locus-tag	class	description
KP728_00010	COG0745	RESPONSE REGULATOR receiver
KP728_00020	COG0835	chemotaxis
KP728_00030	COG1360	Flagellar Motor Protein
KP728_00035	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KP728_00085	COG0643	Histidine kinase
KP728_00085	COG0784	Response regulator, receiver
KP728_00085	COG2198	Histidine kinase
KP728_00135	COG3300	MHYT domain
KP728_00135	COG5001	Diguanylate cyclase
KP728_00140	COG1684	flagellar biosynthetic protein fliR
KP728_00155	COG3190	flagellar
KP728_00205	COG1677	Flagellar hook-basal body complex protein FliE
KP728_00235	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_00245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KP728_00265	COG2201	protein-glutamate methylesterase activity
KP728_00295	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KP728_00300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KP728_00315	COG1705	Flagellar rod assembly protein muramidase FlgJ
KP728_00315	COG3951	Flagellar rod assembly protein muramidase FlgJ
KP728_00320	COG1706	bacterial-type flagellum-dependent cell motility
KP728_00325	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KP728_00335	COG4787	bacterial-type flagellum-dependent cell motility
KP728_00345	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KP728_00350	COG1558	bacterial-type flagellum-dependent cell motility
KP728_00355	COG1815	bacterial-type flagellum-dependent cell motility
KP728_00360	COG0835	chemotaxis
KP728_00360	COG0784	Response regulator, receiver
KP728_00365	COG3039	Transposase
KP728_00385	COG4191	Histidine kinase
KP728_00420	COG0482	sulfurtransferase activity
KP728_00435	COG0542	response to heat
KP728_00445	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KP728_00455	COG0492	ferredoxin-NADP+ reductase activity
KP728_00460	COG1674	ftsk spoiiie
KP728_00480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KP728_00485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KP728_00490	COG0183	Belongs to the thiolase family
KP728_00495	COG1024	Enoyl-CoA hydratase
KP728_00495	COG1250	3-hydroxyacyl-CoA dehydrogenase
KP728_00510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KP728_00520	COG1426	Protein conserved in bacteria
KP728_00530	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KP728_00535	COG1160	GTP binding
KP728_00540	COG0303	'Molybdopterin
KP728_00545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KP728_00565	COG0708	Exodeoxyribonuclease III
KP728_00575	COG0303	'Molybdopterin
KP728_00580	COG0746	molybdenum cofactor guanylyltransferase activity
KP728_00590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KP728_00590	COG1648	precorrin-2 dehydrogenase activity
KP728_00600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KP728_00605	COG2223	nitrite transmembrane transporter activity
KP728_00610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KP728_00620	COG0243	molybdopterin cofactor binding
KP728_00640	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
KP728_00650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KP728_00660	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KP728_00680	COG5001	Diguanylate cyclase
KP728_00735	COG4191	Histidine kinase
KP728_00735	COG0784	Response regulator, receiver
KP728_00795	COG0840	transmembrane signaling receptor activity
KP728_00825	COG3781	membrane
KP728_00835	COG2197	response regulator
KP728_00850	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_00970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KP728_00975	COG1335	isochorismatase
KP728_00990	COG1566	PFAM secretion protein HlyD family protein
KP728_01005	COG0583	DNA-binding transcription factor activity
KP728_01010	COG1902	pentaerythritol trinitrate reductase activity
KP728_01015	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_01055	COG2154	pterin-4-alpha-carbinolamine dehydratase
KP728_01065	COG0428	transporter
KP728_01075	COG1530	ribonuclease E activity
KP728_01085	COG1054	Belongs to the UPF0176 family
KP728_01105	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KP728_01150	COG2894	cell division
KP728_01185	COG0629	single-stranded DNA binding
KP728_01190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KP728_01195	COG0270	DNA (cytosine-5-)-methyltransferase activity
KP728_01410	COG2003	Belongs to the UPF0758 family
KP728_01445	COG3830	Belongs to the UPF0237 family
KP728_01445	COG0560	Phosphoserine phosphatase
KP728_01455	COG4221	oxidoreductase activity
KP728_01460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KP728_01465	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_01555	COG1074	ATP-dependent DNA helicase activity
KP728_01570	COG3039	Transposase
KP728_01575	COG0583	DNA-binding transcription factor activity
KP728_01580	COG1396	sequence-specific DNA binding
KP728_01625	COG4584	PFAM Integrase catalytic
KP728_01635	COG0582	viral genome integration into host DNA
KP728_01645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KP728_01650	COG0322	excinuclease ABC activity
KP728_01660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KP728_01670	COG1663	tetraacyldisaccharide 4'-kinase activity
KP728_01675	COG1132	(ABC) transporter
KP728_01680	COG0848	biopolymer transport protein
KP728_01685	COG0811	peptide transport
KP728_01700	COG1136	(ABC) transporter
KP728_01705	COG4591	ABC-type transport system involved in lipoprotein release permease component
KP728_01715	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KP728_01720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KP728_01735	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KP728_01760	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KP728_01765	COG0837	glucose binding
KP728_01775	COG0129	dihydroxy-acid dehydratase activity
KP728_01780	COG0800	Aldolase
KP728_01870	COG0582	viral genome integration into host DNA
KP728_01885	COG2205	protein histidine kinase activity
KP728_01885	COG5002	protein histidine kinase activity
KP728_01885	COG0784	Response regulator, receiver
KP728_01890	COG2183	response to ionizing radiation
KP728_01900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KP728_01900	COG0723	plastoquinol--plastocyanin reductase activity
KP728_01915	COG3243	poly(R)-hydroxyalkanoic acid synthase
KP728_01925	COG1183	phosphatidylcholine synthase activity
KP728_01930	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_01955	COG0668	transmembrane transport
KP728_01960	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KP728_01975	COG1914	H( )-stimulated, divalent metal cation uptake system
KP728_02085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KP728_02100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KP728_02115	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KP728_02130	COG0539	negative regulation of cytoplasmic translation
KP728_02135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KP728_02150	COG2957	Belongs to the agmatine deiminase family
KP728_02155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KP728_02180	COG0395	ABC-type sugar transport system, permease component
KP728_02185	COG1175	transmembrane transport
KP728_02190	COG1653	transport
KP728_02205	COG1609	Transcriptional regulator
KP728_02215	COG2350	Protein conserved in bacteria
KP728_02220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KP728_02225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KP728_02230	COG1187	pseudouridine synthase activity
KP728_02250	COG0436	Aminotransferase
KP728_02255	COG4133	protoheme IX ABC transporter activity
KP728_02275	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KP728_02300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KP728_02310	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KP728_02315	COG4988	ABC transporter
KP728_02325	COG1294	oxidase, subunit
KP728_02370	COG0165	Argininosuccinate lyase
KP728_02385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KP728_02390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KP728_02395	COG0137	argininosuccinate synthase activity
KP728_02400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KP728_02410	COG0215	cysteine-tRNA ligase activity
KP728_02415	COG2166	iron-sulfur cluster assembly
KP728_02440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KP728_02455	COG4303	Ethanolamine ammonia lyase large subunit
KP728_02460	COG4302	ethanolamine ammonia-lyase activity
KP728_02510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KP728_02515	COG0402	S-adenosylhomocysteine deaminase activity
KP728_02525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KP728_02535	COG3300	MHYT domain
KP728_02535	COG5001	Diguanylate cyclase
KP728_02550	COG0483	inositol monophosphate 1-phosphatase activity
KP728_02555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KP728_02570	COG0488	(ABC) transporter
KP728_02575	COG0513	Belongs to the DEAD box helicase family
KP728_02580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KP728_02585	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KP728_02595	COG0625	glutathione transferase activity
KP728_02610	COG4681	YaeQ
KP728_02615	COG2081	HI0933 family
KP728_02630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KP728_02635	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_02655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KP728_02660	COG0860	N-Acetylmuramoyl-L-alanine amidase
KP728_02670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KP728_02670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KP728_02675	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KP728_02690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KP728_02720	COG0835	chemotaxis
KP728_02725	COG0840	transmembrane signaling receptor activity
KP728_02730	COG2094	Belongs to the DNA glycosylase MPG family
KP728_02735	COG1201	RNA secondary structure unwinding
KP728_02745	COG2969	positive regulation of protein catabolic process
KP728_02750	COG0625	glutathione transferase activity
KP728_02755	COG2857	Cytochrome c1
KP728_02760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KP728_02765	COG0723	plastoquinol--plastocyanin reductase activity
KP728_02770	COG0741	lytic transglycosylase activity
KP728_02790	COG1702	phosphate starvation-inducible protein PhoH
KP728_02810	COG4535	Mg2 and Co2 transporter CorC
KP728_02825	COG1012	belongs to the aldehyde dehydrogenase family
KP728_02835	COG1177	transmembrane transport
KP728_02840	COG1176	ABC-type spermidine putrescine transport system, permease component I
KP728_02845	COG3842	ATPase activity
KP728_02865	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KP728_02880	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KP728_02885	COG0174	glutamine synthetase
KP728_02890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KP728_02900	COG2703	oxygen carrier activity
KP728_02905	COG0477	Major facilitator Superfamily
KP728_02915	COG0243	molybdopterin cofactor binding
KP728_02925	COG2223	nitrite transmembrane transporter activity
KP728_02930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KP728_02940	COG2733	membrane
KP728_02945	COG0784	Response regulator, receiver
KP728_02945	COG2205	protein histidine kinase activity
KP728_02945	COG5002	protein histidine kinase activity
KP728_02955	COG0477	Major facilitator Superfamily
KP728_02970	COG0300	oxidoreductase activity
KP728_02980	COG1902	pentaerythritol trinitrate reductase activity
KP728_02990	COG0604	alcohol dehydrogenase
KP728_02995	COG2902	Dehydrogenase
KP728_03005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KP728_03010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KP728_03020	COG1609	Transcriptional regulator
KP728_03025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KP728_03025	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KP728_03030	COG1105	Belongs to the carbohydrate kinase PfkB family
KP728_03035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KP728_03035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KP728_03045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KP728_03055	COG1862	Preprotein translocase
KP728_03065	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KP728_03105	COG3291	Pkd domain containing protein
KP728_03115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KP728_03135	COG0742	ribosomal rna small subunit methyltransferase
KP728_03165	COG4206	TonB-dependent receptor
KP728_03240	COG0531	amino acid
KP728_03255	COG0006	proline dipeptidase activity
KP728_03265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KP728_03280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KP728_03285	COG3938	Belongs to the proline racemase family
KP728_03295	COG0552	protein localization to endoplasmic reticulum
KP728_03310	COG4191	Histidine kinase
KP728_03310	COG0784	Response regulator, receiver
KP728_03320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KP728_03340	COG3040	lipid binding
KP728_03350	COG1960	acyl-CoA dehydrogenase activity
KP728_03360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KP728_03380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KP728_03385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KP728_03390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KP728_03415	COG0438	transferase activity, transferring glycosyl groups
KP728_03425	COG0438	transferase activity, transferring glycosyl groups
KP728_03430	COG0438	transferase activity, transferring glycosyl groups
KP728_03480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KP728_03480	COG0072	phenylalanine-tRNA ligase activity
KP728_03485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KP728_03500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KP728_03505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KP728_03520	COG2190	(PTS) system
KP728_03520	COG2211	Major facilitator Superfamily
KP728_03530	COG1082	Xylose isomerase domain protein TIM barrel
KP728_03540	COG0366	Alpha amylase catalytic
KP728_03595	COG3702	type iv secretory pathway
KP728_03615	COG2948	multi-organism process
KP728_03635	COG3505	Type IV secretory pathway VirD4
KP728_03650	COG0556	nucleotide-excision repair
KP728_03680	COG4695	Portal protein
KP728_03750	COG0840	transmembrane signaling receptor activity
KP728_03950	COG1611	Belongs to the LOG family
KP728_03960	COG2095	MarC family integral membrane protein
KP728_03965	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_03970	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KP728_04005	COG1185	polyribonucleotide nucleotidyltransferase activity
KP728_04010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KP728_04015	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KP728_04020	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KP728_04030	COG0195	Participates in both transcription termination and antitermination
KP728_04035	COG0779	Required for maturation of 30S ribosomal subunits
KP728_04045	COG1007	ATP synthesis coupled electron transport
KP728_04065	COG0839	Belongs to the complex I subunit 6 family
KP728_04070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KP728_04075	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KP728_04085	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KP728_04090	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KP728_04100	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KP728_04110	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KP728_04130	COG4221	oxidoreductase activity
KP728_04160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KP728_04165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KP728_04180	COG0133	tryptophan synthase activity
KP728_04195	COG0101	tRNA pseudouridine synthase activity
KP728_04240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KP728_04250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KP728_04260	COG2890	protein-(glutamine-N5) methyltransferase activity
KP728_04270	COG0688	phosphatidylethanolamine metabolic process
KP728_04280	COG0433	COG0433 Predicted ATPase
KP728_04285	COG0494	nUDIX hydrolase
KP728_04300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KP728_04305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KP728_04325	COG2801	Transposase and inactivated derivatives
KP728_04330	COG3002	Belongs to the UPF0753 family
KP728_04355	COG3706	GGDEF domain
KP728_04390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KP728_04405	COG0583	DNA-binding transcription factor activity
KP728_04415	COG0415	Belongs to the DNA photolyase family
KP728_04420	COG0305	Participates in initiation and elongation during chromosome replication
KP728_04430	COG0367	asparagine synthase
KP728_04445	COG1960	acyl-CoA dehydrogenase activity
KP728_04460	COG0084	hydrolase, TatD family'
KP728_04465	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KP728_04485	COG2839	Protein conserved in bacteria
KP728_04495	COG0288	reversible hydration of carbon dioxide
KP728_04525	COG0386	Belongs to the glutathione peroxidase family
KP728_04530	COG0339	signal peptide processing
KP728_04590	COG2814	Major facilitator Superfamily
KP728_04595	COG1566	PFAM secretion protein HlyD family protein
KP728_04635	COG4774	siderophore transport
KP728_04645	COG0367	asparagine synthase
KP728_04655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KP728_04660	COG1393	Belongs to the ArsC family
KP728_04715	COG0052	Belongs to the universal ribosomal protein uS2 family
KP728_04720	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KP728_04730	COG0528	UMP kinase activity
KP728_04735	COG0233	cytoplasmic translational termination
KP728_04745	COG0575	Belongs to the CDS family
KP728_04750	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KP728_04755	COG0750	zinc metalloprotease
KP728_04770	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KP728_04780	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KP728_04785	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KP728_04805	COG1981	membrane
KP728_04820	COG1695	Transcriptional regulator
KP728_04835	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KP728_04855	COG2040	homocysteine
KP728_04860	COG0833	amino acid
KP728_04880	COG0346	lactoylglutathione lyase activity
KP728_04885	COG1131	(ABC) transporter
KP728_04900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KP728_04900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KP728_04910	COG2878	Part of a membrane complex involved in electron transport
KP728_04925	COG1595	DNA-templated transcription, initiation
KP728_04950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KP728_04965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KP728_04970	COG0251	oxidation-reduction process
KP728_04980	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KP728_04980	COG0392	lysyltransferase activity
KP728_05015	COG2814	Major facilitator Superfamily
KP728_05020	COG1902	pentaerythritol trinitrate reductase activity
KP728_05040	COG2824	Alkylphosphonate utilization operon protein PhnA
KP728_05050	COG1047	Peptidyl-prolyl cis-trans
KP728_05095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KP728_05105	COG5487	UPF0391 membrane protein
KP728_05110	COG1451	nucleotide metabolic process
KP728_05130	COG0183	Belongs to the thiolase family
KP728_05160	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KP728_05160	COG1793	dna ligase
KP728_05170	COG1793	dna ligase
KP728_05175	COG1201	RNA secondary structure unwinding
KP728_05185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KP728_05190	COG1278	Cold shock
KP728_05195	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KP728_05200	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KP728_05205	COG1472	Belongs to the glycosyl hydrolase 3 family
KP728_05210	COG3046	protein related to deoxyribodipyrimidine photolyase
KP728_05215	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
KP728_05220	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KP728_05225	COG2954	triphosphatase activity
KP728_05240	COG1381	Involved in DNA repair and RecF pathway recombination
KP728_05245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KP728_05250	COG0571	ribonuclease III activity
KP728_05280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KP728_05295	COG1024	Enoyl-CoA hydratase
KP728_05295	COG1250	3-hydroxyacyl-CoA dehydrogenase
KP728_05305	COG0457	Tetratricopeptide repeat
KP728_05345	COG1960	acyl-CoA dehydrogenase activity
KP728_05355	COG3800	Transcriptional regulator
KP728_05355	COG1396	sequence-specific DNA binding
KP728_05365	COG3867	Arabinogalactan endo-beta-1,4-galactanase
KP728_05370	COG3250	beta-galactosidase activity
KP728_05385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KP728_05395	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KP728_05405	COG0534	Mate efflux family protein
KP728_05415	COG0336	Belongs to the RNA methyltransferase TrmD family
KP728_05435	COG2070	2-Nitropropane dioxygenase
KP728_05440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KP728_05455	COG3534	alpha-L-arabinofuranosidase
KP728_05485	COG4191	Histidine kinase
KP728_05485	COG0784	Response regulator, receiver
KP728_05490	COG3437	response regulator, receiver
KP728_05490	COG3850	Histidine kinase
KP728_05490	COG4999	Histidine kinase
KP728_05490	COG2205	protein histidine kinase activity
KP728_05495	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KP728_05505	COG2205	protein histidine kinase activity
KP728_05510	COG5507	3-demethylubiquinone-9 3-methyltransferase
KP728_05520	COG4771	TonB-dependent receptor
KP728_05550	COG2172	sigma factor antagonist activity
KP728_05555	COG1366	Belongs to the anti-sigma-factor antagonist family
KP728_05560	COG1366	Belongs to the anti-sigma-factor antagonist family
KP728_05565	COG1902	pentaerythritol trinitrate reductase activity
KP728_05575	COG0326	Molecular chaperone. Has ATPase activity
KP728_05580	COG2207	Transcriptional regulator
KP728_05590	COG3152	Membrane
KP728_05605	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KP728_05610	COG1845	cytochrome c oxidase, subunit III
KP728_05615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KP728_05630	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KP728_05635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KP728_05640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KP728_05645	COG0196	riboflavin kinase activity
KP728_05650	COG0728	peptidoglycan biosynthetic process
KP728_05660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KP728_05665	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KP728_05675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KP728_05680	COG0824	Thioesterase
KP728_05690	COG1024	Enoyl-CoA hydratase
KP728_05695	COG1946	Acyl-CoA thioesterase
KP728_05705	COG1595	DNA-templated transcription, initiation
KP728_05715	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KP728_05750	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KP728_05765	COG2197	response regulator
KP728_05770	COG4585	Histidine kinase
KP728_05780	COG0850	regulation of cytokinetic process
KP728_05785	COG2894	cell division
KP728_05790	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KP728_05805	COG5002	protein histidine kinase activity
KP728_05810	COG0745	RESPONSE REGULATOR receiver
KP728_05825	COG2194	sulfuric ester hydrolase activity
KP728_05845	COG2814	Major facilitator Superfamily
KP728_05850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KP728_05850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KP728_05855	COG2272	Belongs to the type-B carboxylesterase lipase family
KP728_05860	COG0656	L-ascorbic acid biosynthetic process
KP728_05865	COG0753	catalase activity
KP728_05870	COG1917	Cupin 2, conserved barrel domain protein
KP728_05870	COG2207	Transcriptional regulator
KP728_05885	COG0823	Involved in the tonB-independent uptake of proteins
KP728_05885	COG1506	peptidase
KP728_05905	COG1297	OPT oligopeptide transporter protein
KP728_05915	COG0587	DNA-directed DNA polymerase activity
KP728_05930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KP728_05975	COG2080	2 iron, 2 sulfur cluster binding
KP728_05980	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KP728_05985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KP728_06010	COG2271	Major facilitator Superfamily
KP728_06025	COG2323	membrane
KP728_06065	COG3537	Alpha-1,2-mannosidase
KP728_06075	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_06085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KP728_06095	COG1309	transcriptional regulator
KP728_06140	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KP728_06155	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
KP728_06160	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
KP728_06220	COG1309	transcriptional regulator
KP728_06255	COG0308	aminopeptidase N
KP728_06260	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KP728_06275	COG0330	HflC and HflK could
KP728_06280	COG0330	HflC and HflK could
KP728_06300	COG0678	peroxiredoxin activity
KP728_06310	COG4953	penicillin-binding protein 1C
KP728_06335	COG2373	Large extracellular alpha-helical protein
KP728_06360	COG3609	addiction module antidote protein, CC2985 family
KP728_06380	COG3829	transcription factor binding
KP728_06405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KP728_06410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KP728_06425	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_06430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KP728_06440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KP728_06445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KP728_06450	COG1399	metal-binding, possibly nucleic acid-binding protein
KP728_06455	COG0424	maF-like protein
KP728_06475	COG0714	Associated with various cellular activities
KP728_06495	COG0537	adenosine 5'-monophosphoramidase activity
KP728_06500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KP728_06505	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KP728_06525	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KP728_06540	COG1401	restriction endodeoxyribonuclease activity
KP728_06565	COG0314	molybdopterin synthase activity
KP728_06570	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KP728_06575	COG0315	cyclic pyranopterin monophosphate synthase activity
KP728_06580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KP728_06585	COG1234	tRNA 3'-trailer cleavage
KP728_06595	COG0859	PFAM glycosyl transferase family 9
KP728_06610	COG0631	protein serine/threonine phosphatase activity
KP728_06630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KP728_06640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KP728_06670	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KP728_06680	COG0544	peptidyl-prolyl cis-trans isomerase activity
KP728_06690	COG3852	Histidine kinase
KP728_06725	COG0473	3-isopropylmalate dehydrogenase activity
KP728_06740	COG4783	chaperone-mediated protein folding
KP728_06755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KP728_06765	COG0438	transferase activity, transferring glycosyl groups
KP728_06770	COG0671	phosphoesterase, PA-phosphatase related
KP728_06775	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KP728_06785	COG3291	Pkd domain containing protein
KP728_06790	COG2833	Protein of unknown function (DUF455)
KP728_06810	COG0285	dihydrofolate synthase activity
KP728_06820	COG0406	alpha-ribazole phosphatase activity
KP728_06850	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KP728_06855	COG4208	sulfate ABC transporter
KP728_06860	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KP728_06865	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KP728_06890	COG2885	chlorophyll binding
KP728_06895	COG0604	alcohol dehydrogenase
KP728_06900	COG0446	pyridine nucleotide-disulphide oxidoreductase
KP728_06900	COG1902	pentaerythritol trinitrate reductase activity
KP728_06915	COG0625	glutathione transferase activity
KP728_06935	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KP728_06940	COG1217	gtp-binding protein TYPA
KP728_06950	COG0154	amidase activity
KP728_06960	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KP728_06970	COG0203	ribosomal protein L17
KP728_06995	COG0201	protein transport
KP728_07005	COG1841	ribosomal large subunit assembly
KP728_07020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KP728_07040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KP728_07055	COG0255	Belongs to the universal ribosomal protein uL29 family
KP728_07070	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KP728_07080	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KP728_07100	COG0051	transcription antitermination factor activity, RNA binding
KP728_07105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KP728_07110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KP728_07120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KP728_07125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KP728_07135	COG0222	ribosome binding
KP728_07140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KP728_07145	COG0081	regulation of translation
KP728_07150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KP728_07155	COG0250	Participates in transcription elongation, termination and antitermination
KP728_07170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KP728_07190	COG0012	GTP binding
KP728_07195	COG0193	aminoacyl-tRNA hydrolase activity
KP728_07200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KP728_07205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KP728_07220	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KP728_07230	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KP728_07235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KP728_07245	COG0521	Mo-molybdopterin cofactor biosynthetic process
KP728_07260	COG1254	Belongs to the acylphosphatase family
KP728_07265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KP728_07270	COG1295	ribonuclease BN
KP728_07290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KP728_07295	COG1404	Belongs to the peptidase S8 family
KP728_07300	COG1404	Belongs to the peptidase S8 family
KP728_07305	COG1404	Belongs to the peptidase S8 family
KP728_07310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KP728_07330	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KP728_07350	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KP728_07375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KP728_07375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KP728_07395	COG2890	protein-(glutamine-N5) methyltransferase activity
KP728_07405	COG3634	alkyl hydroperoxide reductase activity
KP728_07410	COG0583	DNA-binding transcription factor activity
KP728_07415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KP728_07420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KP728_07430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KP728_07440	COG2197	response regulator
KP728_07465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KP728_07470	COG0697	spore germination
KP728_07520	COG1024	Enoyl-CoA hydratase
KP728_07530	COG0318	PFAM AMP-dependent synthetase and ligase
KP728_07535	COG0583	DNA-binding transcription factor activity
KP728_07540	COG3384	dioxygenase
KP728_07570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KP728_07575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KP728_07585	COG2096	Adenosyltransferase
KP728_07590	COG0123	including yeast histone deacetylase and acetoin utilization protein
KP728_07595	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KP728_07605	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KP728_07610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KP728_07615	COG2967	ApaG domain
KP728_07620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KP728_07635	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KP728_07640	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KP728_07660	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KP728_07670	COG0642	Histidine kinase
KP728_07685	COG4181	ATPase activity
KP728_07695	COG2175	clavaminate synthase activity
KP728_07705	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KP728_07710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KP728_07730	COG4771	TonB-dependent receptor
KP728_07740	COG0667	Aldo Keto reductase
KP728_07745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KP728_07755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KP728_07760	COG4106	trans-aconitate 2-methyltransferase activity
KP728_07775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KP728_07790	COG2885	chlorophyll binding
KP728_07810	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KP728_07825	COG2226	methyltransferase
KP728_07850	COG0366	Alpha amylase catalytic
KP728_07870	COG0604	alcohol dehydrogenase
KP728_07870	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_07870	COG3321	synthase
KP728_07875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KP728_07890	COG0494	nUDIX hydrolase
KP728_07900	COG0653	protein targeting
KP728_07905	COG0739	heme binding
KP728_07930	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KP728_07935	COG1181	Belongs to the D-alanine--D-alanine ligase family
KP728_07940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KP728_07960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KP728_07965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KP728_07975	COG3116	cell division
KP728_08010	COG0792	nuclease activity
KP728_08015	COG1988	membrane-bound metal-dependent
KP728_08020	COG0277	FAD linked oxidase domain protein
KP728_08025	COG0823	Involved in the tonB-independent uptake of proteins
KP728_08025	COG1506	peptidase
KP728_08025	COG4946	Tricorn protease homolog
KP728_08030	COG0745	RESPONSE REGULATOR receiver
KP728_08035	COG2205	protein histidine kinase activity
KP728_08040	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
KP728_08045	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KP728_08050	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KP728_08065	COG0697	spore germination
KP728_08075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KP728_08085	COG3791	Glutathione-dependent formaldehyde-activating
KP728_08100	COG3920	Histidine kinase
KP728_08120	COG2205	protein histidine kinase activity
KP728_08135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KP728_08140	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KP728_08155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KP728_08165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KP728_08175	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KP728_08185	COG1522	sequence-specific DNA binding
KP728_08195	COG4977	sequence-specific DNA binding
KP728_08210	COG0617	tRNA 3'-terminal CCA addition
KP728_08220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KP728_08225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KP728_08230	COG1609	Transcriptional regulator
KP728_08240	COG2188	Transcriptional regulator
KP728_08255	COG3250	beta-galactosidase activity
KP728_08280	COG3156	type II secretion system protein K
KP728_08285	COG4795	General secretion pathway protein
KP728_08290	COG2165	general secretion pathway protein
KP728_08305	COG1459	type II secretion system
KP728_08355	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_08360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KP728_08365	COG4191	Histidine kinase
KP728_08370	COG0784	Response regulator, receiver
KP728_08375	COG4251	negative regulation of phosphorylation
KP728_08380	COG2823	Periplasmic or secreted lipoprotein
KP728_08385	COG0673	inositol 2-dehydrogenase activity
KP728_08390	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KP728_08425	COG1051	belongs to the nudix hydrolase family
KP728_08425	COG1056	cytidyltransferase-related domain
KP728_08435	COG0583	DNA-binding transcription factor activity
KP728_08450	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KP728_08455	COG0321	lipoyl(octanoyl) transferase activity
KP728_08460	COG2921	Belongs to the UPF0250 family
KP728_08475	COG1686	Belongs to the peptidase S11 family
KP728_08480	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KP728_08485	COG2951	lytic endotransglycosylase activity
KP728_08495	COG0772	Belongs to the SEDS family
KP728_08510	COG1792	Involved in formation and maintenance of cell shape
KP728_08520	COG1077	Cell shape determining protein MreB Mrl
KP728_08525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KP728_08530	COG3284	Transcriptional regulator
KP728_08540	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KP728_08575	COG0308	aminopeptidase N
KP728_08580	COG5001	Diguanylate cyclase
KP728_08580	COG3300	MHYT domain
KP728_08585	COG2226	methyltransferase
KP728_08615	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KP728_08630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KP728_08640	COG2832	Protein of unknown function (DUF454)
KP728_08650	COG0436	Aminotransferase
KP728_08655	COG1505	serine-type exopeptidase activity
KP728_08680	COG0181	hydroxymethylbilane synthase activity
KP728_08690	COG3275	phosphorelay sensor kinase activity
KP728_08700	COG2943	transferase activity, transferring hexosyl groups
KP728_08715	COG0659	secondary active sulfate transmembrane transporter activity
KP728_08720	COG5297	Belongs to the glycosyl hydrolase family 6
KP728_08720	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KP728_08725	COG0840	transmembrane signaling receptor activity
KP728_08765	COG3507	Belongs to the glycosyl hydrolase 43 family
KP728_08795	COG1113	amino acid transport
KP728_08815	COG0697	spore germination
KP728_08865	COG0823	Involved in the tonB-independent uptake of proteins
KP728_08865	COG1506	peptidase
KP728_08900	COG0435	Glutathione S-transferase
KP728_08945	COG0823	Involved in the tonB-independent uptake of proteins
KP728_08945	COG1506	peptidase
KP728_08950	COG4206	TonB-dependent receptor
KP728_08965	COG1595	DNA-templated transcription, initiation
KP728_09025	COG3852	Histidine kinase
KP728_09070	COG0546	phosphoglycolate phosphatase activity
KP728_09075	COG1802	Transcriptional regulator
KP728_09110	COG3052	prosthetic group binding
KP728_09130	COG2353	YceI-like domain
KP728_09160	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KP728_09185	COG3712	iron ion homeostasis
KP728_09210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KP728_09240	COG2356	endonuclease I
KP728_09245	COG1324	tolerance protein
KP728_09255	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KP728_09260	COG0511	ligase activity, forming carbon-carbon bonds
KP728_09270	COG0439	Biotin carboxylase
KP728_09285	COG2264	protein methyltransferase activity
KP728_09305	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KP728_09325	COG0138	bifunctional purine biosynthesis protein purh
KP728_09330	COG0151	Belongs to the GarS family
KP728_09335	COG1289	transmembrane transporter activity
KP728_09340	COG2814	Major facilitator Superfamily
KP728_09365	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KP728_09380	COG0316	Belongs to the HesB IscA family
KP728_09420	COG1051	belongs to the nudix hydrolase family
KP728_09435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KP728_09445	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
KP728_09460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KP728_09470	COG0134	indole-3-glycerol-phosphate synthase activity
KP728_09475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KP728_09555	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KP728_09635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KP728_09640	COG0625	glutathione transferase activity
KP728_09650	COG0583	DNA-binding transcription factor activity
KP728_09660	COG0583	DNA-binding transcription factor activity
KP728_09665	COG0583	DNA-binding transcription factor activity
KP728_09685	COG1597	lipid kinase activity
KP728_09705	COG0484	heat shock protein binding
KP728_09750	COG2111	Na H antiporter
KP728_09750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KP728_09755	COG1006	Multisubunit Na H antiporter MnhC subunit
KP728_09760	COG0651	ATP synthesis coupled electron transport
KP728_09770	COG2212	antiporter activity
KP728_09775	COG1320	monovalent cation:proton antiporter activity
KP728_09790	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KP728_09815	COG3104	oligopeptide transport
KP728_09830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KP728_09845	COG0508	dehydrogenase complex catalyzes the overall conversion of
KP728_09850	COG0513	Belongs to the DEAD box helicase family
KP728_09860	COG4221	oxidoreductase activity
KP728_09905	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_09910	COG0702	epimerase
KP728_09935	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KP728_09940	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KP728_09945	COG0297	glycogen (starch) synthase activity
KP728_09955	COG2354	Protein conserved in bacteria
KP728_09960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KP728_09965	COG1368	sulfuric ester hydrolase activity
KP728_09970	COG3264	Mechanosensitive ion channel
KP728_09970	COG1511	domain protein
KP728_09995	COG1132	(ABC) transporter
KP728_10000	COG1132	(ABC) transporter
KP728_10000	COG2375	cellular response to nickel ion
KP728_10005	COG4771	TonB-dependent receptor
KP728_10020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KP728_10020	COG2226	methyltransferase
KP728_10020	COG3433	isochorismatase activity
KP728_10045	COG1021	2,3-dihydroxybenzoate-AMP ligase
KP728_10065	COG4771	TonB-dependent receptor
KP728_10095	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KP728_10100	COG1040	competence protein
KP728_10105	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KP728_10110	COG0156	8-amino-7-oxononanoate synthase activity
KP728_10150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KP728_10160	COG0445	tRNA wobble uridine modification
KP728_10180	COG1414	Transcriptional regulator
KP728_10190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KP728_10195	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KP728_10205	COG3485	protocatechuate 3,4-dioxygenase
KP728_10210	COG3485	protocatechuate 3,4-dioxygenase
KP728_10220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KP728_10225	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KP728_10255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KP728_10260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KP728_10305	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KP728_10320	COG0129	dihydroxy-acid dehydratase activity
KP728_10335	COG3039	Transposase
KP728_10350	COG3039	Transposase
KP728_10420	COG0840	transmembrane signaling receptor activity
KP728_10430	COG1733	regulation of RNA biosynthetic process
KP728_10435	COG0702	epimerase
KP728_10465	COG0583	DNA-binding transcription factor activity
KP728_10470	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KP728_10475	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KP728_10515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KP728_10520	COG2205	protein histidine kinase activity
KP728_10525	COG0745	RESPONSE REGULATOR receiver
KP728_10530	COG2223	nitrite transmembrane transporter activity
KP728_10550	COG1902	pentaerythritol trinitrate reductase activity
KP728_10555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KP728_10575	COG1404	Belongs to the peptidase S8 family
KP728_10580	COG2814	Major facilitator Superfamily
KP728_10585	COG0583	DNA-binding transcription factor activity
KP728_10595	COG0084	hydrolase, TatD family'
KP728_10620	COG1957	nucleoside hydrolase
KP728_10670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KP728_10690	COG2072	flavoprotein involved in K transport
KP728_10695	COG2351	hydroxyisourate hydrolase activity
KP728_10700	COG4807	Protein conserved in bacteria
KP728_10705	COG0840	transmembrane signaling receptor activity
KP728_10710	COG1643	Atp-dependent helicase
KP728_10720	COG1187	pseudouridine synthase activity
KP728_10730	COG0667	Aldo Keto reductase
KP728_10735	COG2130	NADP-dependent
KP728_10740	COG0656	L-ascorbic acid biosynthetic process
KP728_10765	COG1764	response to oxidative stress
KP728_10770	COG1846	Transcriptional regulator
KP728_10775	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KP728_10785	COG0697	spore germination
KP728_10795	COG0523	cobalamin synthesis protein
KP728_10850	COG1960	acyl-CoA dehydrogenase activity
KP728_10855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KP728_10860	COG4770	biotin carboxylase activity
KP728_10890	COG2224	Isocitrate lyase
KP728_10895	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KP728_10900	COG0583	DNA-binding transcription factor activity
KP728_10910	COG0475	glutathione-regulated potassium exporter activity
KP728_10940	COG0339	signal peptide processing
KP728_10945	COG1446	asparaginase
KP728_10965	COG0564	pseudouridine synthase activity
KP728_10990	COG1181	Belongs to the D-alanine--D-alanine ligase family
KP728_11005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KP728_11010	COG0318	PFAM AMP-dependent synthetase and ligase
KP728_11015	COG0727	PFAM Uncharacterised protein family (UPF0153)
KP728_11020	COG0596	Alpha beta hydrolase
KP728_11030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KP728_11045	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KP728_11070	COG4191	Histidine kinase
KP728_11075	COG0028	Belongs to the TPP enzyme family
KP728_11085	COG1338	Plays a role in the flagellum-specific transport system
KP728_11110	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KP728_11125	COG1157	protein secretion by the type III secretion system
KP728_11140	COG1766	The M ring may be actively involved in energy transduction
KP728_11145	COG1677	Flagellar hook-basal body complex protein FliE
KP728_11160	COG1706	bacterial-type flagellum-dependent cell motility
KP728_11165	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KP728_11175	COG4786	Flagellar basal body rod
KP728_11180	COG4786	Flagellar basal body rod
KP728_11185	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KP728_11235	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KP728_11245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KP728_11285	COG0183	Belongs to the thiolase family
KP728_11300	COG2032	superoxide dismutase activity
KP728_11305	COG2032	superoxide dismutase activity
KP728_11310	COG2204	response regulator
KP728_11315	COG3852	Histidine kinase
KP728_11320	COG0004	ammonium transporteR
KP728_11325	COG0347	Belongs to the P(II) protein family
KP728_11330	COG0174	glutamine synthetase
KP728_11345	COG1881	PFAM PEBP family protein
KP728_11370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KP728_11380	COG2062	phosphohistidine phosphatase, SixA
KP728_11385	COG0489	protein tyrosine kinase activity
KP728_11415	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
KP728_11420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KP728_11435	COG0517	IMP dehydrogenase activity
KP728_11435	COG1125	glycine betaine transport
KP728_11450	COG1119	ATPase activity
KP728_11460	COG1752	Esterase of the alpha-beta hydrolase superfamily
KP728_11475	COG1522	sequence-specific DNA binding
KP728_11480	COG3186	Phenylalanine-4-hydroxylase
KP728_11495	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KP728_11510	COG2755	lipolytic protein G-D-S-L family
KP728_11520	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_11525	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
KP728_11530	COG1609	Transcriptional regulator
KP728_11535	COG3507	Belongs to the glycosyl hydrolase 43 family
KP728_11550	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KP728_11560	COG0657	acetylesterase activity
KP728_11560	COG2755	lipolytic protein G-D-S-L family
KP728_11605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KP728_11610	COG0366	Alpha amylase catalytic
KP728_11615	COG0366	Alpha amylase catalytic
KP728_11765	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KP728_11785	COG2197	response regulator
KP728_11790	COG4585	Histidine kinase
KP728_11795	COG1755	Isoprenylcysteine carboxyl methyltransferase
KP728_11800	COG1304	FMN binding
KP728_11835	COG1012	belongs to the aldehyde dehydrogenase family
KP728_11840	COG3284	Transcriptional regulator
KP728_11845	COG1126	abc transporter atp-binding protein
KP728_11850	COG0765	amino acid transport
KP728_11855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KP728_11865	COG2423	ornithine cyclodeaminase activity
KP728_11875	COG4772	TonB-dependent receptor
KP728_11900	COG1309	transcriptional regulator
KP728_11945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KP728_11955	COG0657	acetylesterase activity
KP728_11990	COG3237	CsbD-like
KP728_12035	COG3549	Plasmid maintenance system killer
KP728_12040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KP728_12045	COG1074	ATP-dependent DNA helicase activity
KP728_12050	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KP728_12085	COG1127	ABC transporter
KP728_12090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KP728_12095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KP728_12110	COG2853	Lipoprotein
KP728_12120	COG0386	Belongs to the glutathione peroxidase family
KP728_12130	COG1322	Protein conserved in bacteria
KP728_12140	COG0531	amino acid
KP728_12145	COG3537	Alpha-1,2-mannosidase
KP728_12165	COG3706	GGDEF domain
KP728_12170	COG3835	regulator
KP728_12175	COG1929	Belongs to the glycerate kinase type-1 family
KP728_12180	COG2271	Major facilitator Superfamily
KP728_12230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KP728_12235	COG0861	Integral membrane protein TerC family
KP728_12245	COG0584	glycerophosphoryl diester phosphodiesterase
KP728_12255	COG0671	phosphoesterase, PA-phosphatase related
KP728_12275	COG0706	membrane insertase activity
KP728_12290	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KP728_12305	COG0187	DNA topoisomerase II activity
KP728_12315	COG0501	Belongs to the peptidase M48B family
KP728_12350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KP728_12360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KP728_12395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KP728_12400	COG0793	Belongs to the peptidase S41A family
KP728_12405	COG4942	peptidase
KP728_12415	COG2234	aminopeptidase activity
KP728_12425	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KP728_12430	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KP728_12435	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KP728_12440	COG1064	alcohol dehydrogenase
KP728_12450	COG0493	'glutamate synthase
KP728_12455	COG0069	glutamate synthase activity
KP728_12455	COG0070	glutamate synthase
KP728_12455	COG0067	glutamate synthase
KP728_12490	COG3459	Glycosyltransferase 36 associated
KP728_12535	COG1111	helicase
KP728_12535	COG1205	dead DEAH box helicase
KP728_12540	COG1272	protein, Hemolysin III
KP728_12580	COG0583	DNA-binding transcription factor activity
KP728_12585	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_12630	COG0564	pseudouridine synthase activity
KP728_12700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KP728_12705	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
KP728_12715	COG0477	Major facilitator Superfamily
KP728_12720	COG1289	transmembrane transporter activity
KP728_12730	COG1566	PFAM secretion protein HlyD family protein
KP728_12745	COG0302	gtp cyclohydrolase
KP728_12770	COG0730	response to heat
KP728_12780	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_12795	COG0676	glucose-6-phosphate 1-epimerase activity
KP728_12820	COG3135	benzoate transporter
KP728_12855	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KP728_12865	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
KP728_12875	COG1435	thymidine kinase activity
KP728_12880	COG0210	DNA helicase
KP728_12895	COG3132	Protein of unknown function, DUF480
KP728_12900	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KP728_12905	COG0284	orotidine-5'-phosphate decarboxylase activity
KP728_12935	COG2937	Belongs to the GPAT DAPAT family
KP728_12940	COG3321	synthase
KP728_12940	COG0604	alcohol dehydrogenase
KP728_12940	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_13005	COG1904	glucuronate isomerase
KP728_13020	COG3386	PFAM SMP-30 Gluconolaconase
KP728_13035	COG1620	l-lactate permease
KP728_13065	COG0246	Mannitol dehydrogenase
KP728_13070	COG1472	Belongs to the glycosyl hydrolase 3 family
KP728_13080	COG4948	Mandelate Racemase Muconate Lactonizing
KP728_13090	COG3661	Belongs to the glycosyl hydrolase 67 family
KP728_13100	COG2115	Belongs to the xylose isomerase family
KP728_13105	COG0037	tRNA processing
KP728_13110	COG2974	May be involved in recombination
KP728_13125	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KP728_13135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KP728_13140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KP728_13145	COG0805	protein transport
KP728_13155	COG0519	Catalyzes the synthesis of GMP from XMP
KP728_13155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KP728_13160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KP728_13175	COG0457	Tetratricopeptide repeat
KP728_13180	COG4771	TonB-dependent receptor
KP728_13185	COG0729	surface antigen
KP728_13190	COG2911	Protein conserved in bacteria
KP728_13210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KP728_13220	COG3265	gluconokinase activity
KP728_13225	COG2211	Major facilitator Superfamily
KP728_13230	COG3459	Glycosyltransferase 36 associated
KP728_13235	COG2205	protein histidine kinase activity
KP728_13240	COG1971	Probably functions as a manganese efflux pump
KP728_13245	COG1414	Transcriptional regulator
KP728_13250	COG0738	Major facilitator superfamily
KP728_13255	COG3254	rhamnose metabolic process
KP728_13260	COG4948	Mandelate Racemase Muconate Lactonizing
KP728_13265	COG0179	Fumarylacetoacetate (FAA) hydrolase
KP728_13270	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_13285	COG3507	Belongs to the glycosyl hydrolase 43 family
KP728_13315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KP728_13330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KP728_13340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KP728_13350	COG1940	carbohydrate kinase activity
KP728_13370	COG2091	lysine biosynthetic process via aminoadipic acid
KP728_13380	COG3540	Alkaline phosphatase
KP728_13405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KP728_13425	COG2159	amidohydrolase
KP728_13435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KP728_13440	COG0583	DNA-binding transcription factor activity
KP728_13445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KP728_13455	COG0210	DNA helicase
KP728_13535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KP728_13550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KP728_13580	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_13605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KP728_13610	COG3100	YcgL domain-containing protein
KP728_13625	COG3387	PFAM Glycoside hydrolase 15-related
KP728_13630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KP728_13640	COG2239	Acts as a magnesium transporter
KP728_13645	COG1629	transport
KP728_13645	COG4771	TonB-dependent receptor
KP728_13660	COG0045	succinate-CoA ligase (ADP-forming) activity
KP728_13660	COG1042	CoA-binding domain protein
KP728_13660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KP728_13670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KP728_13675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KP728_13690	COG1607	acyl-coa hydrolase
KP728_13700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KP728_13705	COG0842	Transport permease protein
KP728_13710	COG1131	(ABC) transporter
KP728_13745	COG1476	TRANSCRIPTIONal
KP728_13755	COG4555	ABC transporter
KP728_13795	COG0625	glutathione transferase activity
KP728_13855	COG1199	ATP-dependent helicase activity
KP728_13880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KP728_13920	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KP728_13920	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KP728_13925	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KP728_13940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KP728_13980	COG3237	CsbD-like
KP728_13985	COG0180	Tryptophanyl-tRNA synthetase
KP728_14010	COG0697	spore germination
KP728_14035	COG1136	(ABC) transporter
KP728_14040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KP728_14045	COG4585	Histidine kinase
KP728_14050	COG2197	response regulator
KP728_14080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KP728_14085	COG1011	Hydrolase
KP728_14090	COG0628	permease
KP728_14130	COG0642	Histidine kinase
KP728_14140	COG1090	epimerase
KP728_14195	COG4943	cyclic-guanylate-specific phosphodiesterase activity
KP728_14210	COG0606	chelatase, subunit chli
KP728_14275	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KP728_14280	COG1166	arginine decarboxylase activity
KP728_14285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KP728_14285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KP728_14295	COG2755	lipolytic protein G-D-S-L family
KP728_14295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KP728_14300	COG4221	oxidoreductase activity
KP728_14315	COG0018	arginyl-trna synthetase
KP728_14325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KP728_14350	COG0463	Glycosyl transferase, family 2
KP728_14370	COG1475	DNA binding
KP728_14375	COG1192	Involved in chromosome partitioning
KP728_14390	COG0708	Exodeoxyribonuclease III
KP728_14395	COG2211	Major facilitator Superfamily
KP728_14410	COG0739	heme binding
KP728_14455	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KP728_14470	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
KP728_14500	COG0109	protoheme IX farnesyltransferase activity
KP728_14520	COG0358	DNA primase activity
KP728_14525	COG1295	ribonuclease BN
KP728_14530	COG1610	YqeY-like protein
KP728_14545	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KP728_14555	COG2133	pyrroloquinoline quinone binding
KP728_14560	COG4682	membrane
KP728_14575	COG0531	amino acid
KP728_14585	COG4948	Mandelate Racemase Muconate Lactonizing
KP728_14595	COG3023	N-Acetylmuramoyl-L-alanine amidase
KP728_14600	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
KP728_14645	COG5383	Protein conserved in bacteria
KP728_14655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KP728_14665	COG1473	amidohydrolase
KP728_14670	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KP728_14670	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KP728_14690	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
KP728_14705	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KP728_14710	COG3118	belongs to the thioredoxin family
KP728_14720	COG2884	Cell division ATP-binding protein ftsE
KP728_14725	COG2177	Part of the ABC transporter FtsEX involved in
KP728_14730	COG2201	protein-glutamate methylesterase activity
KP728_14735	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KP728_14740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KP728_14745	COG2860	membrane
KP728_14750	COG1252	NADH dehydrogenase
KP728_14770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KP728_14785	COG0534	Mate efflux family protein
KP728_14790	COG0616	signal peptide processing
KP728_14800	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_14815	COG0009	L-threonylcarbamoyladenylate synthase
KP728_14820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KP728_14820	COG1754	DNA topoisomerase type I activity
KP728_14840	COG0758	DNA mediated transformation
KP728_14845	COG1652	LysM domain
KP728_14850	COG0242	peptide deformylase activity
KP728_14860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KP728_14860	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KP728_14895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KP728_14910	COG1490	D-aminoacyl-tRNA deacylase activity
KP728_14915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KP728_14980	COG0419	ATPase involved in DNA repair
KP728_15000	COG0582	viral genome integration into host DNA
KP728_15115	COG0024	Methionine aminopeptidase
KP728_15120	COG0038	chloride channel
KP728_15125	COG0659	secondary active sulfate transmembrane transporter activity
KP728_15170	COG1131	(ABC) transporter
KP728_15210	COG2814	Major facilitator Superfamily
KP728_15215	COG0583	DNA-binding transcription factor activity
KP728_15240	COG1063	alcohol dehydrogenase
KP728_15250	COG1132	(ABC) transporter
KP728_15270	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_15280	COG2204	response regulator
KP728_15305	COG3546	catalase activity
KP728_15310	COG3685	Protein conserved in bacteria
KP728_15330	COG2972	Histidine kinase
KP728_15345	COG0531	amino acid
KP728_15360	COG3590	peptidase
KP728_15370	COG0667	Aldo Keto reductase
KP728_15380	COG0583	DNA-binding transcription factor activity
KP728_15390	COG3384	dioxygenase
KP728_15405	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
KP728_15415	COG0025	NhaP-type Na H and K H
KP728_15420	COG1131	(ABC) transporter
KP728_15425	COG0842	Transport permease protein
KP728_15485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KP728_15490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KP728_15515	COG2205	protein histidine kinase activity
KP728_15515	COG2202	Pas domain
KP728_15540	COG1187	pseudouridine synthase activity
KP728_15560	COG0784	Response regulator, receiver
KP728_15560	COG5002	protein histidine kinase activity
KP728_15560	COG2198	Histidine kinase
KP728_15570	COG1666	GTP binding
KP728_15575	COG0697	spore germination
KP728_15580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KP728_15585	COG2011	ABC-type metal ion transport system permease component
KP728_15620	COG0508	dehydrogenase complex catalyzes the overall conversion of
KP728_15630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KP728_15645	COG0356	it plays a direct role in the translocation of protons across the membrane
KP728_15655	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KP728_15660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KP728_15680	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KP728_15695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KP728_15705	COG4191	Histidine kinase
KP728_15715	COG0577	efflux transmembrane transporter activity
KP728_15715	COG1136	(ABC) transporter
KP728_15720	COG1136	(ABC) transporter
KP728_15720	COG0577	efflux transmembrane transporter activity
KP728_15725	COG1136	(ABC) transporter
KP728_15735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KP728_15740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KP728_15790	COG0339	signal peptide processing
KP728_15805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KP728_15810	COG0546	phosphoglycolate phosphatase activity
KP728_15820	COG2819	hydrolase of the alpha beta superfamily
KP728_15830	COG1956	GAF domain-containing protein
KP728_15835	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KP728_15845	COG0720	synthase
KP728_15850	COG4771	TonB-dependent receptor
KP728_15860	COG0513	Belongs to the DEAD box helicase family
KP728_15870	COG0625	glutathione transferase activity
KP728_15900	COG0626	cystathionine gamma-synthase activity
KP728_15940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KP728_15945	COG0300	oxidoreductase activity
KP728_15950	COG0277	FAD linked oxidase domain protein
KP728_15955	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KP728_15955	COG0546	phosphoglycolate phosphatase activity
KP728_15970	COG2086	electron transfer activity
KP728_15995	COG0662	Cupin 2, conserved barrel domain protein
KP728_15995	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KP728_16000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KP728_16005	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KP728_16035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KP728_16035	COG3218	ABC-type transport auxiliary lipoprotein component
KP728_16040	COG1127	ABC transporter
KP728_16045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KP728_16060	COG0442	prolyl-tRNA aminoacylation
KP728_16070	COG1183	phosphatidylcholine synthase activity
KP728_16090	COG0525	valine-tRNA ligase activity
KP728_16110	COG0795	lipopolysaccharide-transporting ATPase activity
KP728_16120	COG4974	Belongs to the 'phage' integrase family
KP728_16125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KP728_16130	COG0047	phosphoribosylformylglycinamidine synthase activity
KP728_16130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KP728_16135	COG5295	Hep Hag repeat protein
KP728_16140	COG1404	Belongs to the peptidase S8 family
KP728_16150	COG1404	Belongs to the peptidase S8 family
KP728_16155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KP728_16160	COG1459	type II secretion system
KP728_16165	COG2165	general secretion pathway protein
KP728_16170	COG4970	Tfp pilus assembly protein FimT
KP728_16175	COG2165	general secretion pathway protein
KP728_16180	COG4795	General secretion pathway protein
KP728_16185	COG3156	type II secretion system protein K
KP728_16190	COG3166	PFAM Fimbrial assembly family protein
KP728_16205	COG1450	Type ii and iii secretion system protein
KP728_16215	COG2188	Transcriptional regulator
KP728_16275	COG1215	transferase activity, transferring glycosyl groups
KP728_16280	COG1215	transferase activity, transferring glycosyl groups
KP728_16285	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KP728_16290	COG0457	Tetratricopeptide repeat
KP728_16310	COG0242	peptide deformylase activity
KP728_16315	COG0488	(ABC) transporter
KP728_16325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KP728_16340	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KP728_16340	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KP728_16370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KP728_16375	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KP728_16405	COG1228	amidohydrolase
KP728_16410	COG3964	amidohydrolase
KP728_16425	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KP728_16430	COG0726	polysaccharide deacetylase
KP728_16435	COG4773	Receptor
KP728_16485	COG2211	Major facilitator Superfamily
KP728_16490	COG1609	Transcriptional regulator
KP728_16495	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_16500	COG2851	Citrate transporter
KP728_16515	COG0642	Histidine kinase
KP728_16525	COG2197	response regulator
KP728_16530	COG0667	Aldo Keto reductase
KP728_16540	COG0583	DNA-binding transcription factor activity
KP728_16555	COG4191	Histidine kinase
KP728_16570	COG0280	phosphate acetyltransferase
KP728_16570	COG0281	malic enzyme
KP728_16595	COG1560	Kdo2-lipid A biosynthetic process
KP728_16600	COG1519	Transferase
KP728_16605	COG1538	Outer membrane efflux protein
KP728_16610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KP728_16630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KP728_16635	COG0066	3-isopropylmalate dehydratase activity
KP728_16640	COG2226	methyltransferase
KP728_16645	COG0473	3-isopropylmalate dehydrogenase activity
KP728_16650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KP728_16670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KP728_16675	COG0405	Gamma-glutamyltransferase
KP728_16680	COG0840	transmembrane signaling receptor activity
KP728_16685	COG4946	Tricorn protease homolog
KP728_16685	COG0823	Involved in the tonB-independent uptake of proteins
KP728_16685	COG1506	peptidase
KP728_16700	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KP728_16705	COG3710	Transcriptional regulator
KP728_16725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KP728_16735	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KP728_16750	COG0563	adenylate kinase activity
KP728_16755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KP728_16765	COG3781	membrane
KP728_16770	COG0671	phosphoesterase, PA-phosphatase related
KP728_16780	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_16800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KP728_16830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KP728_16835	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
KP728_16850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KP728_16860	COG0352	thiamine-phosphate diphosphorylase activity
KP728_16865	COG1773	rubredoxin
KP728_16870	COG2912	Transglutaminase-like superfamily
KP728_16890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KP728_16915	COG0006	proline dipeptidase activity
KP728_16920	COG0006	proline dipeptidase activity
KP728_16935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KP728_16950	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KP728_16955	COG1561	YicC-like family, N-terminal region
KP728_16970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KP728_16980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KP728_17005	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KP728_17035	COG0714	Associated with various cellular activities
KP728_17065	COG1301	dicarboxylic acid transport
KP728_17070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KP728_17075	COG4773	Receptor
KP728_17080	COG0583	DNA-binding transcription factor activity
KP728_17085	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_17090	COG0739	heme binding
KP728_17095	COG1376	ErfK ybiS ycfS ynhG family protein
KP728_17145	COG4149	molybdate abc transporter
KP728_17150	COG0725	ABC transporter, periplasmic molybdate-binding protein
KP728_17155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KP728_17155	COG3453	Protein conserved in bacteria
KP728_17165	COG3047	cAMP biosynthetic process
KP728_17180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KP728_17210	COG0469	pyruvate kinase activity
KP728_17215	COG3588	fructose-bisphosphate aldolase
KP728_17220	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KP728_17235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KP728_17235	COG1648	precorrin-2 dehydrogenase activity
KP728_17250	COG0784	Response regulator, receiver
KP728_17250	COG2198	Histidine kinase
KP728_17250	COG2205	protein histidine kinase activity
KP728_17270	COG0175	sulfate reduction
KP728_17275	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KP728_17280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KP728_17290	COG2895	sulfate adenylyltransferase (ATP) activity
KP728_17290	COG0529	Catalyzes the synthesis of activated sulfate
KP728_17295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KP728_17300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KP728_17330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KP728_17335	COG2272	Belongs to the type-B carboxylesterase lipase family
KP728_17345	COG4948	Mandelate Racemase Muconate Lactonizing
KP728_17350	COG3250	beta-galactosidase activity
KP728_17360	COG1609	Transcriptional regulator
KP728_17370	COG1970	mechanosensitive ion channel activity
KP728_17390	COG0471	metal ion transport
KP728_17390	COG3273	potassium ion transport
KP728_17395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KP728_17420	COG0582	viral genome integration into host DNA
KP728_17430	COG1396	sequence-specific DNA binding
KP728_17485	COG0583	DNA-binding transcription factor activity
KP728_17510	COG0583	DNA-binding transcription factor activity
KP728_17515	COG2814	Major facilitator Superfamily
KP728_17520	COG0583	DNA-binding transcription factor activity
KP728_17525	COG2814	Major facilitator Superfamily
KP728_17530	COG0657	acetylesterase activity
KP728_17535	COG0583	DNA-binding transcription factor activity
KP728_17595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KP728_17610	COG2189	Belongs to the N(4) N(6)-methyltransferase family
KP728_17720	COG0270	DNA (cytosine-5-)-methyltransferase activity
KP728_17725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KP728_17765	COG2894	cell division
KP728_17795	COG0189	ligase activity
KP728_17805	COG0745	RESPONSE REGULATOR receiver
KP728_17825	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KP728_17830	COG1459	type II secretion system
KP728_17835	COG4969	Belongs to the N-Me-Phe pilin family
KP728_17855	COG0045	succinate-CoA ligase (ADP-forming) activity
KP728_17880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KP728_17880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KP728_17890	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KP728_17895	COG0564	pseudouridine synthase activity
KP728_17900	COG1496	oxidoreductase activity
KP728_17910	COG0840	transmembrane signaling receptor activity
KP728_17925	COG3387	PFAM Glycoside hydrolase 15-related
KP728_17930	COG1877	trehalose-phosphatase activity
KP728_17975	COG4771	TonB-dependent receptor
KP728_17980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KP728_17985	COG0667	Aldo Keto reductase
KP728_17990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KP728_17995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KP728_18000	COG1116	anion transmembrane transporter activity
KP728_18005	COG0542	response to heat
KP728_18015	COG4206	TonB-dependent receptor
KP728_18025	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KP728_18040	COG0019	diaminopimelate decarboxylase activity
KP728_18045	COG4264	IucA IucC family
KP728_18055	COG4264	IucA IucC family
KP728_18065	COG4772	TonB-dependent receptor
KP728_18075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KP728_18075	COG4651	solute:proton antiporter activity
KP728_18105	COG0488	(ABC) transporter
KP728_18140	COG0477	Major facilitator Superfamily
KP728_18195	COG2255	four-way junction helicase activity
KP728_18200	COG0824	Thioesterase
KP728_18210	COG0848	biopolymer transport protein
KP728_18220	COG0823	Involved in the tonB-independent uptake of proteins
KP728_18225	COG2885	chlorophyll binding
KP728_18235	COG0602	queuosine metabolic process
KP728_18265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KP728_18285	COG0840	transmembrane signaling receptor activity
KP728_18295	COG1187	pseudouridine synthase activity
KP728_18315	COG0514	ATP-dependent DNA helicase (RecQ)
KP728_18320	COG0783	Belongs to the Dps family
KP728_18325	COG1643	Atp-dependent helicase
KP728_18340	COG0837	glucose binding
KP728_18355	COG0535	radical SAM domain protein
KP728_18365	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
KP728_18370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KP728_18380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KP728_18390	COG1215	transferase activity, transferring glycosyl groups
KP728_18395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KP728_18405	COG1199	ATP-dependent helicase activity
KP728_18415	COG1397	ADP-ribosylglycohydrolase
KP728_18425	COG0189	ligase activity
KP728_18440	COG0835	chemotaxis
KP728_18445	COG0840	transmembrane signaling receptor activity
KP728_18450	COG0784	Response regulator, receiver
KP728_18450	COG2198	Histidine kinase
KP728_18450	COG0643	Histidine kinase
KP728_18475	COG1595	DNA-templated transcription, initiation
KP728_18485	COG1446	asparaginase
KP728_18490	COG3142	Participates in the control of copper homeostasis
KP728_18520	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KP728_18535	COG3645	SOS response
KP728_18575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KP728_18615	COG3537	Alpha-1,2-mannosidase
KP728_18625	COG1486	melibiose metabolic process
KP728_18635	COG0531	amino acid
KP728_18650	COG1472	Belongs to the glycosyl hydrolase 3 family
KP728_18660	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KP728_18665	COG1388	LysM domain
KP728_18665	COG3858	chitin binding
KP728_18680	COG0837	glucose binding
KP728_18685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KP728_18695	COG0494	nUDIX hydrolase
KP728_18705	COG3956	TIGRFAM MazG family protein
KP728_18710	COG1742	UPF0060 membrane protein
KP728_18715	COG0330	HflC and HflK could
KP728_18725	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KP728_18730	COG0509	glycine decarboxylation via glycine cleavage system
KP728_18760	COG1960	acyl-CoA dehydrogenase activity
KP728_18770	COG1309	transcriptional regulator
KP728_18775	COG4771	TonB-dependent receptor
KP728_18785	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KP728_18790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KP728_18795	COG0463	Glycosyl transferase, family 2
KP728_18800	COG0516	GMP reductase activity
KP728_18800	COG0517	IMP dehydrogenase activity
KP728_18805	COG2982	Protein involved in outer membrane biogenesis
KP728_18810	COG1272	protein, Hemolysin III
KP728_18815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KP728_18820	COG0739	heme binding
KP728_18825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KP728_18830	COG0626	cystathionine gamma-synthase activity
KP728_18835	COG0460	homoserine dehydrogenase
KP728_18835	COG0527	aspartate kinase activity
KP728_18845	COG1760	l-serine dehydratase
KP728_18860	COG3038	cytochrome b561
KP728_18865	COG2353	YceI-like domain
KP728_18870	COG2205	protein histidine kinase activity
KP728_18870	COG2198	Histidine kinase
KP728_18870	COG0784	Response regulator, receiver
KP728_18880	COG0477	Major facilitator Superfamily
KP728_18885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KP728_18895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KP728_18900	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KP728_18920	COG1842	Phage shock protein A
KP728_18945	COG0754	glutathionylspermidine amidase activity
KP728_18950	COG2814	Major facilitator Superfamily
KP728_18990	COG0531	amino acid
KP728_18995	COG2197	response regulator
KP728_19010	COG1113	amino acid transport
KP728_19025	COG1271	oxidase subunit
KP728_19030	COG1294	oxidase, subunit
KP728_19040	COG2239	Acts as a magnesium transporter
KP728_19045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KP728_19050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KP728_19070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KP728_19085	COG1137	ATPase activity
KP728_19090	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KP728_19100	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KP728_19110	COG0271	Belongs to the BolA IbaG family
KP728_19135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KP728_19155	COG0628	permease
KP728_19165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KP728_19170	COG3178	'Phosphotransferase
KP728_19180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KP728_19185	COG1555	photosystem II stabilization
KP728_19200	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KP728_19205	COG1477	protein flavinylation
KP728_19230	COG3128	pkhd-type hydroxylase
KP728_19235	COG4774	siderophore transport
KP728_19240	COG2146	nitrite reductase [NAD(P)H] activity
KP728_19250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KP728_19255	COG0719	Fe-S assembly protein
KP728_19260	COG0396	ATPase activity
KP728_19265	COG0719	Fe-S assembly protein
KP728_19270	COG1959	2 iron, 2 sulfur cluster binding
KP728_19280	COG0693	protein deglycase activity
KP728_19300	COG4942	peptidase
KP728_19315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KP728_19335	COG0519	Catalyzes the synthesis of GMP from XMP
KP728_19340	COG1678	Uncharacterized ACR, COG1678
KP728_19345	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KP728_19350	COG0540	Belongs to the ATCase OTCase family
KP728_19355	COG1764	response to oxidative stress
KP728_19365	COG0384	phenazine biosynthesis protein PhzF
KP728_19370	COG0384	phenazine biosynthesis protein PhzF
KP728_19375	COG0527	aspartate kinase activity
KP728_19400	COG0142	geranyltranstransferase activity
KP728_19405	COG0629	single-stranded DNA binding
KP728_19410	COG3706	GGDEF domain
KP728_19410	COG2203	Gaf domain
KP728_19410	COG4251	negative regulation of phosphorylation
KP728_19410	COG5001	Diguanylate cyclase
KP728_19415	COG1028	Short-chain dehydrogenase reductase Sdr
KP728_19415	COG3321	synthase
KP728_19415	COG0604	alcohol dehydrogenase
KP728_19420	COG2080	2 iron, 2 sulfur cluster binding
KP728_19425	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KP728_19430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KP728_19435	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KP728_19470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KP728_19475	COG2879	small protein
KP728_19480	COG1966	Carbon starvation protein
KP728_19485	COG1741	Belongs to the pirin family
KP728_19500	COG1741	Belongs to the pirin family
KP728_19505	COG1515	deoxyribonuclease V activity
KP728_19510	COG0588	phosphoglycerate mutase activity
KP728_19520	COG3590	peptidase
KP728_19525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KP728_19535	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KP728_19540	COG2199	diguanylate cyclase activity
KP728_19540	COG2202	Pas domain
KP728_19540	COG2200	EAL domain
KP728_19545	COG0835	chemotaxis
KP728_19550	COG0840	transmembrane signaling receptor activity
KP728_19555	COG2198	Histidine kinase
KP728_19555	COG0643	Histidine kinase
KP728_19565	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KP728_19575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KP728_19580	COG0745	RESPONSE REGULATOR receiver
KP728_19585	COG2205	protein histidine kinase activity
KP728_19600	COG4452	Inner membrane protein CreD
KP728_19625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KP728_19630	COG0735	belongs to the Fur family
KP728_19670	COG2207	Transcriptional regulator
KP728_19680	COG0583	DNA-binding transcription factor activity
KP728_19685	COG2814	Major facilitator Superfamily
KP728_19690	COG0667	Aldo Keto reductase
KP728_19705	COG1404	Belongs to the peptidase S8 family
KP728_19715	COG1404	Belongs to the peptidase S8 family
KP728_19830	COG5001	Diguanylate cyclase
KP728_19830	COG5002	protein histidine kinase activity
KP728_19835	COG1187	pseudouridine synthase activity
KP728_19855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KP728_19865	COG0475	glutathione-regulated potassium exporter activity
KP728_19875	COG1132	(ABC) transporter
KP728_19915	COG2155	Conserved Protein
KP728_19940	COG3118	belongs to the thioredoxin family
KP728_19950	COG0495	leucyl-tRNA aminoacylation
KP728_19965	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KP728_19985	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KP728_19995	COG2968	Membrane
KP728_20000	COG0424	maF-like protein
KP728_20010	COG3164	Protein of unknown function
KP728_20020	COG0312	modulator of DNA gyrase
KP728_20030	COG0312	modulator of DNA gyrase
KP728_20045	COG0142	geranyltranstransferase activity
KP728_20050	COG1722	exodeoxyribonuclease VII activity
KP728_20055	COG0037	tRNA processing
KP728_20060	COG1785	Belongs to the alkaline phosphatase family
KP728_20065	COG1301	dicarboxylic acid transport
KP728_20080	COG0791	NLP P60 protein
KP728_20085	COG0791	NLP P60 protein
KP728_20090	COG1047	Peptidyl-prolyl cis-trans
KP728_20095	COG2311	Membrane
KP728_20100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KP728_20105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KP728_20130	COG3590	peptidase
KP728_20135	COG3590	peptidase
KP728_20165	COG0489	protein tyrosine kinase activity
KP728_20170	COG0717	Belongs to the dCTP deaminase family
KP728_20270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KP728_20285	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KP728_20295	COG0497	DNA recombination
KP728_20300	COG1420	regulation of RNA biosynthetic process
KP728_20305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KP728_20310	COG0443	Heat shock 70 kDa protein
KP728_20315	COG0484	heat shock protein binding
KP728_20320	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
KP728_20325	COG1605	Chorismate mutase
KP728_20325	COG0287	Prephenate dehydrogenase
KP728_20350	COG0583	DNA-binding transcription factor activity
KP728_20355	COG1132	(ABC) transporter
KP728_20365	COG1619	proteins homologs of microcin C7 resistance protein MccF
KP728_20400	COG2850	peptidyl-arginine hydroxylation
KP728_20415	COG1253	flavin adenine dinucleotide binding
KP728_20445	COG1131	(ABC) transporter
KP728_20450	COG1725	Transcriptional regulator
KP728_20460	COG0386	Belongs to the glutathione peroxidase family
KP728_20475	COG2900	Belongs to the SlyX family
KP728_20500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KP728_20510	COG1410	methionine synthase
KP728_20510	COG0646	methionine synthase
KP728_20515	COG0646	methionine synthase
KP728_20515	COG1410	methionine synthase
KP728_20520	COG2226	methyltransferase
KP728_20525	COG1960	acyl-CoA dehydrogenase activity
KP728_20540	COG0557	exoribonuclease II activity
KP728_20550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KP728_20565	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KP728_20575	COG0704	Plays a role in the regulation of phosphate uptake
KP728_20580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KP728_20585	COG0581	inorganic phosphate transmembrane transporter activity
KP728_20590	COG0573	inorganic phosphate transmembrane transporter activity
KP728_20595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KP728_20620	COG0659	secondary active sulfate transmembrane transporter activity
KP728_20625	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KP728_20635	COG1024	Enoyl-CoA hydratase
KP728_20645	COG0494	nUDIX hydrolase
KP728_20685	COG0488	(ABC) transporter
KP728_20700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KP728_20710	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KP728_20725	COG2925	Exonuclease
KP728_20730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KP728_20735	COG3844	kynureninase activity
KP728_20750	COG0288	reversible hydration of carbon dioxide
KP728_20795	COG2808	Putative FMN-binding domain
KP728_20815	COG0017	Asparaginyl-tRNA synthetase
KP728_20820	COG0316	Belongs to the HesB IscA family
KP728_20845	COG3115	cell septum assembly
KP728_20855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KP728_20860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KP728_20865	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KP728_20875	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KP728_20885	COG4993	Dehydrogenase
KP728_20900	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KP728_20910	COG2986	histidine ammonia-lyase
KP728_20915	COG1228	amidohydrolase
KP728_20950	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
KP728_20955	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KP728_20960	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KP728_20965	COG0077	Prephenate dehydratase
KP728_20965	COG1605	Chorismate mutase
KP728_20970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KP728_20985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KP728_20990	COG0583	DNA-binding transcription factor activity
KP728_21020	COG2003	Belongs to the UPF0758 family
KP728_21050	COG2944	sequence-specific DNA binding
KP728_21070	COG1401	restriction endodeoxyribonuclease activity
KP728_21195	COG0840	transmembrane signaling receptor activity
KP728_21215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KP728_21230	COG0840	transmembrane signaling receptor activity
KP728_21250	COG0784	Response regulator, receiver
KP728_21250	COG4191	Histidine kinase
KP728_21255	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KP728_21260	COG4191	Histidine kinase
KP728_21260	COG0784	Response regulator, receiver
KP728_21275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KP728_21295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KP728_21300	COG1404	Belongs to the peptidase S8 family
KP728_21310	COG1595	DNA-templated transcription, initiation
KP728_21360	COG2244	polysaccharide biosynthetic process
KP728_21390	COG2264	protein methyltransferase activity
KP728_21395	COG0438	transferase activity, transferring glycosyl groups
KP728_21400	COG0438	transferase activity, transferring glycosyl groups
KP728_21420	COG1136	(ABC) transporter
KP728_21425	COG1132	(ABC) transporter
KP728_21430	COG0477	Major facilitator Superfamily
KP728_21435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KP728_21450	COG1253	flavin adenine dinucleotide binding
KP728_21500	COG0148	phosphopyruvate hydratase activity
KP728_21510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KP728_21515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KP728_21525	COG2840	Smr protein MutS2
KP728_21530	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KP728_21535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KP728_21540	COG1238	metal cluster binding
KP728_21555	COG1534	Rna-binding protein
KP728_21560	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KP728_21570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KP728_21585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KP728_21590	COG1546	Belongs to the CinA family
KP728_21595	COG4771	TonB-dependent receptor
KP728_21600	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KP728_21610	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KP728_21615	COG2137	regulation of response to DNA damage stimulus
KP728_21620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KP728_21625	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KP728_21645	COG1741	Belongs to the pirin family
KP728_21650	COG0583	DNA-binding transcription factor activity
KP728_21675	COG0351	phosphomethylpyrimidine kinase
KP728_21675	COG0352	thiamine-phosphate diphosphorylase activity
KP728_21690	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KP728_21695	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KP728_21710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KP728_21720	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KP728_21725	COG3734	2-keto-3-deoxy-galactonokinase
KP728_21735	COG4948	Mandelate Racemase Muconate Lactonizing
KP728_21740	COG0800	Aldolase
KP728_21775	COG1501	Belongs to the glycosyl hydrolase 31 family
KP728_21785	COG1070	Carbohydrate kinase
KP728_21790	COG2115	Belongs to the xylose isomerase family
KP728_21795	COG0477	Major facilitator Superfamily
KP728_21810	COG0860	N-Acetylmuramoyl-L-alanine amidase
KP728_21835	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KP728_21840	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KP728_21870	COG1472	Belongs to the glycosyl hydrolase 3 family
KP728_21880	COG4251	negative regulation of phosphorylation
KP728_21880	COG3706	GGDEF domain
KP728_21880	COG2203	Gaf domain
KP728_21880	COG5001	Diguanylate cyclase
KP728_21885	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KP728_21890	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
KP728_21900	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KP728_21905	COG0671	phosphoesterase, PA-phosphatase related
KP728_21915	COG1794	racemase activity, acting on amino acids and derivatives
KP728_21925	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KP728_21945	COG1012	belongs to the aldehyde dehydrogenase family
KP728_21960	COG1215	transferase activity, transferring glycosyl groups
KP728_21965	COG1649	PFAM Uncharacterised BCR, COG1649
KP728_21965	COG0726	polysaccharide deacetylase
KP728_22015	COG0460	homoserine dehydrogenase
KP728_22015	COG0527	aspartate kinase activity
KP728_22040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KP728_22045	COG0124	histidyl-tRNA synthetase
KP728_22060	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KP728_22065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KP728_22070	COG0131	Imidazoleglycerol-phosphate dehydratase
KP728_22070	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KP728_22075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KP728_22080	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KP728_22090	COG0140	phosphoribosyl-ATP diphosphatase activity
KP728_22090	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KP728_22120	COG0531	amino acid
KP728_22125	COG0531	amino acid
KP728_22135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KP728_22140	COG0277	FAD linked oxidase domain protein
KP728_22160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KP728_22200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KP728_22205	COG2258	MOSC domain
KP728_22220	COG0505	Belongs to the CarA family
KP728_22230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KP728_22235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KP728_22245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KP728_22270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KP728_22280	COG2205	protein histidine kinase activity
KP728_22280	COG2198	Histidine kinase
KP728_22280	COG0784	Response regulator, receiver
KP728_22285	COG1024	Enoyl-CoA hydratase
KP728_22295	COG0318	PFAM AMP-dependent synthetase and ligase
KP728_22325	COG2267	carboxylic ester hydrolase activity
KP728_22355	COG0840	transmembrane signaling receptor activity
KP728_22365	COG0835	chemotaxis
KP728_22380	COG0840	transmembrane signaling receptor activity
KP728_22385	COG0840	transmembrane signaling receptor activity
KP728_22390	COG0840	transmembrane signaling receptor activity
KP728_22395	COG0840	transmembrane signaling receptor activity
KP728_22405	COG0840	transmembrane signaling receptor activity
KP728_22410	COG0840	transmembrane signaling receptor activity