein PhnA
D7006_02565	COG0318	PFAM AMP-dependent synthetase and ligase
D7006_02585	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D7006_02590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D7006_02595	COG2135	peptidase activity
D7006_02605	COG0546	phosphoglycolate phosphatase activity
D7006_02615	COG1376	ErfK ybiS ycfS ynhG family protein
D7006_02615	COG1388	LysM domain
D7006_02630	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_02635	COG0259	pyridoxamine-phosphate oxidase activity
D7006_02645	COG0484	heat shock protein binding
D7006_02650	COG2030	dehydratase
D7006_02665	COG1733	regulation of RNA biosynthetic process
D7006_02670	COG0604	alcohol dehydrogenase
D7006_02695	COG0730	response to heat
D7006_02700	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D7006_02710	COG3237	CsbD-like
D7006_02715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D7006_02720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D7006_02725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7006_02740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7006_02750	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D7006_02760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_02765	COG1116	anion transmembrane transporter activity
D7006_02770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_02775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D7006_02780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D7006_02785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7006_02820	COG0583	DNA-binding transcription factor activity
D7006_02825	COG1942	4-Oxalocrotonate Tautomerase
D7006_02845	COG1116	anion transmembrane transporter activity
D7006_02850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D7006_02855	COG0300	oxidoreductase activity
D7006_02865	COG1335	isochorismatase
D7006_02885	COG1414	Transcriptional regulator
D7006_02960	COG0582	viral genome integration into host DNA
D7006_02980	COG0513	Belongs to the DEAD box helicase family
D7006_03015	COG1475	DNA binding
D7006_03045	COG5489	Protein of unknown function (DUF736)
D7006_03075	COG1192	Involved in chromosome partitioning
D7006_03100	COG0741	lytic transglycosylase activity
D7006_03120	COG4962	Type ii secretion system protein e
D7006_03135	COG3451	type IV secretory pathway VirB4
D7006_03150	COG3846	protein secretion by the type IV secretion system
D7006_03165	COG2948	multi-organism process
D7006_03185	COG0640	Transcriptional regulator
D7006_03225	COG0519	Catalyzes the synthesis of GMP from XMP
D7006_03225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D7006_03275	COG1309	transcriptional regulator
D7006_03285	COG1131	(ABC) transporter
D7006_03290	COG0842	Transport permease protein
D7006_03295	COG3278	Belongs to the heme-copper respiratory oxidase family
D7006_03310	COG2010	Cytochrome c
D7006_03325	COG2217	Heavy metal translocating P-type atpase
D7006_03340	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_03345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D7006_03350	COG2967	ApaG domain
D7006_03360	COG0717	Belongs to the dCTP deaminase family
D7006_03370	COG0625	glutathione transferase activity
D7006_03375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D7006_03390	COG0247	lactate metabolic process
D7006_03395	COG0785	Cytochrome C biogenesis protein
D7006_03400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7006_03405	COG0424	maF-like protein
D7006_03410	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D7006_03415	COG1012	belongs to the aldehyde dehydrogenase family
D7006_03420	COG0500	methyltransferase
D7006_03435	COG0625	glutathione transferase activity
D7006_03440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D7006_03465	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D7006_03485	COG0436	Aminotransferase
D7006_03490	COG0625	glutathione transferase activity
D7006_03500	COG2133	pyrroloquinoline quinone binding
D7006_03525	COG0556	nucleotide-excision repair
D7006_03540	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D7006_03540	COG1618	nucleotide phosphatase activity, acting on free nucleotides
D7006_03575	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D7006_03580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D7006_03585	COG1522	sequence-specific DNA binding
D7006_03590	COG0492	ferredoxin-NADP+ reductase activity
D7006_03610	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D7006_03640	COG1921	L-seryl-tRNASec selenium transferase activity
D7006_03650	COG2864	formate dehydrogenase
D7006_03655	COG0437	4 iron, 4 sulfur cluster binding
D7006_03665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7006_03670	COG1305	Transglutaminase-like
D7006_03675	COG0709	Synthesizes selenophosphate from selenide and ATP
D7006_03690	COG1063	alcohol dehydrogenase
D7006_03710	COG2814	Major facilitator Superfamily
D7006_03720	COG2814	Major facilitator Superfamily
D7006_03725	COG0786	glutamate:sodium symporter activity
D7006_03745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D7006_03755	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D7006_03770	COG0604	alcohol dehydrogenase
D7006_03770	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_03770	COG3321	synthase
D7006_03785	COG0254	rRNA binding
D7006_03790	COG1132	(ABC) transporter
D7006_03800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D7006_03800	COG2169	Transcriptional regulator
D7006_03825	COG2358	TRAP transporter, solute receptor (TAXI family
D7006_03835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D7006_03840	COG0288	reversible hydration of carbon dioxide
D7006_03855	COG2181	nitrate reductase activity
D7006_03860	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D7006_03865	COG1140	nitrate reductase beta subunit
D7006_03870	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D7006_03875	COG2223	nitrite transmembrane transporter activity
D7006_03885	COG2271	Major facilitator Superfamily
D7006_03905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_03910	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
D7006_03940	COG2351	hydroxyisourate hydrolase activity
D7006_03950	COG1176	ABC-type spermidine putrescine transport system, permease component I
D7006_03955	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D7006_03960	COG3842	ATPase activity
D7006_03985	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D7006_03995	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7006_03995	COG1024	Enoyl-CoA hydratase
D7006_04000	COG0183	Belongs to the thiolase family
D7006_04005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D7006_04015	COG1309	transcriptional regulator
D7006_04035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7006_04040	COG0633	Ferredoxin
D7006_04070	COG0559	Belongs to the binding-protein-dependent transport system permease family
D7006_04105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D7006_04120	COG2373	Large extracellular alpha-helical protein
D7006_04125	COG4953	penicillin-binding protein 1C
D7006_04145	COG0596	Alpha beta hydrolase
D7006_04155	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_04165	COG4829	muconolactone delta-isomerase
D7006_04175	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7006_04180	COG1414	Transcriptional regulator
D7006_04190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D7006_04215	COG0247	lactate metabolic process
D7006_04215	COG2181	nitrate reductase activity
D7006_04245	COG1217	gtp-binding protein TYPA
D7006_04250	COG0579	oxidoreductase
D7006_04260	COG1053	succinate dehydrogenase
D7006_04275	COG0366	Alpha amylase catalytic
D7006_04280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D7006_04295	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_04310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D7006_04315	COG0778	Nitroreductase
D7006_04325	COG4221	oxidoreductase activity
D7006_04335	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D7006_04355	COG0483	inositol monophosphate 1-phosphatase activity
D7006_04370	COG0071	Belongs to the small heat shock protein (HSP20) family
D7006_04375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D7006_04415	COG2226	methyltransferase
D7006_04430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D7006_04435	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D7006_04440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D7006_04445	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D7006_04465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7006_04475	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D7006_04485	COG0745	RESPONSE REGULATOR receiver
D7006_04490	COG0642	Histidine kinase
D7006_04500	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7006_04500	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D7006_04510	COG3852	Histidine kinase
D7006_04525	COG2132	Multicopper oxidase
D7006_04545	COG2205	protein histidine kinase activity
D7006_04560	COG0179	Fumarylacetoacetate (FAA) hydrolase
D7006_04565	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_04570	COG2271	Major facilitator Superfamily
D7006_04575	COG4948	Mandelate Racemase Muconate Lactonizing
D7006_04595	COG1278	Cold shock
D7006_04615	COG3459	Glycosyltransferase 36 associated
D7006_04635	COG0753	catalase activity
D7006_04655	COG0784	Response regulator, receiver
D7006_04655	COG4191	Histidine kinase
D7006_04680	COG1850	ribulose-bisphosphate carboxylase activity
D7006_04705	COG0523	cobalamin synthesis protein
D7006_04715	COG1802	Transcriptional regulator
D7006_04765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_04785	COG2375	cellular response to nickel ion
D7006_04805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_04810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_04825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D7006_04835	COG1063	alcohol dehydrogenase
D7006_04850	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D7006_04855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D7006_04870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_04875	COG2188	Transcriptional regulator
D7006_04895	COG2009	succinate dehydrogenase
D7006_04910	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D7006_04940	COG0028	Belongs to the TPP enzyme family
D7006_04945	COG0477	Major facilitator Superfamily
D7006_04955	COG1414	Transcriptional regulator
D7006_04970	COG1271	oxidase subunit
D7006_04975	COG0243	molybdopterin cofactor binding
D7006_04980	COG1566	PFAM secretion protein HlyD family protein
D7006_04990	COG1289	transmembrane transporter activity
D7006_05000	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_05005	COG2010	Cytochrome c
D7006_05005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D7006_05010	COG2080	2 iron, 2 sulfur cluster binding
D7006_05015	COG2010	Cytochrome c
D7006_05015	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D7006_05025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D7006_05025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D7006_05030	COG2814	Major facilitator Superfamily
D7006_05045	COG0025	NhaP-type Na H and K H
D7006_05055	COG0783	Belongs to the Dps family
D7006_05060	COG4566	intracellular signal transduction
D7006_05065	COG4566	intracellular signal transduction
D7006_05070	COG4191	Histidine kinase
D7006_05090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D7006_05130	COG1012	belongs to the aldehyde dehydrogenase family
D7006_05150	COG2140	Oxalate decarboxylase
D7006_05155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D7006_05195	COG0145	ligase activity
D7006_05200	COG4647	ligase activity
D7006_05205	COG0145	ligase activity
D7006_05210	COG3284	Transcriptional regulator
D7006_05215	COG0523	cobalamin synthesis protein
D7006_05265	COG1192	Involved in chromosome partitioning
D7006_05295	COG1476	TRANSCRIPTIONal
D7006_05300	COG1910	domain protein
D7006_05310	COG5489	Protein of unknown function (DUF736)
D7006_05345	COG0559	Belongs to the binding-protein-dependent transport system permease family
D7006_05360	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7006_05385	COG1475	DNA binding
D7006_05470	COG5489	Protein of unknown function (DUF736)
D7006_05475	COG1476	TRANSCRIPTIONal
D7006_05505	COG1192	Involved in chromosome partitioning
D7006_05580	COG1960	acyl-CoA dehydrogenase activity
D7006_05585	COG1960	acyl-CoA dehydrogenase activity
D7006_05590	COG0183	Belongs to the thiolase family
D7006_05595	COG0318	PFAM AMP-dependent synthetase and ligase
D7006_05600	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7006_05600	COG1024	Enoyl-CoA hydratase
D7006_05635	COG1024	Enoyl-CoA hydratase
D7006_05645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7006_05660	COG2801	Transposase and inactivated derivatives
D7006_05665	COG4962	Type ii secretion system protein e
D7006_05680	COG3451	type IV secretory pathway VirB4
D7006_05710	COG2948	multi-organism process
D7006_05720	COG0583	DNA-binding transcription factor activity
D7006_05760	COG0488	(ABC) transporter
D7006_05790	COG2205	protein histidine kinase activity
D7006_05800	COG2166	iron-sulfur cluster assembly
D7006_05830	COG0151	Belongs to the GarS family
D7006_05835	COG1570	exodeoxyribonuclease VII activity
D7006_05845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D7006_05855	COG2818	Glycosylase
D7006_05885	COG0277	FAD linked oxidase domain protein
D7006_05900	COG2264	protein methyltransferase activity
D7006_05905	COG3706	GGDEF domain
D7006_05910	COG0210	DNA helicase
D7006_05935	COG0628	permease
D7006_05940	COG2902	Dehydrogenase
D7006_05980	COG3135	benzoate transporter
D7006_05990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D7006_06025	COG0248	Ppx GppA phosphatase
D7006_06030	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D7006_06040	COG0628	permease
D7006_06050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D7006_06060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D7006_06065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7006_06070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D7006_06075	COG1561	YicC-like family, N-terminal region
D7006_06080	COG0194	GDP metabolic process
D7006_06085	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D7006_06090	COG3300	MHYT domain
D7006_06090	COG5001	Diguanylate cyclase
D7006_06095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D7006_06110	COG0280	phosphate acetyltransferase
D7006_06110	COG0281	malic enzyme
D7006_06115	COG3161	chorismate lyase activity
D7006_06150	COG4695	Portal protein
D7006_06175	COG0741	lytic transglycosylase activity
D7006_06180	COG5640	endopeptidase activity
D7006_06295	COG2095	MarC family integral membrane protein
D7006_06305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D7006_06320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D7006_06330	COG1960	acyl-CoA dehydrogenase activity
D7006_06335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D7006_06340	COG0346	lactoylglutathione lyase activity
D7006_06350	COG0602	queuosine metabolic process
D7006_06355	COG0720	synthase
D7006_06360	COG0431	NADPH-dependent FMN reductase
D7006_06380	COG2132	Multicopper oxidase
D7006_06390	COG0672	)-iron permease
D7006_06400	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D7006_06405	COG4149	molybdate abc transporter
D7006_06410	COG0725	ABC transporter, periplasmic molybdate-binding protein
D7006_06415	COG0586	Pfam SNARE associated Golgi protein
D7006_06420	COG0513	Belongs to the DEAD box helicase family
D7006_06425	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D7006_06430	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D7006_06435	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D7006_06440	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_06445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D7006_06460	COG0559	Belongs to the binding-protein-dependent transport system permease family
D7006_06485	COG2186	Transcriptional regulator
D7006_06500	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
D7006_06505	COG3454	Phosphonate metabolism
D7006_06510	COG4778	phosphonate C-P lyase system protein PhnL
D7006_06515	COG4107	phosphonate C-P lyase system protein PhnK
D7006_06525	COG3626	phosphonate metabolism
D7006_06530	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
D7006_06535	COG3624	Phosphonate C-P lyase system protein PhnG
D7006_06540	COG2188	Transcriptional regulator
D7006_06565	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D7006_06570	COG0154	amidase activity
D7006_06575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D7006_06580	COG1760	l-serine dehydratase
D7006_06590	COG3979	chitinase
D7006_06600	COG2072	flavoprotein involved in K transport
D7006_06615	COG0667	Aldo Keto reductase
D7006_06635	COG0601	transmembrane transport
D7006_06640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7006_06650	COG4608	Belongs to the ABC transporter superfamily
D7006_06655	COG0667	Aldo Keto reductase
D7006_06660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7006_06665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7006_06685	COG1116	anion transmembrane transporter activity
D7006_06690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_06700	COG1464	Belongs to the NlpA lipoprotein family
D7006_06720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7006_06725	COG3685	Protein conserved in bacteria
D7006_06730	COG1959	2 iron, 2 sulfur cluster binding
D7006_06735	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7006_06750	COG1573	uracil-dna glycosylase
D7006_06770	COG2205	protein histidine kinase activity
D7006_06770	COG2202	Pas domain
D7006_06775	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D7006_06785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D7006_06805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D7006_06815	COG0433	COG0433 Predicted ATPase
D7006_06850	COG1335	isochorismatase
D7006_06865	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D7006_06910	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_06915	COG0179	Fumarylacetoacetate (FAA) hydrolase
D7006_06925	COG1024	Enoyl-CoA hydratase
D7006_06935	COG0583	DNA-binding transcription factor activity
D7006_06945	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D7006_06960	COG1960	acyl-CoA dehydrogenase activity
D7006_07015	COG0583	DNA-binding transcription factor activity
D7006_07020	COG2943	transferase activity, transferring hexosyl groups
D7006_07025	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
D7006_07030	COG0318	PFAM AMP-dependent synthetase and ligase
D7006_07035	COG1024	Enoyl-CoA hydratase
D7006_07050	COG2186	Transcriptional regulator
D7006_07055	COG0604	alcohol dehydrogenase
D7006_07065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D7006_07070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D7006_07110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_07120	COG1116	anion transmembrane transporter activity
D7006_07125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_07135	COG0523	cobalamin synthesis protein
D7006_07155	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_07165	COG0673	inositol 2-dehydrogenase activity
D7006_07170	COG3842	ATPase activity
D7006_07190	COG0129	dihydroxy-acid dehydratase activity
D7006_07195	COG3618	amidohydrolase
D7006_07200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D7006_07215	COG1802	Transcriptional regulator
D7006_07220	COG3181	Tripartite tricarboxylate transporter family receptor
D7006_07225	COG4948	Mandelate Racemase Muconate Lactonizing
D7006_07230	COG0179	Fumarylacetoacetate (FAA) hydrolase
D7006_07235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D7006_07240	COG4948	Mandelate Racemase Muconate Lactonizing
D7006_07260	COG0489	protein tyrosine kinase activity
D7006_07265	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D7006_07275	COG0752	glycyl-tRNA synthetase alpha subunit
D7006_07350	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
D7006_07355	COG1797	cobyrinic acid a,c-diamide synthase activity
D7006_07360	COG1280	lysine exporter protein (LysE YggA)
D7006_07380	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7006_07385	COG0842	Transport permease protein
D7006_07390	COG1131	(ABC) transporter
D7006_07410	COG1960	acyl-CoA dehydrogenase activity
D7006_07415	COG0009	L-threonylcarbamoyladenylate synthase
D7006_07420	COG0456	acetyltransferase
D7006_07425	COG0123	including yeast histone deacetylase and acetoin utilization protein
D7006_07445	COG4770	biotin carboxylase activity
D7006_07450	COG3665	Urea carboxylase-associated protein
D7006_07455	COG3665	Urea carboxylase-associated protein
D7006_07460	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D7006_07480	COG0628	permease
D7006_07490	COG5328	Belongs to the UPF0262 family
D7006_07500	COG3300	MHYT domain
D7006_07500	COG5001	Diguanylate cyclase
D7006_07530	COG1137	ATPase activity
D7006_07540	COG0693	protein deglycase activity
D7006_07545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D7006_07550	COG0358	DNA primase activity
D7006_07555	COG2827	Endonuclease containing a URI domain
D7006_07560	COG1115	amino acid carrier protein
D7006_07570	COG0505	Belongs to the CarA family
D7006_07575	COG1802	Transcriptional regulator
D7006_07585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7006_07605	COG0166	Belongs to the GPI family
D7006_07610	COG0363	glucosamine-6-phosphate deaminase activity
D7006_07615	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D7006_07620	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D7006_07630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D7006_07640	COG1560	Kdo2-lipid A biosynthetic process
D7006_07655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7006_07660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7006_07665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D7006_07670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D7006_07675	COG2321	neutral zinc metallopeptidase
D7006_07680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D7006_07690	COG1294	oxidase, subunit
D7006_07695	COG1271	oxidase subunit
D7006_07700	COG2814	Major facilitator Superfamily
D7006_07705	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_07710	COG1477	protein flavinylation
D7006_07745	COG0410	ABC transporter
D7006_07750	COG0411	ABC transporter
D7006_07755	COG0559	Belongs to the binding-protein-dependent transport system permease family
D7006_07770	COG1309	transcriptional regulator
D7006_07775	COG0154	amidase activity
D7006_07780	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D7006_07805	COG0583	DNA-binding transcription factor activity
D7006_07815	COG0154	amidase activity
D7006_07850	COG0318	PFAM AMP-dependent synthetase and ligase
D7006_07860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D7006_07865	COG1024	Enoyl-CoA hydratase
D7006_07885	COG3284	Transcriptional regulator
D7006_07890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D7006_07895	COG0022	dehydrogenase e1 component
D7006_07900	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7006_07900	COG0596	Alpha beta hydrolase
D7006_07910	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7006_07915	COG1063	alcohol dehydrogenase
D7006_07935	COG4774	siderophore transport
D7006_08005	COG0582	viral genome integration into host DNA
D7006_08020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D7006_08065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D7006_08085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D7006_08105	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D7006_08115	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D7006_08120	COG0081	regulation of translation
D7006_08125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D7006_08130	COG0222	ribosome binding
D7006_08135	COG0085	RNA polymerase activity
D7006_08140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D7006_08145	COG0531	amino acid
D7006_08160	COG1032	radical SAM domain protein
D7006_08165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7006_08200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D7006_08205	COG0583	DNA-binding transcription factor activity
D7006_08210	COG0477	Major facilitator Superfamily
D7006_08215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7006_08240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D7006_08245	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D7006_08245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D7006_08250	COG0318	PFAM AMP-dependent synthetase and ligase
D7006_08260	COG0183	Belongs to the thiolase family
D7006_08265	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D7006_08270	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
D7006_08290	COG1176	ABC-type spermidine putrescine transport system, permease component I
D7006_08295	COG3842	ATPase activity
D7006_08305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D7006_08325	COG3842	ATPase activity
D7006_08330	COG1176	ABC-type spermidine putrescine transport system, permease component I
D7006_08335	COG1177	transmembrane transport
D7006_08360	COG0714	Associated with various cellular activities
D7006_08370	COG0494	nUDIX hydrolase
D7006_08380	COG0617	tRNA 3'-terminal CCA addition
D7006_08390	COG0408	coproporphyrinogen oxidase activity
D7006_08395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D7006_08405	COG0723	plastoquinol--plastocyanin reductase activity
D7006_08410	COG2857	Cytochrome c1
D7006_08410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D7006_08415	COG2857	Cytochrome c1
D7006_08415	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D7006_08420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D7006_08425	COG2003	Belongs to the UPF0758 family
D7006_08430	COG0024	Methionine aminopeptidase
D7006_08435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D7006_08440	COG0483	inositol monophosphate 1-phosphatase activity
D7006_08445	COG0823	Involved in the tonB-independent uptake of proteins
D7006_08460	COG0811	peptide transport
D7006_08465	COG0824	Thioesterase
D7006_08480	COG2255	four-way junction helicase activity
D7006_08490	COG0632	four-way junction helicase activity
D7006_08500	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D7006_08510	COG0789	Transcriptional regulator
D7006_08515	COG0217	transcriptional regulatory protein
D7006_08520	COG1692	metallophosphoesterase
D7006_08560	COG3588	fructose-bisphosphate aldolase
D7006_08565	COG0352	thiamine-phosphate diphosphorylase activity
D7006_08575	COG2885	chlorophyll binding
D7006_08585	COG0037	tRNA processing
D7006_08590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D7006_08595	COG0728	peptidoglycan biosynthetic process
D7006_08600	COG0180	Tryptophanyl-tRNA synthetase
D7006_08605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D7006_08615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D7006_08625	COG1040	competence protein
D7006_08635	COG1937	Protein conserved in bacteria
D7006_08640	COG0742	ribosomal rna small subunit methyltransferase
D7006_08645	COG1187	pseudouridine synthase activity
D7006_08650	COG0590	tRNA wobble adenosine to inosine editing
D7006_08655	COG0596	Alpha beta hydrolase
D7006_08675	COG1489	DNA binding
D7006_08695	COG0359	binds to the 23S rRNA
D7006_08705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D7006_08710	COG0360	Binds together with S18 to 16S ribosomal RNA
