locus-tag	class	description
L1B16_00015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1B16_00025	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_00055	COG1677	Flagellar hook-basal body complex protein FliE
L1B16_00120	COG1684	flagellar biosynthetic protein fliR
L1B16_00125	COG3300	MHYT domain
L1B16_00125	COG5001	Diguanylate cyclase
L1B16_00175	COG2198	Histidine kinase
L1B16_00175	COG0784	Response regulator, receiver
L1B16_00175	COG0643	Histidine kinase
L1B16_00230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L1B16_00235	COG1360	Flagellar Motor Protein
L1B16_00245	COG0835	chemotaxis
L1B16_00255	COG0745	RESPONSE REGULATOR receiver
L1B16_00265	COG0840	transmembrane signaling receptor activity
L1B16_00275	COG0840	transmembrane signaling receptor activity
L1B16_00280	COG0840	transmembrane signaling receptor activity
L1B16_00290	COG0840	transmembrane signaling receptor activity
L1B16_00295	COG0840	transmembrane signaling receptor activity
L1B16_00300	COG0840	transmembrane signaling receptor activity
L1B16_00305	COG0840	transmembrane signaling receptor activity
L1B16_00310	COG0840	transmembrane signaling receptor activity
L1B16_00315	COG0840	transmembrane signaling receptor activity
L1B16_00335	COG0835	chemotaxis
L1B16_00345	COG0840	transmembrane signaling receptor activity
L1B16_00370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1B16_00400	COG0318	PFAM AMP-dependent synthetase and ligase
L1B16_00405	COG1024	Enoyl-CoA hydratase
L1B16_00410	COG0784	Response regulator, receiver
L1B16_00410	COG2198	Histidine kinase
L1B16_00410	COG2205	protein histidine kinase activity
L1B16_00420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L1B16_00430	COG3279	Response regulator of the LytR AlgR family
L1B16_00445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L1B16_00455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L1B16_00460	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L1B16_00470	COG0505	Belongs to the CarA family
L1B16_00480	COG2258	MOSC domain
L1B16_00485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1B16_00525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L1B16_00545	COG0277	FAD linked oxidase domain protein
L1B16_00550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L1B16_00560	COG0531	amino acid
L1B16_00565	COG0531	amino acid
L1B16_00595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L1B16_00595	COG0140	phosphoribosyl-ATP diphosphatase activity
L1B16_00605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L1B16_00610	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L1B16_00615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L1B16_00615	COG0131	Imidazoleglycerol-phosphate dehydratase
L1B16_00620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L1B16_00625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L1B16_00645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L1B16_00670	COG0527	aspartate kinase activity
L1B16_00670	COG0460	homoserine dehydrogenase
L1B16_00715	COG1649	PFAM Uncharacterised BCR, COG1649
L1B16_00715	COG0726	polysaccharide deacetylase
L1B16_00720	COG1215	transferase activity, transferring glycosyl groups
L1B16_00745	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L1B16_00745	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L1B16_00810	COG2815	serine threonine protein kinase
L1B16_00810	COG0515	serine threonine protein kinase
L1B16_00880	COG1012	belongs to the aldehyde dehydrogenase family
L1B16_00900	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L1B16_00920	COG0671	phosphoesterase, PA-phosphatase related
L1B16_00925	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L1B16_00935	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
L1B16_00940	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L1B16_00945	COG5001	Diguanylate cyclase
L1B16_00945	COG2203	Gaf domain
L1B16_00945	COG3706	GGDEF domain
L1B16_00945	COG4251	negative regulation of phosphorylation
L1B16_00955	COG1472	Belongs to the glycosyl hydrolase 3 family
L1B16_00985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L1B16_00990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L1B16_01015	COG0860	N-Acetylmuramoyl-L-alanine amidase
L1B16_01030	COG0477	Major facilitator Superfamily
L1B16_01040	COG1070	Carbohydrate kinase
L1B16_01050	COG1501	Belongs to the glycosyl hydrolase 31 family
L1B16_01085	COG0800	Aldolase
L1B16_01090	COG4948	Mandelate Racemase Muconate Lactonizing
L1B16_01100	COG3734	2-keto-3-deoxy-galactonokinase
L1B16_01105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L1B16_01115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1B16_01130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L1B16_01135	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L1B16_01150	COG0351	phosphomethylpyrimidine kinase
L1B16_01150	COG0352	thiamine-phosphate diphosphorylase activity
L1B16_01175	COG0583	DNA-binding transcription factor activity
L1B16_01180	COG1741	Belongs to the pirin family
L1B16_01200	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L1B16_01205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L1B16_01210	COG2137	regulation of response to DNA damage stimulus
L1B16_01215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L1B16_01225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L1B16_01230	COG4771	TonB-dependent receptor
L1B16_01235	COG1546	Belongs to the CinA family
L1B16_01240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L1B16_01255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L1B16_01265	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
L1B16_01270	COG1534	Rna-binding protein
L1B16_01285	COG1238	metal cluster binding
L1B16_01290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L1B16_01295	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L1B16_01300	COG2840	Smr protein MutS2
L1B16_01310	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L1B16_01315	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L1B16_01325	COG0148	phosphopyruvate hydratase activity
L1B16_01375	COG1253	flavin adenine dinucleotide binding
L1B16_01390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1B16_01395	COG0477	Major facilitator Superfamily
L1B16_01400	COG1132	(ABC) transporter
L1B16_01405	COG1136	(ABC) transporter
L1B16_01425	COG0438	transferase activity, transferring glycosyl groups
L1B16_01430	COG0438	transferase activity, transferring glycosyl groups
L1B16_01435	COG2264	protein methyltransferase activity
L1B16_01465	COG2244	polysaccharide biosynthetic process
L1B16_01515	COG1595	DNA-templated transcription, initiation
L1B16_01525	COG1404	Belongs to the peptidase S8 family
L1B16_01530	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L1B16_01550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L1B16_01565	COG0784	Response regulator, receiver
L1B16_01565	COG4191	Histidine kinase
L1B16_01570	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
L1B16_01575	COG4191	Histidine kinase
L1B16_01575	COG0784	Response regulator, receiver
L1B16_01600	COG0840	transmembrane signaling receptor activity
L1B16_01615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L1B16_01635	COG0840	transmembrane signaling receptor activity
L1B16_01660	COG0583	DNA-binding transcription factor activity
L1B16_01665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L1B16_01680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L1B16_01685	COG1605	Chorismate mutase
L1B16_01685	COG0077	Prephenate dehydratase
L1B16_01690	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L1B16_01695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L1B16_01700	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
L1B16_01735	COG1228	amidohydrolase
L1B16_01740	COG2986	histidine ammonia-lyase
L1B16_01750	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
L1B16_01765	COG4993	Dehydrogenase
L1B16_01775	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L1B16_01790	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L1B16_01795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L1B16_01800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L1B16_01810	COG3115	cell septum assembly
L1B16_01835	COG0316	Belongs to the HesB IscA family
L1B16_01840	COG0017	Asparaginyl-tRNA synthetase
L1B16_01905	COG0288	reversible hydration of carbon dioxide
L1B16_01910	COG0662	Cupin 2, conserved barrel domain protein
L1B16_01920	COG3844	kynureninase activity
L1B16_01925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1B16_01930	COG2925	Exonuclease
L1B16_01945	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L1B16_01955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L1B16_01970	COG0488	(ABC) transporter
L1B16_01975	COG2264	protein methyltransferase activity
L1B16_02010	COG0494	nUDIX hydrolase
L1B16_02020	COG1024	Enoyl-CoA hydratase
L1B16_02030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L1B16_02060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L1B16_02065	COG0573	inorganic phosphate transmembrane transporter activity
L1B16_02070	COG0581	inorganic phosphate transmembrane transporter activity
L1B16_02075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L1B16_02080	COG0704	Plays a role in the regulation of phosphate uptake
L1B16_02090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L1B16_02105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1B16_02115	COG0557	exoribonuclease II activity
L1B16_02130	COG1960	acyl-CoA dehydrogenase activity
L1B16_02135	COG2226	methyltransferase
L1B16_02140	COG0646	methionine synthase
L1B16_02140	COG1410	methionine synthase
L1B16_02145	COG0646	methionine synthase
L1B16_02145	COG1410	methionine synthase
L1B16_02155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L1B16_02180	COG2900	Belongs to the SlyX family
L1B16_02195	COG0386	Belongs to the glutathione peroxidase family
L1B16_02205	COG1725	Transcriptional regulator
L1B16_02210	COG1131	(ABC) transporter
L1B16_02240	COG1253	flavin adenine dinucleotide binding
L1B16_02255	COG2850	peptidyl-arginine hydroxylation
L1B16_02295	COG1619	proteins homologs of microcin C7 resistance protein MccF
L1B16_02305	COG1132	(ABC) transporter
L1B16_02310	COG0583	DNA-binding transcription factor activity
L1B16_02315	COG2274	protein secretion by the type I secretion system
L1B16_02335	COG0287	Prephenate dehydrogenase
L1B16_02335	COG1605	Chorismate mutase
L1B16_02340	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
L1B16_02350	COG0443	Heat shock 70 kDa protein
L1B16_02355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L1B16_02360	COG1420	regulation of RNA biosynthetic process
L1B16_02365	COG0497	DNA recombination
L1B16_02375	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L1B16_02390	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L1B16_02510	COG0717	Belongs to the dCTP deaminase family
L1B16_02515	COG0489	protein tyrosine kinase activity
L1B16_02535	COG3590	peptidase
L1B16_02540	COG3590	peptidase
L1B16_02565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L1B16_02570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1B16_02575	COG2311	Membrane
L1B16_02580	COG1047	Peptidyl-prolyl cis-trans
L1B16_02585	COG0791	NLP P60 protein
L1B16_02590	COG0791	NLP P60 protein
L1B16_02605	COG1301	dicarboxylic acid transport
L1B16_02610	COG1785	Belongs to the alkaline phosphatase family
L1B16_02615	COG0037	tRNA processing
L1B16_02620	COG1722	exodeoxyribonuclease VII activity
L1B16_02625	COG0142	geranyltranstransferase activity
L1B16_02640	COG0312	modulator of DNA gyrase
L1B16_02650	COG0312	modulator of DNA gyrase
L1B16_02660	COG3164	Protein of unknown function
L1B16_02670	COG0424	maF-like protein
L1B16_02675	COG2968	Membrane
L1B16_02685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L1B16_02705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L1B16_02720	COG0495	leucyl-tRNA aminoacylation
L1B16_02730	COG3118	belongs to the thioredoxin family
L1B16_02755	COG2155	Conserved Protein
L1B16_02805	COG0475	glutathione-regulated potassium exporter activity
L1B16_02815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L1B16_02835	COG1187	pseudouridine synthase activity
L1B16_02840	COG5001	Diguanylate cyclase
L1B16_02840	COG5002	protein histidine kinase activity
L1B16_02980	COG0667	Aldo Keto reductase
L1B16_02985	COG2814	Major facilitator Superfamily
L1B16_02990	COG0583	DNA-binding transcription factor activity
L1B16_03000	COG2207	Transcriptional regulator
L1B16_03050	COG0735	belongs to the Fur family
L1B16_03055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L1B16_03080	COG4452	Inner membrane protein CreD
L1B16_03100	COG2205	protein histidine kinase activity
L1B16_03105	COG0745	RESPONSE REGULATOR receiver
L1B16_03110	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L1B16_03120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L1B16_03130	COG0643	Histidine kinase
L1B16_03130	COG2198	Histidine kinase
L1B16_03135	COG0840	transmembrane signaling receptor activity
L1B16_03140	COG0835	chemotaxis
L1B16_03145	COG2202	Pas domain
L1B16_03145	COG2200	EAL domain
L1B16_03145	COG2199	diguanylate cyclase activity
L1B16_03150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L1B16_03160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L1B16_03165	COG3590	peptidase
L1B16_03175	COG0588	phosphoglycerate mutase activity
L1B16_03180	COG1515	deoxyribonuclease V activity
L1B16_03195	COG1741	Belongs to the pirin family
L1B16_03210	COG1741	Belongs to the pirin family
L1B16_03215	COG1966	Carbon starvation protein
L1B16_03220	COG2879	small protein
L1B16_03225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L1B16_03265	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
L1B16_03270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1B16_03275	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L1B16_03280	COG2080	2 iron, 2 sulfur cluster binding
L1B16_03285	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_03285	COG3321	synthase
L1B16_03285	COG0604	alcohol dehydrogenase
L1B16_03290	COG2203	Gaf domain
L1B16_03290	COG3706	GGDEF domain
L1B16_03290	COG4251	negative regulation of phosphorylation
L1B16_03290	COG5001	Diguanylate cyclase
L1B16_03295	COG0629	single-stranded DNA binding
L1B16_03300	COG0142	geranyltranstransferase activity
L1B16_03325	COG0527	aspartate kinase activity
L1B16_03330	COG0384	phenazine biosynthesis protein PhzF
L1B16_03335	COG0384	phenazine biosynthesis protein PhzF
L1B16_03345	COG1764	response to oxidative stress
L1B16_03350	COG0540	Belongs to the ATCase OTCase family
L1B16_03355	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L1B16_03360	COG1678	Uncharacterized ACR, COG1678
L1B16_03365	COG0519	Catalyzes the synthesis of GMP from XMP
L1B16_03385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L1B16_03400	COG4942	peptidase
L1B16_03420	COG0693	protein deglycase activity
L1B16_03430	COG1959	2 iron, 2 sulfur cluster binding
L1B16_03435	COG0719	Fe-S assembly protein
L1B16_03440	COG0396	ATPase activity
L1B16_03445	COG0719	Fe-S assembly protein
L1B16_03450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L1B16_03460	COG2146	nitrite reductase [NAD(P)H] activity
L1B16_03465	COG4774	siderophore transport
L1B16_03470	COG3128	pkhd-type hydroxylase
L1B16_03495	COG1477	protein flavinylation
L1B16_03500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L1B16_03515	COG1555	photosystem II stabilization
L1B16_03520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1B16_03530	COG3178	'Phosphotransferase
L1B16_03535	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L1B16_03545	COG0628	permease
L1B16_03565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L1B16_03590	COG0271	Belongs to the BolA IbaG family
L1B16_03600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L1B16_03610	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L1B16_03615	COG1137	ATPase activity
L1B16_03630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1B16_03650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1B16_03655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L1B16_03660	COG2239	Acts as a magnesium transporter
L1B16_03670	COG1294	oxidase, subunit
L1B16_03675	COG1271	oxidase subunit
L1B16_03690	COG1113	amino acid transport
L1B16_03705	COG2197	response regulator
L1B16_03710	COG0531	amino acid
L1B16_03750	COG2814	Major facilitator Superfamily
L1B16_03755	COG0754	glutathionylspermidine amidase activity
L1B16_03780	COG1842	Phage shock protein A
L1B16_03800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L1B16_03805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L1B16_03815	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L1B16_03820	COG0477	Major facilitator Superfamily
L1B16_03830	COG0784	Response regulator, receiver
L1B16_03830	COG2205	protein histidine kinase activity
L1B16_03830	COG2198	Histidine kinase
L1B16_03835	COG2353	YceI-like domain
L1B16_03840	COG3038	cytochrome b561
L1B16_03855	COG1760	l-serine dehydratase
L1B16_03865	COG0527	aspartate kinase activity
L1B16_03865	COG0460	homoserine dehydrogenase
L1B16_03870	COG0626	cystathionine gamma-synthase activity
L1B16_03875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1B16_03880	COG0739	heme binding
L1B16_03885	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L1B16_03890	COG1272	protein, Hemolysin III
L1B16_03895	COG2982	Protein involved in outer membrane biogenesis
L1B16_03900	COG0517	IMP dehydrogenase activity
L1B16_03900	COG0516	GMP reductase activity
L1B16_03905	COG0463	Glycosyl transferase, family 2
L1B16_03910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1B16_03915	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L1B16_03925	COG4771	TonB-dependent receptor
L1B16_03930	COG1309	transcriptional regulator
L1B16_03940	COG1960	acyl-CoA dehydrogenase activity
L1B16_03970	COG0509	glycine decarboxylation via glycine cleavage system
L1B16_03975	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L1B16_03985	COG0330	HflC and HflK could
L1B16_03990	COG1742	UPF0060 membrane protein
L1B16_03995	COG3956	TIGRFAM MazG family protein
L1B16_04005	COG0494	nUDIX hydrolase
L1B16_04015	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L1B16_04020	COG0837	glucose binding
L1B16_04035	COG3858	chitin binding
L1B16_04035	COG1388	LysM domain
L1B16_04040	COG3525	Glycosyl hydrolase, family 20, catalytic domain
L1B16_04050	COG1472	Belongs to the glycosyl hydrolase 3 family
L1B16_04065	COG0531	amino acid
L1B16_04075	COG1486	melibiose metabolic process
L1B16_04085	COG3537	Alpha-1,2-mannosidase
L1B16_04125	COG3645	SOS response
L1B16_04145	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L1B16_04175	COG3142	Participates in the control of copper homeostasis
L1B16_04180	COG1446	asparaginase
L1B16_04185	COG2304	oxidoreductase activity
L1B16_04190	COG1595	DNA-templated transcription, initiation
L1B16_04215	COG0643	Histidine kinase
L1B16_04215	COG0784	Response regulator, receiver
L1B16_04215	COG2198	Histidine kinase
L1B16_04220	COG0840	transmembrane signaling receptor activity
L1B16_04225	COG0835	chemotaxis
L1B16_04240	COG0189	ligase activity
L1B16_04250	COG1397	ADP-ribosylglycohydrolase
L1B16_04260	COG1199	ATP-dependent helicase activity
L1B16_04270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1B16_04275	COG1215	transferase activity, transferring glycosyl groups
L1B16_04285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L1B16_04295	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L1B16_04300	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
L1B16_04325	COG0837	glucose binding
L1B16_04340	COG1643	Atp-dependent helicase
L1B16_04345	COG0783	Belongs to the Dps family
L1B16_04350	COG0514	ATP-dependent DNA helicase (RecQ)
L1B16_04370	COG1187	pseudouridine synthase activity
L1B16_04380	COG0840	transmembrane signaling receptor activity
L1B16_04400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L1B16_04420	COG0667	Aldo Keto reductase
L1B16_04425	COG0602	queuosine metabolic process
L1B16_04435	COG2885	chlorophyll binding
L1B16_04440	COG0823	Involved in the tonB-independent uptake of proteins
L1B16_04450	COG0848	biopolymer transport protein
L1B16_04460	COG0824	Thioesterase
L1B16_04465	COG2255	four-way junction helicase activity
L1B16_04520	COG0477	Major facilitator Superfamily
L1B16_04555	COG0488	(ABC) transporter
L1B16_04620	COG4772	TonB-dependent receptor
L1B16_04630	COG4264	IucA IucC family
L1B16_04635	COG2814	Major facilitator Superfamily
L1B16_04640	COG4264	IucA IucC family
L1B16_04645	COG0019	diaminopimelate decarboxylase activity
L1B16_04670	COG4206	TonB-dependent receptor
L1B16_04680	COG0542	response to heat
L1B16_04685	COG1116	anion transmembrane transporter activity
L1B16_04690	COG1116	anion transmembrane transporter activity
L1B16_04695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1B16_04700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L1B16_04705	COG0667	Aldo Keto reductase
L1B16_04710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1B16_04715	COG4771	TonB-dependent receptor
L1B16_04760	COG1877	trehalose-phosphatase activity
L1B16_04765	COG3387	PFAM Glycoside hydrolase 15-related
L1B16_04780	COG0840	transmembrane signaling receptor activity
L1B16_04790	COG1496	oxidoreductase activity
L1B16_04795	COG0564	pseudouridine synthase activity
L1B16_04800	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L1B16_04810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L1B16_04810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L1B16_04820	COG0045	succinate-CoA ligase (ADP-forming) activity
L1B16_04850	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L1B16_04870	COG0745	RESPONSE REGULATOR receiver
L1B16_04880	COG0189	ligase activity
L1B16_04955	COG0270	DNA (cytosine-5-)-methyltransferase activity
L1B16_05180	COG5001	Diguanylate cyclase
L1B16_05330	COG0583	DNA-binding transcription factor activity
L1B16_05335	COG1396	sequence-specific DNA binding
L1B16_05355	COG0582	viral genome integration into host DNA
L1B16_05385	COG0471	metal ion transport
L1B16_05385	COG3273	potassium ion transport
L1B16_05405	COG1970	mechanosensitive ion channel activity
L1B16_05415	COG1609	Transcriptional regulator
L1B16_05430	COG4948	Mandelate Racemase Muconate Lactonizing
L1B16_05440	COG2272	Belongs to the type-B carboxylesterase lipase family
L1B16_05445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1B16_05470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L1B16_05475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_05480	COG2895	sulfate adenylyltransferase (ATP) activity
L1B16_05480	COG0529	Catalyzes the synthesis of activated sulfate
L1B16_05490	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L1B16_05495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L1B16_05500	COG0175	sulfate reduction
L1B16_05520	COG2198	Histidine kinase
L1B16_05520	COG0784	Response regulator, receiver
L1B16_05520	COG2205	protein histidine kinase activity
L1B16_05535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L1B16_05535	COG1648	precorrin-2 dehydrogenase activity
L1B16_05550	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
L1B16_05555	COG3588	fructose-bisphosphate aldolase
L1B16_05560	COG0469	pyruvate kinase activity
L1B16_05590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L1B16_05605	COG3047	cAMP biosynthetic process
L1B16_05615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1B16_05615	COG3453	Protein conserved in bacteria
L1B16_05620	COG0725	ABC transporter, periplasmic molybdate-binding protein
L1B16_05625	COG4149	molybdate abc transporter
L1B16_05630	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L1B16_05675	COG1376	ErfK ybiS ycfS ynhG family protein
L1B16_05680	COG0739	heme binding
L1B16_05685	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_05690	COG0583	DNA-binding transcription factor activity
L1B16_05695	COG4773	Receptor
L1B16_05700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L1B16_05705	COG1301	dicarboxylic acid transport
L1B16_05735	COG0714	Associated with various cellular activities
L1B16_05765	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L1B16_05790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L1B16_05800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L1B16_05815	COG1561	YicC-like family, N-terminal region
L1B16_05820	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L1B16_05835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L1B16_05850	COG0006	proline dipeptidase activity
L1B16_05860	COG0006	proline dipeptidase activity
L1B16_05885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L1B16_05905	COG2912	Transglutaminase-like superfamily
L1B16_05915	COG1773	rubredoxin
L1B16_05920	COG0352	thiamine-phosphate diphosphorylase activity
L1B16_05930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L1B16_05945	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
L1B16_05950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L1B16_05980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L1B16_06000	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_06010	COG0671	phosphoesterase, PA-phosphatase related
L1B16_06015	COG3781	membrane
L1B16_06025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L1B16_06030	COG0563	adenylate kinase activity
L1B16_06045	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
L1B16_06055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L1B16_06075	COG3710	Transcriptional regulator
L1B16_06080	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L1B16_06090	COG0823	Involved in the tonB-independent uptake of proteins
L1B16_06090	COG4946	Tricorn protease homolog
L1B16_06090	COG1506	peptidase
L1B16_06100	COG0405	Gamma-glutamyltransferase
L1B16_06105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L1B16_06125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L1B16_06130	COG0473	3-isopropylmalate dehydrogenase activity
L1B16_06145	COG0066	3-isopropylmalate dehydratase activity
L1B16_06150	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L1B16_06170	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L1B16_06175	COG1538	Outer membrane efflux protein
L1B16_06180	COG1519	Transferase
L1B16_06185	COG1560	Kdo2-lipid A biosynthetic process
L1B16_06210	COG0281	malic enzyme
L1B16_06210	COG0280	phosphate acetyltransferase
L1B16_06225	COG4191	Histidine kinase
L1B16_06240	COG0583	DNA-binding transcription factor activity
L1B16_06255	COG0667	Aldo Keto reductase
L1B16_06260	COG2197	response regulator
L1B16_06270	COG0642	Histidine kinase
L1B16_06285	COG2851	Citrate transporter
L1B16_06290	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_06295	COG1609	Transcriptional regulator
L1B16_06300	COG2211	Major facilitator Superfamily
L1B16_06385	COG4773	Receptor
L1B16_06390	COG0726	polysaccharide deacetylase
L1B16_06395	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L1B16_06410	COG3964	amidohydrolase
L1B16_06415	COG1228	amidohydrolase
L1B16_06460	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L1B16_06465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L1B16_06490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1B16_06490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1B16_06505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L1B16_06515	COG0488	(ABC) transporter
L1B16_06520	COG0242	peptide deformylase activity
L1B16_06585	COG2188	Transcriptional regulator
L1B16_06595	COG1450	Type ii and iii secretion system protein
L1B16_06610	COG3166	PFAM Fimbrial assembly family protein
L1B16_06615	COG3156	type II secretion system protein K
L1B16_06620	COG4795	General secretion pathway protein
L1B16_06625	COG2165	general secretion pathway protein
L1B16_06630	COG4970	Tfp pilus assembly protein FimT
L1B16_06635	COG2165	general secretion pathway protein
L1B16_06640	COG1459	type II secretion system
L1B16_06645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L1B16_06650	COG1404	Belongs to the peptidase S8 family
L1B16_06660	COG1404	Belongs to the peptidase S8 family
L1B16_06665	COG5295	Hep Hag repeat protein
L1B16_06670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L1B16_06670	COG0047	phosphoribosylformylglycinamidine synthase activity
L1B16_06675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L1B16_06680	COG4974	Belongs to the 'phage' integrase family
L1B16_06690	COG0795	lipopolysaccharide-transporting ATPase activity
L1B16_06710	COG0525	valine-tRNA ligase activity
L1B16_06735	COG1183	phosphatidylcholine synthase activity
L1B16_06745	COG0442	prolyl-tRNA aminoacylation
L1B16_06760	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L1B16_06765	COG1127	ABC transporter
L1B16_06770	COG3218	ABC-type transport auxiliary lipoprotein component
L1B16_06770	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L1B16_06800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L1B16_06805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L1B16_06810	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
L1B16_06810	COG0662	Cupin 2, conserved barrel domain protein
L1B16_06835	COG2086	electron transfer activity
L1B16_06850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L1B16_06850	COG0546	phosphoglycolate phosphatase activity
L1B16_06855	COG0277	FAD linked oxidase domain protein
L1B16_06860	COG0300	oxidoreductase activity
L1B16_06865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L1B16_06905	COG0438	transferase activity, transferring glycosyl groups
L1B16_06905	COG1216	Glycosyl transferase, family 2
L1B16_06925	COG0626	cystathionine gamma-synthase activity
L1B16_06955	COG0625	glutathione transferase activity
L1B16_06965	COG0513	Belongs to the DEAD box helicase family
L1B16_06985	COG4771	TonB-dependent receptor
L1B16_06990	COG0720	synthase
L1B16_07000	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
L1B16_07005	COG1956	GAF domain-containing protein
L1B16_07015	COG2819	hydrolase of the alpha beta superfamily
L1B16_07025	COG0546	phosphoglycolate phosphatase activity
L1B16_07030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L1B16_07045	COG0339	signal peptide processing
L1B16_07090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L1B16_07095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_07100	COG1136	(ABC) transporter
L1B16_07125	COG4191	Histidine kinase
L1B16_07135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L1B16_07150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L1B16_07170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L1B16_07175	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L1B16_07185	COG0356	it plays a direct role in the translocation of protons across the membrane
L1B16_07210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L1B16_07220	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1B16_07255	COG2011	ABC-type metal ion transport system permease component
L1B16_07260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L1B16_07265	COG0697	spore germination
L1B16_07270	COG1666	GTP binding
L1B16_07280	COG5002	protein histidine kinase activity
L1B16_07280	COG2198	Histidine kinase
L1B16_07280	COG0784	Response regulator, receiver
L1B16_07300	COG1187	pseudouridine synthase activity
L1B16_07325	COG2202	Pas domain
L1B16_07325	COG2205	protein histidine kinase activity
L1B16_07345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L1B16_07350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1B16_07400	COG0842	Transport permease protein
L1B16_07405	COG1131	(ABC) transporter
L1B16_07410	COG0025	NhaP-type Na H and K H
L1B16_07420	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
L1B16_07425	COG1573	uracil-dna glycosylase
L1B16_07435	COG3384	dioxygenase
L1B16_07445	COG0583	DNA-binding transcription factor activity
L1B16_07455	COG0667	Aldo Keto reductase
L1B16_07465	COG3590	peptidase
L1B16_07480	COG0531	amino acid
L1B16_07495	COG2972	Histidine kinase
L1B16_07515	COG3685	Protein conserved in bacteria
L1B16_07520	COG3546	catalase activity
L1B16_07545	COG2204	response regulator
L1B16_07555	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_07580	COG1063	alcohol dehydrogenase
L1B16_07605	COG0583	DNA-binding transcription factor activity
L1B16_07610	COG2814	Major facilitator Superfamily
L1B16_07650	COG1131	(ABC) transporter
L1B16_07665	COG0251	oxidation-reduction process
L1B16_07680	COG0840	transmembrane signaling receptor activity
L1B16_07715	COG0659	secondary active sulfate transmembrane transporter activity
L1B16_07720	COG0038	chloride channel
L1B16_07775	COG0642	Histidine kinase
L1B16_07785	COG4695	Portal protein
L1B16_07840	COG3179	chitinase
L1B16_07860	COG4191	Histidine kinase
L1B16_07860	COG0784	Response regulator, receiver
L1B16_07895	COG0456	acetyltransferase
L1B16_07950	COG3081	Nucleoid-associated protein
L1B16_08040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L1B16_08045	COG1490	D-aminoacyl-tRNA deacylase activity
L1B16_08050	COG1560	Kdo2-lipid A biosynthetic process
L1B16_08060	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1B16_08075	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L1B16_08095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L1B16_08095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L1B16_08105	COG0242	peptide deformylase activity
L1B16_08110	COG1652	LysM domain
L1B16_08115	COG0758	DNA mediated transformation
L1B16_08135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L1B16_08135	COG1754	DNA topoisomerase type I activity
L1B16_08140	COG0009	L-threonylcarbamoyladenylate synthase
L1B16_08155	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_08165	COG0616	signal peptide processing
L1B16_08170	COG0534	Mate efflux family protein
L1B16_08185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L1B16_08190	COG0625	glutathione transferase activity
L1B16_08205	COG1252	NADH dehydrogenase
L1B16_08210	COG2860	membrane
L1B16_08215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L1B16_08220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L1B16_08225	COG2201	protein-glutamate methylesterase activity
L1B16_08230	COG2177	Part of the ABC transporter FtsEX involved in
L1B16_08235	COG2884	Cell division ATP-binding protein ftsE
L1B16_08245	COG3118	belongs to the thioredoxin family
L1B16_08250	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L1B16_08260	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
L1B16_08280	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L1B16_08280	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L1B16_08285	COG1473	amidohydrolase
L1B16_08295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L1B16_08305	COG5383	Protein conserved in bacteria
L1B16_08345	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
L1B16_08350	COG3023	N-Acetylmuramoyl-L-alanine amidase
L1B16_08360	COG4948	Mandelate Racemase Muconate Lactonizing
L1B16_08370	COG0531	amino acid
L1B16_08385	COG4682	membrane
L1B16_08390	COG2133	pyrroloquinoline quinone binding
L1B16_08400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L1B16_08415	COG1610	YqeY-like protein
L1B16_08420	COG1295	ribonuclease BN
L1B16_08425	COG0358	DNA primase activity
L1B16_08445	COG0109	protoheme IX farnesyltransferase activity
L1B16_08475	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
L1B16_08490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L1B16_08535	COG0739	heme binding
L1B16_08550	COG2211	Major facilitator Superfamily
L1B16_08555	COG0708	Exodeoxyribonuclease III
L1B16_08570	COG1192	Involved in chromosome partitioning
L1B16_08575	COG1475	DNA binding
L1B16_08595	COG0463	Glycosyl transferase, family 2
L1B16_08620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L1B16_08630	COG0018	arginyl-trna synthetase
L1B16_08645	COG4221	oxidoreductase activity
L1B16_08650	COG2755	lipolytic protein G-D-S-L family
L1B16_08650	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
L1B16_08660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L1B16_08660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L1B16_08665	COG1166	arginine decarboxylase activity
L1B16_08670	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L1B16_08700	COG2960	long-chain fatty acid transporting porin activity
L1B16_08735	COG0210	DNA helicase
L1B16_08785	COG4943	cyclic-guanylate-specific phosphodiesterase activity
L1B16_08835	COG1090	epimerase
L1B16_08845	COG0642	Histidine kinase
L1B16_08885	COG0628	permease
L1B16_08890	COG1011	Hydrolase
L1B16_08895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L1B16_08925	COG2197	response regulator
L1B16_08930	COG4585	Histidine kinase
L1B16_08935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_08940	COG1136	(ABC) transporter
L1B16_08965	COG0697	spore germination
L1B16_08980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1B16_08985	COG0180	Tryptophanyl-tRNA synthetase
L1B16_08990	COG3237	CsbD-like
L1B16_09030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L1B16_09045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L1B16_09050	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L1B16_09050	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L1B16_09090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L1B16_09115	COG1199	ATP-dependent helicase activity
L1B16_09210	COG4555	ABC transporter
L1B16_09220	COG1476	TRANSCRIPTIONal
L1B16_09255	COG1131	(ABC) transporter
L1B16_09260	COG0842	Transport permease protein
L1B16_09265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L1B16_09275	COG1607	acyl-coa hydrolase
L1B16_09290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1B16_09295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1B16_09305	COG1042	CoA-binding domain protein
L1B16_09305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L1B16_09305	COG0045	succinate-CoA ligase (ADP-forming) activity
L1B16_09310	COG2239	Acts as a magnesium transporter
L1B16_09320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L1B16_09325	COG3387	PFAM Glycoside hydrolase 15-related
L1B16_09340	COG3100	YcgL domain-containing protein
L1B16_09345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L1B16_09370	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_09400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L1B16_09415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L1B16_09500	COG0210	DNA helicase
L1B16_09510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L1B16_09515	COG0583	DNA-binding transcription factor activity
L1B16_09520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L1B16_09530	COG2159	amidohydrolase
L1B16_09550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_09570	COG0357	Ribosomal RNA small subunit methyltransferase G
L1B16_09575	COG3540	Alkaline phosphatase
L1B16_09585	COG2091	lysine biosynthetic process via aminoadipic acid
L1B16_09605	COG1940	carbohydrate kinase activity
L1B16_09615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L1B16_09625	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1B16_09670	COG3507	Belongs to the glycosyl hydrolase 43 family
L1B16_09685	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_09690	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1B16_09695	COG4948	Mandelate Racemase Muconate Lactonizing
L1B16_09700	COG3254	rhamnose metabolic process
L1B16_09705	COG0738	Major facilitator superfamily
L1B16_09710	COG1414	Transcriptional regulator
L1B16_09715	COG1971	Probably functions as a manganese efflux pump
L1B16_09720	COG0784	Response regulator, receiver
L1B16_09720	COG2205	protein histidine kinase activity
L1B16_09725	COG3459	Glycosyltransferase 36 associated
L1B16_09730	COG2211	Major facilitator Superfamily
L1B16_09735	COG3265	gluconokinase activity
L1B16_09740	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L1B16_09760	COG2911	Protein conserved in bacteria
L1B16_09765	COG0729	surface antigen
L1B16_09770	COG4771	TonB-dependent receptor
L1B16_09775	COG0457	Tetratricopeptide repeat
L1B16_09790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L1B16_09795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L1B16_09795	COG0519	Catalyzes the synthesis of GMP from XMP
L1B16_09805	COG0805	protein transport
L1B16_09810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L1B16_09815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L1B16_09825	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L1B16_09840	COG2974	May be involved in recombination
L1B16_09845	COG0037	tRNA processing
L1B16_09860	COG3661	Belongs to the glycosyl hydrolase 67 family
L1B16_09870	COG4948	Mandelate Racemase Muconate Lactonizing
L1B16_09880	COG1472	Belongs to the glycosyl hydrolase 3 family
L1B16_09885	COG0246	Mannitol dehydrogenase
L1B16_09910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L1B16_09940	COG3250	beta-galactosidase activity
L1B16_09945	COG1904	glucuronate isomerase
L1B16_09965	COG2211	Major facilitator Superfamily
L1B16_10015	COG0604	alcohol dehydrogenase
L1B16_10015	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_10015	COG3321	synthase
L1B16_10020	COG2937	Belongs to the GPAT DAPAT family
L1B16_10050	COG0284	orotidine-5'-phosphate decarboxylase activity
L1B16_10055	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
L1B16_10060	COG3132	Protein of unknown function, DUF480
L1B16_10075	COG0210	DNA helicase
L1B16_10080	COG1435	thymidine kinase activity
L1B16_10090	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
L1B16_10100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L1B16_10130	COG3135	benzoate transporter
L1B16_10155	COG0676	glucose-6-phosphate 1-epimerase activity
L1B16_10185	COG0730	response to heat
L1B16_10210	COG0302	gtp cyclohydrolase
L1B16_10225	COG1566	PFAM secretion protein HlyD family protein
L1B16_10235	COG1289	transmembrane transporter activity
L1B16_10240	COG0477	Major facilitator Superfamily
L1B16_10250	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
L1B16_10255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L1B16_10325	COG0564	pseudouridine synthase activity
L1B16_10355	COG3549	Plasmid maintenance system killer
L1B16_10360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L1B16_10365	COG1074	ATP-dependent DNA helicase activity
L1B16_10370	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L1B16_10405	COG1127	ABC transporter
L1B16_10410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L1B16_10415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L1B16_10430	COG2853	Lipoprotein
L1B16_10440	COG0386	Belongs to the glutathione peroxidase family
L1B16_10450	COG1322	Protein conserved in bacteria
L1B16_10460	COG0531	amino acid
L1B16_10465	COG3537	Alpha-1,2-mannosidase
L1B16_10480	COG3706	GGDEF domain
L1B16_10485	COG3835	regulator
L1B16_10490	COG1929	Belongs to the glycerate kinase type-1 family
L1B16_10495	COG2271	Major facilitator Superfamily
L1B16_10545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L1B16_10550	COG0861	Integral membrane protein TerC family
L1B16_10560	COG0584	glycerophosphoryl diester phosphodiesterase
L1B16_10570	COG0671	phosphoesterase, PA-phosphatase related
L1B16_10575	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L1B16_10580	COG0726	polysaccharide deacetylase
L1B16_10585	COG0706	membrane insertase activity
L1B16_10600	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L1B16_10615	COG0187	DNA topoisomerase II activity
L1B16_10625	COG0501	Belongs to the peptidase M48B family
L1B16_10660	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L1B16_10670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L1B16_10700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L1B16_10705	COG0793	Belongs to the peptidase S41A family
L1B16_10710	COG4942	peptidase
L1B16_10720	COG2234	aminopeptidase activity
L1B16_10730	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L1B16_10735	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L1B16_10740	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L1B16_10745	COG1064	alcohol dehydrogenase
L1B16_10755	COG0493	'glutamate synthase
L1B16_10760	COG0067	glutamate synthase
L1B16_10760	COG0069	glutamate synthase activity
L1B16_10760	COG0070	glutamate synthase
L1B16_10795	COG3459	Glycosyltransferase 36 associated
L1B16_10845	COG1111	helicase
L1B16_10845	COG1205	dead DEAH box helicase
L1B16_10850	COG1272	protein, Hemolysin III
L1B16_10890	COG0583	DNA-binding transcription factor activity
L1B16_10895	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_10910	COG1733	regulation of RNA biosynthetic process
L1B16_10940	COG3237	CsbD-like
L1B16_10975	COG0657	acetylesterase activity
L1B16_10985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L1B16_11030	COG1309	transcriptional regulator
L1B16_11055	COG4772	TonB-dependent receptor
L1B16_11065	COG2423	ornithine cyclodeaminase activity
L1B16_11075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1B16_11080	COG0765	amino acid transport
L1B16_11090	COG3284	Transcriptional regulator
L1B16_11095	COG1012	belongs to the aldehyde dehydrogenase family
L1B16_11125	COG1304	FMN binding
L1B16_11130	COG1755	Isoprenylcysteine carboxyl methyltransferase
L1B16_11135	COG4585	Histidine kinase
L1B16_11160	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L1B16_11240	COG1595	DNA-templated transcription, initiation
L1B16_11280	COG0366	Alpha amylase catalytic
L1B16_11285	COG0366	Alpha amylase catalytic
L1B16_11290	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L1B16_11335	COG0657	acetylesterase activity
L1B16_11335	COG2755	lipolytic protein G-D-S-L family
L1B16_11345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L1B16_11360	COG3507	Belongs to the glycosyl hydrolase 43 family
L1B16_11365	COG1609	Transcriptional regulator
L1B16_11370	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
L1B16_11375	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_11385	COG2755	lipolytic protein G-D-S-L family
L1B16_11395	COG3186	Phenylalanine-4-hydroxylase
L1B16_11400	COG1522	sequence-specific DNA binding
L1B16_11410	COG1752	Esterase of the alpha-beta hydrolase superfamily
L1B16_11420	COG1119	ATPase activity
L1B16_11435	COG0517	IMP dehydrogenase activity
L1B16_11435	COG1125	glycine betaine transport
L1B16_11450	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L1B16_11455	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
L1B16_11485	COG0489	protein tyrosine kinase activity
L1B16_11490	COG2062	phosphohistidine phosphatase, SixA
L1B16_11495	COG2353	YceI-like domain
L1B16_11500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L1B16_11525	COG1881	PFAM PEBP family protein
L1B16_11540	COG0174	glutamine synthetase
L1B16_11545	COG0347	Belongs to the P(II) protein family
L1B16_11550	COG0004	ammonium transporteR
L1B16_11555	COG3852	Histidine kinase
L1B16_11560	COG2204	response regulator
L1B16_11565	COG2032	superoxide dismutase activity
L1B16_11570	COG2032	superoxide dismutase activity
L1B16_11585	COG0183	Belongs to the thiolase family
L1B16_11625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L1B16_11635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L1B16_11645	COG0028	Belongs to the TPP enzyme family
L1B16_11650	COG2205	protein histidine kinase activity
L1B16_11675	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L1B16_11690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1B16_11695	COG3177	Filamentation induced by cAMP protein fic
L1B16_11710	COG0596	Alpha beta hydrolase
L1B16_11715	COG0727	PFAM Uncharacterised protein family (UPF0153)
L1B16_11720	COG0318	PFAM AMP-dependent synthetase and ligase
L1B16_11725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L1B16_11740	COG1181	Belongs to the D-alanine--D-alanine ligase family
L1B16_11760	COG0564	pseudouridine synthase activity
L1B16_11780	COG1446	asparaginase
L1B16_11785	COG0339	signal peptide processing
L1B16_11790	COG0681	Belongs to the peptidase S26 family
L1B16_11815	COG0475	glutathione-regulated potassium exporter activity
L1B16_11820	COG0583	DNA-binding transcription factor activity
L1B16_11825	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L1B16_11830	COG2224	Isocitrate lyase
L1B16_11860	COG4770	biotin carboxylase activity
L1B16_11865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L1B16_11870	COG1960	acyl-CoA dehydrogenase activity
L1B16_11925	COG0523	cobalamin synthesis protein
L1B16_11935	COG0697	spore germination
L1B16_11945	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L1B16_11950	COG1846	Transcriptional regulator
L1B16_11955	COG1764	response to oxidative stress
L1B16_11980	COG0656	L-ascorbic acid biosynthetic process
L1B16_11985	COG2130	NADP-dependent
L1B16_12000	COG1187	pseudouridine synthase activity
L1B16_12010	COG1643	Atp-dependent helicase
L1B16_12015	COG0840	transmembrane signaling receptor activity
L1B16_12020	COG4807	Protein conserved in bacteria
L1B16_12025	COG2351	hydroxyisourate hydrolase activity
L1B16_12030	COG2072	flavoprotein involved in K transport
L1B16_12050	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L1B16_12100	COG1957	nucleoside hydrolase
L1B16_12125	COG0084	hydrolase, TatD family'
L1B16_12140	COG0583	DNA-binding transcription factor activity
L1B16_12145	COG2814	Major facilitator Superfamily
L1B16_12150	COG1404	Belongs to the peptidase S8 family
L1B16_12170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L1B16_12175	COG1902	pentaerythritol trinitrate reductase activity
L1B16_12195	COG2223	nitrite transmembrane transporter activity
L1B16_12200	COG0745	RESPONSE REGULATOR receiver
L1B16_12215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_12235	COG0577	efflux transmembrane transporter activity
L1B16_12240	COG0577	efflux transmembrane transporter activity
L1B16_12240	COG1136	(ABC) transporter
L1B16_12290	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L1B16_12295	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L1B16_12300	COG0583	DNA-binding transcription factor activity
L1B16_12325	COG0702	epimerase
L1B16_12330	COG1733	regulation of RNA biosynthetic process
L1B16_12340	COG0840	transmembrane signaling receptor activity
L1B16_12385	COG0129	dihydroxy-acid dehydratase activity
L1B16_12405	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L1B16_12460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L1B16_12490	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L1B16_12495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L1B16_12505	COG3485	protocatechuate 3,4-dioxygenase
L1B16_12510	COG3485	protocatechuate 3,4-dioxygenase
L1B16_12520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1B16_12525	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L1B16_12535	COG1414	Transcriptional regulator
L1B16_12555	COG0445	tRNA wobble uridine modification
L1B16_12565	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L1B16_12605	COG0156	8-amino-7-oxononanoate synthase activity
L1B16_12610	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L1B16_12615	COG1040	competence protein
L1B16_12620	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L1B16_12685	COG4771	TonB-dependent receptor
L1B16_12710	COG1169	isochorismate synthase
L1B16_12740	COG2226	methyltransferase
L1B16_12740	COG3433	isochorismatase activity
L1B16_12740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L1B16_12755	COG4771	TonB-dependent receptor
L1B16_12760	COG2375	cellular response to nickel ion
L1B16_12760	COG1132	(ABC) transporter
L1B16_12765	COG1132	(ABC) transporter
L1B16_12795	COG3264	Mechanosensitive ion channel
L1B16_12795	COG1511	domain protein
L1B16_12800	COG1368	sulfuric ester hydrolase activity
L1B16_12805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L1B16_12810	COG2354	Protein conserved in bacteria
L1B16_12820	COG0297	glycogen (starch) synthase activity
L1B16_12825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L1B16_12830	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L1B16_12855	COG0702	epimerase
L1B16_12860	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_12900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L1B16_12905	COG4221	oxidoreductase activity
L1B16_12920	COG0513	Belongs to the DEAD box helicase family
L1B16_12930	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1B16_12945	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L1B16_12960	COG3104	oligopeptide transport
L1B16_12980	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
L1B16_12995	COG1320	monovalent cation:proton antiporter activity
L1B16_13000	COG2212	antiporter activity
L1B16_13010	COG0651	ATP synthesis coupled electron transport
L1B16_13015	COG1006	Multisubunit Na H antiporter MnhC subunit
L1B16_13020	COG2111	Na H antiporter
L1B16_13020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L1B16_13065	COG0484	heat shock protein binding
L1B16_13085	COG1597	lipid kinase activity
L1B16_13105	COG0583	DNA-binding transcription factor activity
L1B16_13110	COG0583	DNA-binding transcription factor activity
L1B16_13115	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
L1B16_13125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1B16_13210	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L1B16_13290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L1B16_13295	COG0134	indole-3-glycerol-phosphate synthase activity
L1B16_13305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L1B16_13320	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
L1B16_13330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L1B16_13345	COG1051	belongs to the nudix hydrolase family
L1B16_13385	COG0316	Belongs to the HesB IscA family
L1B16_13400	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
L1B16_13425	COG2814	Major facilitator Superfamily
L1B16_13430	COG1289	transmembrane transporter activity
L1B16_13435	COG0151	Belongs to the GarS family
L1B16_13440	COG0138	bifunctional purine biosynthesis protein purh
L1B16_13460	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L1B16_13480	COG2264	protein methyltransferase activity
L1B16_13495	COG0439	Biotin carboxylase
L1B16_13505	COG0511	ligase activity, forming carbon-carbon bonds
L1B16_13510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L1B16_13525	COG1324	tolerance protein
L1B16_13530	COG2356	endonuclease I
L1B16_13560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L1B16_13585	COG3712	iron ion homeostasis
L1B16_13610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L1B16_13640	COG2353	YceI-like domain
L1B16_13660	COG3052	prosthetic group binding
L1B16_13695	COG1802	Transcriptional regulator
L1B16_13700	COG0546	phosphoglycolate phosphatase activity
L1B16_13795	COG1595	DNA-templated transcription, initiation
L1B16_13810	COG4206	TonB-dependent receptor
L1B16_13815	COG0823	Involved in the tonB-independent uptake of proteins
L1B16_13815	COG1506	peptidase
L1B16_13870	COG0435	Glutathione S-transferase
L1B16_13905	COG0823	Involved in the tonB-independent uptake of proteins
L1B16_13905	COG1506	peptidase
L1B16_13955	COG0697	spore germination
L1B16_13975	COG1113	amino acid transport
L1B16_14035	COG0840	transmembrane signaling receptor activity
L1B16_14040	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L1B16_14040	COG5297	Belongs to the glycosyl hydrolase family 6
L1B16_14045	COG0659	secondary active sulfate transmembrane transporter activity
L1B16_14060	COG2943	transferase activity, transferring hexosyl groups
L1B16_14080	COG0181	hydroxymethylbilane synthase activity
L1B16_14105	COG1505	serine-type exopeptidase activity
L1B16_14110	COG0436	Aminotransferase
L1B16_14120	COG2832	Protein of unknown function (DUF454)
L1B16_14130	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L1B16_14145	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
L1B16_14175	COG2226	methyltransferase
L1B16_14180	COG3300	MHYT domain
L1B16_14180	COG5001	Diguanylate cyclase
L1B16_14185	COG0308	aminopeptidase N
L1B16_14220	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L1B16_14230	COG3284	Transcriptional regulator
L1B16_14235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L1B16_14240	COG1077	Cell shape determining protein MreB Mrl
L1B16_14250	COG1792	Involved in formation and maintenance of cell shape
L1B16_14265	COG0772	Belongs to the SEDS family
L1B16_14275	COG2951	lytic endotransglycosylase activity
L1B16_14280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L1B16_14285	COG1686	Belongs to the peptidase S11 family
L1B16_14295	COG2921	Belongs to the UPF0250 family
L1B16_14300	COG0321	lipoyl(octanoyl) transferase activity
L1B16_14305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L1B16_14320	COG0583	DNA-binding transcription factor activity
L1B16_14330	COG1051	belongs to the nudix hydrolase family
L1B16_14330	COG1056	cytidyltransferase-related domain
L1B16_14345	COG2813	Specifically methylates the guanine in position
L1B16_14365	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L1B16_14370	COG0673	inositol 2-dehydrogenase activity
L1B16_14375	COG2823	Periplasmic or secreted lipoprotein
L1B16_14380	COG4251	negative regulation of phosphorylation
L1B16_14385	COG0784	Response regulator, receiver
L1B16_14390	COG4191	Histidine kinase
L1B16_14395	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L1B16_14400	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_14445	COG1459	type II secretion system
L1B16_14495	COG3250	beta-galactosidase activity
L1B16_14510	COG2188	Transcriptional regulator
L1B16_14520	COG1609	Transcriptional regulator
L1B16_14525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L1B16_14530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L1B16_14545	COG0617	tRNA 3'-terminal CCA addition
L1B16_14560	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
L1B16_14565	COG1012	belongs to the aldehyde dehydrogenase family
L1B16_14570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L1B16_14580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L1B16_14595	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L1B16_14600	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L1B16_14615	COG2205	protein histidine kinase activity
L1B16_14635	COG3920	Histidine kinase
L1B16_14650	COG3791	Glutathione-dependent formaldehyde-activating
L1B16_14660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1B16_14670	COG0697	spore germination
L1B16_14690	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L1B16_14695	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L1B16_14700	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
L1B16_14705	COG2205	protein histidine kinase activity
L1B16_14710	COG0745	RESPONSE REGULATOR receiver
L1B16_14715	COG4946	Tricorn protease homolog
L1B16_14715	COG1506	peptidase
L1B16_14715	COG0823	Involved in the tonB-independent uptake of proteins
L1B16_14720	COG0277	FAD linked oxidase domain protein
L1B16_14725	COG1988	membrane-bound metal-dependent
L1B16_14730	COG0792	nuclease activity
L1B16_14765	COG3116	cell division
L1B16_14775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L1B16_14780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L1B16_14800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L1B16_14805	COG1181	Belongs to the D-alanine--D-alanine ligase family
L1B16_14810	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L1B16_14835	COG0739	heme binding
L1B16_14840	COG0653	protein targeting
L1B16_14850	COG0494	nUDIX hydrolase
L1B16_14865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L1B16_14870	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_14870	COG3321	synthase
L1B16_14870	COG0604	alcohol dehydrogenase
L1B16_14890	COG0366	Alpha amylase catalytic
L1B16_14915	COG2226	methyltransferase
L1B16_14930	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L1B16_14960	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L1B16_14975	COG4106	trans-aconitate 2-methyltransferase activity
L1B16_14980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L1B16_14990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L1B16_14995	COG0667	Aldo Keto reductase
L1B16_15005	COG4771	TonB-dependent receptor
L1B16_15025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1B16_15030	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L1B16_15040	COG2175	clavaminate synthase activity
L1B16_15050	COG4181	ATPase activity
L1B16_15065	COG0642	Histidine kinase
L1B16_15075	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L1B16_15095	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L1B16_15100	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L1B16_15110	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L1B16_15115	COG2967	ApaG domain
L1B16_15120	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L1B16_15125	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L1B16_15135	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
L1B16_15140	COG0123	including yeast histone deacetylase and acetoin utilization protein
L1B16_15145	COG2096	Adenosyltransferase
L1B16_15155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1B16_15160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1B16_15190	COG3384	dioxygenase
L1B16_15195	COG0583	DNA-binding transcription factor activity
L1B16_15200	COG0318	PFAM AMP-dependent synthetase and ligase
L1B16_15210	COG1024	Enoyl-CoA hydratase
L1B16_15260	COG0697	spore germination
L1B16_15265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L1B16_15290	COG2197	response regulator
L1B16_15300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L1B16_15310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L1B16_15315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L1B16_15320	COG0583	DNA-binding transcription factor activity
L1B16_15325	COG3634	alkyl hydroperoxide reductase activity
L1B16_15335	COG2890	protein-(glutamine-N5) methyltransferase activity
L1B16_15355	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L1B16_15355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L1B16_15385	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
L1B16_15430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L1B16_15435	COG1404	Belongs to the peptidase S8 family
L1B16_15440	COG1404	Belongs to the peptidase S8 family
L1B16_15445	COG1404	Belongs to the peptidase S8 family
L1B16_15450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L1B16_15470	COG1295	ribonuclease BN
L1B16_15475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L1B16_15480	COG1254	Belongs to the acylphosphatase family
L1B16_15495	COG0521	Mo-molybdopterin cofactor biosynthetic process
L1B16_15505	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L1B16_15510	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L1B16_15520	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L1B16_15535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L1B16_15540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L1B16_15545	COG0193	aminoacyl-tRNA hydrolase activity
L1B16_15550	COG0012	GTP binding
L1B16_15570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L1B16_15580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L1B16_15585	COG0250	Participates in transcription elongation, termination and antitermination
L1B16_15590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L1B16_15595	COG0081	regulation of translation
L1B16_15600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L1B16_15605	COG0222	ribosome binding
L1B16_15615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L1B16_15620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L1B16_15630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L1B16_15635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L1B16_15640	COG0051	transcription antitermination factor activity, RNA binding
L1B16_15660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L1B16_15670	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L1B16_15685	COG0255	Belongs to the universal ribosomal protein uL29 family
L1B16_15700	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L1B16_15720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L1B16_15735	COG1841	ribosomal large subunit assembly
L1B16_15745	COG0201	protein transport
L1B16_15770	COG0203	ribosomal protein L17
L1B16_15780	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
L1B16_15790	COG0154	amidase activity
L1B16_15800	COG1217	gtp-binding protein TYPA
L1B16_15805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L1B16_15815	COG0625	glutathione transferase activity
L1B16_15830	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1B16_15830	COG1902	pentaerythritol trinitrate reductase activity
L1B16_15835	COG0604	alcohol dehydrogenase
L1B16_15840	COG2885	chlorophyll binding
L1B16_15865	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L1B16_15870	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L1B16_15875	COG4208	sulfate ABC transporter
L1B16_15880	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L1B16_15910	COG0406	alpha-ribazole phosphatase activity
L1B16_15920	COG0285	dihydrofolate synthase activity
L1B16_15940	COG2833	Protein of unknown function (DUF455)
L1B16_15945	COG3291	Pkd domain containing protein
L1B16_15955	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L1B16_15960	COG0671	phosphoesterase, PA-phosphatase related
L1B16_15965	COG0438	transferase activity, transferring glycosyl groups
L1B16_15975	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L1B16_15990	COG4783	chaperone-mediated protein folding
L1B16_16005	COG0473	3-isopropylmalate dehydrogenase activity
L1B16_16040	COG0784	Response regulator, receiver
L1B16_16040	COG4191	Histidine kinase
L1B16_16050	COG0544	peptidyl-prolyl cis-trans isomerase activity
L1B16_16060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L1B16_16090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L1B16_16100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1B16_16120	COG0631	protein serine/threonine phosphatase activity
L1B16_16135	COG0859	PFAM glycosyl transferase family 9
L1B16_16145	COG1234	tRNA 3'-trailer cleavage
L1B16_16150	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L1B16_16155	COG0315	cyclic pyranopterin monophosphate synthase activity
L1B16_16160	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
L1B16_16165	COG0314	molybdopterin synthase activity
L1B16_16185	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L1B16_16190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L1B16_16195	COG0537	adenosine 5'-monophosphoramidase activity
L1B16_16215	COG0714	Associated with various cellular activities
L1B16_16235	COG0424	maF-like protein
L1B16_16240	COG1399	metal-binding, possibly nucleic acid-binding protein
L1B16_16245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L1B16_16250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1B16_16260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L1B16_16265	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_16280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L1B16_16285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L1B16_16310	COG3829	transcription factor binding
L1B16_16330	COG3609	addiction module antidote protein, CC2985 family
L1B16_16385	COG4953	penicillin-binding protein 1C
L1B16_16395	COG0678	peroxiredoxin activity
L1B16_16415	COG0330	HflC and HflK could
L1B16_16420	COG0330	HflC and HflK could
L1B16_16435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L1B16_16440	COG0308	aminopeptidase N
L1B16_16460	COG1309	transcriptional regulator
L1B16_16505	COG1309	transcriptional regulator
L1B16_16515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L1B16_16525	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_16535	COG3537	Alpha-1,2-mannosidase
L1B16_16575	COG2323	membrane
L1B16_16590	COG2271	Major facilitator Superfamily
L1B16_16615	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1B16_16620	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L1B16_16625	COG2080	2 iron, 2 sulfur cluster binding
L1B16_16685	COG0587	DNA-directed DNA polymerase activity
L1B16_16695	COG1297	OPT oligopeptide transporter protein
L1B16_16715	COG1506	peptidase
L1B16_16715	COG0823	Involved in the tonB-independent uptake of proteins
L1B16_16730	COG1917	Cupin 2, conserved barrel domain protein
L1B16_16730	COG2207	Transcriptional regulator
L1B16_16735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_16770	COG0753	catalase activity
L1B16_16775	COG0656	L-ascorbic acid biosynthetic process
L1B16_16780	COG2272	Belongs to the type-B carboxylesterase lipase family
L1B16_16785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L1B16_16785	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L1B16_16815	COG2194	sulfuric ester hydrolase activity
L1B16_16825	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L1B16_16830	COG0745	RESPONSE REGULATOR receiver
L1B16_16835	COG5002	protein histidine kinase activity
L1B16_16850	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
L1B16_16855	COG2894	cell division
L1B16_16870	COG4585	Histidine kinase
L1B16_16875	COG2197	response regulator
L1B16_16890	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
L1B16_16925	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
L1B16_16935	COG1595	DNA-templated transcription, initiation
L1B16_16945	COG1946	Acyl-CoA thioesterase
L1B16_16950	COG1024	Enoyl-CoA hydratase
L1B16_16960	COG0824	Thioesterase
L1B16_16965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L1B16_16975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L1B16_16980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L1B16_16990	COG0728	peptidoglycan biosynthetic process
L1B16_16995	COG0196	riboflavin kinase activity
L1B16_17005	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L1B16_17010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L1B16_17025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L1B16_17030	COG1845	cytochrome c oxidase, subunit III
L1B16_17035	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L1B16_17050	COG3152	Membrane
L1B16_17060	COG2207	Transcriptional regulator
L1B16_17065	COG0326	Molecular chaperone. Has ATPase activity
L1B16_17075	COG1902	pentaerythritol trinitrate reductase activity
L1B16_17080	COG1366	Belongs to the anti-sigma-factor antagonist family
L1B16_17085	COG1366	Belongs to the anti-sigma-factor antagonist family
L1B16_17090	COG2172	sigma factor antagonist activity
L1B16_17120	COG4771	TonB-dependent receptor
L1B16_17130	COG5507	3-demethylubiquinone-9 3-methyltransferase
L1B16_17135	COG2205	protein histidine kinase activity
L1B16_17145	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L1B16_17150	COG2205	protein histidine kinase activity
L1B16_17150	COG3437	response regulator, receiver
L1B16_17150	COG3850	Histidine kinase
L1B16_17150	COG4999	Histidine kinase
L1B16_17155	COG0784	Response regulator, receiver
L1B16_17155	COG4191	Histidine kinase
L1B16_17205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L1B16_17210	COG2070	2-Nitropropane dioxygenase
L1B16_17230	COG0336	Belongs to the RNA methyltransferase TrmD family
L1B16_17260	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
L1B16_17270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L1B16_17320	COG3209	COG3209 Rhs family protein
L1B16_17390	COG0840	transmembrane signaling receptor activity
L1B16_17415	COG2814	Major facilitator Superfamily
L1B16_17435	COG2003	Belongs to the UPF0758 family
L1B16_17455	COG0322	excinuclease ABC activity
L1B16_17495	COG3250	beta-galactosidase activity
L1B16_17500	COG3867	Arabinogalactan endo-beta-1,4-galactanase
L1B16_17510	COG1396	sequence-specific DNA binding
L1B16_17510	COG3800	Transcriptional regulator
L1B16_17520	COG1960	acyl-CoA dehydrogenase activity
L1B16_17545	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1B16_17545	COG1024	Enoyl-CoA hydratase
L1B16_17560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L1B16_17565	COG0481	GTPase activity
L1B16_17580	COG0571	ribonuclease III activity
L1B16_17585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L1B16_17590	COG1381	Involved in DNA repair and RecF pathway recombination
L1B16_17605	COG2954	triphosphatase activity
L1B16_17610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L1B16_17615	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
L1B16_17620	COG3046	protein related to deoxyribodipyrimidine photolyase
L1B16_17625	COG1472	Belongs to the glycosyl hydrolase 3 family
L1B16_17630	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L1B16_17635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
L1B16_17640	COG1278	Cold shock
L1B16_17645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1B16_17655	COG1201	RNA secondary structure unwinding
L1B16_17660	COG1793	dna ligase
L1B16_17670	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L1B16_17670	COG1793	dna ligase
L1B16_17700	COG0183	Belongs to the thiolase family
L1B16_17720	COG1451	nucleotide metabolic process
L1B16_17725	COG5487	UPF0391 membrane protein
L1B16_17735	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L1B16_17780	COG1047	Peptidyl-prolyl cis-trans
L1B16_17790	COG2824	Alkylphosphonate utilization operon protein PhnA
L1B16_17810	COG1902	pentaerythritol trinitrate reductase activity
L1B16_17815	COG2814	Major facilitator Superfamily
L1B16_17855	COG0392	lysyltransferase activity
L1B16_17855	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L1B16_17865	COG0251	oxidation-reduction process
L1B16_17870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L1B16_17885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L1B16_17910	COG1595	DNA-templated transcription, initiation
L1B16_17925	COG2878	Part of a membrane complex involved in electron transport
L1B16_17935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1B16_17935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1B16_17955	COG0346	lactoylglutathione lyase activity
L1B16_17975	COG0833	amino acid
L1B16_17980	COG2040	homocysteine
L1B16_18000	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
L1B16_18020	COG1695	Transcriptional regulator
L1B16_18040	COG1981	membrane
L1B16_18050	COG0825	malonyl-CoA metabolic process
L1B16_18065	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L1B16_18070	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L1B16_18080	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L1B16_18095	COG0750	zinc metalloprotease
L1B16_18100	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L1B16_18105	COG0575	Belongs to the CDS family
L1B16_18115	COG0233	cytoplasmic translational termination
L1B16_18120	COG0528	UMP kinase activity
L1B16_18130	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L1B16_18135	COG0052	Belongs to the universal ribosomal protein uS2 family
L1B16_18190	COG1393	Belongs to the ArsC family
L1B16_18195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1B16_18205	COG0367	asparagine synthase
L1B16_18215	COG4774	siderophore transport
L1B16_18255	COG1566	PFAM secretion protein HlyD family protein
L1B16_18260	COG2814	Major facilitator Superfamily
L1B16_18320	COG0339	signal peptide processing
L1B16_18330	COG0386	Belongs to the glutathione peroxidase family
L1B16_18390	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L1B16_18395	COG0084	hydrolase, TatD family'
L1B16_18410	COG1960	acyl-CoA dehydrogenase activity
L1B16_18425	COG0367	asparagine synthase
L1B16_18435	COG0305	Participates in initiation and elongation during chromosome replication
L1B16_18440	COG0415	Belongs to the DNA photolyase family
L1B16_18455	COG0583	DNA-binding transcription factor activity
L1B16_18470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_18505	COG3706	GGDEF domain
L1B16_18545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L1B16_18550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L1B16_18565	COG0494	nUDIX hydrolase
L1B16_18570	COG0433	COG0433 Predicted ATPase
L1B16_18580	COG0688	phosphatidylethanolamine metabolic process
L1B16_18590	COG2890	protein-(glutamine-N5) methyltransferase activity
L1B16_18605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L1B16_18610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L1B16_18625	COG0101	tRNA pseudouridine synthase activity
L1B16_18640	COG0133	tryptophan synthase activity
L1B16_18650	COG0159	tryptophan synthase activity
L1B16_18655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L1B16_18660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L1B16_18690	COG4221	oxidoreductase activity
L1B16_18710	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L1B16_18720	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L1B16_18730	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
L1B16_18735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L1B16_18745	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L1B16_18750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L1B16_18755	COG0839	Belongs to the complex I subunit 6 family
L1B16_18775	COG1007	ATP synthesis coupled electron transport
L1B16_18785	COG0779	Required for maturation of 30S ribosomal subunits
L1B16_18790	COG0195	Participates in both transcription termination and antitermination
L1B16_18800	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L1B16_18805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L1B16_18810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L1B16_18815	COG1185	polyribonucleotide nucleotidyltransferase activity
L1B16_18850	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L1B16_18855	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_18860	COG2095	MarC family integral membrane protein
L1B16_18870	COG1611	Belongs to the LOG family
L1B16_18875	COG3275	phosphorelay sensor kinase activity
L1B16_18920	COG0556	nucleotide-excision repair
L1B16_18935	COG3505	Type IV secretory pathway VirD4
L1B16_18955	COG2948	multi-organism process
L1B16_18975	COG3702	type iv secretory pathway
L1B16_19050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L1B16_19095	COG1082	Xylose isomerase domain protein TIM barrel
L1B16_19105	COG2190	(PTS) system
L1B16_19105	COG2211	Major facilitator Superfamily
L1B16_19120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L1B16_19125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L1B16_19140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L1B16_19145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1B16_19145	COG0072	phenylalanine-tRNA ligase activity
L1B16_19195	COG0438	transferase activity, transferring glycosyl groups
L1B16_19200	COG0438	transferase activity, transferring glycosyl groups
L1B16_19210	COG0438	transferase activity, transferring glycosyl groups
L1B16_19235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1B16_19240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1B16_19245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L1B16_19265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L1B16_19275	COG1960	acyl-CoA dehydrogenase activity
L1B16_19305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L1B16_19315	COG0784	Response regulator, receiver
L1B16_19315	COG4191	Histidine kinase
L1B16_19325	COG1194	a g-specific adenine glycosylase
L1B16_19330	COG0552	protein localization to endoplasmic reticulum
L1B16_19340	COG3938	Belongs to the proline racemase family
L1B16_19345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1B16_19360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1B16_19370	COG0006	proline dipeptidase activity
L1B16_19385	COG0531	amino acid
L1B16_19465	COG0326	Molecular chaperone. Has ATPase activity
L1B16_19470	COG0742	ribosomal rna small subunit methyltransferase
L1B16_19490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L1B16_19500	COG3291	Pkd domain containing protein
L1B16_19540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L1B16_19550	COG1862	Preprotein translocase
L1B16_19560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L1B16_19570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L1B16_19570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L1B16_19575	COG1105	Belongs to the carbohydrate kinase PfkB family
L1B16_19580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L1B16_19580	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1B16_19585	COG1609	Transcriptional regulator
L1B16_19595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L1B16_19600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1B16_19610	COG2902	Dehydrogenase
L1B16_19620	COG3321	synthase
L1B16_19620	COG0604	alcohol dehydrogenase
L1B16_19635	COG0300	oxidoreductase activity
L1B16_19640	COG0604	alcohol dehydrogenase
L1B16_19650	COG0477	Major facilitator Superfamily
L1B16_19660	COG5002	protein histidine kinase activity
L1B16_19660	COG2205	protein histidine kinase activity
L1B16_19660	COG0784	Response regulator, receiver
L1B16_19665	COG2733	membrane
L1B16_19675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L1B16_19680	COG2223	nitrite transmembrane transporter activity
L1B16_19690	COG0243	molybdopterin cofactor binding
L1B16_19700	COG0477	Major facilitator Superfamily
L1B16_19705	COG2703	oxygen carrier activity
L1B16_19715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1B16_19720	COG0174	glutamine synthetase
L1B16_19725	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L1B16_19730	COG0174	glutamine synthetase
L1B16_19740	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L1B16_19760	COG3842	ATPase activity
L1B16_19765	COG1176	ABC-type spermidine putrescine transport system, permease component I
L1B16_19770	COG1177	transmembrane transport
L1B16_19780	COG1012	belongs to the aldehyde dehydrogenase family
L1B16_19795	COG4535	Mg2 and Co2 transporter CorC
L1B16_19815	COG1702	phosphate starvation-inducible protein PhoH
L1B16_19835	COG0741	lytic transglycosylase activity
L1B16_19840	COG0723	plastoquinol--plastocyanin reductase activity
L1B16_19845	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L1B16_19850	COG2857	Cytochrome c1
L1B16_19855	COG0625	glutathione transferase activity
L1B16_19860	COG2969	positive regulation of protein catabolic process
L1B16_19870	COG1201	RNA secondary structure unwinding
L1B16_19875	COG2094	Belongs to the DNA glycosylase MPG family
L1B16_19880	COG0840	transmembrane signaling receptor activity
L1B16_19885	COG0835	chemotaxis
L1B16_19890	COG2199	diguanylate cyclase activity
L1B16_19915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L1B16_19930	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L1B16_19935	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L1B16_19935	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L1B16_19945	COG0860	N-Acetylmuramoyl-L-alanine amidase
L1B16_19950	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L1B16_19970	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_19975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L1B16_19995	COG4681	YaeQ
L1B16_20010	COG0625	glutathione transferase activity
L1B16_20020	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L1B16_20025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L1B16_20030	COG0513	Belongs to the DEAD box helicase family
L1B16_20035	COG0488	(ABC) transporter
L1B16_20050	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L1B16_20055	COG0483	inositol monophosphate 1-phosphatase activity
L1B16_20070	COG5001	Diguanylate cyclase
L1B16_20070	COG3300	MHYT domain
L1B16_20080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L1B16_20090	COG0402	S-adenosylhomocysteine deaminase activity
L1B16_20095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L1B16_20145	COG4302	ethanolamine ammonia-lyase activity
L1B16_20150	COG4303	Ethanolamine ammonia lyase large subunit
L1B16_20165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L1B16_20185	COG2166	iron-sulfur cluster assembly
L1B16_20190	COG0215	cysteine-tRNA ligase activity
L1B16_20200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L1B16_20205	COG0137	argininosuccinate synthase activity
L1B16_20210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1B16_20215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L1B16_20230	COG0165	Argininosuccinate lyase
L1B16_20275	COG1294	oxidase, subunit
L1B16_20285	COG4988	ABC transporter
L1B16_20290	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L1B16_20300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1B16_20325	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
L1B16_20345	COG4133	protoheme IX ABC transporter activity
L1B16_20350	COG0436	Aminotransferase
L1B16_20370	COG1187	pseudouridine synthase activity
L1B16_20375	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L1B16_20380	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L1B16_20385	COG2350	Protein conserved in bacteria
L1B16_20395	COG1609	Transcriptional regulator
L1B16_20415	COG1175	transmembrane transport
L1B16_20420	COG0395	ABC-type sugar transport system, permease component
L1B16_20445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L1B16_20450	COG2957	Belongs to the agmatine deiminase family
L1B16_20465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L1B16_20470	COG0539	negative regulation of cytoplasmic translation
L1B16_20485	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
L1B16_20500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L1B16_20515	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L1B16_20530	COG0582	viral genome integration into host DNA
L1B16_20580	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_20605	COG1914	H( )-stimulated, divalent metal cation uptake system
L1B16_20620	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L1B16_20625	COG0668	transmembrane transport
L1B16_20650	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_20655	COG1183	phosphatidylcholine synthase activity
L1B16_20665	COG3243	poly(R)-hydroxyalkanoic acid synthase
L1B16_20680	COG0723	plastoquinol--plastocyanin reductase activity
L1B16_20680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1B16_20690	COG2183	response to ionizing radiation
L1B16_20695	COG0784	Response regulator, receiver
L1B16_20695	COG2205	protein histidine kinase activity
L1B16_20695	COG5002	protein histidine kinase activity
L1B16_20860	COG0800	Aldolase
L1B16_20865	COG0129	dihydroxy-acid dehydratase activity
L1B16_20875	COG0837	glucose binding
L1B16_20880	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L1B16_20900	COG2009	succinate dehydrogenase
L1B16_20905	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L1B16_20920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L1B16_20925	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L1B16_20935	COG4591	ABC-type transport system involved in lipoprotein release permease component
L1B16_20940	COG1136	(ABC) transporter
L1B16_20955	COG0811	peptide transport
L1B16_20960	COG0848	biopolymer transport protein
L1B16_20965	COG1132	(ABC) transporter
L1B16_20970	COG1663	tetraacyldisaccharide 4'-kinase activity
L1B16_20975	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L1B16_20980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L1B16_20990	COG0322	excinuclease ABC activity
L1B16_20995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L1B16_21020	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L1B16_21040	COG1054	Belongs to the UPF0176 family
L1B16_21050	COG1530	ribonuclease E activity
L1B16_21060	COG0428	transporter
L1B16_21315	COG1028	Short-chain dehydrogenase reductase Sdr
L1B16_21330	COG2197	response regulator
L1B16_21345	COG3781	membrane
L1B16_21375	COG0840	transmembrane signaling receptor activity
L1B16_21435	COG4191	Histidine kinase
L1B16_21435	COG0784	Response regulator, receiver
L1B16_21505	COG5001	Diguanylate cyclase
L1B16_21525	COG0579	oxidoreductase
L1B16_21540	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
L1B16_21565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L1B16_21565	COG1648	precorrin-2 dehydrogenase activity
L1B16_21575	COG0746	molybdenum cofactor guanylyltransferase activity
L1B16_21580	COG0303	'Molybdopterin
L1B16_21590	COG0708	Exodeoxyribonuclease III
L1B16_21615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L1B16_21620	COG0303	'Molybdopterin
L1B16_21625	COG1160	GTP binding
L1B16_21630	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L1B16_21640	COG1426	Protein conserved in bacteria
L1B16_21650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L1B16_21665	COG1024	Enoyl-CoA hydratase
L1B16_21665	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1B16_21670	COG0183	Belongs to the thiolase family
L1B16_21675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L1B16_21680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L1B16_21700	COG1674	ftsk spoiiie
L1B16_21705	COG0492	ferredoxin-NADP+ reductase activity
L1B16_21715	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L1B16_21725	COG0542	response to heat
L1B16_21740	COG0482	sulfurtransferase activity
L1B16_21775	COG4191	Histidine kinase
L1B16_21795	COG0784	Response regulator, receiver
L1B16_21795	COG0835	chemotaxis
L1B16_21800	COG1815	bacterial-type flagellum-dependent cell motility
L1B16_21805	COG1558	bacterial-type flagellum-dependent cell motility
L1B16_21810	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
L1B16_21820	COG4787	bacterial-type flagellum-dependent cell motility
L1B16_21830	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
L1B16_21835	COG1706	bacterial-type flagellum-dependent cell motility
L1B16_21840	COG3951	Flagellar rod assembly protein muramidase FlgJ
L1B16_21840	COG1705	Flagellar rod assembly protein muramidase FlgJ
L1B16_21850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L1B16_21855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L1B16_21860	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
L1B16_21890	COG2201	protein-glutamate methylesterase activity
L1B16_21930	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L1B16_22010	COG4644	lycopene metabolic process
L1B16_22015	COG2951	lytic endotransglycosylase activity
L1B16_22070	COG1192	Involved in chromosome partitioning
L1B16_22100	COG1674	ftsk spoiiie
L1B16_22175	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L1B16_22255	COG4644	lycopene metabolic process
L1B16_22260	COG2951	lytic endotransglycosylase activity