locus-tag	class	description
XACM_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XACM_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XACM_0005	COG0187	DNA topoisomerase II activity
XACM_0007	COG0501	Belongs to the peptidase M48B family
XACM_0014	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XACM_0016	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XACM_0024	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XACM_0025	COG0793	Belongs to the peptidase S41A family
XACM_0026	COG4942	peptidase
XACM_0028	COG2234	aminopeptidase activity
XACM_0030	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XACM_0031	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XACM_0032	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XACM_0033	COG1064	alcohol dehydrogenase
XACM_0034	COG0493	'glutamate synthase
XACM_0035	COG0070	glutamate synthase
XACM_0035	COG0067	glutamate synthase
XACM_0035	COG0069	glutamate synthase activity
XACM_0052	COG1111	helicase
XACM_0052	COG1205	dead DEAH box helicase
XACM_0053	COG1272	protein, Hemolysin III
XACM_0056	COG0300	oxidoreductase activity
XACM_0057	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_0061	COG2249	NAD(P)H dehydrogenase (quinone) activity
XACM_0063	COG2801	Transposase and inactivated derivatives
XACM_0064	COG2963	transposase activity
XACM_0066	COG2801	Transposase and inactivated derivatives
XACM_0067	COG2963	transposase activity
XACM_0072	COG3237	CsbD-like
XACM_0081	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XACM_0082	COG0477	Major facilitator Superfamily
XACM_0090	COG0714	Associated with various cellular activities
XACM_0099	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XACM_0101	COG4772	TonB-dependent receptor
XACM_0104	COG1012	belongs to the aldehyde dehydrogenase family
XACM_0109	COG1304	FMN binding
XACM_0112	COG1755	Isoprenylcysteine carboxyl methyltransferase
XACM_0113	COG4585	Histidine kinase
XACM_0114	COG2197	response regulator
XACM_0117	COG3710	Transcriptional regulator
XACM_0118	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XACM_0120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XACM_0131	COG2963	transposase activity
XACM_0132	COG2801	Transposase and inactivated derivatives
XACM_0139	COG0366	Alpha amylase catalytic
XACM_0140	COG0366	Alpha amylase catalytic
XACM_0141	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XACM_0144	COG2272	Belongs to the type-B carboxylesterase lipase family
XACM_0145	COG2755	lipolytic protein G-D-S-L family
XACM_0145	COG0657	acetylesterase activity
XACM_0147	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
XACM_0150	COG3507	Belongs to the glycosyl hydrolase 43 family
XACM_0151	COG1609	Transcriptional regulator
XACM_0153	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
XACM_0154	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_0156	COG2755	lipolytic protein G-D-S-L family
XACM_0158	COG3186	Phenylalanine-4-hydroxylase
XACM_0159	COG1522	sequence-specific DNA binding
XACM_0161	COG1752	Esterase of the alpha-beta hydrolase superfamily
XACM_0162	COG1473	amidohydrolase
XACM_0164	COG1119	ATPase activity
XACM_0167	COG1125	glycine betaine transport
XACM_0169	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XACM_0177	COG0489	protein tyrosine kinase activity
XACM_0178	COG2062	phosphohistidine phosphatase, SixA
XACM_0180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XACM_0188	COG1968	undecaprenyl-diphosphatase activity
XACM_0189	COG0174	glutamine synthetase
XACM_0190	COG0347	Belongs to the P(II) protein family
XACM_0191	COG0004	ammonium transporteR
XACM_0192	COG3852	Histidine kinase
XACM_0193	COG2204	response regulator
XACM_0194	COG2032	superoxide dismutase activity
XACM_0195	COG2032	superoxide dismutase activity
XACM_0196	COG0346	lactoylglutathione lyase activity
XACM_0198	COG0183	Belongs to the thiolase family
XACM_0205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XACM_0206	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XACM_0207	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XACM_0209	COG0028	Belongs to the TPP enzyme family
XACM_0210	COG2205	protein histidine kinase activity
XACM_0216	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XACM_0219	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XACM_0220	COG3177	Filamentation induced by cAMP protein fic
XACM_0221	COG0596	Alpha beta hydrolase
XACM_0223	COG0318	PFAM AMP-dependent synthetase and ligase
XACM_0224	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XACM_0226	COG1181	Belongs to the D-alanine--D-alanine ligase family
XACM_0228	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XACM_0230	COG0564	pseudouridine synthase activity
XACM_0234	COG1446	asparaginase
XACM_0235	COG0339	signal peptide processing
XACM_0240	COG0475	glutathione-regulated potassium exporter activity
XACM_0241	COG0583	DNA-binding transcription factor activity
XACM_0242	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XACM_0243	COG2224	Isocitrate lyase
XACM_0244	COG3706	GGDEF domain
XACM_0250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
XACM_0251	COG1960	acyl-CoA dehydrogenase activity
XACM_0262	COG0523	cobalamin synthesis protein
XACM_0264	COG0697	spore germination
XACM_0266	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XACM_0267	COG1846	Transcriptional regulator
XACM_0268	COG1764	response to oxidative stress
XACM_0272	COG2130	NADP-dependent
XACM_0275	COG1187	pseudouridine synthase activity
XACM_0277	COG1643	Atp-dependent helicase
XACM_0279	COG4807	Protein conserved in bacteria
XACM_0280	COG2351	hydroxyisourate hydrolase activity
XACM_0281	COG2072	flavoprotein involved in K transport
XACM_0285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
XACM_0287	COG0583	DNA-binding transcription factor activity
XACM_0294	COG2252	PERMEase
XACM_0299	COG0084	hydrolase, TatD family'
XACM_0302	COG0583	DNA-binding transcription factor activity
XACM_0303	COG2814	Major facilitator Superfamily
XACM_0305	COG2267	carboxylic ester hydrolase activity
XACM_0306	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XACM_0307	COG1902	pentaerythritol trinitrate reductase activity
XACM_0311	COG0745	RESPONSE REGULATOR receiver
XACM_0312	COG2205	protein histidine kinase activity
XACM_0313	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_0315	COG1538	Outer membrane efflux protein
XACM_0318	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XACM_0319	COG0583	DNA-binding transcription factor activity
XACM_0326	COG0702	epimerase
XACM_0327	COG1733	regulation of RNA biosynthetic process
XACM_0329	COG2801	Transposase and inactivated derivatives
XACM_0330	COG2963	transposase activity
XACM_0333	COG0129	dihydroxy-acid dehydratase activity
XACM_0336	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XACM_0346	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XACM_0347	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XACM_0352	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XACM_0353	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
XACM_0355	COG3485	protocatechuate 3,4-dioxygenase
XACM_0356	COG3485	protocatechuate 3,4-dioxygenase
XACM_0358	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XACM_0359	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XACM_0361	COG1414	Transcriptional regulator
XACM_0365	COG0445	tRNA wobble uridine modification
XACM_0368	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
XACM_0373	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_0374	COG2267	carboxylic ester hydrolase activity
XACM_0376	COG0156	8-amino-7-oxononanoate synthase activity
XACM_0377	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XACM_0378	COG1040	competence protein
XACM_0379	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XACM_0396	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XACM_0411	COG3264	Mechanosensitive ion channel
XACM_0411	COG1511	domain protein
XACM_0412	COG1368	sulfuric ester hydrolase activity
XACM_0414	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XACM_0415	COG2354	Protein conserved in bacteria
XACM_0416	COG0745	RESPONSE REGULATOR receiver
XACM_0416	COG3706	GGDEF domain
XACM_0417	COG0297	glycogen (starch) synthase activity
XACM_0418	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XACM_0419	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
XACM_0424	COG0702	epimerase
XACM_0425	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_0431	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XACM_0432	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_0434	COG0513	Belongs to the DEAD box helicase family
XACM_0436	COG0508	dehydrogenase complex catalyzes the overall conversion of
XACM_0439	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
XACM_0441	COG3483	tryptophan 2,3-dioxygenase activity
XACM_0442	COG3104	oligopeptide transport
XACM_0446	COG2852	Protein conserved in bacteria
XACM_0447	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
XACM_0450	COG1320	monovalent cation:proton antiporter activity
XACM_0451	COG2212	antiporter activity
XACM_0453	COG0651	ATP synthesis coupled electron transport
XACM_0454	COG1006	Multisubunit Na H antiporter MnhC subunit
XACM_0455	COG2111	Na H antiporter
XACM_0455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XACM_0459	COG3179	chitinase
XACM_0463	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XACM_0464	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XACM_0465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
XACM_0466	COG0456	acetyltransferase
XACM_0467	COG1597	lipid kinase activity
XACM_0473	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XACM_0474	COG0134	indole-3-glycerol-phosphate synthase activity
XACM_0476	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XACM_0477	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XACM_0479	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XACM_0480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XACM_0481	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XACM_0484	COG1051	belongs to the nudix hydrolase family
XACM_0492	COG0316	Belongs to the HesB IscA family
XACM_0496	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XACM_0501	COG2814	Major facilitator Superfamily
XACM_0502	COG1289	transmembrane transporter activity
XACM_0503	COG0151	Belongs to the GarS family
XACM_0505	COG0138	bifunctional purine biosynthesis protein purh
XACM_0506	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XACM_0507	COG2267	carboxylic ester hydrolase activity
XACM_0508	COG0671	phosphoesterase, PA-phosphatase related
XACM_0508	COG2453	phosphatase
XACM_0513	COG4589	Belongs to the CDS family
XACM_0514	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XACM_0519	COG2264	protein methyltransferase activity
XACM_0523	COG0439	Biotin carboxylase
XACM_0525	COG0511	ligase activity, forming carbon-carbon bonds
XACM_0526	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XACM_0528	COG1324	tolerance protein
XACM_0529	COG2356	endonuclease I
XACM_0530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
XACM_0531	COG0459	protein refolding
XACM_0534	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XACM_0537	COG3386	PFAM SMP-30 Gluconolaconase
XACM_0539	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XACM_0540	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XACM_0545	COG0778	Nitroreductase
XACM_0546	COG2353	YceI-like domain
XACM_0552	COG3052	prosthetic group binding
XACM_0556	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
XACM_0557	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XACM_0559	COG1802	Transcriptional regulator
XACM_0560	COG0546	phosphoglycolate phosphatase activity
XACM_0574	COG2963	transposase activity
XACM_0575	COG2801	Transposase and inactivated derivatives
XACM_0584	COG0435	Glutathione S-transferase
XACM_0589	COG2409	Drug exporters of the RND superfamily
XACM_0593	COG3706	GGDEF domain
XACM_0594	COG1959	2 iron, 2 sulfur cluster binding
XACM_0599	COG0697	spore germination
XACM_0603	COG1113	amino acid transport
XACM_0605	COG0598	Magnesium transport protein CorA
XACM_0607	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
XACM_0613	COG5001	Diguanylate cyclase
XACM_0614	COG0840	transmembrane signaling receptor activity
XACM_0615	COG5297	Belongs to the glycosyl hydrolase family 6
XACM_0615	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XACM_0616	COG0659	secondary active sulfate transmembrane transporter activity
XACM_0617	COG3706	GGDEF domain
XACM_0620	COG2943	transferase activity, transferring hexosyl groups
XACM_0622	COG3275	phosphorelay sensor kinase activity
XACM_0624	COG0181	hydroxymethylbilane synthase activity
XACM_0630	COG1505	serine-type exopeptidase activity
XACM_0633	COG2832	Protein of unknown function (DUF454)
XACM_0635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XACM_0638	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XACM_0639	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XACM_0640	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XACM_0646	COG5001	Diguanylate cyclase
XACM_0646	COG3300	MHYT domain
XACM_0647	COG0308	aminopeptidase N
XACM_0654	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
XACM_0656	COG3284	Transcriptional regulator
XACM_0658	COG1077	Cell shape determining protein MreB Mrl
XACM_0659	COG1792	Involved in formation and maintenance of cell shape
XACM_0662	COG0772	Belongs to the SEDS family
XACM_0666	COG2951	lytic endotransglycosylase activity
XACM_0667	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XACM_0668	COG1686	Belongs to the peptidase S11 family
XACM_0671	COG2921	Belongs to the UPF0250 family
XACM_0672	COG0321	lipoyl(octanoyl) transferase activity
XACM_0673	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XACM_0676	COG0583	DNA-binding transcription factor activity
XACM_0678	COG1051	belongs to the nudix hydrolase family
XACM_0678	COG1056	cytidyltransferase-related domain
XACM_0685	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
XACM_0686	COG0673	inositol 2-dehydrogenase activity
XACM_0687	COG2823	Periplasmic or secreted lipoprotein
XACM_0688	COG4251	negative regulation of phosphorylation
XACM_0689	COG0784	Response regulator, receiver
XACM_0690	COG4191	Histidine kinase
XACM_0691	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XACM_0702	COG1459	type II secretion system
XACM_0706	COG4795	General secretion pathway protein
XACM_0713	COG1609	Transcriptional regulator
XACM_0714	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XACM_0715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XACM_0717	COG0617	tRNA 3'-terminal CCA addition
XACM_0718	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XACM_0719	COG1012	belongs to the aldehyde dehydrogenase family
XACM_0720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XACM_0725	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XACM_0727	COG2205	protein histidine kinase activity
XACM_0728	COG0745	RESPONSE REGULATOR receiver
XACM_0733	COG3791	Glutathione-dependent formaldehyde-activating
XACM_0734	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
XACM_0736	COG0488	(ABC) transporter
XACM_0738	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XACM_0740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XACM_0742	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XACM_0742	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XACM_0746	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XACM_0747	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XACM_0748	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XACM_0752	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XACM_0753	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XACM_0755	COG2205	protein histidine kinase activity
XACM_0756	COG0745	RESPONSE REGULATOR receiver
XACM_0757	COG0277	FAD linked oxidase domain protein
XACM_0758	COG1988	membrane-bound metal-dependent
XACM_0759	COG0792	nuclease activity
XACM_0766	COG2001	Belongs to the MraZ family
XACM_0767	COG0275	rRNA processing
XACM_0768	COG3116	cell division
XACM_0771	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XACM_0772	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XACM_0773	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XACM_0775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XACM_0776	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XACM_0777	COG1181	Belongs to the D-alanine--D-alanine ligase family
XACM_0778	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XACM_0781	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XACM_0783	COG0739	heme binding
XACM_0784	COG0653	protein targeting
XACM_0785	COG0494	nUDIX hydrolase
XACM_0787	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
XACM_0789	COG0604	alcohol dehydrogenase
XACM_0789	COG3321	synthase
XACM_0789	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_0793	COG0366	Alpha amylase catalytic
XACM_0799	COG2226	methyltransferase
XACM_0800	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XACM_0802	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XACM_0809	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XACM_0811	COG4106	trans-aconitate 2-methyltransferase activity
XACM_0812	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XACM_0815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XACM_0816	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XACM_0818	COG0667	Aldo Keto reductase
XACM_0821	COG4771	TonB-dependent receptor
XACM_0825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
XACM_0826	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
XACM_0828	COG2175	clavaminate synthase activity
XACM_0830	COG4181	ATPase activity
XACM_0833	COG0642	Histidine kinase
XACM_0835	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XACM_0839	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XACM_0840	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XACM_0843	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XACM_0844	COG2967	ApaG domain
XACM_0845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XACM_0846	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XACM_0847	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XACM_0848	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XACM_0849	COG0123	including yeast histone deacetylase and acetoin utilization protein
XACM_0850	COG2096	Adenosyltransferase
XACM_0852	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XACM_0853	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XACM_0860	COG3384	dioxygenase
XACM_0861	COG0583	DNA-binding transcription factor activity
XACM_0862	COG0318	PFAM AMP-dependent synthetase and ligase
XACM_0864	COG1024	Enoyl-CoA hydratase
XACM_0868	COG3386	PFAM SMP-30 Gluconolaconase
XACM_0870	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XACM_0874	COG0697	spore germination
XACM_0875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XACM_0878	COG3706	GGDEF domain
XACM_0878	COG0745	RESPONSE REGULATOR receiver
XACM_0880	COG2197	response regulator
XACM_0882	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XACM_0884	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XACM_0885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XACM_0886	COG0583	DNA-binding transcription factor activity
XACM_0887	COG3634	alkyl hydroperoxide reductase activity
XACM_0889	COG2890	protein-(glutamine-N5) methyltransferase activity
XACM_0893	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XACM_0893	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XACM_0897	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XACM_0901	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XACM_0902	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XACM_0906	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XACM_0907	COG1404	Belongs to the peptidase S8 family
XACM_0908	COG1404	Belongs to the peptidase S8 family
XACM_0909	COG1404	Belongs to the peptidase S8 family
XACM_0910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XACM_0916	COG1295	ribonuclease BN
XACM_0917	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XACM_0918	COG1254	Belongs to the acylphosphatase family
XACM_0921	COG0521	Mo-molybdopterin cofactor biosynthetic process
XACM_0923	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XACM_0924	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XACM_0926	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XACM_0927	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XACM_0929	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XACM_0930	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XACM_0931	COG0193	aminoacyl-tRNA hydrolase activity
XACM_0932	COG0012	GTP binding
XACM_0936	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XACM_0938	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XACM_0939	COG0250	Participates in transcription elongation, termination and antitermination
XACM_0940	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XACM_0941	COG0081	regulation of translation
XACM_0942	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XACM_0943	COG0222	ribosome binding
XACM_0944	COG0085	RNA polymerase activity
XACM_0945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XACM_0946	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XACM_0947	COG0049	tRNA binding
XACM_0948	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XACM_0949	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XACM_0952	COG0051	transcription antitermination factor activity, RNA binding
XACM_0953	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XACM_0954	COG0088	Forms part of the polypeptide exit tunnel
XACM_0956	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XACM_0957	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XACM_0958	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XACM_0959	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XACM_0960	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XACM_0961	COG0255	Belongs to the universal ribosomal protein uL29 family
XACM_0962	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XACM_0963	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XACM_0964	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XACM_0965	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XACM_0966	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XACM_0967	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XACM_0968	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XACM_0969	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XACM_0970	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XACM_0971	COG1841	ribosomal large subunit assembly
XACM_0972	COG0200	Binds to the 23S rRNA
XACM_0973	COG0201	protein transport
XACM_0974	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XACM_0975	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XACM_0976	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XACM_0977	COG0202	RNA polymerase activity
XACM_0978	COG0203	ribosomal protein L17
XACM_0979	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XACM_0982	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
XACM_0984	COG0154	amidase activity
XACM_0987	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XACM_0988	COG0039	L-malate dehydrogenase activity
XACM_0989	COG0625	glutathione transferase activity
XACM_0992	COG1902	pentaerythritol trinitrate reductase activity
XACM_0992	COG0446	pyridine nucleotide-disulphide oxidoreductase
XACM_0994	COG0604	alcohol dehydrogenase
XACM_0995	COG2885	chlorophyll binding
XACM_0999	COG0156	8-amino-7-oxononanoate synthase activity
XACM_1000	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XACM_1001	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XACM_1002	COG4208	sulfate ABC transporter
XACM_1003	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XACM_1005	COG1063	alcohol dehydrogenase
XACM_1009	COG0406	alpha-ribazole phosphatase activity
XACM_1010	COG0285	dihydrofolate synthase activity
XACM_1014	COG2833	Protein of unknown function (DUF455)
XACM_1015	COG3291	Pkd domain containing protein
XACM_1017	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XACM_1018	COG0671	phosphoesterase, PA-phosphatase related
XACM_1019	COG0438	transferase activity, transferring glycosyl groups
XACM_1021	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XACM_1024	COG4783	chaperone-mediated protein folding
XACM_1027	COG0473	3-isopropylmalate dehydrogenase activity
XACM_1033	COG3852	Histidine kinase
XACM_1035	COG0544	peptidyl-prolyl cis-trans isomerase activity
XACM_1036	COG0740	serine-type endopeptidase activity
XACM_1037	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XACM_1043	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XACM_1047	COG0328	RNA-DNA hybrid ribonuclease activity
XACM_1048	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XACM_1049	COG0631	protein serine/threonine phosphatase activity
XACM_1052	COG0859	PFAM glycosyl transferase family 9
XACM_1053	COG3642	lipopolysaccharide core region biosynthetic process
XACM_1054	COG1234	tRNA 3'-trailer cleavage
XACM_1055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XACM_1057	COG0315	cyclic pyranopterin monophosphate synthase activity
XACM_1058	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XACM_1059	COG0314	molybdopterin synthase activity
XACM_1069	COG2801	Transposase and inactivated derivatives
XACM_1070	COG2963	transposase activity
XACM_1077	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XACM_1078	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XACM_1079	COG0537	adenosine 5'-monophosphoramidase activity
XACM_1083	COG0714	Associated with various cellular activities
XACM_1086	COG0424	maF-like protein
XACM_1087	COG1399	metal-binding, possibly nucleic acid-binding protein
XACM_1088	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XACM_1089	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XACM_1093	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XACM_1095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XACM_1096	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XACM_1102	COG3829	transcription factor binding
XACM_1107	COG2828	Protein conserved in bacteria
XACM_1111	COG2373	Large extracellular alpha-helical protein
XACM_1114	COG4953	penicillin-binding protein 1C
XACM_1116	COG0678	peroxiredoxin activity
XACM_1120	COG0330	HflC and HflK could
XACM_1121	COG0330	HflC and HflK could
XACM_1124	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XACM_1125	COG0308	aminopeptidase N
XACM_1127	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_1128	COG1309	transcriptional regulator
XACM_1144	COG0406	alpha-ribazole phosphatase activity
XACM_1144	COG0328	RNA-DNA hybrid ribonuclease activity
XACM_1145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XACM_1147	COG3387	PFAM Glycoside hydrolase 15-related
XACM_1148	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_1149	COG3537	Alpha-1,2-mannosidase
XACM_1150	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_1152	COG0492	ferredoxin-NADP+ reductase activity
XACM_1157	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XACM_1158	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XACM_1159	COG2080	2 iron, 2 sulfur cluster binding
XACM_1166	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XACM_1169	COG0587	DNA-directed DNA polymerase activity
XACM_1172	COG1297	OPT oligopeptide transporter protein
XACM_1174	COG1506	peptidase
XACM_1174	COG0823	Involved in the tonB-independent uptake of proteins
XACM_1177	COG2207	Transcriptional regulator
XACM_1177	COG1917	Cupin 2, conserved barrel domain protein
XACM_1182	COG0753	catalase activity
XACM_1183	COG0656	L-ascorbic acid biosynthetic process
XACM_1184	COG2272	Belongs to the type-B carboxylesterase lipase family
XACM_1185	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XACM_1185	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XACM_1190	COG2814	Major facilitator Superfamily
XACM_1193	COG2194	sulfuric ester hydrolase activity
XACM_1196	COG0745	RESPONSE REGULATOR receiver
XACM_1197	COG0642	Histidine kinase
XACM_1199	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XACM_1200	COG2894	cell division
XACM_1201	COG0850	regulation of cytokinetic process
XACM_1203	COG4585	Histidine kinase
XACM_1204	COG2197	response regulator
XACM_1207	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XACM_1212	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
XACM_1214	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XACM_1217	COG1595	DNA-templated transcription, initiation
XACM_1219	COG1946	Acyl-CoA thioesterase
XACM_1220	COG1024	Enoyl-CoA hydratase
XACM_1222	COG0824	Thioesterase
XACM_1223	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XACM_1224	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XACM_1225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XACM_1226	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XACM_1227	COG0268	Binds directly to 16S ribosomal RNA
XACM_1229	COG0196	riboflavin kinase activity
XACM_1230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XACM_1231	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XACM_1232	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XACM_1235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XACM_1236	COG1845	cytochrome c oxidase, subunit III
XACM_1237	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XACM_1240	COG3152	Membrane
XACM_1243	COG2207	Transcriptional regulator
XACM_1244	COG0326	Molecular chaperone. Has ATPase activity
XACM_1246	COG1366	Belongs to the anti-sigma-factor antagonist family
XACM_1247	COG1366	Belongs to the anti-sigma-factor antagonist family
XACM_1248	COG2172	sigma factor antagonist activity
XACM_1253	COG4771	TonB-dependent receptor
XACM_1255	COG5507	3-demethylubiquinone-9 3-methyltransferase
XACM_1256	COG2205	protein histidine kinase activity
XACM_1258	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XACM_1259	COG2205	protein histidine kinase activity
XACM_1259	COG3437	response regulator, receiver
XACM_1259	COG4999	Histidine kinase
XACM_1259	COG3850	Histidine kinase
XACM_1260	COG4191	Histidine kinase
XACM_1260	COG0784	Response regulator, receiver
XACM_1265	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XACM_1266	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XACM_1268	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XACM_1269	COG0228	four-way junction DNA binding
XACM_1270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XACM_1271	COG0336	Belongs to the RNA methyltransferase TrmD family
XACM_1272	COG0335	large ribosomal subunit rRNA binding
XACM_1273	COG0534	Mate efflux family protein
XACM_1277	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XACM_1279	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XACM_1283	COG3483	tryptophan 2,3-dioxygenase activity
XACM_1288	COG0840	transmembrane signaling receptor activity
XACM_1291	COG3250	beta-galactosidase activity
XACM_1292	COG3867	Arabinogalactan endo-beta-1,4-galactanase
XACM_1296	COG1960	acyl-CoA dehydrogenase activity
XACM_1301	COG1024	Enoyl-CoA hydratase
XACM_1301	COG1250	3-hydroxyacyl-CoA dehydrogenase
XACM_1304	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XACM_1305	COG0481	GTPase activity
XACM_1308	COG0571	ribonuclease III activity
XACM_1309	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XACM_1310	COG1381	Involved in DNA repair and RecF pathway recombination
XACM_1312	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XACM_1314	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XACM_1316	COG3046	protein related to deoxyribodipyrimidine photolyase
XACM_1317	COG1472	Belongs to the glycosyl hydrolase 3 family
XACM_1319	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XACM_1320	COG1278	Cold shock
XACM_1321	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XACM_1323	COG1201	RNA secondary structure unwinding
XACM_1324	COG1793	dna ligase
XACM_1325	COG1793	dna ligase
XACM_1325	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
XACM_1328	COG3706	GGDEF domain
XACM_1328	COG0745	RESPONSE REGULATOR receiver
XACM_1332	COG0183	Belongs to the thiolase family
XACM_1336	COG1451	nucleotide metabolic process
XACM_1337	COG5487	UPF0391 membrane protein
XACM_1339	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XACM_1343	COG1047	Peptidyl-prolyl cis-trans
XACM_1345	COG2824	Alkylphosphonate utilization operon protein PhnA
XACM_1346	COG1902	pentaerythritol trinitrate reductase activity
XACM_1347	COG2814	Major facilitator Superfamily
XACM_1354	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XACM_1354	COG0392	lysyltransferase activity
XACM_1356	COG0251	oxidation-reduction process
XACM_1357	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XACM_1360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XACM_1365	COG1595	DNA-templated transcription, initiation
XACM_1368	COG2878	Part of a membrane complex involved in electron transport
XACM_1370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XACM_1370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XACM_1374	COG0346	lactoylglutathione lyase activity
XACM_1377	COG0833	amino acid
XACM_1378	COG2040	homocysteine
XACM_1380	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XACM_1386	COG1695	Transcriptional regulator
XACM_1393	COG0825	malonyl-CoA metabolic process
XACM_1397	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XACM_1398	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XACM_1399	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XACM_1400	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XACM_1402	COG0750	zinc metalloprotease
XACM_1403	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XACM_1404	COG0575	Belongs to the CDS family
XACM_1405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XACM_1406	COG0233	cytoplasmic translational termination
XACM_1407	COG0528	UMP kinase activity
XACM_1408	COG3706	GGDEF domain
XACM_1408	COG0745	RESPONSE REGULATOR receiver
XACM_1409	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XACM_1410	COG0052	Belongs to the universal ribosomal protein uS2 family
XACM_1417	COG0024	Methionine aminopeptidase
XACM_1418	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XACM_1420	COG1393	Belongs to the ArsC family
XACM_1421	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XACM_1422	COG0367	asparagine synthase
XACM_1424	COG4774	siderophore transport
XACM_1427	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XACM_1432	COG1566	PFAM secretion protein HlyD family protein
XACM_1433	COG2814	Major facilitator Superfamily
XACM_1445	COG0339	signal peptide processing
XACM_1446	COG0386	Belongs to the glutathione peroxidase family
XACM_1457	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XACM_1458	COG0084	hydrolase, TatD family'
XACM_1461	COG1960	acyl-CoA dehydrogenase activity
XACM_1464	COG0367	asparagine synthase
XACM_1466	COG0305	Participates in initiation and elongation during chromosome replication
XACM_1467	COG0415	Belongs to the DNA photolyase family
XACM_1469	COG0583	DNA-binding transcription factor activity
XACM_1475	COG3706	GGDEF domain
XACM_1477	COG3706	GGDEF domain
XACM_1483	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XACM_1486	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XACM_1488	COG0497	DNA recombination
XACM_1489	COG1420	regulation of RNA biosynthetic process
XACM_1491	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XACM_1492	COG0443	Heat shock 70 kDa protein
XACM_1493	COG0484	heat shock protein binding
XACM_1494	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XACM_1500	COG0583	DNA-binding transcription factor activity
XACM_1501	COG1132	(ABC) transporter
XACM_1508	COG2850	peptidyl-arginine hydroxylation
XACM_1512	COG1253	flavin adenine dinucleotide binding
XACM_1518	COG1131	(ABC) transporter
XACM_1519	COG1725	Transcriptional regulator
XACM_1520	COG0386	Belongs to the glutathione peroxidase family
XACM_1523	COG2900	Belongs to the SlyX family
XACM_1528	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XACM_1530	COG1410	methionine synthase
XACM_1530	COG0646	methionine synthase
XACM_1531	COG1410	methionine synthase
XACM_1531	COG0646	methionine synthase
XACM_1533	COG1960	acyl-CoA dehydrogenase activity
XACM_1536	COG0557	exoribonuclease II activity
XACM_1538	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XACM_1539	COG3706	GGDEF domain
XACM_1540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XACM_1542	COG0704	Plays a role in the regulation of phosphate uptake
XACM_1543	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XACM_1544	COG0581	inorganic phosphate transmembrane transporter activity
XACM_1545	COG0573	inorganic phosphate transmembrane transporter activity
XACM_1546	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XACM_1551	COG0659	secondary active sulfate transmembrane transporter activity
XACM_1552	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XACM_1554	COG1024	Enoyl-CoA hydratase
XACM_1556	COG0494	nUDIX hydrolase
XACM_1564	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XACM_1564	COG0116	Belongs to the methyltransferase superfamily
XACM_1565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XACM_1568	COG0667	Aldo Keto reductase
XACM_1570	COG2925	Exonuclease
XACM_1572	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XACM_1573	COG3844	kynureninase activity
XACM_1575	COG0662	Cupin 2, conserved barrel domain protein
XACM_1576	COG0288	reversible hydration of carbon dioxide
XACM_1590	COG0017	Asparaginyl-tRNA synthetase
XACM_1591	COG0316	Belongs to the HesB IscA family
XACM_1592	COG0360	Binds together with S18 to 16S ribosomal RNA
XACM_1593	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XACM_1594	COG0359	binds to the 23S rRNA
XACM_1596	COG3115	cell septum assembly
XACM_1598	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XACM_1599	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XACM_1600	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XACM_1602	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XACM_1604	COG4993	Dehydrogenase
XACM_1606	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XACM_1608	COG2986	histidine ammonia-lyase
XACM_1609	COG1228	amidohydrolase
XACM_1616	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
XACM_1617	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
XACM_1618	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XACM_1619	COG0077	Prephenate dehydratase
XACM_1619	COG1605	Chorismate mutase
XACM_1620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XACM_1623	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XACM_1624	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XACM_1625	COG0583	DNA-binding transcription factor activity
XACM_1633	COG2801	Transposase and inactivated derivatives
XACM_1634	COG2963	transposase activity
XACM_1636	COG2003	Belongs to the UPF0758 family
XACM_1643	COG2801	Transposase and inactivated derivatives
XACM_1644	COG2963	transposase activity
XACM_1651	COG0758	DNA mediated transformation
XACM_1669	COG2814	Major facilitator Superfamily
XACM_1674	COG2963	transposase activity
XACM_1675	COG2801	Transposase and inactivated derivatives
XACM_1685	COG0840	transmembrane signaling receptor activity
XACM_1689	COG0745	RESPONSE REGULATOR receiver
XACM_1690	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
XACM_1691	COG4191	Histidine kinase
XACM_1691	COG0784	Response regulator, receiver
XACM_1694	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XACM_1696	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XACM_1698	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
XACM_1701	COG1595	DNA-templated transcription, initiation
XACM_1712	COG2244	polysaccharide biosynthetic process
XACM_1713	COG1216	Glycosyl transferase, family 2
XACM_1713	COG1442	glycosyl transferase family 8
XACM_1718	COG2264	protein methyltransferase activity
XACM_1720	COG0438	transferase activity, transferring glycosyl groups
XACM_1723	COG1136	(ABC) transporter
XACM_1724	COG1132	(ABC) transporter
XACM_1725	COG2271	Major facilitator Superfamily
XACM_1726	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XACM_1729	COG1253	flavin adenine dinucleotide binding
XACM_1732	COG0306	phosphate transporter
XACM_1737	COG0504	CTP synthase activity
XACM_1740	COG0148	phosphopyruvate hydratase activity
XACM_1741	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XACM_1742	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XACM_1743	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XACM_1744	COG0585	pseudouridine synthase activity
XACM_1745	COG2840	Smr protein MutS2
XACM_1746	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XACM_1747	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XACM_1748	COG1238	metal cluster binding
XACM_1751	COG1534	Rna-binding protein
XACM_1752	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XACM_1753	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XACM_1754	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XACM_1755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XACM_1756	COG1923	regulation of RNA biosynthetic process
XACM_1757	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XACM_1758	COG1546	Belongs to the CinA family
XACM_1760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XACM_1761	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XACM_1763	COG2137	regulation of response to DNA damage stimulus
XACM_1764	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XACM_1765	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XACM_1769	COG1741	Belongs to the pirin family
XACM_1770	COG0583	DNA-binding transcription factor activity
XACM_1775	COG0351	phosphomethylpyrimidine kinase
XACM_1778	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XACM_1779	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XACM_1782	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XACM_1784	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XACM_1785	COG3734	2-keto-3-deoxy-galactonokinase
XACM_1787	COG4948	Mandelate Racemase Muconate Lactonizing
XACM_1788	COG0800	Aldolase
XACM_1796	COG1501	Belongs to the glycosyl hydrolase 31 family
XACM_1798	COG1070	Carbohydrate kinase
XACM_1799	COG2115	Belongs to the xylose isomerase family
XACM_1800	COG0477	Major facilitator Superfamily
XACM_1804	COG0860	N-Acetylmuramoyl-L-alanine amidase
XACM_1805	COG1469	GTP cyclohydrolase I activity
XACM_1809	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XACM_1810	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XACM_1811	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XACM_1812	COG0166	Belongs to the GPI family
XACM_1816	COG1472	Belongs to the glycosyl hydrolase 3 family
XACM_1818	COG5001	Diguanylate cyclase
XACM_1818	COG4251	negative regulation of phosphorylation
XACM_1818	COG3706	GGDEF domain
XACM_1818	COG2203	Gaf domain
XACM_1819	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XACM_1820	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XACM_1822	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XACM_1823	COG0671	phosphoesterase, PA-phosphatase related
XACM_1825	COG1794	racemase activity, acting on amino acids and derivatives
XACM_1827	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XACM_1828	COG0167	dihydroorotate dehydrogenase activity
XACM_1831	COG1012	belongs to the aldehyde dehydrogenase family
XACM_1837	COG3210	domain, Protein
XACM_1837	COG3210	domain, Protein
XACM_1837	COG3210	domain, Protein
XACM_1841	COG2801	Transposase and inactivated derivatives
XACM_1842	COG2963	transposase activity
XACM_1845	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
XACM_1846	COG0527	aspartate kinase activity
XACM_1846	COG0460	homoserine dehydrogenase
XACM_1849	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
XACM_1851	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XACM_1852	COG0124	histidyl-tRNA synthetase
XACM_1854	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XACM_1855	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XACM_1856	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XACM_1857	COG0131	Imidazoleglycerol-phosphate dehydratase
XACM_1857	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XACM_1858	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XACM_1859	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XACM_1860	COG0107	imidazoleglycerol-phosphate synthase activity
XACM_1861	COG0140	phosphoribosyl-ATP diphosphatase activity
XACM_1861	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XACM_1864	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XACM_1865	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XACM_1866	COG0235	Class ii aldolase
XACM_1867	COG0531	amino acid
XACM_1868	COG0531	amino acid
XACM_1870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XACM_1871	COG0277	FAD linked oxidase domain protein
XACM_1875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XACM_1885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XACM_1886	COG2258	MOSC domain
XACM_1887	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XACM_1888	COG0505	Belongs to the CarA family
XACM_1890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XACM_1891	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XACM_1893	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XACM_1895	COG3279	Response regulator of the LytR AlgR family
XACM_1896	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XACM_1897	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XACM_1900	COG2205	protein histidine kinase activity
XACM_1900	COG0784	Response regulator, receiver
XACM_1900	COG2198	Histidine kinase
XACM_1901	COG1024	Enoyl-CoA hydratase
XACM_1902	COG0318	PFAM AMP-dependent synthetase and ligase
XACM_1908	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XACM_1910	COG2201	protein-glutamate methylesterase activity
XACM_1911	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
XACM_1913	COG0840	transmembrane signaling receptor activity
XACM_1915	COG0835	chemotaxis
XACM_1918	COG0840	transmembrane signaling receptor activity
XACM_1920	COG0840	transmembrane signaling receptor activity
XACM_1921	COG0840	transmembrane signaling receptor activity
XACM_1922	COG0840	transmembrane signaling receptor activity
XACM_1923	COG0840	transmembrane signaling receptor activity
XACM_1925	COG0840	transmembrane signaling receptor activity
XACM_1926	COG0840	transmembrane signaling receptor activity
XACM_1927	COG0840	transmembrane signaling receptor activity
XACM_1929	COG0840	transmembrane signaling receptor activity
XACM_1930	COG0840	transmembrane signaling receptor activity
XACM_1932	COG0840	transmembrane signaling receptor activity
XACM_1933	COG0840	transmembrane signaling receptor activity
XACM_1935	COG0745	RESPONSE REGULATOR receiver
XACM_1937	COG0835	chemotaxis
XACM_1938	COG1192	Involved in chromosome partitioning
XACM_1939	COG1360	Flagellar Motor Protein
XACM_1940	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XACM_1942	COG3039	Transposase
XACM_1951	COG2198	Histidine kinase
XACM_1951	COG0643	Histidine kinase
XACM_1955	COG0455	bacterial-type flagellum organization
XACM_1957	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XACM_1960	COG5001	Diguanylate cyclase
XACM_1960	COG3300	MHYT domain
XACM_1962	COG5001	Diguanylate cyclase
XACM_1962	COG3300	MHYT domain
XACM_1963	COG1684	flagellar biosynthetic protein fliR
XACM_1964	COG1987	bacterial-type flagellum assembly
XACM_1967	COG3190	flagellar
XACM_1977	COG1677	Flagellar hook-basal body complex protein FliE
XACM_1979	COG0275	rRNA processing
XACM_1980	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XACM_1987	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_1988	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XACM_1991	COG2204	response regulator
XACM_1992	COG2201	protein-glutamate methylesterase activity
XACM_1998	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
XACM_1999	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XACM_2000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XACM_2002	COG1705	Flagellar rod assembly protein muramidase FlgJ
XACM_2002	COG3951	Flagellar rod assembly protein muramidase FlgJ
XACM_2003	COG1706	bacterial-type flagellum-dependent cell motility
XACM_2004	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XACM_2005	COG4786	Flagellar basal body rod
XACM_2007	COG4787	bacterial-type flagellum-dependent cell motility
XACM_2008	COG1749	Flagellar hook protein flgE
XACM_2009	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XACM_2010	COG1558	bacterial-type flagellum-dependent cell motility
XACM_2012	COG0835	chemotaxis
XACM_2012	COG0784	Response regulator, receiver
XACM_2016	COG5002	protein histidine kinase activity
XACM_2023	COG2915	High frequency lysogenization protein hflD homolog
XACM_2024	COG0482	sulfurtransferase activity
XACM_2026	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XACM_2027	COG0542	response to heat
XACM_2028	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XACM_2029	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XACM_2032	COG0492	ferredoxin-NADP+ reductase activity
XACM_2033	COG1674	ftsk spoiiie
XACM_2035	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XACM_2037	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XACM_2038	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XACM_2039	COG0183	Belongs to the thiolase family
XACM_2040	COG1250	3-hydroxyacyl-CoA dehydrogenase
XACM_2040	COG1024	Enoyl-CoA hydratase
XACM_2042	COG0105	UTP biosynthetic process
XACM_2043	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XACM_2047	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XACM_2048	COG1160	GTP binding
XACM_2049	COG0303	'Molybdopterin
XACM_2050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XACM_2059	COG0708	Exodeoxyribonuclease III
XACM_2061	COG0303	'Molybdopterin
XACM_2062	COG0746	molybdenum cofactor guanylyltransferase activity
XACM_2067	COG1648	precorrin-2 dehydrogenase activity
XACM_2067	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XACM_2069	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
XACM_2070	COG2223	nitrite transmembrane transporter activity
XACM_2071	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XACM_2073	COG0243	molybdopterin cofactor binding
XACM_2077	COG3685	Protein conserved in bacteria
XACM_2080	COG5001	Diguanylate cyclase
XACM_2082	COG4566	intracellular signal transduction
XACM_2086	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_2089	COG3275	phosphorelay sensor kinase activity
XACM_2090	COG3279	Response regulator of the LytR AlgR family
XACM_2111	COG3501	Rhs element vgr protein
XACM_2118	COG0631	protein serine/threonine phosphatase activity
XACM_2119	COG0515	serine threonine protein kinase
XACM_2122	COG0583	DNA-binding transcription factor activity
XACM_2124	COG1858	cytochrome C peroxidase
XACM_2130	COG2963	transposase activity
XACM_2131	COG2801	Transposase and inactivated derivatives
XACM_2138	COG4644	lycopene metabolic process
XACM_2139	COG2951	lytic endotransglycosylase activity
XACM_2142	COG1914	H( )-stimulated, divalent metal cation uptake system
XACM_2143	COG1321	iron dependent repressor
XACM_2144	COG0590	tRNA wobble adenosine to inosine editing
XACM_2145	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XACM_2146	COG0668	transmembrane transport
XACM_2148	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XACM_2151	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_2152	COG1183	phosphatidylcholine synthase activity
XACM_2154	COG3243	poly(R)-hydroxyalkanoic acid synthase
XACM_2157	COG0723	plastoquinol--plastocyanin reductase activity
XACM_2157	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XACM_2159	COG2183	response to ionizing radiation
XACM_2160	COG0784	Response regulator, receiver
XACM_2160	COG2205	protein histidine kinase activity
XACM_2174	COG0800	Aldolase
XACM_2175	COG0129	dihydroxy-acid dehydratase activity
XACM_2176	COG0363	glucosamine-6-phosphate deaminase activity
XACM_2177	COG0837	glucose binding
XACM_2178	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XACM_2181	COG0354	folic acid binding
XACM_2183	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XACM_2186	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XACM_2187	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XACM_2189	COG4591	ABC-type transport system involved in lipoprotein release permease component
XACM_2190	COG1136	(ABC) transporter
XACM_2193	COG0811	peptide transport
XACM_2195	COG1132	(ABC) transporter
XACM_2196	COG1663	tetraacyldisaccharide 4'-kinase activity
XACM_2197	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XACM_2198	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XACM_2200	COG0322	excinuclease ABC activity
XACM_2201	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XACM_2206	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XACM_2212	COG1530	ribonuclease E activity
XACM_2215	COG3064	Membrane
XACM_2216	COG0428	transporter
XACM_2218	COG2154	pterin-4-alpha-carbinolamine dehydratase
XACM_2219	COG0316	Belongs to the HesB IscA family
XACM_2219	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XACM_2222	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_2223	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XACM_2224	COG1309	transcriptional regulator
XACM_2226	COG0596	Alpha beta hydrolase
XACM_2232	COG0363	glucosamine-6-phosphate deaminase activity
XACM_2239	COG2197	response regulator
XACM_2240	COG4585	Histidine kinase
XACM_2242	COG2951	lytic endotransglycosylase activity
XACM_2243	COG4644	lycopene metabolic process
XACM_2248	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XACM_2251	COG2814	Major facilitator Superfamily
XACM_2254	COG1335	isochorismatase
XACM_2255	COG4585	Histidine kinase
XACM_2257	COG2197	response regulator
XACM_2260	COG0583	DNA-binding transcription factor activity
XACM_2264	COG0633	Ferredoxin
XACM_2266	COG0583	DNA-binding transcription factor activity
XACM_2267	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XACM_2268	COG3002	Belongs to the UPF0753 family
XACM_2269	COG0667	Aldo Keto reductase
XACM_2270	COG0583	DNA-binding transcription factor activity
XACM_2272	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_2273	COG2818	Glycosylase
XACM_2294	COG0582	viral genome integration into host DNA
XACM_2295	COG0519	Catalyzes the synthesis of GMP from XMP
XACM_2295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XACM_2297	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XACM_2299	COG0475	glutathione-regulated potassium exporter activity
XACM_2299	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XACM_2300	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XACM_2302	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XACM_2303	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XACM_2305	COG0776	regulation of translation
XACM_2306	COG0539	negative regulation of cytoplasmic translation
XACM_2307	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XACM_2308	COG0257	Belongs to the bacterial ribosomal protein bL36 family
XACM_2310	COG2957	Belongs to the agmatine deiminase family
XACM_2311	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XACM_2316	COG0395	ABC-type sugar transport system, permease component
XACM_2317	COG1175	transmembrane transport
XACM_2323	COG2350	Protein conserved in bacteria
XACM_2324	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XACM_2325	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XACM_2326	COG1187	pseudouridine synthase activity
XACM_2330	COG0436	Aminotransferase
XACM_2331	COG4133	protoheme IX ABC transporter activity
XACM_2335	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XACM_2336	COG1138	Cytochrome C-type biogenesis protein
XACM_2340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XACM_2341	COG1278	Cold shock
XACM_2342	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XACM_2343	COG4988	ABC transporter
XACM_2345	COG1294	oxidase, subunit
XACM_2351	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XACM_2352	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XACM_2354	COG0165	Argininosuccinate lyase
XACM_2355	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XACM_2357	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XACM_2360	COG0137	argininosuccinate synthase activity
XACM_2361	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XACM_2363	COG0215	cysteine-tRNA ligase activity
XACM_2364	COG2166	iron-sulfur cluster assembly
XACM_2366	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XACM_2367	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XACM_2368	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XACM_2374	COG4302	ethanolamine ammonia-lyase activity
XACM_2381	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XACM_2382	COG0402	S-adenosylhomocysteine deaminase activity
XACM_2384	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XACM_2385	COG1509	lysine 2,3-aminomutase activity
XACM_2386	COG3300	MHYT domain
XACM_2386	COG5001	Diguanylate cyclase
XACM_2389	COG0483	inositol monophosphate 1-phosphatase activity
XACM_2394	COG0513	Belongs to the DEAD box helicase family
XACM_2395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XACM_2396	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XACM_2398	COG0625	glutathione transferase activity
XACM_2401	COG4681	YaeQ
XACM_2402	COG2081	HI0933 family
XACM_2404	COG0501	Belongs to the peptidase M48B family
XACM_2405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XACM_2406	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_2410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XACM_2411	COG0860	N-Acetylmuramoyl-L-alanine amidase
XACM_2412	COG0802	atpase or kinase
XACM_2413	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XACM_2413	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XACM_2414	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XACM_2415	COG1570	exodeoxyribonuclease VII activity
XACM_2418	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XACM_2426	COG0835	chemotaxis
XACM_2427	COG0840	transmembrane signaling receptor activity
XACM_2428	COG2094	Belongs to the DNA glycosylase MPG family
XACM_2429	COG1201	RNA secondary structure unwinding
XACM_2432	COG2969	positive regulation of protein catabolic process
XACM_2433	COG0625	glutathione transferase activity
XACM_2434	COG2857	Cytochrome c1
XACM_2435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XACM_2436	COG0723	plastoquinol--plastocyanin reductase activity
XACM_2437	COG0741	lytic transglycosylase activity
XACM_2440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XACM_2441	COG1702	phosphate starvation-inducible protein PhoH
XACM_2443	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XACM_2445	COG4535	Mg2 and Co2 transporter CorC
XACM_2448	COG1012	belongs to the aldehyde dehydrogenase family
XACM_2449	COG1177	transmembrane transport
XACM_2450	COG1176	ABC-type spermidine putrescine transport system, permease component I
XACM_2451	COG3842	ATPase activity
XACM_2455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XACM_2458	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
XACM_2459	COG0174	glutamine synthetase
XACM_2460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XACM_2461	COG0745	RESPONSE REGULATOR receiver
XACM_2461	COG3706	GGDEF domain
XACM_2462	COG2703	oxygen carrier activity
XACM_2463	COG0477	Major facilitator Superfamily
XACM_2465	COG0243	molybdopterin cofactor binding
XACM_2466	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XACM_2470	COG2733	membrane
XACM_2471	COG2205	protein histidine kinase activity
XACM_2471	COG0784	Response regulator, receiver
XACM_2471	COG5002	protein histidine kinase activity
XACM_2473	COG0477	Major facilitator Superfamily
XACM_2474	COG2902	Dehydrogenase
XACM_2476	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_2477	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XACM_2478	COG1609	Transcriptional regulator
XACM_2479	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XACM_2479	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
XACM_2480	COG1105	Belongs to the carbohydrate kinase PfkB family
XACM_2481	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XACM_2481	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
XACM_2487	COG2801	Transposase and inactivated derivatives
XACM_2488	COG2963	transposase activity
XACM_2490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XACM_2492	COG1862	Preprotein translocase
XACM_2493	COG0343	queuine tRNA-ribosyltransferase activity
XACM_2494	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XACM_2501	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XACM_2502	COG3291	Pkd domain containing protein
XACM_2503	COG0405	Gamma-glutamyltransferase
XACM_2504	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XACM_2506	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XACM_2507	COG0742	ribosomal rna small subunit methyltransferase
XACM_2508	COG0326	Molecular chaperone. Has ATPase activity
XACM_2522	COG0531	amino acid
XACM_2525	COG0006	proline dipeptidase activity
XACM_2527	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XACM_2530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XACM_2531	COG3938	Belongs to the proline racemase family
XACM_2533	COG0552	protein localization to endoplasmic reticulum
XACM_2534	COG1194	a g-specific adenine glycosylase
XACM_2535	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XACM_2536	COG0784	Response regulator, receiver
XACM_2536	COG4191	Histidine kinase
XACM_2540	COG0322	excinuclease ABC activity
XACM_2543	COG3040	lipid binding
XACM_2545	COG1960	acyl-CoA dehydrogenase activity
XACM_2547	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XACM_2551	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XACM_2552	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XACM_2553	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XACM_2560	COG0438	transferase activity, transferring glycosyl groups
XACM_2561	COG0438	transferase activity, transferring glycosyl groups
XACM_2570	COG0776	regulation of translation
XACM_2571	COG0072	phenylalanine-tRNA ligase activity
XACM_2571	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XACM_2572	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XACM_2573	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XACM_2574	COG0291	Belongs to the bacterial ribosomal protein bL35 family
XACM_2575	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XACM_2576	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XACM_2581	COG1082	Xylose isomerase domain protein TIM barrel
XACM_2583	COG0366	Alpha amylase catalytic
XACM_2596	COG3505	Type IV secretory pathway VirD4
XACM_2600	COG0556	nucleotide-excision repair
XACM_2609	COG3275	phosphorelay sensor kinase activity
XACM_2610	COG1611	Belongs to the LOG family
XACM_2613	COG2095	MarC family integral membrane protein
XACM_2615	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XACM_2616	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XACM_2622	COG1185	polyribonucleotide nucleotidyltransferase activity
XACM_2623	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XACM_2624	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XACM_2625	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XACM_2626	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XACM_2627	COG0195	Participates in both transcription termination and antitermination
XACM_2628	COG0779	Required for maturation of 30S ribosomal subunits
XACM_2630	COG1007	ATP synthesis coupled electron transport
XACM_2633	COG0713	ATP synthesis coupled electron transport
XACM_2635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XACM_2636	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XACM_2637	COG1034	ATP synthesis coupled electron transport
XACM_2638	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XACM_2639	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XACM_2640	COG0649	NAD binding
XACM_2641	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XACM_2642	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XACM_2643	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XACM_2646	COG0149	triose-phosphate isomerase activity
XACM_2647	COG4221	oxidoreductase activity
XACM_2654	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XACM_2655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XACM_2656	COG0159	tryptophan synthase activity
XACM_2658	COG0133	tryptophan synthase activity
XACM_2660	COG0135	phosphoribosylanthranilate isomerase activity
XACM_2661	COG0101	tRNA pseudouridine synthase activity
XACM_2664	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XACM_2665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XACM_2666	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XACM_2667	COG2890	protein-(glutamine-N5) methyltransferase activity
XACM_2669	COG0688	phosphatidylethanolamine metabolic process
XACM_2671	COG0433	COG0433 Predicted ATPase
XACM_2672	COG0494	nUDIX hydrolase
XACM_2675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XACM_2676	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XACM_2681	COG0717	Belongs to the dCTP deaminase family
XACM_2682	COG0489	protein tyrosine kinase activity
XACM_2686	COG3590	peptidase
XACM_2687	COG3590	peptidase
XACM_2692	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XACM_2693	COG2311	Membrane
XACM_2694	COG1047	Peptidyl-prolyl cis-trans
XACM_2695	COG0791	NLP P60 protein
XACM_2696	COG0791	NLP P60 protein
XACM_2699	COG1301	dicarboxylic acid transport
XACM_2700	COG1785	Belongs to the alkaline phosphatase family
XACM_2701	COG0037	tRNA processing
XACM_2702	COG1722	exodeoxyribonuclease VII activity
XACM_2703	COG0142	geranyltranstransferase activity
XACM_2704	COG4104	PAAR repeat-containing protein
XACM_2706	COG0312	modulator of DNA gyrase
XACM_2707	COG3028	Belongs to the UPF0307 family
XACM_2708	COG0312	modulator of DNA gyrase
XACM_2710	COG3164	Protein of unknown function
XACM_2711	COG1530	ribonuclease E activity
XACM_2712	COG0424	maF-like protein
XACM_2713	COG2968	Membrane
XACM_2716	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XACM_2719	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XACM_2722	COG0495	leucyl-tRNA aminoacylation
XACM_2724	COG3118	belongs to the thioredoxin family
XACM_2729	COG2155	Conserved Protein
XACM_2730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XACM_2740	COG1132	(ABC) transporter
XACM_2746	COG1538	Outer membrane efflux protein
XACM_2747	COG0745	RESPONSE REGULATOR receiver
XACM_2748	COG5002	protein histidine kinase activity
XACM_2748	COG5000	phosphorelay sensor kinase activity
XACM_2749	COG0475	glutathione-regulated potassium exporter activity
XACM_2750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
XACM_2751	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XACM_2754	COG3706	GGDEF domain
XACM_2755	COG1187	pseudouridine synthase activity
XACM_2756	COG5002	protein histidine kinase activity
XACM_2756	COG5001	Diguanylate cyclase
XACM_2779	COG0667	Aldo Keto reductase
XACM_2780	COG2814	Major facilitator Superfamily
XACM_2781	COG0583	DNA-binding transcription factor activity
XACM_2783	COG2207	Transcriptional regulator
XACM_2787	COG1309	transcriptional regulator
XACM_2788	COG1538	Outer membrane efflux protein
XACM_2789	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XACM_2792	COG0735	belongs to the Fur family
XACM_2793	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XACM_2798	COG4452	Inner membrane protein CreD
XACM_2800	COG2205	protein histidine kinase activity
XACM_2801	COG0745	RESPONSE REGULATOR receiver
XACM_2802	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XACM_2804	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XACM_2806	COG2198	Histidine kinase
XACM_2806	COG0643	Histidine kinase
XACM_2807	COG0840	transmembrane signaling receptor activity
XACM_2808	COG0835	chemotaxis
XACM_2809	COG2200	EAL domain
XACM_2809	COG2199	diguanylate cyclase activity
XACM_2809	COG2202	Pas domain
XACM_2810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XACM_2811	COG2201	protein-glutamate methylesterase activity
XACM_2812	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XACM_2813	COG3590	peptidase
XACM_2815	COG0588	phosphoglycerate mutase activity
XACM_2816	COG1515	deoxyribonuclease V activity
XACM_2818	COG1741	Belongs to the pirin family
XACM_2821	COG1741	Belongs to the pirin family
XACM_2822	COG1966	Carbon starvation protein
XACM_2823	COG2879	small protein
XACM_2831	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
XACM_2832	COG1529	Aldehyde oxidase and xanthine dehydrogenase
XACM_2833	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
XACM_2834	COG2080	2 iron, 2 sulfur cluster binding
XACM_2835	COG3321	synthase
XACM_2835	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_2835	COG0604	alcohol dehydrogenase
XACM_2836	COG4251	negative regulation of phosphorylation
XACM_2836	COG3706	GGDEF domain
XACM_2836	COG2203	Gaf domain
XACM_2836	COG5001	Diguanylate cyclase
XACM_2837	COG0629	single-stranded DNA binding
XACM_2838	COG0142	geranyltranstransferase activity
XACM_2840	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XACM_2843	COG0527	aspartate kinase activity
XACM_2844	COG0384	phenazine biosynthesis protein PhzF
XACM_2845	COG0384	phenazine biosynthesis protein PhzF
XACM_2847	COG1764	response to oxidative stress
XACM_2848	COG0540	Belongs to the ATCase OTCase family
XACM_2849	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XACM_2850	COG1678	Uncharacterized ACR, COG1678
XACM_2851	COG0519	Catalyzes the synthesis of GMP from XMP
XACM_2856	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XACM_2859	COG0739	heme binding
XACM_2863	COG0693	protein deglycase activity
XACM_2865	COG1959	2 iron, 2 sulfur cluster binding
XACM_2866	COG0719	Fe-S assembly protein
XACM_2867	COG0396	ATPase activity
XACM_2868	COG0719	Fe-S assembly protein
XACM_2869	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XACM_2870	COG0456	acetyltransferase
XACM_2872	COG4774	siderophore transport
XACM_2873	COG3128	pkhd-type hydroxylase
XACM_2878	COG1477	protein flavinylation
XACM_2879	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XACM_2882	COG1555	photosystem II stabilization
XACM_2887	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XACM_2889	COG0628	permease
XACM_2891	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XACM_2893	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XACM_2897	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XACM_2898	COG0271	Belongs to the BolA IbaG family
XACM_2900	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XACM_2902	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XACM_2903	COG1137	ATPase activity
XACM_2906	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XACM_2907	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
XACM_2908	COG1660	Displays ATPase and GTPase activities
XACM_2910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XACM_2911	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XACM_2912	COG2239	Acts as a magnesium transporter
XACM_2914	COG1294	oxidase, subunit
XACM_2915	COG1271	oxidase subunit
XACM_2917	COG1113	amino acid transport
XACM_2922	COG2197	response regulator
XACM_2923	COG0531	amino acid
XACM_2935	COG2814	Major facilitator Superfamily
XACM_2937	COG0754	glutathionylspermidine amidase activity
XACM_2942	COG1842	Phage shock protein A
XACM_2944	COG0259	pyridoxamine-phosphate oxidase activity
XACM_2945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XACM_2946	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XACM_2948	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XACM_2949	COG2814	Major facilitator Superfamily
XACM_2954	COG2353	YceI-like domain
XACM_2958	COG1760	l-serine dehydratase
XACM_2960	COG0460	homoserine dehydrogenase
XACM_2960	COG0527	aspartate kinase activity
XACM_2961	COG0626	cystathionine gamma-synthase activity
XACM_2962	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XACM_2963	COG0739	heme binding
XACM_2964	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XACM_2965	COG1272	protein, Hemolysin III
XACM_2966	COG2982	Protein involved in outer membrane biogenesis
XACM_2967	COG0517	IMP dehydrogenase activity
XACM_2967	COG0516	GMP reductase activity
XACM_2968	COG0463	Glycosyl transferase, family 2
XACM_2969	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XACM_2970	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XACM_2973	COG1309	transcriptional regulator
XACM_2974	COG2267	carboxylic ester hydrolase activity
XACM_2975	COG1960	acyl-CoA dehydrogenase activity
XACM_2980	COG0509	glycine decarboxylation via glycine cleavage system
XACM_2981	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XACM_2983	COG0330	HflC and HflK could
XACM_2984	COG1742	UPF0060 membrane protein
XACM_2985	COG3956	TIGRFAM MazG family protein
XACM_2987	COG0494	nUDIX hydrolase
XACM_2989	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XACM_2990	COG0837	glucose binding
XACM_2994	COG3858	chitin binding
XACM_2994	COG1388	LysM domain
XACM_2995	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XACM_2997	COG1472	Belongs to the glycosyl hydrolase 3 family
XACM_2999	COG3537	Alpha-1,2-mannosidase
XACM_3008	COG3142	Participates in the control of copper homeostasis
XACM_3009	COG1446	asparaginase
XACM_3011	COG2304	oxidoreductase activity
XACM_3012	COG1595	DNA-templated transcription, initiation
XACM_3018	COG0840	transmembrane signaling receptor activity
XACM_3019	COG0835	chemotaxis
XACM_3022	COG0189	ligase activity
XACM_3025	COG1397	ADP-ribosylglycohydrolase
XACM_3026	COG1214	PFAM Peptidase M22, glycoprotease
XACM_3027	COG1199	ATP-dependent helicase activity
XACM_3029	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XACM_3030	COG1215	transferase activity, transferring glycosyl groups
XACM_3032	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XACM_3033	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
XACM_3034	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
XACM_3035	COG0535	radical SAM domain protein
XACM_3036	COG0535	radical SAM domain protein
XACM_3040	COG0837	glucose binding
XACM_3042	COG1643	Atp-dependent helicase
XACM_3043	COG0783	Belongs to the Dps family
XACM_3044	COG0514	ATP-dependent DNA helicase (RecQ)
XACM_3049	COG1187	pseudouridine synthase activity
XACM_3051	COG0840	transmembrane signaling receptor activity
XACM_3055	COG3920	Histidine kinase
XACM_3058	COG0602	queuosine metabolic process
XACM_3060	COG2885	chlorophyll binding
XACM_3061	COG0823	Involved in the tonB-independent uptake of proteins
XACM_3063	COG0848	biopolymer transport protein
XACM_3065	COG0824	Thioesterase
XACM_3066	COG2255	four-way junction helicase activity
XACM_3068	COG3158	transport of potassium into the cell
XACM_3069	COG0632	four-way junction helicase activity
XACM_3070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XACM_3071	COG0217	transcriptional regulatory protein
XACM_3074	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XACM_3077	COG0477	Major facilitator Superfamily
XACM_3080	COG0657	acetylesterase activity
XACM_3080	COG2755	lipolytic protein G-D-S-L family
XACM_3084	COG0488	(ABC) transporter
XACM_3090	COG4651	solute:proton antiporter activity
XACM_3090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XACM_3092	COG4772	TonB-dependent receptor
XACM_3094	COG4264	IucA IucC family
XACM_3095	COG2814	Major facilitator Superfamily
XACM_3097	COG0019	diaminopimelate decarboxylase activity
XACM_3101	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XACM_3103	COG1492	cobalamin metabolic process
XACM_3104	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XACM_3108	COG4206	TonB-dependent receptor
XACM_3109	COG0542	response to heat
XACM_3110	COG1116	anion transmembrane transporter activity
XACM_3119	COG1877	trehalose-phosphatase activity
XACM_3120	COG3387	PFAM Glycoside hydrolase 15-related
XACM_3123	COG0840	transmembrane signaling receptor activity
XACM_3124	COG3011	Protein conserved in bacteria
XACM_3127	COG0564	pseudouridine synthase activity
XACM_3128	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XACM_3130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XACM_3130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XACM_3133	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XACM_3134	COG0045	succinate-CoA ligase (ADP-forming) activity
XACM_3140	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XACM_3141	COG0237	dephospho-CoA kinase activity
XACM_3143	COG0745	RESPONSE REGULATOR receiver
XACM_3145	COG0189	ligase activity
XACM_3165	COG0210	DNA helicase
XACM_3174	COG2003	Belongs to the UPF0758 family
XACM_3186	COG2963	transposase activity
XACM_3187	COG2801	Transposase and inactivated derivatives
XACM_3196	COG2022	thiamine diphosphate biosynthetic process
XACM_3197	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XACM_3198	COG3273	potassium ion transport
XACM_3198	COG0471	metal ion transport
XACM_3202	COG1970	mechanosensitive ion channel activity
XACM_3204	COG1609	Transcriptional regulator
XACM_3206	COG3250	beta-galactosidase activity
XACM_3207	COG4948	Mandelate Racemase Muconate Lactonizing
XACM_3210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XACM_3213	COG0308	aminopeptidase N
XACM_3214	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XACM_3217	COG0529	Catalyzes the synthesis of activated sulfate
XACM_3217	COG2895	sulfate adenylyltransferase (ATP) activity
XACM_3218	COG0175	sulfate reduction
XACM_3219	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XACM_3220	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XACM_3221	COG0175	sulfate reduction
XACM_3229	COG1648	precorrin-2 dehydrogenase activity
XACM_3229	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XACM_3232	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
XACM_3233	COG3588	fructose-bisphosphate aldolase
XACM_3235	COG0469	pyruvate kinase activity
XACM_3237	COG0126	phosphoglycerate kinase activity
XACM_3241	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XACM_3244	COG3047	cAMP biosynthetic process
XACM_3245	COG3047	cAMP biosynthetic process
XACM_3247	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XACM_3247	COG3453	Protein conserved in bacteria
XACM_3248	COG0725	ABC transporter, periplasmic molybdate-binding protein
XACM_3249	COG4149	molybdate abc transporter
XACM_3250	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XACM_3257	COG1376	ErfK ybiS ycfS ynhG family protein
XACM_3258	COG0739	heme binding
XACM_3259	COG4773	Receptor
XACM_3260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XACM_3261	COG1301	dicarboxylic acid transport
XACM_3264	COG2304	oxidoreductase activity
XACM_3268	COG0714	Associated with various cellular activities
XACM_3274	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XACM_3277	COG0254	rRNA binding
XACM_3278	COG1957	nucleoside hydrolase
XACM_3279	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XACM_3281	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XACM_3282	COG1758	RNA polymerase activity
XACM_3283	COG0194	GDP metabolic process
XACM_3284	COG1561	YicC-like family, N-terminal region
XACM_3285	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XACM_3287	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XACM_3288	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XACM_3291	COG0006	proline dipeptidase activity
XACM_3293	COG0006	proline dipeptidase activity
XACM_3294	COG3079	Belongs to the UPF0149 family
XACM_3297	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XACM_3299	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XACM_3301	COG2912	Transglutaminase-like superfamily
XACM_3302	COG1773	rubredoxin
XACM_3303	COG0352	thiamine-phosphate diphosphorylase activity
XACM_3307	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XACM_3309	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XACM_3310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XACM_3316	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XACM_3317	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XACM_3318	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_3320	COG0671	phosphoesterase, PA-phosphatase related
XACM_3322	COG3781	membrane
XACM_3325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XACM_3326	COG0563	adenylate kinase activity
XACM_3329	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
XACM_3332	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XACM_3337	COG3710	Transcriptional regulator
XACM_3338	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XACM_3340	COG0840	transmembrane signaling receptor activity
XACM_3343	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XACM_3347	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XACM_3348	COG0473	3-isopropylmalate dehydrogenase activity
XACM_3349	COG0066	3-isopropylmalate dehydratase activity
XACM_3350	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XACM_3354	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XACM_3355	COG1538	Outer membrane efflux protein
XACM_3356	COG1519	Transferase
XACM_3357	COG1560	Kdo2-lipid A biosynthetic process
XACM_3362	COG0280	phosphate acetyltransferase
XACM_3362	COG0281	malic enzyme
XACM_3363	COG1301	dicarboxylic acid transport
XACM_3368	COG0583	DNA-binding transcription factor activity
XACM_3369	COG0667	Aldo Keto reductase
XACM_3372	COG2197	response regulator
XACM_3373	COG1840	ABC-type Fe3 transport system, periplasmic component
XACM_3374	COG0642	Histidine kinase
XACM_3377	COG2851	Citrate transporter
XACM_3378	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_3379	COG1609	Transcriptional regulator
XACM_3380	COG2211	Major facilitator Superfamily
XACM_3385	COG1162	GTPase activity
XACM_3392	COG0436	Aminotransferase
XACM_3395	COG0726	polysaccharide deacetylase
XACM_3396	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XACM_3399	COG3964	amidohydrolase
XACM_3400	COG0402	S-adenosylhomocysteine deaminase activity
XACM_3404	COG1307	EDD domain protein, DegV family
XACM_3405	COG0242	peptide deformylase activity
XACM_3409	COG0457	Tetratricopeptide repeat
XACM_3410	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
XACM_3411	COG1215	transferase activity, transferring glycosyl groups
XACM_3412	COG1215	transferase activity, transferring glycosyl groups
XACM_3414	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XACM_3423	COG2188	Transcriptional regulator
XACM_3425	COG1450	Type ii and iii secretion system protein
XACM_3428	COG3166	PFAM Fimbrial assembly family protein
XACM_3429	COG3156	type II secretion system protein K
XACM_3430	COG4795	General secretion pathway protein
XACM_3431	COG2165	general secretion pathway protein
XACM_3432	COG4970	Tfp pilus assembly protein FimT
XACM_3433	COG2165	general secretion pathway protein
XACM_3434	COG1459	type II secretion system
XACM_3435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XACM_3437	COG1404	Belongs to the peptidase S8 family
XACM_3438	COG5295	Hep Hag repeat protein
XACM_3439	COG1404	Belongs to the peptidase S8 family
XACM_3440	COG5295	Hep Hag repeat protein
XACM_3441	COG0047	phosphoribosylformylglycinamidine synthase activity
XACM_3441	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XACM_3442	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XACM_3444	COG4974	Belongs to the 'phage' integrase family
XACM_3448	COG0795	lipopolysaccharide-transporting ATPase activity
XACM_3450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XACM_3453	COG0525	valine-tRNA ligase activity
XACM_3460	COG1183	phosphatidylcholine synthase activity
XACM_3462	COG0442	prolyl-tRNA aminoacylation
XACM_3465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XACM_3466	COG1127	ABC transporter
XACM_3467	COG3218	ABC-type transport auxiliary lipoprotein component
XACM_3467	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XACM_3473	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
XACM_3474	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XACM_3475	COG0662	Cupin 2, conserved barrel domain protein
XACM_3475	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XACM_3481	COG2086	electron transfer activity
XACM_3484	COG0546	phosphoglycolate phosphatase activity
XACM_3484	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XACM_3485	COG0277	FAD linked oxidase domain protein
XACM_3487	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XACM_3491	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XACM_3492	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
XACM_3496	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XACM_3502	COG0626	cystathionine gamma-synthase activity
XACM_3508	COG0625	glutathione transferase activity
XACM_3510	COG0513	Belongs to the DEAD box helicase family
XACM_3511	COG0720	synthase
XACM_3513	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XACM_3514	COG1956	GAF domain-containing protein
XACM_3517	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XACM_3518	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XACM_3521	COG0339	signal peptide processing
XACM_3531	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XACM_3532	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_3533	COG1136	(ABC) transporter
XACM_3534	COG0577	efflux transmembrane transporter activity
XACM_3535	COG1136	(ABC) transporter
XACM_3535	COG0577	efflux transmembrane transporter activity
XACM_3537	COG2204	response regulator
XACM_3539	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XACM_3542	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XACM_3543	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XACM_3544	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XACM_3545	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XACM_3546	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XACM_3547	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XACM_3549	COG0356	it plays a direct role in the translocation of protons across the membrane
XACM_3554	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XACM_3556	COG0508	dehydrogenase complex catalyzes the overall conversion of
XACM_3565	COG2011	ABC-type metal ion transport system permease component
XACM_3566	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XACM_3567	COG0697	spore germination
XACM_3568	COG1666	GTP binding
XACM_3570	COG0784	Response regulator, receiver
XACM_3570	COG2198	Histidine kinase
XACM_3570	COG5002	protein histidine kinase activity
XACM_3574	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XACM_3575	COG1187	pseudouridine synthase activity
XACM_3576	COG2813	Specifically methylates the guanine in position
XACM_3581	COG2205	protein histidine kinase activity
XACM_3581	COG2202	Pas domain
XACM_3585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XACM_3586	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XACM_3587	COG1522	sequence-specific DNA binding
XACM_3597	COG0842	Transport permease protein
XACM_3598	COG1131	(ABC) transporter
XACM_3599	COG0025	NhaP-type Na H and K H
XACM_3600	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
XACM_3601	COG1573	uracil-dna glycosylase
XACM_3603	COG3384	dioxygenase
XACM_3604	COG0583	DNA-binding transcription factor activity
XACM_3606	COG0667	Aldo Keto reductase
XACM_3609	COG3590	peptidase
XACM_3612	COG0531	amino acid
XACM_3615	COG2972	Histidine kinase
XACM_3618	COG3685	Protein conserved in bacteria
XACM_3619	COG3546	catalase activity
XACM_3625	COG2204	response regulator
XACM_3627	COG1271	oxidase subunit
XACM_3628	COG1294	oxidase, subunit
XACM_3631	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_3632	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XACM_3636	COG1132	(ABC) transporter
XACM_3639	COG1063	alcohol dehydrogenase
XACM_3654	COG0251	oxidation-reduction process
XACM_3657	COG0583	DNA-binding transcription factor activity
XACM_3658	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XACM_3664	COG0659	secondary active sulfate transmembrane transporter activity
XACM_3665	COG0038	chloride channel
XACM_3667	COG0024	Methionine aminopeptidase
XACM_3670	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_3673	COG2801	Transposase and inactivated derivatives
XACM_3674	COG2963	transposase activity
XACM_3688	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XACM_3689	COG1560	Kdo2-lipid A biosynthetic process
XACM_3690	COG1490	D-aminoacyl-tRNA deacylase activity
XACM_3699	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XACM_3699	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XACM_3700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XACM_3701	COG0242	peptide deformylase activity
XACM_3702	COG1652	LysM domain
XACM_3703	COG0758	DNA mediated transformation
XACM_3707	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XACM_3707	COG1754	DNA topoisomerase type I activity
XACM_3708	COG0009	L-threonylcarbamoyladenylate synthase
XACM_3711	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_3713	COG0616	signal peptide processing
XACM_3714	COG0534	Mate efflux family protein
XACM_3719	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XACM_3720	COG0625	glutathione transferase activity
XACM_3723	COG1252	NADH dehydrogenase
XACM_3724	COG2860	membrane
XACM_3725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XACM_3726	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XACM_3727	COG2201	protein-glutamate methylesterase activity
XACM_3728	COG2177	Part of the ABC transporter FtsEX involved in
XACM_3729	COG2884	Cell division ATP-binding protein ftsE
XACM_3731	COG3118	belongs to the thioredoxin family
XACM_3732	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XACM_3734	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XACM_3735	COG0583	DNA-binding transcription factor activity
XACM_3739	COG1652	LysM domain
XACM_3740	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XACM_3740	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XACM_3741	COG1473	amidohydrolase
XACM_3742	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_3743	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XACM_3745	COG5383	Protein conserved in bacteria
XACM_3753	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
XACM_3754	COG3023	N-Acetylmuramoyl-L-alanine amidase
XACM_3756	COG4948	Mandelate Racemase Muconate Lactonizing
XACM_3758	COG0531	amino acid
XACM_3761	COG4682	membrane
XACM_3762	COG2133	pyrroloquinoline quinone binding
XACM_3764	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XACM_3765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XACM_3766	COG0828	Belongs to the bacterial ribosomal protein bS21 family
XACM_3767	COG1610	YqeY-like protein
XACM_3769	COG1295	ribonuclease BN
XACM_3770	COG0358	DNA primase activity
XACM_3773	COG0109	protoheme IX farnesyltransferase activity
XACM_3779	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
XACM_3782	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XACM_3791	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XACM_3792	COG0739	heme binding
XACM_3793	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XACM_3795	COG2223	nitrite transmembrane transporter activity
XACM_3796	COG0708	Exodeoxyribonuclease III
XACM_3797	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XACM_3799	COG1192	Involved in chromosome partitioning
XACM_3800	COG1475	DNA binding
XACM_3803	COG0463	Glycosyl transferase, family 2
XACM_3807	COG0756	dUTP diphosphatase activity
XACM_3808	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XACM_3809	COG2003	Belongs to the UPF0758 family
XACM_3810	COG0018	arginyl-trna synthetase
XACM_3813	COG4221	oxidoreductase activity
XACM_3814	COG2755	lipolytic protein G-D-S-L family
XACM_3814	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XACM_3816	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XACM_3817	COG1166	arginine decarboxylase activity
XACM_3818	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XACM_3822	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XACM_3822	COG3291	Pkd domain containing protein
XACM_3825	COG0606	chelatase, subunit chli
XACM_3828	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XACM_3836	COG1690	Belongs to the RtcB family
XACM_3844	COG1090	epimerase
XACM_3845	COG0745	RESPONSE REGULATOR receiver
XACM_3846	COG0642	Histidine kinase
XACM_3850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XACM_3854	COG0628	permease
XACM_3855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XACM_3856	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XACM_3859	COG0753	catalase activity
XACM_3862	COG2197	response regulator
XACM_3863	COG4585	Histidine kinase
XACM_3864	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_3865	COG1136	(ABC) transporter
XACM_3870	COG0697	spore germination
XACM_3873	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XACM_3874	COG0180	Tryptophanyl-tRNA synthetase
XACM_3875	COG3237	CsbD-like
XACM_3883	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XACM_3886	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XACM_3887	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XACM_3887	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XACM_3892	COG2205	protein histidine kinase activity
XACM_3893	COG0745	RESPONSE REGULATOR receiver
XACM_3895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XACM_3901	COG1199	ATP-dependent helicase activity
XACM_3904	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XACM_3914	COG0625	glutathione transferase activity
XACM_3921	COG4555	ABC transporter
XACM_3923	COG1476	TRANSCRIPTIONal
XACM_3928	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XACM_3929	COG1131	(ABC) transporter
XACM_3930	COG0842	Transport permease protein
XACM_3931	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XACM_3937	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XACM_3938	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XACM_3940	COG0045	succinate-CoA ligase (ADP-forming) activity
XACM_3940	COG1042	CoA-binding domain protein
XACM_3940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XACM_3943	COG2239	Acts as a magnesium transporter
XACM_3950	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XACM_3951	COG3387	PFAM Glycoside hydrolase 15-related
XACM_3953	COG3100	YcgL domain-containing protein
XACM_3954	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XACM_3956	COG0463	Glycosyl transferase, family 2
XACM_3959	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_3966	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XACM_3969	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XACM_3976	COG0408	coproporphyrinogen oxidase activity
XACM_3984	COG0631	protein serine/threonine phosphatase activity
XACM_3989	COG0667	Aldo Keto reductase
XACM_3990	COG0583	DNA-binding transcription factor activity
XACM_3993	COG3501	Rhs element vgr protein
XACM_4020	COG0210	DNA helicase
XACM_4023	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XACM_4024	COG0583	DNA-binding transcription factor activity
XACM_4025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XACM_4027	COG2159	amidohydrolase
XACM_4028	COG0267	Belongs to the bacterial ribosomal protein bL33 family
XACM_4029	COG0227	Belongs to the bacterial ribosomal protein bL28 family
XACM_4033	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XACM_4038	COG0357	Ribosomal RNA small subunit methyltransferase G
XACM_4039	COG3540	Alkaline phosphatase
XACM_4041	COG2091	lysine biosynthetic process via aminoadipic acid
XACM_4044	COG0708	Exodeoxyribonuclease III
XACM_4046	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XACM_4047	COG3162	membrane
XACM_4049	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XACM_4054	COG3507	Belongs to the glycosyl hydrolase 43 family
XACM_4057	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_4058	COG0179	Fumarylacetoacetate (FAA) hydrolase
XACM_4060	COG4948	Mandelate Racemase Muconate Lactonizing
XACM_4061	COG3254	rhamnose metabolic process
XACM_4062	COG0738	Major facilitator superfamily
XACM_4063	COG1414	Transcriptional regulator
XACM_4064	COG1971	Probably functions as a manganese efflux pump
XACM_4065	COG2205	protein histidine kinase activity
XACM_4068	COG3459	Glycosyltransferase 36 associated
XACM_4069	COG2211	Major facilitator Superfamily
XACM_4070	COG3265	gluconokinase activity
XACM_4071	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XACM_4075	COG2911	Protein conserved in bacteria
XACM_4076	COG0729	surface antigen
XACM_4077	COG4771	TonB-dependent receptor
XACM_4078	COG2963	transposase activity
XACM_4079	COG2801	Transposase and inactivated derivatives
XACM_4081	COG0457	Tetratricopeptide repeat
XACM_4083	COG0752	glycyl-tRNA synthetase alpha subunit
XACM_4084	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XACM_4087	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XACM_4087	COG0519	Catalyzes the synthesis of GMP from XMP
XACM_4089	COG0805	protein transport
XACM_4090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XACM_4091	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XACM_4093	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XACM_4097	COG2974	May be involved in recombination
XACM_4098	COG0037	tRNA processing
XACM_4099	COG2115	Belongs to the xylose isomerase family
XACM_4101	COG3661	Belongs to the glycosyl hydrolase 67 family
XACM_4103	COG4948	Mandelate Racemase Muconate Lactonizing
XACM_4105	COG1472	Belongs to the glycosyl hydrolase 3 family
XACM_4106	COG0246	Mannitol dehydrogenase
XACM_4116	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XACM_4121	COG3386	PFAM SMP-30 Gluconolaconase
XACM_4123	COG3250	beta-galactosidase activity
XACM_4124	COG1904	glucuronate isomerase
XACM_4125	COG3693	PFAM glycoside hydrolase, family 10
XACM_4127	COG3693	PFAM glycoside hydrolase, family 10
XACM_4130	COG2211	Major facilitator Superfamily
XACM_4134	COG2963	transposase activity
XACM_4135	COG2801	Transposase and inactivated derivatives
XACM_4140	COG3321	synthase
XACM_4140	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_4140	COG0604	alcohol dehydrogenase
XACM_4141	COG2937	Belongs to the GPAT DAPAT family
XACM_4147	COG0284	orotidine-5'-phosphate decarboxylase activity
XACM_4148	COG3132	Protein of unknown function, DUF480
XACM_4149	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
XACM_4152	COG0210	DNA helicase
XACM_4153	COG1435	thymidine kinase activity
XACM_4155	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XACM_4157	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XACM_4164	COG3135	benzoate transporter
XACM_4168	COG0676	glucose-6-phosphate 1-epimerase activity
XACM_4170	COG3012	SEC-C Motif Domain Protein
XACM_4171	COG0730	response to heat
XACM_4175	COG0302	gtp cyclohydrolase
XACM_4178	COG1566	PFAM secretion protein HlyD family protein
XACM_4180	COG1289	transmembrane transporter activity
XACM_4181	COG0477	Major facilitator Superfamily
XACM_4183	COG0583	DNA-binding transcription factor activity
XACM_4184	COG4221	oxidoreductase activity
XACM_4186	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XACM_4194	COG2801	Transposase and inactivated derivatives
XACM_4195	COG2963	transposase activity
XACM_4200	COG0564	pseudouridine synthase activity
XACM_4208	COG1309	transcriptional regulator
XACM_4210	COG1028	Short-chain dehydrogenase reductase Sdr
XACM_4218	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XACM_4219	COG1074	ATP-dependent DNA helicase activity
XACM_4220	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XACM_4227	COG1127	ABC transporter
XACM_4228	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XACM_4229	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XACM_4232	COG2853	Lipoprotein
XACM_4234	COG0386	Belongs to the glutathione peroxidase family
XACM_4236	COG1322	Protein conserved in bacteria
XACM_4237	COG0604	alcohol dehydrogenase
XACM_4238	COG0583	DNA-binding transcription factor activity
XACM_4242	COG0531	amino acid
XACM_4243	COG3537	Alpha-1,2-mannosidase
XACM_4246	COG2199	diguanylate cyclase activity
XACM_4246	COG2203	Gaf domain
XACM_4247	COG3835	regulator
XACM_4248	COG1929	Belongs to the glycerate kinase type-1 family
XACM_4249	COG2271	Major facilitator Superfamily
XACM_4252	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XACM_4253	COG0861	Integral membrane protein TerC family
XACM_4255	COG0584	glycerophosphoryl diester phosphodiesterase
XACM_4258	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XACM_4260	COG0706	membrane insertase activity
XACM_4261	COG0594	ribonuclease P activity
XACM_4262	COG0230	Belongs to the bacterial ribosomal protein bL34 family