D7006_08715	COG0726	polysaccharide deacetylase
D7006_08720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D7006_08735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D7006_08745	COG0495	leucyl-tRNA aminoacylation
D7006_08765	COG2223	nitrite transmembrane transporter activity
D7006_08775	COG0432	Pfam Uncharacterised protein family UPF0047
D7006_08780	COG0657	acetylesterase activity
D7006_08810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D7006_08815	COG0228	four-way junction DNA binding
D7006_08825	COG0596	Alpha beta hydrolase
D7006_08835	COG0534	Mate efflux family protein
D7006_08855	COG1793	dna ligase
D7006_08855	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D7006_08865	COG1793	dna ligase
D7006_08865	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D7006_08875	COG2814	Major facilitator Superfamily
D7006_08885	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D7006_08890	COG0494	nUDIX hydrolase
D7006_08905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D7006_08915	COG1663	tetraacyldisaccharide 4'-kinase activity
D7006_08920	COG1519	Transferase
D7006_08935	COG0483	inositol monophosphate 1-phosphatase activity
D7006_08940	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D7006_08950	COG4106	trans-aconitate 2-methyltransferase activity
D7006_08955	COG0028	Belongs to the TPP enzyme family
D7006_08965	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D7006_08995	COG0559	Belongs to the binding-protein-dependent transport system permease family
D7006_09015	COG1022	Amp-dependent synthetase and ligase
D7006_09020	COG0183	Belongs to the thiolase family
D7006_09025	COG1024	Enoyl-CoA hydratase
D7006_09025	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7006_09050	COG0444	Belongs to the ABC transporter superfamily
D7006_09055	COG0154	amidase activity
D7006_09065	COG4608	Belongs to the ABC transporter superfamily
D7006_09070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7006_09075	COG0601	transmembrane transport
D7006_09080	COG4166	transmembrane transport
D7006_09095	COG0625	glutathione transferase activity
D7006_09130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D7006_09135	COG1230	cation diffusion facilitator family transporter
D7006_09145	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D7006_09150	COG3383	formate dehydrogenase (NAD+) activity
D7006_09165	COG0583	DNA-binding transcription factor activity
D7006_09190	COG1218	3'(2'),5'-bisphosphate nucleotidase
D7006_09210	COG0745	RESPONSE REGULATOR receiver
D7006_09230	COG3706	GGDEF domain
D7006_09235	COG0010	Belongs to the arginase family
D7006_09240	COG0387	Pfam Sodium calcium exchanger
D7006_09255	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D7006_09260	COG0436	Aminotransferase
D7006_09275	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D7006_09280	COG0511	ligase activity, forming carbon-carbon bonds
D7006_09290	COG0800	Aldolase
D7006_09295	COG1012	belongs to the aldehyde dehydrogenase family
D7006_09310	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D7006_09320	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D7006_09330	COG2423	ornithine cyclodeaminase activity
D7006_09335	COG0386	Belongs to the glutathione peroxidase family
D7006_09345	COG0145	ligase activity
D7006_09350	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
D7006_09355	COG4647	ligase activity
D7006_09370	COG2267	carboxylic ester hydrolase activity
D7006_09385	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D7006_09400	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D7006_09405	COG0560	Phosphoserine phosphatase
D7006_09415	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D7006_09420	COG3045	CreA protein
D7006_09435	COG0215	cysteine-tRNA ligase activity
D7006_09445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D7006_09450	COG2259	Doxx family
D7006_09455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7006_09465	COG1309	transcriptional regulator
D7006_09475	COG0523	cobalamin synthesis protein
D7006_09480	COG0803	Belongs to the bacterial solute-binding protein 9 family
D7006_09515	COG0446	pyridine nucleotide-disulphide oxidoreductase
D7006_09515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D7006_09525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7006_09540	COG2885	chlorophyll binding
D7006_09560	COG0069	glutamate synthase activity
D7006_09565	COG2218	PFAM glutamate synthase alpha subunit domain protein
D7006_09570	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D7006_09585	COG1032	radical SAM domain protein
D7006_09595	COG0400	carboxylic ester hydrolase activity
D7006_09600	COG0346	lactoylglutathione lyase activity
D7006_09620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D7006_09625	COG1116	anion transmembrane transporter activity
D7006_09630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_09655	COG4149	molybdate abc transporter
D7006_09660	COG1840	ABC-type Fe3 transport system, periplasmic component
D7006_09695	COG0859	PFAM glycosyl transferase family 9
D7006_09715	COG1492	cobalamin metabolic process
D7006_09745	COG3768	UPF0283 membrane protein
D7006_09750	COG0785	Cytochrome C biogenesis protein
D7006_09755	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D7006_09760	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D7006_09800	COG1254	Belongs to the acylphosphatase family
D7006_09815	COG0625	glutathione transferase activity
D7006_09845	COG0697	spore germination
D7006_09860	COG2885	chlorophyll binding
D7006_09860	COG3047	cAMP biosynthetic process
D7006_09875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7006_09880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D7006_09895	COG1573	uracil-dna glycosylase
D7006_09905	COG1758	RNA polymerase activity
D7006_09915	COG0679	Auxin Efflux Carrier
D7006_09920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D7006_09930	COG0400	carboxylic ester hydrolase activity
D7006_09940	COG2897	thiosulfate sulfurtransferase activity
D7006_09950	COG0415	Belongs to the DNA photolyase family
D7006_09955	COG0477	Major facilitator Superfamily
D7006_09960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D7006_09985	COG2199	diguanylate cyclase activity
D7006_09985	COG2200	EAL domain
D7006_09985	COG2202	Pas domain
D7006_09995	COG1530	ribonuclease E activity
D7006_09995	COG1530	ribonuclease E activity
D7006_10000	COG0860	N-Acetylmuramoyl-L-alanine amidase
D7006_10005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7006_10010	COG1024	Enoyl-CoA hydratase
D7006_10015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D7006_10025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D7006_10055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D7006_10085	COG4302	ethanolamine ammonia-lyase activity
D7006_10090	COG4303	Ethanolamine ammonia lyase large subunit
D7006_10110	COG1116	anion transmembrane transporter activity
D7006_10115	COG3634	alkyl hydroperoxide reductase activity
D7006_10125	COG0438	transferase activity, transferring glycosyl groups
D7006_10130	COG0438	transferase activity, transferring glycosyl groups
D7006_10135	COG0156	8-amino-7-oxononanoate synthase activity
D7006_10140	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_10140	COG0604	alcohol dehydrogenase
D7006_10140	COG3321	synthase
D7006_10220	COG0457	Tetratricopeptide repeat
D7006_10235	COG0642	Histidine kinase
D7006_10240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_10245	COG1116	anion transmembrane transporter activity
D7006_10260	COG2202	Pas domain
D7006_10260	COG3920	Histidine kinase
D7006_10285	COG2197	response regulator
D7006_10290	COG0251	oxidation-reduction process
D7006_10315	COG0559	Belongs to the binding-protein-dependent transport system permease family
D7006_10335	COG2188	Transcriptional regulator
D7006_10395	COG1136	(ABC) transporter
D7006_10405	COG1116	anion transmembrane transporter activity
D7006_10420	COG0411	ABC transporter
D7006_10440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D7006_10445	COG0318	PFAM AMP-dependent synthetase and ligase
D7006_10450	COG1309	transcriptional regulator
D7006_10485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D7006_10490	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D7006_10510	COG3263	regulation of cellular component size
D7006_10530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D7006_10535	COG2755	lipolytic protein G-D-S-L family
D7006_10535	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D7006_10540	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D7006_10540	COG2755	lipolytic protein G-D-S-L family
D7006_10550	COG1960	acyl-CoA dehydrogenase activity
D7006_10555	COG1024	Enoyl-CoA hydratase
D7006_10555	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7006_10560	COG0183	Belongs to the thiolase family
D7006_10570	COG2067	long-chain fatty acid transport protein
D7006_10575	COG0318	PFAM AMP-dependent synthetase and ligase
D7006_10580	COG0052	Belongs to the universal ribosomal protein uS2 family
D7006_10585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D7006_10590	COG0528	UMP kinase activity
D7006_10595	COG0233	cytoplasmic translational termination
D7006_10610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D7006_10615	COG0750	zinc metalloprotease
D7006_10620	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D7006_10625	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D7006_10630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D7006_10635	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D7006_10640	COG3494	Protein of unknown function (DUF1009)
D7006_10645	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D7006_10650	COG0372	Belongs to the citrate synthase family
D7006_10655	COG0746	molybdenum cofactor guanylyltransferase activity
D7006_10680	COG2239	Acts as a magnesium transporter
D7006_10710	COG5265	(ABC) transporter
D7006_10720	COG4941	Belongs to the sigma-70 factor family
D7006_10725	COG3795	YCII-related domain
D7006_10730	COG1472	Belongs to the glycosyl hydrolase 3 family
D7006_10735	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D7006_10740	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D7006_10745	COG3842	ATPase activity
D7006_10750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D7006_10755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D7006_10760	COG0805	protein transport
D7006_10765	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D7006_10770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D7006_10775	COG1862	Preprotein translocase
D7006_10780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D7006_10790	COG3737	Protein of unknown function (DUF498/DUF598)
D7006_10800	COG0343	queuine tRNA-ribosyltransferase activity
D7006_10805	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D7006_10810	COG3932	Exopolysaccharide synthesis, ExoD
D7006_10815	COG5425	PFAM Usg family protein
D7006_10820	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D7006_10825	COG0459	protein refolding
D7006_10835	COG0848	biopolymer transport protein
D7006_10845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D7006_10850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D7006_10855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D7006_10855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D7006_10865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D7006_10870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D7006_10875	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D7006_10905	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D7006_10910	COG0148	phosphopyruvate hydratase activity
D7006_10915	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7006_10920	COG2095	MarC family integral membrane protein
D7006_10925	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D7006_10945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D7006_10985	COG2226	methyltransferase
D7006_10990	COG0824	Thioesterase
D7006_11005	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
D7006_11015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D7006_11020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D7006_11030	COG2301	Belongs to the HpcH HpaI aldolase family
D7006_11040	COG0679	Auxin Efflux Carrier
D7006_11045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D7006_11050	COG0861	Integral membrane protein TerC family
D7006_11055	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_11070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D7006_11075	COG0736	holo-[acyl-carrier-protein] synthase activity
D7006_11080	COG0681	Belongs to the peptidase S26 family
D7006_11085	COG0571	ribonuclease III activity
D7006_11090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D7006_11100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D7006_11105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D7006_11110	COG3706	GGDEF domain
D7006_11115	COG2832	Protein of unknown function (DUF454)
D7006_11120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D7006_11125	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D7006_11140	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D7006_11145	COG2329	Antibiotic biosynthesis monooxygenase
D7006_11155	COG4558	Periplasmic binding protein
D7006_11160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7006_11165	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D7006_11170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D7006_11180	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D7006_11185	COG2860	membrane
D7006_11195	COG2252	PERMEase
D7006_11205	COG0504	CTP synthase activity
D7006_11250	COG2010	Cytochrome c
D7006_11250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D7006_11255	COG2080	2 iron, 2 sulfur cluster binding
D7006_11300	COG1846	Transcriptional regulator
D7006_11310	COG3634	alkyl hydroperoxide reductase activity
D7006_11315	COG0583	DNA-binding transcription factor activity
D7006_11320	COG4191	Histidine kinase
D7006_11335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D7006_11340	COG1609	Transcriptional regulator
D7006_11345	COG0765	amino acid transport
D7006_11350	COG0765	amino acid transport
D7006_11360	COG1126	abc transporter atp-binding protein
D7006_11365	COG3734	2-keto-3-deoxy-galactonokinase
D7006_11370	COG0800	Aldolase
D7006_11375	COG2186	Transcriptional regulator
D7006_11395	COG2814	Major facilitator Superfamily
D7006_11400	COG4221	oxidoreductase activity
D7006_11425	COG4319	ketosteroid isomerase
D7006_11455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D7006_11495	COG1686	Belongs to the peptidase S11 family
D7006_11500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D7006_11505	COG0470	DNA polymerase III
D7006_11520	COG1268	BioY protein
D7006_11525	COG0084	hydrolase, TatD family'
D7006_11530	COG1832	CoA-binding protein
D7006_11540	COG0583	DNA-binding transcription factor activity
D7006_11545	COG1380	Effector of murein hydrolase LrgA
D7006_11550	COG1346	cytolysis
D7006_11555	COG1612	heme a metabolic process
D7006_11570	COG1024	Enoyl-CoA hydratase
D7006_11580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D7006_11585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D7006_11610	COG0628	permease
D7006_11625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D7006_11630	COG1381	Involved in DNA repair and RecF pathway recombination
D7006_11640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D7006_11650	COG0022	dehydrogenase e1 component
D7006_11650	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7006_11660	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7006_11675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7006_11685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D7006_11690	COG2867	negative regulation of translational initiation
D7006_11700	COG0683	leucine binding
D7006_11705	COG0683	leucine binding
D7006_11755	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D7006_11760	COG3548	integral membrane protein
D7006_11770	COG1960	acyl-CoA dehydrogenase activity
D7006_11780	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D7006_11800	COG0629	single-stranded DNA binding
D7006_11810	COG1280	lysine exporter protein (LysE YggA)
D7006_11815	COG0514	ATP-dependent DNA helicase (RecQ)
D7006_11830	COG0730	response to heat
D7006_11835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D7006_11875	COG0656	L-ascorbic acid biosynthetic process
D7006_11895	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D7006_11915	COG0416	fatty acid biosynthetic process
D7006_11920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D7006_11925	COG0776	regulation of translation
D7006_11935	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D7006_11945	COG0321	lipoyl(octanoyl) transferase activity
D7006_11945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D7006_11955	COG3956	TIGRFAM MazG family protein
D7006_11960	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D7006_11965	COG1923	regulation of RNA biosynthetic process
D7006_11970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D7006_11980	COG0569	domain protein
D7006_11985	COG2204	response regulator
D7006_11990	COG5000	phosphorelay sensor kinase activity
D7006_12000	COG2204	response regulator
D7006_12015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D7006_12015	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D7006_12020	COG1058	Belongs to the CinA family
D7006_12020	COG1546	Belongs to the CinA family
D7006_12030	COG0018	arginyl-trna synthetase
D7006_12035	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D7006_12040	COG0316	Belongs to the HesB IscA family
D7006_12070	COG0525	valine-tRNA ligase activity
D7006_12085	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D7006_12100	COG1216	Glycosyl transferase, family 2
D7006_12100	COG0463	Glycosyl transferase, family 2
D7006_12110	COG1132	(ABC) transporter
D7006_12160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D7006_12190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D7006_12210	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D7006_12215	COG0830	nickel cation binding
D7006_12220	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D7006_12225	COG0783	Belongs to the Dps family
D7006_12230	COG0804	urea catabolic process
D7006_12235	COG0831	urea catabolic process
D7006_12235	COG0832	Belongs to the urease beta subunit family
D7006_12240	COG0829	nickel cation binding
D7006_12275	COG2239	Acts as a magnesium transporter
D7006_12290	COG0477	Major facilitator Superfamily
D7006_12305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D7006_12315	COG0406	alpha-ribazole phosphatase activity
D7006_12325	COG1253	flavin adenine dinucleotide binding
D7006_12330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D7006_12350	COG0321	lipoyl(octanoyl) transferase activity
D7006_12355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D7006_12365	COG0154	amidase activity
D7006_12370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D7006_12385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D7006_12400	COG0540	Belongs to the ATCase OTCase family
D7006_12410	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D7006_12415	COG0758	DNA mediated transformation
D7006_12425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D7006_12430	COG0477	Major facilitator Superfamily
D7006_12445	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D7006_12450	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D7006_12450	COG3608	succinylglutamate desuccinylase aspartoacylase
D7006_12460	COG1509	lysine 2,3-aminomutase activity
D7006_12480	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D7006_12485	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D7006_12490	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D7006_12505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D7006_12515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D7006_12520	COG0134	indole-3-glycerol-phosphate synthase activity
D7006_12530	COG0315	cyclic pyranopterin monophosphate synthase activity
D7006_12535	COG0303	'Molybdopterin
D7006_12540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D7006_12550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D7006_12560	COG1473	amidohydrolase
D7006_12575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D7006_12575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D7006_12585	COG0024	Methionine aminopeptidase
D7006_12590	COG1304	FMN binding
D7006_12600	COG1131	(ABC) transporter
D7006_12610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D7006_12620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7006_12645	COG0633	Ferredoxin
D7006_12655	COG3191	aminopeptidase activity
D7006_12675	COG3106	COG3106 Predicted ATPase
D7006_12690	COG1127	ABC transporter
D7006_12695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D7006_12700	COG4948	Mandelate Racemase Muconate Lactonizing
D7006_12715	COG0438	transferase activity, transferring glycosyl groups
D7006_12745	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D7006_12780	COG1891	lyase activity
D7006_12785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D7006_12790	COG2154	pterin-4-alpha-carbinolamine dehydratase
D7006_12805	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D7006_12815	COG1686	Belongs to the peptidase S11 family
D7006_12830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D7006_12840	COG0626	cystathionine gamma-synthase activity
D7006_12845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7006_12850	COG4597	amino acid ABC transporter
D7006_12855	COG0765	amino acid transport
D7006_12860	COG1126	abc transporter atp-binding protein
D7006_12870	COG1215	transferase activity, transferring glycosyl groups
D7006_12895	COG0351	phosphomethylpyrimidine kinase
D7006_12900	COG1396	sequence-specific DNA binding
D7006_12930	COG1136	(ABC) transporter
D7006_12940	COG0442	prolyl-tRNA aminoacylation
D7006_12950	COG2151	metal-sulfur cluster biosynthetic enzyme
D7006_12955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D7006_12960	COG0719	Fe-S assembly protein
D7006_12965	COG0396	ATPase activity
D7006_12970	COG0719	Fe-S assembly protein
D7006_12975	COG1104	cysteine desulfurase activity
D7006_12980	COG2945	thiolester hydrolase activity
D7006_12985	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D7006_12990	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D7006_12995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D7006_13005	COG1971	Probably functions as a manganese efflux pump
D7006_13010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D7006_13020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D7006_13025	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D7006_13035	COG0047	phosphoribosylformylglycinamidine synthase activity
D7006_13040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D7006_13050	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D7006_13060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D7006_13065	COG3300	MHYT domain
D7006_13065	COG5001	Diguanylate cyclase
D7006_13085	COG0134	indole-3-glycerol-phosphate synthase activity
D7006_13095	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_13105	COG4122	O-methyltransferase activity
D7006_13115	COG1024	Enoyl-CoA hydratase
D7006_13120	COG0113	porphobilinogen synthase activity
D7006_13125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D7006_13130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D7006_13140	COG0557	exoribonuclease II activity
D7006_13160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D7006_13170	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D7006_13205	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D7006_13210	COG4133	protoheme IX ABC transporter activity
D7006_13215	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D7006_13235	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D7006_13245	COG0667	Aldo Keto reductase
D7006_13250	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D7006_13255	COG0110	maltose O-acetyltransferase activity
D7006_13265	COG0297	glycogen (starch) synthase activity
D7006_13280	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D7006_13280	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D7006_13290	COG0297	glycogen (starch) synthase activity
D7006_13295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D7006_13300	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D7006_13310	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D7006_13320	COG2942	2-epimerase
D7006_13325	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D7006_13330	COG1088	dTDP-glucose 4,6-dehydratase activity
D7006_13335	COG1091	dTDP-4-dehydrorhamnose reductase activity
D7006_13355	COG2963	transposase activity
D7006_13360	COG3436	PFAM IS66 Orf2 family protein
D7006_13385	COG0489	protein tyrosine kinase activity
D7006_13385	COG3206	protein involved in exopolysaccharide biosynthesis
D7006_13415	COG1546	Belongs to the CinA family
D7006_13415	COG1058	Belongs to the CinA family
D7006_13420	COG2308	Evidence 4 Homologs of previously reported genes of
D7006_13435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D7006_13440	COG0537	adenosine 5'-monophosphoramidase activity
D7006_13465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D7006_13475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D7006_13475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D7006_13480	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D7006_13485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D7006_13490	COG1215	transferase activity, transferring glycosyl groups
D7006_13510	COG0776	regulation of translation
D7006_13515	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D7006_13520	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D7006_13525	COG0740	serine-type endopeptidase activity
D7006_13530	COG0544	peptidyl-prolyl cis-trans isomerase activity
D7006_13545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D7006_13545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D7006_13550	COG0347	Belongs to the P(II) protein family
D7006_13555	COG0174	glutamine synthetase
D7006_13565	COG0538	isocitrate dehydrogenase activity
D7006_13570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D7006_13580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D7006_13585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D7006_13620	COG0683	leucine binding
D7006_13630	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_13635	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_13650	COG0179	Fumarylacetoacetate (FAA) hydrolase
D7006_13670	COG0625	glutathione transferase activity
D7006_13675	COG0625	glutathione transferase activity
D7006_13710	COG0583	DNA-binding transcription factor activity
D7006_13730	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D7006_13755	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
D7006_13760	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D7006_13775	COG1595	DNA-templated transcription, initiation
D7006_13790	COG0596	Alpha beta hydrolase
D7006_13805	COG0183	Belongs to the thiolase family
D7006_13815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D7006_13840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7006_13845	COG0601	transmembrane transport
D7006_13850	COG0747	negative chemotaxis
D7006_13865	COG2111	Na H antiporter
D7006_13865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D7006_13870	COG1006	Multisubunit Na H antiporter MnhC subunit
D7006_13875	COG0651	ATP synthesis coupled electron transport
D7006_13885	COG2212	antiporter activity
D7006_13890	COG1320	monovalent cation:proton antiporter activity
D7006_13900	COG2819	hydrolase of the alpha beta superfamily
D7006_13915	COG4607	ABC-type enterochelin transport system periplasmic component
D7006_13920	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7006_13925	COG4605	iron ion homeostasis
D7006_13930	COG4604	ABC transporter, ATP-binding protein
D7006_13950	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_13955	COG3433	isochorismatase activity
D7006_13955	COG1535	isochorismatase
D7006_13960	COG1021	2,3-dihydroxybenzoate-AMP ligase
D7006_13965	COG1169	isochorismate synthase
D7006_13970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7006_13980	COG1535	isochorismatase
D7006_13980	COG3433	isochorismatase activity
D7006_13985	COG0577	efflux transmembrane transporter activity
D7006_13985	COG1136	(ABC) transporter
D7006_13990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7006_14075	COG1802	Transcriptional regulator
D7006_14100	COG3971	2-oxopent-4-enoate hydratase activity
D7006_14105	COG4569	acetaldehyde dehydrogenase (acetylating) activity
D7006_14110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D7006_14120	COG1942	4-Oxalocrotonate Tautomerase
D7006_14335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D7006_14335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D7006_14380	COG3617	BRO family, N-terminal domain
D7006_14425	COG0316	Belongs to the HesB IscA family
D7006_14430	COG5001	Diguanylate cyclase
D7006_14440	COG0346	lactoylglutathione lyase activity
D7006_14455	COG1007	ATP synthesis coupled electron transport
D7006_14470	COG0713	ATP synthesis coupled electron transport
D7006_14480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D7006_14485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D7006_14495	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D7006_14505	COG0649	NAD binding
D7006_14510	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D7006_14515	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D7006_14550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D7006_14560	COG0640	Transcriptional regulator
D7006_14575	COG3346	SURF1 family
D7006_14590	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D7006_14600	COG0109	protoheme IX farnesyltransferase activity
D7006_14605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D7006_14610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D7006_14610	COG1565	acr, cog1565
D7006_14620	COG0475	glutathione-regulated potassium exporter activity
D7006_14620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D7006_14640	COG0583	DNA-binding transcription factor activity
D7006_14645	COG1802	Transcriptional regulator
D7006_14670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7006_14675	COG0601	transmembrane transport
D7006_14690	COG0688	phosphatidylethanolamine metabolic process
D7006_14695	COG2207	Transcriptional regulator
D7006_14705	COG0183	Belongs to the thiolase family
D7006_14710	COG1960	acyl-CoA dehydrogenase activity
D7006_14715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7006_14755	COG0411	ABC transporter
D7006_14760	COG1137	ATPase activity
D7006_14780	COG1393	Belongs to the ArsC family
D7006_14805	COG0559	Belongs to the binding-protein-dependent transport system permease family
D7006_14830	COG1309	transcriptional regulator
D7006_14850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D7006_14855	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D7006_14870	COG0612	Peptidase, M16
D7006_14885	COG3243	poly(R)-hydroxyalkanoic acid synthase
D7006_14895	COG0436	Aminotransferase
D7006_14905	COG1494	fructose-1,6-bisphosphatase
D7006_14910	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D7006_14920	COG2610	gluconate transmembrane transporter activity
D7006_14925	COG2610	gluconate transmembrane transporter activity
D7006_14930	COG1192	Involved in chromosome partitioning
D7006_14940	COG3619	membrane
D7006_14950	COG0187	DNA topoisomerase II activity
D7006_14960	COG0583	DNA-binding transcription factor activity
D7006_14965	COG0667	Aldo Keto reductase
D7006_14970	COG2814	Major facilitator Superfamily
D7006_14975	COG0513	Belongs to the DEAD box helicase family
D7006_15000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D7006_15020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D7006_15025	COG3668	Plasmid stabilization system
D7006_15035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D7006_15050	COG0203	ribosomal protein L17
D7006_15055	COG0202	RNA polymerase activity
D7006_15060	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D7006_15065	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D7006_15075	COG0563	adenylate kinase activity
D7006_15080	COG0201	protein transport
D7006_15085	COG0200	Binds to the 23S rRNA
D7006_15090	COG1841	ribosomal large subunit assembly
D7006_15095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D7006_15100	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D7006_15105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D7006_15110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D7006_15115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D7006_15120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D7006_15125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D7006_15130	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D7006_15135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D7006_15140	COG0255	Belongs to the universal ribosomal protein uL29 family
D7006_15145	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D7006_15150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D7006_15155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D7006_15160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D7006_15165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D7006_15170	COG0089	rRNA binding
D7006_15175	COG0088	Forms part of the polypeptide exit tunnel
D7006_15180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D7006_15185	COG0051	transcription antitermination factor activity, RNA binding
D7006_15190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D7006_15195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D7006_15200	COG0049	tRNA binding
D7006_15205	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D7006_15210	COG0039	L-malate dehydrogenase activity
D7006_15225	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D7006_15230	COG1704	LemA family
D7006_15240	COG0114	fumarate hydratase activity
D7006_15255	COG0330	HflC and HflK could
D7006_15260	COG0330	HflC and HflK could
D7006_15275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D7006_15275	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D7006_15290	COG3800	Transcriptional regulator
D7006_15290	COG1396	sequence-specific DNA binding
D7006_15295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D7006_15300	COG4770	biotin carboxylase activity
D7006_15305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D7006_15330	COG0163	prenyltransferase activity
D7006_15340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_15355	COG1846	Transcriptional regulator
D7006_15365	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D7006_15370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_15380	COG0604	alcohol dehydrogenase
D7006_15395	COG0318	PFAM AMP-dependent synthetase and ligase
D7006_15410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D7006_15420	COG0859	PFAM glycosyl transferase family 9
D7006_15450	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D7006_15470	COG0308	aminopeptidase N
D7006_15475	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D7006_15485	COG0745	RESPONSE REGULATOR receiver
D7006_15490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7006_15580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D7006_15610	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D7006_15625	COG0302	gtp cyclohydrolase
D7006_15630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D7006_15640	COG1752	Esterase of the alpha-beta hydrolase superfamily
D7006_15645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D7006_15665	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D7006_15680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7006_15685	COG1376	ErfK ybiS ycfS ynhG family protein
D7006_15690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D7006_15715	COG0778	Nitroreductase
D7006_15720	COG4974	Belongs to the 'phage' integrase family
D7006_15735	COG1595	DNA-templated transcription, initiation
D7006_15750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D7006_15755	COG5265	(ABC) transporter
D7006_15765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D7006_15790	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D7006_15795	COG2814	Major facilitator Superfamily
D7006_15810	COG0438	transferase activity, transferring glycosyl groups
D7006_15810	COG1216	Glycosyl transferase, family 2
D7006_15820	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D7006_15830	COG0546	phosphoglycolate phosphatase activity
D7006_15845	COG3685	Protein conserved in bacteria
D7006_15865	COG1376	ErfK ybiS ycfS ynhG family protein
D7006_15870	COG1278	Cold shock
D7006_15875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D7006_15880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_15905	COG0587	DNA-directed DNA polymerase activity
D7006_15910	COG0726	polysaccharide deacetylase
D7006_15915	COG0235	Class ii aldolase
D7006_15920	COG2084	Dehydrogenase
D7006_15930	COG2066	Belongs to the glutaminase family
D7006_15930	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D7006_15955	COG2197	response regulator
D7006_15970	COG4993	Dehydrogenase
D7006_15975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7006_15990	COG0714	Associated with various cellular activities
D7006_16035	COG1012	belongs to the aldehyde dehydrogenase family
D7006_16040	COG1802	Transcriptional regulator
D7006_16050	COG1172	Belongs to the binding-protein-dependent transport system permease family
D7006_16075	COG0667	Aldo Keto reductase
D7006_16085	COG1024	Enoyl-CoA hydratase
D7006_16095	COG0583	DNA-binding transcription factor activity
D7006_16125	COG0754	glutathionylspermidine amidase activity
D7006_16135	COG1968	undecaprenyl-diphosphatase activity
D7006_16140	COG0330	HflC and HflK could
D7006_16145	COG0330	HflC and HflK could
D7006_16150	COG0861	Integral membrane protein TerC family
D7006_16160	COG4139	cobalamin transport
D7006_16200	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D7006_16205	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D7006_16210	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D7006_16215	COG2205	protein histidine kinase activity
D7006_16220	COG0745	RESPONSE REGULATOR receiver
D7006_16255	COG4944	Protein of unknown function (DUF1109)
D7006_16275	COG0559	Belongs to the binding-protein-dependent transport system permease family
D7006_16285	COG0411	ABC transporter
D7006_16300	COG0583	DNA-binding transcription factor activity
D7006_16305	COG0154	amidase activity
D7006_16320	COG1414	Transcriptional regulator
D7006_16340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_16345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D7006_16350	COG1116	anion transmembrane transporter activity
D7006_16375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D7006_16380	COG2205	protein histidine kinase activity
D7006_16380	COG2202	Pas domain
D7006_16395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D7006_16410	COG1309	transcriptional regulator
D7006_16430	COG1309	transcriptional regulator
D7006_16435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D7006_16440	COG2011	ABC-type metal ion transport system permease component
D7006_16445	COG1464	Belongs to the NlpA lipoprotein family
D7006_16450	COG4106	trans-aconitate 2-methyltransferase activity
D7006_16455	COG0174	glutamine synthetase
D7006_16485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D7006_16485	COG0446	pyridine nucleotide-disulphide oxidoreductase
D7006_16500	COG0714	Associated with various cellular activities
D7006_16515	COG2304	oxidoreductase activity
D7006_16530	COG0583	DNA-binding transcription factor activity
D7006_16545	COG1176	ABC-type spermidine putrescine transport system, permease component I
D7006_16555	COG3842	ATPase activity
D7006_16585	COG2814	Major facilitator Superfamily
D7006_16590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D7006_16595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_16600	COG1116	anion transmembrane transporter activity
D7006_16605	COG4191	Histidine kinase
D7006_16615	COG3246	L-lysine catabolic process to acetate
D7006_16620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D7006_16630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D7006_16695	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D7006_16710	COG1278	Cold shock
D7006_16730	COG2223	nitrite transmembrane transporter activity
D7006_16745	COG0583	DNA-binding transcription factor activity
D7006_16755	COG1012	belongs to the aldehyde dehydrogenase family
D7006_16760	COG1802	Transcriptional regulator
D7006_16765	COG0179	Fumarylacetoacetate (FAA) hydrolase
D7006_16780	COG2271	Major facilitator Superfamily
D7006_16785	COG1012	belongs to the aldehyde dehydrogenase family
D7006_16790	COG2271	Major facilitator Superfamily
D7006_16795	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_16825	COG2814	Major facilitator Superfamily
D7006_16835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D7006_16840	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D7006_16850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D7006_16860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D7006_16865	COG2084	Dehydrogenase
D7006_16870	COG3958	Transketolase
D7006_16875	COG3959	Transketolase, thiamine diphosphate binding domain
D7006_16880	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_16885	COG0583	DNA-binding transcription factor activity
D7006_16895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D7006_16930	COG1960	acyl-CoA dehydrogenase activity
D7006_16935	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_16940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7006_16945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D7006_16970	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D7006_16975	COG3246	L-lysine catabolic process to acetate
D7006_16995	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_17000	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7006_17005	COG3604	Transcriptional regulator
D7006_17020	COG0604	alcohol dehydrogenase
D7006_17025	COG1960	acyl-CoA dehydrogenase activity
D7006_17030	COG1846	Transcriptional regulator
D7006_17040	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D7006_17055	COG1024	Enoyl-CoA hydratase
D7006_17055	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7006_17070	COG2030	dehydratase
D7006_17080	COG1902	pentaerythritol trinitrate reductase activity
D7006_17085	COG0028	Belongs to the TPP enzyme family
D7006_17090	COG0492	ferredoxin-NADP+ reductase activity
D7006_17105	COG3971	2-oxopent-4-enoate hydratase activity
D7006_17115	COG2814	Major facilitator Superfamily
D7006_17120	COG0583	DNA-binding transcription factor activity
D7006_17125	COG0477	Major facilitator Superfamily
D7006_17135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D7006_17140	COG0179	Fumarylacetoacetate (FAA) hydrolase
D7006_17145	COG1414	Transcriptional regulator
D7006_17155	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_17170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_17195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_17215	COG1393	Belongs to the ArsC family
D7006_17220	COG0798	PFAM Bile acid sodium symporter
D7006_17225	COG2271	Major facilitator Superfamily
D7006_17245	COG1304	FMN binding
D7006_17260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D7006_17265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_17270	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D7006_17280	COG4948	Mandelate Racemase Muconate Lactonizing
D7006_17325	COG4974	Belongs to the 'phage' integrase family
D7006_17370	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_17375	COG5564	TIM-barrel signal transduction protein
D7006_17385	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D7006_17390	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D7006_17400	COG5441	Belongs to the UPF0261 family
D7006_17405	COG0583	DNA-binding transcription factor activity
D7006_17415	COG2948	multi-organism process
D7006_17425	COG3701	Conjugal transfer protein
D7006_17445	COG3451	type IV secretory pathway VirB4
D7006_17460	COG4962	Type ii secretion system protein e
D7006_17475	COG1204	response to ionizing radiation
D7006_17530	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D7006_17535	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D7006_17580	COG1192	Involved in chromosome partitioning
D7006_17610	COG1476	TRANSCRIPTIONal
D7006_17615	COG5489	Protein of unknown function (DUF736)
D7006_17640	COG1475	DNA binding
D7006_17655	COG4221	oxidoreductase activity
D7006_17665	COG4221	oxidoreductase activity
D7006_17685	COG0163	prenyltransferase activity
D7006_17700	COG1802	Transcriptional regulator
D7006_17710	COG0318	PFAM AMP-dependent synthetase and ligase
D7006_17715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D7006_17730	COG1305	Transglutaminase-like
D7006_17735	COG2307	Protein conserved in bacteria
D7006_17735	COG2308	Evidence 4 Homologs of previously reported genes of
D7006_17755	COG0653	protein targeting
D7006_17770	COG3034	peptidoglycan biosynthetic process
D7006_17775	COG0825	malonyl-CoA metabolic process
D7006_17790	COG1872	DUF167
D7006_17800	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_17805	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D7006_17820	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D7006_17825	COG2721	sulfolactate sulfo-lyase activity
D7006_17835	COG1904	glucuronate isomerase
D7006_17840	COG0246	Mannitol dehydrogenase
D7006_17850	COG0395	ABC-type sugar transport system, permease component
D7006_17865	COG3842	ATPase activity
D7006_17870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D7006_17895	COG0574	Belongs to the PEP-utilizing enzyme family
D7006_17895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D7006_17905	COG0179	Fumarylacetoacetate (FAA) hydrolase
D7006_17910	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D7006_17915	COG0045	succinate-CoA ligase (ADP-forming) activity
D7006_17925	COG4191	Histidine kinase
D7006_17930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7006_17940	COG1802	Transcriptional regulator
D7006_17960	COG1414	Transcriptional regulator
D7006_17965	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D7006_17970	COG1238	metal cluster binding
D7006_17980	COG0067	glutamate synthase
D7006_17980	COG0069	glutamate synthase activity
D7006_17980	COG0070	glutamate synthase
D7006_17990	COG3246	L-lysine catabolic process to acetate
D7006_17995	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7006_18000	COG1129	ABC transporter
D7006_18020	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_18055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D7006_18060	COG0564	pseudouridine synthase activity
D7006_18070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D7006_18080	COG1196	nuclear chromosome segregation
D7006_18090	COG0356	it plays a direct role in the translocation of protons across the membrane
D7006_18100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D7006_18105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D7006_18135	COG2030	dehydratase
D7006_18145	COG3047	cAMP biosynthetic process
D7006_18160	COG1053	succinate dehydrogenase
D7006_18215	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D7006_18220	COG2942	2-epimerase
D7006_18230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D7006_18265	COG1309	transcriptional regulator
D7006_18270	COG1597	lipid kinase activity
D7006_18275	COG1253	flavin adenine dinucleotide binding
D7006_18285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7006_18290	COG0174	glutamine synthetase
D7006_18300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D7006_18315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D7006_18320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D7006_18325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D7006_18330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7006_18330	COG0072	phenylalanine-tRNA ligase activity
D7006_18335	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D7006_18340	COG0594	ribonuclease P activity
D7006_18345	COG0706	membrane insertase activity
D7006_18395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D7006_18400	COG4208	sulfate ABC transporter
D7006_18415	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D7006_18420	COG0697	spore germination
D7006_18425	COG2835	tetraacyldisaccharide 4'-kinase activity
D7006_18430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7006_18430	COG2022	thiamine diphosphate biosynthetic process
D7006_18440	COG2022	thiamine diphosphate biosynthetic process
D7006_18445	COG0352	thiamine-phosphate diphosphorylase activity
D7006_18460	COG0539	negative regulation of cytoplasmic translation
D7006_18500	COG1072	(Pantothenic acid kinase))
D7006_18505	COG0140	phosphoribosyl-ATP diphosphatase activity
D7006_18510	COG0107	imidazoleglycerol-phosphate synthase activity
D7006_18515	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D7006_18520	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D7006_18530	COG0131	Imidazoleglycerol-phosphate dehydratase
D7006_18535	COG2267	carboxylic ester hydrolase activity
D7006_18540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D7006_18545	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D7006_18550	COG2204	response regulator
D7006_18565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D7006_18575	COG0006	proline dipeptidase activity
D7006_18640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D7006_18650	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D7006_18655	COG0384	phenazine biosynthesis protein PhzF
D7006_18660	COG1902	pentaerythritol trinitrate reductase activity
D7006_18685	COG1024	Enoyl-CoA hydratase
D7006_18695	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D7006_18705	COG0175	sulfate reduction
D7006_18710	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D7006_18720	COG4208	sulfate ABC transporter
D7006_18725	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D7006_18740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D7006_18755	COG0183	Belongs to the thiolase family
D7006_18765	COG0457	Tetratricopeptide repeat
D7006_18765	COG3118	belongs to the thioredoxin family
D7006_18770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D7006_18775	COG1742	UPF0060 membrane protein
D7006_18790	COG1309	transcriptional regulator
D7006_18815	COG0142	geranyltranstransferase activity
D7006_18855	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
D7006_18865	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D7006_18890	COG2030	dehydratase
D7006_18890	COG1012	belongs to the aldehyde dehydrogenase family
D7006_18895	COG1024	Enoyl-CoA hydratase
D7006_18895	COG1250	3-hydroxyacyl-CoA dehydrogenase
D7006_18910	COG1024	Enoyl-CoA hydratase
D7006_18915	COG2050	protein possibly involved in aromatic compounds catabolism
D7006_18930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D7006_18935	COG2151	metal-sulfur cluster biosynthetic enzyme
D7006_18940	COG3396	Phenylacetate-CoA oxygenase
D7006_18945	COG3460	Phenylacetate-CoA oxygenase
D7006_18950	COG3396	Phenylacetate-CoA oxygenase
D7006_18955	COG3327	negative regulation of DNA-templated transcription, initiation
D7006_18970	COG0559	Belongs to the binding-protein-dependent transport system permease family
D7006_18990	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D7006_18995	COG4988	ABC transporter
D7006_19030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D7006_19055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7006_19060	COG1522	sequence-specific DNA binding
D7006_19085	COG0366	Alpha amylase catalytic
D7006_19095	COG1741	Belongs to the pirin family
D7006_19110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D7006_19115	COG0791	NLP P60 protein
D7006_19120	COG4251	negative regulation of phosphorylation
D7006_19120	COG5001	Diguanylate cyclase
D7006_19120	COG2203	Gaf domain
D7006_19120	COG3706	GGDEF domain
D7006_19125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D7006_19165	COG0629	single-stranded DNA binding
D7006_19185	COG3750	Belongs to the UPF0335 family
D7006_19435	COG2963	transposase activity
D7006_19440	COG3436	PFAM IS66 Orf2 family protein
D7006_19510	COG0582	viral genome integration into host DNA
D7006_19515	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D7006_19530	COG0596	Alpha beta hydrolase
D7006_19535	COG1414	Transcriptional regulator
D7006_19545	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D7006_19550	COG0183	Belongs to the thiolase family
D7006_19570	COG1172	Belongs to the binding-protein-dependent transport system permease family
D7006_19575	COG1172	Belongs to the binding-protein-dependent transport system permease family
D7006_19580	COG1129	ABC transporter
D7006_19585	COG0277	FAD linked oxidase domain protein
D7006_19590	COG3485	protocatechuate 3,4-dioxygenase
D7006_19600	COG0402	S-adenosylhomocysteine deaminase activity
D7006_19625	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7006_19630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_19655	COG2186	Transcriptional regulator
D7006_19670	COG1024	Enoyl-CoA hydratase
D7006_19675	COG5001	Diguanylate cyclase
D7006_19675	COG3300	MHYT domain
D7006_19690	COG0366	Alpha amylase catalytic
D7006_19695	COG0366	Alpha amylase catalytic
D7006_19700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D7006_19710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D7006_19730	COG0431	NADPH-dependent FMN reductase
D7006_19760	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D7006_19780	COG3258	Cytochrome c
D7006_19785	COG2010	Cytochrome c
D7006_19795	COG0785	Cytochrome C biogenesis protein
D7006_19825	COG4232	protein-disulfide reductase activity
D7006_19835	COG1376	ErfK ybiS ycfS ynhG family protein
D7006_19835	COG1388	LysM domain
D7006_19865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7006_19870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D7006_19880	COG3527	Alpha-acetolactate decarboxylase
D7006_19910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D7006_19915	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_19935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D7006_19940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_19945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_19950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D7006_19970	COG0523	cobalamin synthesis protein
D7006_19995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D7006_20000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D7006_20005	COG1546	Belongs to the CinA family
D7006_20005	COG1058	Belongs to the CinA family
D7006_20010	COG0523	cobalamin synthesis protein
D7006_20025	COG1012	belongs to the aldehyde dehydrogenase family
D7006_20030	COG0402	S-adenosylhomocysteine deaminase activity
D7006_20045	COG0683	leucine binding
D7006_20085	COG0129	dihydroxy-acid dehydratase activity
D7006_20095	COG1609	Transcriptional regulator
D7006_20100	COG2814	Major facilitator Superfamily
D7006_20110	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D7006_20130	COG1335	isochorismatase
D7006_20200	COG0395	ABC-type sugar transport system, permease component
D7006_20205	COG1175	transmembrane transport
D7006_20215	COG3842	ATPase activity
D7006_20225	COG0277	FAD linked oxidase domain protein
D7006_20230	COG1609	Transcriptional regulator
D7006_20255	COG4191	Histidine kinase
D7006_20255	COG0784	Response regulator, receiver
D7006_20260	COG2205	protein histidine kinase activity
D7006_20265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D7006_20280	COG2171	N-acyltransferase activity
D7006_20295	COG2378	regulation of single-species biofilm formation
D7006_20315	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D7006_20330	COG0494	nUDIX hydrolase
D7006_20335	COG4172	Belongs to the ABC transporter superfamily
D7006_20350	COG4239	(ABC) transporter, permease
D7006_20355	COG4174	ABC transporter (Permease)
D7006_20360	COG4166	transmembrane transport
D7006_20365	COG4166	transmembrane transport
D7006_20370	COG3474	cytochrome
D7006_20375	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D7006_20390	COG2816	NAD+ diphosphatase activity
D7006_20400	COG0527	aspartate kinase activity
D7006_20410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D7006_20415	COG2890	protein-(glutamine-N5) methyltransferase activity
D7006_20425	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
D7006_20430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D7006_20430	COG1116	anion transmembrane transporter activity
D7006_20435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_20440	COG1116	anion transmembrane transporter activity
D7006_20440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D7006_20455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D7006_20470	COG1309	transcriptional regulator
D7006_20475	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D7006_20480	COG3258	Cytochrome c
D7006_20485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D7006_20490	COG0193	aminoacyl-tRNA hydrolase activity
D7006_20495	COG0012	GTP binding
D7006_20515	COG2030	dehydratase
D7006_20525	COG0488	(ABC) transporter
D7006_20540	COG0678	peroxiredoxin activity
D7006_20550	COG1678	Uncharacterized ACR, COG1678
D7006_20555	COG3409	Peptidoglycan-binding domain 1 protein
D7006_20555	COG3773	Cell wall hydrolase
D7006_20560	COG1703	isobutyryl-CoA mutase activity
D7006_20575	COG0473	3-isopropylmalate dehydrogenase activity
D7006_20590	COG0494	nUDIX hydrolase
D7006_20595	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D7006_20605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D7006_20615	COG3842	ATPase activity
D7006_20620	COG1177	transmembrane transport
D7006_20625	COG4149	molybdate abc transporter
D7006_20640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D7006_20645	COG2368	4-hydroxyphenylacetate
D7006_20650	COG0583	DNA-binding transcription factor activity
D7006_20660	COG3795	YCII-related domain
D7006_20665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D7006_20690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7006_20695	COG0728	peptidoglycan biosynthetic process
D7006_20700	COG0328	RNA-DNA hybrid ribonuclease activity
D7006_20705	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D7006_20710	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D7006_20720	COG0589	response to stress
D7006_20745	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_20750	COG0314	molybdopterin synthase activity
D7006_20760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D7006_20765	COG0322	excinuclease ABC activity
D7006_20770	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D7006_20775	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D7006_20780	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D7006_20785	COG0673	inositol 2-dehydrogenase activity
D7006_20805	COG2205	protein histidine kinase activity
D7006_20810	COG0745	RESPONSE REGULATOR receiver
D7006_20820	COG3411	Ferredoxin
D7006_20825	COG4150	thiosulfate binding
D7006_20830	COG0667	Aldo Keto reductase
D7006_20840	COG0105	UTP biosynthetic process
D7006_20845	COG0861	Integral membrane protein TerC family
D7006_20850	COG0861	Integral membrane protein TerC family
D7006_20855	COG0243	molybdopterin cofactor binding
D7006_20860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D7006_20865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D7006_20870	COG0583	DNA-binding transcription factor activity
D7006_20875	COG0753	catalase activity
D7006_20880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D7006_20930	COG0552	protein localization to endoplasmic reticulum
D7006_20935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D7006_20940	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D7006_20985	COG4235	cytochrome complex assembly
D7006_20990	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D7006_20995	COG1138	Cytochrome C-type biogenesis protein
D7006_21000	COG3088	subunit of a heme lyase
D7006_21005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D7006_21025	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D7006_21045	COG1960	acyl-CoA dehydrogenase activity
D7006_21055	COG3152	Membrane
D7006_21060	COG2267	carboxylic ester hydrolase activity
D7006_21070	COG2226	methyltransferase
D7006_21075	COG0482	sulfurtransferase activity
D7006_21080	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D7006_21090	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D7006_21095	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D7006_21100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D7006_21110	COG0583	DNA-binding transcription factor activity
D7006_21115	COG2233	PERMEase
D7006_21120	COG2351	hydroxyisourate hydrolase activity
D7006_21125	COG3648	Uricase
D7006_21125	COG3195	allantoin biosynthetic process
D7006_21140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D7006_21145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D7006_21160	COG4651	solute:proton antiporter activity
D7006_21160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D7006_21170	COG1121	(ABC) transporter
D7006_21175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D7006_21180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D7006_21195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D7006_21220	COG1376	ErfK ybiS ycfS ynhG family protein
D7006_21225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D7006_21230	COG5002	protein histidine kinase activity
D7006_21230	COG2205	protein histidine kinase activity
D7006_21230	COG0784	Response regulator, receiver
D7006_21240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D7006_21245	COG2514	catechol 2,3-dioxygenase activity
D7006_21255	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D7006_21255	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D7006_21270	COG0604	alcohol dehydrogenase
D7006_21275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D7006_21280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D7006_21290	COG1201	RNA secondary structure unwinding
D7006_21300	COG3038	cytochrome b561
D7006_21305	COG0066	3-isopropylmalate dehydratase activity
D7006_21325	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D7006_21330	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D7006_21345	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D7006_21350	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D7006_21360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7006_21375	COG2983	Belongs to the UPF0260 family
D7006_21390	COG3706	GGDEF domain
D7006_21415	COG0305	Participates in initiation and elongation during chromosome replication
D7006_21420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D7006_21440	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D7006_21450	COG0300	oxidoreductase activity
D7006_21465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D7006_21470	COG0509	glycine decarboxylation via glycine cleavage system
D7006_21480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D7006_21485	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D7006_21490	COG0494	nUDIX hydrolase
D7006_21500	COG1999	signal sequence binding
D7006_21530	COG0776	regulation of translation
D7006_21535	COG0616	signal peptide processing
D7006_21540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D7006_21545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D7006_21550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D7006_21555	COG1420	regulation of RNA biosynthetic process
D7006_21560	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D7006_21570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D7006_21575	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D7006_21580	COG1366	Belongs to the anti-sigma-factor antagonist family
D7006_21585	COG1283	sodium-dependent phosphate transmembrane transporter activity
D7006_21630	COG2208	phosphoserine phosphatase activity
D7006_21630	COG2770	Histidine kinase
D7006_21640	COG0277	FAD linked oxidase domain protein
D7006_21645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D7006_21655	COG0335	large ribosomal subunit rRNA binding
D7006_21665	COG2201	protein-glutamate methylesterase activity
D7006_21670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D7006_21670	COG1116	anion transmembrane transporter activity
D7006_21675	COG1160	GTP binding
D7006_21690	COG3279	Response regulator of the LytR AlgR family
D7006_21700	COG1671	Belongs to the UPF0178 family
D7006_21730	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D7006_21740	COG1496	oxidoreductase activity
D7006_21755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D7006_21765	COG0671	phosphoesterase, PA-phosphatase related
D7006_21775	COG1846	Transcriptional regulator
D7006_21780	COG0745	RESPONSE REGULATOR receiver
D7006_21790	COG0617	tRNA 3'-terminal CCA addition
D7006_21795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7006_21820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D7006_21825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7006_21830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D7006_21850	COG0517	IMP dehydrogenase activity
D7006_21850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D7006_21855	COG0450	alkyl hydroperoxide reductase
D7006_21865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D7006_21875	COG3960	tartronate-semialdehyde synthase activity
D7006_21880	COG3622	Belongs to the hyi family
D7006_21885	COG2084	Dehydrogenase
D7006_21890	COG0469	pyruvate kinase activity
D7006_21895	COG2954	triphosphatase activity
D7006_21920	COG1609	Transcriptional regulator
D7006_21935	COG3246	L-lysine catabolic process to acetate
D7006_21940	COG4221	oxidoreductase activity
D7006_21940	COG3321	synthase
D7006_21940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D7006_21940	COG0604	alcohol dehydrogenase
D7006_21950	COG1301	dicarboxylic acid transport
D7006_21955	COG1648	precorrin-2 dehydrogenase activity
D7006_21955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D7006_21960	COG0251	oxidation-reduction process
D7006_21965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D7006_21965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D7006_21970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D7006_21975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_21980	COG1116	anion transmembrane transporter activity
D7006_21990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D7006_21995	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D7006_22005	COG0243	molybdopterin cofactor binding
D7006_22010	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D7006_22025	COG3162	membrane
D7006_22030	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D7006_22045	COG5002	protein histidine kinase activity
D7006_22050	COG0745	RESPONSE REGULATOR receiver
D7006_22055	COG2176	DNA-directed DNA polymerase activity
D7006_22055	COG5002	protein histidine kinase activity
D7006_22060	COG2267	carboxylic ester hydrolase activity
D7006_22080	COG0163	prenyltransferase activity
D7006_22085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D7006_22100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_22130	COG1024	Enoyl-CoA hydratase
D7006_22140	COG0028	Belongs to the TPP enzyme family
D7006_22145	COG1012	belongs to the aldehyde dehydrogenase family
D7006_22160	COG0583	DNA-binding transcription factor activity
D7006_22165	COG2249	NAD(P)H dehydrogenase (quinone) activity
D7006_22180	COG1335	isochorismatase
D7006_22195	COG1858	cytochrome C peroxidase
D7006_22205	COG1294	oxidase, subunit
D7006_22235	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D7006_22245	COG0473	3-isopropylmalate dehydrogenase activity
D7006_22255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D7006_22265	COG4208	sulfate ABC transporter
D7006_22270	COG1176	ABC-type spermidine putrescine transport system, permease component I
D7006_22280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7006_22295	COG0583	DNA-binding transcription factor activity
D7006_22400	COG1024	Enoyl-CoA hydratase
D7006_22405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D7006_22420	COG0242	peptide deformylase activity
D7006_22425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D7006_22435	COG0101	tRNA pseudouridine synthase activity
D7006_22450	COG1074	ATP-dependent DNA helicase activity
D7006_22455	COG2887	Belongs to the helicase family. UvrD subfamily
D7006_22460	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D7006_22465	COG3178	'Phosphotransferase
D7006_22470	COG2205	protein histidine kinase activity
D7006_22480	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D7006_22485	COG1695	Transcriptional regulator
D7006_22495	COG0651	ATP synthesis coupled electron transport
D7006_22500	COG0650	Formate hydrogenlyase subunit 4
D7006_22510	COG0651	ATP synthesis coupled electron transport
D7006_22515	COG0649	NAD binding
D7006_22520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D7006_22525	COG1012	belongs to the aldehyde dehydrogenase family
D7006_22530	COG3284	Transcriptional regulator
D7006_22540	COG1609	Transcriptional regulator
D7006_22560	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D7006_22585	COG0583	DNA-binding transcription factor activity
D7006_22590	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D7006_22595	COG0459	protein refolding
D7006_22600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D7006_22610	COG2066	Belongs to the glutaminase family
D7006_22615	COG4774	siderophore transport
D7006_22625	COG0481	GTPase activity
D7006_22645	COG0181	hydroxymethylbilane synthase activity
D7006_22650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D7006_22655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D7006_22675	COG2264	protein methyltransferase activity
D7006_22705	COG0477	Major facilitator Superfamily
D7006_22710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7006_22715	COG1609	Transcriptional regulator
D7006_22725	COG0435	Glutathione S-transferase
D7006_22740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7006_22745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D7006_22755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D7006_22770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D7006_22780	COG2217	Heavy metal translocating P-type atpase
D7006_22805	COG0443	Heat shock 70 kDa protein
D7006_22810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D7006_22825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D7006_22855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7006_22860	COG0577	efflux transmembrane transporter activity
D7006_22860	COG1136	(ABC) transporter
D7006_22875	COG3128	pkhd-type hydroxylase
D7006_22885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D7006_22890	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D7006_22895	COG2080	2 iron, 2 sulfur cluster binding
D7006_22915	COG1304	FMN binding
D7006_22920	COG2186	Transcriptional regulator
D7006_22935	COG0583	DNA-binding transcription factor activity
D7006_22965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7006_22970	COG1120	ATPase activity
D7006_22975	COG4774	siderophore transport
D7006_22980	COG1960	acyl-CoA dehydrogenase activity
D7006_22990	COG1024	Enoyl-CoA hydratase
D7006_22995	COG0583	DNA-binding transcription factor activity
D7006_23015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D7006_23040	COG2267	carboxylic ester hydrolase activity
D7006_23045	COG0251	oxidation-reduction process
D7006_23050	COG0583	DNA-binding transcription factor activity
D7006_23065	COG3386	PFAM SMP-30 Gluconolaconase
D7006_23075	COG4214	carbohydrate transport
D7006_23090	COG1137	ATPase activity
D7006_23100	COG0640	Transcriptional regulator
D7006_23135	COG2301	Belongs to the HpcH HpaI aldolase family
D7006_23140	COG2030	dehydratase
D7006_23165	COG1414	Transcriptional regulator
D7006_23215	COG3293	Transposase
D7006_23225	COG3383	formate dehydrogenase (NAD+) activity
D7006_23270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D7006_23310	COG1522	sequence-specific DNA binding
D7006_23320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7006_23325	COG1129	ABC transporter
D7006_23325	COG0842	Transport permease protein
D7006_23330	COG0842	Transport permease protein
D7006_23335	COG1959	2 iron, 2 sulfur cluster binding
D7006_23340	COG2917	probably involved in intracellular septation
D7006_23345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7006_23350	COG0142	geranyltranstransferase activity
D7006_23355	COG0588	phosphoglycerate mutase activity
D7006_23360	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D7006_23370	COG0284	orotidine-5'-phosphate decarboxylase activity
D7006_23380	COG3963	phosphatidate phosphatase activity
D7006_23395	COG0484	heat shock protein binding
D7006_23405	COG0443	Heat shock 70 kDa protein
D7006_23410	COG1335	isochorismatase
D7006_23455	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D7006_23460	COG0792	nuclease activity
D7006_23465	COG0189	ligase activity
D7006_23475	COG2226	methyltransferase
D7006_23480	COG0606	chelatase, subunit chli
D7006_23500	COG0497	DNA recombination
D7006_23505	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D7006_23515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D7006_23520	COG0849	cell division
D7006_23525	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D7006_23530	COG1181	Belongs to the D-alanine--D-alanine ligase family
D7006_23535	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D7006_23540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D7006_23550	COG0657	acetylesterase activity
D7006_23555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7006_23570	COG3395	kinase activity
D7006_23575	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D7006_23610	COG3655	Transcriptional regulator
D7006_23620	COG0702	epimerase
D7006_23660	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D7006_23690	COG0436	Aminotransferase
D7006_23700	COG0747	negative chemotaxis
D7006_23705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D7006_23710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D7006_23720	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D7006_23735	COG0779	Required for maturation of 30S ribosomal subunits
D7006_23750	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D7006_23755	COG1185	polyribonucleotide nucleotidyltransferase activity
D7006_23770	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D7006_23775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D7006_23790	COG0523	cobalamin synthesis protein
D7006_23795	COG1686	Belongs to the peptidase S11 family
D7006_23800	COG1132	(ABC) transporter
D7006_23815	COG1960	acyl-CoA dehydrogenase activity
D7006_23825	COG4191	Histidine kinase
D7006_23825	COG0784	Response regulator, receiver
D7006_23835	COG0784	Response regulator, receiver
D7006_23855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D7006_23860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D7006_23860	COG2813	Specifically methylates the guanine in position
D7006_23880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D7006_23930	COG5002	protein histidine kinase activity
D7006_23940	COG0573	inorganic phosphate transmembrane transporter activity
D7006_23950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D7006_23955	COG0704	Plays a role in the regulation of phosphate uptake
D7006_23960	COG0745	RESPONSE REGULATOR receiver
D7006_23975	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_23980	COG0697	spore germination
D7006_24020	COG0739	heme binding
D7006_24055	COG0542	response to heat
D7006_24080	COG2204	response regulator
D7006_24085	COG4191	Histidine kinase
D7006_24090	COG1301	dicarboxylic acid transport
D7006_24100	COG0840	transmembrane signaling receptor activity
D7006_24120	COG0247	lactate metabolic process
D7006_24125	COG1139	Iron-sulfur cluster binding protein
D7006_24130	COG1556	Lactate utilization protein
D7006_24150	COG0583	DNA-binding transcription factor activity
D7006_24155	COG0277	FAD linked oxidase domain protein
D7006_24165	COG0247	lactate metabolic process
D7006_24170	COG0352	thiamine-phosphate diphosphorylase activity
D7006_24175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D7006_24180	COG0702	epimerase
D7006_24190	COG0189	ligase activity
D7006_24215	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
D7006_24220	COG1229	Formylmethanofuran dehydrogenase subunit A
D7006_24240	COG0535	radical SAM domain protein
D7006_24245	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
D7006_24250	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
D7006_24270	COG2205	protein histidine kinase activity
D7006_24275	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D7006_24285	COG1968	undecaprenyl-diphosphatase activity
D7006_24295	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D7006_24300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D7006_24305	COG1702	phosphate starvation-inducible protein PhoH
D7006_24310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D7006_24315	COG1253	flavin adenine dinucleotide binding
D7006_24320	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D7006_24325	COG1396	sequence-specific DNA binding
D7006_24330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D7006_24335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D7006_24365	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D7006_24370	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D7006_24375	COG1981	membrane
D7006_24380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D7006_24385	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D7006_24390	COG0424	maF-like protein
D7006_24395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D7006_24400	COG0237	dephospho-CoA kinase activity
D7006_24405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D7006_24410	COG1331	Highly conserved protein containing a thioredoxin domain
D7006_24415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D7006_24420	COG0445	tRNA wobble uridine modification
D7006_24425	COG0357	Ribosomal RNA small subunit methyltransferase G
D7006_24440	COG4957	zinc ion binding
D7006_24445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D7006_24450	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D7006_24455	COG1674	ftsk spoiiie
D7006_24460	COG0436	Aminotransferase
D7006_24465	COG0196	riboflavin kinase activity
D7006_24475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D7006_24485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D7006_24490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D7006_24495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D7006_24510	COG0275	rRNA processing
D7006_24515	COG2001	Belongs to the MraZ family
D7006_24520	COG0330	HflC and HflK could
D7006_24525	COG1585	Membrane protein implicated in regulation of membrane protease activity
D7006_24535	COG0564	pseudouridine synthase activity
D7006_24540	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D7006_24555	COG1028	Short-chain dehydrogenase reductase Sdr
D7006_24565	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D7006_24585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D7006_24590	COG1132	(ABC) transporter
D7006_24600	COG5001	Diguanylate cyclase
D7006_24605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D7006_24605	COG0045	succinate-CoA ligase (ADP-forming) activity
D7006_24605	COG1042	CoA-binding domain protein
D7006_24610	COG4566	intracellular signal transduction
D7006_24615	COG4566	intracellular signal transduction
D7006_24620	COG4191	Histidine kinase
D7006_24625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D7006_24630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D7006_24670	COG1024	Enoyl-CoA hydratase
D7006_24675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D7006_24680	COG1309	transcriptional regulator
D7006_24685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D7006_24695	COG1022	Amp-dependent synthetase and ligase
D7006_24775	COG3023	N-Acetylmuramoyl-L-alanine amidase
D7006_24785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D7006_24790	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
D7006_24795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D7006_24830	COG4181	ATPase activity
D7006_24850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D7006_24865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D7006_24895	COG0019	diaminopimelate decarboxylase activity
D7006_24905	COG0165	Argininosuccinate lyase
D7006_24910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7006_24915	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D7006_24925	COG1215	transferase activity, transferring glycosyl groups
D7006_24940	COG1846	Transcriptional regulator
D7006_24945	COG0138	bifunctional purine biosynthesis protein purh
D7006_24950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D7006_24965	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D7006_24970	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D7006_24970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D7006_24980	COG0501	Belongs to the peptidase M48B family
D7006_24990	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
D7006_25020	COG3842	ATPase activity
D7006_25035	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D7006_25035	COG0037	tRNA processing
D7006_25040	COG2884	Cell division ATP-binding protein ftsE
D7006_25065	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D7006_25075	COG3454	Phosphonate metabolism
D7006_25085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D7006_25095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP