locus-tag	class	description
F6Y24_00010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F6Y24_00015	COG2258	MOSC domain
F6Y24_00025	COG0505	Belongs to the CarA family
F6Y24_00035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F6Y24_00040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F6Y24_00050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F6Y24_00065	COG3279	Response regulator of the LytR AlgR family
F6Y24_00075	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F6Y24_00085	COG2205	protein histidine kinase activity
F6Y24_00085	COG2198	Histidine kinase
F6Y24_00085	COG0784	Response regulator, receiver
F6Y24_00090	COG1024	Enoyl-CoA hydratase
F6Y24_00095	COG0318	PFAM AMP-dependent synthetase and ligase
F6Y24_00125	COG2267	carboxylic ester hydrolase activity
F6Y24_00140	COG2201	protein-glutamate methylesterase activity
F6Y24_00155	COG0840	transmembrane signaling receptor activity
F6Y24_00165	COG0835	chemotaxis
F6Y24_00195	COG0840	transmembrane signaling receptor activity
F6Y24_00200	COG0840	transmembrane signaling receptor activity
F6Y24_00205	COG0840	transmembrane signaling receptor activity
F6Y24_00210	COG0840	transmembrane signaling receptor activity
F6Y24_00215	COG0840	transmembrane signaling receptor activity
F6Y24_00220	COG0840	transmembrane signaling receptor activity
F6Y24_00230	COG0840	transmembrane signaling receptor activity
F6Y24_00235	COG0840	transmembrane signaling receptor activity
F6Y24_00245	COG0840	transmembrane signaling receptor activity
F6Y24_00255	COG0745	RESPONSE REGULATOR receiver
F6Y24_00265	COG0835	chemotaxis
F6Y24_00270	COG1192	Involved in chromosome partitioning
F6Y24_00275	COG1360	Flagellar Motor Protein
F6Y24_00280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F6Y24_00385	COG2198	Histidine kinase
F6Y24_00385	COG0643	Histidine kinase
F6Y24_00405	COG0455	bacterial-type flagellum organization
F6Y24_00435	COG5001	Diguanylate cyclase
F6Y24_00435	COG3300	MHYT domain
F6Y24_00440	COG1684	flagellar biosynthetic protein fliR
F6Y24_00445	COG1987	bacterial-type flagellum assembly
F6Y24_00505	COG1677	Flagellar hook-basal body complex protein FliE
F6Y24_00540	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_00550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F6Y24_00565	COG3604	Transcriptional regulator
F6Y24_00570	COG2201	protein-glutamate methylesterase activity
F6Y24_00600	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
F6Y24_00605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F6Y24_00610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F6Y24_00620	COG1705	Flagellar rod assembly protein muramidase FlgJ
F6Y24_00620	COG3951	Flagellar rod assembly protein muramidase FlgJ
F6Y24_00625	COG1706	bacterial-type flagellum-dependent cell motility
F6Y24_00630	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F6Y24_00635	COG4786	Flagellar basal body rod
F6Y24_00650	COG4787	bacterial-type flagellum-dependent cell motility
F6Y24_00655	COG1749	Flagellar hook protein flgE
F6Y24_00660	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
F6Y24_00665	COG1558	bacterial-type flagellum-dependent cell motility
F6Y24_00670	COG1815	bacterial-type flagellum-dependent cell motility
F6Y24_00675	COG0835	chemotaxis
F6Y24_00675	COG0784	Response regulator, receiver
F6Y24_00695	COG4191	Histidine kinase
F6Y24_00725	COG2915	High frequency lysogenization protein hflD homolog
F6Y24_00730	COG0482	sulfurtransferase activity
F6Y24_00745	COG0542	response to heat
F6Y24_00750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F6Y24_00755	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
F6Y24_00765	COG0492	ferredoxin-NADP+ reductase activity
F6Y24_00770	COG1674	ftsk spoiiie
F6Y24_00790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F6Y24_00795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F6Y24_00800	COG0183	Belongs to the thiolase family
F6Y24_00805	COG1024	Enoyl-CoA hydratase
F6Y24_00805	COG1250	3-hydroxyacyl-CoA dehydrogenase
F6Y24_00815	COG0105	UTP biosynthetic process
F6Y24_00820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F6Y24_00830	COG1426	Protein conserved in bacteria
F6Y24_00840	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F6Y24_00845	COG1160	GTP binding
F6Y24_00850	COG0303	'Molybdopterin
F6Y24_00855	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F6Y24_00880	COG0708	Exodeoxyribonuclease III
F6Y24_00890	COG0303	'Molybdopterin
F6Y24_00895	COG0746	molybdenum cofactor guanylyltransferase activity
F6Y24_00905	COG1648	precorrin-2 dehydrogenase activity
F6Y24_00905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F6Y24_00930	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
F6Y24_00945	COG0579	oxidoreductase
F6Y24_00965	COG5001	Diguanylate cyclase
F6Y24_01020	COG0784	Response regulator, receiver
F6Y24_01020	COG4191	Histidine kinase
F6Y24_01080	COG0840	transmembrane signaling receptor activity
F6Y24_01110	COG3781	membrane
F6Y24_01120	COG2197	response regulator
F6Y24_01135	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_01145	COG4771	TonB-dependent receptor
F6Y24_01355	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F6Y24_01375	COG4644	lycopene metabolic process
F6Y24_01380	COG2951	lytic endotransglycosylase activity
F6Y24_01405	COG2154	pterin-4-alpha-carbinolamine dehydratase
F6Y24_01415	COG0428	transporter
F6Y24_01425	COG1530	ribonuclease E activity
F6Y24_01455	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F6Y24_01480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F6Y24_01485	COG0322	excinuclease ABC activity
F6Y24_01495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F6Y24_01500	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F6Y24_01510	COG1663	tetraacyldisaccharide 4'-kinase activity
F6Y24_01515	COG1132	(ABC) transporter
F6Y24_01520	COG0848	biopolymer transport protein
F6Y24_01525	COG0811	peptide transport
F6Y24_01545	COG4591	ABC-type transport system involved in lipoprotein release permease component
F6Y24_01555	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F6Y24_01560	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F6Y24_01575	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
F6Y24_01580	COG2009	succinate dehydrogenase
F6Y24_01600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F6Y24_01605	COG0837	glucose binding
F6Y24_01615	COG0129	dihydroxy-acid dehydratase activity
F6Y24_01620	COG0800	Aldolase
F6Y24_01745	COG5002	protein histidine kinase activity
F6Y24_01745	COG2205	protein histidine kinase activity
F6Y24_01745	COG0784	Response regulator, receiver
F6Y24_01750	COG2183	response to ionizing radiation
F6Y24_01760	COG0723	plastoquinol--plastocyanin reductase activity
F6Y24_01760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F6Y24_01775	COG3243	poly(R)-hydroxyalkanoic acid synthase
F6Y24_01785	COG1183	phosphatidylcholine synthase activity
F6Y24_01790	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_01815	COG0668	transmembrane transport
F6Y24_01820	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F6Y24_01825	COG0590	tRNA wobble adenosine to inosine editing
F6Y24_01830	COG1321	iron dependent repressor
F6Y24_01835	COG1914	H( )-stimulated, divalent metal cation uptake system
F6Y24_01860	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_01910	COG0582	viral genome integration into host DNA
F6Y24_01930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F6Y24_01945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F6Y24_01960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
F6Y24_01975	COG0539	negative regulation of cytoplasmic translation
F6Y24_01980	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F6Y24_01985	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F6Y24_01995	COG2957	Belongs to the agmatine deiminase family
F6Y24_02000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F6Y24_02025	COG0395	ABC-type sugar transport system, permease component
F6Y24_02030	COG1175	transmembrane transport
F6Y24_02050	COG1609	Transcriptional regulator
F6Y24_02060	COG2350	Protein conserved in bacteria
F6Y24_02065	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F6Y24_02070	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F6Y24_02075	COG1187	pseudouridine synthase activity
F6Y24_02095	COG0436	Aminotransferase
F6Y24_02100	COG4133	protoheme IX ABC transporter activity
F6Y24_02120	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
F6Y24_02150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F6Y24_02160	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F6Y24_02165	COG4988	ABC transporter
F6Y24_02175	COG1294	oxidase, subunit
F6Y24_02220	COG0165	Argininosuccinate lyase
F6Y24_02235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F6Y24_02250	COG0137	argininosuccinate synthase activity
F6Y24_02255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F6Y24_02265	COG0215	cysteine-tRNA ligase activity
F6Y24_02270	COG2166	iron-sulfur cluster assembly
F6Y24_02280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F6Y24_02290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F6Y24_02305	COG4303	Ethanolamine ammonia lyase large subunit
F6Y24_02310	COG4302	ethanolamine ammonia-lyase activity
F6Y24_02355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F6Y24_02360	COG0402	S-adenosylhomocysteine deaminase activity
F6Y24_02370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F6Y24_02380	COG5001	Diguanylate cyclase
F6Y24_02380	COG3300	MHYT domain
F6Y24_02395	COG0483	inositol monophosphate 1-phosphatase activity
F6Y24_02420	COG0513	Belongs to the DEAD box helicase family
F6Y24_02425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F6Y24_02430	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F6Y24_02440	COG0625	glutathione transferase activity
F6Y24_02455	COG4681	YaeQ
F6Y24_02475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F6Y24_02480	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_02500	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F6Y24_02505	COG0860	N-Acetylmuramoyl-L-alanine amidase
F6Y24_02515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F6Y24_02515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F6Y24_02520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F6Y24_02535	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F6Y24_02560	COG2199	diguanylate cyclase activity
F6Y24_02565	COG0835	chemotaxis
F6Y24_02570	COG0840	transmembrane signaling receptor activity
F6Y24_02575	COG2094	Belongs to the DNA glycosylase MPG family
F6Y24_02580	COG1201	RNA secondary structure unwinding
F6Y24_02590	COG2969	positive regulation of protein catabolic process
F6Y24_02595	COG0625	glutathione transferase activity
F6Y24_02600	COG2857	Cytochrome c1
F6Y24_02605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F6Y24_02610	COG0723	plastoquinol--plastocyanin reductase activity
F6Y24_02615	COG0741	lytic transglycosylase activity
F6Y24_02635	COG1702	phosphate starvation-inducible protein PhoH
F6Y24_02645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F6Y24_02655	COG4535	Mg2 and Co2 transporter CorC
F6Y24_02670	COG1012	belongs to the aldehyde dehydrogenase family
F6Y24_02680	COG1177	transmembrane transport
F6Y24_02685	COG1176	ABC-type spermidine putrescine transport system, permease component I
F6Y24_02690	COG3842	ATPase activity
F6Y24_02710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F6Y24_02720	COG0174	glutamine synthetase
F6Y24_02725	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F6Y24_02730	COG0174	glutamine synthetase
F6Y24_02735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F6Y24_02740	COG3706	GGDEF domain
F6Y24_02740	COG0745	RESPONSE REGULATOR receiver
F6Y24_02745	COG2703	oxygen carrier activity
F6Y24_02750	COG0477	Major facilitator Superfamily
F6Y24_02765	COG0243	molybdopterin cofactor binding
F6Y24_02790	COG2733	membrane
F6Y24_02795	COG0784	Response regulator, receiver
F6Y24_02795	COG2205	protein histidine kinase activity
F6Y24_02795	COG5002	protein histidine kinase activity
F6Y24_02805	COG0477	Major facilitator Superfamily
F6Y24_02815	COG0604	alcohol dehydrogenase
F6Y24_02820	COG0300	oxidoreductase activity
F6Y24_02845	COG2902	Dehydrogenase
F6Y24_02855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6Y24_02860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F6Y24_02875	COG1609	Transcriptional regulator
F6Y24_02880	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6Y24_02880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F6Y24_02885	COG1105	Belongs to the carbohydrate kinase PfkB family
F6Y24_02890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F6Y24_02890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F6Y24_02900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F6Y24_02910	COG1862	Preprotein translocase
F6Y24_02920	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F6Y24_02955	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F6Y24_02960	COG3291	Pkd domain containing protein
F6Y24_02970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F6Y24_02990	COG0742	ribosomal rna small subunit methyltransferase
F6Y24_02995	COG0326	Molecular chaperone. Has ATPase activity
F6Y24_03005	COG4206	TonB-dependent receptor
F6Y24_03090	COG0531	amino acid
F6Y24_03105	COG0006	proline dipeptidase activity
F6Y24_03115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F6Y24_03130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F6Y24_03135	COG3938	Belongs to the proline racemase family
F6Y24_03145	COG0552	protein localization to endoplasmic reticulum
F6Y24_03155	COG1194	a g-specific adenine glycosylase
F6Y24_03165	COG0784	Response regulator, receiver
F6Y24_03165	COG4191	Histidine kinase
F6Y24_03175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F6Y24_03205	COG1960	acyl-CoA dehydrogenase activity
F6Y24_03215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F6Y24_03235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F6Y24_03240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F6Y24_03245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F6Y24_03280	COG0438	transferase activity, transferring glycosyl groups
F6Y24_03285	COG0438	transferase activity, transferring glycosyl groups
F6Y24_03330	COG0776	regulation of translation
F6Y24_03335	COG0072	phenylalanine-tRNA ligase activity
F6Y24_03335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F6Y24_03340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F6Y24_03345	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F6Y24_03350	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F6Y24_03355	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F6Y24_03360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F6Y24_03375	COG2211	Major facilitator Superfamily
F6Y24_03375	COG2190	(PTS) system
F6Y24_03385	COG1082	Xylose isomerase domain protein TIM barrel
F6Y24_03445	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F6Y24_03520	COG3702	type iv secretory pathway
F6Y24_03540	COG2948	multi-organism process
F6Y24_03560	COG3505	Type IV secretory pathway VirD4
F6Y24_03575	COG0556	nucleotide-excision repair
F6Y24_03770	COG3179	chitinase
F6Y24_03815	COG4695	Portal protein
F6Y24_03910	COG3275	phosphorelay sensor kinase activity
F6Y24_03915	COG1611	Belongs to the LOG family
F6Y24_03925	COG2095	MarC family integral membrane protein
F6Y24_03930	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_03935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F6Y24_03940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F6Y24_03975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F6Y24_03980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F6Y24_03985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F6Y24_03990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F6Y24_03995	COG0195	Participates in both transcription termination and antitermination
F6Y24_04000	COG0779	Required for maturation of 30S ribosomal subunits
F6Y24_04010	COG1007	ATP synthesis coupled electron transport
F6Y24_04025	COG0713	ATP synthesis coupled electron transport
F6Y24_04030	COG0839	Belongs to the complex I subunit 6 family
F6Y24_04035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F6Y24_04040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F6Y24_04050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F6Y24_04055	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
F6Y24_04065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F6Y24_04075	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F6Y24_04095	COG4221	oxidoreductase activity
F6Y24_04125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F6Y24_04135	COG0159	tryptophan synthase activity
F6Y24_04145	COG0133	tryptophan synthase activity
F6Y24_04155	COG0135	phosphoribosylanthranilate isomerase activity
F6Y24_04175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F6Y24_04180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F6Y24_04195	COG2890	protein-(glutamine-N5) methyltransferase activity
F6Y24_04205	COG0688	phosphatidylethanolamine metabolic process
F6Y24_04220	COG0433	COG0433 Predicted ATPase
F6Y24_04225	COG0494	nUDIX hydrolase
F6Y24_04240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F6Y24_04245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F6Y24_04285	COG3706	GGDEF domain
F6Y24_04295	COG3706	GGDEF domain
F6Y24_04320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6Y24_04335	COG0583	DNA-binding transcription factor activity
F6Y24_04350	COG0415	Belongs to the DNA photolyase family
F6Y24_04355	COG0305	Participates in initiation and elongation during chromosome replication
F6Y24_04365	COG0367	asparagine synthase
F6Y24_04380	COG1960	acyl-CoA dehydrogenase activity
F6Y24_04395	COG0084	hydrolase, TatD family'
F6Y24_04400	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F6Y24_04460	COG0386	Belongs to the glutathione peroxidase family
F6Y24_04470	COG0339	signal peptide processing
F6Y24_04530	COG2814	Major facilitator Superfamily
F6Y24_04535	COG1566	PFAM secretion protein HlyD family protein
F6Y24_04580	COG4774	siderophore transport
F6Y24_04590	COG0367	asparagine synthase
F6Y24_04595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F6Y24_04600	COG1393	Belongs to the ArsC family
F6Y24_04620	COG0024	Methionine aminopeptidase
F6Y24_04660	COG0052	Belongs to the universal ribosomal protein uS2 family
F6Y24_04665	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F6Y24_04670	COG0745	RESPONSE REGULATOR receiver
F6Y24_04670	COG3706	GGDEF domain
F6Y24_04675	COG0528	UMP kinase activity
F6Y24_04690	COG0575	Belongs to the CDS family
F6Y24_04695	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F6Y24_04700	COG0750	zinc metalloprotease
F6Y24_04715	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F6Y24_04725	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F6Y24_04730	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F6Y24_04745	COG0825	malonyl-CoA metabolic process
F6Y24_04780	COG1695	Transcriptional regulator
F6Y24_04800	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F6Y24_04820	COG2040	homocysteine
F6Y24_04825	COG0833	amino acid
F6Y24_04845	COG0346	lactoylglutathione lyase activity
F6Y24_04865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F6Y24_04865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F6Y24_04875	COG2878	Part of a membrane complex involved in electron transport
F6Y24_04890	COG1595	DNA-templated transcription, initiation
F6Y24_04915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F6Y24_04930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F6Y24_04935	COG0251	oxidation-reduction process
F6Y24_04945	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F6Y24_04945	COG0392	lysyltransferase activity
F6Y24_04985	COG2814	Major facilitator Superfamily
F6Y24_04990	COG1902	pentaerythritol trinitrate reductase activity
F6Y24_05010	COG2824	Alkylphosphonate utilization operon protein PhnA
F6Y24_05020	COG1047	Peptidyl-prolyl cis-trans
F6Y24_05065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F6Y24_05075	COG5487	UPF0391 membrane protein
F6Y24_05080	COG1451	nucleotide metabolic process
F6Y24_05100	COG0183	Belongs to the thiolase family
F6Y24_05130	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F6Y24_05130	COG1793	dna ligase
F6Y24_05140	COG1793	dna ligase
F6Y24_05145	COG1201	RNA secondary structure unwinding
F6Y24_05155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F6Y24_05160	COG1278	Cold shock
F6Y24_05165	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F6Y24_05175	COG1472	Belongs to the glycosyl hydrolase 3 family
F6Y24_05180	COG3046	protein related to deoxyribodipyrimidine photolyase
F6Y24_05185	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
F6Y24_05190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F6Y24_05210	COG1381	Involved in DNA repair and RecF pathway recombination
F6Y24_05215	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F6Y24_05220	COG0571	ribonuclease III activity
F6Y24_05240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F6Y24_05280	COG1960	acyl-CoA dehydrogenase activity
F6Y24_05290	COG3800	Transcriptional regulator
F6Y24_05290	COG1396	sequence-specific DNA binding
F6Y24_05300	COG3867	Arabinogalactan endo-beta-1,4-galactanase
F6Y24_05305	COG3250	beta-galactosidase activity
F6Y24_05350	COG0322	excinuclease ABC activity
F6Y24_05370	COG2003	Belongs to the UPF0758 family
F6Y24_05395	COG2814	Major facilitator Superfamily
F6Y24_05400	COG1733	regulation of RNA biosynthetic process
F6Y24_05420	COG0840	transmembrane signaling receptor activity
F6Y24_05530	COG0210	DNA helicase
F6Y24_05565	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F6Y24_05585	COG0336	Belongs to the RNA methyltransferase TrmD family
F6Y24_05605	COG2070	2-Nitropropane dioxygenase
F6Y24_05610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F6Y24_05625	COG3534	alpha-L-arabinofuranosidase
F6Y24_05655	COG4191	Histidine kinase
F6Y24_05655	COG0784	Response regulator, receiver
F6Y24_05660	COG4999	Histidine kinase
F6Y24_05660	COG2205	protein histidine kinase activity
F6Y24_05660	COG3437	response regulator, receiver
F6Y24_05660	COG3850	Histidine kinase
F6Y24_05665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F6Y24_05675	COG2205	protein histidine kinase activity
F6Y24_05680	COG5507	3-demethylubiquinone-9 3-methyltransferase
F6Y24_05690	COG4771	TonB-dependent receptor
F6Y24_05720	COG2172	sigma factor antagonist activity
F6Y24_05725	COG1366	Belongs to the anti-sigma-factor antagonist family
F6Y24_05730	COG1366	Belongs to the anti-sigma-factor antagonist family
F6Y24_05735	COG1902	pentaerythritol trinitrate reductase activity
F6Y24_05750	COG0326	Molecular chaperone. Has ATPase activity
F6Y24_05755	COG2207	Transcriptional regulator
F6Y24_05765	COG3152	Membrane
F6Y24_05780	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F6Y24_05785	COG1845	cytochrome c oxidase, subunit III
F6Y24_05790	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F6Y24_05805	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F6Y24_05810	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F6Y24_05820	COG0196	riboflavin kinase activity
F6Y24_05825	COG0728	peptidoglycan biosynthetic process
F6Y24_05850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F6Y24_05855	COG0824	Thioesterase
F6Y24_05865	COG1024	Enoyl-CoA hydratase
F6Y24_05870	COG1946	Acyl-CoA thioesterase
F6Y24_05880	COG1595	DNA-templated transcription, initiation
F6Y24_05890	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
F6Y24_05925	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
F6Y24_05940	COG2197	response regulator
F6Y24_05945	COG4585	Histidine kinase
F6Y24_05960	COG2894	cell division
F6Y24_05965	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F6Y24_05980	COG5002	protein histidine kinase activity
F6Y24_05985	COG0745	RESPONSE REGULATOR receiver
F6Y24_05990	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F6Y24_06000	COG2194	sulfuric ester hydrolase activity
F6Y24_06035	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F6Y24_06035	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F6Y24_06040	COG2272	Belongs to the type-B carboxylesterase lipase family
F6Y24_06045	COG0656	L-ascorbic acid biosynthetic process
F6Y24_06050	COG0753	catalase activity
F6Y24_06085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6Y24_06090	COG2207	Transcriptional regulator
F6Y24_06090	COG1917	Cupin 2, conserved barrel domain protein
F6Y24_06105	COG1506	peptidase
F6Y24_06105	COG0823	Involved in the tonB-independent uptake of proteins
F6Y24_06125	COG1297	OPT oligopeptide transporter protein
F6Y24_06135	COG0587	DNA-directed DNA polymerase activity
F6Y24_06195	COG2080	2 iron, 2 sulfur cluster binding
F6Y24_06200	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F6Y24_06205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F6Y24_06230	COG2271	Major facilitator Superfamily
F6Y24_06245	COG2323	membrane
F6Y24_06290	COG3537	Alpha-1,2-mannosidase
F6Y24_06300	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_06315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F6Y24_06320	COG0328	RNA-DNA hybrid ribonuclease activity
F6Y24_06320	COG0406	alpha-ribazole phosphatase activity
F6Y24_06325	COG1309	transcriptional regulator
F6Y24_06380	COG1309	transcriptional regulator
F6Y24_06405	COG0308	aminopeptidase N
F6Y24_06410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F6Y24_06425	COG0330	HflC and HflK could
F6Y24_06430	COG0330	HflC and HflK could
F6Y24_06450	COG0678	peroxiredoxin activity
F6Y24_06460	COG4953	penicillin-binding protein 1C
F6Y24_06545	COG3829	transcription factor binding
F6Y24_06570	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F6Y24_06575	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F6Y24_06585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F6Y24_06590	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_06595	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F6Y24_06605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F6Y24_06610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F6Y24_06615	COG1399	metal-binding, possibly nucleic acid-binding protein
F6Y24_06620	COG0424	maF-like protein
F6Y24_06640	COG0714	Associated with various cellular activities
F6Y24_06660	COG0537	adenosine 5'-monophosphoramidase activity
F6Y24_06665	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F6Y24_06670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F6Y24_06690	COG0314	molybdopterin synthase activity
F6Y24_06695	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F6Y24_06705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F6Y24_06710	COG1234	tRNA 3'-trailer cleavage
F6Y24_06720	COG0859	PFAM glycosyl transferase family 9
F6Y24_06735	COG0631	protein serine/threonine phosphatase activity
F6Y24_06745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F6Y24_06760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F6Y24_06770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F6Y24_06800	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F6Y24_06805	COG0740	serine-type endopeptidase activity
F6Y24_06810	COG0544	peptidyl-prolyl cis-trans isomerase activity
F6Y24_06820	COG4191	Histidine kinase
F6Y24_06820	COG0784	Response regulator, receiver
F6Y24_06855	COG0473	3-isopropylmalate dehydrogenase activity
F6Y24_06870	COG4783	chaperone-mediated protein folding
F6Y24_06885	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F6Y24_06895	COG0438	transferase activity, transferring glycosyl groups
F6Y24_06900	COG0671	phosphoesterase, PA-phosphatase related
F6Y24_06905	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F6Y24_06915	COG3291	Pkd domain containing protein
F6Y24_06920	COG2833	Protein of unknown function (DUF455)
F6Y24_06940	COG0285	dihydrofolate synthase activity
F6Y24_06950	COG0406	alpha-ribazole phosphatase activity
F6Y24_06970	COG1063	alcohol dehydrogenase
F6Y24_06980	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F6Y24_06985	COG4208	sulfate ABC transporter
F6Y24_06990	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
F6Y24_06995	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F6Y24_07020	COG2885	chlorophyll binding
F6Y24_07025	COG0604	alcohol dehydrogenase
F6Y24_07030	COG0446	pyridine nucleotide-disulphide oxidoreductase
F6Y24_07030	COG1902	pentaerythritol trinitrate reductase activity
F6Y24_07045	COG0625	glutathione transferase activity
F6Y24_07055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F6Y24_07070	COG0154	amidase activity
F6Y24_07080	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F6Y24_07090	COG0203	ribosomal protein L17
F6Y24_07095	COG0202	RNA polymerase activity
F6Y24_07100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F6Y24_07105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F6Y24_07110	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F6Y24_07115	COG0201	protein transport
F6Y24_07125	COG1841	ribosomal large subunit assembly
F6Y24_07130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F6Y24_07140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F6Y24_07150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F6Y24_07160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F6Y24_07165	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F6Y24_07175	COG0255	Belongs to the universal ribosomal protein uL29 family
F6Y24_07200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F6Y24_07220	COG0051	transcription antitermination factor activity, RNA binding
F6Y24_07225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F6Y24_07230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F6Y24_07240	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F6Y24_07245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F6Y24_07255	COG0222	ribosome binding
F6Y24_07260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F6Y24_07265	COG0081	regulation of translation
F6Y24_07270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F6Y24_07275	COG0250	Participates in transcription elongation, termination and antitermination
F6Y24_07280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F6Y24_07290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F6Y24_07310	COG0012	GTP binding
F6Y24_07315	COG0193	aminoacyl-tRNA hydrolase activity
F6Y24_07320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F6Y24_07325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F6Y24_07340	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
F6Y24_07350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F6Y24_07365	COG0521	Mo-molybdopterin cofactor biosynthetic process
F6Y24_07380	COG1254	Belongs to the acylphosphatase family
F6Y24_07385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F6Y24_07390	COG1295	ribonuclease BN
F6Y24_07410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F6Y24_07415	COG1404	Belongs to the peptidase S8 family
F6Y24_07425	COG1404	Belongs to the peptidase S8 family
F6Y24_07430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F6Y24_07450	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F6Y24_07455	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F6Y24_07475	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F6Y24_07505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F6Y24_07505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F6Y24_07525	COG2890	protein-(glutamine-N5) methyltransferase activity
F6Y24_07535	COG3634	alkyl hydroperoxide reductase activity
F6Y24_07540	COG0583	DNA-binding transcription factor activity
F6Y24_07545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F6Y24_07550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F6Y24_07560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F6Y24_07570	COG2197	response regulator
F6Y24_07580	COG0745	RESPONSE REGULATOR receiver
F6Y24_07580	COG3706	GGDEF domain
F6Y24_07595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F6Y24_07600	COG0697	spore germination
F6Y24_07650	COG1024	Enoyl-CoA hydratase
F6Y24_07660	COG0318	PFAM AMP-dependent synthetase and ligase
F6Y24_07665	COG0583	DNA-binding transcription factor activity
F6Y24_07670	COG3384	dioxygenase
F6Y24_07700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F6Y24_07705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F6Y24_07715	COG2096	Adenosyltransferase
F6Y24_07720	COG0123	including yeast histone deacetylase and acetoin utilization protein
F6Y24_07725	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F6Y24_07735	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F6Y24_07745	COG2967	ApaG domain
F6Y24_07750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F6Y24_07760	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F6Y24_07765	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F6Y24_07785	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F6Y24_07795	COG0642	Histidine kinase
F6Y24_07810	COG4181	ATPase activity
F6Y24_07830	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
F6Y24_07835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6Y24_07855	COG4771	TonB-dependent receptor
F6Y24_07865	COG0667	Aldo Keto reductase
F6Y24_07870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F6Y24_07885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F6Y24_07890	COG4106	trans-aconitate 2-methyltransferase activity
F6Y24_07905	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F6Y24_07920	COG2885	chlorophyll binding
F6Y24_07940	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F6Y24_07955	COG2226	methyltransferase
F6Y24_07980	COG0366	Alpha amylase catalytic
F6Y24_08000	COG3321	synthase
F6Y24_08000	COG0604	alcohol dehydrogenase
F6Y24_08000	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_08005	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F6Y24_08020	COG0494	nUDIX hydrolase
F6Y24_08030	COG0653	protein targeting
F6Y24_08035	COG0739	heme binding
F6Y24_08060	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F6Y24_08065	COG1181	Belongs to the D-alanine--D-alanine ligase family
F6Y24_08070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F6Y24_08090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F6Y24_08095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F6Y24_08105	COG3116	cell division
F6Y24_08145	COG1988	membrane-bound metal-dependent
F6Y24_08150	COG0277	FAD linked oxidase domain protein
F6Y24_08155	COG0823	Involved in the tonB-independent uptake of proteins
F6Y24_08155	COG4946	Tricorn protease homolog
F6Y24_08155	COG1506	peptidase
F6Y24_08160	COG0745	RESPONSE REGULATOR receiver
F6Y24_08165	COG2205	protein histidine kinase activity
F6Y24_08170	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F6Y24_08175	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F6Y24_08180	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F6Y24_08205	COG0697	spore germination
F6Y24_08215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F6Y24_08225	COG3791	Glutathione-dependent formaldehyde-activating
F6Y24_08240	COG3920	Histidine kinase
F6Y24_08255	COG0745	RESPONSE REGULATOR receiver
F6Y24_08260	COG2205	protein histidine kinase activity
F6Y24_08275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F6Y24_08280	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F6Y24_08295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F6Y24_08305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F6Y24_08310	COG1012	belongs to the aldehyde dehydrogenase family
F6Y24_08315	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F6Y24_08345	COG0617	tRNA 3'-terminal CCA addition
F6Y24_08360	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F6Y24_08365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F6Y24_08370	COG1609	Transcriptional regulator
F6Y24_08395	COG3250	beta-galactosidase activity
F6Y24_08445	COG1459	type II secretion system
F6Y24_08490	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_08495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F6Y24_08500	COG4191	Histidine kinase
F6Y24_08505	COG0784	Response regulator, receiver
F6Y24_08510	COG4251	negative regulation of phosphorylation
F6Y24_08515	COG2823	Periplasmic or secreted lipoprotein
F6Y24_08520	COG0673	inositol 2-dehydrogenase activity
F6Y24_08525	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F6Y24_08545	COG2813	Specifically methylates the guanine in position
F6Y24_08560	COG1051	belongs to the nudix hydrolase family
F6Y24_08560	COG1056	cytidyltransferase-related domain
F6Y24_08585	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F6Y24_08590	COG0321	lipoyl(octanoyl) transferase activity
F6Y24_08610	COG1686	Belongs to the peptidase S11 family
F6Y24_08615	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F6Y24_08620	COG2951	lytic endotransglycosylase activity
F6Y24_08630	COG0772	Belongs to the SEDS family
F6Y24_08645	COG1792	Involved in formation and maintenance of cell shape
F6Y24_08655	COG1077	Cell shape determining protein MreB Mrl
F6Y24_08665	COG3284	Transcriptional regulator
F6Y24_08680	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
F6Y24_08715	COG0308	aminopeptidase N
F6Y24_08720	COG5001	Diguanylate cyclase
F6Y24_08720	COG3300	MHYT domain
F6Y24_08725	COG2226	methyltransferase
F6Y24_08760	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F6Y24_08775	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F6Y24_08785	COG2832	Protein of unknown function (DUF454)
F6Y24_08800	COG1505	serine-type exopeptidase activity
F6Y24_08825	COG0181	hydroxymethylbilane synthase activity
F6Y24_08835	COG3275	phosphorelay sensor kinase activity
F6Y24_08845	COG2943	transferase activity, transferring hexosyl groups
F6Y24_08855	COG3706	GGDEF domain
F6Y24_08860	COG0659	secondary active sulfate transmembrane transporter activity
F6Y24_08865	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
F6Y24_08865	COG5297	Belongs to the glycosyl hydrolase family 6
F6Y24_08870	COG0840	transmembrane signaling receptor activity
F6Y24_08935	COG0598	Magnesium transport protein CorA
F6Y24_08945	COG1113	amino acid transport
F6Y24_08965	COG0697	spore germination
F6Y24_09000	COG3706	GGDEF domain
F6Y24_09015	COG0823	Involved in the tonB-independent uptake of proteins
F6Y24_09015	COG1506	peptidase
F6Y24_09050	COG0435	Glutathione S-transferase
F6Y24_09110	COG4206	TonB-dependent receptor
F6Y24_09120	COG1595	DNA-templated transcription, initiation
F6Y24_09225	COG0546	phosphoglycolate phosphatase activity
F6Y24_09230	COG1802	Transcriptional regulator
F6Y24_09265	COG3052	prosthetic group binding
F6Y24_09285	COG2353	YceI-like domain
F6Y24_09290	COG0778	Nitroreductase
F6Y24_09315	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F6Y24_09340	COG3712	iron ion homeostasis
F6Y24_09365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F6Y24_09390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F6Y24_09395	COG2356	endonuclease I
F6Y24_09400	COG1324	tolerance protein
F6Y24_09415	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F6Y24_09420	COG0511	ligase activity, forming carbon-carbon bonds
F6Y24_09430	COG0439	Biotin carboxylase
F6Y24_09445	COG2264	protein methyltransferase activity
F6Y24_09465	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
F6Y24_09485	COG0138	bifunctional purine biosynthesis protein purh
F6Y24_09490	COG0151	Belongs to the GarS family
F6Y24_09495	COG1289	transmembrane transporter activity
F6Y24_09500	COG2814	Major facilitator Superfamily
F6Y24_09525	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F6Y24_09540	COG0316	Belongs to the HesB IscA family
F6Y24_09585	COG1051	belongs to the nudix hydrolase family
F6Y24_09600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F6Y24_09605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F6Y24_09610	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
F6Y24_09625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F6Y24_09635	COG0134	indole-3-glycerol-phosphate synthase activity
F6Y24_09640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F6Y24_09730	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F6Y24_09810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F6Y24_09830	COG0583	DNA-binding transcription factor activity
F6Y24_09850	COG1597	lipid kinase activity
F6Y24_09870	COG0484	heat shock protein binding
F6Y24_09915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F6Y24_09915	COG2111	Na H antiporter
F6Y24_09920	COG1006	Multisubunit Na H antiporter MnhC subunit
F6Y24_09925	COG0651	ATP synthesis coupled electron transport
F6Y24_09935	COG2212	antiporter activity
F6Y24_09940	COG1320	monovalent cation:proton antiporter activity
F6Y24_09955	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
F6Y24_09975	COG3104	oligopeptide transport
F6Y24_09990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F6Y24_10005	COG0508	dehydrogenase complex catalyzes the overall conversion of
F6Y24_10020	COG0513	Belongs to the DEAD box helicase family
F6Y24_10035	COG4221	oxidoreductase activity
F6Y24_10040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F6Y24_10080	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_10085	COG0702	epimerase
F6Y24_10110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F6Y24_10115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F6Y24_10120	COG0297	glycogen (starch) synthase activity
F6Y24_10125	COG3706	GGDEF domain
F6Y24_10125	COG0745	RESPONSE REGULATOR receiver
F6Y24_10130	COG2354	Protein conserved in bacteria
F6Y24_10135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F6Y24_10140	COG1368	sulfuric ester hydrolase activity
F6Y24_10150	COG1511	domain protein
F6Y24_10150	COG3264	Mechanosensitive ion channel
F6Y24_10180	COG1132	(ABC) transporter
F6Y24_10190	COG4771	TonB-dependent receptor
F6Y24_10205	COG3433	isochorismatase activity
F6Y24_10205	COG2226	methyltransferase
F6Y24_10205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F6Y24_10225	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
F6Y24_10230	COG1021	2,3-dihydroxybenzoate-AMP ligase
F6Y24_10240	COG1131	(ABC) transporter
F6Y24_10250	COG4771	TonB-dependent receptor
F6Y24_10315	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F6Y24_10320	COG1040	competence protein
F6Y24_10325	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F6Y24_10330	COG0156	8-amino-7-oxononanoate synthase activity
F6Y24_10375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F6Y24_10385	COG0445	tRNA wobble uridine modification
F6Y24_10410	COG1414	Transcriptional regulator
F6Y24_10420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F6Y24_10435	COG3485	protocatechuate 3,4-dioxygenase
F6Y24_10440	COG3485	protocatechuate 3,4-dioxygenase
F6Y24_10450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F6Y24_10455	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F6Y24_10485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F6Y24_10540	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F6Y24_10560	COG0129	dihydroxy-acid dehydratase activity
F6Y24_10620	COG1733	regulation of RNA biosynthetic process
F6Y24_10625	COG0702	epimerase
F6Y24_10635	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F6Y24_10650	COG0583	DNA-binding transcription factor activity
F6Y24_10655	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F6Y24_10660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F6Y24_10710	COG0577	efflux transmembrane transporter activity
F6Y24_10725	COG1538	Outer membrane efflux protein
F6Y24_10735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6Y24_10740	COG2205	protein histidine kinase activity
F6Y24_10750	COG0745	RESPONSE REGULATOR receiver
F6Y24_10755	COG2223	nitrite transmembrane transporter activity
F6Y24_10775	COG1902	pentaerythritol trinitrate reductase activity
F6Y24_10780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F6Y24_10800	COG1404	Belongs to the peptidase S8 family
F6Y24_10805	COG2814	Major facilitator Superfamily
F6Y24_10835	COG0084	hydrolase, TatD family'
F6Y24_10860	COG1957	nucleoside hydrolase
F6Y24_10910	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F6Y24_10930	COG2072	flavoprotein involved in K transport
F6Y24_10935	COG2351	hydroxyisourate hydrolase activity
F6Y24_10940	COG4807	Protein conserved in bacteria
F6Y24_10950	COG0840	transmembrane signaling receptor activity
F6Y24_10955	COG1643	Atp-dependent helicase
F6Y24_10965	COG1187	pseudouridine synthase activity
F6Y24_10980	COG2130	NADP-dependent
F6Y24_10985	COG0656	L-ascorbic acid biosynthetic process
F6Y24_11010	COG1764	response to oxidative stress
F6Y24_11015	COG1846	Transcriptional regulator
F6Y24_11020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F6Y24_11030	COG0697	spore germination
F6Y24_11040	COG0523	cobalamin synthesis protein
F6Y24_11095	COG1960	acyl-CoA dehydrogenase activity
F6Y24_11100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F6Y24_11130	COG5001	Diguanylate cyclase
F6Y24_11135	COG2224	Isocitrate lyase
F6Y24_11140	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F6Y24_11145	COG0583	DNA-binding transcription factor activity
F6Y24_11150	COG0475	glutathione-regulated potassium exporter activity
F6Y24_11175	COG0681	Belongs to the peptidase S26 family
F6Y24_11180	COG0339	signal peptide processing
F6Y24_11185	COG1446	asparaginase
F6Y24_11205	COG0564	pseudouridine synthase activity
F6Y24_11225	COG1181	Belongs to the D-alanine--D-alanine ligase family
F6Y24_11240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F6Y24_11245	COG0318	PFAM AMP-dependent synthetase and ligase
F6Y24_11255	COG0596	Alpha beta hydrolase
F6Y24_11270	COG3177	Filamentation induced by cAMP protein fic
F6Y24_11275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F6Y24_11290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F6Y24_11315	COG2205	protein histidine kinase activity
F6Y24_11320	COG0028	Belongs to the TPP enzyme family
F6Y24_11330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F6Y24_11340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F6Y24_11380	COG0183	Belongs to the thiolase family
F6Y24_11395	COG2032	superoxide dismutase activity
F6Y24_11400	COG2032	superoxide dismutase activity
F6Y24_11405	COG2204	response regulator
F6Y24_11410	COG3852	Histidine kinase
F6Y24_11415	COG0004	ammonium transporteR
F6Y24_11420	COG0347	Belongs to the P(II) protein family
F6Y24_11425	COG0174	glutamine synthetase
F6Y24_11440	COG1881	PFAM PEBP family protein
F6Y24_11470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F6Y24_11475	COG2353	YceI-like domain
F6Y24_11480	COG2062	phosphohistidine phosphatase, SixA
F6Y24_11485	COG0489	protein tyrosine kinase activity
F6Y24_11515	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
F6Y24_11520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F6Y24_11535	COG1125	glycine betaine transport
F6Y24_11535	COG0517	IMP dehydrogenase activity
F6Y24_11550	COG1119	ATPase activity
F6Y24_11560	COG1752	Esterase of the alpha-beta hydrolase superfamily
F6Y24_11570	COG1522	sequence-specific DNA binding
F6Y24_11575	COG3186	Phenylalanine-4-hydroxylase
F6Y24_11585	COG2755	lipolytic protein G-D-S-L family
F6Y24_11595	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_11600	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
F6Y24_11610	COG1609	Transcriptional regulator
F6Y24_11615	COG3507	Belongs to the glycosyl hydrolase 43 family
F6Y24_11630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F6Y24_11640	COG2755	lipolytic protein G-D-S-L family
F6Y24_11640	COG0657	acetylesterase activity
F6Y24_11685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F6Y24_11690	COG0366	Alpha amylase catalytic
F6Y24_11695	COG0366	Alpha amylase catalytic
F6Y24_11735	COG1595	DNA-templated transcription, initiation
F6Y24_11820	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F6Y24_11845	COG4585	Histidine kinase
F6Y24_11850	COG1755	Isoprenylcysteine carboxyl methyltransferase
F6Y24_11855	COG1304	FMN binding
F6Y24_11885	COG1012	belongs to the aldehyde dehydrogenase family
F6Y24_11890	COG3284	Transcriptional regulator
F6Y24_11915	COG2423	ornithine cyclodeaminase activity
F6Y24_11925	COG4772	TonB-dependent receptor
F6Y24_11955	COG1309	transcriptional regulator
F6Y24_12000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F6Y24_12050	COG3237	CsbD-like
F6Y24_12085	COG1733	regulation of RNA biosynthetic process
F6Y24_12100	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_12105	COG0583	DNA-binding transcription factor activity
F6Y24_12145	COG1272	protein, Hemolysin III
F6Y24_12150	COG1205	dead DEAH box helicase
F6Y24_12150	COG1111	helicase
F6Y24_12200	COG3459	Glycosyltransferase 36 associated
F6Y24_12235	COG0067	glutamate synthase
F6Y24_12235	COG0069	glutamate synthase activity
F6Y24_12235	COG0070	glutamate synthase
F6Y24_12240	COG0493	'glutamate synthase
F6Y24_12250	COG1064	alcohol dehydrogenase
F6Y24_12260	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
F6Y24_12265	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
F6Y24_12270	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
F6Y24_12280	COG2234	aminopeptidase activity
F6Y24_12290	COG4942	peptidase
F6Y24_12295	COG0793	Belongs to the peptidase S41A family
F6Y24_12300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F6Y24_12330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F6Y24_12340	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F6Y24_12375	COG0501	Belongs to the peptidase M48B family
F6Y24_12385	COG0187	DNA topoisomerase II activity
F6Y24_12400	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F6Y24_12410	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F6Y24_12420	COG0706	membrane insertase activity
F6Y24_12425	COG0726	polysaccharide deacetylase
F6Y24_12430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F6Y24_12435	COG0671	phosphoesterase, PA-phosphatase related
F6Y24_12445	COG0584	glycerophosphoryl diester phosphodiesterase
F6Y24_12455	COG0861	Integral membrane protein TerC family
F6Y24_12465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F6Y24_12515	COG2271	Major facilitator Superfamily
F6Y24_12520	COG1929	Belongs to the glycerate kinase type-1 family
F6Y24_12530	COG3706	GGDEF domain
F6Y24_12545	COG3537	Alpha-1,2-mannosidase
F6Y24_12550	COG0531	amino acid
F6Y24_12560	COG1322	Protein conserved in bacteria
F6Y24_12570	COG0386	Belongs to the glutathione peroxidase family
F6Y24_12580	COG2853	Lipoprotein
F6Y24_12595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F6Y24_12600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F6Y24_12605	COG1127	ABC transporter
F6Y24_12640	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F6Y24_12645	COG1074	ATP-dependent DNA helicase activity
F6Y24_12650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F6Y24_12655	COG3549	Plasmid maintenance system killer
F6Y24_12685	COG0564	pseudouridine synthase activity
F6Y24_12750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F6Y24_12755	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
F6Y24_12765	COG0477	Major facilitator Superfamily
F6Y24_12770	COG1289	transmembrane transporter activity
F6Y24_12780	COG1566	PFAM secretion protein HlyD family protein
F6Y24_12795	COG0302	gtp cyclohydrolase
F6Y24_12820	COG0730	response to heat
F6Y24_12825	COG3012	SEC-C Motif Domain Protein
F6Y24_12845	COG0676	glucose-6-phosphate 1-epimerase activity
F6Y24_12870	COG3135	benzoate transporter
F6Y24_12900	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F6Y24_12910	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
F6Y24_12920	COG1435	thymidine kinase activity
F6Y24_12925	COG0210	DNA helicase
F6Y24_12940	COG3132	Protein of unknown function, DUF480
F6Y24_12945	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
F6Y24_12950	COG0284	orotidine-5'-phosphate decarboxylase activity
F6Y24_12980	COG2937	Belongs to the GPAT DAPAT family
F6Y24_13050	COG1904	glucuronate isomerase
F6Y24_13055	COG3250	beta-galactosidase activity
F6Y24_13085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F6Y24_13110	COG0246	Mannitol dehydrogenase
F6Y24_13115	COG1472	Belongs to the glycosyl hydrolase 3 family
F6Y24_13125	COG4948	Mandelate Racemase Muconate Lactonizing
F6Y24_13135	COG3661	Belongs to the glycosyl hydrolase 67 family
F6Y24_13150	COG0037	tRNA processing
F6Y24_13155	COG2974	May be involved in recombination
F6Y24_13175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F6Y24_13185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F6Y24_13190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F6Y24_13195	COG0805	protein transport
F6Y24_13205	COG0519	Catalyzes the synthesis of GMP from XMP
F6Y24_13205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F6Y24_13230	COG0457	Tetratricopeptide repeat
F6Y24_13235	COG4771	TonB-dependent receptor
F6Y24_13240	COG0729	surface antigen
F6Y24_13245	COG2911	Protein conserved in bacteria
F6Y24_13265	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F6Y24_13270	COG3265	gluconokinase activity
F6Y24_13275	COG2211	Major facilitator Superfamily
F6Y24_13280	COG3459	Glycosyltransferase 36 associated
F6Y24_13285	COG0784	Response regulator, receiver
F6Y24_13285	COG2205	protein histidine kinase activity
F6Y24_13290	COG1971	Probably functions as a manganese efflux pump
F6Y24_13295	COG1414	Transcriptional regulator
F6Y24_13300	COG0738	Major facilitator superfamily
F6Y24_13305	COG3254	rhamnose metabolic process
F6Y24_13310	COG4948	Mandelate Racemase Muconate Lactonizing
F6Y24_13315	COG0179	Fumarylacetoacetate (FAA) hydrolase
F6Y24_13320	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_13335	COG3507	Belongs to the glycosyl hydrolase 43 family
F6Y24_13385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F6Y24_13395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F6Y24_13405	COG1940	carbohydrate kinase activity
F6Y24_13425	COG2091	lysine biosynthetic process via aminoadipic acid
F6Y24_13435	COG3540	Alkaline phosphatase
F6Y24_13440	COG0357	Ribosomal RNA small subunit methyltransferase G
F6Y24_13460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6Y24_13470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F6Y24_13475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F6Y24_13480	COG2159	amidohydrolase
F6Y24_13490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F6Y24_13495	COG0583	DNA-binding transcription factor activity
F6Y24_13500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F6Y24_13515	COG0210	DNA helicase
F6Y24_13595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F6Y24_13610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F6Y24_13640	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_13665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F6Y24_13670	COG3100	YcgL domain-containing protein
F6Y24_13690	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F6Y24_13700	COG2239	Acts as a magnesium transporter
F6Y24_13705	COG1042	CoA-binding domain protein
F6Y24_13705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F6Y24_13705	COG0045	succinate-CoA ligase (ADP-forming) activity
F6Y24_13720	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F6Y24_13725	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F6Y24_13740	COG1607	acyl-coa hydrolase
F6Y24_13750	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F6Y24_13755	COG0842	Transport permease protein
F6Y24_13760	COG1131	(ABC) transporter
F6Y24_13795	COG1476	TRANSCRIPTIONal
F6Y24_13805	COG4555	ABC transporter
F6Y24_13840	COG0625	glutathione transferase activity
F6Y24_13900	COG1199	ATP-dependent helicase activity
F6Y24_13930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F6Y24_13940	COG0745	RESPONSE REGULATOR receiver
F6Y24_13945	COG2205	protein histidine kinase activity
F6Y24_13970	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F6Y24_13970	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F6Y24_13975	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F6Y24_13990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F6Y24_14035	COG3237	CsbD-like
F6Y24_14040	COG0180	Tryptophanyl-tRNA synthetase
F6Y24_14045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F6Y24_14065	COG0697	spore germination
F6Y24_14090	COG1136	(ABC) transporter
F6Y24_14095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6Y24_14100	COG4585	Histidine kinase
F6Y24_14105	COG2197	response regulator
F6Y24_14135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F6Y24_14140	COG1011	Hydrolase
F6Y24_14145	COG0628	permease
F6Y24_14185	COG0642	Histidine kinase
F6Y24_14190	COG0745	RESPONSE REGULATOR receiver
F6Y24_14195	COG1090	epimerase
F6Y24_14245	COG4943	cyclic-guanylate-specific phosphodiesterase activity
F6Y24_14270	COG3002	Belongs to the UPF0753 family
F6Y24_14315	COG0210	DNA helicase
F6Y24_14350	COG2960	long-chain fatty acid transporting porin activity
F6Y24_14370	COG3002	Belongs to the UPF0753 family
F6Y24_14390	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F6Y24_14395	COG1166	arginine decarboxylase activity
F6Y24_14400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F6Y24_14400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F6Y24_14410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F6Y24_14410	COG2755	lipolytic protein G-D-S-L family
F6Y24_14415	COG4221	oxidoreductase activity
F6Y24_14430	COG0018	arginyl-trna synthetase
F6Y24_14440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F6Y24_14465	COG0463	Glycosyl transferase, family 2
F6Y24_14485	COG1475	DNA binding
F6Y24_14490	COG1192	Involved in chromosome partitioning
F6Y24_14505	COG0708	Exodeoxyribonuclease III
F6Y24_14510	COG2211	Major facilitator Superfamily
F6Y24_14525	COG0739	heme binding
F6Y24_14570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F6Y24_14585	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
F6Y24_14615	COG0109	protoheme IX farnesyltransferase activity
F6Y24_14635	COG0358	DNA primase activity
F6Y24_14640	COG1295	ribonuclease BN
F6Y24_14645	COG1610	YqeY-like protein
F6Y24_14650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F6Y24_14660	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F6Y24_14670	COG2133	pyrroloquinoline quinone binding
F6Y24_14675	COG4682	membrane
F6Y24_14690	COG0531	amino acid
F6Y24_14700	COG4948	Mandelate Racemase Muconate Lactonizing
F6Y24_14710	COG3023	N-Acetylmuramoyl-L-alanine amidase
F6Y24_14715	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
F6Y24_14760	COG5383	Protein conserved in bacteria
F6Y24_14775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F6Y24_14785	COG1473	amidohydrolase
F6Y24_14790	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F6Y24_14790	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F6Y24_14810	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
F6Y24_14820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F6Y24_14825	COG3118	belongs to the thioredoxin family
F6Y24_14835	COG2884	Cell division ATP-binding protein ftsE
F6Y24_14840	COG2177	Part of the ABC transporter FtsEX involved in
F6Y24_14845	COG3437	response regulator, receiver
F6Y24_14850	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F6Y24_14855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F6Y24_14860	COG2860	membrane
F6Y24_14865	COG1252	NADH dehydrogenase
F6Y24_14880	COG0625	glutathione transferase activity
F6Y24_14885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F6Y24_14900	COG0534	Mate efflux family protein
F6Y24_14905	COG0616	signal peptide processing
F6Y24_14915	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_14935	COG1754	DNA topoisomerase type I activity
F6Y24_14935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F6Y24_14955	COG0758	DNA mediated transformation
F6Y24_14960	COG1652	LysM domain
F6Y24_14965	COG0242	peptide deformylase activity
F6Y24_14975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F6Y24_14975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F6Y24_14995	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F6Y24_15015	COG2951	lytic endotransglycosylase activity
F6Y24_15020	COG4644	lycopene metabolic process
F6Y24_15065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F6Y24_15075	COG1560	Kdo2-lipid A biosynthetic process
F6Y24_15080	COG1490	D-aminoacyl-tRNA deacylase activity
F6Y24_15085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F6Y24_15185	COG3081	Nucleoid-associated protein
F6Y24_15240	COG0456	acetyltransferase
F6Y24_15275	COG0784	Response regulator, receiver
F6Y24_15275	COG4191	Histidine kinase
F6Y24_15295	COG3179	chitinase
F6Y24_15340	COG4695	Portal protein
F6Y24_15350	COG0642	Histidine kinase
F6Y24_15405	COG0038	chloride channel
F6Y24_15410	COG0659	secondary active sulfate transmembrane transporter activity
F6Y24_15445	COG0840	transmembrane signaling receptor activity
F6Y24_15460	COG0251	oxidation-reduction process
F6Y24_15520	COG2814	Major facilitator Superfamily
F6Y24_15525	COG0583	DNA-binding transcription factor activity
F6Y24_15550	COG1063	alcohol dehydrogenase
F6Y24_15580	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_15590	COG2204	response regulator
F6Y24_15615	COG3546	catalase activity
F6Y24_15620	COG3685	Protein conserved in bacteria
F6Y24_15640	COG2972	Histidine kinase
F6Y24_15655	COG0531	amino acid
F6Y24_15670	COG3590	peptidase
F6Y24_15680	COG0667	Aldo Keto reductase
F6Y24_15690	COG0583	DNA-binding transcription factor activity
F6Y24_15700	COG3384	dioxygenase
F6Y24_15710	COG1573	uracil-dna glycosylase
F6Y24_15715	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
F6Y24_15725	COG0025	NhaP-type Na H and K H
F6Y24_15730	COG1131	(ABC) transporter
F6Y24_15735	COG0842	Transport permease protein
F6Y24_15785	COG1522	sequence-specific DNA binding
F6Y24_15790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F6Y24_15795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F6Y24_15815	COG2202	Pas domain
F6Y24_15815	COG2205	protein histidine kinase activity
F6Y24_15840	COG1187	pseudouridine synthase activity
F6Y24_15860	COG0784	Response regulator, receiver
F6Y24_15860	COG2198	Histidine kinase
F6Y24_15860	COG5002	protein histidine kinase activity
F6Y24_15870	COG1666	GTP binding
F6Y24_15875	COG0697	spore germination
F6Y24_15880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F6Y24_15885	COG2011	ABC-type metal ion transport system permease component
F6Y24_15920	COG0508	dehydrogenase complex catalyzes the overall conversion of
F6Y24_15930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F6Y24_15950	COG0356	it plays a direct role in the translocation of protons across the membrane
F6Y24_15960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F6Y24_15965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F6Y24_15975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F6Y24_15985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F6Y24_16000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F6Y24_16010	COG4191	Histidine kinase
F6Y24_16015	COG2204	response regulator
F6Y24_16035	COG1136	(ABC) transporter
F6Y24_16040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6Y24_16045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F6Y24_16095	COG0339	signal peptide processing
F6Y24_16105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F6Y24_16115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F6Y24_16120	COG0546	phosphoglycolate phosphatase activity
F6Y24_16130	COG2819	hydrolase of the alpha beta superfamily
F6Y24_16140	COG1956	GAF domain-containing protein
F6Y24_16145	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F6Y24_16155	COG0720	synthase
F6Y24_16160	COG4771	TonB-dependent receptor
F6Y24_16170	COG0513	Belongs to the DEAD box helicase family
F6Y24_16185	COG0625	glutathione transferase activity
F6Y24_16215	COG0626	cystathionine gamma-synthase activity
F6Y24_16235	COG0438	transferase activity, transferring glycosyl groups
F6Y24_16235	COG1216	Glycosyl transferase, family 2
F6Y24_16275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F6Y24_16280	COG0300	oxidoreductase activity
F6Y24_16285	COG0277	FAD linked oxidase domain protein
F6Y24_16290	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F6Y24_16290	COG0546	phosphoglycolate phosphatase activity
F6Y24_16305	COG2086	electron transfer activity
F6Y24_16330	COG0662	Cupin 2, conserved barrel domain protein
F6Y24_16330	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
F6Y24_16335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F6Y24_16340	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F6Y24_16375	COG3218	ABC-type transport auxiliary lipoprotein component
F6Y24_16375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F6Y24_16380	COG1127	ABC transporter
F6Y24_16385	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F6Y24_16410	COG1183	phosphatidylcholine synthase activity
F6Y24_16435	COG0525	valine-tRNA ligase activity
F6Y24_16455	COG0795	lipopolysaccharide-transporting ATPase activity
F6Y24_16465	COG4974	Belongs to the 'phage' integrase family
F6Y24_16470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F6Y24_16475	COG0047	phosphoribosylformylglycinamidine synthase activity
F6Y24_16475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F6Y24_16480	COG5295	Hep Hag repeat protein
F6Y24_16485	COG1404	Belongs to the peptidase S8 family
F6Y24_16495	COG1404	Belongs to the peptidase S8 family
F6Y24_16500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F6Y24_16505	COG1459	type II secretion system
F6Y24_16510	COG2165	general secretion pathway protein
F6Y24_16515	COG4970	Tfp pilus assembly protein FimT
F6Y24_16520	COG2165	general secretion pathway protein
F6Y24_16525	COG4795	General secretion pathway protein
F6Y24_16530	COG3156	type II secretion system protein K
F6Y24_16535	COG3166	PFAM Fimbrial assembly family protein
F6Y24_16550	COG1450	Type ii and iii secretion system protein
F6Y24_16560	COG2188	Transcriptional regulator
F6Y24_16625	COG0242	peptide deformylase activity
F6Y24_16630	COG0488	(ABC) transporter
F6Y24_16640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F6Y24_16655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F6Y24_16655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F6Y24_16680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F6Y24_16685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F6Y24_16745	COG1228	amidohydrolase
F6Y24_16750	COG3964	amidohydrolase
F6Y24_16765	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F6Y24_16770	COG0726	polysaccharide deacetylase
F6Y24_16775	COG4773	Receptor
F6Y24_16865	COG2211	Major facilitator Superfamily
F6Y24_16875	COG1609	Transcriptional regulator
F6Y24_16880	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_16885	COG2851	Citrate transporter
F6Y24_16905	COG0642	Histidine kinase
F6Y24_16910	COG1840	ABC-type Fe3 transport system, periplasmic component
F6Y24_16915	COG2197	response regulator
F6Y24_16920	COG0667	Aldo Keto reductase
F6Y24_16935	COG0583	DNA-binding transcription factor activity
F6Y24_16950	COG4191	Histidine kinase
F6Y24_16965	COG0280	phosphate acetyltransferase
F6Y24_16965	COG0281	malic enzyme
F6Y24_16990	COG1560	Kdo2-lipid A biosynthetic process
F6Y24_16995	COG1519	Transferase
F6Y24_17005	COG1538	Outer membrane efflux protein
F6Y24_17010	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F6Y24_17035	COG0066	3-isopropylmalate dehydratase activity
F6Y24_17045	COG0473	3-isopropylmalate dehydrogenase activity
F6Y24_17055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F6Y24_17080	COG0405	Gamma-glutamyltransferase
F6Y24_17090	COG0823	Involved in the tonB-independent uptake of proteins
F6Y24_17090	COG1506	peptidase
F6Y24_17090	COG4946	Tricorn protease homolog
F6Y24_17110	COG3710	Transcriptional regulator
F6Y24_17130	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F6Y24_17140	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F6Y24_17155	COG0563	adenylate kinase activity
F6Y24_17160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F6Y24_17170	COG3781	membrane
F6Y24_17175	COG0671	phosphoesterase, PA-phosphatase related
F6Y24_17185	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_17210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F6Y24_17240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F6Y24_17245	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
F6Y24_17260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F6Y24_17280	COG0352	thiamine-phosphate diphosphorylase activity
F6Y24_17285	COG1773	rubredoxin
F6Y24_17295	COG2912	Transglutaminase-like superfamily
F6Y24_17315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F6Y24_17340	COG0006	proline dipeptidase activity
F6Y24_17350	COG0006	proline dipeptidase activity
F6Y24_17365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F6Y24_17380	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F6Y24_17385	COG1561	YicC-like family, N-terminal region
F6Y24_17395	COG1758	RNA polymerase activity
F6Y24_17400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F6Y24_17410	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F6Y24_17435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F6Y24_17465	COG0714	Associated with various cellular activities
F6Y24_17495	COG1301	dicarboxylic acid transport
F6Y24_17500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F6Y24_17505	COG4773	Receptor
F6Y24_17510	COG0583	DNA-binding transcription factor activity
F6Y24_17515	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_17520	COG0739	heme binding
F6Y24_17525	COG1376	ErfK ybiS ycfS ynhG family protein
F6Y24_17570	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F6Y24_17575	COG4149	molybdate abc transporter
F6Y24_17580	COG0725	ABC transporter, periplasmic molybdate-binding protein
F6Y24_17585	COG3453	Protein conserved in bacteria
F6Y24_17585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F6Y24_17595	COG3047	cAMP biosynthetic process
F6Y24_17610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F6Y24_17640	COG0469	pyruvate kinase activity
F6Y24_17645	COG3588	fructose-bisphosphate aldolase
F6Y24_17650	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
F6Y24_17665	COG1648	precorrin-2 dehydrogenase activity
F6Y24_17665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F6Y24_17685	COG0784	Response regulator, receiver
F6Y24_17685	COG2198	Histidine kinase
F6Y24_17685	COG2205	protein histidine kinase activity
F6Y24_17710	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F6Y24_17715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F6Y24_17725	COG2895	sulfate adenylyltransferase (ATP) activity
F6Y24_17725	COG0529	Catalyzes the synthesis of activated sulfate
F6Y24_17730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6Y24_17735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F6Y24_17760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F6Y24_17765	COG2272	Belongs to the type-B carboxylesterase lipase family
F6Y24_17775	COG4948	Mandelate Racemase Muconate Lactonizing
F6Y24_17780	COG3250	beta-galactosidase activity
F6Y24_17790	COG1609	Transcriptional regulator
F6Y24_17800	COG1970	mechanosensitive ion channel activity
F6Y24_17820	COG0471	metal ion transport
F6Y24_17820	COG3273	potassium ion transport
F6Y24_17850	COG0582	viral genome integration into host DNA
F6Y24_17870	COG1396	sequence-specific DNA binding
F6Y24_17875	COG0583	DNA-binding transcription factor activity
F6Y24_18015	COG5001	Diguanylate cyclase
F6Y24_18285	COG0189	ligase activity
F6Y24_18295	COG0745	RESPONSE REGULATOR receiver
F6Y24_18315	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F6Y24_18345	COG0045	succinate-CoA ligase (ADP-forming) activity
F6Y24_18355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F6Y24_18355	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F6Y24_18365	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F6Y24_18370	COG0564	pseudouridine synthase activity
F6Y24_18385	COG0840	transmembrane signaling receptor activity
F6Y24_18405	COG3387	PFAM Glycoside hydrolase 15-related
F6Y24_18410	COG1877	trehalose-phosphatase activity
F6Y24_18460	COG4771	TonB-dependent receptor
F6Y24_18470	COG0667	Aldo Keto reductase
F6Y24_18475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F6Y24_18480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F6Y24_18490	COG0542	response to heat
F6Y24_18510	COG4206	TonB-dependent receptor
F6Y24_18520	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F6Y24_18535	COG0019	diaminopimelate decarboxylase activity
F6Y24_18540	COG4264	IucA IucC family
F6Y24_18545	COG2814	Major facilitator Superfamily
F6Y24_18550	COG4264	IucA IucC family
F6Y24_18560	COG4772	TonB-dependent receptor
F6Y24_18585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F6Y24_18585	COG4651	solute:proton antiporter activity
F6Y24_18620	COG0488	(ABC) transporter
F6Y24_18655	COG0477	Major facilitator Superfamily
F6Y24_18695	COG0632	four-way junction helicase activity
F6Y24_18715	COG0824	Thioesterase
F6Y24_18725	COG0848	biopolymer transport protein
F6Y24_18735	COG0823	Involved in the tonB-independent uptake of proteins
F6Y24_18740	COG2885	chlorophyll binding
F6Y24_18750	COG0602	queuosine metabolic process
F6Y24_18755	COG0667	Aldo Keto reductase
F6Y24_18795	COG0840	transmembrane signaling receptor activity
F6Y24_18805	COG1187	pseudouridine synthase activity
F6Y24_18830	COG0514	ATP-dependent DNA helicase (RecQ)
F6Y24_18840	COG0783	Belongs to the Dps family
F6Y24_18845	COG1643	Atp-dependent helicase
F6Y24_18860	COG0837	glucose binding
F6Y24_18880	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
F6Y24_18885	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F6Y24_18895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F6Y24_18910	COG1215	transferase activity, transferring glycosyl groups
F6Y24_18915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F6Y24_18925	COG1199	ATP-dependent helicase activity
F6Y24_18935	COG1397	ADP-ribosylglycohydrolase
F6Y24_18945	COG0189	ligase activity
F6Y24_18960	COG0835	chemotaxis
F6Y24_18965	COG0840	transmembrane signaling receptor activity
F6Y24_18995	COG1595	DNA-templated transcription, initiation
F6Y24_19000	COG2304	oxidoreductase activity
F6Y24_19005	COG1446	asparaginase
F6Y24_19010	COG3142	Participates in the control of copper homeostasis
F6Y24_19040	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F6Y24_19055	COG3645	SOS response
F6Y24_19095	COG3537	Alpha-1,2-mannosidase
F6Y24_19105	COG1486	melibiose metabolic process
F6Y24_19115	COG0531	amino acid
F6Y24_19130	COG1472	Belongs to the glycosyl hydrolase 3 family
F6Y24_19145	COG1388	LysM domain
F6Y24_19145	COG3858	chitin binding
F6Y24_19160	COG0837	glucose binding
F6Y24_19165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F6Y24_19175	COG0494	nUDIX hydrolase
F6Y24_19185	COG3956	TIGRFAM MazG family protein
F6Y24_19190	COG1742	UPF0060 membrane protein
F6Y24_19195	COG0330	HflC and HflK could
F6Y24_19205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F6Y24_19210	COG0509	glycine decarboxylation via glycine cleavage system
F6Y24_19240	COG1960	acyl-CoA dehydrogenase activity
F6Y24_19250	COG1309	transcriptional regulator
F6Y24_19255	COG4771	TonB-dependent receptor
F6Y24_19265	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F6Y24_19270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F6Y24_19275	COG0463	Glycosyl transferase, family 2
F6Y24_19280	COG0517	IMP dehydrogenase activity
F6Y24_19280	COG0516	GMP reductase activity
F6Y24_19285	COG2982	Protein involved in outer membrane biogenesis
F6Y24_19290	COG1272	protein, Hemolysin III
F6Y24_19295	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F6Y24_19300	COG0739	heme binding
F6Y24_19305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F6Y24_19310	COG0626	cystathionine gamma-synthase activity
F6Y24_19315	COG0460	homoserine dehydrogenase
F6Y24_19315	COG0527	aspartate kinase activity
F6Y24_19325	COG1760	l-serine dehydratase
F6Y24_19340	COG3038	cytochrome b561
F6Y24_19345	COG2353	YceI-like domain
F6Y24_19350	COG0784	Response regulator, receiver
F6Y24_19350	COG2198	Histidine kinase
F6Y24_19350	COG2205	protein histidine kinase activity
F6Y24_19360	COG0477	Major facilitator Superfamily
F6Y24_19365	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F6Y24_19375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F6Y24_19380	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F6Y24_19400	COG1842	Phage shock protein A
F6Y24_19425	COG0754	glutathionylspermidine amidase activity
F6Y24_19435	COG2814	Major facilitator Superfamily
F6Y24_19475	COG0531	amino acid
F6Y24_19480	COG2197	response regulator
F6Y24_19495	COG1113	amino acid transport
F6Y24_19510	COG1271	oxidase subunit
F6Y24_19515	COG1294	oxidase, subunit
F6Y24_19525	COG2239	Acts as a magnesium transporter
F6Y24_19530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F6Y24_19535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6Y24_19555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F6Y24_19570	COG1137	ATPase activity
F6Y24_19575	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F6Y24_19585	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F6Y24_19595	COG0271	Belongs to the BolA IbaG family
F6Y24_19620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F6Y24_19640	COG0628	permease
F6Y24_19655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F6Y24_19660	COG3178	'Phosphotransferase
F6Y24_19670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F6Y24_19675	COG1555	photosystem II stabilization
F6Y24_19690	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F6Y24_19695	COG1477	protein flavinylation
F6Y24_19720	COG3128	pkhd-type hydroxylase
F6Y24_19725	COG4774	siderophore transport
F6Y24_19745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F6Y24_19750	COG0719	Fe-S assembly protein
F6Y24_19755	COG0396	ATPase activity
F6Y24_19760	COG0719	Fe-S assembly protein
F6Y24_19765	COG1959	2 iron, 2 sulfur cluster binding
F6Y24_19775	COG0693	protein deglycase activity
F6Y24_19795	COG4942	peptidase
F6Y24_19810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F6Y24_19830	COG0519	Catalyzes the synthesis of GMP from XMP
F6Y24_19835	COG1678	Uncharacterized ACR, COG1678
F6Y24_19840	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F6Y24_19845	COG0540	Belongs to the ATCase OTCase family
F6Y24_19855	COG1764	response to oxidative stress
F6Y24_19865	COG0384	phenazine biosynthesis protein PhzF
F6Y24_19870	COG0384	phenazine biosynthesis protein PhzF
F6Y24_19875	COG0527	aspartate kinase activity
F6Y24_19900	COG0142	geranyltranstransferase activity
F6Y24_19905	COG0629	single-stranded DNA binding
F6Y24_19910	COG2203	Gaf domain
F6Y24_19910	COG5001	Diguanylate cyclase
F6Y24_19910	COG4251	negative regulation of phosphorylation
F6Y24_19910	COG3706	GGDEF domain
F6Y24_19915	COG1028	Short-chain dehydrogenase reductase Sdr
F6Y24_19915	COG3321	synthase
F6Y24_19915	COG0604	alcohol dehydrogenase
F6Y24_19920	COG2080	2 iron, 2 sulfur cluster binding
F6Y24_19925	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F6Y24_19930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F6Y24_19935	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F6Y24_19970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F6Y24_19980	COG2879	small protein
F6Y24_19990	COG1966	Carbon starvation protein
F6Y24_19995	COG1741	Belongs to the pirin family
F6Y24_20010	COG1741	Belongs to the pirin family
F6Y24_20025	COG1515	deoxyribonuclease V activity
F6Y24_20030	COG0588	phosphoglycerate mutase activity
F6Y24_20040	COG3590	peptidase
F6Y24_20045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F6Y24_20055	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F6Y24_20060	COG2199	diguanylate cyclase activity
F6Y24_20060	COG2200	EAL domain
F6Y24_20060	COG2202	Pas domain
F6Y24_20065	COG0835	chemotaxis
F6Y24_20070	COG0840	transmembrane signaling receptor activity
F6Y24_20075	COG2198	Histidine kinase
F6Y24_20075	COG0643	Histidine kinase
F6Y24_20085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F6Y24_20105	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F6Y24_20110	COG0745	RESPONSE REGULATOR receiver
F6Y24_20115	COG2205	protein histidine kinase activity
F6Y24_20135	COG4452	Inner membrane protein CreD
F6Y24_20160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F6Y24_20165	COG0735	belongs to the Fur family
F6Y24_20180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F6Y24_20185	COG1538	Outer membrane efflux protein
F6Y24_20205	COG2207	Transcriptional regulator
F6Y24_20220	COG0583	DNA-binding transcription factor activity
F6Y24_20225	COG2814	Major facilitator Superfamily
F6Y24_20230	COG0667	Aldo Keto reductase
F6Y24_20350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F6Y24_20380	COG5002	protein histidine kinase activity
F6Y24_20380	COG5001	Diguanylate cyclase
F6Y24_20385	COG1187	pseudouridine synthase activity
F6Y24_20390	COG3706	GGDEF domain
F6Y24_20390	COG0745	RESPONSE REGULATOR receiver
F6Y24_20405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F6Y24_20410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F6Y24_20415	COG0475	glutathione-regulated potassium exporter activity
F6Y24_20465	COG2155	Conserved Protein
F6Y24_20470	COG5487	UPF0391 membrane protein
F6Y24_20490	COG3118	belongs to the thioredoxin family
F6Y24_20500	COG0495	leucyl-tRNA aminoacylation
F6Y24_20520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F6Y24_20540	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F6Y24_20550	COG2968	Membrane
F6Y24_20555	COG0424	maF-like protein
F6Y24_20560	COG1530	ribonuclease E activity
F6Y24_20565	COG3164	Protein of unknown function
F6Y24_20575	COG0312	modulator of DNA gyrase
F6Y24_20585	COG0312	modulator of DNA gyrase
F6Y24_20600	COG0142	geranyltranstransferase activity
F6Y24_20605	COG1722	exodeoxyribonuclease VII activity
F6Y24_20610	COG0037	tRNA processing
F6Y24_20615	COG1785	Belongs to the alkaline phosphatase family
F6Y24_20620	COG1301	dicarboxylic acid transport
F6Y24_20635	COG0791	NLP P60 protein
F6Y24_20640	COG0791	NLP P60 protein
F6Y24_20645	COG1047	Peptidyl-prolyl cis-trans
F6Y24_20650	COG2311	Membrane
F6Y24_20655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F6Y24_20660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F6Y24_20685	COG3590	peptidase
F6Y24_20690	COG3590	peptidase
F6Y24_20710	COG0489	protein tyrosine kinase activity
F6Y24_20720	COG0717	Belongs to the dCTP deaminase family
F6Y24_20840	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F6Y24_20855	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F6Y24_20865	COG0497	DNA recombination
F6Y24_20870	COG1420	regulation of RNA biosynthetic process
F6Y24_20875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F6Y24_20880	COG0443	Heat shock 70 kDa protein
F6Y24_20890	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
F6Y24_20895	COG0287	Prephenate dehydrogenase
F6Y24_20895	COG1605	Chorismate mutase
F6Y24_20915	COG2274	protein secretion by the type I secretion system
F6Y24_20920	COG0583	DNA-binding transcription factor activity
F6Y24_20925	COG1132	(ABC) transporter
F6Y24_20935	COG1619	proteins homologs of microcin C7 resistance protein MccF
F6Y24_20975	COG2850	peptidyl-arginine hydroxylation
F6Y24_20990	COG1253	flavin adenine dinucleotide binding
F6Y24_21020	COG1131	(ABC) transporter
F6Y24_21025	COG1725	Transcriptional regulator
F6Y24_21035	COG0386	Belongs to the glutathione peroxidase family
F6Y24_21075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F6Y24_21085	COG0646	methionine synthase
F6Y24_21085	COG1410	methionine synthase
F6Y24_21090	COG1410	methionine synthase
F6Y24_21090	COG0646	methionine synthase
F6Y24_21100	COG1960	acyl-CoA dehydrogenase activity
F6Y24_21120	COG0557	exoribonuclease II activity
F6Y24_21130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F6Y24_21140	COG3706	GGDEF domain
F6Y24_21145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F6Y24_21155	COG0704	Plays a role in the regulation of phosphate uptake
F6Y24_21160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F6Y24_21165	COG0581	inorganic phosphate transmembrane transporter activity
F6Y24_21170	COG0573	inorganic phosphate transmembrane transporter activity
F6Y24_21175	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F6Y24_21200	COG0659	secondary active sulfate transmembrane transporter activity
F6Y24_21205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F6Y24_21215	COG1024	Enoyl-CoA hydratase
F6Y24_21225	COG0494	nUDIX hydrolase
F6Y24_21260	COG2264	protein methyltransferase activity
F6Y24_21280	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F6Y24_21305	COG2925	Exonuclease
F6Y24_21310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F6Y24_21315	COG3844	kynureninase activity
F6Y24_21325	COG0662	Cupin 2, conserved barrel domain protein
F6Y24_21330	COG0288	reversible hydration of carbon dioxide
F6Y24_21400	COG0017	Asparaginyl-tRNA synthetase
F6Y24_21410	COG0316	Belongs to the HesB IscA family
F6Y24_21435	COG3115	cell septum assembly
F6Y24_21450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F6Y24_21455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F6Y24_21460	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F6Y24_21480	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F6Y24_21490	COG4993	Dehydrogenase
F6Y24_21505	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F6Y24_21515	COG2986	histidine ammonia-lyase
F6Y24_21555	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
F6Y24_21560	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F6Y24_21565	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F6Y24_21570	COG0077	Prephenate dehydratase
F6Y24_21570	COG1605	Chorismate mutase
F6Y24_21575	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F6Y24_21590	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F6Y24_21595	COG0583	DNA-binding transcription factor activity
F6Y24_21620	COG0840	transmembrane signaling receptor activity
F6Y24_21640	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F6Y24_21655	COG0840	transmembrane signaling receptor activity
F6Y24_21675	COG4191	Histidine kinase
F6Y24_21675	COG0784	Response regulator, receiver
F6Y24_21680	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
F6Y24_21685	COG0784	Response regulator, receiver
F6Y24_21685	COG4191	Histidine kinase
F6Y24_21700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F6Y24_21720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F6Y24_21725	COG1404	Belongs to the peptidase S8 family
F6Y24_21735	COG1595	DNA-templated transcription, initiation
F6Y24_21785	COG2244	polysaccharide biosynthetic process
F6Y24_21815	COG2264	protein methyltransferase activity
F6Y24_21820	COG0438	transferase activity, transferring glycosyl groups
F6Y24_21825	COG0438	transferase activity, transferring glycosyl groups
F6Y24_21845	COG1136	(ABC) transporter
F6Y24_21850	COG1132	(ABC) transporter
F6Y24_21855	COG0477	Major facilitator Superfamily
F6Y24_21860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F6Y24_21875	COG1253	flavin adenine dinucleotide binding
F6Y24_21930	COG0148	phosphopyruvate hydratase activity
F6Y24_21945	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F6Y24_21955	COG2840	Smr protein MutS2
F6Y24_21960	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F6Y24_21965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F6Y24_21970	COG1238	metal cluster binding
F6Y24_21985	COG1534	Rna-binding protein
F6Y24_21990	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F6Y24_21995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F6Y24_22000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F6Y24_22010	COG1923	regulation of RNA biosynthetic process
F6Y24_22015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F6Y24_22020	COG1546	Belongs to the CinA family
F6Y24_22025	COG4771	TonB-dependent receptor
F6Y24_22030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F6Y24_22040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F6Y24_22045	COG2137	regulation of response to DNA damage stimulus
F6Y24_22050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F6Y24_22055	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F6Y24_22075	COG1741	Belongs to the pirin family
F6Y24_22080	COG0583	DNA-binding transcription factor activity
F6Y24_22105	COG0351	phosphomethylpyrimidine kinase
F6Y24_22105	COG0352	thiamine-phosphate diphosphorylase activity
F6Y24_22120	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F6Y24_22125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F6Y24_22140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F6Y24_22150	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F6Y24_22155	COG3734	2-keto-3-deoxy-galactonokinase
F6Y24_22170	COG0800	Aldolase
F6Y24_22210	COG1501	Belongs to the glycosyl hydrolase 31 family
F6Y24_22220	COG1070	Carbohydrate kinase
F6Y24_22230	COG0477	Major facilitator Superfamily
F6Y24_22250	COG0860	N-Acetylmuramoyl-L-alanine amidase
F6Y24_22275	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F6Y24_22280	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F6Y24_22315	COG1472	Belongs to the glycosyl hydrolase 3 family
F6Y24_22330	COG4251	negative regulation of phosphorylation
F6Y24_22330	COG3706	GGDEF domain
F6Y24_22330	COG2203	Gaf domain
F6Y24_22330	COG5001	Diguanylate cyclase
F6Y24_22335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
F6Y24_22350	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
F6Y24_22360	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F6Y24_22365	COG0671	phosphoesterase, PA-phosphatase related
F6Y24_22385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F6Y24_22405	COG1012	belongs to the aldehyde dehydrogenase family
F6Y24_22460	COG0515	serine threonine protein kinase
F6Y24_22460	COG2815	serine threonine protein kinase
F6Y24_22535	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
F6Y24_22535	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
F6Y24_22565	COG1215	transferase activity, transferring glycosyl groups
F6Y24_22570	COG0726	polysaccharide deacetylase
F6Y24_22570	COG1649	PFAM Uncharacterised BCR, COG1649
F6Y24_22600	COG2801	Transposase and inactivated derivatives
F6Y24_22615	COG0460	homoserine dehydrogenase
F6Y24_22615	COG0527	aspartate kinase activity
F6Y24_22640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F6Y24_22660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F6Y24_22665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F6Y24_22670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F6Y24_22670	COG0131	Imidazoleglycerol-phosphate dehydratase
F6Y24_22675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F6Y24_22680	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F6Y24_22690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F6Y24_22690	COG0140	phosphoribosyl-ATP diphosphatase activity
F6Y24_22725	COG0531	amino acid
F6Y24_22730	COG0531	amino acid
F6Y24_22745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F6Y24_22750	COG0277	FAD linked oxidase domain protein
F6Y24_22770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase